Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TMEM114 Gene

protein-coding   GIFtS: 41
GCID: GC16M008620

Transmembrane Protein 114

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Transmembrane Protein 1141 2

External Ids:    HGNC: 332271   Entrez Gene: 2839532   Ensembl: ENSG000002322587   OMIM: 6115795   UniProtKB: B3SHH93   

Export aliases for TMEM114 gene to outside databases

Previous GC identifers: GC16U900672 GC16M008560


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TMEM114 Gene:
This gene encodes a glycosylated transmembrane protein that plays a role in lens and eye development. Mutations in
this gene, including a t(16;22)(p13.3;q11.2) translocation, are associated with congenital and juvenile cataract
disorders. Alternative splicing of this gene results in multiple transcript variants. (provided by RefSeq, Feb
2014)

GeneCards Summary for TMEM114 Gene:
TMEM114 (transmembrane protein 114) is a protein-coding gene. Diseases associated with TMEM114 include microphthalmia with cataract 2, and microphthalmia. An important paralog of this gene is TMEM235.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000016.10  NC_018927.2  NT_010393.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMEM114 gene promoter:
         ER-alpha   RFX1   RREB-1   GATA-1   E47   YY1   CREB   Zic1   deltaCREB   LyF-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TMEM114

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM114


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.2   Ensembl cytogenetic band:  16p13.2   HGNC cytogenetic band: 16p13.2

TMEM114 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM114 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M008620:  view genomic region     (about GC identifiers)

Start:
8,619,502 bp from pter      End:
8,622,304 bp from pter
Size:
2,803 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TM114_HUMAN, B3SHH9 (See protein sequence)
Recommended Name: Transmembrane protein 114  
Size: 223 amino acids; 24166 Da
Developmental stage: Detected in the eye at gestational days 53-54 and at gestational week 10

Explore the universe of human proteins at neXtProt for TMEM114: NX_B3SHH9

Post-translational modifications: 

  • Glycosylation2 at Asn55, Asn89
  • REFSEQ proteins (4 alternative transcripts): 
    NP_001139808.1  NP_001277024.1  NP_001277026.1  NP_001277027.1  

    ENSEMBL proteins: 
     ENSP00000454261  

    TMEM114 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TMEM114
    GenScript Custom Purified and Recombinant Proteins Services for TMEM114
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TMEM114

    TMEM114 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TMEM114
    Novus Biologicals TMEM114 Antibody
    Abcam antibodies for TMEM114
    Cloud-Clone Corp. Antibodies for TMEM114
    Search ThermoFisher Antibodies for TMEM114
    Search LSBio for Antibodies for TMEM114

    TMEM114 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TMEM114
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TMEM114
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TMEM114
    Cloud-Clone Corp. CLIAs for TMEM114


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR004031 PMP22/EMP/MP20/Claudin

    Graphical View of Domain Structure for InterPro Entry B3SHH9

    ProtoNet protein and cluster: B3SHH9

    UniProtKB/Swiss-Prot: TM114_HUMAN, B3SHH9
    Similarity: Belongs to the PMP-22/EMP/MP20 family


    TMEM114 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMEM114
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TMEM114

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMEM114
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMEM114

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat TMEM114 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate TMEM114
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TMEM114
    Predesigned siRNA for gene silencing in human, mouse, rat TMEM114

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TMEM114

    Clone
    Products:
         
    OriGene clones in human, mouse for TMEM114 (see all 5)
    OriGene ORF clones in mouse, rat for TMEM114
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TMEM114 (NM_001146336)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM114
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TMEM114

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TMEM114
    Browse ESI BIO Cell Lines and PureStem Progenitors for TMEM114 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM114


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TM114_HUMAN, B3SHH9: Cell membrane (By similarity); Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular2
    plasma membrane2
    cytosol1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--
    GO:0016324apical plasma membrane ----
    GO:0016327apicolateral plasma membrane ----

    TMEM114 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM114
    Interactions:

        Search GeneGlobe Interaction Network for TMEM114

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMEM114 (TM114)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TMEM114 gene (4 alternative transcripts): 
    NM_001146336.1  NM_001290095.1  NM_001290097.1  NM_001290098.1  

    Unigene Cluster for TMEM114:

    Transmembrane protein 114
    Hs.150849  [show with all ESTs]
    Unigene Representative Sequence: NM_001146336
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000568335(uc010uyd.2) ENST00000444171
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TMEM114 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate TMEM114
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TMEM114
    Predesigned siRNA for gene silencing in human, mouse, rat TMEM114
    Clone
    Products:
         
