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Aliases for TMEM110 Gene

Aliases for TMEM110 Gene

  • Transmembrane Protein 110 2 3 4 5
  • STIM-Activating Enhancer Encoded By TMEM110 3 4
  • STIMATE 3 4
  • Store-Operated Calcium Entry Regulator STIMATE 3

External Ids for TMEM110 Gene

Previous GeneCards Identifiers for TMEM110 Gene

  • GC03M052843
  • GC03M052823
  • GC03M052849
  • GC03M052870

Summaries for TMEM110 Gene

GeneCards Summary for TMEM110 Gene

TMEM110 (Transmembrane Protein 110) is a Protein Coding gene. Diseases associated with TMEM110 include Ascaridiasis. An important paralog of this gene is TMEM110-MUSTN1.

UniProtKB/Swiss-Prot for TMEM110 Gene

  • Acts as a regulator of store-operated Ca(2+) entry (SOCE) at junctional sites that connect the endoplasmic reticulum (ER) and plasma membrane (PM), called ER-plasma membrane (ER-PM) junction or cortical ER (PubMed:26322679, PubMed:26644574). SOCE is a Ca(2+) influx following depletion of intracellular Ca(2+) stores (PubMed:26322679). Acts by interacting with STIM1, promoting STIM1 conformational switch (PubMed:26322679). Involved in STIM1 relocalization to ER-PM junctions (PubMed:26644574). Contributes to the maintenance and reorganization of store-dependent ER-PM junctions (PubMed:26644574).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM110 Gene

Genomics for TMEM110 Gene

Regulatory Elements for TMEM110 Gene

Enhancers for TMEM110 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G053071 1.5 FANTOM5 Ensembl ENCODE 12.2 -175.4 -175405 2.3 PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ETS1 ZNF143 ZNF207 RFT1 ITIH4 TMEM110 ITIH1 TMEM110-MUSTN1 ENSG00000243696 MUSTN1 SFMBT1 DCP1A GC03M053066
GH03G053102 1.3 FANTOM5 Ensembl ENCODE 12.6 -205.3 -205264 0.6 PKNOX1 KLF1 BACH1 EBF1 ZIC2 FOSL1 ZNF316 POLR2A NFE2 RELB PRKCD TMEM110 RFT1 ENSG00000243696 TMEM110-MUSTN1 MUSTN1 DCP1A PBRM1 ENSG00000272305
GH03G053140 1.7 FANTOM5 Ensembl ENCODE dbSUPER 8.1 -243.5 -243506 1.4 HDGF ZSCAN4 ZNF133 ZNF143 ZNF207 EGR2 ZNF263 USF2 ZNF398 ZNF148 RFT1 PRKCD ACTR8 NEK4 TMEM110 ITIH4 DCP1A ITIH3 PBRM1 TKT
GH03G052774 1.2 Ensembl ENCODE 10.1 +121.9 121895 2.2 FOXA2 ATF1 MLX ARID4B YBX1 ZNF48 YY1 ZNF143 PAF1 PPARG PBRM1 ITIH4-AS1 ITIH4 ENSG00000243696 MUSTN1 TMEM110 TMEM110-MUSTN1 ITIH3 ITIH1 NEK4
GH03G053144 1.3 Ensembl ENCODE dbSUPER 9.2 -248.8 -248780 3.3 HDGF PKNOX1 ARNT ZSCAN4 RAD21 ETV6 RELB CREM IKZF2 CBFB ENSG00000207109 TMEM110 TMEM110-MUSTN1 ENSG00000243696 MUSTN1 PRKCD PIR59540
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM110 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM110 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000152611 81 1400 HDGF HDAC1 ATF1 RB1 FUS SIN3A GLIS2 EGR1 ZNF366 SCRT2
ENSR00000304078 1081 201 ZNF366 SCRT2 IKZF1 ZNF600

Genomic Location for TMEM110 Gene

Chromosome:
3
Start:
52,836,219 bp from pter
End:
52,897,596 bp from pter
Size:
61,378 bases
Orientation:
Minus strand

Genomic View for TMEM110 Gene

Genes around TMEM110 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM110 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM110 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM110 Gene

Proteins for TMEM110 Gene

  • Protein details for TMEM110 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86TL2-STIMA_HUMAN
    Recommended name:
    Store-operated calcium entry regulator STIMATE
    Protein Accession:
    Q86TL2

    Protein attributes for TMEM110 Gene

    Size:
    294 amino acids
    Molecular mass:
    33187 Da
    Quaternary structure:
    • Homooligomer (PubMed:26322679). Interacts with STIM1 (PubMed:26322679).

neXtProt entry for TMEM110 Gene

Post-translational modifications for TMEM110 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM110 Gene

No data available for DME Specific Peptides for TMEM110 Gene

Domains & Families for TMEM110 Gene

Protein Domains for TMEM110 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM110 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86TL2

UniProtKB/Swiss-Prot:

STIMA_HUMAN :
  • The GXXXG motif may mediate oligomerization (PubMed:26322679). The C-terminus is necessary for its localization at ER-plasma membrane (ER-PM) junctions as well as for the store-dependent rearrangement of ER-PM junctions (PubMed:26644574).
  • Belongs to the STIMATE family.
Domain:
  • The GXXXG motif may mediate oligomerization (PubMed:26322679). The C-terminus is necessary for its localization at ER-plasma membrane (ER-PM) junctions as well as for the store-dependent rearrangement of ER-PM junctions (PubMed:26644574).
Family:
  • Belongs to the STIMATE family.
genes like me logo Genes that share domains with TMEM110: view

