Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMEM109 Gene

Aliases for TMEM109 Gene

  • Transmembrane Protein 109 2 3 5
  • Mitsugumin-23 3 4
  • Mg23 3 4

External Ids for TMEM109 Gene

Previous GeneCards Identifiers for TMEM109 Gene

  • GC11P060439
  • GC11P060681
  • GC11P057027

Summaries for TMEM109 Gene

GeneCards Summary for TMEM109 Gene

TMEM109 (Transmembrane Protein 109) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM109 Gene

  • May mediate cellular response to DNA damage by protecting against ultraviolet C-induced cell death (PubMed:23542032). Can form voltage-gated calcium and potassium channels in vitro (By similarity).

Additional gene information for TMEM109 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM109 Gene

Genomics for TMEM109 Gene

Regulatory Elements for TMEM109 Gene

Enhancers for TMEM109 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H060840 1.4 ENCODE dbSUPER 11.3 -70.6 -70627 5.9 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 TMEM109 PRPF19 CCDC86 PTGDR2 SLC15A3 ENSG00000255959 PIR48769 GC11P060851
GH11H060376 1.4 Ensembl ENCODE dbSUPER 11.2 -535.8 -535806 2.9 PKNOX1 BATF YY1 FOS ETV6 RUNX3 CREM IKZF2 GATAD2B ELF1 MS4A14 MS4A1 TMEM109 MS4A7 GC11P060374
GH11H060904 1.3 ENCODE dbSUPER 11.5 -7.9 -7911 3.3 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143 MXD4 NFYC TMEM109 PRPF19 PTGDR2 PIR47747
GH11H061428 1.3 ENCODE dbSUPER 10.9 +516.1 516057 3.3 PKNOX1 MLX ARID4B SIN3A YBX1 DMAP1 ZNF2 ZBTB7B YY1 ZNF207 CPSF7 TMEM216 VPS37C TMEM138 RN7SL23P TMEM109 DDB1 TKFC SDHAF2 ENSG00000256591
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM109 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM109 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000040164 826 2201 HDGF SIN3A FEZF1 YY1 ZNF766 ZNF416 ZNF207 ZNF143 FOS DEK

Genomic Locations for TMEM109 Gene

Genomic Locations for TMEM109 Gene
9,570 bases
Plus strand

Genomic View for TMEM109 Gene

Genes around TMEM109 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM109 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM109 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM109 Gene

Proteins for TMEM109 Gene

  • Protein details for TMEM109 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 109
    Protein Accession:

    Protein attributes for TMEM109 Gene

    243 amino acids
    Molecular mass:
    26210 Da
    Quaternary structure:
    • Homooligomer (By similarity). Interacts with CRYAB (PubMed:23542032).

neXtProt entry for TMEM109 Gene

Post-translational modifications for TMEM109 Gene

  • Ubiquitination at Lys215
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM109 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM109 Gene

Domains & Families for TMEM109 Gene

Gene Families for TMEM109 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for TMEM109 Gene


Suggested Antigen Peptide Sequences for TMEM109 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM109: view

No data available for UniProtKB/Swiss-Prot for TMEM109 Gene

Function for TMEM109 Gene

Molecular function for TMEM109 Gene

UniProtKB/Swiss-Prot Function:
May mediate cellular response to DNA damage by protecting against ultraviolet C-induced cell death (PubMed:23542032). Can form voltage-gated calcium and potassium channels in vitro (By similarity).

Phenotypes From GWAS Catalog for TMEM109 Gene

Gene Ontology (GO) - Molecular Function for TMEM109 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005244 voltage-gated ion channel activity IEA --
genes like me logo Genes that share ontologies with TMEM109: view
genes like me logo Genes that share phenotypes with TMEM109: view

Animal Models for TMEM109 Gene

MGI Knock Outs for TMEM109:

Animal Model Products

CRISPR Products

miRNA for TMEM109 Gene

miRTarBase miRNAs that target TMEM109

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM109 Gene

Localization for TMEM109 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM109 Gene

Nucleus outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM109 gene
Compartment Confidence
extracellular 5
nucleus 4
endoplasmic reticulum 4
plasma membrane 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM109 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005640 nuclear outer membrane IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TMEM109: view

Pathways & Interactions for TMEM109 Gene

SuperPathways for TMEM109 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM109 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA --
GO:0060548 negative regulation of cell death IMP 23542032
genes like me logo Genes that share ontologies with TMEM109: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM109 Gene

Drugs & Compounds for TMEM109 Gene

No Compound Related Data Available

Transcripts for TMEM109 Gene

mRNA/cDNA for TMEM109 Gene

Unigene Clusters for TMEM109 Gene

Transmembrane protein 109:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM109 Gene

No ASD Table

Relevant External Links for TMEM109 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM109 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM109 Gene

Protein differential expression in normal tissues from HIPED for TMEM109 Gene

This gene is overexpressed in Nasal epithelium (24.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM109 Gene

Protein tissue co-expression partners for TMEM109 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM109 Gene:


SOURCE GeneReport for Unigene cluster for TMEM109 Gene:


Evidence on tissue expression from TISSUES for TMEM109 Gene

  • Blood(4.1)
  • Nervous system(3.2)
  • Skin(3)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with TMEM109: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM109 Gene

Orthologs for TMEM109 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM109 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM109 33 34
  • 99.45 (n)
(Canis familiaris)
Mammalia TMEM109 33 34
  • 86.56 (n)
(Bos Taurus)
Mammalia TMEM109 33 34
  • 85.46 (n)
(Rattus norvegicus)
Mammalia Tmem109 33
  • 79.7 (n)
(Mus musculus)
Mammalia Tmem109 33 16 34
  • 78.74 (n)
(Monodelphis domestica)
Mammalia TMEM109 34
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM109 34
  • 59 (a)
(Anolis carolinensis)
Reptilia TMEM109 34
  • 44 (a)
Species where no ortholog for TMEM109 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM109 Gene

Gene Tree for TMEM109 (if available)
Gene Tree for TMEM109 (if available)

Paralogs for TMEM109 Gene

No data available for Paralogs for TMEM109 Gene

Variants for TMEM109 Gene

Sequence variations from dbSNP and Humsavar for TMEM109 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000342054 -- 60,923,591(+) TCCAG(A/G)AGCAC intron-variant, upstream-variant-2KB
rs1000544818 -- 60,921,287(+) ATGGT(A/G)GCGTG intron-variant
rs1000671663 -- 60,914,371(+) GTCCG(A/C/G)GTGGG intron-variant, upstream-variant-2KB
rs1000832344 -- 60,918,040(+) CAATG(G/T)CAGAA intron-variant
rs1001217065 -- 60,915,326(+) GGTTA(A/G)GTAAC intron-variant, upstream-variant-2KB

Variation tolerance for TMEM109 Gene

Residual Variation Intolerance Score: 38.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.68; 32.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM109 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMEM109 Gene

Disorders for TMEM109 Gene

Relevant External Links for TMEM109

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMEM109 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM109 Gene

Publications for TMEM109 Gene

  1. Protective role of the endoplasmic reticulum protein mitsugumin23 against ultraviolet C-induced cell death. (PMID: 23542032) Yamashita A … Yamazaki T (FEBS letters 2013) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W … Gibbs RA (Genome research 1997) 2 3 60
  4. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B … Gibbs RA (Analytical biochemistry 1996) 2 3 60
  5. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R … Boisvert FM (Molecular & cellular proteomics : MCP 2015) 3 60

Products for TMEM109 Gene

Sources for TMEM109 Gene

Loading form....