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Aliases for TMEFF2 Gene

Aliases for TMEFF2 Gene

  • Transmembrane Protein With EGF-Like And Two Follistatin-Like Domains 2 2 3
  • HPP1 3 4 6
  • Hyperplastic Polyposis Protein 1 3 4
  • Transmembrane Protein TENB2 2 3
  • Tomoregulin 2 3
  • TENB2 3 4
  • TPEF 3 4
  • TR-2 3 4
  • TR 3 6
  • Transmembrane Protein With EGF-Like And Two Follistatin-Like Domains 4
  • Cancer/Testis Antigen Family 120, Member 2 3
  • Cancer/Testis Antigen Family 120 2
  • Tomoregulin-2 3
  • Member 2 2
  • CT120.2 3

External Ids for TMEFF2 Gene

Summaries for TMEFF2 Gene

Entrez Gene Summary for TMEFF2 Gene

  • This gene encodes a member of the tomoregulin family of transmembrane proteins. This protein has been shown to function as both an oncogene and a tumor suppressor depending on the cellular context and may regulate prostate cancer cell invasion. Multiple soluble forms of this protein have been identified that arise from both an alternative splice variant and ectodomain shedding. Additionally, this gene has been found to be hypermethylated in multiple cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

GeneCards Summary for TMEFF2 Gene

TMEFF2 (Transmembrane Protein With EGF-Like And Two Follistatin-Like Domains 2) is a Protein Coding gene. Diseases associated with TMEFF2 include crohns colitis. Among its related pathways are Validated targets of C-MYC transcriptional repression. An important paralog of this gene is TMEFF1.

UniProtKB/Swiss-Prot for TMEFF2 Gene

  • May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation.

Gene Wiki entry for TMEFF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEFF2 Gene

Genomics for TMEFF2 Gene

Genomic Location for TMEFF2 Gene

Start:
191,949,043 bp from pter
End:
192,195,709 bp from pter
Size:
246,667 bases
Orientation:
Minus strand

Genomic View for TMEFF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEFF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEFF2 Gene

Regulatory Elements for TMEFF2 Gene

Proteins for TMEFF2 Gene

  • Protein details for TMEFF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UIK5-TEFF2_HUMAN
    Recommended name:
    Tomoregulin-2
    Protein Accession:
    Q9UIK5
    Secondary Accessions:
    • Q2FA44
    • Q4ZFW4
    • Q53H90
    • Q53RE1
    • Q8N2R5
    • Q9NR15
    • Q9NSS5
    • Q9P2Y9
    • Q9UK65

    Protein attributes for TMEFF2 Gene

    Size:
    374 amino acids
    Molecular mass:
    41428 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA90820.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Mitochondrial contamination starting in position 361.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TMEFF2 Gene

    Alternative splice isoforms for TMEFF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEFF2 Gene

Proteomics data for TMEFF2 Gene at MOPED

Post-translational modifications for TMEFF2 Gene

  • A soluble form (TMEFF2-ECD) is produced by proteolytic shedding. This shedding can be induced by phorbol ester or proinflammatory cytokines such as TNFalpha, and is mediated by ADAM17
  • N-glycosylated. Contains chondroitin sulfate glycosaminoglycans.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn55, Asn204, and Asn230

Other Protein References for TMEFF2 Gene

No data available for DME Specific Peptides for TMEFF2 Gene

Domains for TMEFF2 Gene

Protein Domains for TMEFF2 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

TEFF2_HUMAN
Domain:
  • Contains 1 EGF-like domain.:
    • Q9UIK5
  • Contains 2 Kazal-like domains.:
    • Q9UIK5
Family:
  • Belongs to the tomoregulin family.:
    • Q9UIK5
genes like me logo Genes that share domains with TMEFF2: view

No data available for Gene Families for TMEFF2 Gene

Function for TMEFF2 Gene

Molecular function for TMEFF2 Gene

UniProtKB/Swiss-Prot Function: May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation.
UniProtKB/Swiss-Prot Induction: Down-regulated in tumor cell lines in response to a high level of methylation in the 5 region. The CpG island methylation correlates with TMEFF2 silencing in tumor cell lines.

Gene Ontology (GO) - Molecular Function for TMEFF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TMEFF2: view
genes like me logo Genes that share phenotypes with TMEFF2: view

miRNA for TMEFF2 Gene

miRTarBase miRNAs that target TMEFF2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEFF2 Gene

Localization for TMEFF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEFF2 Gene

Isoform 1: Membrane; Single-pass type I membrane protein.
Isoform 2: Membrane; Single-pass type I membrane protein.
Isoform 3: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEFF2 Gene COMPARTMENTS Subcellular localization image for TMEFF2 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for TMEFF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0016021 integral component of membrane NAS 10903839
genes like me logo Genes that share ontologies with TMEFF2: view

Pathways for TMEFF2 Gene

genes like me logo Genes that share pathways with TMEFF2: view

Pathways by source for TMEFF2 Gene

1 BioSystems pathway for TMEFF2 Gene

Interacting Proteins for TMEFF2 Gene

Gene Ontology (GO) - Biological Process for TMEFF2 Gene

None

Compounds for TMEFF2 Gene

(1) Novoseek inferred chemical compound relationships for TMEFF2 Gene

Compound -log(P) Hits PubMed IDs
5-aza-2deoxycytidine 66.3 6
genes like me logo Genes that share compounds with TMEFF2: view

Transcripts for TMEFF2 Gene

Unigene Clusters for TMEFF2 Gene

Transmembrane protein with EGF-like and two follistatin-like domains 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEFF2 Gene

No ASD Table

Relevant External Links for TMEFF2 Gene

GeneLoc Exon Structure for
TMEFF2
ECgene alternative splicing isoforms for
TMEFF2

