Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TMEM100 Gene

protein-coding   GIFtS: 46
GCID: GC17M053796

Transmembrane Protein 100

  See TMEM100-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Transmembrane Protein 1001 2

External Ids:    HGNC: 256071   Entrez Gene: 552732   Ensembl: ENSG000001662927   UniProtKB: Q9NV293   

Export aliases for TMEM100 gene to outside databases

Previous GC identifers: GC17M051152 GC17M049156


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for TMEM100 Gene:
TMEM100 (transmembrane protein 100) is a protein-coding gene. Diseases associated with TMEM100 include autism spectrum disorder.

UniProtKB/Swiss-Prot: TM100_HUMAN, Q9NV29
Function: Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through
the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as
GDF2/BMP9 and BMP10 (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMEM100 gene promoter:
         PPAR-alpha   AML1a   Nkx6-1   c-Myb   Gfi-1   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM100 promoter sequence
   Search Chromatin IP Primers for TMEM100

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM100


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q22   Ensembl cytogenetic band:  17q22   HGNC cytogenetic band: 17q23.1

TMEM100 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM100 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M053796:  view genomic region     (about GC identifiers)

Start:
53,796,988 bp from pter      End:
53,809,482 bp from pter
Size:
12,495 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TM100_HUMAN, Q9NV29 (See protein sequence)
Recommended Name: Transmembrane protein 100  
Size: 134 amino acids; 14386 Da
Sequence caution: Sequence=AC009837; Type=Erroneous gene model prediction;
Secondary accessions: D3DTY7 I3L214 Q96FZ0

Explore the universe of human proteins at neXtProt for TMEM100: NX_Q9NV29

Explore proteomics data for TMEM100 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TMEM100 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001093110.1  NP_060756.2  

    ENSEMBL proteins: 
     ENSP00000395328   ENSP00000465638   ENSP00000459290  

    TMEM100 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TMEM100
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TMEM100
    GenScript Custom Purified and Recombinant Proteins Services for TMEM100
    Novus Biologicals TMEM100 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TMEM100

     
    Search eBioscience for Proteins for TMEM100 

     
    Search antibodies-online for proteins for TMEM100 

     
    antibodies-online peptides for TMEM100

    TMEM100 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for TMEM100
    OriGene Custom Antibody Services for TMEM100
    Novus Biologicals TMEM100 Antibodies
    Abcam antibodies for TMEM100
    Cloud-Clone Corp. Antibodies for TMEM100
    Search ThermoFisher Antibodies for TMEM100
    antibodies-online antibodies for TMEM100 (15 products) 

    TMEM100 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TMEM100
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TMEM100
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TMEM100
    Cloud-Clone Corp. CLIAs for TMEM100
    Search eBioscience for ELISAs for TMEM100 
    antibodies-online kits for TMEM100 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR028068 PIRT

    Graphical View of Domain Structure for InterPro Entry Q9NV29

    ProtoNet protein and cluster: Q9NV29


    Find genes that share domains with TMEM100           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TM100_HUMAN, Q9NV29
    Function: Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through
    the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as
    GDF2/BMP9 and BMP10 (By similarity)
    Induction: Up-regulated by GDF2/BMP9 and BMP10 (at protein level)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    Find genes that share ontologies with TMEM100           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TMEM100:
     Actin fiber cells 

         7 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Tmem100):
     cardiovascular system  embryogenesis  growth/size/body  homeostasis/metabolism  mortality/aging 
     muscle  normal 

    Find genes that share phenotypes with TMEM100           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TMEM100

    miRNA
    Products:
        
    miRTarBase miRNAs that target TMEM100:
    hsa-mir-16-5p (MIRT031519), hsa-mir-93-5p (MIRT027944), hsa-mir-103a-3p (MIRT027000)

    Block miRNA regulation of human, mouse, rat TMEM100 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TMEM100 (see all 39):
    hsa-miR-302d hsa-miR-520e hsa-miR-15a hsa-miR-106a hsa-miR-548k hsa-miR-938 hsa-miR-624* hsa-miR-3653
    SwitchGear 3'UTR luciferase reporter plasmidTMEM100 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TMEM100
    Predesigned siRNA for gene silencing in human, mouse, rat TMEM100

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TMEM100

    Clone
    Products:
         
    OriGene clones in human, mouse for TMEM100 (see all 11)
    OriGene ORF clones in mouse, rat for TMEM100
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TMEM100 (NM_001099640)
    Sino Biological Human cDNA Clone for TMEM100
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM100
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM100

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TMEM100
    Browse ESI BIO Cell Lines and PureStem Progenitors for TMEM100 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM100


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TM100_HUMAN, Q9NV29: Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein
    (Potential). Perikaryon. Cytoplasm, perinuclear region. Endoplasmic reticulum. Note=Colocalized with HSPA5 in the
    endoplasmic reticulum (ER). Enriched in ER microsome. Colocalized with BMP4 in neural cell bodies and neural
    fibers of the enteric nervous system
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ----
    GO:0005783endoplasmic reticulum IDA--
    GO:0005886plasma membrane IDA--
    GO:0016021integral component of membrane IEA--
    GO:0043204perikaryon IDA--

