TMEM102 Gene
protein-coding GIFtS: 44
GCID: GC17P007338
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transmembrane protein 102
| |
Aliases
for TMEM102 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protein 1021 2 | | Common Beta-Chain Associated Protein2 3 | | CBAP2 3 | | FLJ368781 |
Export aliases for TMEM102 gene to outside databasesPrevious GC identifers: GC17P007280 GC17P007232 |
Summaries
for TMEM102 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TM102_HUMAN, Q8N9M5Function: Selectively involved in CSF2 deprivation-induced apoptosis via a mitochondria-dependent pathway
|
Genomic Views
for TMEM102 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010718.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMEM102 gene promoter:
Pax-5 CUTL1 Tal-1beta POU3F2 C/EBPalpha GATA-1 GATA-2 PPAR-gamma2 ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM102
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM102 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p13.1 Ensembl cytogenetic band: 17p13.1 HGNC cytogenetic band: 17p13.1TMEM102 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P007338: view genomic region
(about GC identifiers)
Start:
|
7,338,762 bp from pter |
End:
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7,340,998 bp from pter |
Size:
|
2,237 bases |
Orientation:
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plus strand |
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Proteins
for TMEM102 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TM102_HUMAN, Q8N9M5 (See
protein sequence)Recommended Name: Transmembrane protein 102 Size: 508 amino acids; 54175 Da
Subunit: Interacts with CSF2RB; this interaction occurs preferentially in the absence of CSF2
Subcellular location: Cell membrane; Single-pass membrane protein. Note=Although it is found at the cell surface, themajority of the molecules seems to be located in intracellular compartments
Secondary accessions: D3DTP8Explore the universe of human proteins at neXtProt for TMEM102: NX_Q8N9M5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N9M5
TMEM102 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_848613.1
ENSEMBL proteins: ENSP00000315387 ENSP00000379815
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
TMEM102 for ontologies About GeneDecksing
TMEM102 Antibody Products:
Assay Products for TMEM102: |
Protein
Domains /
Families
for TMEM102 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMEM102 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8N9M5ProtoNet protein and cluster: Q8N9M5 |
Function
for TMEM102 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TM102_HUMAN, Q8N9M5Function: Selectively involved in CSF2 deprivation-induced apoptosis via a mitochondria-dependent pathway
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM102 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM102
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TMEM102 (NM_178518) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM102 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM102 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM102 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
TMEM102 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for TMEM102:
|
Pathways & Interactions
for TMEM102 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM102
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for TMEM102 (Q8N9M52, 3 ENSP000003153874) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
TMEM102 for ontologies About GeneDecksing
|
Drugs & Compounds
for TMEM102 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM102
Search CenterWatch for drugs/clinical trials and news about TMEM102 / TM102
|
Transcripts
for TMEM102 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMEM102 gene: NM_178518.2 Unigene Cluster for TMEM102: Transmembrane protein 102 Hs.655662 [show with all ESTs]Unigene Representative Sequence: BC0461892 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000323206(uc002ggx.1 uc002ggy.2) ENST00000396568
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM102 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM102
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TMEM102 (NM_178518) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM102 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM102 |
Additional cDNA sequence: AK094197.1 BC046189.1 3 DOTS entries: DT.97836102 DT.95263482 DT.75144875 24/60 AceView cDNA sequences (see all 60): AW001057 NM_178518 BI907535 BM988219 AW299973 BI909129 AW297017 BI861896 BC046189 AK094197 CR626016 BM745742 BF343402 BX422077 BG753098 BX366946 BU191131 BQ643317 BX110318 BX364352 BX364353 CD366746 BQ893084 BM054767
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM102 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b |
|---|
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| SP1: | | | | | | | | | | | |
| SP2: | | | | | | | | | | |
ECgene alternative splicing isoforms for TMEM102
|
Expression
for TMEM102 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM102 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACGTCGTCGA
About this image
See TMEM102 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM102
SOURCE GeneReport for Unigene cluster: Hs.655662
SABiosciences Custom PCR Arrays for TMEM102
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM102
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM102 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM102 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM102 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM102 |
Orthologs
for TMEM102 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TMEM102 gene from 2/10 species (see all 10) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
TMEM1026 |
-- |
37(a) |
1 ↔ 1 |
AAWZ02037473(2244-4553) |
zebrafish
(Danio rerio) |
Actinopterygii |
FP015997.16 |
-- |
29(a) |
1 ↔ 1 |
7(23481362-23492221) |
ENSEMBL Gene Tree for TMEM102 (if available)
TreeFam Gene Tree for TMEM102 (if available) |
Paralogs
for TMEM102 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TMEM102 gene
- MB21D22
TMEM102 for paralogs About GeneDecksing
|
Genomic Variants
for TMEM102 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM102 (7338762 - 7340998 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TMEM102: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM102 |
|
Disorders
/ Diseases
for TMEM102 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 TMEM102 for disorders About MalaCards
TMEM102 for disorders About GeneDecksing
OMIM gene information: 613936
OMIM disorders: --
Export disorders for TMEM102 gene to outside databases
|
Publications
for TMEM102 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM102 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM102) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- CBAP interacts with the un-liganded common beta-subunit of the GM-CSF/IL-3/IL-5 receptor and induces apoptosis via mitochondrial dysfunction. (PubMed id 17828305)1, 2 Kao C.J....Yen J.J. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. (PubMed id 15324660)1 Jin J....Pawson T. (2004)
|
External Searches for TMEM102 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMEM102 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMEM102 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM102 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM102 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMEM102 gene:
Search GeneIP for patents involving TMEM102
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM102 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TMEM102 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM102 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM102 | | | OriGene Protein Over-expression Lysate for TMEM102 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMEM102 | | OriGene 3'-UTR Clone for TMEM102 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM102 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM102 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TMEM102 | | OriGene Custom Protein Services for TMEM102 | | | OriGene Custom Immunoassay Development | | |
| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM102 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM102 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM102 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM102 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM102 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM102 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for TMEM102 |
| |  |  |  |  | | | | |
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 | | | TMEM102 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM102 |
|  |  |  | | | | Search ThermoFisher Antibodies for TMEM102 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM102 |
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