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Aliases for TMEM11 Gene

Aliases for TMEM11 Gene

  • Transmembrane Protein 11 2 3 5
  • C17orf35 3 4
  • PM1 3 4
  • Chromosome 17 Open Reading Frame 35 2
  • Putative Receptor Protein 3
  • Protein PM1 4
  • Protein PMI 4
  • PMI 3

External Ids for TMEM11 Gene

Previous HGNC Symbols for TMEM11 Gene

  • C17orf35

Previous GeneCards Identifiers for TMEM11 Gene

  • GC17M021042
  • GC17M020303

Summaries for TMEM11 Gene

GeneCards Summary for TMEM11 Gene

TMEM11 (Transmembrane Protein 11) is a Protein Coding gene. Diseases associated with TMEM11 include penicilliosis.

UniProtKB/Swiss-Prot for TMEM11 Gene

  • Plays a role in mitochondrial morphogenesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM11 Gene

Genomics for TMEM11 Gene

Regulatory Elements for TMEM11 Gene

Promoters for TMEM11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM11 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM11 Gene

Chromosome:
17
Start:
21,197,280 bp from pter
End:
21,214,624 bp from pter
Size:
17,345 bases
Orientation:
Minus strand

Genomic View for TMEM11 Gene

Genes around TMEM11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM11 Gene

Proteins for TMEM11 Gene

  • Protein details for TMEM11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17152-TMM11_HUMAN
    Recommended name:
    Transmembrane protein 11, mitochondrial
    Protein Accession:
    P17152
    Secondary Accessions:
    • Q53YB2

    Protein attributes for TMEM11 Gene

    Size:
    192 amino acids
    Molecular mass:
    21541 Da
    Quaternary structure:
    • Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MINOS1/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1, MTX2 and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. Interacts with IMMT/MIC60.

neXtProt entry for TMEM11 Gene

Proteomics data for TMEM11 Gene at MOPED

Post-translational modifications for TMEM11 Gene

  • Ubiquitination at Lys 142
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM11 Gene

Domains & Families for TMEM11 Gene

Protein Domains for TMEM11 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P17152

UniProtKB/Swiss-Prot:

TMM11_HUMAN :
  • Belongs to the TMEM11 family.
Family:
  • Belongs to the TMEM11 family.
genes like me logo Genes that share domains with TMEM11: view

No data available for Gene Families for TMEM11 Gene

Function for TMEM11 Gene

Molecular function for TMEM11 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in mitochondrial morphogenesis.

Gene Ontology (GO) - Molecular Function for TMEM11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM11: view
genes like me logo Genes that share phenotypes with TMEM11: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM11 Gene

Localization for TMEM11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM11 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM11 Gene COMPARTMENTS Subcellular localization image for TMEM11 gene
Compartment Confidence
mitochondrion 5
plasma membrane 5
peroxisome 2
cytosol 1
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TMEM11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0031305 integral component of mitochondrial inner membrane IEA,IDA 21274005
genes like me logo Genes that share ontologies with TMEM11: view

Pathways & Interactions for TMEM11 Gene

SuperPathways for TMEM11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM11 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM11 Gene

Drugs & Compounds for TMEM11 Gene

(1) Drugs for TMEM11 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TMEM11: view

Transcripts for TMEM11 Gene

Unigene Clusters for TMEM11 Gene

Transmembrane protein 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM11 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
SP1: -
SP2:
SP3: - -
SP4: - - -

Relevant External Links for TMEM11 Gene

GeneLoc Exon Structure for
TMEM11
ECgene alternative splicing isoforms for
TMEM11

Expression for TMEM11 Gene

mRNA expression in normal human tissues for TMEM11 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM11 Gene

This gene is overexpressed in Muscle - Skeletal (x4.6).

Protein differential expression in normal tissues from HIPED for TMEM11 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM11 Gene



SOURCE GeneReport for Unigene cluster for TMEM11 Gene Hs.592945

genes like me logo Genes that share expression patterns with TMEM11: view

Protein tissue co-expression partners for TMEM11 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TMEM11 Gene

Orthologs for TMEM11 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM11 35
  • 91.67 (n)
  • 97.4 (a)
TMEM11 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM11 35
  • 94.79 (n)
  • 99.48 (a)
TMEM11 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem11 35
  • 91.23 (n)
  • 97.89 (a)
Tmem11 16
Tmem11 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM11 35
  • 100 (n)
  • 100 (a)
TMEM11 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem11 35
  • 91.93 (n)
  • 98.42 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM11 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM11 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM11 35
  • 87.5 (n)
  • 95.83 (a)
TMEM11 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM11 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6511 35
tmem11 35
  • 80.04 (n)
  • 90.91 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14927 35
zebrafish
(Danio rerio)
Actinopterygii Dr.16878 35
tmem11 35
  • 78.43 (n)
  • 83.42 (a)
tmem11 36
  • 84 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10266 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005550 35
  • 51.61 (n)
  • 42.58 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pmi 35
  • 54.78 (n)
  • 46.5 (a)
Pmi 36
  • 42 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13940 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11331 36
  • 49 (a)
OneToOne
Species with no ortholog for TMEM11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM11 Gene

ENSEMBL:
Gene Tree for TMEM11 (if available)
TreeFam:
Gene Tree for TMEM11 (if available)

Paralogs for TMEM11 Gene

No data available for Paralogs for TMEM11 Gene

Variants for TMEM11 Gene

Sequence variations from dbSNP and Humsavar for TMEM11 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1109513 -- 21,201,504(-) TGCTC(G/T)TGCAG intron-variant
rs1109514 -- 21,201,433(-) ACAGG(C/T)GGCTT intron-variant
rs1109515 -- 21,201,314(-) TAGCC(C/T)GGCTT intron-variant
rs1224542 -- 21,199,049(+) GGGTG(A/C/T)GGTGG intron-variant
rs2045467 -- 21,207,876(-) tgtct(C/T)gctct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM11 Gene

Variant ID Type Subtype PubMed ID
nsv907885 CNV Gain 21882294
esv2665619 CNV Deletion 23128226

Variation tolerance for TMEM11 Gene

Residual Variation Intolerance Score: 23.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.28; 6.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM11 Gene

HapMap Linkage Disequilibrium report
TMEM11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM11 Gene

Disorders for TMEM11 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMEM11 Gene - From: DISEASES

Disorder Aliases PubMed IDs
penicilliosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TMEM11

Genetic Association Database (GAD)
TMEM11
Human Genome Epidemiology (HuGE) Navigator
TMEM11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM11
genes like me logo Genes that share disorders with TMEM11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM11 Gene

Publications for TMEM11 Gene

  1. Inner-membrane proteins PMI/TMEM11 regulate mitochondrial morphogenesis independently of the DRP1/MFN fission/fusion pathways. (PMID: 21274005) Rival T. … Royet J. (EMBO Rep. 2011) 2 3 4 67
  2. Nucleotide sequence of a cDNA encoding a protein with primary structural similarity to G-protein coupled receptors. (PMID: 2110658) Murphy P.M. … Malech H.L. (Nucleic Acids Res. 1990) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Identifying protein partners of CLN8, an ER-resident protein involved in neuronal ceroid lipofuscinosis. (PMID: 23142642) Passantino R. … Guarneri P. (Biochim. Biophys. Acta 2013) 3

Products for TMEM11 Gene

Sources for TMEM11 Gene

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