TMEM107 Gene
protein-coding GIFtS: 38
GCID: GC17M008085
|
|
transmembrane protein 107
| |
Aliases
for TMEM107 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protein 1071 2 | | MGC107441 | | GRVS6382 | | PRO12682 |
Export aliases for TMEM107 gene to outside databasesPrevious GC identifers: GC17M008027 GC17M008028 GC17M008077 GC17M008080 GC17M008082 |
Summaries
for TMEM107 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TM107_HUMAN, Q6UX40Function: Plays a role in cilia formation and embryonic patterning. Requires for normal Sonic hedgehog (Shh) signalingin the neural tube and acts in combination with GLI2 and GLI3 to pattern ventral and intermediate neuronal cell types(By similarity)
|
Genomic Views
for TMEM107 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010718.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMEM107 gene promoter:
Pbx1a AP-1 NF-YC MIF-1 CUTL1 Nkx2-5 CBF-A Zic3 CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM107
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM107 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p13.1 Ensembl cytogenetic band: 17p13.1 HGNC cytogenetic band: 17p13.1TMEM107 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M008085: view genomic region
(about GC identifiers)
Start:
|
8,076,296 bp from pter |
End:
|
8,079,717 bp from pter |
Size:
|
3,422 bases |
Orientation:
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minus strand |
|
Proteins
for TMEM107 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TM107_HUMAN, Q6UX40 (See
protein sequence)Recommended Name: Transmembrane protein 107 Size: 140 amino acids; 15503 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=AAK38512.1; Type=Frameshift; Positions=63, 82;
Secondary accessions: A0PJV7 Q6NSE3 Q6ZRX9 Q96T82Alternative splicing: 4 isoforms: Q6UX40-1 Q6UX40-2 Q6UX40-3 Q6UX40-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TMEM107: NX_Q6UX40
TMEM107 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_115730.2 NP_898888.1
ENSEMBL proteins: ENSP00000404753 ENSP00000433148 ENSP00000402732 ENSP00000436674 ENSP00000314116 ENSP00000389420
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- | | GO:0016021 | integral to membrane |
IEA | -- |
TMEM107 for ontologies About GeneDecksing
TMEM107 Antibody Products:
Assay Products for TMEM107: |
Protein
Domains /
Families
for TMEM107 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q6UX40 |
Function
for TMEM107 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TM107_HUMAN, Q6UX40Function: Plays a role in cilia formation and embryonic patterning. Requires for normal Sonic hedgehog (Shh) signalingin the neural tube and acts in combination with GLI2 and GLI3 to pattern ventral and intermediate neuronal cell types(By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM107 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM107 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector (see all 2): TMEM107 (NM_032354) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM107 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM107 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM107 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
TMEM107 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for TMEM107:
Animal Models:
Mouse knock-out Tmem107tm1Lex for TMEM107
12 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Tmem107):
TMEM107 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TMEM107 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM107
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
TMEM107 for ontologies About GeneDecksing
|
Drugs & Compounds
for TMEM107 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM107
Search CenterWatch for drugs/clinical trials and news about TMEM107 / TM107
|
Transcripts
for TMEM107 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMEM107 gene (2 alternative transcripts): NM_032354.3 NM_183065.2 Unigene Cluster for TMEM107: Transmembrane protein 107 Hs.513933 [show with all ESTs]Unigene Representative Sequence: AK1278919 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000449985(uc002gkg.4 uc002gkh.4 uc002gki.4 uc002gkj.4)
ENST00000532998(uc002gkk.2) ENST00000437139 ENST00000533070 ENST00000316425
ENST00000431792 ENST00000526920 ENST00000529756 ENST00000417073
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM107 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM107 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): TMEM107 (NM_032354) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM107 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM107 |
Additional cDNA sequence: AF311338.1 AK127891.1 AK315666.1 AY358525.1 BC006292.2 BC070231.1 BC119730.1 BC119731.1 BC127649.1 BC127650.1 9 DOTS entries: DT.100729103 DT.424880 DT.86847997 DT.100787695 DT.307661 DT.95111194 DT.100022875 DT.100787698 DT.92037719 24/88 AceView cDNA sequences (see all 88): BC006292 AW015797 BF438621 AI742969 NM_183065 AY358525 BM706646 NM_032354 AI796088 AA364444 BX387529 BF971873 BU852346 BQ022554 BE049359 AA922142 BQ448612 BM968140 BX387527 BX115291 BI763924 BM906606 AA210958 BM768665
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM107 (see all 8) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | - | | | | | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TMEM107
|
Expression
for TMEM107 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM107 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAACGTGATT
About this image
See TMEM107 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM107
SOURCE GeneReport for Unigene cluster: Hs.513933
SABiosciences Custom PCR Arrays for TMEM107
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM107
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM107 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM107 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM107 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM107 |
Orthologs
for TMEM107 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TMEM107 gene from 4/14 species (see all 14) About this table
ENSEMBL Gene Tree for TMEM107 (if available)
TreeFam Gene Tree for TMEM107 (if available) |
Paralogs
for TMEM107 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TMEM107 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM107 (8076296 - 8079717 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TMEM107
1 CNV: 4988 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM107 |
|
Disorders
/ Diseases
for TMEM107 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for TMEM107 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM107 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM107) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Gene expression in the mouse eye: an online resource for genetics using 103 strains of mice. (PubMed id 19727342)1 Geisert E.E....Williams R.W. (2009)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for TMEM107 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMEM107 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMEM107 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM107 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM107 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMEM107 gene:
Search GeneIP for patents involving TMEM107
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM107 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TMEM107 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM107 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM107 | | | OriGene Protein Over-expression Lysate for TMEM107 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMEM107 | | OriGene 3'-UTR Clone for TMEM107 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM107 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM107 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TMEM107 | | OriGene Custom Protein Services for TMEM107 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM107 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM107 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM107 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM107 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM107 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM107 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for TMEM107 |
| |  |  |  |  | | | | |
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 | | | TMEM107 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM107 |
|  |  |  | | | | Search ThermoFisher Antibodies for TMEM107 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM107 |
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