TMEM101 Gene
protein-coding GIFtS: 41
GCID: GC17M042088
|
|
transmembrane protein 101
| |
Aliases
for TMEM101 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protein 1011 2 | | Putative NF-Kappa-B-Activating Protein 1302 3 | | FLJ239871 | | MGC42511 |
Export aliases for TMEM101 gene to outside databasesPrevious GC identifers: GC17M039445 GC17M039446 GC17M037852 |
Summaries
for TMEM101 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TM101_HUMAN, Q96IK0Function: May activate NF-kappa-B signaling pathways
|
Genomic Views
for TMEM101 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMEM101 gene promoter:
E2F-4 E2F-3a E2F-5 AP-1 Sp1 Nkx2-5 E2F-2 YY1 E2F E2F-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM101
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM101 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21.31 Ensembl cytogenetic band: 17q21.31 HGNC cytogenetic band: 17q21.31TMEM101 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M042088: view genomic region
(about GC identifiers)
Start:
|
42,088,556 bp from pter |
End:
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42,101,314 bp from pter |
Size:
|
12,759 bases |
Orientation:
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minus strand |
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Proteins
for TMEM101 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TM101_HUMAN, Q96IK0 (See
protein sequence)Recommended Name: Transmembrane protein 101 Size: 257 amino acids; 28795 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: B2R9N6Explore the universe of human proteins at neXtProt for TMEM101: NX_Q96IK0
TMEM101 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_115752.1
ENSEMBL proteins: ENSP00000468025 ENSP00000466307 ENSP00000466385 ENSP00000468388 ENSP00000467545 ENSP00000465903 ENSP00000206380 ENSP00000442994
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- | | GO:0016021 | integral to membrane |
IEA | -- |
TMEM101 for ontologies About GeneDecksing
TMEM101 Antibody Products:
Assay Products for TMEM101: |
Protein
Domains /
Families
for TMEM101 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q96IK0 |
Function
for TMEM101 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TM101_HUMAN, Q96IK0Function: May activate NF-kappa-B signaling pathways
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM101 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM101
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TMEM101 (NM_032376) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM101 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM101 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM101 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
TMEM101 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for TMEM101:
|
Pathways & Interactions
for TMEM101 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM101
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for TMEM101 (ENSP000002063804) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
TMEM101 for ontologies About GeneDecksing
|
Drugs & Compounds
for TMEM101 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM101
Search CenterWatch for drugs/clinical trials and news about TMEM101 / TM101
|
Transcripts
for TMEM101 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMEM101 gene: NM_032376.2 Unigene Cluster for TMEM101: Transmembrane protein 101 Hs.514211 [show with all ESTs]Unigene Representative Sequence: BM5423089 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000589334 ENST00000587529 ENST00000585950 ENST00000592127 ENST00000590905
ENST00000586174 ENST00000591162 ENST00000206380(uc002ieu.3 uc010wis.2)
ENST00000542039
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM101 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM101
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TMEM101 (NM_032376) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM101 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM101 |
Additional cDNA sequence: AB097008.1 AK130810.1 AK172826.1 AK294237.1 AK313855.1 BC007438.2 7 DOTS entries: DT.86660748 DT.100814863 DT.100814867 DT.100814876 DT.40115457 DT.97808601 DT.75157662 24/297 AceView cDNA sequences (see all 297): BM919893 AW959275 AI420766 BU729337 CB160509 BM048827 CR606986 CF529517 CR605090 CR610516 CR590675 BQ932676 NM_032376 CF127002 CR625688 BU623564 CR611268 CR596239 CR614002 CA395692 AL543851 BE646197 BI838114 CR614500
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM101 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | | | |
| SP2: | | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TMEM101
|
Expression
for TMEM101 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM101 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTGGCCTGG
About this image
See TMEM101 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM101
SOURCE GeneReport for Unigene cluster: Hs.514211
SABiosciences Custom PCR Arrays for TMEM101
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM101
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM101 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM101 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM101 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM101 |
Orthologs
for TMEM101 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TMEM101 gene from 5/14 species (see all 14) About this table
ENSEMBL Gene Tree for TMEM101 (if available)
TreeFam Gene Tree for TMEM101 (if available) |
Paralogs
for TMEM101 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TMEM101 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM101 (42088556 - 42101314 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TMEM101: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM101 |
|
Disorders
/ Diseases
for TMEM101 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TMEM101 for disorders About GeneDecksing
1  disease for TMEM101: About MalaCardsobesity
Human Genome Epidemiology (HuGE) Navigator: TMEM101 (1 document)
Export disorders for TMEM101 gene to outside databases
|
Publications
for TMEM101 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM101 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM101) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PubMed id 12761501)1, 2, 3 Matsuda A....Sugano S. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Use of genome-wide expression data to mine the ' Gray Zone' of GWA studies leads to novel candidate obesity genes. (PubMed id 20532202)1 Naukkarinen J....Peltonen L. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for TMEM101 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMEM101 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMEM101 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM101 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM101 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMEM101 gene:
Search GeneIP for patents involving TMEM101
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM101 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TMEM101 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM101 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM101 | | | OriGene Protein Over-expression Lysate for TMEM101 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMEM101 | | OriGene 3'-UTR Clone for TMEM101 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM101 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM101 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TMEM101 | | OriGene Custom Protein Services for TMEM101 | | | OriGene Custom Immunoassay Development | | |
| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM101 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM101 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM101 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM101 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM101 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM101 |
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 |  |  |  | |
| | | | Search Tocris compounds for TMEM101 |
| |  |  |  |  | | | | |
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 | | | TMEM101 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM101 |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM101 |
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