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Aliases for TMEM105 Gene

Aliases for TMEM105 Gene

  • Transmembrane Protein 105 2 3 5

External Ids for TMEM105 Gene

Previous GeneCards Identifiers for TMEM105 Gene

  • GC17M076900
  • GC17M079285
  • GC17M074723

Summaries for TMEM105 Gene

GeneCards Summary for TMEM105 Gene

TMEM105 (Transmembrane Protein 105) is a Protein Coding gene.

Additional gene information for TMEM105 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM105 Gene

Genomics for TMEM105 Gene

GeneHancer (GH) Regulatory Elements for TMEM105 Gene

Promoters and enhancers for TMEM105 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I081325 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 618 +1.6 1639 6.5 PKNOX1 FOXA2 CLOCK NEUROD1 SIN3A ZBTB7B BRCA1 YY1 ZNF121 GLIS2 TMEM105 LOC100294362 CCDC57 ENDOV CEP131 GPS1 ENSG00000265678 SLC38A10 ARL16 ENSG00000262877
GH17I081315 Promoter/Enhancer 0.8 EPDnew dbSUPER 550.4 +14.7 14743 0.1 MNT TMEM105 LINC00482
GH17I081336 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 26.3 -11.3 -11269 10.8 PKNOX1 SMAD1 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 GC17P081340 GC17M081340 FAAP100 RFNG TMEM105 DUS1L HGS ENSG00000265678 LINC00482 TEPSIN
GH17I081384 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.2 -65.4 -65430 22.4 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF263 BAHCC1 ENSG00000279692 ENSG00000262877 CEP131 GPS1 HGS ENSG00000260011 FAAP100 ENSG00000260369 ENSG00000265678
GH17I081284 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 17.8 +43.9 43910 3.8 ATF1 YY1 ZNF766 ZNF207 ZNF143 ATF7 ZNF592 MBD2 MEF2D GMEB1 SLC38A10 TMEM105 CEP131 LOC100294362 CCDC57 ENDOV LINC00482 GPS1 ENSG00000265678 ARL16
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM105 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM105 gene promoter:

Genomic Locations for TMEM105 Gene

Genomic Locations for TMEM105 Gene
chr17:81,305,814-81,330,674
(GRCh38/hg38)
Size:
24,861 bases
Orientation:
Minus strand
chr17:79,285,070-79,304,474
(GRCh37/hg19)

Genomic View for TMEM105 Gene

Genes around TMEM105 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM105 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM105 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM105 Gene

Proteins for TMEM105 Gene

  • Protein details for TMEM105 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N8V8-TM105_HUMAN
    Recommended name:
    Transmembrane protein 105
    Protein Accession:
    Q8N8V8

    Protein attributes for TMEM105 Gene

    Size:
    129 amino acids
    Molecular mass:
    13990 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM105 Gene

Post-translational modifications for TMEM105 Gene

No Post-translational modifications

Other Protein References for TMEM105 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM105 Gene

Domains & Families for TMEM105 Gene

Gene Families for TMEM105 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMEM105 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TMEM105 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM105: view

No data available for UniProtKB/Swiss-Prot for TMEM105 Gene

Function for TMEM105 Gene

Phenotypes From GWAS Catalog for TMEM105 Gene

Phenotypes for TMEM105 Gene

GenomeRNAi human phenotypes for TMEM105:
genes like me logo Genes that share phenotypes with TMEM105: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM105 Gene

Localization for TMEM105 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM105 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM105 gene
Compartment Confidence
mitochondrion 2
cytosol 2
extracellular 1
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TMEM105 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM105: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM105 Gene

Pathways & Interactions for TMEM105 Gene

SuperPathways for TMEM105 Gene

No Data Available

Interacting Proteins for TMEM105 Gene

Gene Ontology (GO) - Biological Process for TMEM105 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM105 Gene

Drugs & Compounds for TMEM105 Gene

No Compound Related Data Available

Transcripts for TMEM105 Gene

mRNA/cDNA for TMEM105 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM105 Gene

Transmembrane protein 105:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM105 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c
SP1: -
SP2: - -
SP3:

Relevant External Links for TMEM105 Gene

GeneLoc Exon Structure for
TMEM105
ECgene alternative splicing isoforms for
TMEM105

Expression for TMEM105 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM105 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM105 Gene

This gene is overexpressed in Liver (x12.2), Bladder (x5.6), and Kidney - Cortex (x5.0).

Protein differential expression in normal tissues from HIPED for TMEM105 Gene

This gene is overexpressed in Serum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM105 Gene



Protein tissue co-expression partners for TMEM105 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM105 Gene:

TMEM105

SOURCE GeneReport for Unigene cluster for TMEM105 Gene:

Hs.364191

Evidence on tissue expression from TISSUES for TMEM105 Gene

  • Liver(4)
genes like me logo Genes that share expression patterns with TMEM105: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM105 Gene

Orthologs for TMEM105 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for TMEM105 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM105 33 34
  • 99.22 (n)
Species where no ortholog for TMEM105 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM105 Gene

ENSEMBL:
Gene Tree for TMEM105 (if available)
TreeFam:
Gene Tree for TMEM105 (if available)

Paralogs for TMEM105 Gene

No data available for Paralogs for TMEM105 Gene

Variants for TMEM105 Gene

Sequence variations from dbSNP and Humsavar for TMEM105 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000155676 -- 81,324,707(-) C/T intron_variant
rs1000155804 -- 81,332,674(-) T/A upstream_transcript_variant
rs1000265185 -- 81,319,939(-) C/G intron_variant
rs1000328238 -- 81,314,939(-) G/T intron_variant
rs1000378882 -- 81,311,071(-) C/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM105 Gene

Variant ID Type Subtype PubMed ID
esv26223 CNV gain+loss 19812545
esv2660823 CNV deletion 23128226
esv2758707 CNV gain 17122850
esv3641395 CNV loss 21293372
esv3641396 CNV loss 21293372
nsv1160499 CNV deletion 26073780
nsv428351 CNV gain 18775914
nsv470619 CNV loss 18288195
nsv479813 CNV novel sequence insertion 20440878
nsv576173 CNV loss 21841781
nsv576174 CNV loss 21841781
nsv828128 CNV loss 20364138
nsv952389 CNV deletion 24416366
nsv9598 CNV loss 18304495

Variation tolerance for TMEM105 Gene

Residual Variation Intolerance Score: 83.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.20; 52.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM105 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM105

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM105 Gene

Disorders for TMEM105 Gene

Additional Disease Information for TMEM105

No disorders were found for TMEM105 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM105 Gene

Publications for TMEM105 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for TMEM105 Gene

Sources for TMEM105 Gene

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