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Aliases for TMEM106C Gene

Aliases for TMEM106C Gene

  • Transmembrane Protein 106C 2 3 5
  • Endoplasmic Reticulum Membrane Protein Overexpressed In Cancer 4
  • EMOC 4

External Ids for TMEM106C Gene

Previous GeneCards Identifiers for TMEM106C Gene

  • GC12P046645
  • GC12P048357
  • GC12P045389

Summaries for TMEM106C Gene

GeneCards Summary for TMEM106C Gene

TMEM106C (Transmembrane Protein 106C) is a Protein Coding gene. An important paralog of this gene is TMEM106B.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM106C Gene

Genomics for TMEM106C Gene

Regulatory Elements for TMEM106C Gene

Enhancers for TMEM106C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G047887 1.6 FANTOM5 Ensembl ENCODE dbSUPER 18.7 -74.7 -74749 2.1 CTCF NFIB ZBTB40 FOSL1 GATA3 CTBP1 GATA2 POLR2A FOS FOSL2 VDR TMEM106C HDAC7 RAPGEF3 SLC48A1 ENSG00000257433 OR8S1 ZNF641 ASB8 ENSG00000205537
GH12G047962 1.3 ENCODE dbSUPER 17.7 +1.1 1081 3.3 HDGF PKNOX1 MLX AGO1 ARID4B SIN3A ZNF2 SLC30A9 ZNF207 ZNF143 TMEM106C RPL37P19 COL2A1 ENSG00000205537 RAPGEF3 SLC48A1 CCDC184 ASB8 ZNF641 LOC105369752
GH12G047804 2 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -145.8 -145799 25.6 CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 ZNF143 ZNF263 SP3 TBX21 MEF2D KANSL2 CCNT1 RAPGEF3 LOC390314 ASB8 VDR SENP1 SLC48A1 ENSG00000205537 ENSG00000268069
GH12G047942 1 ENCODE dbSUPER 17.7 -19.9 -19890 1.4 CTCF RAD21 ZEB1 GATA3 ZNF316 SCRT2 FOS ZNF600 MAFK TCF7L2 TMEM106C VDR ENSG00000279840
GH12G048000 1.5 FANTOM5 Ensembl ENCODE 10.3 +38.5 38486 2.9 PKNOX1 SIN3A ZNF2 GLIS2 KLF7 SP3 WT1 PRDM4 SP7 CTCF RPL37P19 ZNF641 OR5BK1P TMEM106C COL2A1 ENSG00000258203 LOC105369752
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM106C on UCSC Golden Path with GeneCards custom track

Promoters for TMEM106C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000051480 153 1001 HDGF MLX AGO1 ARID4B SIN3A GLI4 ZNF2 ZNF48 ZNF121 SLC30A9

Genomic Location for TMEM106C Gene

47,963,547 bp from pter
47,968,878 bp from pter
5,332 bases
Plus strand

Genomic View for TMEM106C Gene

Genes around TMEM106C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM106C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM106C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM106C Gene

Proteins for TMEM106C Gene

  • Protein details for TMEM106C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 106C
    Protein Accession:
    Secondary Accessions:
    • B2R998
    • B7Z5M4
    • Q3B761

    Protein attributes for TMEM106C Gene

    250 amino acids
    Molecular mass:
    27875 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM106C Gene


neXtProt entry for TMEM106C Gene

Post-translational modifications for TMEM106C Gene

  • Ubiquitination at posLast=1717
  • Glycosylation at Asn173 and Asn186
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM106C Gene

Domains & Families for TMEM106C Gene

Protein Domains for TMEM106C Gene

Suggested Antigen Peptide Sequences for TMEM106C Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM106 family.
  • Belongs to the TMEM106 family.
genes like me logo Genes that share domains with TMEM106C: view

No data available for Gene Families for TMEM106C Gene

Function for TMEM106C Gene

Gene Ontology (GO) - Molecular Function for TMEM106C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TMEM106C: view

Phenotypes for TMEM106C Gene

GenomeRNAi human phenotypes for TMEM106C:
genes like me logo Genes that share phenotypes with TMEM106C: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM106C Gene

