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Aliases for TMEM104 Gene

Aliases for TMEM104 Gene

  • Transmembrane Protein 104 2 3

External Ids for TMEM104 Gene

Previous GeneCards Identifiers for TMEM104 Gene

  • GC17P070285
  • GC17P072772
  • GC17P068182

Summaries for TMEM104 Gene

GeneCards Summary for TMEM104 Gene

TMEM104 (Transmembrane Protein 104) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM104 Gene

Genomics for TMEM104 Gene

Regulatory Elements for TMEM104 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMEM104 Gene

Start:
74,776,483 bp from pter
End:
74,839,783 bp from pter
Size:
63,301 bases
Orientation:
Plus strand

Genomic View for TMEM104 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM104 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM104 Gene

Proteins for TMEM104 Gene

  • Protein details for TMEM104 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NE00-TM104_HUMAN
    Recommended name:
    Transmembrane protein 104
    Protein Accession:
    Q8NE00
    Secondary Accessions:
    • Q8TEU1
    • Q9NT56
    • Q9NXH1

    Protein attributes for TMEM104 Gene

    Size:
    496 amino acids
    Molecular mass:
    55679 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB84855.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM104 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM104 Gene

Proteomics data for TMEM104 Gene at MOPED

Post-translational modifications for TMEM104 Gene

Other Protein References for TMEM104 Gene

No data available for DME Specific Peptides for TMEM104 Gene

Domains for TMEM104 Gene

Protein Domains for TMEM104 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM104 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NE00

UniProtKB/Swiss-Prot:

TM104_HUMAN :
  • Q8NE00
Family:
  • Belongs to the TMEM104 family.
genes like me logo Genes that share domains with TMEM104: view

No data available for Gene Families for TMEM104 Gene

Function for TMEM104 Gene

Gene Ontology (GO) - Molecular Function for TMEM104 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM104: view

Animal Model Products

CRISPR Products

miRNA for TMEM104 Gene

miRTarBase miRNAs that target TMEM104

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM104

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM104 Gene

Localization for TMEM104 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM104 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM104 Gene COMPARTMENTS Subcellular localization image for TMEM104 gene
Compartment Confidence
plasma membrane 3
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TMEM104 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM104: view

Pathways for TMEM104 Gene

SuperPathways for TMEM104 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM104 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM104: view

No data available for Pathways by source for TMEM104 Gene

Transcripts for TMEM104 Gene

Unigene Clusters for TMEM104 Gene

Transmembrane protein 104:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM104

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TMEM104

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM104 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12
SP1: - - - - -
SP2: -
SP3: -
SP4:
SP5:

Relevant External Links for TMEM104 Gene

GeneLoc Exon Structure for
TMEM104
ECgene alternative splicing isoforms for
TMEM104

Expression for TMEM104 Gene

mRNA expression in normal human tissues for TMEM104 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM104 Gene

SOURCE GeneReport for Unigene cluster for TMEM104 Gene Hs.370262

genes like me logo Genes that share expressions with TMEM104: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM104 Gene

Orthologs for TMEM104 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM104 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM104 35
  • 99.42 (n)
  • 99.34 (a)
TMEM104 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM104 36
  • 59 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM104 35
  • 90.66 (n)
  • 92.94 (a)
TMEM104 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem104 35
  • 87.77 (n)
  • 89.72 (a)
Tmem104 16
Tmem104 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM104 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM104 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem104 35
  • 87.9 (n)
  • 89.11 (a)
chicken
(Gallus gallus)
Aves TMEM104 35
  • 77.51 (n)
  • 82.02 (a)
TMEM104 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM104 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem104 35
  • 72.17 (n)
  • 74.95 (a)
zebrafish
(Danio rerio)
Actinopterygii tmem104 35
  • 71.69 (n)
  • 74.75 (a)
tmem104 36
  • 74 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002099 35
  • 56.37 (n)
  • 47.69 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5262 35
  • 51.36 (n)
  • 44.89 (a)
CG5262 36
  • 42 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C03A3.2 35
  • 49.07 (n)
  • 42.06 (a)
C03A3.2 36
  • 37 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.897 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
OneToOne
Species with no ortholog for TMEM104:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM104 Gene

ENSEMBL:
Gene Tree for TMEM104 (if available)
TreeFam:
Gene Tree for TMEM104 (if available)

Paralogs for TMEM104 Gene

Selected SIMAP similar genes for TMEM104 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TMEM104: view

No data available for Paralogs for TMEM104 Gene

Variants for TMEM104 Gene

Sequence variations from dbSNP and Humsavar for TMEM104 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs870178 -- 74,815,378(-) CGGGT(C/T)CCACC intron-variant
rs872640 -- 74,797,594(-) GACAA(C/T)GCCAA intron-variant
rs895690 -- 74,788,510(-) CAGAC(A/G)TGATA intron-variant
rs939537 -- 74,834,293(-) CAAAT(C/T)GTCCC intron-variant
rs939538 -- 74,834,259(-) CGGCG(A/G)CCTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM104 Gene

Variant ID Type Subtype PubMed ID
nsv908743 CNV Loss 21882294
nsv457907 CNV Loss 19166990
esv1000943 CNV Insertion 20482838
esv1113079 CNV Insertion 17803354
esv2716233 CNV Deletion 23290073
esv8400 CNV Gain 19470904
nsv518292 CNV Loss 19592680
esv2716234 CNV Deletion 23290073
nsv908744 CNV Loss 21882294
dgv3253n71 CNV Loss 21882294
nsv833540 CNV Loss 17160897

Relevant External Links for TMEM104 Gene

HapMap Linkage Disequilibrium report
TMEM104

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM104 Gene

Disorders for TMEM104 Gene

No disorders were found for TMEM104 Gene.

No data available for UniProtKB/Swiss-Prot for TMEM104 Gene

Publications for TMEM104 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  4. Defining the human deubiquitinating enzyme interaction landscape. (PMID: 19615732) Sowa M.E. … Harper J.W. (Cell 2009) 3
  5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3

Products for TMEM104 Gene

  • antibodies-online peptides for TMEM104
  • antibodies-online antibodies for TMEM104
  • antibodies-online kits for TMEM104

Sources for TMEM104 Gene

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