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TMEFF2 Gene

protein-coding   GIFtS: 54
GCID: GC02M192777

Transmembrane Protein With EGF-Like And Two Follistatin-Like...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Protein With EGF-Like And Two Follistatin-Like Domains
21 2
     TR2 5
HPP12 3 5     Cancer/Testis Antigen Family 1201
tomoregulin1 2     Member 21
Transmembrane Protein TENB21 2     CT120.22
Hyperplastic Polyposis Protein 12 3     Cancer/Testis Antigen Family 120, Member 22
TENB22 3     tomoregulin-22
TPEF2 3     Transmembrane Protein With EGF-Like And Two Follistatin-Like Domains3
TR-22 3     

External Ids:    HGNC: 118671   Entrez Gene: 236712   Ensembl: ENSG000001443397   OMIM: 6057345   UniProtKB: Q9UIK53   

Export aliases for TMEFF2 gene to outside databases

Previous GC identifers: GC02M190998 GC02M191517 GC02M193017 GC02M192640 GC02M192522 GC02M184672


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMEFF2 Gene:
TMEFF2 (transmembrane protein with EGF-like and two follistatin-like domains 2) is a protein-coding gene. An important paralog of this gene is MSANTD3-TMEFF1.

UniProtKB/Swiss-Prot: TEFF2_HUMAN, Q9UIK5
Function: May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer
cell proliferation, probably by promoting ERK1/2 phosphorylation

Gene Wiki entry for TMEFF2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMEFF2 gene promoter:
         E2F-4   E2F-3a   E2F-5   Sp1   E2F-2   MEF-2A   E2F   E2F-1   Ik-2   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEFF2 promoter sequence
   Search Chromatin IP Primers for TMEFF2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEFF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q32.3   Ensembl cytogenetic band:  2q32.3   HGNC cytogenetic band: 2q32.3

TMEFF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEFF2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M192777:  view genomic region     (about GC identifiers)

Start:
192,813,769 bp from pter      End:
193,060,435 bp from pter
Size:
246,667 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TEFF2_HUMAN, Q9UIK5 (See protein sequence)
Recommended Name: Tomoregulin-2 precursor  
Size: 374 amino acids; 41428 Da
Sequence caution: Sequence=BAA90820.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Mitochondrial
contamination starting in position 361;
1 PDB 3D structure from and Proteopedia for TMEFF2:
2FMW (3D)    
Secondary accessions: Q2FA44 Q4ZFW4 Q53H90 Q53RE1 Q8N2R5 Q9NR15 Q9NSS5 Q9P2Y9 Q9UK65
Alternative splicing: 3 isoforms:  Q9UIK5-1   Q9UIK5-2   Q9UIK5-3   

Explore the universe of human proteins at neXtProt for TMEFF2: NX_Q9UIK5

Explore proteomics data for TMEFF2 at MOPED

Post-translational modifications: 

  • N-glycosylated. Contains chondroitin sulfate glycosaminoglycans1
  • A soluble form (TMEFF2-ECD) is produced by proteolytic shedding. This shedding can be induced by phorbol ester or
    proinflammatory cytokines such as TNFalpha, and is mediated by ADAM171
  • Glycosylation2 at Asn55, Asn204, Asn230
  • Modification sites at PhosphoSitePlus

  • See TMEFF2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057276.2  
    ENSEMBL proteins: 
     ENSP00000376128   ENSP00000272771   ENSP00000386871  

    TMEFF2 Human Recombinant Protein Products:

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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR002350 Kazal_dom
     IPR000742 EG-like_dom
     IPR013032 EGF-like_CS

    Graphical View of Domain Structure for InterPro Entry Q9UIK5

    ProtoNet protein and cluster: Q9UIK5

    1 Blocks protein domain: IPB006210 Type I EGF

    UniProtKB/Swiss-Prot: TEFF2_HUMAN, Q9UIK5
    Similarity: Belongs to the tomoregulin family
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 2 Kazal-like domains


