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Aliases for TMEM108 Gene

Aliases for TMEM108 Gene

  • Transmembrane Protein 108 2 3 5
  • Cancer/Testis Antigen 124 2 3
  • Retrolinkin 3 4
  • RTLN 3 4
  • KIAA1690 4
  • CT124 3

External Ids for TMEM108 Gene

Previous GeneCards Identifiers for TMEM108 Gene

  • GC03P134240
  • GC03P132757
  • GC03P130137

Summaries for TMEM108 Gene

GeneCards Summary for TMEM108 Gene

TMEM108 (Transmembrane Protein 108) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM108 Gene

  • Transmembrane protein required for proper cognitive functions. Involved in the development of dentate gyrus (DG) neuron circuitry, is neccessary for AMPA receptors surface expression and proper excitatory postsynaptic currents of DG granule neurons. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Through the interaction with DST, mediates the docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport. In hippocampal neurons, required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 and recruits the WAVE1 complex to facilitate actin-dependent BDNF:NTRK2 early endocytic trafficking and mediate signaling from early endosomes.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM108 Gene

Genomics for TMEM108 Gene

Regulatory Elements for TMEM108 Gene

Enhancers for TMEM108 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G133068 0.5 FANTOM5 15.8 +30.4 30425 0.1 PATZ1 FOXJ2 SP7 TMEM108 ENSG00000249725 TMEM108-AS1 UBA5
GH03G133384 0.7 ENCODE 11 +346.4 346354 0.2 CTCF MXI1 ZNF146 NFIB ZSCAN26 RAD21 ZNF143 SMC3 PRDM10 ZNF654 TMEM108 ENSG00000249725 TFP1 TMEM108-AS1 LOC101927432 GC03M133285
GH03G133300 0.6 ENCODE 10 +263.1 263134 1.9 JUND ZNF157 NFIB JUN CEBPG FOS MAFK TMEM108-AS1 ENSG00000249725 TMEM108 GC03M133285
GH03G133411 1.5 FANTOM5 Ensembl ENCODE dbSUPER 2.7 +374.9 374855 2.3 PKNOX1 FEZF1 HIC1 ZFHX2 CTBP1 ZNF316 ZSCAN5C ZNF600 NFE2 PRDM10 TMEM108 SRPRB ENSG00000249820 BFSP2-AS1
GH03G132972 0.4 ENCODE 10 -65.8 -65797 0.2 JUND ENSG00000249725 TMEM108 GC03P132823
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM108 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM108 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000158571 12 601 PKNOX1 ZNF777 ATF1 USF1 SUZ12 MAX ZNF2 HIC1 POLR2A NFYB

Genomic Location for TMEM108 Gene

Chromosome:
3
Start:
133,038,288 bp from pter
End:
133,397,792 bp from pter
Size:
359,505 bases
Orientation:
Plus strand

Genomic View for TMEM108 Gene

Genes around TMEM108 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM108 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM108 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM108 Gene

Proteins for TMEM108 Gene

  • Protein details for TMEM108 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXF1-TM108_HUMAN
    Recommended name:
    Transmembrane protein 108
    Protein Accession:
    Q6UXF1
    Secondary Accessions:
    • D3DNC9
    • Q9BQH1
    • Q9BW81
    • Q9C0H3

    Protein attributes for TMEM108 Gene

    Size:
    575 amino acids
    Molecular mass:
    59948 Da
    Quaternary structure:
    • Interacts with DST (isoform 1). Interacts with SH3GL2. Interacts (via N-terminus) with CYFIP1 and CYFIP2; the interactions associate TMEM108 with the WAVE1 complex.

    Alternative splice isoforms for TMEM108 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM108 Gene

Post-translational modifications for TMEM108 Gene

No data available for DME Specific Peptides for TMEM108 Gene

Domains & Families for TMEM108 Gene

Protein Domains for TMEM108 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM108 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM108: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM108 Gene

Function for TMEM108 Gene

Molecular function for TMEM108 Gene

UniProtKB/Swiss-Prot Function:
Transmembrane protein required for proper cognitive functions. Involved in the development of dentate gyrus (DG) neuron circuitry, is neccessary for AMPA receptors surface expression and proper excitatory postsynaptic currents of DG granule neurons. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Through the interaction with DST, mediates the docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport. In hippocampal neurons, required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 and recruits the WAVE1 complex to facilitate actin-dependent BDNF:NTRK2 early endocytic trafficking and mediate signaling from early endosomes.

Gene Ontology (GO) - Molecular Function for TMEM108 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM108: view
genes like me logo Genes that share phenotypes with TMEM108: view

Animal Models for TMEM108 Gene

MGI Knock Outs for TMEM108:

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM108

CRISPR Products

miRNA for TMEM108 Gene

miRTarBase miRNAs that target TMEM108

Inhibitory RNA Products

Cell Line Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM108 Gene

Localization for TMEM108 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM108 Gene

Membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Endosome membrane. Cell projection, axon. Cell projection, dendrite. Early endosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM108 gene
Compartment Confidence
endosome 4
plasma membrane 3
extracellular 2
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TMEM108 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005769 early endosome ISS --
GO:0010008 endosome membrane ISS --
GO:0014069 postsynaptic density ISS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TMEM108: view

Pathways & Interactions for TMEM108 Gene

SuperPathways for TMEM108 Gene

No Data Available

Interacting Proteins for TMEM108 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000324651%0d%0a9606.ENSP00000263388%0d%0a
Selected Interacting proteins: Q6UXF1-TM108_HUMAN ENSP00000324651 for TMEM108 Gene via MINT STRING IID

Gene Ontology (GO) - Biological Process for TMEM108 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis ISS --
GO:0008090 retrograde axonal transport ISS --
GO:0008150 biological_process ND --
GO:0021542 dentate gyrus development ISS --
GO:0031175 neuron projection development ISS --
genes like me logo Genes that share ontologies with TMEM108: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM108 Gene

Drugs & Compounds for TMEM108 Gene

No Compound Related Data Available

Transcripts for TMEM108 Gene

Unigene Clusters for TMEM108 Gene

Transmembrane protein 108:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM108 Gene

No ASD Table

Relevant External Links for TMEM108 Gene

GeneLoc Exon Structure for
TMEM108
ECgene alternative splicing isoforms for
TMEM108

Expression for TMEM108 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM108 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM108 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMEM108 Gene



Protein tissue co-expression partners for TMEM108 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM108 Gene:

TMEM108

SOURCE GeneReport for Unigene cluster for TMEM108 Gene:

Hs.191616

Evidence on tissue expression from TISSUES for TMEM108 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with TMEM108: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM108 Gene

Orthologs for TMEM108 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM108 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM108 34 35
  • 99.61 (n)
dog
(Canis familiaris)
Mammalia TMEM108 34 35
  • 87.4 (n)
cow
(Bos Taurus)
Mammalia LOC511034 34
  • 85.66 (n)
TMEM108 35
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem108 34
  • 81.47 (n)
mouse
(Mus musculus)
Mammalia Tmem108 34 16 35
  • 81.24 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM108 35
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM108 34 35
  • 63.04 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM108 35
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem108 34
  • 62.03 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem108 35
  • 26 (a)
OneToOne
Dr.10185 34
Species where no ortholog for TMEM108 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM108 Gene

ENSEMBL:
Gene Tree for TMEM108 (if available)
TreeFam:
Gene Tree for TMEM108 (if available)

Paralogs for TMEM108 Gene

No data available for Paralogs for TMEM108 Gene

Variants for TMEM108 Gene

Sequence variations from dbSNP and Humsavar for TMEM108 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000018591 -- 133,178,063(+) TCACA(A/G)TTGCT intron-variant
rs1000032053 -- 133,146,693(+) CTTGG(A/G)ATGGT intron-variant
rs1000051906 -- 133,339,237(+) TAAAG(A/G)CAAAA intron-variant
rs1000069744 -- 133,045,929(+) CCAAC(A/T)TGCAG utr-variant-5-prime
rs1000070370 -- 133,089,514(+) GACTC(-/AT)GTGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM108 Gene

Variant ID Type Subtype PubMed ID
dgv2603n106 CNV deletion 24896259
dgv4902n100 CNV loss 25217958
esv2635909 CNV insertion 19546169
esv2659873 CNV deletion 23128226
esv2669013 CNV deletion 23128226
esv2725936 CNV deletion 23290073
esv2725937 CNV deletion 23290073
esv2759179 CNV loss 17122850
esv2760760 CNV loss 21179565
esv28544 CNV loss 19812545
esv32760 CNV loss 17666407
esv3360224 CNV duplication 20981092
esv3562566 CNV deletion 23714750
esv3597838 CNV loss 21293372
esv3597840 CNV loss 21293372
esv3597841 CNV loss 21293372
esv9637 CNV gain 19470904
nsv1014344 CNV loss 25217958
nsv1118704 CNV duplication 24896259
nsv1139161 CNV deletion 24896259
nsv4016 CNV deletion 18451855
nsv460857 CNV loss 19166990
nsv514168 CNV gain+loss 21397061
nsv591799 CNV gain 21841781
nsv591801 CNV loss 21841781

Variation tolerance for TMEM108 Gene

Residual Variation Intolerance Score: 38.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.97; 49.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM108 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM108

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM108 Gene

Disorders for TMEM108 Gene

Relevant External Links for TMEM108

Genetic Association Database (GAD)
TMEM108
Human Genome Epidemiology (HuGE) Navigator
TMEM108
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM108

No disorders were found for TMEM108 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM108 Gene

Publications for TMEM108 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. (PMID: 21102462) Elks C.E. … Murray A. (Nat. Genet. 2010) 3 46 64
  4. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PMID: 18519826) Uhl G.R. … Lerman C. (Arch. Gen. Psychiatry 2008) 3 46 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for TMEM108 Gene

Sources for TMEM108 Gene

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