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Aliases for TMEM11 Gene

Aliases for TMEM11 Gene

  • Transmembrane Protein 11 2 3
  • C17orf35 3 4
  • PM1 3 4
  • Transmembrane Protein 11, Mitochondrial 3
  • Chromosome 17 Open Reading Frame 35 2
  • Putative Receptor Protein 3
  • Protein PM1 4
  • Protein PMI 4
  • TMEM114 6
  • PMI 3

External Ids for TMEM11 Gene

Previous HGNC Symbols for TMEM11 Gene

  • C17orf35

Previous GeneCards Identifiers for TMEM11 Gene

  • GC17M021042
  • GC17M020303

Summaries for TMEM11 Gene

GeneCards Summary for TMEM11 Gene

TMEM11 (Transmembrane Protein 11) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM11 Gene

  • Plays a role in mitochondrial morphogenesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM11 Gene

Genomics for TMEM11 Gene

Regulatory Elements for TMEM11 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMEM11 Gene

Start:
21,197,280 bp from pter
End:
21,214,624 bp from pter
Size:
17,345 bases
Orientation:
Minus strand

Genomic View for TMEM11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM11 Gene

Proteins for TMEM11 Gene

  • Protein details for TMEM11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17152-TMM11_HUMAN
    Recommended name:
    Transmembrane protein 11, mitochondrial
    Protein Accession:
    P17152
    Secondary Accessions:
    • Q53YB2

    Protein attributes for TMEM11 Gene

    Size:
    192 amino acids
    Molecular mass:
    21541 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM11 Gene

Proteomics data for TMEM11 Gene at MOPED

Post-translational modifications for TMEM11 Gene

  • Ubiquitination at Lys142
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM11 Gene

Domains for TMEM11 Gene

Protein Domains for TMEM11 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P17152

UniProtKB/Swiss-Prot:

TMM11_HUMAN :
  • P17152
Family:
  • Belongs to the TMEM11 family.
genes like me logo Genes that share domains with TMEM11: view

No data available for Gene Families for TMEM11 Gene

Function for TMEM11 Gene

Molecular function for TMEM11 Gene

UniProtKB/Swiss-Prot Function: Plays a role in mitochondrial morphogenesis.

Gene Ontology (GO) - Molecular Function for TMEM11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with TMEM11: view

Phenotypes for TMEM11 Gene

GenomeRNAi human phenotypes for TMEM11:
genes like me logo Genes that share phenotypes with TMEM11: view

Animal Model Products

CRISPR Products

miRNA for TMEM11 Gene

miRTarBase miRNAs that target TMEM11

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM11

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM11 Gene

Localization for TMEM11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM11 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM11 Gene COMPARTMENTS Subcellular localization image for TMEM11 gene
Compartment Confidence
mitochondrion 5
plasma membrane 5
nucleus 2
peroxisome 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TMEM11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005887 integral component of plasma membrane NAS 2110658
GO:0031305 integral component of mitochondrial inner membrane IDA 21274005
genes like me logo Genes that share ontologies with TMEM11: view

Pathways for TMEM11 Gene

SuperPathways for TMEM11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007005 mitochondrion organization IMP 21274005
genes like me logo Genes that share ontologies with TMEM11: view

No data available for Pathways by source for TMEM11 Gene

Compounds for TMEM11 Gene

(1) Novoseek inferred chemical compound relationships for TMEM11 Gene

Compound -log(P) Hits PubMed IDs
calcium 0 2
genes like me logo Genes that share compounds with TMEM11: view

Transcripts for TMEM11 Gene

Unigene Clusters for TMEM11 Gene

Transmembrane protein 11:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM11

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM11 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
SP1: -
SP2:
SP3: - -
SP4: - - -

Relevant External Links for TMEM11 Gene

GeneLoc Exon Structure for
TMEM11
ECgene alternative splicing isoforms for
TMEM11

Expression for TMEM11 Gene

mRNA expression in normal human tissues for TMEM11 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM11 Gene

This gene is overexpressed in Muscle - Skeletal (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM11 Gene

SOURCE GeneReport for Unigene cluster for TMEM11 Gene Hs.592945

genes like me logo Genes that share expressions with TMEM11: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TMEM11 Gene

Orthologs for TMEM11 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM11 35
  • 100 (n)
  • 100 (a)
TMEM11 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM11 35
  • 91.67 (n)
  • 97.4 (a)
TMEM11 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM11 35
  • 94.79 (n)
  • 99.48 (a)
TMEM11 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem11 35
  • 91.23 (n)
  • 97.89 (a)
Tmem11 16
Tmem11 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM11 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM11 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem11 35
  • 91.93 (n)
  • 98.42 (a)
chicken
(Gallus gallus)
Aves TMEM11 35
  • 87.5 (n)
  • 95.83 (a)
TMEM11 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM11 36
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.14927 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6511 35
tmem11 35
  • 80.04 (n)
  • 90.91 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10266 35
zebrafish
(Danio rerio)
Actinopterygii Dr.16878 35
tmem11 35
  • 78.43 (n)
  • 83.42 (a)
tmem11 36
  • 84 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005550 35
  • 51.61 (n)
  • 42.58 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pmi 35
  • 54.78 (n)
  • 46.5 (a)
Pmi 36
  • 42 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13940 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11331 36
  • 49 (a)
OneToOne
Species with no ortholog for TMEM11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM11 Gene

ENSEMBL:
Gene Tree for TMEM11 (if available)
TreeFam:
Gene Tree for TMEM11 (if available)

Paralogs for TMEM11 Gene

No data available for Paralogs for TMEM11 Gene

Variants for TMEM11 Gene

Sequence variations from dbSNP and Humsavar for TMEM11 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1109513 -- 21,201,504(-) TGCTC(G/T)TGCAG intron-variant
rs1109514 -- 21,201,433(-) ACAGG(C/T)GGCTT intron-variant
rs1109515 -- 21,201,314(-) TAGCC(C/T)GGCTT intron-variant
rs1224542 -- 21,199,049(+) GGGTG(A/C/T)GGTGG intron-variant
rs2045467 -- 21,207,876(-) tgtct(C/T)gctct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM11 Gene

Variant ID Type Subtype PubMed ID
nsv907885 CNV Gain 21882294
esv2665619 CNV Deletion 23128226

Relevant External Links for TMEM11 Gene

HapMap Linkage Disequilibrium report
TMEM11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM11 Gene

Disorders for TMEM11 Gene

(2) University of Copenhagen DISEASES for TMEM11 Gene

(1) Novoseek inferred disease relationships for TMEM11 Gene

Disease -log(P) Hits PubMed IDs
leukemia 7.44 1

Relevant External Links for TMEM11

Genetic Association Database (GAD)
TMEM11
Human Genome Epidemiology (HuGE) Navigator
TMEM11
genes like me logo Genes that share disorders with TMEM11: view

No data available for UniProtKB/Swiss-Prot for TMEM11 Gene

Publications for TMEM11 Gene

  1. Inner-membrane proteins PMI/TMEM11 regulate mitochondrial morphogenesis independently of the DRP1/MFN fission/fusion pathways. (PMID: 21274005) Rival T. … Royet J. (EMBO Rep. 2011) 2 3 4
  2. Nucleotide sequence of a cDNA encoding a protein with primary structural similarity to G-protein coupled receptors. (PMID: 2110658) Murphy P.M. … Malech H.L. (Nucleic Acids Res. 1990) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for TMEM11 Gene

Sources for TMEM11 Gene

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