    Find genes that share domains with TMEFF2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TEFF2_HUMAN, Q9UIK5
    Function: May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer
    cell proliferation, probably by promoting ERK1/2 phosphorylation
    Induction: Down-regulated in tumor cell lines in response to a high level of methylation in the 5' region. The CpG
    island methylation correlates with TMEFF2 silencing in tumor cell lines

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with TMEFF2           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tmeff2):
     adipose tissue  growth/size/body  mortality/aging  nervous system  reproductive system 
     tumorigenesis 

    Find genes that share phenotypes with TMEFF2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Tmeff2tm1Lex for TMEFF2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMEFF2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMEFF2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMEFF2

    miRNA
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    miRTarBase miRNAs that target TMEFF2:
    hsa-mir-124-3p (MIRT022402), hsa-mir-335-5p (MIRT017377)

    Block miRNA regulation of human, mouse, rat TMEFF2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TMEFF2 (see all 27):
    hsa-miR-3689b hsa-miR-323-3p hsa-miR-495 hsa-miR-607 hsa-miR-4307 hsa-miR-429 hsa-miR-496 hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidTMEFF2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TMEFF2

    Gene Editing
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    eBioscience FlowRNA Probe Sets ( VA1-13784) for TMEFF2 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TEFF2_HUMAN, Q9UIK5: Isoform 1: Membrane; Single-pass type I membrane protein (Potential)
    TEFF2_HUMAN, Q9UIK5: Isoform 2: Membrane; Single-pass type I membrane protein (Potential)
    TEFF2_HUMAN, Q9UIK5: Isoform 3: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane3
    cytoskeleton1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0016021integral component of membrane NAS10903839

    Find genes that share ontologies with TMEFF2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TMEFF2 About    
    See pathways by source

    SuperPathContained pathways About
    1Validated targets of C-MYC transcriptional repression
    Validated targets of C-MYC transcriptional repression


    1 BioSystems Pathway for TMEFF2
        Validated targets of C-MYC transcriptional repression



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEFF2
    Interactions:

        GeneGlobe Interaction Network for TMEFF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for TMEFF2 (ENSP000002727714) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NEDD8ENSP000002504954STRING: ENSP00000250495
    UBA3ENSP000003543404STRING: ENSP00000354340
    MAXENSP000003514904STRING: ENSP00000351490
    MYCENSP000003672074STRING: ENSP00000367207
    UBE2MENSP000002530234STRING: ENSP00000253023
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMEFF2 (TEFF2)

    1 Novoseek inferred chemical compound relationship for TMEFF2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5-aza-2'deoxycytidine 66.3 9 19040536 (2), 15824739 (2), 12460892 (1), 16207479 (1)



    Find genes that share compounds with TMEFF2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TMEFF2 gene: 
    NM_016192.2  

    Unigene Cluster for TMEFF2:

    Transmembrane protein with EGF-like and two follistatin-like domains 2
    Hs.144513  [show with all ESTs]
    Unigene Representative Sequence: DQ133599
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000392314 ENST00000272771(uc002utc.3) ENST00000487771 ENST00000409056(uc002utd.1)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TMEFF2 (see all 27):
    hsa-miR-3689b hsa-miR-323-3p hsa-miR-495 hsa-miR-607 hsa-miR-4307 hsa-miR-429 hsa-miR-496 hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidTMEFF2 3' UTR sequence
    Inhib. RNA
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMEFF2
      QuantiTect SYBR Green Assays in human, mouse, rat TMEFF2
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    Additional mRNA sequence: 

    AB017269.1 AF179274.2 AF242222.1 AK054646.1 AK074507.1 AK074632.1 AK222691.1 AK315376.1 
    AL157430.1 AY358907.1 BC008973.1 CR457390.1 DQ133599.1 DQ668381.1 

