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Aliases for TMEM104 Gene

Aliases for TMEM104 Gene

  • Transmembrane Protein 104 2 3 5

External Ids for TMEM104 Gene

Previous GeneCards Identifiers for TMEM104 Gene

  • GC17P070285
  • GC17P072772
  • GC17P068182

Summaries for TMEM104 Gene

GeneCards Summary for TMEM104 Gene

TMEM104 (Transmembrane Protein 104) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM104 Gene

Genomics for TMEM104 Gene

Regulatory Elements for TMEM104 Gene

Genomic Location for TMEM104 Gene

Chromosome:
17
Start:
74,776,483 bp from pter
End:
74,839,783 bp from pter
Size:
63,301 bases
Orientation:
Plus strand

Genomic View for TMEM104 Gene

Genes around TMEM104 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM104 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM104 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM104 Gene

Proteins for TMEM104 Gene

  • Protein details for TMEM104 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NE00-TM104_HUMAN
    Recommended name:
    Transmembrane protein 104
    Protein Accession:
    Q8NE00
    Secondary Accessions:
    • Q8TEU1
    • Q9NT56
    • Q9NXH1

    Protein attributes for TMEM104 Gene

    Size:
    496 amino acids
    Molecular mass:
    55679 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB84855.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM104 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM104 Gene

Proteomics data for TMEM104 Gene at MOPED

Post-translational modifications for TMEM104 Gene

Other Protein References for TMEM104 Gene

No data available for DME Specific Peptides for TMEM104 Gene

Domains & Families for TMEM104 Gene

Protein Domains for TMEM104 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM104 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NE00

UniProtKB/Swiss-Prot:

TM104_HUMAN :
  • Belongs to the TMEM104 family.
Family:
  • Belongs to the TMEM104 family.
genes like me logo Genes that share domains with TMEM104: view

No data available for Gene Families for TMEM104 Gene

Function for TMEM104 Gene

Phenotypes for TMEM104 Gene

genes like me logo Genes that share phenotypes with TMEM104: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM104 Gene

Localization for TMEM104 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM104 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM104 Gene COMPARTMENTS Subcellular localization image for TMEM104 gene
Compartment Confidence
plasma membrane 3
golgi apparatus 2
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for TMEM104 Gene

Pathways & Interactions for TMEM104 Gene

SuperPathways for TMEM104 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM104 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM104 Gene

Drugs & Compounds for TMEM104 Gene

No Compound Related Data Available

Transcripts for TMEM104 Gene

Unigene Clusters for TMEM104 Gene

Transmembrane protein 104:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM104 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12
SP1: - - - - -
SP2: -
SP3: -
SP4:
SP5:

Relevant External Links for TMEM104 Gene

GeneLoc Exon Structure for
TMEM104
ECgene alternative splicing isoforms for
TMEM104

Expression for TMEM104 Gene

mRNA expression in normal human tissues for TMEM104 Gene

Protein differential expression in normal tissues from HIPED for TMEM104 Gene

This gene is overexpressed in Adrenal (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM104 Gene



SOURCE GeneReport for Unigene cluster for TMEM104 Gene Hs.370262

genes like me logo Genes that share expression patterns with TMEM104: view

Protein tissue co-expression partners for TMEM104 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM104 Gene

Orthologs for TMEM104 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM104 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia TMEM104 35
  • 90.66 (n)
  • 92.94 (a)
TMEM104 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem104 35
  • 87.77 (n)
  • 89.72 (a)
Tmem104 16
Tmem104 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM104 35
  • 99.42 (n)
  • 99.34 (a)
TMEM104 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem104 35
  • 87.9 (n)
  • 89.11 (a)
cow
(Bos Taurus)
Mammalia TMEM104 36
  • 59 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM104 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM104 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM104 35
  • 77.51 (n)
  • 82.02 (a)
TMEM104 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM104 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem104 35
  • 72.17 (n)
  • 74.95 (a)
zebrafish
(Danio rerio)
Actinopterygii tmem104 35
  • 71.69 (n)
  • 74.75 (a)
tmem104 36
  • 74 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002099 35
  • 56.37 (n)
  • 47.69 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5262 35
  • 51.36 (n)
  • 44.89 (a)
CG5262 36
  • 42 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C03A3.2 35
  • 49.07 (n)
  • 42.06 (a)
C03A3.2 36
  • 37 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.897 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
OneToOne
Species with no ortholog for TMEM104:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM104 Gene

ENSEMBL:
Gene Tree for TMEM104 (if available)
TreeFam:
Gene Tree for TMEM104 (if available)

Paralogs for TMEM104 Gene

(1) SIMAP similar genes for TMEM104 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TMEM104: view

No data available for Paralogs for TMEM104 Gene

Variants for TMEM104 Gene

Sequence variations from dbSNP and Humsavar for TMEM104 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs2016126 - 74,788,793(-) GGTCA(C/T)GAAGC reference, missense
rs3803784 - 74,836,511(-) GAAGG(C/T)GGGGA intron-variant, reference, missense
rs872640 -- 74,797,594(-) GACAA(C/T)GCCAA intron-variant
rs1058731 -- 74,838,281(+) TCTAT(A/C)ATTGC intron-variant, utr-variant-3-prime
rs939537 -- 74,834,293(-) CAAAT(C/T)GTCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM104 Gene

Variant ID Type Subtype PubMed ID
nsv908743 CNV Loss 21882294
nsv457907 CNV Loss 19166990
esv1000943 CNV Insertion 20482838
esv1113079 CNV Insertion 17803354
esv2716233 CNV Deletion 23290073
esv8400 CNV Gain 19470904
nsv518292 CNV Loss 19592680
esv2716234 CNV Deletion 23290073
nsv908744 CNV Loss 21882294
dgv3253n71 CNV Loss 21882294
nsv833540 CNV Loss 17160897

Variation tolerance for TMEM104 Gene

Residual Variation Intolerance Score: 83.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.12; 51.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM104 Gene

HapMap Linkage Disequilibrium report
TMEM104

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM104 Gene

Disorders for TMEM104 Gene

Relevant External Links for TMEM104

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM104

No disorders were found for TMEM104 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM104 Gene

Publications for TMEM104 Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Defining the human deubiquitinating enzyme interaction landscape. (PMID: 19615732) Sowa M.E. … Harper J.W. (Cell 2009) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for TMEM104 Gene

Sources for TMEM104 Gene

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