Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMEM105 Gene

Aliases for TMEM105 Gene

  • Transmembrane Protein 105 2 3

External Ids for TMEM105 Gene

Previous GeneCards Identifiers for TMEM105 Gene

  • GC17M076900
  • GC17M079285
  • GC17M074723

Summaries for TMEM105 Gene

GeneCards Summary for TMEM105 Gene

TMEM105 (Transmembrane Protein 105) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM105 Gene

Genomics for TMEM105 Gene

Regulatory Elements for TMEM105 Gene

Genomic Location for TMEM105 Gene

81,311,270 bp from pter
81,330,674 bp from pter
19,405 bases
Minus strand

Genomic View for TMEM105 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM105 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM105 Gene

Proteins for TMEM105 Gene

  • Protein details for TMEM105 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 105
    Protein Accession:
    Secondary Accessions:

    Protein attributes for TMEM105 Gene

    129 amino acids
    Molecular mass:
    13990 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM105 Gene

Proteomics data for TMEM105 Gene at MOPED

Post-translational modifications for TMEM105 Gene

No Post-translational modifications

Other Protein References for TMEM105 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM105 Gene

Domains for TMEM105 Gene

Protein Domains for TMEM105 Gene


Suggested Antigen Peptide Sequences for TMEM105 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM105: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM105 Gene

Function for TMEM105 Gene

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM105

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TMEM105 Gene

Localization for TMEM105 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM105 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMEM105 Gene COMPARTMENTS Subcellular localization image for TMEM105 gene
Compartment Confidence
cytosol 2
mitochondrion 2
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMEM105 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM105: view

Pathways for TMEM105 Gene

SuperPathways for TMEM105 Gene

No Data Available

Interacting Proteins for TMEM105 Gene

Gene Ontology (GO) - Biological Process for TMEM105 Gene


No data available for Pathways by source for TMEM105 Gene

Transcripts for TMEM105 Gene

mRNA/cDNA for TMEM105 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM105 Gene

Transmembrane protein 105:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM105

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM105 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c
SP1: -
SP2: - -

Relevant External Links for TMEM105 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM105 Gene

mRNA expression in normal human tissues for TMEM105 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM105 Gene

This gene is overexpressed in Liver (12.2), Bladder (5.6), and Kidney - Cortex (5.0).

Protein differential expression in normal tissues for TMEM105 Gene

This gene is overexpressed in Serum (69.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TMEM105 Gene

SOURCE GeneReport for Unigene cluster for TMEM105 Gene Hs.364191

genes like me logo Genes that share expressions with TMEM105: view

Expression partners for TMEM105 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TMEM105 Gene

Orthologs for TMEM105 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for TMEM105 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM105 35
  • 99.22 (n)
  • 98.45 (a)
TMEM105 36
  • 98 (a)
Species with no ortholog for TMEM105:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM105 Gene

Gene Tree for TMEM105 (if available)
Gene Tree for TMEM105 (if available)

Paralogs for TMEM105 Gene

No data available for Paralogs for TMEM105 Gene

Variants for TMEM105 Gene

Sequence variations from dbSNP and Humsavar for TMEM105 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs879320 -- 81,330,425(+) CAGCA(C/T)GGGAA utr-variant-5-prime
rs1986430 -- 81,326,867(-) ctggg(C/G)gtggt intron-variant
rs2618171 -- 81,331,300(-) ACCCA(G/T)GGACA upstream-variant-2KB
rs2618172 -- 81,330,013(-) GCCCA(C/G)AGAGC intron-variant
rs2659001 -- 81,319,388(+) ATACT(C/T)TATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM105 Gene

Variant ID Type Subtype PubMed ID
esv26223 CNV Gain+Loss 19812545
nsv828128 CNV Loss 20364138
nsv909000 CNV Loss 21882294
dgv3308n71 CNV Loss 21882294
nsv470619 CNV Loss 18288195
dgv3310n71 CNV Loss 21882294
dgv3316n71 CNV Loss 21882294
nsv909052 CNV Loss 21882294
dgv1003e1 CNV Complex 17122850
nsv428351 CNV Gain 18775914
dgv3318n71 CNV Loss 21882294
dgv3320n71 CNV Loss 21882294
dgv3322n71 CNV Loss 21882294
dgv3323n71 CNV Loss 21882294
nsv909076 CNV Loss 21882294
dgv3324n71 CNV Loss 21882294
nsv909079 CNV Gain 21882294
dgv3325n71 CNV Loss 21882294
esv2660823 CNV Deletion 23128226
dgv3326n71 CNV Loss 21882294
nsv9598 CNV Loss 18304495
nsv909085 CNV Loss 21882294

Relevant External Links for TMEM105 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM105 Gene

Disorders for TMEM105 Gene

Relevant External Links for TMEM105

Genetic Association Database (GAD)

No disorders were found for TMEM105 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for TMEM105 Gene

Publications for TMEM105 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for TMEM105 Gene

Sources for TMEM105 Gene

Back to Top