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Aliases for TMEM101 Gene

Aliases for TMEM101 Gene

  • Transmembrane Protein 101 2 3 5
  • Putative NF-Kappa-B-Activating Protein 130 4

External Ids for TMEM101 Gene

Previous GeneCards Identifiers for TMEM101 Gene

  • GC17M039445
  • GC17M039446
  • GC17M042088
  • GC17M037852

Summaries for TMEM101 Gene

GeneCards Summary for TMEM101 Gene

TMEM101 (Transmembrane Protein 101) is a Protein Coding gene. GO annotations related to this gene include signal transducer activity.

UniProtKB/Swiss-Prot for TMEM101 Gene

  • May activate NF-kappa-B signaling pathways.

Additional gene information for TMEM101 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM101 Gene

Genomics for TMEM101 Gene

Regulatory Elements for TMEM101 Gene

Enhancers for TMEM101 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H044094 1.9 FANTOM5 Ensembl ENCODE dbSUPER 21.6 -72.6 -72644 4 HDGF FOXA2 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 ASB16 G6PC3 TMEM101 ASB16-AS1 LSM12 RNU6-131P C17orf53 HDAC5 ENSG00000221044 PYY
GH17H043983 1.6 FANTOM5 Ensembl ENCODE 17.1 +40.2 40175 1 PKNOX1 FOXA2 MLX ARID4B FEZF1 DMAP1 ZNF2 SLC30A9 SP3 SP5 TMEM101 MPP2 PPY ENSG00000221044 NAGS G6PC3 GC17P043983
GH17H044013 1.2 ENCODE 15.2 +9.6 9560 1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A ENSG00000267604 TMEM101 MEOX1 RN7SL507P LINC01180 SMCO4P1 RN7SL405P ENSG00000267788 MPP2 MEIOC
GH17H043994 1.2 Ensembl ENCODE 10.2 +29.4 29417 0 HDAC1 RB1 ZNF76 KLF17 DEAF1 ZNF2 ZSCAN9 RAD21 GLIS2 ZNF143 TMEM101 NAGS GC17P043983
GH17H043900 0.9 ENCODE 10.7 +123.6 123573 1 PKNOX1 ATF1 KLF17 SIN3A THRB RFX5 GLIS2 FOS EGR2 SP3 PPY TMEM101 ENSG00000221044 MPP2 GC17P043880
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM101 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM101 Gene

Chromosome:
17
Start:
44,011,188 bp from pter
End:
44,024,260 bp from pter
Size:
13,073 bases
Orientation:
Minus strand

Genomic View for TMEM101 Gene

Genes around TMEM101 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM101 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM101 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM101 Gene

Proteins for TMEM101 Gene

  • Protein details for TMEM101 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96IK0-TM101_HUMAN
    Recommended name:
    Transmembrane protein 101
    Protein Accession:
    Q96IK0
    Secondary Accessions:
    • B2R9N6

    Protein attributes for TMEM101 Gene

    Size:
    257 amino acids
    Molecular mass:
    28795 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM101 Gene

Post-translational modifications for TMEM101 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TMEM101 Gene

Domains & Families for TMEM101 Gene

Gene Families for TMEM101 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMEM101 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM101 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM101: view

No data available for UniProtKB/Swiss-Prot for TMEM101 Gene

Function for TMEM101 Gene

Molecular function for TMEM101 Gene

UniProtKB/Swiss-Prot Function:
May activate NF-kappa-B signaling pathways.