    OriGene clones in human, mouse for TMEM114 (see all 5)
    OriGene ORF clones in mouse, rat for TMEM114
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TMEM114 (NM_001146336)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM114
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TMEM114
    Primer
    Products:
        
    Browse OriGene qPCR
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMEM114
      QuantiTect SYBR Green Assays in human, mouse, rat TMEM114
      QuantiFast Probe-based Assays in human, mouse, rat TMEM114

    Additional mRNA sequence: 

    BC127923.1 BC150510.1 BC150511.1 

    2 DOTS entries:

    DT.40131201  DT.204729 

    Selected AceView cDNA sequences (see all 38):

    AW135815 BM670302 BE327198 AI688577 BU737015 BE222379 AI793290 AI935029 
    AI972430 CD675263 BU737713 BU735064 BV178429 BM696438 BM706249 BM670967 
    AW419350 BM705042 BE669761 AW341029 AI698090 BE669781 AI279080 BX117050 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TMEM114 expression in normal human tissues (normalized intensities)      TMEM114 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTTAGAAGA
    TMEM114 Expression
    About this image


    TMEM114 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Testis (Reproductive System)
             Pre-Sertoli Cells Testis Cord
     
     Ovary (Reproductive System)
             Granulosa Cells Primary Follicle
    TMEM114 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    SOURCE GeneReport for Unigene cluster: Hs.150849
        Custom PCR Arrays for TMEM114
    Primer
    Products:
    Browse OriGene qPCR
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMEM114
    QuantiTect SYBR Green Assays in human, mouse, rat TMEM114
    QuantiFast Probe-based Assays in human, mouse, rat TMEM114
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM114

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for TMEM114 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cldn261 , 5 claudin 261, 5 81.98(n)1
    85.14(a)1
      16 (3.84 cM)5
    747201  NM_029070.21  NP_083346.11 
     84092765 
    chicken
    (Gallus gallus)
    Aves TMEM1141 transmembrane protein 114 67.3(n)
    66.51(a)
      771894  XM_001235109.3  XP_001235110.3 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM1146
    transmembrane protein 114
    36(a)
    1 ↔ 1
    GL343263.1(849663-855718)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tmem1141 transmembrane protein 114 62.5(n)
    67.71(a)
      100497281  XM_002939438.2  XP_002939484.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1001502081 transmembrane protein 114-like 59.89(n)
    58.29(a)
      100150208  XM_001922273.2  XP_001922308.2 


    ENSEMBL Gene Tree for TMEM114 (if available)
    TreeFam Gene Tree for TMEM114 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TMEM114 gene
    TMEM2352  
    1 SIMAP similar gene for TMEM114 using alignment to 2 protein entries:     TM114_HUMAN (see all proteins):
    TMEM235

    TMEM114 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TMEM114 (see all 479)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs346127701,2
    C--8566919(+) AGGAA-/GGAAGGAAGGAAGGAA/GG
    AAGGAAGGAAGGAAGGAAGGAA
    ATTGA
    2 -- int1 cds11NA 2
    rs1438689821,2
    --8586874(+) CGGATA/GGGGAG 1 -- int10--------
    rs727805361,2
    C--8586881(+) GGAGCC/GCATTC 1 -- int10--------
    rs1402243071,2
    --8586926(+) GATTTC/TTCTGG 1 -- int10--------
    rs354496951,2
    C,F--8586958(+) TTAGTC/TTTGAA 1 -- int19Minor allele frequency- T:0.06NA WA 430
    rs1499178811,2
    C--8587022(+) GACCTA/CACCTG 1 -- int10--------
    rs620188601,2
    C--8587034(+) CCCCGT/CAGAAA 1 -- int14Minor allele frequency- C:0.12NA CSA WA 241
    rs751707511,2
    F--8587042(+) AAAGCC/TCATGT 1 -- int13Minor allele frequency- T:0.08NA WA 240
    rs341349001,2
    C,F--8587043(+) AAGCCC/AATGTC 1 -- int111Minor allele frequency- A:0.12NA EA WA CSA 609
    rs1449423451,2
    C--8587048(+) CATGTA/CATGCC 1 -- int10--------

    HapMap Linkage Disequilibrium report for TMEM114 (8619502 - 8622304 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TMEM114:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv340n27CNV Gain19166990