    Find genes that share ontologies with TMEM100           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM100
    Interactions:

        Search GeneGlobe Interaction Network for TMEM100

    1 Interacting protein for TMEM100 (Q9NV293) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CREB3O438893I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0001570vasculogenesis IEA--
    GO:0001701in utero embryonic development IEA--
    GO:0007219Notch signaling pathway IEA--
    GO:0008150biological_process ----

    Find genes that share ontologies with TMEM100           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMEM100 (TM100)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TMEM100 gene (2 alternative transcripts): 
    NM_001099640.1  NM_018286.2  

    Unigene Cluster for TMEM100:

    Transmembrane protein 100
    Hs.173233  [show with all ESTs]
    Unigene Representative Sequence: NM_001099640
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000424486(uc002iuj.4) ENST00000575734 ENST00000571679 ENST00000575685
    ENST00000570586 ENST00000575806
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TMEM100 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TMEM100 (see all 39):
    hsa-miR-302d hsa-miR-520e hsa-miR-15a hsa-miR-106a hsa-miR-548k hsa-miR-938 hsa-miR-624* hsa-miR-3653
    SwitchGear 3'UTR luciferase reporter plasmidTMEM100 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TMEM100
    Predesigned siRNA for gene silencing in human, mouse, rat TMEM100
    Clone
    Products:
         
    OriGene clones in human, mouse for TMEM100 (see all 11)
    OriGene ORF clones in mouse, rat for TMEM100
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TMEM100 (NM_001099640)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM100
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM100
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TMEM100
    OriGene qSTAR qPCR primer pairs in human, mouse for TMEM100
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMEM100
      QuantiTect SYBR Green Assays in human, mouse, rat TMEM100
      QuantiFast Probe-based Assays in human, mouse, rat TMEM100

    Additional mRNA sequence: 

    AK001832.1 AK095175.1 BC010128.2 

    4 DOTS entries:

    DT.211824  DT.100745691  DT.100745693  DT.40114207 

    Selected AceView cDNA sequences (see all 95):

    BM974477 AA922684 CR601559 BU679717 BC010128 BX373833 AA683497 BQ674815 
    BU682087 BM974455 AA775527 BQ027747 CF994364 AL546340 BQ889285 AA001732 
    BE315005 CR607494 AA977654 AL044840 CF594266 NM_018286 BU688213 BM985358 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM100    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c
    SP1:                    -     -           -     -                     
    SP2:                          -           -                           
    SP3:                    -     -                                       
    SP4:                                      -     -                     
    SP5:                                      -     -                     


    ECgene alternative splicing isoforms for TMEM100

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TMEM100 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGTGCACA
    TMEM100 Expression
    About this image


    TMEM100 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Kidney (Urinary System)    fully expand to see all 9 entries
             Proximal Renal Vesicle Cells Renal Vesicle
             Metanephros
     
     Bone (Muscoskeletal System)    fully expand to see all 5 entries
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 4 entries
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
     
     Adipose (Muscoskeletal System)    fully expand to see all 3 entries
             HyStem+BMP4-induced E15 cells
     
     Intermediate Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             Mesonephric cells Mesonephros
             Mesonephros
    TMEM100 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMEM100 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.173233

    UniProtKB/Swiss-Prot: TM100_HUMAN, Q9NV29
    Tissue specificity: Expressed in neurons of the myenteric and submucosal plexuses in the gastric body, jejunum and
    proximal colon. Expressed in arterial endothelial cells and neurons of the central nervous system and peripheral
    nervous system. Expressed in umbilical artery endothelial cells (at protein level)

        Custom PCR Arrays for TMEM100
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TMEM100
    OriGene qSTAR qPCR primer pairs in human, mouse for TMEM100
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMEM100
    QuantiTect SYBR Green Assays in human, mouse, rat TMEM100
    QuantiFast Probe-based Assays in human, mouse, rat TMEM100
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM100

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for TMEM100 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem1001 , 5 transmembrane protein 1001, 5 85.07(n)1
    85.07(a)1
      11 (54.75 cM)5
    678881  NM_026433.21  NP_080709.11 
     900303485 
    chicken
    (Gallus gallus)
    Aves TMEM1001 transmembrane protein 100 72.64(n)
    76.12(a)
      417398  XM_415651.3  XP_415651.1 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM1006
    transmembrane protein 100
    73(a)
    1 ↔ 1
    GL343646.1(135107-135511)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tmem1001 transmembrane protein 100 69.25(n)
    73.64(a)
      100490268  XM_004918562.1  XP_004918619.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003347421 transmembrane protein 100-like 65.42(n)
    63.43(a)
      100334742  XM_002666996.3  XP_002667042.1 


