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TMEM106B Gene

protein-coding   GIFtS: 54
GCID: GC07P012217

Transmembrane Protein 106B

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Protein 106B1 2

External Ids:    HGNC: 224071   Entrez Gene: 546642   Ensembl: ENSG000001064607   OMIM: 6134135   UniProtKB: Q9NUM43   

Export aliases for TMEM106B gene to outside databases

Previous GC identifer: GC07P012025


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMEM106B Gene:
TMEM106B (transmembrane protein 106B) is a protein-coding gene. Diseases associated with TMEM106B include frontotemporal dementia, and dementia. An important paralog of this gene is TMEM106A.

Gene Wiki entry for TMEM106B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007819.18  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMEM106B gene promoter:
         ISGF-3   Tal-1beta   E4BP4   E47   NF-AT   NF-AT4   NF-AT2   NF-AT3   ITF-2   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM106B promoter sequence
   Search Chromatin IP Primers for TMEM106B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM106B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p21.3   Ensembl cytogenetic band:  7p21.3   HGNC cytogenetic band: 7p21.3

TMEM106B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM106B gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P012217:  view genomic region     (about GC identifiers)

Start:
12,250,848 bp from pter      End:
12,282,993 bp from pter
Size:
32,146 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 12,304,117-12,330,178     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: T106B_HUMAN, Q9NUM4 (See protein sequence)
Recommended Name: Transmembrane protein 106B  
Size: 274 amino acids; 31127 Da
Secondary accessions: A4D108 Q53FL9 Q8N4L0

Explore the universe of human proteins at neXtProt for TMEM106B: NX_Q9NUM4

Explore proteomics data for TMEM106B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys14
  • Glycosylation2 at Asn145, Asn151, Asn164, Asn183, Asn256
  • Modification sites at PhosphoSitePlus

  • See TMEM106B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001127704.1  NP_060844.2  

    ENSEMBL proteins: 
     ENSP00000379902   ENSP00000391016   ENSP00000401302   ENSP00000379901   ENSP00000391985  

    TMEM106B Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for TMEM106B

    TMEM106B Antibody Products:

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    Abcam antibodies for TMEM106B
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    ThermoFisher Antibodies for TMEM106B
    LSBio Antibodies in human, mouse, rat for TMEM106B

    TMEM106B Assay Products:

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    Cloud-Clone Corp. ELISAs for TMEM106B
    Cloud-Clone Corp. CLIAs for TMEM106B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR009790 DUF1356_TMEM106

    Graphical View of Domain Structure for InterPro Entry Q9NUM4

    ProtoNet protein and cluster: Q9NUM4

    UniProtKB/Swiss-Prot: T106B_HUMAN, Q9NUM4
    Similarity: Belongs to the TMEM106 family


    TMEM106B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding IPI--
         
    TMEM106B for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Tmem106b (no phenotypes)

    TMEM106B for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMEM106B
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMEM106B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMEM106B

    miRNA
    Products:
        
    miRTarBase miRNAs that target TMEM106B:
    hsa-mir-877-5p (MIRT037240), hsa-mir-30b-5p (MIRT046151), hsa-mir-375 (MIRT019872), hsa-mir-10a-5p (MIRT047527)

    Block miRNA regulation of human, mouse, rat TMEM106B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TMEM106B (see all 69):
    hsa-miR-579 hsa-miR-323-3p hsa-miR-607 hsa-miR-485-3p hsa-miR-30d hsa-miR-371-5p hsa-miR-4275 hsa-miR-30a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TMEM106B
    Predesigned siRNA for gene silencing in human, mouse, rat TMEM106B

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): TMEM106B (NM_018374)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM106B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM106B

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM106B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    T106B_HUMAN, Q9NUM4: Late endosome membrane; Single-pass type II membrane protein. Lysosome membrane; Single-pass
    type II membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    lysosome5
    vacuole5
    plasma membrane3
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005765lysosomal membrane IDA--
    GO:0016021integral component of membrane IEA--
    GO:0031902late endosome membrane IEA--

    TMEM106B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM106B
    Interactions:

        Search GeneGlobe Interaction Network for TMEM106B

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--
    GO:0032418lysosome localization IMP--
    GO:0048813dendrite morphogenesis IMP--

