Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMEM106B Gene

Aliases for TMEM106B Gene

  • Transmembrane Protein 106B 2 3 5

External Ids for TMEM106B Gene

Previous GeneCards Identifiers for TMEM106B Gene

  • GC07P012025

Summaries for TMEM106B Gene

GeneCards Summary for TMEM106B Gene

TMEM106B (Transmembrane Protein 106B) is a Protein Coding gene. Diseases associated with TMEM106B include frontotemporal dementia and/or amyotrophic lateral sclerosis 1 and ftdals1. An important paralog of this gene is TMEM106C.

UniProtKB/Swiss-Prot for TMEM106B Gene

  • Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with MAP6. May act by inhibiting retrograde transport of lysosomes along dendrites. Required for dendrite branching.

Gene Wiki entry for TMEM106B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM106B Gene

Genomics for TMEM106B Gene

Regulatory Elements for TMEM106B Gene

Promoters for TMEM106B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM106B on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM106B Gene

Chromosome:
7
Start:
12,211,222 bp from pter
End:
12,243,367 bp from pter
Size:
32,146 bases
Orientation:
Plus strand

Genomic View for TMEM106B Gene

Genes around TMEM106B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM106B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM106B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM106B Gene

Proteins for TMEM106B Gene

  • Protein details for TMEM106B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NUM4-T106B_HUMAN
    Recommended name:
    Transmembrane protein 106B
    Protein Accession:
    Q9NUM4
    Secondary Accessions:
    • A4D108
    • Q53FL9
    • Q8N4L0

    Protein attributes for TMEM106B Gene

    Size:
    274 amino acids
    Molecular mass:
    31127 Da
    Quaternary structure:
    • Interacts with MAP6.

neXtProt entry for TMEM106B Gene

Proteomics data for TMEM106B Gene at MOPED

Post-translational modifications for TMEM106B Gene

  • Ubiquitination at Lys 14
  • Glycosylation at Asn 145, Asn 151, Asn 164, Asn 183, and Asn 256
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM106B Gene

Antibody Products

No data available for DME Specific Peptides for TMEM106B Gene

Domains & Families for TMEM106B Gene

Protein Domains for TMEM106B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM106B Gene

Graphical View of Domain Structure for InterPro Entry

Q9NUM4

UniProtKB/Swiss-Prot:

T106B_HUMAN :
  • Belongs to the TMEM106 family.
Family:
  • Belongs to the TMEM106 family.
genes like me logo Genes that share domains with TMEM106B: view

No data available for Gene Families for TMEM106B Gene

Function for TMEM106B Gene

Molecular function for TMEM106B Gene

UniProtKB/Swiss-Prot Function:
Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with MAP6. May act by inhibiting retrograde transport of lysosomes along dendrites. Required for dendrite branching.

Phenotypes for TMEM106B Gene

genes like me logo Genes that share phenotypes with TMEM106B: view

Animal Models for TMEM106B Gene

MGI Knock Outs for TMEM106B:

Animal Model Products

CRISPR Products

miRNA for TMEM106B Gene

miRTarBase miRNAs that target TMEM106B

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM106B Gene

Localization for TMEM106B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM106B Gene

Late endosome membrane; Single-pass type II membrane protein. Lysosome membrane; Single-pass type II membrane protein. Membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM106B Gene COMPARTMENTS Subcellular localization image for TMEM106B gene
Compartment Confidence
extracellular 5
lysosome 5
vacuole 5
endosome 4
plasma membrane 3
nucleus 1

Gene Ontology (GO) - Cellular Components for TMEM106B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IDA 24357581
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with TMEM106B: view

Pathways & Interactions for TMEM106B Gene

SuperPathways for TMEM106B Gene

No Data Available

Interacting Proteins for TMEM106B Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000379901%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000307093%0d%0a9606.ENSP00000333298%0d%0a
Selected Interacting proteins: ENSP00000379901 for TMEM106B Gene via STRING

Gene Ontology (GO) - Biological Process for TMEM106B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM106B Gene

Drugs & Compounds for TMEM106B Gene

No Compound Related Data Available

Transcripts for TMEM106B Gene

Unigene Clusters for TMEM106B Gene

Transmembrane protein 106B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM106B Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - -
SP5: - - - -
SP6: - - - -
SP7: -
SP8: -
SP9: - -
SP10: -

Relevant External Links for TMEM106B Gene

GeneLoc Exon Structure for
TMEM106B
ECgene alternative splicing isoforms for
TMEM106B

Expression for TMEM106B Gene

mRNA expression in normal human tissues for TMEM106B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM106B Gene

This gene is overexpressed in Adrenal (14.8), Breast (8.4), Amniocyte (8.1), Testis (6.8), and Pancreas (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM106B Gene



SOURCE GeneReport for Unigene cluster for TMEM106B Gene Hs.396358

mRNA Expression by UniProt/SwissProt for TMEM106B Gene

Q9NUM4-T106B_HUMAN
Tissue specificity: Expressed in frontal cortex.
genes like me logo Genes that share expression patterns with TMEM106B: view

Protein tissue co-expression partners for TMEM106B Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TMEM106B Gene