    ENSEMBL Gene Tree for TMEM100 (if available)
    TreeFam Gene Tree for TMEM100 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TMEM100 (see all 311)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1921189451,2
    --53796490(+) TGAAGA/GCACAG 2 -- int10--------
    rs1433058211,2
    C--53796732(+) TTCCAA/GGTTTT 2 -- int10--------
    rs802438651,2
    C,F--53796776(+) TTAAGG/ATGGTT 2 -- int11Minor allele frequency- A:0.04WA 118
    rs1850047101,2
    C--53796790(+) ACTACA/GTGAAT 2 -- int10--------
    rs790582181,2
    C,F--53796839(+) AGCTGT/CGGACT 2 -- int11Minor allele frequency- C:0.05WA 118
    rs1512707091,2
    --53796950(+) AGTTGC/GTGCTG 2 -- int10--------
    rs1405744721,2
    --53797119(+) AGTAAC/TGAAAA 2 -- ut310--------
    rs1906451491,2
    C--53797267(+) ACCATC/TTAAGA 2 -- ut310--------
    rs1930477601,2
    --53797544(+) CAGACA/GCCAGT 2 -- ut310--------
    rs126020811,2
    C,F,H--53797587(+) TTTCAT/CAGACA 2 -- ut318Minor allele frequency- C:0.01NS EA NA 678

    HapMap Linkage Disequilibrium report for TMEM100 (53796988 - 53809482 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TMEM100:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2100CNV Loss18451855
    nsv518015CNV Loss19592680
    nsv908620CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TMEM100
    DNA2.0 Custom Variant and Variant Library Synthesis for TMEM100

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    1 disease for TMEM100:    
    About MalaCards
    autism spectrum disorder


    Find genes that share disorders with TMEM100           About GenesLikeMe

    Genetic Association Database (GAD): TMEM100
    Human Genome Epidemiology (HuGE) Navigator: TMEM100 (2 documents)

    Export disorders for TMEM100 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TMEM100 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with TMEM100)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Distribution of TMEM100 in the mouse and human gastrointestinal tract--a novel marker of enteric nerves. (PubMed id 23485812)1, 2 Eisenman S.T....Farrugia G. (Neuroscience 2013)
    2. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1, 4 de Krom M....van Ree J.M. (Biol. Psychiatry 2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Association of lung adenocarcinoma clinical stage with gene expression pattern in noninvolved lung tissue. (PubMed id 22223368)1 Frullanti E....Dragani T.A. (Int. J. Cancer 2012)
    6. Genome-wide association study of body height in African Americans: the Women's Health Initiative SNP Health Association Resource (SHARe). (PubMed id 22021425)1 Carty C.L....Kooperberg C. (Hum. Mol. Genet. 2012)
    7. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    8. Tmem100, an ALK1 receptor signaling-dependent gene essential for arterial endothelium differentiation and vascular morphogenesis. (PubMed id 22783020)2 Somekawa S.... Saito Y. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    9. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (Biochem. Biophys. Res. Commun. 2006)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 55273 HGNC: 25607 AceView: FLJ10970 Ensembl:ENSG00000166292 euGenes: HUgn55273
    ECgene: TMEM100 H-InvDB: TMEM100

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TMEM100 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TMEM100 gene:
    Search GeneIP for patents involving TMEM100

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TMEM100   OriGene RNAi products in human, mouse, rat for TMEM100  
     OriGene qPCR primer pairs and template standards for TMEM100   OriGene Protein Over-expression Lysate for TMEM100  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TMEM100  
     OriGene qSTAR qPCR primer pairs in human, mouse for TMEM100   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TMEM100   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TMEM100   OriGene Custom Protein Services for TMEM100  

     
     
     Block miRNA regulation of human, mouse, rat TMEM100 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TMEM100
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM100 Predesigned siRNA for gene silencing in human, mouse, rat TMEM100
     QuantiFast Probe-based Assays in human, mouse, rat TMEM100 QuantiTect SYBR Green Assays in human, mouse, rat TMEM100
     Custom PCR Arrays for TMEM100 Search Chromatin IP Primers for TMEM100
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMEM100  Search GeneGlobe Interaction Network for TMEM100
     Regulatory tfbs in TMEM100 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TMEM100 GenScript cDNA clones with any tag delivered in your preferred vector for TMEM100
     GenScript Custom Assay Services for TMEM100 GenScript Custom overexpressing Cell Line Services for TMEM100
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TMEM100 (TM100)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for TMEM100
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TMEM100 antibodies
     TMEM100 lysates
     Antibodies for TMEM100
     See all of Abcam's Antibodies, Kits and Proteins for TMEM100
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for TMEM100
     Antibodies for TMEM100
     ELISAs for TMEM100
     CLIAs for TMEM100



     Browse ESI BIO Cell Lines and PureStem Progenitors for TMEM100
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM100
     SwitchGear 3'UTR luciferase reporter plasmids for TMEM100
     SwitchGear Promoter luciferase reporter plasmids for TMEM100
     Search ThermoFisher Antibodies for TMEM100
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM100
     Browse compounds at ApexBio
     Search Addgene for plasmids for TMEM100
      Search eBioscience for proteins for TMEM100
      Search eBioscience for elisas for TMEM100
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for TMEM100
     antibodies-online antibodies for TMEM100 (15 products)
     antibodies-online kits for TMEM100 (8 products)
     antibodies-online peptides for TMEM100
      Search antibodies-online for proteins for TMEM100
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TMEM100 gene at Home site.
    Version: 3.12.250 16 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4