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Aliases for TMEM106A Gene

Aliases for TMEM106A Gene

  • Transmembrane Protein 106A 2 3

External Ids for TMEM106A Gene

Previous GeneCards Identifiers for TMEM106A Gene

  • GC17P038720
  • GC17P041363
  • GC17P037130

Summaries for TMEM106A Gene

GeneCards Summary for TMEM106A Gene

TMEM106A (Transmembrane Protein 106A) is a Protein Coding gene. An important paralog of this gene is TMEM106C.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM106A Gene

Genomics for TMEM106A Gene

Regulatory Elements for TMEM106A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMEM106A Gene

43,211,827 bp from pter
43,220,041 bp from pter
8,215 bases
Plus strand

Genomic View for TMEM106A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM106A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM106A Gene

Proteins for TMEM106A Gene

  • Protein details for TMEM106A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 106A
    Protein Accession:
    Secondary Accessions:
    • A8K2X2
    • B7Z698

    Protein attributes for TMEM106A Gene

    262 amino acids
    Molecular mass:
    28920 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM106A Gene


neXtProt entry for TMEM106A Gene

Proteomics data for TMEM106A Gene at MOPED

Post-translational modifications for TMEM106A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM106A Gene

No data available for DME Specific Peptides for TMEM106A Gene

Domains for TMEM106A Gene

Protein Domains for TMEM106A Gene


Graphical View of Domain Structure for InterPro Entry



  • Q96A25
  • Belongs to the TMEM106 family.
genes like me logo Genes that share domains with TMEM106A: view

No data available for Gene Families for TMEM106A Gene

Function for TMEM106A Gene

Gene Ontology (GO) - Molecular Function for TMEM106A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM106A: view

miRNA for TMEM106A Gene

miRTarBase miRNAs that target TMEM106A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM106A Gene

Localization for TMEM106A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM106A Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMEM106A Gene COMPARTMENTS Subcellular localization image for TMEM106A gene
Compartment Confidence
plasma membrane 3
extracellular 2
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMEM106A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with TMEM106A: view

Pathways for TMEM106A Gene

SuperPathways for TMEM106A Gene

No Data Available

Interacting Proteins for TMEM106A Gene

Gene Ontology (GO) - Biological Process for TMEM106A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM106A: view

No data available for Pathways by source for TMEM106A Gene

Transcripts for TMEM106A Gene

Unigene Clusters for TMEM106A Gene

Transmembrane protein 106A:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM106A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM106A Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9
SP1: - - - -
SP2: - - -
SP3: - -
SP4: - -
SP6: -

Relevant External Links for TMEM106A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM106A Gene

mRNA expression in normal human tissues for TMEM106A Gene

Protein differential expression in normal tissues for TMEM106A Gene

This gene is overexpressed in Urine (67.5).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TMEM106A Gene

SOURCE GeneReport for Unigene cluster for TMEM106A Gene Hs.536474

genes like me logo Genes that share expressions with TMEM106A: view

Expression partners for TMEM106A Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM106A Gene

Orthologs for TMEM106A Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM106A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMEM106A 35
  • 85.44 (n)
  • 80.08 (a)
TMEM106A 36
  • 79 (a)
(Canis familiaris)
Mammalia TMEM106A 35
  • 87.69 (n)
  • 85.38 (a)
TMEM106A 36
  • 83 (a)
(Mus musculus)
Mammalia Tmem106a 35
  • 77.44 (n)
  • 66.92 (a)
Tmem106a 16
Tmem106a 36
  • 65 (a)
(Pan troglodytes)
Mammalia TMEM106A 35
  • 99.37 (n)
  • 99.53 (a)
TMEM106A 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Tmem106a 35
  • 78.08 (n)
  • 67.69 (a)
(Monodelphis domestica)
Mammalia TMEM106A 36
  • 61 (a)
(Anolis carolinensis)
Reptilia TMEM106A 36
  • 54 (a)
(Danio rerio)
Actinopterygii tmem106a 36
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
Species with no ortholog for TMEM106A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM106A Gene

Gene Tree for TMEM106A (if available)
Gene Tree for TMEM106A (if available)

Paralogs for TMEM106A Gene

Paralogs for TMEM106A Gene

Selected SIMAP similar genes for TMEM106A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TMEM106A: view

Variants for TMEM106A Gene

Sequence variations from dbSNP and Humsavar for TMEM106A Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs13539 -- 43,219,938(-) TTTGC(A/G)CTCTT utr-variant-3-prime
rs13851 -- 43,219,824(+) GTAGG(A/G)TGCAT utr-variant-3-prime
rs1138987 -- 43,219,478(+) cctgt(A/G)gtccc utr-variant-3-prime
rs2010999 -- 43,219,656(-) ctccc(A/G)ggttc utr-variant-3-prime
rs3051096 -- 43,219,750(+) aaaaa(-/AA)GATGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TMEM106A Gene

Variant ID Type Subtype PubMed ID
esv2672913 CNV Deletion 23128226
nsv908260 CNV Gain 21882294
nsv510712 CNV Loss 20534489

Relevant External Links for TMEM106A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM106A Gene

Disorders for TMEM106A Gene

No disorders were found for TMEM106A Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TMEM106A Gene

Publications for TMEM106A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  4. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  5. A de novo complete BRCA1 gene deletion identified in a Spanish woman with early bilateral breast cancer. (PMID: 21989022) Garcia-Casado Z. … Lopez-Guerrero J.A. (BMC Med. Genet. 2011) 3

Products for TMEM106A Gene

Sources for TMEM106A Gene

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