    TMEM106B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMEM106B (T106B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TMEM106B gene (2 alternative transcripts): 
    NM_001134232.1  NM_018374.3  

    Unigene Cluster for TMEM106B:

    Transmembrane protein 106B
    Hs.396358  [show with all ESTs]
    Unigene Representative Sequence: NM_018374
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396668 ENST00000420833 ENST00000444443 ENST00000396667(uc011jxk.2 uc003ssh.3)
    ENST00000453686 ENST00000442107 ENST00000492762 ENST00000462754

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TMEM106B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TMEM106B (see all 69):
    hsa-miR-579 hsa-miR-323-3p hsa-miR-607 hsa-miR-485-3p hsa-miR-30d hsa-miR-371-5p hsa-miR-4275 hsa-miR-30a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TMEM106B
    Predesigned siRNA for gene silencing in human, mouse, rat TMEM106B
    Clone
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    OriGene clones in human, mouse for TMEM106B (see all 11)
    OriGene ORF clones in mouse, rat for TMEM106B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TMEM106B (NM_018374)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM106B
    Primer
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    OriGene qPCR primer pairs and template standards for TMEM106B
    OriGene qSTAR qPCR primer pairs in human, mouse for TMEM106B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMEM106B
      QuantiTect SYBR Green Assays in human, mouse, rat TMEM106B
      QuantiFast Probe-based Assays in human, mouse, rat TMEM106B

    Additional mRNA sequence: 

    AK001834.1 AK002135.1 AK090805.1 AK223263.1 AK311651.1 BC028108.1 BC033901.2 BC039741.2 
    Z36806.1 

    12 DOTS entries:

    DT.114295  DT.100025181  DT.100025182  DT.92324152  DT.40114893  DT.100795422  DT.101973565  DT.92430192 
    DT.95365000  DT.97785316  DT.92058859  DT.99955238 

    Selected AceView cDNA sequences (see all 244):

    AA912824 BE048846 BX327814 CR624005 AA730220 CB250427 AA128820 AA603809 
    BQ424563 CF529047 BM788784 N22544 AA907651 AL600186 AA304566 BE218870 
    BU160544 AA504163 AA719565 CK299671 AA730273 AI015782 BU607560 N50372 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TMEM106B (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d
    SP1:                    -                       -     -           -                             -                 -                           
    SP2:                    -     -                 -     -           -                             -                 -                           
    SP3:                                            -     -           -                 -     -     -                 -                           
    SP4:                                                              -                             -           -     -                           
    SP5:                    -     -                 -     -                                                                                       


    ECgene alternative splicing isoforms for TMEM106B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMEM106B expression in normal human tissues (normalized intensities)      TMEM106B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TMEM106B Expression
    About this image


    TMEM106B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Thymus (Hematopoietic System)
             T-Cytotoxic Cells Thymus
     
     Blood (Cardiovascular System)
             T-Cytotoxic Cells Thymus
    TMEM106B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMEM106B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.396358

    UniProtKB/Swiss-Prot: T106B_HUMAN, Q9NUM4
    Tissue specificity: Expressed in frontal cortex

        Custom PCR Arrays for TMEM106B
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TMEM106B gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem106b1 , 5 transmembrane protein 106B1, 5 88.81(n)1
    95.99(a)1
      6 (5.38 cM)5
    719001  NM_027992.31  NP_082268.21 
     130697595 
    chicken
    (Gallus gallus)
    Aves TMEM106B1 transmembrane protein 106B 80.17(n)
    87.59(a)
      420586  NM_001012558.1  NP_001012576.1 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM106B6
    transmembrane protein 106B
    88(a)
    1 ↔ 1
    6(25606934-25630442)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tmem106b1 transmembrane protein 106B 67.4(n)
    69.74(a)
      549566  NM_001016812.2  NP_001016812.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc640132 hypothetical protein MGC64013 78.07(n)   393333  BC053198.1 


    ENSEMBL Gene Tree for TMEM106B (if available)
    TreeFam Gene Tree for TMEM106B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TMEM106B gene
    TMEM106A2  TMEM106C2  
    5 SIMAP similar genes for TMEM106B using alignment to 5 protein entries:     T106B_HUMAN (see all proteins):
    MRPS28    TMEM106C    L3MBTL2    ETFA    TMEM106A

