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Aliases for TMEM11 Gene

Aliases for TMEM11 Gene

  • Transmembrane Protein 11 2 3 5
  • C17orf35 3 4
  • PM1 3 4
  • Transmembrane Protein 11, Mitochondrial 3
  • Chromosome 17 Open Reading Frame 35 2
  • Putative Receptor Protein 3
  • Protein PM1 4
  • Protein PMI 4
  • PMI 3

External Ids for TMEM11 Gene

Previous HGNC Symbols for TMEM11 Gene

  • C17orf35

Previous GeneCards Identifiers for TMEM11 Gene

  • GC17M021042
  • GC17M020303

Summaries for TMEM11 Gene

GeneCards Summary for TMEM11 Gene

TMEM11 (Transmembrane Protein 11) is a Protein Coding gene. Diseases associated with TMEM11 include Penicilliosis.

UniProtKB/Swiss-Prot for TMEM11 Gene

  • Plays a role in mitochondrial morphogenesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM11 Gene

Genomics for TMEM11 Gene

Regulatory Elements for TMEM11 Gene

Enhancers for TMEM11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F021192 0.6 ENCODE 13.2 +21.7 21736 1.1 SCRT1 STAT1 HLF ENSG00000235530 TMEM11 DHRS7B FAM106B USP22 GC17M021160
GH17F021193 0.4 ENCODE 13.2 +20.2 20160 1.8 ZNF335 CTBP1 ZBTB48 ZNF600 PRDM1 NR2C2 TMEM11 DHRS7B FAM106B ENSG00000235530 GC17M021160
GH17F021240 1 Ensembl ENCODE 13.1 -25.9 -25877 0.2 SCRT2 ENSG00000235530 TMEM11 DHRS7B PIR36411 GC17M021230 RN7SL426P
GH17F021242 0.5 ENCODE 13.1 -28.8 -28806 1.6 MNT PPARG ZIC2 TMEM11 ENSG00000235530 DHRS7B OLA1P2 PIR52097 NATD1
GH17F021241 0.6 ENCODE 13.1 -27.5 -27460 0.5 ZNF664 ZNF687 MNT TMEM11 ENSG00000235530 DHRS7B PIR36411 PIR52097
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TMEM11 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001342819 424 2801 PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143

Genomic Location for TMEM11 Gene

21,197,280 bp from pter
21,214,624 bp from pter
17,345 bases
Minus strand

Genomic View for TMEM11 Gene

Genes around TMEM11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM11 Gene

Proteins for TMEM11 Gene

  • Protein details for TMEM11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 11, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q53YB2

    Protein attributes for TMEM11 Gene

    192 amino acids
    Molecular mass:
    21541 Da
    Quaternary structure:
    • Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MINOS1/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1, MTX2 and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. Interacts with IMMT/MIC60.

neXtProt entry for TMEM11 Gene

Post-translational modifications for TMEM11 Gene

  • Ubiquitination at Lys 142
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM11 Gene

Domains & Families for TMEM11 Gene

Protein Domains for TMEM11 Gene


Suggested Antigen Peptide Sequences for TMEM11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM11 family.
  • Belongs to the TMEM11 family.
genes like me logo Genes that share domains with TMEM11: view

No data available for Gene Families for TMEM11 Gene

Function for TMEM11 Gene

Molecular function for TMEM11 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in mitochondrial morphogenesis.

Gene Ontology (GO) - Molecular Function for TMEM11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with TMEM11: view
genes like me logo Genes that share phenotypes with TMEM11: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM11 Gene

Localization for TMEM11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM11 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMEM11 Gene COMPARTMENTS Subcellular localization image for TMEM11 gene
Compartment Confidence
mitochondrion 5
plasma membrane 5
peroxisome 2
cytosol 1
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TMEM11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane IEA --
GO:0005887 integral component of plasma membrane NAS 2110658
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM11: view

Pathways & Interactions for TMEM11 Gene

SuperPathways for TMEM11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007005 mitochondrion organization IEA,IMP 21274005
genes like me logo Genes that share ontologies with TMEM11: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM11 Gene

Drugs & Compounds for TMEM11 Gene

(1) Drugs for TMEM11 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TMEM11: view

Transcripts for TMEM11 Gene

Unigene Clusters for TMEM11 Gene

Transmembrane protein 11:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM11 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
SP1: -
SP3: - -
SP4: - - -

Relevant External Links for TMEM11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM11 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM11 Gene

This gene is overexpressed in Muscle - Skeletal (x4.6).

