Aliases for TMEM108 Gene
External Ids for TMEM108 Gene
Previous GeneCards Identifiers for TMEM108 Gene
GeneCards Summary for TMEM108 Gene
TMEM108 (Transmembrane Protein 108) is a Protein Coding gene.
UniProtKB/Swiss-Prot for TMEM108 Gene
Transmembrane protein required for proper cognitive functions. Involved in the development of dentate gyrus (DG) neuron circuitry, is neccessary for AMPA receptors surface expression and proper excitatory postsynaptic currents of DG granule neurons. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Through the interaction with DST, mediates the docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport. In hippocampal neurons, required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 and recruits the WAVE1 complex to facilitate actin-dependent BDNF:NTRK2 early endocytic trafficking and mediate signaling from early endosomes.