Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMEM110-MUSTN1 Gene

Aliases for TMEM110-MUSTN1 Gene

  • TMEM110-MUSTN1 Readthrough 2 3 5

External Ids for TMEM110-MUSTN1 Gene

Previous GeneCards Identifiers for TMEM110-MUSTN1 Gene

  • GC03U901716
  • GC03M052868
  • GC03M052869
  • GC03M052876

Summaries for TMEM110-MUSTN1 Gene

Entrez Gene Summary for TMEM110-MUSTN1 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring TMEM110 (transmembrane protein 110) and MUSTN1 (musculoskeletal, embryonic nuclear protein 1) genes. The read-through transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Nov 2010]

GeneCards Summary for TMEM110-MUSTN1 Gene

TMEM110-MUSTN1 (TMEM110-MUSTN1 Readthrough) is a Protein Coding gene. An important paralog of this gene is TMEM110.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM110-MUSTN1 Gene

Genomics for TMEM110-MUSTN1 Gene

Regulatory Elements for TMEM110-MUSTN1 Gene

Enhancers for TMEM110-MUSTN1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMEM110-MUSTN1 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM110-MUSTN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM110-MUSTN1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM110-MUSTN1 Gene

Chromosome:
3
Start:
52,833,115 bp from pter
End:
52,897,581 bp from pter
Size:
64,467 bases
Orientation:
Minus strand

Genomic View for TMEM110-MUSTN1 Gene

Genes around TMEM110-MUSTN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM110-MUSTN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM110-MUSTN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM110-MUSTN1 Gene

Proteins for TMEM110-MUSTN1 Gene

  • Protein details for TMEM110-MUSTN1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A8MSY1
    Recommended name:
    Protein TMEM110-MUSTN1
    Protein Accession:
    A8MSY1

    Protein attributes for TMEM110-MUSTN1 Gene

    Size:
    372 amino acids
    Molecular mass:
    41634 Da
    Quaternary structure:
    No Data Available
  • Protein details for TMEM110-MUSTN1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H0Y8V1
    Recommended name:
    Protein TMEM110-MUSTN1
    Protein Accession:
    H0Y8V1

    Protein attributes for TMEM110-MUSTN1 Gene

    Size:
    148 amino acids
    Molecular mass:
    16632 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM110-MUSTN1 Gene

Proteomics data for TMEM110-MUSTN1 Gene at MOPED

Protein Expression for TMEM110-MUSTN1 Gene

Post-translational modifications for TMEM110-MUSTN1 Gene

No Post-translational modifications

Other Protein References for TMEM110-MUSTN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM110-MUSTN1 Gene

Domains & Families for TMEM110-MUSTN1 Gene

Protein Domains for TMEM110-MUSTN1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM110-MUSTN1: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TMEM110-MUSTN1 Gene

Function for TMEM110-MUSTN1 Gene

Phenotypes for TMEM110-MUSTN1 Gene

genes like me logo Genes that share phenotypes with TMEM110-MUSTN1: view

Animal Models for TMEM110-MUSTN1 Gene

MGI Knock Outs for TMEM110-MUSTN1:

Animal Model Products

CRISPR Products

miRNA for TMEM110-MUSTN1 Gene

miRTarBase miRNAs that target TMEM110-MUSTN1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM110-MUSTN1 Gene

Localization for TMEM110-MUSTN1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM110-MUSTN1 Gene COMPARTMENTS Subcellular localization image for TMEM110-MUSTN1 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TMEM110-MUSTN1 Gene

Pathways & Interactions for TMEM110-MUSTN1 Gene

SuperPathways for TMEM110-MUSTN1 Gene

No Data Available

Interacting Proteins for TMEM110-MUSTN1 Gene

Gene Ontology (GO) - Biological Process for TMEM110-MUSTN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035988 chondrocyte proliferation IEA --
genes like me logo Genes that share ontologies with TMEM110-MUSTN1: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM110-MUSTN1 Gene

