Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMEM106C Gene

Aliases for TMEM106C Gene

  • Transmembrane Protein 106C 2 3
  • Endoplasmic Reticulum Membrane Protein Overexpressed In Cancer 4
  • EMOC 4

External Ids for TMEM106C Gene

Previous GeneCards Identifiers for TMEM106C Gene

  • GC12P046645
  • GC12P048357
  • GC12P045389

Summaries for TMEM106C Gene

GeneCards Summary for TMEM106C Gene

TMEM106C (Transmembrane Protein 106C) is a Protein Coding gene. An important paralog of this gene is TMEM106B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM106C Gene

Genomics for TMEM106C Gene

Regulatory Elements for TMEM106C Gene

Genomic Location for TMEM106C Gene

Start:
47,963,547 bp from pter
End:
47,968,878 bp from pter
Size:
5,332 bases
Orientation:
Plus strand

Genomic View for TMEM106C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM106C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM106C Gene

Proteins for TMEM106C Gene

  • Protein details for TMEM106C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BVX2-T106C_HUMAN
    Recommended name:
    Transmembrane protein 106C
    Protein Accession:
    Q9BVX2
    Secondary Accessions:
    • B2R998
    • B7Z5M4
    • Q3B761

    Protein attributes for TMEM106C Gene

    Size:
    250 amino acids
    Molecular mass:
    27875 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM106C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM106C Gene

Proteomics data for TMEM106C Gene at MOPED

Post-translational modifications for TMEM106C Gene

  • Ubiquitination at Lys17
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM106C Gene

Domains for TMEM106C Gene

Protein Domains for TMEM106C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM106C Gene

Graphical View of Domain Structure for InterPro Entry

Q9BVX2

UniProtKB/Swiss-Prot:

T106C_HUMAN :
  • Q9BVX2
Family:
  • Belongs to the TMEM106 family.
genes like me logo Genes that share domains with TMEM106C: view

No data available for Gene Families for TMEM106C Gene

Function for TMEM106C Gene

Gene Ontology (GO) - Molecular Function for TMEM106C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TMEM106C: view

Phenotypes for TMEM106C Gene

GenomeRNAi human phenotypes for TMEM106C:
genes like me logo Genes that share phenotypes with TMEM106C: view

Animal Model Products

CRISPR Products

miRNA for TMEM106C Gene

miRTarBase miRNAs that target TMEM106C

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM106C Gene

Localization for TMEM106C Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM106C Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM106C Gene COMPARTMENTS Subcellular localization image for TMEM106C gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 2
plasma membrane 2
cytoskeleton 1
cytosol 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMEM106C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM106C: view

Pathways for TMEM106C Gene

SuperPathways for TMEM106C Gene

No Data Available

Interacting Proteins for TMEM106C Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000400471%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000375478%0d%0a9606.ENSP00000307093%0d%0a
Selected Interacting proteins: ENSP00000400471 Q9BVX2-T106C_HUMAN for TMEM106C Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for TMEM106C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM106C: view

No data available for Pathways by source for TMEM106C Gene

Transcripts for TMEM106C Gene

Unigene Clusters for TMEM106C Gene

Transmembrane protein 106C:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM106C

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM106C Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c ·
SP1: - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - - - - - -
SP6: - - - - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - - - - -
SP9: - - - - - - - - - - -
SP10: - - - - - - - - - -
SP11: - - - -
SP12: - - -
SP13: - - -
SP14: - - - - - - - - - - - -
SP15: -

ExUns: 10d · 10e · 10f · 10g · 10h · 10i · 10j
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for TMEM106C Gene

GeneLoc Exon Structure for
TMEM106C
ECgene alternative splicing isoforms for
TMEM106C

Expression for TMEM106C Gene

mRNA expression in normal human tissues for TMEM106C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM106C Gene

SOURCE GeneReport for Unigene cluster for TMEM106C Gene Hs.596726

genes like me logo Genes that share expressions with TMEM106C: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM106C Gene

Orthologs for TMEM106C Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM106C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM106C 35
  • 99.87 (n)
  • 99.6 (a)
TMEM106C 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM106C 35
  • 84.41 (n)
  • 85.48 (a)
TMEM106C 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM106C 35
  • 91.3 (n)
  • 91.57 (a)
TMEM106C 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem106c 35
  • 82.05 (n)
  • 79.76 (a)
Tmem106c 16
Tmem106c 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem106c 35
  • 81.32 (n)
  • 77.82 (a)
chicken
(Gallus gallus)
Aves TMEM106C 35
  • 71.58 (n)
  • 74.59 (a)
TMEM106C 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM106C 36
  • 62 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC53571 35
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem106c 35
  • 64.92 (n)
  • 63.71 (a)
zebrafish
(Danio rerio)
Actinopterygii TMEM106C (1 of 2) 36
  • 49 (a)
OneToMany
TMEM106C (2 of 2) 36
  • 50 (a)
OneToMany
zgc:153351 35
  • 63.06 (n)
  • 58.01 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToMany
Species with no ortholog for TMEM106C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM106C Gene

ENSEMBL:
Gene Tree for TMEM106C (if available)
TreeFam:
Gene Tree for TMEM106C (if available)

Paralogs for TMEM106C Gene

Paralogs for TMEM106C Gene

Selected SIMAP similar genes for TMEM106C Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with TMEM106C: view

Variants for TMEM106C Gene

Sequence variations from dbSNP and Humsavar for TMEM106C Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs6823 -- 47,968,629(+) GAAGT(C/G)GCAGC utr-variant-3-prime
rs1052761 -- 47,968,544(+) TGGTT(C/T)TAGGT utr-variant-3-prime
rs1859446 -- 47,968,413(-) TCTGA(G/T)AAACA utr-variant-3-prime
rs1859447 -- 47,968,393(-) CCATA(A/G)GGAGG utr-variant-3-prime
rs1859448 -- 47,963,936(-) TGGGG(C/T)ACCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM106C Gene

Variant ID Type Subtype PubMed ID
nsv832401 CNV Loss 17160897
nsv519174 CNV Loss 19592680
nsv899061 CNV Loss 21882294

Relevant External Links for TMEM106C Gene

HapMap Linkage Disequilibrium report
TMEM106C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM106C Gene

Disorders for TMEM106C Gene

(1) University of Copenhagen DISEASES for TMEM106C Gene

genes like me logo Genes that share disorders with TMEM106C: view

No data available for UniProtKB/Swiss-Prot for TMEM106C Gene

Publications for TMEM106C Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y. … Sugano S. (Genome Res. 2004) 3
  3. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4

Products for TMEM106C Gene

  • antibodies-online peptides for TMEM106C
  • antibodies-online antibodies for TMEM106C
  • antibodies-online kits for TMEM106C

Sources for TMEM106C Gene

Back to Top

Content