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Aliases for TMEM104 Gene

Aliases for TMEM104 Gene

  • Transmembrane Protein 104 2 3 5

External Ids for TMEM104 Gene

Previous GeneCards Identifiers for TMEM104 Gene

  • GC17P070285
  • GC17P072772
  • GC17P068182

Summaries for TMEM104 Gene

GeneCards Summary for TMEM104 Gene

TMEM104 (Transmembrane Protein 104) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM104 Gene

Genomics for TMEM104 Gene

Regulatory Elements for TMEM104 Gene

Enhancers for TMEM104 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F074635 1.7 FANTOM5 Ensembl ENCODE 16.7 -137.3 -137258 8.3 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF48 SLC30A9 SP5 NFYC MXD4 CD300E CD300C CD300LB RAB37 TMEM104 CD300LF CD300LD ENSG00000236770 MIR3615 SLC9A3R1
GH17F074687 1.7 FANTOM5 Ensembl ENCODE 14.5 -87.1 -87082 4.0 HDGF ARID4B SIN3A FEZF1 FOS SP5 MXD4 REST TBX21 KAT8 CD300LF CD300E TMEM104 CD300LD SUMO2 CD300C CD300LB FADS6 NAT9 GRIN2C
GH17F074568 1.6 FANTOM5 Ensembl ENCODE 7.9 -207.3 -207283 2.4 TBP ARNT YBX1 GLI4 FOS EGR2 YY2 CEBPB ZNF645 SP1 LOC100130520 CD300E CD300C NAT9 NUP85 CD300LB NT5C ENSG00000266765 LINC02092 ENSG00000265927
GH17F074778 1.4 FANTOM5 ENCODE 9 +3.3 3321 3.5 PKNOX1 ARID4B ZNF48 ZNF143 FOS MXD4 MIER2 REST KAT8 MIER3 CD300LF RAB37 SLC9A3R1 MIR3615 GRIN2C TMEM104 CD300LB CD300A CD300C GGA3
GH17F074785 1.4 FANTOM5 Ensembl ENCODE 9 +9.9 9851 1.9 TBP ELF3 SOX13 DRAP1 CTCF SAP130 ARID4B DMAP1 ZNF644 RAD21 RAB37 CD300E SLC9A3R1 MIR3615 GRIN2C FADS6 CD300LB TMEM104 CD300LF CD300C
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM104 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM104 Gene

Chromosome:
17
Start:
74,776,483 bp from pter
End:
74,839,783 bp from pter
Size:
63,301 bases
Orientation:
Plus strand

Genomic View for TMEM104 Gene

Genes around TMEM104 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM104 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM104 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM104 Gene

Proteins for TMEM104 Gene

  • Protein details for TMEM104 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NE00-TM104_HUMAN
    Recommended name:
    Transmembrane protein 104
    Protein Accession:
    Q8NE00
    Secondary Accessions:
    • Q8TEU1
    • Q9NT56
    • Q9NXH1

    Protein attributes for TMEM104 Gene

    Size:
    496 amino acids
    Molecular mass:
    55679 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB84855.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM104 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM104 Gene

Post-translational modifications for TMEM104 Gene

No data available for DME Specific Peptides for TMEM104 Gene

Domains & Families for TMEM104 Gene

Protein Domains for TMEM104 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM104 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NE00

UniProtKB/Swiss-Prot:

TM104_HUMAN :
  • Belongs to the TMEM104 family.
Family:
  • Belongs to the TMEM104 family.
genes like me logo Genes that share domains with TMEM104: view

No data available for Gene Families for TMEM104 Gene

Function for TMEM104 Gene

Gene Ontology (GO) - Molecular Function for TMEM104 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM104: view

Phenotypes for TMEM104 Gene

genes like me logo Genes that share phenotypes with TMEM104: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM104

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM104 Gene

Localization for TMEM104 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM104 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM104 gene
Compartment Confidence
plasma membrane 3
nucleus 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for TMEM104 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM104: view

Pathways & Interactions for TMEM104 Gene

SuperPathways for TMEM104 Gene

No Data Available

Interacting Proteins for TMEM104 Gene

Gene Ontology (GO) - Biological Process for TMEM104 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM104: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM104 Gene

Transcripts for TMEM104 Gene

Unigene Clusters for TMEM104 Gene

Transmembrane protein 104:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM104 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12
SP1: - - - - -
SP2: -
SP3: -
SP4:
SP5:

Relevant External Links for TMEM104 Gene

GeneLoc Exon Structure for
TMEM104
ECgene alternative splicing isoforms for
TMEM104

Expression for TMEM104 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM104 Gene

Protein differential expression in normal tissues from HIPED for TMEM104 Gene

This gene is overexpressed in Adrenal (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM104 Gene



Protein tissue co-expression partners for TMEM104 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM104 Gene:

TMEM104

SOURCE GeneReport for Unigene cluster for TMEM104 Gene:

Hs.370262
genes like me logo Genes that share expression patterns with TMEM104: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM104 Gene

Orthologs for TMEM104 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM104 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM104 34 35
  • 99.42 (n)
dog
(Canis familiaris)
Mammalia TMEM104 34 35
  • 90.66 (n)
rat
(Rattus norvegicus)
Mammalia Tmem104 34
  • 87.9 (n)
mouse
(Mus musculus)
Mammalia Tmem104 34 16 35
  • 87.77 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM104 35
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM104 35
  • 78 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM104 35
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM104 34 35
  • 77.51 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM104 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem104 34
  • 72.17 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem104 34 35
  • 71.69 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002099 34
  • 56.37 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5262 34 35
  • 51.36 (n)
worm
(Caenorhabditis elegans)
Secernentea C03A3.2 34 35
  • 49.07 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 54 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.897 34
Species where no ortholog for TMEM104 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM104 Gene

ENSEMBL:
Gene Tree for TMEM104 (if available)
TreeFam:
Gene Tree for TMEM104 (if available)

Paralogs for TMEM104 Gene

(1) SIMAP similar genes for TMEM104 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TMEM104: view

No data available for Paralogs for TMEM104 Gene

Variants for TMEM104 Gene

Sequence variations from dbSNP and Humsavar for TMEM104 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs10512600 -- 74,816,840(-) ATGAC(A/G)TTATA intron-variant
rs10512601 -- 74,805,567(-) GCTCT(C/G)TTGAA intron-variant
rs10512602 -- 74,778,036(-) CAAAG(C/T)GGTTT intron-variant, upstream-variant-2KB
rs10569751 -- 74,778,649(+) AGTCT(-/T)TTTTT intron-variant
rs1058731 -- 74,838,281(+) TCTAT(A/C)ATTGC intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TMEM104 Gene

Variant ID Type Subtype PubMed ID
nsv952367 CNV deletion 24416366
nsv833540 CNV loss 17160897
nsv576025 CNV loss 21841781
nsv518292 CNV loss 19592680
nsv457907 CNV loss 19166990
esv8400 CNV gain 19470904
esv3554778 CNV deletion 23714750
esv2716234 CNV deletion 23290073
esv2716233 CNV deletion 23290073
esv1113079 CNV insertion 17803354
esv1000943 CNV insertion 20482838

Variation tolerance for TMEM104 Gene

Residual Variation Intolerance Score: 83.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.12; 51.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM104 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM104

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM104 Gene

Disorders for TMEM104 Gene

Relevant External Links for TMEM104

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM104

No disorders were found for TMEM104 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM104 Gene

Publications for TMEM104 Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt K.T. … Blagoev B. (Sci. Signal. 2011) 4 64

Products for TMEM104 Gene

Sources for TMEM104 Gene

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