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Aliases for TMEM106C Gene

Aliases for TMEM106C Gene

  • Transmembrane Protein 106C 2 3 5
  • Endoplasmic Reticulum Membrane Protein Overexpressed In Cancer 4
  • EMOC 4

External Ids for TMEM106C Gene

Previous GeneCards Identifiers for TMEM106C Gene

  • GC12P046645
  • GC12P048357
  • GC12P045389

Summaries for TMEM106C Gene

GeneCards Summary for TMEM106C Gene

TMEM106C (Transmembrane Protein 106C) is a Protein Coding gene. An important paralog of this gene is TMEM106B.

Additional gene information for TMEM106C Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM106C Gene

Genomics for TMEM106C Gene

Regulatory Elements for TMEM106C Gene

Enhancers for TMEM106C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H047887 1.5 FANTOM5 Ensembl ENCODE dbSUPER 18.7 -74.7 -74749 2 CTCF RFX1 GABPA GATA3 POLR2A CREM SPI1 NR2C2 VDR TMEM106C HDAC7 RAPGEF3 SLC48A1 ENSG00000257433 ENSG00000197376 ZNF641 ASB8 ENSG00000205537
GH12H047962 1.3 ENCODE dbSUPER 17.7 +1.1 1081 3 HDGF MLX ARID4B SIN3A GLI4 ZNF2 ZNF121 SLC30A9 GLIS2 ELK1 TMEM106C RPL37P19 COL2A1 ENSG00000205537 RAPGEF3 SLC48A1 ASB8 CCDC184 ZNF641 LOC105369752
GH12H047804 2 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -145.8 -145799 25 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 LOC390314 KANSL2 HDAC7 CCNT1 RAPGEF3 ASB8 VDR SENP1 SLC48A1 LOC102725258
GH12H047942 1 ENCODE dbSUPER 17.7 -19.9 -19890 1 ZBTB10 MAFG ELF1 ZEB2 ZEB1 GATA3 ZNF316 MAFF NR2C1 FOS TMEM106C VDR ENSG00000279840
GH12H048000 1.5 FANTOM5 Ensembl ENCODE 10.3 +38.5 38486 2 PKNOX1 SIN3A ZNF2 GLIS2 KLF7 SP3 WT1 PRDM4 SP7 KLF1 RPL37P19 ZNF641 TMEM106C OR5BK1P COL2A1 ENSG00000258203 LOC105369752
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM106C on UCSC Golden Path with GeneCards custom track

Promoters for TMEM106C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000051480 153 1001 HDGF MLX ARID4B SIN3A GLI4 ZNF2 ZNF121 SLC30A9 GLIS2 ELK1

Genomic Location for TMEM106C Gene

Chromosome:
12
Start:
47,963,547 bp from pter
End:
47,968,878 bp from pter
Size:
5,332 bases
Orientation:
Plus strand

Genomic View for TMEM106C Gene

Genes around TMEM106C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM106C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM106C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM106C Gene

Proteins for TMEM106C Gene

  • Protein details for TMEM106C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BVX2-T106C_HUMAN
    Recommended name:
    Transmembrane protein 106C
    Protein Accession:
    Q9BVX2
    Secondary Accessions:
    • B2R998
    • B7Z5M4
    • Q3B761

    Protein attributes for TMEM106C Gene

    Size:
    250 amino acids
    Molecular mass:
    27875 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM106C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM106C Gene

Post-translational modifications for TMEM106C Gene

  • Ubiquitination at posLast=1717
  • Glycosylation at Asn173 and posLast=186186
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM106C Gene

Domains & Families for TMEM106C Gene

Gene Families for TMEM106C Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMEM106C Gene

Suggested Antigen Peptide Sequences for TMEM106C Gene

Graphical View of Domain Structure for InterPro Entry

Q9BVX2

UniProtKB/Swiss-Prot:

T106C_HUMAN :
  • Belongs to the TMEM106 family.
Family:
  • Belongs to the TMEM106 family.
genes like me logo Genes that share domains with TMEM106C: view

Function for TMEM106C Gene

Phenotypes From GWAS Catalog for TMEM106C Gene

Gene Ontology (GO) - Molecular Function for TMEM106C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TMEM106C: view

Phenotypes for TMEM106C Gene

GenomeRNAi human phenotypes for TMEM106C:
genes like me logo Genes that share phenotypes with TMEM106C: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM106C
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM106C Gene

