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Aliases for TMEM106B Gene

Aliases for TMEM106B Gene

  • Transmembrane Protein 106B 2 3

External Ids for TMEM106B Gene

Summaries for TMEM106B Gene

GeneCards Summary for TMEM106B Gene

TMEM106B (Transmembrane Protein 106B) is a Protein Coding gene. An important paralog of this gene is TMEM106C.

UniProtKB/Swiss-Prot for TMEM106B Gene

  • Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with MAP6. May act by inhibiting retrograde transport of lysosomes along dendrites. Required for dendrite branching.

Gene Wiki entry for TMEM106B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM106B Gene

Genomics for TMEM106B Gene

Genomic Location for TMEM106B Gene

Start:
12,211,203 bp from pter
End:
12,243,367 bp from pter
Size:
32,165 bases
Orientation:
Plus strand

Genomic View for TMEM106B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM106B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM106B Gene

Regulatory Elements for TMEM106B Gene

Proteins for TMEM106B Gene

  • Protein details for TMEM106B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NUM4-T106B_HUMAN
    Recommended name:
    Transmembrane protein 106B
    Protein Accession:
    Q9NUM4
    Secondary Accessions:
    • A4D108
    • Q53FL9
    • Q8N4L0

    Protein attributes for TMEM106B Gene

    Size:
    274 amino acids
    Molecular mass:
    31127 Da
    Quaternary structure:
    • Interacts with MAP6.

neXtProt entry for TMEM106B Gene

Proteomics data for TMEM106B Gene at MOPED

Post-translational modifications for TMEM106B Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys14
  • Glycosylation at Asn145, Asn151, Asn164, Asn183, and Asn256

Other Protein References for TMEM106B Gene

No data available for DME Specific Peptides for TMEM106B Gene

Domains for TMEM106B Gene

Protein Domains for TMEM106B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM106B Gene

Graphical View of Domain Structure for InterPro Entry

Q9NUM4

UniProtKB/Swiss-Prot:

T106B_HUMAN
Family:
  • Belongs to the TMEM106 family.:
    • Q9NUM4
genes like me logo Genes that share domains with TMEM106B: view

No data available for Gene Families for TMEM106B Gene

Function for TMEM106B Gene

Molecular function for TMEM106B Gene

UniProtKB/Swiss-Prot Function: Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with MAP6. May act by inhibiting retrograde transport of lysosomes along dendrites. Required for dendrite branching.

Gene Ontology (GO) - Molecular Function for TMEM106B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 24357581
genes like me logo Genes that share ontologies with TMEM106B: view

miRNA for TMEM106B Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM106B Gene

Localization for TMEM106B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM106B Gene

Late endosome membrane; Single-pass type II membrane protein. Lysosome membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM106B Gene COMPARTMENTS Subcellular localization image for TMEM106B gene
Compartment Confidence
endosome 5
lysosome 5
vacuole 5
plasma membrane 3
nucleus 1

Gene Ontology (GO) - Cellular Components for TMEM106B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IDA 24357581
GO:0005768 endosome --
GO:0016021 integral component of membrane IEA --
GO:0031902 late endosome membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with TMEM106B: view

Pathways for TMEM106B Gene

SuperPathways for TMEM106B Gene

No Data Available

Interacting Proteins for TMEM106B Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000379901%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000307093%0d%0a9606.ENSP00000333298%0d%0a
Selected Interacting proteins: ENSP00000379901 for TMEM106B Gene via STRING

Gene Ontology (GO) - Biological Process for TMEM106B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0008219 cell death --
GO:0032418 lysosome localization IMP 24357581
GO:0048813 dendrite morphogenesis IMP 24357581
genes like me logo Genes that share ontologies with TMEM106B: view

No data available for Pathways by source for TMEM106B Gene

Transcripts for TMEM106B Gene

Unigene Clusters for TMEM106B Gene

Transmembrane protein 106B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM106B Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - -
SP5: - - - -
SP6: - - - -
SP7: -
SP8: -
SP9: - -
SP10: -

Relevant External Links for TMEM106B Gene

GeneLoc Exon Structure for
TMEM106B
ECgene alternative splicing isoforms for
TMEM106B

Expression for TMEM106B Gene

mRNA expression in normal human tissues for TMEM106B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM106B Gene

SOURCE GeneReport for Unigene cluster for TMEM106B Gene Hs.396358

mRNA Expression by UniProt/SwissProt for TMEM106B Gene

Q9NUM4-T106B_HUMAN
Tissue specificity: Expressed in frontal cortex
genes like me logo Genes that share expressions with TMEM106B: view

No data available for mRNA differential expression in normal tissues for TMEM106B Gene

