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Aliases for TMEM106A Gene

Aliases for TMEM106A Gene

  • Transmembrane Protein 106A 2 3 5

External Ids for TMEM106A Gene

Previous GeneCards Identifiers for TMEM106A Gene

  • GC17P038720
  • GC17P041363
  • GC17P037130

Summaries for TMEM106A Gene

GeneCards Summary for TMEM106A Gene

TMEM106A (Transmembrane Protein 106A) is a Protein Coding gene. An important paralog of this gene is TMEM106B.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM106A Gene

Genomics for TMEM106A Gene

Regulatory Elements for TMEM106A Gene

Enhancers for TMEM106A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G043168 1.7 FANTOM5 ENCODE dbSUPER 22.4 -40.8 -40761 5.0 CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 SSRP1 GLIS1 NBR2 TMEM106A NBR1 ENSG00000267002
GH17G043719 1.3 FANTOM5 ENCODE 25.1 +508.9 508895 2.6 HDGF ZFP64 SIN3A DMAP1 ZNF48 ETS1 ZNF143 ZNF207 MXD4 JUNB TMEM106A SOST MEOX1 LOC105371786 DUSP3 DHX8 TMUB2 WHSC1L2P PIR44007 GC17P043726
GH17G043322 1.7 Ensembl ENCODE dbSUPER 10.9 +111.3 111336 1.6 MLX ZFP64 YBX1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 ZNF263 ENSG00000267340 ENSG00000267002 ASB16-AS1 HMGN1P29 DHX8 NBR2 ENSG00000267765 HSD17B1 CCR10 LINC00910
GH17G043366 1.7 Ensembl ENCODE dbSUPER 10.9 +156.9 156888 4.0 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 SSRP1 NBR2 DHX8 HMGN1P29 LINC00910 ASB16-AS1 ENSG00000267340 ENSG00000267002 PSME3 NBR1 MEOX1
GH17G044101 1.7 Ensembl ENCODE dbSUPER 10.8 +895.8 895828 12.5 CREB3L1 MLX ZFP64 DMAP1 YBX1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 ASB16-AS1 ASB16 NAGS G6PC3 HMGN1P29 LINC00910 C17orf53 DHX8 LSM12 RNU6-131P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM106A on UCSC Golden Path with GeneCards custom track

Promoters for TMEM106A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000094520 173 1601 ELF3 HDGF TBP FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF48 RARA

Genomic Location for TMEM106A Gene

Chromosome:
17
Start:
43,211,827 bp from pter
End:
43,220,041 bp from pter
Size:
8,215 bases
Orientation:
Plus strand

Genomic View for TMEM106A Gene

Genes around TMEM106A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM106A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM106A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM106A Gene

Proteins for TMEM106A Gene

  • Protein details for TMEM106A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A25-T106A_HUMAN
    Recommended name:
    Transmembrane protein 106A
    Protein Accession:
    Q96A25
    Secondary Accessions:
    • A8K2X2
    • B7Z698

    Protein attributes for TMEM106A Gene

    Size:
    262 amino acids
    Molecular mass:
    28920 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM106A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM106A Gene

Post-translational modifications for TMEM106A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM106A Gene

Domains & Families for TMEM106A Gene

Protein Domains for TMEM106A Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96A25

UniProtKB/Swiss-Prot:

T106A_HUMAN :
  • Belongs to the TMEM106 family.
Family:
  • Belongs to the TMEM106 family.
genes like me logo Genes that share domains with TMEM106A: view

No data available for Gene Families for TMEM106A Gene

Function for TMEM106A Gene

Gene Ontology (GO) - Molecular Function for TMEM106A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0031072 heat shock protein binding IEA --
GO:0051082 unfolded protein binding IEA --
genes like me logo Genes that share ontologies with TMEM106A: view
genes like me logo Genes that share phenotypes with TMEM106A: view

Animal Model Products

miRNA for TMEM106A Gene

miRTarBase miRNAs that target TMEM106A

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM106A Gene

Localization for TMEM106A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM106A Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM106A gene
Compartment Confidence
extracellular 5
plasma membrane 3
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TMEM106A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA,IBA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with TMEM106A: view

