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Aliases for TMEM106C Gene

Aliases for TMEM106C Gene

  • Transmembrane Protein 106C 2 3 5
  • Endoplasmic Reticulum Membrane Protein Overexpressed In Cancer 4
  • EMOC 4

External Ids for TMEM106C Gene

Previous GeneCards Identifiers for TMEM106C Gene

  • GC12P046645
  • GC12P048357
  • GC12P045389

Summaries for TMEM106C Gene

GeneCards Summary for TMEM106C Gene

TMEM106C (Transmembrane Protein 106C) is a Protein Coding gene. An important paralog of this gene is TMEM106A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM106C Gene

Genomics for TMEM106C Gene

Regulatory Elements for TMEM106C Gene

Enhancers for TMEM106C Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMEM106C on UCSC Golden Path with GeneCards custom track

Promoters for TMEM106C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM106C on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM106C Gene

Chromosome:
12
Start:
47,963,547 bp from pter
End:
47,968,878 bp from pter
Size:
5,332 bases
Orientation:
Plus strand

Genomic View for TMEM106C Gene

Genes around TMEM106C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM106C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM106C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM106C Gene

Proteins for TMEM106C Gene

  • Protein details for TMEM106C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BVX2-T106C_HUMAN
    Recommended name:
    Transmembrane protein 106C
    Protein Accession:
    Q9BVX2
    Secondary Accessions:
    • B2R998
    • B7Z5M4
    • Q3B761

    Protein attributes for TMEM106C Gene

    Size:
    250 amino acids
    Molecular mass:
    27875 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM106C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM106C Gene

Proteomics data for TMEM106C Gene at MOPED

Post-translational modifications for TMEM106C Gene

  • Ubiquitination at Lys 17
  • Glycosylation at Asn 173 and Asn 186
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM106C Gene

Domains & Families for TMEM106C Gene

Protein Domains for TMEM106C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM106C Gene

Graphical View of Domain Structure for InterPro Entry

Q9BVX2

UniProtKB/Swiss-Prot:

T106C_HUMAN :
  • Belongs to the TMEM106 family.
Family:
  • Belongs to the TMEM106 family.
genes like me logo Genes that share domains with TMEM106C: view

No data available for Gene Families for TMEM106C Gene

Function for TMEM106C Gene

Phenotypes for TMEM106C Gene

GenomeRNAi human phenotypes for TMEM106C:
genes like me logo Genes that share phenotypes with TMEM106C: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM106C Gene

Localization for TMEM106C Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM106C Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM106C Gene COMPARTMENTS Subcellular localization image for TMEM106C gene
Compartment Confidence
endoplasmic reticulum 4
nucleus 2
plasma membrane 2
cytoskeleton 1
cytosol 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMEM106C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM106C: view

Pathways & Interactions for TMEM106C Gene

SuperPathways for TMEM106C Gene

No Data Available

Interacting Proteins for TMEM106C Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000400471%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000375478%0d%0a9606.ENSP00000307093%0d%0a
Selected Interacting proteins: ENSP00000400471 Q9BVX2-T106C_HUMAN for TMEM106C Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for TMEM106C Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM106C Gene

Drugs & Compounds for TMEM106C Gene

No Compound Related Data Available

Transcripts for TMEM106C Gene

Unigene Clusters for TMEM106C Gene

Transmembrane protein 106C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM106C Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c ·
SP1: - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - - - - - -
SP6: - - - - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - - - - -
SP9: - - - - - - - - - - -
SP10: - - - - - - - - - -
SP11: - - - -
SP12: - - -
SP13: - - -
SP14: - - - - - - - - - - - -
SP15: -

ExUns: 10d · 10e · 10f · 10g · 10h · 10i · 10j
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for TMEM106C Gene

GeneLoc Exon Structure for
TMEM106C
ECgene alternative splicing isoforms for
TMEM106C

Expression for TMEM106C Gene

mRNA expression in normal human tissues for TMEM106C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM106C Gene

This gene is overexpressed in Cerebrospinal fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM106C Gene



SOURCE GeneReport for Unigene cluster for TMEM106C Gene Hs.596726

genes like me logo Genes that share expression patterns with TMEM106C: view

Protein tissue co-expression partners for TMEM106C Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM106C Gene

Orthologs for TMEM106C Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM106C Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM106C 35
  • 84.41 (n)
  • 85.48 (a)
TMEM106C 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM106C 35
  • 91.3 (n)
  • 91.57 (a)
TMEM106C 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem106c 35
  • 82.05 (n)
  • 79.76 (a)
Tmem106c 16
Tmem106c 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM106C 35
  • 99.87 (n)
  • 99.6 (a)
TMEM106C 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem106c 35
  • 81.32 (n)
  • 77.82 (a)
chicken
(Gallus gallus)
Aves TMEM106C 35
  • 71.58 (n)
  • 74.59 (a)
TMEM106C 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM106C 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem106c 35
  • 64.92 (n)
  • 63.71 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC53571 35
zebrafish
(Danio rerio)
Actinopterygii zgc:153351 35
  • 63.06 (n)
  • 58.01 (a)
TMEM106C (1 of 2) 36
  • 49 (a)
OneToMany
TMEM106C (2 of 2) 36
  • 50 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToMany
Species with no ortholog for TMEM106C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM106C Gene

ENSEMBL:
Gene Tree for TMEM106C (if available)
TreeFam:
Gene Tree for TMEM106C (if available)

Paralogs for TMEM106C Gene

Paralogs for TMEM106C Gene

genes like me logo Genes that share paralogs with TMEM106C: view

Variants for TMEM106C Gene

Sequence variations from dbSNP and Humsavar for TMEM106C Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs2286025 - 47,966,201(-) TAAGG(A/G)AGACG intron-variant, reference, missense
rs35000511 - 47,965,893(+) TGGTG(C/G/T)TTTTC reference, missense
rs2079296 -- 47,968,021(-) CCCCA(G/T)GCACA intron-variant
rs6823 -- 47,968,629(+) GAAGT(C/G)GCAGC utr-variant-3-prime
rs12814542 -- 47,963,315(+) TAGCC(G/T)GCAGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM106C Gene

Variant ID Type Subtype PubMed ID
nsv832401 CNV Loss 17160897
nsv519174 CNV Loss 19592680
nsv899061 CNV Loss 21882294

Variation tolerance for TMEM106C Gene

Residual Variation Intolerance Score: 67.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.61; 86.21% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TMEM106C Gene

Disorders for TMEM106C Gene

Relevant External Links for TMEM106C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM106C

No disorders were found for TMEM106C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM106C Gene

Publications for TMEM106C Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3

Products for TMEM106C Gene

Sources for TMEM106C Gene

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