Phenotypes From GWAS Catalog for TMEM101 Gene

Gene Ontology (GO) - Molecular Function for TMEM101 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IMP 12761501
genes like me logo Genes that share ontologies with TMEM101: view
genes like me logo Genes that share phenotypes with TMEM101: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM101

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM101
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM101 Gene

Localization for TMEM101 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM101 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM101 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM101 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM101: view

Pathways & Interactions for TMEM101 Gene

SuperPathways for TMEM101 Gene

No Data Available

Interacting Proteins for TMEM101 Gene

Selected Interacting proteins: Q96IK0-TM101_HUMAN for TMEM101 Gene via IID

Gene Ontology (GO) - Biological Process for TMEM101 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP 12761501
genes like me logo Genes that share ontologies with TMEM101: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM101 Gene

Drugs & Compounds for TMEM101 Gene

No Compound Related Data Available

Transcripts for TMEM101 Gene

Unigene Clusters for TMEM101 Gene

Transmembrane protein 101:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM101
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM101 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4
SP1: -
SP2: -
SP3:

Relevant External Links for TMEM101 Gene

GeneLoc Exon Structure for
TMEM101
ECgene alternative splicing isoforms for
TMEM101

Expression for TMEM101 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM101 Gene

Protein differential expression in normal tissues from HIPED for TMEM101 Gene

This gene is overexpressed in Urine (33.6), Liver (10.2), and Islet of Langerhans (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMEM101 Gene



Protein tissue co-expression partners for TMEM101 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM101 Gene:

TMEM101

SOURCE GeneReport for Unigene cluster for TMEM101 Gene:

Hs.514211

Evidence on tissue expression from TISSUES for TMEM101 Gene

  • Lung(4.2)
  • Muscle(4.2)
  • Nervous system(2.8)
genes like me logo Genes that share expression patterns with TMEM101: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM101 Gene

Orthologs for TMEM101 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM101 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM101 33 34
  • 99.87 (n)
dog
(Canis familiaris)
Mammalia TMEM101 33 34
  • 94.42 (n)
cow
(Bos Taurus)
Mammalia TMEM101 33 34
  • 93.26 (n)
rat
(Rattus norvegicus)
Mammalia Tmem101 33
  • 88.85 (n)
mouse
(Mus musculus)
Mammalia Tmem101 33 16 34
  • 87.55 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM101 34
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM101 34
  • 80 (a)
OneToOne
LOC100859387 33
  • 78.34 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM101 34
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem101 33
  • 71.01 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC572154 33
  • 71.47 (n)
tmem101 34
  • 70 (a)
OneToOne
Species where no ortholog for TMEM101 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM101 Gene

ENSEMBL:
Gene Tree for TMEM101 (if available)
TreeFam:
Gene Tree for TMEM101 (if available)

Paralogs for TMEM101 Gene

No data available for Paralogs for TMEM101 Gene

Variants for TMEM101 Gene

Sequence variations from dbSNP and Humsavar for TMEM101 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000233251 -- 44,013,650(+) AGAGA(-/CT)CTGTT intron-variant
rs1000281228 -- 44,025,523(+) GCCCA(A/G)CTCTC upstream-variant-2KB
rs1000506535 -- 44,016,707(+) TTTCC(A/C)CTGAA intron-variant, upstream-variant-2KB
rs1000612799 -- 44,022,939(+) ATAAG(C/T)GAATG intron-variant
rs1000959208 -- 44,018,620(+) TTGAC(A/G)AGGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM101 Gene

Variant ID Type Subtype PubMed ID
nsv1146669 OTHER inversion 26484159
nsv833454 CNV loss 17160897

Variation tolerance for TMEM101 Gene

Residual Variation Intolerance Score: 25.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM101 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM101

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM101 Gene

Disorders for TMEM101 Gene

Relevant External Links for TMEM101

Genetic Association Database (GAD)
TMEM101
Human Genome Epidemiology (HuGE) Navigator
TMEM101
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM101

No disorders were found for TMEM101 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM101 Gene

Publications for TMEM101 Gene

  1. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PMID: 12761501) Matsuda A … Sugano S (Oncogene 2003) 2 3 4 60
  2. Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes. (PMID: 20532202) Naukkarinen J … ENGAGE Consortium (PLoS genetics 2010) 3 45 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P … Aldabe R (Proceedings of the National Academy of Sciences of the United States of America 2012) 4 60
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J … Yang X (Molecular systems biology 2011) 3 60

Products for TMEM101 Gene

Sources for TMEM101 Gene

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