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Aliases for TMEM105 Gene

Aliases for TMEM105 Gene

  • Transmembrane Protein 105 2 3 5

External Ids for TMEM105 Gene

Previous GeneCards Identifiers for TMEM105 Gene

  • GC17M076900
  • GC17M079285
  • GC17M074723

Summaries for TMEM105 Gene

GeneCards Summary for TMEM105 Gene

TMEM105 (Transmembrane Protein 105) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM105 Gene

Genomics for TMEM105 Gene

Regulatory Elements for TMEM105 Gene

Promoters for TMEM105 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM105 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM105 Gene

81,305,814 bp from pter
81,330,674 bp from pter
24,861 bases
Minus strand

Genomic View for TMEM105 Gene

Genes around TMEM105 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM105 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM105 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM105 Gene

Proteins for TMEM105 Gene

  • Protein details for TMEM105 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 105
    Protein Accession:

    Protein attributes for TMEM105 Gene

    129 amino acids
    Molecular mass:
    13990 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM105 Gene

Proteomics data for TMEM105 Gene at MOPED

Post-translational modifications for TMEM105 Gene

No Post-translational modifications

Other Protein References for TMEM105 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM105 Gene

Domains & Families for TMEM105 Gene

Protein Domains for TMEM105 Gene


Suggested Antigen Peptide Sequences for TMEM105 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM105: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM105 Gene

Function for TMEM105 Gene

Phenotypes for TMEM105 Gene

GenomeRNAi human phenotypes for TMEM105:
genes like me logo Genes that share phenotypes with TMEM105: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM105 Gene

Localization for TMEM105 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM105 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMEM105 Gene COMPARTMENTS Subcellular localization image for TMEM105 gene
Compartment Confidence
cytosol 2
mitochondrion 2
extracellular 1
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for TMEM105 Gene

Pathways & Interactions for TMEM105 Gene

SuperPathways for TMEM105 Gene

No Data Available

Interacting Proteins for TMEM105 Gene

Gene Ontology (GO) - Biological Process for TMEM105 Gene


No data available for Pathways by source and SIGNOR curated interactions for TMEM105 Gene

Drugs & Compounds for TMEM105 Gene

No Compound Related Data Available

Transcripts for TMEM105 Gene

mRNA/cDNA for TMEM105 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM105 Gene

Transmembrane protein 105:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM105 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c
SP1: -
SP2: - -

Relevant External Links for TMEM105 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM105 Gene

mRNA expression in normal human tissues for TMEM105 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM105 Gene

This gene is overexpressed in Liver (x12.2), Bladder (x5.6), and Kidney - Cortex (x5.0).

Protein differential expression in normal tissues from HIPED for TMEM105 Gene

This gene is overexpressed in Serum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM105 Gene

SOURCE GeneReport for Unigene cluster for TMEM105 Gene Hs.364191

genes like me logo Genes that share expression patterns with TMEM105: view

Protein tissue co-expression partners for TMEM105 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TMEM105 Gene

Orthologs for TMEM105 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for TMEM105 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM105 35
  • 99.22 (n)
  • 98.45 (a)
TMEM105 36
  • 98 (a)
Species with no ortholog for TMEM105:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM105 Gene

Gene Tree for TMEM105 (if available)
Gene Tree for TMEM105 (if available)

Paralogs for TMEM105 Gene

No data available for Paralogs for TMEM105 Gene

Variants for TMEM105 Gene

Sequence variations from dbSNP and Humsavar for TMEM105 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs9916085 - 81,313,677(+) ACCCC(A/G)GCCCC reference, missense
rs879320 -- 81,330,425(+) CAGCA(C/T)GGGAA utr-variant-5-prime
rs1986430 -- 81,326,867(-) ctggg(C/G)gtggt intron-variant
rs2864474 -- 81,328,349(-) GCCCC(A/G)CTGCG intron-variant
rs2864475 -- 81,328,324(-) GCTGA(C/T)GCACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM105 Gene

Variant ID Type Subtype PubMed ID
esv26223 CNV Gain+Loss 19812545
nsv828128 CNV Loss 20364138
nsv909000 CNV Loss 21882294
dgv3308n71 CNV Loss 21882294
nsv470619 CNV Loss 18288195
dgv3310n71 CNV Loss 21882294
dgv3316n71 CNV Loss 21882294
nsv909052 CNV Loss 21882294
dgv1003e1 CNV Complex 17122850
nsv428351 CNV Gain 18775914
dgv3318n71 CNV Loss 21882294
dgv3320n71 CNV Loss 21882294
dgv3322n71 CNV Loss 21882294
dgv3323n71 CNV Loss 21882294
nsv909076 CNV Loss 21882294
dgv3324n71 CNV Loss 21882294
nsv909079 CNV Gain 21882294
dgv3325n71 CNV Loss 21882294
esv2660823 CNV Deletion 23128226
dgv3326n71 CNV Loss 21882294
nsv9598 CNV Loss 18304495
nsv909085 CNV Loss 21882294

Variation tolerance for TMEM105 Gene

Residual Variation Intolerance Score: 83.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.20; 52.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM105 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM105 Gene

Disorders for TMEM105 Gene

Relevant External Links for TMEM105

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMEM105 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM105 Gene

Publications for TMEM105 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67

Products for TMEM105 Gene

Sources for TMEM105 Gene

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