Aliases for TMEFF2 Gene
External Ids for TMEFF2 Gene
Previous GeneCards Identifiers for TMEFF2 Gene
This gene encodes a member of the tomoregulin family of transmembrane proteins. This protein has been shown to function as both an oncogene and a tumor suppressor depending on the cellular context and may regulate prostate cancer cell invasion. Multiple soluble forms of this protein have been identified that arise from both an alternative splice variant and ectodomain shedding. Additionally, this gene has been found to be hypermethylated in multiple cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
GeneCards Summary for TMEFF2 Gene
TMEFF2 (Transmembrane Protein With EGF-Like And Two Follistatin-Like Domains 2) is a Protein Coding gene. Diseases associated with TMEFF2 include colon mucinous adenocarcinoma and colorectal cancer. Among its related pathways are Validated targets of C-MYC transcriptional repression. An important paralog of this gene is TMEFF1.
UniProtKB/Swiss-Prot for TMEFF2 Gene
May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation.