Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMEM108 Gene

Aliases for TMEM108 Gene

  • Transmembrane Protein 108 2 3
  • Cancer/Testis Antigen 124 2 3
  • KIAA1690 4
  • CT124 3

External Ids for TMEM108 Gene

Previous GeneCards Identifiers for TMEM108 Gene

  • GC03P134240
  • GC03P132757
  • GC03P130137

Summaries for TMEM108 Gene

GeneCards Summary for TMEM108 Gene

TMEM108 (Transmembrane Protein 108) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM108 Gene

Genomics for TMEM108 Gene

Regulatory Elements for TMEM108 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMEM108 Gene

Start:
133,038,288 bp from pter
End:
133,397,792 bp from pter
Size:
359,505 bases
Orientation:
Plus strand

Genomic View for TMEM108 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM108 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM108 Gene

Proteins for TMEM108 Gene

  • Protein details for TMEM108 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXF1-TM108_HUMAN
    Recommended name:
    Transmembrane protein 108
    Protein Accession:
    Q6UXF1
    Secondary Accessions:
    • D3DNC9
    • Q9BQH1
    • Q9BW81
    • Q9C0H3

    Protein attributes for TMEM108 Gene

    Size:
    575 amino acids
    Molecular mass:
    59948 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM108 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM108 Gene

Proteomics data for TMEM108 Gene at MOPED

Post-translational modifications for TMEM108 Gene

  • Glycosylation at Asn178, Asn223, Asn261, and Asn446
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM108 Gene

Domains for TMEM108 Gene

Protein Domains for TMEM108 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TMEM108 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM108: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM108 Gene

Function for TMEM108 Gene

Gene Ontology (GO) - Molecular Function for TMEM108 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM108: view

Animal Model Products

CRISPR Products

miRNA for TMEM108 Gene

miRTarBase miRNAs that target TMEM108

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM108

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM108 Gene

Localization for TMEM108 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM108 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM108 Gene COMPARTMENTS Subcellular localization image for TMEM108 gene
Compartment Confidence
extracellular 2
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for TMEM108 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM108: view

Pathways for TMEM108 Gene

SuperPathways for TMEM108 Gene

No Data Available

Interacting Proteins for TMEM108 Gene

Gene Ontology (GO) - Biological Process for TMEM108 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM108: view

No data available for Pathways by source for TMEM108 Gene

Transcripts for TMEM108 Gene

Unigene Clusters for TMEM108 Gene

Transmembrane protein 108:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM108

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM108 Gene

No ASD Table

Relevant External Links for TMEM108 Gene

GeneLoc Exon Structure for
TMEM108
ECgene alternative splicing isoforms for
TMEM108

Expression for TMEM108 Gene

mRNA expression in normal human tissues for TMEM108 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for TMEM108 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TMEM108 Gene

SOURCE GeneReport for Unigene cluster for TMEM108 Gene Hs.191616

genes like me logo Genes that share expressions with TMEM108: view

Expression partners for TMEM108 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM108 Gene

Orthologs for TMEM108 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM108 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC511034 35
  • 85.66 (n)
  • 82.4 (a)
TMEM108 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM108 35
  • 87.4 (n)
  • 82.93 (a)
TMEM108 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem108 35
  • 81.24 (n)
  • 75.78 (a)
Tmem108 16
Tmem108 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM108 35
  • 99.61 (n)
  • 99.29 (a)
TMEM108 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem108 35
  • 81.47 (n)
  • 76.88 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM108 36
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM108 35
  • 63.04 (n)
  • 60.6 (a)
TMEM108 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM108 36
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem108 35
  • 62.03 (n)
  • 62.55 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.10185 35
tmem108 36
  • 26 (a)
OneToOne
Species with no ortholog for TMEM108:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM108 Gene

ENSEMBL:
Gene Tree for TMEM108 (if available)
TreeFam:
Gene Tree for TMEM108 (if available)

Paralogs for TMEM108 Gene

No data available for Paralogs for TMEM108 Gene

Variants for TMEM108 Gene

Sequence variations from dbSNP and Humsavar for TMEM108 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs2331 -- 133,041,375(+) CCCCA(A/G)GGCTC intron-variant
rs713441 -- 133,270,059(-) GATGC(C/T)TATTA intron-variant
rs766034 -- 133,101,567(+) TCTGG(A/G)CTTCA intron-variant
rs766952 -- 133,262,557(-) AGCAG(C/T)GAAGA intron-variant
rs769097 -- 133,262,969(+) GGGAA(A/C)CTGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM108 Gene

Variant ID Type Subtype PubMed ID
esv32760 CNV Loss 17666407
esv2669013 CNV Deletion 23128226
esv2635909 CNV Insertion 19546169
esv9637 CNV Gain 19470904
nsv4016 CNV Loss 18451855
esv28544 CNV Loss 19812545
esv2659873 CNV Deletion 23128226
nsv514168 CNV Complex 21397061
esv2725936 CNV Deletion 23290073
esv2725937 CNV Deletion 23290073
dgv1510e1 CNV Complex 17122850
nsv877503 CNV Gain 21882294
nsv460857 CNV Loss 19166990

Relevant External Links for TMEM108 Gene

HapMap Linkage Disequilibrium report
TMEM108

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM108 Gene

Disorders for TMEM108 Gene

Relevant External Links for TMEM108

Genetic Association Database (GAD)
TMEM108
Human Genome Epidemiology (HuGE) Navigator
TMEM108

No disorders were found for TMEM108 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for TMEM108 Gene

Publications for TMEM108 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PMID: 18519826) Uhl G.R. … Lerman C. (Arch. Gen. Psychiatry 2008) 3 48

Products for TMEM108 Gene

Sources for TMEM108 Gene

Back to Top

Content