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Aliases for TMEM102 Gene

Aliases for TMEM102 Gene

  • Transmembrane Protein 102 2 3
  • CBAP 3 4 6
  • Common Beta-Chain Associated Protein 3 4

External Ids for TMEM102 Gene

Summaries for TMEM102 Gene

GeneCards Summary for TMEM102 Gene

TMEM102 (Transmembrane Protein 102) is a Protein Coding gene. An important paralog of this gene is MB21D2.

UniProtKB/Swiss-Prot for TMEM102 Gene

  • Selectively involved in CSF2 deprivation-induced apoptosis via a mitochondria-dependent pathway.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM102 Gene

Genomics for TMEM102 Gene

Genomic Location for TMEM102 Gene

Start:
7,435,443 bp from pter
End:
7,437,679 bp from pter
Size:
2,237 bases
Orientation:
Plus strand

Genomic View for TMEM102 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM102 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM102 Gene

Regulatory Elements for TMEM102 Gene

Proteins for TMEM102 Gene

  • Protein details for TMEM102 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9M5-TM102_HUMAN
    Recommended name:
    Transmembrane protein 102
    Protein Accession:
    Q8N9M5
    Secondary Accessions:
    • D3DTP8

    Protein attributes for TMEM102 Gene

    Size:
    508 amino acids
    Molecular mass:
    54175 Da
    Quaternary structure:
    • Interacts with CSF2RB; this interaction occurs preferentially in the absence of CSF2.

neXtProt entry for TMEM102 Gene

Proteomics data for TMEM102 Gene at MOPED

Post-translational modifications for TMEM102 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM102 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM102 Gene

Domains for TMEM102 Gene

Protein Domains for TMEM102 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with TMEM102: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM102 Gene

Function for TMEM102 Gene

Molecular function for TMEM102 Gene

UniProtKB/Swiss-Prot Function: Selectively involved in CSF2 deprivation-induced apoptosis via a mitochondria-dependent pathway.

Gene Ontology (GO) - Molecular Function for TMEM102 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17828305
genes like me logo Genes that share ontologies with TMEM102: view

Phenotypes for TMEM102 Gene

GenomeRNAi human phenotypes for TMEM102:
genes like me logo Genes that share phenotypes with TMEM102: view

miRNA for TMEM102 Gene

miRTarBase miRNAs that target TMEM102

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM102 Gene

Localization for TMEM102 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM102 Gene

Cell membrane; Single-pass membrane protein. Note=Although it is found at the cell surface, the majority of the molecules seems to be located in intracellular compartments.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM102 Gene COMPARTMENTS Subcellular localization image for TMEM102 gene
Compartment Confidence
plasma membrane 5
cytosol 1
extracellular 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMEM102 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA 17828305
GO:0005886 plasma membrane IEA --
GO:0009986 cell surface IDA 17828305
GO:0016021 integral component of membrane IEA --
GO:0043234 protein complex IDA 23620790
genes like me logo Genes that share ontologies with TMEM102: view

Pathways for TMEM102 Gene

SuperPathways for TMEM102 Gene

No Data Available

Interacting Proteins for TMEM102 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000315387%0d%0a9606.ENSP00000447300%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000306330%0d%0a
Selected Interacting proteins: Q8N9M5-TM102_HUMAN ENSP00000315387 for TMEM102 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for TMEM102 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007165 signal transduction IDA 17828305
GO:0010820 positive regulation of T cell chemotaxis IEA --
GO:0034097 response to cytokine IDA 17828305
GO:0045785 positive regulation of cell adhesion IDA 23620790
genes like me logo Genes that share ontologies with TMEM102: view

No data available for Pathways by source for TMEM102 Gene

Transcripts for TMEM102 Gene

Unigene Clusters for TMEM102 Gene

Transmembrane protein 102:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM102 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2:

Relevant External Links for TMEM102 Gene

GeneLoc Exon Structure for
TMEM102
ECgene alternative splicing isoforms for
TMEM102

Expression for TMEM102 Gene

mRNA expression in normal human tissues for TMEM102 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM102 Gene

SOURCE GeneReport for Unigene cluster for TMEM102 Gene Hs.655662

genes like me logo Genes that share expressions with TMEM102: view

Orthologs for TMEM102 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM102 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM102 36
  • 99.54 (n)
  • 99.61 (a)
TMEM102 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM102 36
  • 85.55 (n)
  • 84.07 (a)
TMEM102 37
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM102 36
  • 85.07 (n)
  • 85.89 (a)
TMEM102 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem102 36
  • 80.4 (n)
  • 79.8 (a)
Tmem102 16
Tmem102 37
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM102 37
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem102 36
  • 80.58 (n)
  • 78.18 (a)
lizard
(Anolis carolinensis)
Reptilia TMEM102 37
  • 38 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii TMEM102 37
  • 29 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 18 (a)
ManyToMany
CSA.9655 37
  • 27 (a)
ManyToMany
Species with no ortholog for TMEM102:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM102 Gene

ENSEMBL:
Gene Tree for TMEM102 (if available)
TreeFam:
Gene Tree for TMEM102 (if available)

Paralogs for TMEM102 Gene

Paralogs for TMEM102 Gene

genes like me logo Genes that share paralogs with TMEM102: view

Variants for TMEM102 Gene

Sequence variations from dbSNP and Humsavar for TMEM102 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1056450 -- 7,437,332(+) TTGCC(C/T)CACTA synonymous-codon, reference
rs3809718 - 7,436,308(-) CCCGG(A/G)CGTAG reference, missense
rs9895569 -- 7,436,104(+) CTTGC(C/G)TTTGG intron-variant
rs12950374 -- 7,435,519(+) AAGCC(A/G)CAGAC utr-variant-5-prime
rs34011222 -- 7,435,421(+) GGCTG(-/A)AAAAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM102 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV Deletion 17116639
nsv457659 CNV Loss 19166990
nsv907644 CNV Loss 21882294
nsv523672 CNV Loss 19592680
dgv3054n71 CNV Loss 21882294

Relevant External Links for TMEM102 Gene

HapMap Linkage Disequilibrium report
TMEM102

Disorders for TMEM102 Gene

No disorders were found for TMEM102 Gene.

No data available for UniProtKB/Swiss-Prot for TMEM102 Gene

Publications for TMEM102 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. CBAP interacts with the un-liganded common beta-subunit of the GM- CSF/IL-3/IL-5 receptor and induces apoptosis via mitochondrial dysfunction. (PMID: 17828305) Kao C.J. … Yen J.J. (Oncogene 2008) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. (PMID: 15324660) Jin J. … Pawson T. (Curr. Biol. 2004) 3

Products for TMEM102 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate TMEM102
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM102
    • Block miRNA regulation of TMEM102 using miScript Target Protectors
    • antibodies-online peptides for TMEM102
    • antibodies-online antibodies for TMEM102
    • antibodies-online kits for TMEM102

    Sources for TMEM102 Gene

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