TMEM106A Gene
protein-coding GIFtS: 40
GCID: GC17P041363
|
|
transmembrane protein 106A
| |
Aliases
for TMEM106A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protein 106A1 2 | | MGC202351 |
Export aliases for TMEM106A gene to outside databasesPrevious GC identifers: GC17P038720 GC17P037130 |
Summaries
for TMEM106A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TMEM106A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMEM106A gene promoter:
AML1a MyoD Nkx2-5 AP-2gamma Nkx6-1 NRF-2 HSF2 AP-2beta AP-2alpha AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM106A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM106A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21.31 Ensembl cytogenetic band: 17q21.31 HGNC cytogenetic band: 17q21.31TMEM106A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P041363: view genomic region
(about GC identifiers)
Start:
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41,363,854 bp from pter |
End:
|
41,371,957 bp from pter |
Size:
|
8,104 bases |
Orientation:
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plus strand |
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Proteins
for TMEM106A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: T106A_HUMAN, Q96A25 (See
protein sequence)Recommended Name: Transmembrane protein 106A Size: 262 amino acids; 28920 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Secondary accessions: A8K2X2Explore the universe of human proteins at neXtProt for TMEM106A: NX_Q96A25
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96A25
TMEM106A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_659478.1
ENSEMBL proteins: ENSP00000468220 ENSP00000466820 ENSP00000439844 ENSP00000439835 ENSP00000330774
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- | | GO:0016021 | integral to membrane |
IEA | -- |
TMEM106A for ontologies About GeneDecksing
TMEM106A Antibody Products:
Assay Products for TMEM106A: |
Protein
Domains /
Families
for TMEM106A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMEM106A for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96A25ProtoNet protein and cluster: Q96A25 UniProtKB/Swiss-Prot: T106A_HUMAN, Q96A25Similarity: Belongs to the TMEM106 family |
Function
for TMEM106A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM106A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM106A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TMEM106A (NM_145041) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM106A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM106A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM106A |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
TMEM106A for ontologies About GeneDecksing
|
Pathways & Interactions
for TMEM106A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM106A
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for TMEM106A (ENSP000003307744) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
TMEM106A for ontologies About GeneDecksing
|
Drugs & Compounds
for TMEM106A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM106A
Search CenterWatch for drugs/clinical trials and news about TMEM106A / T106A
|
Transcripts
for TMEM106A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMEM106A gene: NM_145041.1 Unigene Cluster for TMEM106A: Transmembrane protein 106A Hs.536474 [show with all ESTs]Unigene Representative Sequence: U257508 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000588693 ENST00000592649 ENST00000588659 ENST00000541594 ENST00000536052
ENST00000331615(uc002idn.1 uc010why.1 uc010cze.1 uc010whz.1)
ENST00000592564 ENST00000586685
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM106A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM106A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TMEM106A (NM_145041) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM106A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM106A |
Additional cDNA sequence: AK056132.1 AK290387.1 AK299974.1 AK301571.1 BC012139.2 BC146974.1 BC146976.1 BC147023.1 BC157892.1 U25750.1 9 DOTS entries: DT.91839077 DT.95362516 DT.91862610 DT.441451 DT.97790020 DT.120910681 DT.40120018 DT.40197359 DT.120910684 24/62 AceView cDNA sequences (see all 62): NM_145041 BP357704 AI127782 CF594005 AK056132 AW571869 AI572375 CB990540 CD370798 BI828634 BU752246 CO248274 BC012139 BQ013276 CD365427 BX382692 AA593628 CF994987 CB958390 BG391350 AI865750 BF893724 AI872282 BG326098
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM106A (see all 7) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 |
|---|
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| SP1: | | | | | - | | - | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TMEM106A
|
Expression
for TMEM106A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM106A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAGTGGACA
About this image
See TMEM106A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM106A
SOURCE GeneReport for Unigene cluster: Hs.536474
SABiosciences Custom PCR Arrays for TMEM106A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM106A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM106A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM106A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM106A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM106A |
Orthologs
for TMEM106A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TMEM106A gene from 2/12 species (see all 12) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
TMEM106A6 |
-- |
56(a) |
1 ↔ 1 |
6(62889805-62901001) |
zebrafish
(Danio rerio) |
Actinopterygii |
BC050177.12 |
-- |
73.97(n) |
|
BC050177.1 |
ENSEMBL Gene Tree for TMEM106A (if available)
TreeFam Gene Tree for TMEM106A (if available) |
Paralogs
for TMEM106A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TMEM106A gene
- TMEM106C2 TMEM106B2
2 SIMAP similar genes for TMEM106A using alignment to 4 protein entries: T106A_HUMAN (see all proteins):TMEM106C TMEM106B
TMEM106A for paralogs About GeneDecksing
|
Genomic Variants
for TMEM106A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM106A (41363854 - 41371957 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TMEM106A: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM106A |
|
Disorders
/ Diseases
for TMEM106A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TMEM106A for disorders About GeneDecksing
2  diseases for TMEM106A: About MalaCardsbilateral breast cancer breast cancer
Export disorders for TMEM106A gene to outside databases
|
Publications
for TMEM106A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM106A gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM106A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A de novo complete BRCA1 gene deletion identified in a Spanish woman with early bilateral breast cancer. (PubMed id 21989022)1 Garcia-Casado Z....Lopez-Guerrero J.A. (2011)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for TMEM106A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMEM106A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMEM106A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM106A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM106A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMEM106A gene:
Search GeneIP for patents involving TMEM106A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM106A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TMEM106A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM106A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM106A | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMEM106A | | OriGene 3'-UTR Clone for TMEM106A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM106A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM106A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TMEM106A | | OriGene Custom Protein Services for TMEM106A | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM106A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM106A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM106A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM106A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM106A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM106A |
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 | | | TMEM106A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM106A |
|  |  |  | | | | Search ThermoFisher Antibodies for TMEM106A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM106A |
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