Orthologs for TMEM106B Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM106B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM106B 35
  • 100 (n)
  • 100 (a)
TMEM106B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM106B 36
  • 95 (a)
OneToOne
TMEM106B 35
  • 90.75 (n)
  • 95.62 (a)
dog
(Canis familiaris)
Mammalia TMEM106B 35
  • 93.8 (n)
  • 96.35 (a)
-- 36
  • 82 (a)
OneToMany
-- 36
  • 90 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Tmem106b 16
Tmem106b 36
  • 95 (a)
OneToOne
Tmem106b 35
  • 88.81 (n)
  • 95.99 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM106B 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM106B 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem106b 35
  • 87.96 (n)
  • 95.26 (a)
chicken
(Gallus gallus)
Aves TMEM106B 35
  • 80.17 (n)
  • 87.59 (a)
lizard
(Anolis carolinensis)
Reptilia TMEM106B 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem106b 35
  • 67.4 (n)
  • 69.74 (a)
zebrafish
(Danio rerio)
Actinopterygii tmem106bb 36
  • 72 (a)
OneToOne
tmem106bb 35
  • 68.77 (n)
  • 76.68 (a)
zgc64013 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToMany
Species with no ortholog for TMEM106B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM106B Gene

ENSEMBL:
Gene Tree for TMEM106B (if available)
TreeFam:
Gene Tree for TMEM106B (if available)

Paralogs for TMEM106B Gene

Paralogs for TMEM106B Gene

(5) SIMAP similar genes for TMEM106B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TMEM106B: view

Variants for TMEM106B Gene

Sequence variations from dbSNP and Humsavar for TMEM106B Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs3173615 - 12,229,791(+) CATAA(C/G)CATTA reference, missense
rs1468800 -- 12,212,517(-) GAGAT(A/T)TTCAC intron-variant
rs1468801 -- 12,236,419(-) TTAAT(C/G)CAACA utr-variant-3-prime
rs1468802 -- 12,236,385(-) TACTA(C/T)ATTTT utr-variant-3-prime
rs1054167 -- 12,233,577(+) TTTTT(G/T)TTTTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TMEM106B Gene

Variant ID Type Subtype PubMed ID
nsv819594 CNV Loss 19587683

Variation tolerance for TMEM106B Gene

Residual Variation Intolerance Score: 33.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.28; 25.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM106B Gene

HapMap Linkage Disequilibrium report
TMEM106B
Human Gene Mutation Database (HGMD)
TMEM106B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM106B Gene

Disorders for TMEM106B Gene

MalaCards: The human disease database

(6) MalaCards diseases for TMEM106B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
frontotemporal dementia and/or amyotrophic lateral sclerosis 1
  • ftdals1
ftdals1
  • frontotemporal dementia and/or amyotrophic lateral sclerosis 1
basal ganglia disease
  • disorder of basal ganglia
dementia
  • presenile dementia
dementia, frontotemporal
  • dementia, frontotemporal, with or without parkinsonism
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

T106B_HUMAN
  • Ubiquitin-positive frontotemporal dementia (UP-FTD) [MIM:607485]: Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease. {ECO:0000269 PubMed:20154673, ECO:0000269 PubMed:21178100, ECO:0000269 PubMed:22895706, ECO:0000269 PubMed:23742080}. Note=The gene represented in this entry acts as a disease modifier. Risk alleles confer genetic susceptibility by increasing gene expression (PubMed:20154673, PubMed:21178100). Increased expression may be the result of down-regulation of microRNA miR-132 and miR-212, that repress TMEM106B expression (PubMed:22895706). Thr-185 is a risk allele associated with lower GRN protein levels and early age at onset in GRN UP-FTD mutation carriers: it presents slower protein degradation that leads to higher steady-state TMEM106B levels, leading to alterations in the intracellular versus extracellular partitioning of GRN (PubMed:23742080). {ECO:0000269 PubMed:20154673, ECO:0000269 PubMed:21178100, ECO:0000269 PubMed:22895706, ECO:0000269 PubMed:23742080}.
  • Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 (FTDALS1) [MIM:105550]: An autosomal dominant neurodegenerative disorder characterized by adult onset of frontotemporal dementia and/or amyotrophic lateral sclerosis in an affected individual. There is high intrafamilial variation. Frontotemporal dementia is characterized by frontal and temporal lobe atrophy associated with neuronal loss, gliosis, and dementia. Patients exhibit progressive changes in social, behavioral, and/or language function. Amyotrophic lateral sclerosis is characterized by the death of motor neurons in the brain, brainstem, and spinal cord, resulting in fatal paralysis. {ECO:0000269 PubMed:24385136, ECO:0000269 PubMed:24442578, ECO:0000303 PubMed:24488309}. Note=The gene represented in this entry acts as a disease modifier.

Relevant External Links for TMEM106B

Genetic Association Database (GAD)
TMEM106B
Human Genome Epidemiology (HuGE) Navigator
TMEM106B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM106B
genes like me logo Genes that share disorders with TMEM106B: view

No data available for Genatlas for TMEM106B Gene

Publications for TMEM106B Gene

  1. Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. (PMID: 20154673) Van Deerlin V.M. … Lee V.M. (Nat. Genet. 2010) 2 3 4 48 67
  2. Membrane orientation and subcellular localization of transmembrane protein 106B (TMEM106B), a major risk factor for frontotemporal lobar degeneration. (PMID: 22511793) Lang C.M. … Haass C. (J. Biol. Chem. 2012) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. The TMEM106B locus and TDP-43 pathology in older persons without FTLD. (PMID: 25653292) Yu L. … Schneider J.A. (Neurology 2015) 3
  5. Reassessment of risk genotypes (GRN, TMEM106B, and ABCC9 variants) associated with hippocampal sclerosis of aging pathology. (PMID: 25470345) Nelson P.T. … Fardo D.W. (J. Neuropathol. Exp. Neurol. 2015) 3

Products for TMEM106B Gene

Sources for TMEM106B Gene

Back to Top

Content