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Aliases for TMEM108 Gene

Aliases for TMEM108 Gene

  • Transmembrane Protein 108 2 3 5
  • Cancer/Testis Antigen 124 2 3
  • KIAA1690 4
  • CT124 3

External Ids for TMEM108 Gene

Previous GeneCards Identifiers for TMEM108 Gene

  • GC03P134240
  • GC03P132757
  • GC03P130137

Summaries for TMEM108 Gene

GeneCards Summary for TMEM108 Gene

TMEM108 (Transmembrane Protein 108) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM108 Gene

Genomics for TMEM108 Gene

Regulatory Elements for TMEM108 Gene

Enhancers for TMEM108 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMEM108 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM108 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM108 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM108 Gene

Chromosome:
3
Start:
133,038,288 bp from pter
End:
133,397,792 bp from pter
Size:
359,505 bases
Orientation:
Plus strand

Genomic View for TMEM108 Gene

Genes around TMEM108 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM108 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM108 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM108 Gene

Proteins for TMEM108 Gene

  • Protein details for TMEM108 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXF1-TM108_HUMAN
    Recommended name:
    Transmembrane protein 108
    Protein Accession:
    Q6UXF1
    Secondary Accessions:
    • D3DNC9
    • Q9BQH1
    • Q9BW81
    • Q9C0H3

    Protein attributes for TMEM108 Gene

    Size:
    575 amino acids
    Molecular mass:
    59948 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM108 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM108 Gene

Proteomics data for TMEM108 Gene at MOPED

Post-translational modifications for TMEM108 Gene

  • Glycosylation at Asn 178, Asn 223, Asn 261, and Asn 446
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM108 Gene

Domains & Families for TMEM108 Gene

Protein Domains for TMEM108 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM108 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM108: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM108 Gene

Function for TMEM108 Gene

genes like me logo Genes that share phenotypes with TMEM108: view

Animal Models for TMEM108 Gene

MGI Knock Outs for TMEM108:

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM108

CRISPR Products

miRNA for TMEM108 Gene

miRTarBase miRNAs that target TMEM108

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM108 Gene

Localization for TMEM108 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM108 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM108 Gene COMPARTMENTS Subcellular localization image for TMEM108 gene
Compartment Confidence
extracellular 2
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for TMEM108 Gene

Pathways & Interactions for TMEM108 Gene

SuperPathways for TMEM108 Gene

No Data Available

Interacting Proteins for TMEM108 Gene

Gene Ontology (GO) - Biological Process for TMEM108 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM108 Gene

Drugs & Compounds for TMEM108 Gene

No Compound Related Data Available

Transcripts for TMEM108 Gene

Unigene Clusters for TMEM108 Gene

Transmembrane protein 108:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM108 Gene

No ASD Table

Relevant External Links for TMEM108 Gene

GeneLoc Exon Structure for
TMEM108
ECgene alternative splicing isoforms for
TMEM108

Expression for TMEM108 Gene

mRNA expression in normal human tissues for TMEM108 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM108 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMEM108 Gene



SOURCE GeneReport for Unigene cluster for TMEM108 Gene Hs.191616

genes like me logo Genes that share expression patterns with TMEM108: view

Protein tissue co-expression partners for TMEM108 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM108 Gene

Orthologs for TMEM108 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM108 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC511034 35
  • 85.66 (n)
  • 82.4 (a)
TMEM108 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM108 35
  • 87.4 (n)
  • 82.93 (a)
TMEM108 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem108 35
  • 81.24 (n)
  • 75.78 (a)
Tmem108 16
Tmem108 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM108 35
  • 99.61 (n)
  • 99.29 (a)
TMEM108 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem108 35
  • 81.47 (n)
  • 76.88 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM108 36
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM108 35
  • 63.04 (n)
  • 60.6 (a)
TMEM108 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM108 36
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem108 35
  • 62.03 (n)
  • 62.55 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.10185 35
tmem108 36
  • 26 (a)
OneToOne
Species with no ortholog for TMEM108:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM108 Gene

ENSEMBL:
Gene Tree for TMEM108 (if available)
TreeFam:
Gene Tree for TMEM108 (if available)

Paralogs for TMEM108 Gene

No data available for Paralogs for TMEM108 Gene

Variants for TMEM108 Gene

Sequence variations from dbSNP and Humsavar for TMEM108 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_051427 -
rs2331 -- 133,041,375(+) CCCCA(A/G)GGCTC intron-variant
rs713441 -- 133,270,059(-) GATGC(C/T)TATTA intron-variant
rs766034 -- 133,101,567(+) TCTGG(A/G)CTTCA intron-variant
rs766952 -- 133,262,557(-) AGCAG(C/T)GAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM108 Gene

Variant ID Type Subtype PubMed ID
esv32760 CNV Loss 17666407
esv2669013 CNV Deletion 23128226
esv2635909 CNV Insertion 19546169
esv9637 CNV Gain 19470904
nsv4016 CNV Loss 18451855
esv28544 CNV Loss 19812545
esv2659873 CNV Deletion 23128226
nsv514168 CNV Complex 21397061
esv2725936 CNV Deletion 23290073
esv2725937 CNV Deletion 23290073
dgv1510e1 CNV Complex 17122850
nsv877503 CNV Gain 21882294
nsv460857 CNV Loss 19166990

Variation tolerance for TMEM108 Gene

Residual Variation Intolerance Score: 38.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.97; 49.50% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TMEM108 Gene

Disorders for TMEM108 Gene

Relevant External Links for TMEM108

Genetic Association Database (GAD)
TMEM108
Human Genome Epidemiology (HuGE) Navigator
TMEM108
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM108

No disorders were found for TMEM108 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM108 Gene

Publications for TMEM108 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 67
  2. Notch3 interactome analysis identified WWP2 as a negative regulator of Notch3 signaling in ovarian cancer. (PMID: 25356737) Jung J.G. … Wang T.L. (PLoS Genet. 2014) 3
  3. A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications. (PMID: 21529783) Heath A.C. … Montgomery G.W. (Biol. Psychiatry 2011) 3
  4. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3
  5. A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order. (PMID: 22036096) Ramasamy A. … Jarvis D.L. (J. Allergy Clin. Immunol. 2011) 3

Products for TMEM108 Gene

Sources for TMEM108 Gene

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