TMEM110 Gene
protein-coding GIFtS: 38
GCID: GC03M052870
|
|
transmembrane protein 110
| |
Aliases
for TMEM110 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protein 1101 2 | | MGC520221 |
Export aliases for TMEM110 gene to outside databasesPrevious GC identifers: GC03M052843 GC03M052823 GC03M052849 |
Summaries
for TMEM110 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TMEM110 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMEM110 gene promoter:
E2F-4 E2F-3a E2F-5 E2F-2 NF-AT NF-AT4 NF-AT2 E2F E2F-1 NF-AT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM110
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM110 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p21.1 Ensembl cytogenetic band: 3p21.1 HGNC cytogenetic band: 3p21.1TMEM110 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M052870: view genomic region
(about GC identifiers)
Start:
|
52,870,235 bp from pter |
End:
|
52,931,612 bp from pter |
Size:
|
61,378 bases |
Orientation:
|
minus strand |
|
Proteins
for TMEM110 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TM110_HUMAN, Q86TL2 (See
protein sequence)Recommended Name: Transmembrane protein 110 Size: 294 amino acids; 33187 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)Explore the universe of human proteins at neXtProt for TMEM110: NX_Q86TL2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86TL2
TMEM110 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_940965.1
ENSEMBL proteins: ENSP00000418967 ENSP00000347195 ENSP00000418652 ENSP00000420219
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- | | GO:0016021 | integral to membrane |
IEA | -- |
TMEM110 for ontologies About GeneDecksing
TMEM110 Antibody Products:
Assay Products for TMEM110: |
Protein
Domains /
Families
for TMEM110 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMEM110 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q86TL2ProtoNet protein and cluster: Q86TL2 |
Function
for TMEM110 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM110 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM110
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TMEM110 (NM_198563) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM110 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM110 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM110 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
TMEM110 for ontologies About GeneDecksing
|
Pathways & Interactions
for TMEM110 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM110
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
TMEM110 for ontologies About GeneDecksing
|
Drugs & Compounds
for TMEM110 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM110
Search CenterWatch for drugs/clinical trials and news about TMEM110 / TM110
|
Transcripts
for TMEM110 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMEM110 gene: NM_198563.2 Unigene Cluster for TMEM110: Transmembrane protein 110 Hs.744189 [show with all ESTs]Unigene Representative Sequence: NM_1985636 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000482155 ENST00000355083(uc003dgd.3) ENST00000477591 ENST00000464769
ENST00000485356 ENST00000467979
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM110 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM110
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TMEM110 (NM_198563) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM110 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM110 |
Additional cDNA sequence: AK094932.1 AK124386.1 AY726591.1 BC022209.1 BC047015.1 BX648562.1 11 DOTS entries: DT.442833 DT.100730310 DT.97791092 DT.120911839 DT.120911912 DT.91653446 DT.95267426 DT.95267427 DT.99990794 DT.92004974 DT.95191247 24/428 AceView cDNA sequences (see all 428): AL557947 CB163884 AA723367 CB155974 NM_002218 BE909286 AI962765 BF969985 CR614295 F27979 CD614258 AV653979 AV654981 CB161586 BM802543 BI966873 CR591457 CB154334 CR603484 AA346122 AV648742 AV647796 CR625639 AV647813
GeneLoc Exon Structure
|
Expression
for TMEM110 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM110 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAACGTTTT
About this image
See TMEM110 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM110
SOURCE GeneReport for Unigene cluster: Hs.744189
SABiosciences Custom PCR Arrays for TMEM110
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM110
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM110 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM110 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM110 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM110 |
Orthologs
for TMEM110 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals and fungi.
Orthologs for TMEM110 gene from 7/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Tmem1101 , 5 |
transmembrane protein 1101, 5 |
91.78(n)1
97.57(a)1 |
|
14 (19.09 cM)5
691791 NM_028839.41 NP_083115.31
308255905 |
chicken
(Gallus gallus) |
Aves |
TMEM1106 |
Uncharacterized protein |
81(a) |
1 → many |
12(816166-843537) |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
87(a) |
1 → many |
2(155065097-155091122) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.26302 |
Xenopus laevis transcribed sequence with weak similarity more |
76.14(n) |
|
CA986488.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc636302 |
hypothetical protein MGC63630 |
74.34(n) |
|
393439 BC055172.1 |
mosquito
(Anopheles gambiae) |
Insecta |
AgaP_AGAP0086621 |
AGAP008662-PA |
53.28(n)
44.58(a) |
|
1275511 XM_001237592.2 XP_001237593.2 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
YPL162C1 |
hypothetical protein |
45.08(n)
32.12(a) |
|
855941 NP_015163.1 |
ENSEMBL Gene Tree for TMEM110 (if available)
TreeFam Gene Tree for TMEM110 (if available) |
Paralogs
for TMEM110 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TMEM110 gene
- TMEM110-MUSTN12
1 SIMAP similar gene for TMEM110 using alignment to 4 protein entries: TM110_HUMAN (see all proteins):TMEM110-MUSTN1
TMEM110 for paralogs About GeneDecksing
|
Genomic Variants
for TMEM110 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM110 (52870235 - 52931612 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TMEM110
1 CNV: 4339 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM110 |
|
Disorders
/ Diseases
for TMEM110 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for TMEM110 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM110 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM110) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. (PubMed id 22610502)1 Kennedy R.B....Poland G.A. (2012)
- Large-scale genome-wide association analysis of bipol ar disorder identifies a new susceptibility locus near ODZ4. (PubMed id 21926972)1 Sklar P....Purcell S.M. (2011)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
|
External Searches for TMEM110 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMEM110 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMEM110 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM110 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM110 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMEM110 gene:
Search GeneIP for patents involving TMEM110
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM110 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM110 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM110 | | | OriGene Protein Over-expression Lysate for TMEM110 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMEM110 | | OriGene 3'-UTR Clone for TMEM110 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM110 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM110 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TMEM110 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TMEM110 | | OriGene Custom Protein Services for TMEM110 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM110 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM110 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM110 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM110 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM110 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM110 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for TMEM110 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | TMEM110 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM110 |
|  |  |  | | | | Search ThermoFisher Antibodies for TMEM110 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM110 |
|
|
|
|