Drugs & Compounds for TMEM110-MUSTN1 Gene

No Compound Related Data Available

Transcripts for TMEM110-MUSTN1 Gene

mRNA/cDNA for TMEM110-MUSTN1 Gene

(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM110-MUSTN1 Gene

No ASD Table

Relevant External Links for TMEM110-MUSTN1 Gene

GeneLoc Exon Structure for
TMEM110-MUSTN1
ECgene alternative splicing isoforms for
TMEM110-MUSTN1

Expression for TMEM110-MUSTN1 Gene

mRNA expression in normal human tissues for TMEM110-MUSTN1 Gene

mRNA expression in normal human tissues for TMEM110-MUSTN1 Gene

Protein differential expression in normal tissues from HIPED for TMEM110-MUSTN1 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from for TMEM110-MUSTN1 Gene



genes like me logo Genes that share expression patterns with TMEM110-MUSTN1: view

Protein tissue co-expression partners for TMEM110-MUSTN1 Gene

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM110-MUSTN1 Gene

Orthologs for TMEM110-MUSTN1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TMEM110-MUSTN1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM110 35
  • 93.65 (n)
  • 97.62 (a)
TMEM110 36
  • 98 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TMEM110 35
  • 90.31 (n)
  • 93.41 (a)
-- 36
  • 92 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Tmem110 35
  • 91.75 (n)
  • 97.56 (a)
Tmem110 16
Tmem110 36
  • 97 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia TMEM110 35
  • 99.32 (n)
  • 98.98 (a)
TMEM110 36
  • 99 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tmem110 35
  • 90.36 (n)
  • 97.91 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 88 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 86 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 80 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 86 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem110.2 35
  • 72.01 (n)
  • 77.35 (a)
zebrafish
(Danio rerio)
Actinopterygii tmem110 35
  • 71.77 (n)
  • 79.1 (a)
tmem110 36
  • 72 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008662 35
  • 53.41 (n)
  • 44.58 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToMany
Species with no ortholog for TMEM110-MUSTN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM110-MUSTN1 Gene

ENSEMBL:
Gene Tree for TMEM110-MUSTN1 (if available)
TreeFam:
Gene Tree for TMEM110-MUSTN1 (if available)

Paralogs for TMEM110-MUSTN1 Gene

Paralogs for TMEM110-MUSTN1 Gene

(2) SIMAP similar genes for TMEM110-MUSTN1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TMEM110-MUSTN1: view

Variants for TMEM110-MUSTN1 Gene

Sequence variations from dbSNP and Humsavar for TMEM110-MUSTN1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs11626 -- 52,839,968(-) TGACA(A/G)TGTTA intron-variant
rs2276825 -- 52,852,589(+) TCAAA(C/T)AGGGA intron-variant
rs4302374 -- 52,871,786(+) AGATC(C/T)GTGCA intron-variant
rs2336150 -- 52,837,993(+) GTGTG(C/T)ACGTG intron-variant
rs2336151 -- 52,837,994(+) TGTGC(A/G)CGTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM110-MUSTN1 Gene

Variant ID Type Subtype PubMed ID
nsv834698 CNV Gain 17160897
nsv508928 CNV Insertion 20534489
nsv876797 CNV Loss 21882294

Variation tolerance for TMEM110-MUSTN1 Gene

Residual Variation Intolerance Score: 51.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.30; 25.90% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TMEM110-MUSTN1 Gene

Disorders for TMEM110-MUSTN1 Gene

Relevant External Links for TMEM110-MUSTN1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM110-MUSTN1

No disorders were found for TMEM110-MUSTN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM110-MUSTN1 Gene

Publications for TMEM110-MUSTN1 Gene

  1. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3 67
  2. Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. (PMID: 22610502) Kennedy R.B. … Poland G.A. (Hum. Genet. 2012) 3
  3. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TMEM110-MUSTN1 Gene

Sources for TMEM110-MUSTN1 Gene

Content