Localization for TMEM106C Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM106C Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM106C gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 2
nucleus 2
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TMEM106C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IBA,IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM106C: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM106C Gene

Pathways & Interactions for TMEM106C Gene

SuperPathways for TMEM106C Gene

No Data Available

Interacting Proteins for TMEM106C Gene

Gene Ontology (GO) - Biological Process for TMEM106C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM106C: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM106C Gene

Drugs & Compounds for TMEM106C Gene

No Compound Related Data Available

Transcripts for TMEM106C Gene

Unigene Clusters for TMEM106C Gene

Transmembrane protein 106C:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM106C
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM106C Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c ·
SP1: - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - - - - - -
SP6: - - - - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - - - - -
SP9: - - - - - - - - - - -
SP10: - - - - - - - - - -
SP11: - - - -
SP12: - - -
SP13: - - -
SP14: - - - - - - - - - - - -
SP15: -

ExUns: 10d · 10e · 10f · 10g · 10h · 10i · 10j
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for TMEM106C Gene

GeneLoc Exon Structure for
TMEM106C
ECgene alternative splicing isoforms for
TMEM106C

Expression for TMEM106C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM106C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM106C Gene

This gene is overexpressed in Cerebrospinal fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM106C Gene



Protein tissue co-expression partners for TMEM106C Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM106C Gene:

TMEM106C

SOURCE GeneReport for Unigene cluster for TMEM106C Gene:

Hs.596726

Evidence on tissue expression from TISSUES for TMEM106C Gene

  • Skin(4.6)
  • Lung(4.3)
  • Nervous system(4.2)
  • Intestine(3.5)
  • Pancreas(2.8)
  • Blood(2.4)
  • Eye(2.4)
genes like me logo Genes that share expression patterns with TMEM106C: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM106C Gene

Orthologs for TMEM106C Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM106C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM106C 33 34
  • 99.87 (n)
dog
(Canis familiaris)
Mammalia TMEM106C 33 34
  • 91.3 (n)
cow
(Bos Taurus)
Mammalia TMEM106C 33 34
  • 84.41 (n)
mouse
(Mus musculus)
Mammalia Tmem106c 33 16 34
  • 82.05 (n)
rat
(Rattus norvegicus)
Mammalia Tmem106c 33
  • 81.32 (n)
chicken
(Gallus gallus)
Aves TMEM106C 33 34
  • 71.58 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM106C 34
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem106c 33
  • 64.92 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC53571 33
zebrafish
(Danio rerio)
Actinopterygii zgc:153351 33
  • 63.06 (n)
TMEM106C (2 of 2) 34
  • 50 (a)
OneToMany
TMEM106C (1 of 2) 34
  • 49 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 30 (a)
OneToMany
Species where no ortholog for TMEM106C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM106C Gene

ENSEMBL:
Gene Tree for TMEM106C (if available)
TreeFam:
Gene Tree for TMEM106C (if available)

Paralogs for TMEM106C Gene

Paralogs for TMEM106C Gene

genes like me logo Genes that share paralogs with TMEM106C: view

Variants for TMEM106C Gene

Sequence variations from dbSNP and Humsavar for TMEM106C Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000187599 -- 47,965,511(+) CAATC(-/TG)GGGAA intron-variant
rs1000621232 -- 47,965,882(+) GGCAT(C/G)TGGTT reference, missense
rs1000742016 -- 47,965,577(+) TGGGA(A/G)AGTGG intron-variant
rs1001324104 -- 47,964,254(+) CATTC(C/T)GCTGC reference, synonymous-codon
rs1002305185 -- 47,962,650(+) TCCCC(A/G)ATAAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM106C Gene

Variant ID Type Subtype PubMed ID
esv3580262 CNV loss 25503493
nsv519174 CNV loss 19592680
nsv832401 CNV loss 17160897

Variation tolerance for TMEM106C Gene

Residual Variation Intolerance Score: 67.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.61; 86.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM106C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM106C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM106C Gene

Disorders for TMEM106C Gene

Relevant External Links for TMEM106C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM106C

No disorders were found for TMEM106C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM106C Gene

Publications for TMEM106C Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  2. Multifunctional reagents for quantitative proteome-wide analysis of protein modification in human cells and dynamic profiling of protein lipidation during vertebrate development. (PMID: 25807930) Broncel M … Tate EW (Angewandte Chemie (International ed. in English) 2015) 4 60
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 60
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 60

Products for TMEM106C Gene

Sources for TMEM106C Gene

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