Orthologs for TMEM106B Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM106B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM106B 35
  • 100 (n)
  • 100 (a)
TMEM106B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM106B 35
  • 90.75 (n)
  • 95.62 (a)
TMEM106B 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 82 (a)
OneToMany
-- 36
  • 90 (a)
OneToMany
TMEM106B 35
  • 93.8 (n)
  • 96.35 (a)
mouse
(Mus musculus)
Mammalia Tmem106b 35
  • 88.81 (n)
  • 95.99 (a)
Tmem106b 16
Tmem106b 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM106B 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM106B 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem106b 35
  • 87.96 (n)
  • 95.26 (a)
chicken
(Gallus gallus)
Aves TMEM106B 35
  • 80.17 (n)
  • 87.59 (a)
lizard
(Anolis carolinensis)
Reptilia TMEM106B 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem106b 35
  • 67.4 (n)
  • 69.74 (a)
zebrafish
(Danio rerio)
Actinopterygii tmem106bb 35
  • 68.77 (n)
  • 76.68 (a)
tmem106bb 36
  • 72 (a)
OneToOne
zgc64013 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToMany
Species with no ortholog for TMEM106B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM106B Gene

ENSEMBL:
Gene Tree for TMEM106B (if available)
TreeFam:
Gene Tree for TMEM106B (if available)

Paralogs for TMEM106B Gene

Paralogs for TMEM106B Gene

Selected SIMAP similar genes for TMEM106B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TMEM106B: view

Variants for TMEM106B Gene

Sequence variations from dbSNP and Humsavar for TMEM106B Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs14978 -- 12,233,526(-) AAAAC(C/T)TGCAG utr-variant-3-prime
rs929637 -- 12,236,896(-) AAGCA(A/C)GTCAA utr-variant-3-prime
rs1019306 -- 12,212,200(-) AGGCA(A/G)ACTCA intron-variant
rs1019307 -- 12,212,164(-) TCTGT(C/G)CTAAT intron-variant
rs1019308 -- 12,212,100(-) AGACT(C/G)TGTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM106B Gene

Variant ID Type Subtype PubMed ID
nsv819594 CNV Loss 19587683

Relevant External Links for TMEM106B Gene

HapMap Linkage Disequilibrium report
TMEM106B
Human Gene Mutation Database (HGMD)
TMEM106B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM106B Gene

Disorders for TMEM106B Gene

UniProtKB/Swiss-Prot

T106B_HUMAN
  • Ubiquitin-positive frontotemporal dementia (UP-FTD) [MIM:607485]: Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease. Note=The gene represented in this entry acts as a disease modifier. Risk alleles confer genetic susceptibility by increasing gene expression (PubMed:20154673, PubMed:21178100). Increased expression may be the result of down-regulation of microRNA miR-132 and miR-212, that repress TMEM106B expression (PubMed:22895706). Thr-185 is a risk allele associated with lower GRN protein levels and early age at onset in GRN UP-FTD mutation carriers: it presents slower protein degradation that leads to higher steady-state TMEM106B levels, leading to alterations in the intracellular versus extracellular partitioning of GRN (PubMed:23742080). {ECO:0000269 PubMed:20154673, ECO:0000269 PubMed:21178100, ECO:0000269 PubMed:22895706, ECO:0000269 PubMed:23742080}.
  • Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 (FTDALS1) [MIM:105550]: An autosomal dominant neurodegenerative disorder characterized by adult onset of frontotemporal dementia and/or amyotrophic lateral sclerosis in an affected individual. There is high intrafamilial variation. Frontotemporal dementia is characterized by frontal and temporal lobe atrophy associated with neuronal loss, gliosis, and dementia. Patients exhibit progressive changes in social, behavioral, and/or language function. Amyotrophic lateral sclerosis is characterized by the death of motor neurons in the brain, brainstem, and spinal cord, resulting in fatal paralysis. {ECO:0000269 PubMed:24385136, ECO:0000269 PubMed:24442578, ECO:0000303 PubMed:24488309}. Note=The gene represented in this entry acts as a disease modifier.

(1) University of Copenhagen DISEASES for TMEM106B Gene

Relevant External Links for TMEM106B

Genetic Association Database (GAD)
TMEM106B
Human Genome Epidemiology (HuGE) Navigator
TMEM106B
genes like me logo Genes that share disorders with TMEM106B: view

Publications for TMEM106B Gene

  1. Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. (PMID: 20154673) Van Deerlin V.M. … Lee V.M. (Nat. Genet. 2010) 2 3 4 48
  2. Membrane orientation and subcellular localization of transmembrane protein 106B (TMEM106B), a major risk factor for frontotemporal lobar degeneration. (PMID: 22511793) Lang C.M. … Haass C. (J. Biol. Chem. 2012) 2 3 4
  3. The frontotemporal lobar degeneration risk factor, TMEM106B, regulates lysosomal morphology and function. (PMID: 23136129) Brady O.A. … Hu F. (Hum. Mol. Genet. 2013) 3 4
  4. TMEM106B, the risk gene for frontotemporal dementia, is regulated by the microRNA-132/212 cluster and affects progranulin pathways. (PMID: 22895706) Chen-Plotkin A.S. … Lee V.M. (J. Neurosci. 2012) 3 4
  5. TMEM106B p.T185S regulates TMEM106B protein levels: implications for frontotemporal dementia. (PMID: 23742080) Nicholson A.M. … Rademakers R. (J. Neurochem. 2013) 3 4

Products for TMEM106B Gene

Sources for TMEM106B Gene

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