No data available for Gene Families for TMEM110 Gene

Function for TMEM110 Gene

Molecular function for TMEM110 Gene

UniProtKB/Swiss-Prot Function:
Acts as a regulator of store-operated Ca(2+) entry (SOCE) at junctional sites that connect the endoplasmic reticulum (ER) and plasma membrane (PM), called ER-plasma membrane (ER-PM) junction or cortical ER (PubMed:26322679, PubMed:26644574). SOCE is a Ca(2+) influx following depletion of intracellular Ca(2+) stores (PubMed:26322679). Acts by interacting with STIM1, promoting STIM1 conformational switch (PubMed:26322679). Involved in STIM1 relocalization to ER-PM junctions (PubMed:26644574). Contributes to the maintenance and reorganization of store-dependent ER-PM junctions (PubMed:26644574).

Gene Ontology (GO) - Molecular Function for TMEM110 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005246 calcium channel regulator activity IDA 26322679
GO:0005515 protein binding IPI 26322679
genes like me logo Genes that share ontologies with TMEM110: view

Phenotypes for TMEM110 Gene

genes like me logo Genes that share phenotypes with TMEM110: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM110 Gene

Localization for TMEM110 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM110 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Colocalizes with STIM1 at ER-plasma membrane (ER-PM) junctions, also called cortical endoplasmic reticulum (ER), in store-depleted calcium cells (PubMed:26644574). May translocate to ER-PM junctions in a STIM1-dependent manner in store-depleted cells (Probable). {ECO:0000269 PubMed:26644574, ECO:0000305 PubMed:26322679}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM110 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TMEM110 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA,IDA 26322679
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM110: view

Pathways & Interactions for TMEM110 Gene

SuperPathways for TMEM110 Gene

No Data Available

Interacting Proteins for TMEM110 Gene

Selected Interacting proteins: Q86TL2-STIMA_HUMAN for TMEM110 Gene via IID

Symbol External ID(s) Details
CIAO1
HSPH1

Gene Ontology (GO) - Biological Process for TMEM110 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0032237 activation of store-operated calcium channel activity IDA 26322679
GO:0035584 calcium-mediated signaling using intracellular calcium source IDA 26644574
GO:0051533 positive regulation of NFAT protein import into nucleus IDA 26644574
genes like me logo Genes that share ontologies with TMEM110: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM110 Gene

Drugs & Compounds for TMEM110 Gene

No Compound Related Data Available

Transcripts for TMEM110 Gene

Unigene Clusters for TMEM110 Gene

Transmembrane protein 110:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM110 Gene

No ASD Table

Relevant External Links for TMEM110 Gene

GeneLoc Exon Structure for
TMEM110
ECgene alternative splicing isoforms for
TMEM110

Expression for TMEM110 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM110 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM110 Gene

This gene is overexpressed in Whole Blood (x5.2).

NURSA nuclear receptor signaling pathways regulating expression of TMEM110 Gene:

TMEM110

SOURCE GeneReport for Unigene cluster for TMEM110 Gene:

Hs.744189

mRNA Expression by UniProt/SwissProt for TMEM110 Gene:

Q86TL2-STIMA_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for TMEM110 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with TMEM110: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM110 Gene

Orthologs for TMEM110 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TMEM110 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM110 35
  • 98 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Tmem110 35
  • 98 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 92 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 86 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia TMEM110 35
  • 78 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 71 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 81 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 87 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.2630 34
zebrafish
(Danio rerio)
Actinopterygii tmem110 35
  • 72 (a)
OneToMany
zgc63630 34
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL091C 34
  • 45.79 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPL162C 34
  • 44.85 (n)
-- 35
  • 26 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C10076g 34
  • 44.08 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU02834 34
  • 47.41 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 41 (a)
OneToMany
Species where no ortholog for TMEM110 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM110 Gene

ENSEMBL:
Gene Tree for TMEM110 (if available)
TreeFam:
Gene Tree for TMEM110 (if available)

Paralogs for TMEM110 Gene

Paralogs for TMEM110 Gene

(1) SIMAP similar genes for TMEM110 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TMEM110: view

Variants for TMEM110 Gene

Structural Variations from Database of Genomic Variants (DGV) for TMEM110 Gene

Variant ID Type Subtype PubMed ID
esv2762328 CNV loss 21179565
esv3596163 CNV gain 21293372
nsv508928 CNV insertion 20534489
nsv834698 CNV gain 17160897

Variation tolerance for TMEM110 Gene

Residual Variation Intolerance Score: 30.5% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM110 Gene

Human Gene Mutation Database (HGMD)
TMEM110
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM110

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for TMEM110 Gene

Disorders for TMEM110 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMEM110 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ascaridiasis
  • ascariasis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TMEM110

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM110
genes like me logo Genes that share disorders with TMEM110: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM110 Gene

Publications for TMEM110 Gene

  1. Proteomic mapping of ER-PM junctions identifies STIMATE as a regulator of Ca(2+) influx. (PMID: 26322679) Jing J. … Zhou Y. (Nat. Cell Biol. 2015) 3 4 64
  2. TMEM110 regulates the maintenance and remodeling of mammalian ER-plasma membrane junctions competent for STIM-ORAI signaling. (PMID: 26644574) Quintana A. … Hogan P.G. (Proc. Natl. Acad. Sci. U.S.A. 2015) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  5. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3 64

Products for TMEM110 Gene

Sources for TMEM110 Gene

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