Protein differential expression in normal tissues from HIPED for TMEM11 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM11 Gene

Protein tissue co-expression partners for TMEM11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM11 Gene:


SOURCE GeneReport for Unigene cluster for TMEM11 Gene:

genes like me logo Genes that share expression patterns with TMEM11: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TMEM11 Gene

Orthologs for TMEM11 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM11 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM11 34 35
  • 100 (n)
(Monodelphis domestica)
Mammalia TMEM11 35
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM11 35
  • 97 (a)
(Canis familiaris)
Mammalia TMEM11 34 35
  • 94.79 (n)
(Rattus norvegicus)
Mammalia Tmem11 34
  • 91.93 (n)
(Bos Taurus)
Mammalia TMEM11 34 35
  • 91.67 (n)
(Mus musculus)
Mammalia Tmem11 34 16 35
  • 91.23 (n)
(Gallus gallus)
Aves TMEM11 34 35
  • 87.5 (n)
(Anolis carolinensis)
Reptilia TMEM11 35
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem11 34
  • 80.04 (n)
Str.6511 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.14927 34
(Danio rerio)
Actinopterygii tmem11 34 35
  • 78.43 (n)
Dr.16878 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10266 34
fruit fly
(Drosophila melanogaster)
Insecta Pmi 34 35
  • 54.78 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005550 34
  • 51.61 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11331 35
  • 49 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13940 34
Species where no ortholog for TMEM11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM11 Gene

Gene Tree for TMEM11 (if available)
Gene Tree for TMEM11 (if available)

Paralogs for TMEM11 Gene

No data available for Paralogs for TMEM11 Gene

Variants for TMEM11 Gene

Sequence variations from dbSNP and Humsavar for TMEM11 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1109513 -- 21,201,504(-) TGCTC(G/T)TGCAG intron-variant
rs1109514 -- 21,201,433(-) ACAGG(C/T)GGCTT intron-variant
rs1109515 -- 21,201,314(-) TAGCC(C/T)GGCTT intron-variant
rs111244431 -- 21,198,936(+) GGTCT(C/G)AGCCT intron-variant
rs111253411 -- 21,212,843(+) AACCA(C/T)TGAGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM11 Gene

Variant ID Type Subtype PubMed ID
esv2665619 CNV deletion 23128226
esv3554255 CNV deletion 23714750
esv3582570 CNV loss 25503493
esv3640229 CNV loss 21293372
nsv1059146 CNV gain 25217958
nsv1059210 CNV gain 25217958
nsv1078306 OTHER inversion 25765185

Variation tolerance for TMEM11 Gene

Residual Variation Intolerance Score: 23.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.28; 6.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM11 Gene

Disorders for TMEM11 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMEM11 Gene - From: DISEASES

Disorder Aliases PubMed IDs
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TMEM11

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TMEM11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM11 Gene

Publications for TMEM11 Gene

  1. Inner-membrane proteins PMI/TMEM11 regulate mitochondrial morphogenesis independently of the DRP1/MFN fission/fusion pathways. (PMID: 21274005) Rival T. … Royet J. (EMBO Rep. 2011) 2 3 4 64
  2. Nucleotide sequence of a cDNA encoding a protein with primary structural similarity to G-protein coupled receptors. (PMID: 2110658) Murphy P.M. … Malech H.L. (Nucleic Acids Res. 1990) 2 3 4 64
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Pooled-matrix protein interaction screens using Barcode Fusion Genetics. (PMID: 27107012) Yachie N. … Roth F.P. (Mol. Syst. Biol. 2016) 3 64

Products for TMEM11 Gene

Sources for TMEM11 Gene

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