Pathways & Interactions for TMEM106A Gene

SuperPathways for TMEM106A Gene

No Data Available

Interacting Proteins for TMEM106A Gene

Selected Interacting proteins: Q96A25-T106A_HUMAN for TMEM106A Gene via IID

Symbol External ID(s) Details
ARF1

Gene Ontology (GO) - Biological Process for TMEM106A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM106A: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM106A Gene

Drugs & Compounds for TMEM106A Gene

No Compound Related Data Available

Transcripts for TMEM106A Gene

Unigene Clusters for TMEM106A Gene

Transmembrane protein 106A:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM106A Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9
SP1: - - - -
SP2: - - -
SP3: - -
SP4: - -
SP5:
SP6: -
SP7:

Relevant External Links for TMEM106A Gene

GeneLoc Exon Structure for
TMEM106A
ECgene alternative splicing isoforms for
TMEM106A

Expression for TMEM106A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM106A Gene

Protein differential expression in normal tissues from HIPED for TMEM106A Gene

This gene is overexpressed in Urine (67.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMEM106A Gene



Protein tissue co-expression partners for TMEM106A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM106A Gene:

TMEM106A

SOURCE GeneReport for Unigene cluster for TMEM106A Gene:

Hs.536474

Evidence on tissue expression from TISSUES for TMEM106A Gene

  • Kidney(4.4)
  • Blood(4)
genes like me logo Genes that share expression patterns with TMEM106A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM106A Gene

Orthologs for TMEM106A Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM106A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM106A 34 35
  • 99.37 (n)
dog
(Canis familiaris)
Mammalia TMEM106A 34 35
  • 87.69 (n)
cow
(Bos Taurus)
Mammalia TMEM106A 34 35
  • 85.44 (n)
rat
(Rattus norvegicus)
Mammalia Tmem106a 34
  • 78.08 (n)
mouse
(Mus musculus)
Mammalia Tmem106a 34 16 35
  • 77.44 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM106A 35
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM106A 35
  • 54 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tmem106a 35
  • 33 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 31 (a)
OneToMany
Species where no ortholog for TMEM106A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM106A Gene

ENSEMBL:
Gene Tree for TMEM106A (if available)
TreeFam:
Gene Tree for TMEM106A (if available)

Paralogs for TMEM106A Gene

Paralogs for TMEM106A Gene

(2) SIMAP similar genes for TMEM106A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TMEM106A: view

Variants for TMEM106A Gene

Sequence variations from dbSNP and Humsavar for TMEM106A Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000105420 -- 43,218,586(+) AAACC(A/G)GAAGG utr-variant-3-prime
rs1000136495 -- 43,218,897(+) TGGTT(C/T)CTAGG utr-variant-3-prime
rs1000902714 -- 43,211,013(+) ATGAG(C/T)GTGTG upstream-variant-2KB, utr-variant-3-prime
rs1001356619 -- 43,211,313(+) GAATA(C/T)GAACC upstream-variant-2KB, utr-variant-3-prime
rs1001576724 -- 43,214,263(+) CAGCA(C/G)ATGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM106A Gene

Variant ID Type Subtype PubMed ID
esv2672913 CNV deletion 23128226
esv33998 OTHER inversion 15654335
nsv1146669 OTHER inversion 26484159
nsv1160487 CNV duplication 26073780
nsv510712 CNV deletion 20534489

Variation tolerance for TMEM106A Gene

Residual Variation Intolerance Score: 75.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.41; 27.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM106A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM106A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM106A Gene

Disorders for TMEM106A Gene

Relevant External Links for TMEM106A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM106A

No disorders were found for TMEM106A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM106A Gene

Publications for TMEM106A Gene

  1. Transmembrane protein 106a activates mouse peritoneal macrophages via the MAPK and NF-I_B signaling pathways. (PMID: 26215746) Dai H. … Chen Y. (Sci Rep 2015) 2 3 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion. (PMID: 26598620) Dart A.E. … Wells C.M. (J. Cell Biol. 2015) 3 64
  5. Transmembrane protein 106A is silenced by promoter region hypermethylation and suppresses gastric cancer growth by inducing apoptosis. (PMID: 24975047) Xu D. … Chen Y. (J. Cell. Mol. Med. 2014) 3 64

Products for TMEM106A Gene

Sources for TMEM106A Gene

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