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Aliases for TMEM109 Gene

Aliases for TMEM109 Gene

  • Transmembrane Protein 109 2 3 5
  • Mitsugumin-23 3 4
  • Mg23 3 4

External Ids for TMEM109 Gene

Previous GeneCards Identifiers for TMEM109 Gene

  • GC11P060439
  • GC11P060681
  • GC11P057027

Summaries for TMEM109 Gene

GeneCards Summary for TMEM109 Gene

TMEM109 (Transmembrane Protein 109) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM109 Gene

  • May mediate cellular response to DNA damage by protecting against ultraviolet C-induced cell death (PubMed:23542032). Can form voltage-gated calcium and potassium channels in vitro (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM109 Gene

Genomics for TMEM109 Gene

Regulatory Elements for TMEM109 Gene

Promoters for TMEM109 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM109 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM109 Gene

Chromosome:
11
Start:
60,913,874 bp from pter
End:
60,923,443 bp from pter
Size:
9,570 bases
Orientation:
Plus strand

Genomic View for TMEM109 Gene

Genes around TMEM109 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM109 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM109 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM109 Gene

Proteins for TMEM109 Gene

  • Protein details for TMEM109 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BVC6-TM109_HUMAN
    Recommended name:
    Transmembrane protein 109
    Protein Accession:
    Q9BVC6

    Protein attributes for TMEM109 Gene

    Size:
    243 amino acids
    Molecular mass:
    26210 Da
    Quaternary structure:
    • Homooligomer (By similarity). Interacts with CRYAB (PubMed:23542032).

neXtProt entry for TMEM109 Gene

Proteomics data for TMEM109 Gene at MOPED

Post-translational modifications for TMEM109 Gene

  • Ubiquitination at Lys 215
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM109 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM109 Gene

Domains & Families for TMEM109 Gene

Protein Domains for TMEM109 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TMEM109 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM109: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM109 Gene

Function for TMEM109 Gene

Molecular function for TMEM109 Gene

UniProtKB/Swiss-Prot Function:
May mediate cellular response to DNA damage by protecting against ultraviolet C-induced cell death (PubMed:23542032). Can form voltage-gated calcium and potassium channels in vitro (By similarity).

Gene Ontology (GO) - Molecular Function for TMEM109 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with TMEM109: view
genes like me logo Genes that share phenotypes with TMEM109: view

Animal Models for TMEM109 Gene

MGI Knock Outs for TMEM109:

Animal Model Products

miRNA for TMEM109 Gene

miRTarBase miRNAs that target TMEM109

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM109 Gene

Localization for TMEM109 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM109 Gene

Nucleus outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM109 Gene COMPARTMENTS Subcellular localization image for TMEM109 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
nucleus 4
cytosol 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for TMEM109 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005640 nuclear outer membrane IEA --
genes like me logo Genes that share ontologies with TMEM109: view

Pathways & Interactions for TMEM109 Gene

SuperPathways for TMEM109 Gene

No Data Available

Interacting Proteins for TMEM109 Gene

Gene Ontology (GO) - Biological Process for TMEM109 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0060548 negative regulation of cell death IMP 23542032
GO:0071480 cellular response to gamma radiation IMP 23542032
genes like me logo Genes that share ontologies with TMEM109: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM109 Gene

Drugs & Compounds for TMEM109 Gene

No Compound Related Data Available

Transcripts for TMEM109 Gene

mRNA/cDNA for TMEM109 Gene

Unigene Clusters for TMEM109 Gene

Transmembrane protein 109:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM109 Gene

No ASD Table

Relevant External Links for TMEM109 Gene

GeneLoc Exon Structure for
TMEM109
ECgene alternative splicing isoforms for
TMEM109

Expression for TMEM109 Gene

mRNA expression in normal human tissues for TMEM109 Gene

Protein differential expression in normal tissues from HIPED for TMEM109 Gene

This gene is overexpressed in Nasal epithelium (24.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM109 Gene



SOURCE GeneReport for Unigene cluster for TMEM109 Gene Hs.13662

genes like me logo Genes that share expression patterns with TMEM109: view

Protein tissue co-expression partners for TMEM109 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM109 Gene

Orthologs for TMEM109 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM109 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM109 35
  • 99.45 (n)
  • 99.18 (a)
TMEM109 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM109 36
  • 83 (a)
OneToOne
TMEM109 35
  • 85.46 (n)
  • 83.13 (a)
dog
(Canis familiaris)
Mammalia TMEM109 35
  • 86.56 (n)
  • 86.42 (a)
TMEM109 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem109 16
Tmem109 36
  • 75 (a)
OneToOne
Tmem109 35
  • 78.74 (n)
  • 75.31 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM109 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM109 36
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem109 35
  • 79.7 (n)
  • 74.49 (a)
lizard
(Anolis carolinensis)
Reptilia TMEM109 36
  • 44 (a)
OneToOne
Species with no ortholog for TMEM109:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM109 Gene

ENSEMBL:
Gene Tree for TMEM109 (if available)
TreeFam:
Gene Tree for TMEM109 (if available)

Paralogs for TMEM109 Gene

No data available for Paralogs for TMEM109 Gene

Variants for TMEM109 Gene

Sequence variations from dbSNP and Humsavar for TMEM109 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs514891 -- 60,918,648(+) GAGGG(A/G)AATGG intron-variant
rs557433 -- 60,918,621(-) CCCTT(C/T)TCCAC intron-variant
rs2301726 -- 60,919,803(-) AGTCT(C/T)GACGG reference, missense
rs4938991 -- 60,917,868(+) ATGTT(A/G)CCCAG intron-variant
rs4939478 -- 60,920,100(+) TGATT(C/G)CTGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM109 Gene

Variant ID Type Subtype PubMed ID
nsv897599 CNV Loss 21882294
nsv897600 CNV Gain 21882294
nsv897601 CNV Loss 21882294

Variation tolerance for TMEM109 Gene

Residual Variation Intolerance Score: 38.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.68; 32.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM109 Gene

HapMap Linkage Disequilibrium report
TMEM109

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM109 Gene

Disorders for TMEM109 Gene

Relevant External Links for TMEM109

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM109

No disorders were found for TMEM109 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM109 Gene

Publications for TMEM109 Gene

  1. Protective role of the endoplasmic reticulum protein mitsugumin23 against ultraviolet C-induced cell death. (PMID: 23542032) Yamashita A. … Yamazaki T. (FEBS Lett. 2013) 3 4 67
  2. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 2 3
  3. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3

Products for TMEM109 Gene

Sources for TMEM109 Gene

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