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Aliases for TMEM109 Gene

Aliases for TMEM109 Gene

  • Transmembrane Protein 109 2 3
  • Mitsugumin-23 3 4
  • Mg23 3 4

External Ids for TMEM109 Gene

Previous GeneCards Identifiers for TMEM109 Gene

  • GC11P060439
  • GC11P060681
  • GC11P057027

Summaries for TMEM109 Gene

GeneCards Summary for TMEM109 Gene

TMEM109 (Transmembrane Protein 109) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM109 Gene

Genomics for TMEM109 Gene

Regulatory Elements for TMEM109 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMEM109 Gene

60,913,874 bp from pter
60,923,443 bp from pter
9,570 bases
Plus strand

Genomic View for TMEM109 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM109 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM109 Gene

Proteins for TMEM109 Gene

  • Protein details for TMEM109 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 109
    Protein Accession:
    Secondary Accessions:

    Protein attributes for TMEM109 Gene

    243 amino acids
    Molecular mass:
    26210 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM109 Gene

Proteomics data for TMEM109 Gene at MOPED

Post-translational modifications for TMEM109 Gene

  • Ubiquitination at Lys215
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM109 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM109 Gene

Domains for TMEM109 Gene

Protein Domains for TMEM109 Gene


Suggested Antigen Peptide Sequences for TMEM109 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM109: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM109 Gene

Function for TMEM109 Gene

Gene Ontology (GO) - Molecular Function for TMEM109 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TMEM109: view

Phenotypes for TMEM109 Gene

MGI mutant phenotypes for TMEM109:
inferred from 1 alleles
GenomeRNAi human phenotypes for TMEM109:
genes like me logo Genes that share phenotypes with TMEM109: view

Animal Models for TMEM109 Gene

MGI Knock Outs for TMEM109:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM109

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TMEM109 Gene

Localization for TMEM109 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM109 Gene

Nucleus outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMEM109 Gene COMPARTMENTS Subcellular localization image for TMEM109 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 5
cytosol 3
extracellular 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for TMEM109 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005640 nuclear outer membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016529 sarcoplasmic reticulum --
GO:0033017 sarcoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with TMEM109: view

Pathways for TMEM109 Gene

SuperPathways for TMEM109 Gene

No Data Available

Interacting Proteins for TMEM109 Gene

Gene Ontology (GO) - Biological Process for TMEM109 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA --
GO:0060548 negative regulation of cell death IMP 23269685
GO:0071480 cellular response to gamma radiation IMP 23269685
genes like me logo Genes that share ontologies with TMEM109: view

No data available for Pathways by source for TMEM109 Gene

Transcripts for TMEM109 Gene

mRNA/cDNA for TMEM109 Gene

Unigene Clusters for TMEM109 Gene

Transmembrane protein 109:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM109

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM109 Gene

No ASD Table

Relevant External Links for TMEM109 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM109 Gene

mRNA expression in normal human tissues for TMEM109 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM109 Gene

SOURCE GeneReport for Unigene cluster for TMEM109 Gene Hs.13662

genes like me logo Genes that share expressions with TMEM109: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM109 Gene

Orthologs for TMEM109 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM109 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM109 35
  • 99.45 (n)
  • 99.18 (a)
TMEM109 36
  • 99 (a)
(Bos Taurus)
Mammalia TMEM109 35
  • 85.46 (n)
  • 83.13 (a)
TMEM109 36
  • 83 (a)
(Canis familiaris)
Mammalia TMEM109 35
  • 86.56 (n)
  • 86.42 (a)
TMEM109 36
  • 86 (a)
(Mus musculus)
Mammalia Tmem109 35
  • 78.74 (n)
  • 75.31 (a)
Tmem109 16
Tmem109 36
  • 75 (a)
(Monodelphis domestica)
Mammalia TMEM109 36
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM109 36
  • 59 (a)
(Rattus norvegicus)
Mammalia Tmem109 35
  • 79.7 (n)
  • 74.49 (a)
(Anolis carolinensis)
Reptilia TMEM109 36
  • 44 (a)
Species with no ortholog for TMEM109:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM109 Gene

Gene Tree for TMEM109 (if available)
Gene Tree for TMEM109 (if available)

Paralogs for TMEM109 Gene

No data available for Paralogs for TMEM109 Gene

Variants for TMEM109 Gene

Sequence variations from dbSNP and Humsavar for TMEM109 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs511399 -- 60,918,285(-) agtgg(C/T)attct intron-variant
rs514891 -- 60,918,648(+) GAGGG(A/G)AATGG intron-variant
rs555835 -- 60,921,973(+) GTGCC(C/T)GACCC synonymous-codon, reference
rs557433 -- 60,918,621(-) CCCTT(C/T)TCCAC intron-variant
rs668671 -- 60,912,730(-) actcc(C/T)tccca upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM109 Gene

Variant ID Type Subtype PubMed ID
nsv897599 CNV Loss 21882294
nsv897600 CNV Gain 21882294
nsv897601 CNV Loss 21882294

Relevant External Links for TMEM109 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM109 Gene

Disorders for TMEM109 Gene

No disorders were found for TMEM109 Gene.

No data available for UniProtKB/Swiss-Prot for TMEM109 Gene

Publications for TMEM109 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3
  3. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 2 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for TMEM109 Gene

  • antibodies-online peptides for TMEM109
  • antibodies-online antibodies for TMEM109
  • antibodies-online kits for TMEM109

Sources for TMEM109 Gene

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