Expression for TMEFF2 Gene

mRNA expression in normal human tissues for TMEFF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEFF2 Gene

This gene is overexpressed in Brain - Hypothalamus (5.2), Brain - Anterior cingulate cortex (BA24) (4.9), Brain - Amygdala (4.9), Brain - Cortex (4.5), Brain - Hippocampus (4.5), Brain - Frontal Cortex (BA9) (4.3), and Brain - Substantia nigra (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TMEFF2 Gene

SOURCE GeneReport for Unigene cluster for TMEFF2 Gene Hs.144513

mRNA Expression by UniProt/SwissProt for TMEFF2 Gene

Q9UIK5-TEFF2_HUMAN
Tissue specificity: Highly expressed in adult and fetal brain, spinal cord and prostate. Expressed in all brain regions except the pituitary gland, with highest levels in amygdala and corpus callosum. Expressed in the pericryptal myofibroblasts and other stromal cells of normal colonic mucosa. Expressed in prostate carcinoma. Down-regulated in colorectal cancer. Present in Alzheimer disease plaques (at protein level). Isoform 3 is expressed weakly in testis and at high levels in normal and cancerous prostate.
genes like me logo Genes that share expressions with TMEFF2: view

Orthologs for TMEFF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEFF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEFF2 36
  • 99.91 (n)
  • 100 (a)
TMEFF2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEFF2 36
  • 94.92 (n)
  • 99.47 (a)
TMEFF2 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEFF2 36
  • 92.87 (n)
  • 96.52 (a)
TMEFF2 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmeff2 36
  • 93.49 (n)
  • 98.93 (a)
Tmeff2 16
Tmeff2 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEFF2 37
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEFF2 37
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEFF2 36
  • 86.62 (n)
  • 96.18 (a)
TMEFF2 37
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEFF2 37
  • 89 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tmeff2a 37
  • 65 (a)
OneToMany
tmeff2b 36
  • 66.98 (n)
  • 68.13 (a)
tmeff2b 37
  • 58 (a)
OneToMany
Species with no ortholog for TMEFF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEFF2 Gene

ENSEMBL:
Gene Tree for TMEFF2 (if available)
TreeFam:
Gene Tree for TMEFF2 (if available)

Paralogs for TMEFF2 Gene

Paralogs for TMEFF2 Gene

Selected SIMAP similar genes for TMEFF2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TMEFF2: view

Variants for TMEFF2 Gene

Sequence variations from dbSNP and Humsavar for TMEFF2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1110294 -- 192,169,764(-) CAGCA(C/G)ACTCT intron-variant
rs1113932 -- 192,187,627(+) AAGAC(C/T)CAAGT intron-variant
rs1137722 -- 192,150,985(-) GACAC(A/G)TGGGG intron-variant
rs1141685 -- 191,953,978(+) cgcct(C/G)ccggg intron-variant
rs1806647 -- 192,124,465(+) TGGCA(G/T)AAGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEFF2 Gene

Variant ID Type Subtype PubMed ID
esv274636 CNV Insertion 20981092
esv268337 CNV Insertion 20981092
esv1367658 CNV Insertion 17803354
nsv834495 CNV Loss 17160897
esv272746 CNV Insertion 20981092
esv1001512 CNV Deletion 20482838
esv269596 CNV Insertion 20981092
esv1451304 CNV Insertion 17803354
nsv437307 CNV Loss 16327808
nsv511831 CNV Loss 21212237

Relevant External Links for TMEFF2 Gene

HapMap Linkage Disequilibrium report
TMEFF2

Disorders for TMEFF2 Gene

(1) MalaCards Diseases for TMEFF2 Gene

Search for TMEFF2 Gene in MalaCards »

(15) Novoseek inferred disease relationships for TMEFF2 Gene

Disease -log(P) Hits PubMed IDs
polyposis 58.2 1
polyps 52.1 2
microsatellite instability 51.9 2
colorectal cancer 48.7 6
adenoma 44.2 3

Relevant External Links for TMEFF2

Genetic Association Database (GAD)
TMEFF2
Human Genome Epidemiology (HuGE) Navigator
TMEFF2
genes like me logo Genes that share disorders with TMEFF2: view

No data available for UniProtKB/Swiss-Prot for TMEFF2 Gene

Publications for TMEFF2 Gene

  1. A novel epidermal growth factor-like molecule containing two follistatin modules stimulates tyrosine phosphorylation of erbB-4 in MKN28 gastric cancer cells. (PMID: 10600548) Uchida T. … Sakamoto C. (Biochem. Biophys. Res. Commun. 1999) 3 4 23
  2. The gene for a novel transmembrane protein containing epidermal growth factor and follistatin domains is frequently hypermethylated in human tumor cells. (PMID: 10987305) Liang G. … Jones P.A. (Cancer Res. 2000) 3 4 23
  3. A truncated isoform of TMEFF2 encodes a secreted protein in prostate cancer cells. (PMID: 16439095) Quayle S.N. … Sadar M.D. (Genomics 2006) 3 4 23
  4. Identification and characterization of TMEFF2, a novel survival factor for hippocampal and mesencephalic neurons. (PMID: 10903839) Horie M. … Tanigami A. (Genomics 2000) 2 3 4
  5. Phorbol ester-induced shedding of the prostate cancer marker transmembrane protein with epidermal growth factor and two follistatin motifs 2 is mediated by the disintegrin and metalloproteinase-17. (PMID: 17942404) Ali N. … Knaeuper V. (J. Biol. Chem. 2007) 3 4 23

Products for TMEFF2 Gene

  • antibodies-online proteins for TMEFF2
  • antibodies-online antibodies for TMEFF2
  • antibodies-online kits for TMEFF2

Sources for TMEFF2 Gene

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