    Human Gene Mutation Database (HGMD): TMEM114
    Locus Specific Mutation Databases (LSDB): TMEM114

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TMEM114
    DNA2.0 Custom Variant and Variant Library Synthesis for TMEM114

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 611579    OMIM disorders: --

    UniProtKB/Swiss-Prot: TM114_HUMAN, B3SHH9
  • Note=Chromosomal aberrations involving TMEM114 may be a cause of congenital and juvenile cataracts.
    Translocation t(16;22) (p13.3;q11.2)

  • 5 diseases for TMEM114:    About MalaCards
    microphthalmia with cataract 2    microphthalmia    cataract    multiple myeloma
    myeloma

    1 disease from the University of Copenhagen DISEASES database for TMEM114:
    Microphthalmia

    TMEM114 for disorders           About GeneDecksing


    Export disorders for TMEM114 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TMEM114 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TMEM114)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a familial t(16;22) balanced translocation associated with congenital cataract leads to identification of a novel gene, TMEM114, expressed in the lens and disrupted by the translocation. (PubMed id 17492639)1, 2, 3 Jamieson R.V.... Black G.C.M. (Hum. Mutat. 2007)
    2. The cataract-associated protein TMEM114, and TMEM235, are glycosylated transmembrane proteins that are distinct from claudin family members. (PubMed id 21689651)1, 2 Maher G.J.... Manson F.D. (FEBS Lett. 2011)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The CTRB1/2 locus affects diabetes susceptibility and treatment via the incretin pathway. (PubMed id 23674605)1 't Hart L.M....Diamant M. (Diabetes 2013)
    5. Interstitial deletion at chromosome 16p13.2 involving TMEM114 (transmembrane protein 114) in a boy and his father without cataract. (PubMed id 24357539)1 Gai D....Yu S. (Am. J. Med. Genet. A 2013)
    6. A missense mutation in CRYGD linked with autosomal dominant congenital cataract of aculeiform type. (PubMed id 22669729)1 Vanita V. and Singh D. (Mol. Cell. Biochem. 2012)
    7. Chromosomal rearrangements and novel genes in disorders of eye development, cataract and glaucoma. (PubMed id 18637741)1 Mihelec M....Jamieson R.V. (Twin Res Hum Genet 2008)
    8. Expressed sequence tag analysis of adult human lens for the NEIBank project: over 2000 non-redundant transcripts, novel genes and splice variants. (PubMed id 12107413)2 Wistow G.... Peterson K. (Mol. Vis. 2002)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (Science 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 283953 HGNC: 33227 AceView: LOC283953 Ensembl:ENSG00000232258 euGenes: HUgn283953
    ECgene: TMEM114 H-InvDB: TMEM114

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TMEM114 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TMEM114 gene:
    Search GeneIP for patents involving TMEM114

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TMEM114  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TMEM114  
     Browse OriGene qSTAR qPCR primer pairs   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TMEM114   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TMEM114   OriGene Custom Protein Services for TMEM114  

     
     
     Block miRNA regulation of human, mouse, rat TMEM114 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TMEM114
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM114 Predesigned siRNA for gene silencing in human, mouse, rat TMEM114
     QuantiFast Probe-based Assays in human, mouse, rat TMEM114 QuantiTect SYBR Green Assays in human, mouse, rat TMEM114
     Custom PCR Arrays for TMEM114 Search Chromatin IP Primers for TMEM114
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMEM114  Search GeneGlobe Interaction Network for TMEM114
     Regulatory tfbs in TMEM114 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TMEM114 GenScript cDNA clones with any tag delivered in your preferred vector for TMEM114
     GenScript Custom Assay Services for TMEM114 GenScript Custom overexpressing Cell Line Services for TMEM114
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TMEM114 (TM114)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TMEM114 antibodies
     Antibodies for TMEM114
     See all of Abcam's Antibodies, Kits and Proteins for TMEM114
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for TMEM114
     Antibodies for TMEM114
     ELISAs for TMEM114
     CLIAs for TMEM114



     Browse ESI BIO Cell Lines and PureStem Progenitors for TMEM114
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM114
     Browse SwitchGear 3'UTR luciferase reporter plasmids for TMEM114
     Browse SwitchGear Promoter luciferase reporter plasmids for TMEM114
     Search ThermoFisher Antibodies for TMEM114
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TMEM114
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMEM114
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TMEM114
     Search LSBio for Antibodies for TMEM114
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TMEM114 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4