    TMEM106B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMEM106B (see all 758)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1880829471,2
    --12248892(+) ATAACC/GCTTTG 2 -- us2k10--------
    rs1480605581,2
    --12248895(+) ACCCTC/TTGAGA 2 -- us2k10--------
    rs725822421,2
    C,F--12249139(+) TGTGCT/CATATG 2 -- us2k13Minor allele frequency- C:0.06WA NA EA 358
    rs1436863851,2
    C--12249146(+) TATGGA/CCAGCA 2 -- us2k10--------
    rs1472027021,2
    --12249183(+) GAAAAC/TACTAA 2 -- us2k10--------
    rs1931025321,2
    --12249231(+) CACTTA/CAGAAT 2 -- us2k10--------
    rs1851296671,2
    --12249232(+) ACTTAA/GGAATA 2 -- us2k10--------
    rs789806031,2
    C,F--12249248(+) TATTAC/TATTAT 2 -- us2k12Minor allele frequency- T:0.11NA EA 240
    rs1900602081,2
    --12249336(+) TATATG/TTCTTT 2 -- us2k10--------
    rs783251541,2
    C,F--12249393(+) ATATGT/AGAATA 2 -- us2k11Minor allele frequency- A:0.07EA 120

    HapMap Linkage Disequilibrium report for TMEM106B (12250848 - 12282993 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TMEM106B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv819594CNV Loss19587683

    Human Gene Mutation Database (HGMD): TMEM106B
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing TMEM106B
    DNA2.0 Custom Variant and Variant Library Synthesis for TMEM106B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613413    OMIM disorders: --

    UniProtKB/Swiss-Prot: T106B_HUMAN, Q9NUM4
  • Note=TMEM106B genotype, when containing 3 particular single-nucleotide polymorphisms, is strongly
    correlated with frontotemporal lobar degeneration with TAR DNA-binding protein (TDP-43) inclusions (FTLD-TDP).
    Frontotemporal lobar degeneration (FTLD) is the second most common cause of presenile dementia and 20% of
    patients with this neurodegenerative disease have autosomal dominant GRN mutations. Expression of TMEM106B
    associated with these polymorphisms is increased in frontal cortex of patients with FTLD-TDP compared to
    unaffected controls. Thus, increased TMEM106B expression in the brain may be linked to mechanisms of disease in
    FTLD-TDP and risk alleles confer genetic susceptibility by increasing gene expression

  • 8 diseases for TMEM106B:    About MalaCards
    frontotemporal dementia    dementia    lateral sclerosis    amyotrophic lateral sclerosis
    alzheimer's disease    multiple myeloma    myeloma    lung cancer

    1 disease from the University of Copenhagen DISEASES database for TMEM106B:
    Frontotemporal dementia

    TMEM106B for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): TMEM106B
    Human Genome Epidemiology (HuGE) Navigator: TMEM106B (5 documents)

    Export disorders for TMEM106B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMEM106B gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with TMEM106B)
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    1. Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. (PubMed id 20154673)1, 2, 3, 4 Van Deerlin V.M.... Lee V.M. (Nat. Genet. 2010)
    2. Membrane orientation and subcellular localization of transmembrane protein 106B (TMEM106B), a major risk factor for frontotemporal lobar degeneration. (PubMed id 22511793)1, 2, 3 Lang C.M.... Haass C. (J. Biol. Chem. 2012)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    7. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    8. Genome-wide association study of Tourette's syndrome. (PubMed id 22889924)1 Scharf J.M....Pauls D.L. (Mol. Psychiatry 2013)
    9. The frontotemporal lobar degeneration risk factor, TMEM106B, regulates lysosomal morphology and function. (PubMed id 23136129)1 Brady O.A....Hu F. (Hum. Mol. Genet. 2013)
    10. Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. (PubMed id 23648065)1 Low S.K....Nakamura Y. (Cancer Sci. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54664 HGNC: 22407 AceView: FLJ11273 Ensembl:ENSG00000106460 euGenes: HUgn54664
    ECgene: TMEM106B H-InvDB: TMEM106B

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TMEM106B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMEM106B gene:
    Search GeneIP for patents involving TMEM106B

    GeneCards and IP:
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