    4 DOTS entries:

    DT.113235  DT.95170138  DT.120973908  DT.40245196 

    Selected AceView cDNA sequences (see all 79):

    AA297549 BC008973 AA535462 AK074632 AB004064 NM_016192 AK074507 AY358907 
    AB017269 CA488825 BP361764 AL157430 BP365060 CA395881 AF179274 BI458414 
    Z40989 BI602795 AF242222 AA236476 BI757477 BI915436 BI822104 BE855666 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMEFF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACTACAGCT
    TMEFF2 Expression
    About this image


    TMEFF2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Neurons
             Mature Horizontal Cells Inner Nuclear Layer
             Ventral/hypothalamic-like neurons
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Visceral White Adipocytes Visceral White Adipose
             HyStem+BMP4-induced SM30 cells
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Mature Horizontal Cells Inner Nuclear Layer
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Ventral/hypothalamic-like neurons
     
     Bone (Muscoskeletal System)
             HyStem+BMP4-induced SM30 cells
    TMEFF2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMEFF2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.144513

    UniProtKB/Swiss-Prot: TEFF2_HUMAN, Q9UIK5
    Tissue specificity: Highly expressed in adult and fetal brain, spinal cord and prostate. Expressed in all brain
    regions except the pituitary gland, with highest levels in amygdala and corpus callosum. Expressed in the
    pericryptal myofibroblasts and other stromal cells of normal colonic mucosa. Expressed in prostate carcinoma.
    Down-regulated in colorectal cancer. Present in Alzheimer disease plaques (at protein level). Isoform 3 is
    expressed weakly in testis and at high levels in normal and cancerous prostate

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TMEFF2 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmeff21 , 5 transmembrane protein with EGF-like and two follistatin-like more1, 5 93.49(n)1
    98.93(a)1
      1 (25.95 cM)5
    563631  NM_019790.41  NP_062764.11 
     509006475 
    chicken
    (Gallus gallus)
    Aves TMEFF21 transmembrane protein with EGF-like and two follistatin-like more 86.62(n)
    96.18(a)
      768542  XM_001231528.3  XP_001231529.2 
    lizard
    (Anolis carolinensis)
    Reptilia TMEFF26
    transmembrane protein with EGF-like and two follis...
    89(a)
    1 ↔ 1
    2(133180560-133529318)
    zebrafish
    (Danio rerio)
    Actinopterygii tmeff2b1 transmembrane protein with EGF-like and two follistatin-like more 66.98(n)
    68.13(a)
      797681  XM_005165745.1  XP_005165802.1 


    ENSEMBL Gene Tree for TMEFF2 (if available)
    TreeFam Gene Tree for TMEFF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TMEFF2 gene
    MSANTD3-TMEFF12  TMEFF12  
    2 SIMAP similar genes for TMEFF2 using alignment to 2 protein entries:     TEFF2_HUMAN (see all proteins):
    TMEFF1    SPINK1

    Find genes that share paralogs with TMEFF2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMEFF2 (see all 4697)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs710336451,2
    C--184687292(+) TCTTT-/T/TT  
            