Localization for TMEM106C Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM106C Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Lipid-anchor.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM106C gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 2
nucleus 2
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TMEM106C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IBA,IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM106C: view

Pathways & Interactions for TMEM106C Gene

SuperPathways for TMEM106C Gene

No Data Available

Interacting Proteins for TMEM106C Gene

Gene Ontology (GO) - Biological Process for TMEM106C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM106C: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM106C Gene

Drugs & Compounds for TMEM106C Gene

No Compound Related Data Available

Transcripts for TMEM106C Gene

Unigene Clusters for TMEM106C Gene

Transmembrane protein 106C:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM106C Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c ·
SP1: - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - - - - - -
SP6: - - - - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - - - - -
SP9: - - - - - - - - - - -
SP10: - - - - - - - - - -
SP11: - - - -
SP12: - - -
SP13: - - -
SP14: - - - - - - - - - - - -
SP15: -

ExUns: 10d · 10e · 10f · 10g · 10h · 10i · 10j

Relevant External Links for TMEM106C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM106C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM106C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM106C Gene

This gene is overexpressed in Cerebrospinal fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM106C Gene

Protein tissue co-expression partners for TMEM106C Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM106C Gene:


SOURCE GeneReport for Unigene cluster for TMEM106C Gene:


Evidence on tissue expression from TISSUES for TMEM106C Gene

  • Skin(4.6)
  • Lung(4.3)
  • Nervous system(4.2)
  • Intestine(3.5)
  • Pancreas(2.8)
  • Blood(2.4)
  • Eye(2.4)
genes like me logo Genes that share expression patterns with TMEM106C: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM106C Gene

Orthologs for TMEM106C Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM106C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM106C 34 35
  • 99.87 (n)
(Canis familiaris)
Mammalia TMEM106C 34 35
  • 91.3 (n)
(Bos Taurus)
Mammalia TMEM106C 34 35
  • 84.41 (n)
(Mus musculus)
Mammalia Tmem106c 34 16 35
  • 82.05 (n)
(Rattus norvegicus)
Mammalia Tmem106c 34
  • 81.32 (n)
(Gallus gallus)
Aves TMEM106C 34 35
  • 71.58 (n)
(Anolis carolinensis)
Reptilia TMEM106C 35
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem106c 34
  • 64.92 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC53571 34
(Danio rerio)
Actinopterygii zgc:153351 34
  • 63.06 (n)
TMEM106C (2 of 2) 35
  • 50 (a)
TMEM106C (1 of 2) 35
  • 49 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 30 (a)
Species where no ortholog for TMEM106C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM106C Gene

Gene Tree for TMEM106C (if available)
Gene Tree for TMEM106C (if available)

Paralogs for TMEM106C Gene

Paralogs for TMEM106C Gene

genes like me logo Genes that share paralogs with TMEM106C: view

Variants for TMEM106C Gene

Sequence variations from dbSNP and Humsavar for TMEM106C Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000187599 -- 47,965,511(+) CAATC(-/TG)GGGAA intron-variant
rs1000621232 -- 47,965,882(+) GGCAT(C/G)TGGTT reference, missense
rs1000742016 -- 47,965,577(+) TGGGA(A/G)AGTGG intron-variant
rs1001324104 -- 47,964,254(+) CATTC(C/T)GCTGC reference, synonymous-codon
rs1002305185 -- 47,962,650(+) TCCCC(A/G)ATAAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM106C Gene

Variant ID Type Subtype PubMed ID
esv3580262 CNV loss 25503493
nsv519174 CNV loss 19592680
nsv832401 CNV loss 17160897

Variation tolerance for TMEM106C Gene

Residual Variation Intolerance Score: 67.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.61; 86.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM106C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM106C Gene

Disorders for TMEM106C Gene

Relevant External Links for TMEM106C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMEM106C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM106C Gene

Publications for TMEM106C Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Multifunctional reagents for quantitative proteome-wide analysis of protein modification in human cells and dynamic profiling of protein lipidation during vertebrate development. (PMID: 25807930) Broncel M. … Tate E.W. (Angew. Chem. Int. Ed. 2015) 4 64
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3 64
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64

Products for TMEM106C Gene

Sources for TMEM106C Gene

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