TMEM114 Gene
protein-coding GIFtS: 36
GCID: GC16M008620
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transmembrane protein 114
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Aliases
for TMEM114 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protein 1141 2 |
Export aliases for TMEM114 gene to outside databasesPrevious GC identifers: GC16U900672 GC16M008560 |
Summaries
for TMEM114 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TMEM114 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMEM114 gene promoter:
ER-alpha RFX1 RREB-1 GATA-1 E47 YY1 CREB Zic1 deltaCREB LyF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM114
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM114 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p13.2 Ensembl cytogenetic band: 16p13.2 HGNC cytogenetic band: 16p13.2TMEM114 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M008620: view genomic region
(about GC identifiers)
Start:
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8,619,502 bp from pter |
End:
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8,622,304 bp from pter |
Size:
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2,803 bases |
Orientation:
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minus strand |
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Proteins
for TMEM114 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TM114_HUMAN, B3SHH9 (See
protein sequence)Recommended Name: Transmembrane protein 114 Size: 223 amino acids; 24166 Da
Subcellular location: Cell membrane (By similarity); Multi-pass membrane protein (Potential)
Developmental stage: Detected in the eye at gestational days 53-54 and at gestational week 10Explore the universe of human proteins at neXtProt for TMEM114: NX_B3SHH9
TMEM114 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_001139808.1
ENSEMBL proteins: ENSP00000454261
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
TMEM114 for ontologies About GeneDecksing
TMEM114 Antibody Products:
Assay Products for TMEM114: |
Protein
Domains /
Families
for TMEM114 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: B3SHH9 UniProtKB/Swiss-Prot: TM114_HUMAN, B3SHH9Similarity: Belongs to the PMP-22/EMP/MP20 family |
Function
for TMEM114 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM114 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM114
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TMEM114 (NM_001146336) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM114 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TMEM114 |
|
Pathways & Interactions
for TMEM114 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM114
|
Drugs & Compounds
for TMEM114 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM114
Search CenterWatch for drugs/clinical trials and news about TMEM114 / TM114
|
Transcripts
for TMEM114 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMEM114 gene: NM_001146336.1 Unigene Cluster for TMEM114: Transmembrane protein 114 Hs.150849 [show with all ESTs]Unigene Representative Sequence: NM_0011463362 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000568335(uc010uyd.2) ENST00000444171
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM114 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM114
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TMEM114 (NM_001146336) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM114 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TMEM114 |
Additional cDNA sequence: BC127923.1 BC150510.1 BC150511.1 2 DOTS entries: DT.40131201 DT.204729 24/38 AceView cDNA sequences (see all 38): BE327198 AW135815 BM670302 BU735064 AI688577 CD675263 BU737713 AI793290 AI972430 BU737015 AI935029 BE222379 BV178429 BM696438 BM706249 BM670967 BE669781 BE326310 AI698090 BE221391 BE467208 BF223871 AI279080 BE669761
GeneLoc Exon Structure
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Expression
for TMEM114 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM114 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTTAGAAGA
About this image
Genevestigator expression for TMEM114
SOURCE GeneReport for Unigene cluster: Hs.150849
SABiosciences Custom PCR Arrays for TMEM114
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM114 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM114 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM114 |
Orthologs
for TMEM114 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TMEM114 gene from 4/10 species (see all 10) About this table
ENSEMBL Gene Tree for TMEM114 (if available)
TreeFam Gene Tree for TMEM114 (if available) |
Paralogs
for TMEM114 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TMEM114 gene
- TMEM2352
1 SIMAP similar gene for TMEM114 using alignment to 2 protein entries: TM114_HUMAN (see all proteins):TMEM235
TMEM114 for paralogs About GeneDecksing
|
Genomic Variants
for TMEM114 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TMEM114
1 CNV: 53603
Human Gene Mutation Database (HGMD): TMEM114
Locus Specific Mutation Databases (LSDB): TMEM114
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM114 |
|
Disorders
/ Diseases
for TMEM114 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TMEM114 for disorders About GeneDecksing
OMIM gene information: 611579
OMIM disorders: --
UniProtKB/Swiss-Prot: TM114_HUMAN, B3SHH9
Note=Chromosomal aberrations involving TMEM114 may be a cause of congenital and juvenile cataracts.Translocation t(16;22) (p13.3;q11.2)
3  diseases for TMEM114: About MalaCardscongenital cataracts cataract microphthalmia
1 disease from the University of Copenhagen DISEASES database for TMEM114:Microphthalmia Export disorders for TMEM114 gene to outside databases
|
Publications
for TMEM114 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM114 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM114) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of a familial t(16;22) balanced translocation associated with congenital cataract leads to identification of a novel gene, TMEM114, expressed in the lens and disrupted by the translocation. (PubMed id 17492639)1, 2, 3 Jamieson R.V.... Black G.C.M. (2007)
- The cataract-associated protein TMEM114, and TMEM235, are glycosylated transmembrane proteins that are distinct from claudin family members. (PubMed id 21689651)1, 2 Maher G.J.... Manson F.D. (2011)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Expressed sequence tag analysis of adult human lens for the NEIBank project: over 2000 non-redundant transcripts, novel genes and splice variants. (PubMed id 12107413)2 Wistow G.... Peterson K. (2002)
- The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)
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External Searches for TMEM114 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing TMEM114 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMEM114 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM114 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM114 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for TMEM114 gene:
Search GeneIP for patents involving TMEM114
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM114 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM114 | | Browse OriGene genome-wide validated SYBR primer pairs | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMEM114 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM114 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM114 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TMEM114 | | OriGene Custom Protein Services for TMEM114 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM114 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM114 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM114 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM114 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM114 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM114 |
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| | | | Search Tocris compounds for TMEM114 |
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 | | | TMEM114 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for TMEM114 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TMEM114 |
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