    CTTTC
    1 -- int12NA 4
    rs106170411,2
    C--184695039(+) ttttt-/T/TT  
            
    agacc
    1 -- int11NA 2
    rs346486601,2
    C--184889879(+) GTCTC-/A/AAA 
            
    AAAAA
    1 -- int11NA 2
    rs676180541,2
    C--192270880(+) TTGTC-/CACTTGTA 1 -- int11Minor allele frequency- CAC:0.00NA 2
    rs754492611,2
    --192814262(+) ATGGAA/TTATAT 1 -- int10--------
    rs1896591201,2
    --192814411(+) TCCCTC/TCCCTT 1 -- int10--------
    rs1396030701,2
    --192814516(+) AAGATC/TGGAAA 1 -- int10--------
    rs1466948901,2
    C--192814594(+) ATCTT-/GGAATC 1 -- int10--------
    rs75866421,2
    C,F,H--192814629(+) TGTACA/GAACTA 1 -- int121Minor allele frequency- G:0.04NS EA NA WA CSA 1469
    rs1823252011,2
    --192814875(+) TATATC/GCATAC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TMEFF2 (192813769 - 193060435 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for TMEFF2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1001512CNV Deletion20482838
    esv268337CNV Insertion20981092
    esv274636CNV Insertion20981092
    esv272746CNV Insertion20981092
    esv269596CNV Insertion20981092
    esv1451304CNV Insertion17803354
    esv1367658CNV Insertion17803354
    nsv437307CNV Loss16327808
    nsv834495CNV Loss17160897
    nsv511831CNV Loss21212237

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605734    OMIM disorders: --


    Find genes that share disorders with TMEFF2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for TMEFF2 gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    polyposis 58.2 1 17352030 (1)
    polyps 52.1 2 12460892 (1), 12384516 (1)
    microsatellite instability 51.9 2 12384516 (1), 16152625 (1)
    colorectal cancer 48.7 9 16207479 (3), 12460892 (1), 16152625 (1), 17408633 (1)
    adenoma 44.2 7 17352030 (1), 12384516 (1), 16152625 (1)
    colorectal carcinoma 41.4 1 12460892 (1)
    prostate cancer 41.2 12 15805286 (4), 12729735 (1), 16439095 (1), 17942404 (1)
    dysplasia 38.3 5 12460892 (3), 17408633 (1)
    adenocarcinoma 32.2 2 12460892 (1), 12384516 (1)
    colitis ulcerative 22.9 2 12460892 (1)

    Genetic Association Database (GAD): TMEFF2
    Human Genome Epidemiology (HuGE) Navigator: TMEFF2 (3 documents)

    Export disorders for TMEFF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMEFF2 gene, integrated from 10 sources (see all 61):
    (articles sorted by number of sources associating them with TMEFF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of TMEFF2, a novel survival factor for hippocampal and mesencephalic neurons. (PubMed id 10903839)1, 2, 3 Horie M.... Tanigami A. (Genomics 2000)
    2. Phorbol ester-induced shedding of the prostate cancer marker transmembrane protein with epidermal growth factor and two follistatin motifs 2 is mediated by the disintegrin and metalloproteinase-17. (PubMed id 17942404)1, 2, 9 Ali N. and Knaeuper V. (J. Biol. Chem. 2007)
    3. A novel epidermal growth factor-like molecule containing two follistatin modules stimulates tyrosine phosphorylation of erbB-4 in MKN28 gastric cancer cells. (PubMed id 10600548)1, 2, 9 Uchida T.... Sakamoto C. (Biochem. Biophys. Res. Commun. 1999)
    4. The gene for a novel transmembrane protein containing epidermal growth factor and follistatin domains is frequently hypermethylated in human tumor cells. (PubMed id 10987305)1, 2, 9 Liang G.... Jones P.A. (Cancer Res. 2000)
    5. A truncated isoform of TMEFF2 encodes a secreted protein in prostate cancer cells. (PubMed id 16439095)1, 2, 9 Quayle S.N. and Sadar M.D. (Genomics 2006)
    6. GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. (PubMed id 21658281)1, 4 Aouizerat B.E....Tseng Z.H. (BMC Cardiovasc Disord 2011)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    8. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    9. Genome-wide association with diabetes-related traits in the Framingham Heart Study. (PubMed id 17903298)1, 4 Meigs J.B....Dupuis J. (BMC Med. Genet. 2007)
    10. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23671 HGNC: 11867 AceView: TMEFF2 Ensembl:ENSG00000144339 euGenes: HUgn23671
    ECgene: TMEFF2 H-InvDB: TMEFF2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TMEFF2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TMEFF2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMEFF2 gene:
    Search GeneIP for patents involving TMEFF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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