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Aliases for TMEM106A Gene

Aliases for TMEM106A Gene

  • Transmembrane Protein 106A 2 3 5

External Ids for TMEM106A Gene

Previous GeneCards Identifiers for TMEM106A Gene

  • GC17P038720
  • GC17P041363
  • GC17P037130

Summaries for TMEM106A Gene

GeneCards Summary for TMEM106A Gene

TMEM106A (Transmembrane Protein 106A) is a Protein Coding gene. An important paralog of this gene is TMEM106C.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM106A Gene

Genomics for TMEM106A Gene

Regulatory Elements for TMEM106A Gene

Enhancers for TMEM106A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMEM106A on UCSC Golden Path with GeneCards custom track

Promoters for TMEM106A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM106A on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM106A Gene

Chromosome:
17
Start:
43,211,827 bp from pter
End:
43,220,041 bp from pter
Size:
8,215 bases
Orientation:
Plus strand

Genomic View for TMEM106A Gene

Genes around TMEM106A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM106A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM106A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM106A Gene

Proteins for TMEM106A Gene

  • Protein details for TMEM106A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A25-T106A_HUMAN
    Recommended name:
    Transmembrane protein 106A
    Protein Accession:
    Q96A25
    Secondary Accessions:
    • A8K2X2
    • B7Z698

    Protein attributes for TMEM106A Gene

    Size:
    262 amino acids
    Molecular mass:
    28920 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM106A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM106A Gene

Proteomics data for TMEM106A Gene at MOPED

Post-translational modifications for TMEM106A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM106A Gene

Antibody Products

No data available for DME Specific Peptides for TMEM106A Gene

Domains & Families for TMEM106A Gene

Protein Domains for TMEM106A Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96A25

UniProtKB/Swiss-Prot:

T106A_HUMAN :
  • Belongs to the TMEM106 family.
Family:
  • Belongs to the TMEM106 family.
genes like me logo Genes that share domains with TMEM106A: view

No data available for Gene Families for TMEM106A Gene

Function for TMEM106A Gene

genes like me logo Genes that share phenotypes with TMEM106A: view

Animal Model Products

miRNA for TMEM106A Gene

miRTarBase miRNAs that target TMEM106A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM106A Gene

Localization for TMEM106A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM106A Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM106A Gene COMPARTMENTS Subcellular localization image for TMEM106A gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytosol 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for TMEM106A Gene

Pathways & Interactions for TMEM106A Gene

SuperPathways for TMEM106A Gene

No Data Available

Interacting Proteins for TMEM106A Gene

Gene Ontology (GO) - Biological Process for TMEM106A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM106A Gene

Drugs & Compounds for TMEM106A Gene

No Compound Related Data Available

Transcripts for TMEM106A Gene

Unigene Clusters for TMEM106A Gene

Transmembrane protein 106A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM106A Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9
SP1: - - - -
SP2: - - -
SP3: - -
SP4: - -
SP5:
SP6: -
SP7:

Relevant External Links for TMEM106A Gene

GeneLoc Exon Structure for
TMEM106A
ECgene alternative splicing isoforms for
TMEM106A

Expression for TMEM106A Gene

mRNA expression in normal human tissues for TMEM106A Gene

Protein differential expression in normal tissues from HIPED for TMEM106A Gene

This gene is overexpressed in Urine (67.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for TMEM106A Gene



SOURCE GeneReport for Unigene cluster for TMEM106A Gene Hs.536474

genes like me logo Genes that share expression patterns with TMEM106A: view

Protein tissue co-expression partners for TMEM106A Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM106A Gene

Orthologs for TMEM106A Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM106A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM106A 35
  • 85.44 (n)
  • 80.08 (a)
TMEM106A 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM106A 35
  • 87.69 (n)
  • 85.38 (a)
TMEM106A 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem106a 35
  • 77.44 (n)
  • 66.92 (a)
Tmem106a 16
Tmem106a 36
  • 65 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM106A 35
  • 99.37 (n)
  • 99.53 (a)
TMEM106A 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem106a 35
  • 78.08 (n)
  • 67.69 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM106A 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM106A 36
  • 54 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tmem106a 36
  • 33 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
OneToMany
Species with no ortholog for TMEM106A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM106A Gene

ENSEMBL:
Gene Tree for TMEM106A (if available)
TreeFam:
Gene Tree for TMEM106A (if available)

Paralogs for TMEM106A Gene

Paralogs for TMEM106A Gene

(2) SIMAP similar genes for TMEM106A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TMEM106A: view

Variants for TMEM106A Gene

Sequence variations from dbSNP and Humsavar for TMEM106A Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs13539 -- 43,219,938(-) TTTGC(A/G)CTCTT utr-variant-3-prime
rs13851 -- 43,219,824(+) GTAGG(A/G)TGCAT utr-variant-3-prime
rs1138987 -- 43,219,478(+) cctgt(A/G)gtccc utr-variant-3-prime
rs2010999 -- 43,219,656(-) ctccc(A/G)ggttc utr-variant-3-prime
rs3051096 -- 43,219,750(+) aaaaa(-/AA)GATGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TMEM106A Gene

Variant ID Type Subtype PubMed ID
esv2672913 CNV Deletion 23128226
nsv908260 CNV Gain 21882294
nsv510712 CNV Loss 20534489

Variation tolerance for TMEM106A Gene

Residual Variation Intolerance Score: 75.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.41; 27.80% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TMEM106A Gene

Disorders for TMEM106A Gene

Relevant External Links for TMEM106A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM106A

No disorders were found for TMEM106A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM106A Gene

Publications for TMEM106A Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Transmembrane protein 106A is silenced by promoter region hypermethylation and suppresses gastric cancer growth by inducing apoptosis. (PMID: 24975047) Xu D. … Chen Y. (J. Cell. Mol. Med. 2014) 3
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  4. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  5. A de novo complete BRCA1 gene deletion identified in a Spanish woman with early bilateral breast cancer. (PMID: 21989022) Garcia-Casado Z. … Lopez-Guerrero J.A. (BMC Med. Genet. 2011) 3

Products for TMEM106A Gene

Sources for TMEM106A Gene

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