TMEM109 Gene
protein-coding GIFtS: 40
GCID: GC11P060681
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transmembrane protein 109
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Aliases
for TMEM109 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protein 1091 2 | | MGC55081 | | Mg233 | | Mitsugumin-233 | | Mg233 | | Mitsugumin-233 |
Export aliases for TMEM109 gene to outside databasesPrevious GC identifers: GC11P060439 GC11P057027 |
Summaries
for TMEM109 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TMEM109 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMEM109 gene promoter:
COUP-TF1 CREB COUP-TF deltaCREB COUP Lmo2 AP-4 HNF-4alpha1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM109
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM109 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q12.2 Ensembl cytogenetic band: 11q12.2 HGNC cytogenetic band: 11q12.2TMEM109 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P060681: view genomic region
(about GC identifiers)
Start:
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60,681,346 bp from pter |
End:
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60,690,915 bp from pter |
Size:
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9,570 bases |
Orientation:
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plus strand |
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Proteins
for TMEM109 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TM109_HUMAN, Q9BVC6 (See
protein sequence)Recommended Name: Transmembrane protein 109 precursor Size: 243 amino acids; 26210 Da
Subcellular location: Nucleus outer membrane; Multi-pass membrane protein (By similarity). Endoplasmic reticulummembrane; Multi-pass membrane protein (By similarity). Sarcoplasmic reticulum membrane; Multi-pass membrane protein(By similarity)Explore the universe of human proteins at neXtProt for TMEM109: NX_Q9BVC6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BVC6
TMEM109 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_076997.1
ENSEMBL proteins: ENSP00000227525 ENSP00000437828 ENSP00000443990
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
TMEM109 for ontologies About GeneDecksing
TMEM109 Antibody Products:
Assay Products for TMEM109: |
Protein
Domains /
Families
for TMEM109 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9BVC6 |
Function
for TMEM109 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM109 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM109 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TMEM109 (NM_024092) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM109 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM109 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM109 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
TMEM109 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for TMEM109:
Animal Models:
Mouse knock-out Tmem109tm1Yamt for TMEM109
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Tmem109):
TMEM109 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TMEM109 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM109
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
5/6 Interacting proteins for TMEM109 (Q9BVC63 ENSP000002275254) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- | | GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
IEA | -- |
TMEM109 for ontologies About GeneDecksing
|
Drugs & Compounds
for TMEM109 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM109
Search CenterWatch for drugs/clinical trials and news about TMEM109 / TM109
|
Transcripts
for TMEM109 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMEM109 gene: NM_024092.2 Unigene Cluster for TMEM109: Transmembrane protein 109 Hs.13662 [show with all ESTs]Unigene Representative Sequence: NM_0240924 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000227525(uc001nqg.3) ENST00000540407 ENST00000536171 ENST00000540280
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM109 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM109 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TMEM109 (NM_024092) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM109 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM109 |
Additional cDNA sequence: AF131803.1 AK303961.1 AK313913.1 BC001309.1 15 DOTS entries: DT.100803576 DT.218800 DT.102837368 DT.99947781 DT.100803591 DT.92448706 DT.87013205 DT.120716029 DT.100803586 DT.120716144 DT.120716215 DT.95265000 DT.95265011 DT.120716152 DT.87011908 24/478 AceView cDNA sequences (see all 478): CB158110 F27845 AA279587 BM719392 AL517776 AI983591 BM912375 AW339010 AA730996 BG574547 BM915517 BU688210 AW055074 AI826752 BI835664 CR621258 AW591378 BU633037 AW316567 BM913335 AA709392 BM782146 BF344630 AW439738
GeneLoc Exon Structure
|
Expression
for TMEM109 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM109 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGTGAAGAA
About this image
See TMEM109 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM109
SOURCE GeneReport for Unigene cluster: Hs.13662
SABiosciences Custom PCR Arrays for TMEM109
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM109
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM109 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM109 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM109 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM109 |
Orthologs
for TMEM109 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TMEM109 gene from 3/9 species (see all 9) About this table
ENSEMBL Gene Tree for TMEM109 (if available)
TreeFam Gene Tree for TMEM109 (if available) |
Paralogs
for TMEM109 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TMEM109 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM109 (60681346 - 60690915 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TMEM109: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM109 |
|
Disorders
/ Diseases
for TMEM109 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for TMEM109 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM109 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with TMEM109) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 3 Yu W.... Gibbs R.A. (1997)
- A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (1996)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Facilitation of DNA damage-induced apoptosis by endop lasmic reticulum protein mitsugumin23. (PubMed id 20060811)1 Yamazaki T....Takeshima H. (2010)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
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External Searches for TMEM109 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMEM109 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMEM109 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM109 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM109 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMEM109 gene:
Search GeneIP for patents involving TMEM109
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM109 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TMEM109 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM109 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM109 | | | OriGene Protein Over-expression Lysate for TMEM109 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMEM109 | | OriGene 3'-UTR Clone for TMEM109 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM109 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM109 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TMEM109 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM109 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM109 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM109 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM109 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM109 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM109 |
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 |  |  |  | |
| | | | Search Tocris compounds for TMEM109 |
| |  |  |  |  | | | | |
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 | | | TMEM109 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM109 |
|  |  |  | | | | Search ThermoFisher Antibodies for TMEM109 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM109 |
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