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Aliases for TMEM107 Gene

Aliases for TMEM107 Gene

  • Transmembrane Protein 107 2 3
  • GRVS638 3
  • PRO1268 3

External Ids for TMEM107 Gene

Previous GeneCards Identifiers for TMEM107 Gene

  • GC17M008027
  • GC17M008028
  • GC17M008077
  • GC17M008080
  • GC17M008082
  • GC17M008085
  • GC17M008113
  • GC17M008187

Summaries for TMEM107 Gene

GeneCards Summary for TMEM107 Gene

TMEM107 (Transmembrane Protein 107) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM107 Gene

  • Plays a role in cilia formation and embryonic patterning. Requires for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with GLI2 and GLI3 to pattern ventral and intermediate neuronal cell types (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM107 Gene

Genomics for TMEM107 Gene

Regulatory Elements for TMEM107 Gene

Genomic Location for TMEM107 Gene

Start:
8,172,978 bp from pter
End:
8,176,399 bp from pter
Size:
3,422 bases
Orientation:
Minus strand

Genomic View for TMEM107 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM107 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM107 Gene

Proteins for TMEM107 Gene

  • Protein details for TMEM107 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UX40-TM107_HUMAN
    Recommended name:
    Transmembrane protein 107
    Protein Accession:
    Q6UX40
    Secondary Accessions:
    • A0PJV7
    • Q6NSE3
    • Q6ZRX9
    • Q96T82

    Protein attributes for TMEM107 Gene

    Size:
    140 amino acids
    Molecular mass:
    15503 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK38512.1; Type=Frameshift; Positions=63, 82; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM107 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM107 Gene

Proteomics data for TMEM107 Gene at MOPED

Post-translational modifications for TMEM107 Gene

Other Protein References for TMEM107 Gene

No data available for DME Specific Peptides for TMEM107 Gene

Domains for TMEM107 Gene

Protein Domains for TMEM107 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM107 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM107: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM107 Gene

Function for TMEM107 Gene

Molecular function for TMEM107 Gene

UniProtKB/Swiss-Prot Function: Plays a role in cilia formation and embryonic patterning. Requires for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with GLI2 and GLI3 to pattern ventral and intermediate neuronal cell types (By similarity).

Gene Ontology (GO) - Molecular Function for TMEM107 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM107: view
genes like me logo Genes that share phenotypes with TMEM107: view

Animal Models for TMEM107 Gene

MGI Knock Outs for TMEM107:

miRNA for TMEM107 Gene

miRTarBase miRNAs that target TMEM107

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TMEM107 Gene

Localization for TMEM107 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM107 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for TMEM107 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM107: view

No data available for Subcellular locations from COMPARTMENTS for TMEM107 Gene

Pathways for TMEM107 Gene

SuperPathways for TMEM107 Gene

No Data Available

Interacting Proteins for TMEM107 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000314116%0d%0a9606.ENSP00000328182%0d%0a
Selected Interacting proteins: ENSP00000314116 for TMEM107 Gene via STRING

Symbol External ID(s) Details
CLN8

Gene Ontology (GO) - Biological Process for TMEM107 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0021532 neural tube patterning IEA --
GO:0042384 cilium assembly ISS --
GO:0042733 embryonic digit morphogenesis IEA --
genes like me logo Genes that share ontologies with TMEM107: view

No data available for Pathways by source for TMEM107 Gene

Transcripts for TMEM107 Gene

Unigene Clusters for TMEM107 Gene

Transmembrane protein 107:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM107 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d · 5e
SP1: -
SP2: - -
SP3: - -
SP4: - - -
SP5: -
SP6: -
SP7: -
SP8: - - - - - - -

Relevant External Links for TMEM107 Gene

GeneLoc Exon Structure for
TMEM107
ECgene alternative splicing isoforms for
TMEM107

Expression for TMEM107 Gene

mRNA expression in normal human tissues for TMEM107 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TMEM107 Gene

SOURCE GeneReport for Unigene cluster for TMEM107 Gene Hs.513933

genes like me logo Genes that share expressions with TMEM107: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM107 Gene

Orthologs for TMEM107 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM107 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM107 35
  • 100 (n)
  • 100 (a)
TMEM107 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM107 35
  • 92.14 (n)
  • 91.43 (a)
TMEM107 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM107 35
  • 90.87 (n)
  • 94.52 (a)
TMEM107 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem107 35
  • 87.14 (n)
  • 88.57 (a)
Tmem107 16
Tmem107 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM107 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem107 35
  • 86.67 (n)
  • 88.57 (a)
lizard
(Anolis carolinensis)
Reptilia TMEM107 36
  • 68 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.34137 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101731170 35
  • 66.67 (n)
  • 67.63 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10133 35
zebrafish
(Danio rerio)
Actinopterygii tmem107l 35
  • 62.83 (n)
  • 63.31 (a)
tmem107l 36
  • 59 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
OneToOne
Species with no ortholog for TMEM107:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM107 Gene

ENSEMBL:
Gene Tree for TMEM107 (if available)
TreeFam:
Gene Tree for TMEM107 (if available)

Paralogs for TMEM107 Gene

No data available for Paralogs for TMEM107 Gene

Variants for TMEM107 Gene

Sequence variations from dbSNP and Humsavar for TMEM107 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs6503090 -- 8,177,091(+) GAAAG(A/G)GTGGG upstream-variant-2KB
rs7223859 -- 8,177,535(+) GATAA(C/T)AGGCG upstream-variant-2KB
rs8064449 -- 8,175,711(+) GTCCT(C/G)ATAGA intron-variant
rs9893474 -- 8,172,876(+) AAAAA(A/C)CAAAA downstream-variant-500B
rs9893475 -- 8,172,877(+) AAAAC(A/C)AAAAG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TMEM107 Gene

Variant ID Type Subtype PubMed ID
nsv833352 CNV Loss 17160897
nsv907658 CNV Loss 21882294
nsv1964 CNV Insertion 18451855
nsv527475 CNV Loss 19592680
nsv833353 CNV Loss 17160897
dgv3056n71 CNV Loss 21882294
nsv827879 CNV Gain 20364138

Relevant External Links for TMEM107 Gene

HapMap Linkage Disequilibrium report
TMEM107
Human Gene Mutation Database (HGMD)
TMEM107

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM107 Gene

Disorders for TMEM107 Gene

No disorders were found for TMEM107 Gene.

No data available for UniProtKB/Swiss-Prot for TMEM107 Gene

Publications for TMEM107 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for TMEM107 Gene

Sources for TMEM107 Gene

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