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Aliases for TMEFF2 Gene

Aliases for TMEFF2 Gene

  • Transmembrane Protein With EGF Like And Two Follistatin Like Domains 2 2 3
  • Transmembrane Protein With EGF-Like And Two Follistatin-Like Domains 2 2 3 5
  • Hyperplastic Polyposis Protein 1 3 4
  • Transmembrane Protein TENB2 2 3
  • Tomoregulin 2 3
  • TENB2 3 4
  • HPP1 3 4
  • TPEF 3 4
  • TR-2 3 4
  • Transmembrane Protein With EGF-Like And Two Follistatin-Like Domains 4
  • Cancer/Testis Antigen Family 120, Member 2 3
  • Cancer/Testis Antigen Family 120 2
  • Member 2 2
  • CT120.2 3
  • TR 3

External Ids for TMEFF2 Gene

Previous GeneCards Identifiers for TMEFF2 Gene

  • GC02M190998
  • GC02M191517
  • GC02M192777
  • GC02M193017
  • GC02M192640
  • GC02M192522
  • GC02M184672

Summaries for TMEFF2 Gene

Entrez Gene Summary for TMEFF2 Gene

  • This gene encodes a member of the tomoregulin family of transmembrane proteins. This protein has been shown to function as both an oncogene and a tumor suppressor depending on the cellular context and may regulate prostate cancer cell invasion. Multiple soluble forms of this protein have been identified that arise from both an alternative splice variant and ectodomain shedding. Additionally, this gene has been found to be hypermethylated in multiple cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

GeneCards Summary for TMEFF2 Gene

TMEFF2 (Transmembrane Protein With EGF Like And Two Follistatin Like Domains 2) is a Protein Coding gene. Diseases associated with TMEFF2 include Colorectal Cancer and Glass Syndrome. Among its related pathways are Validated targets of C-MYC transcriptional repression. An important paralog of this gene is TMEFF1.

UniProtKB/Swiss-Prot for TMEFF2 Gene

  • May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation.

Gene Wiki entry for TMEFF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEFF2 Gene

Genomics for TMEFF2 Gene

Regulatory Elements for TMEFF2 Gene

Enhancers for TMEFF2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMEFF2 on UCSC Golden Path with GeneCards custom track

Promoters for TMEFF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEFF2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEFF2 Gene

191,949,043 bp from pter
192,195,709 bp from pter
246,667 bases
Minus strand

Genomic View for TMEFF2 Gene

Genes around TMEFF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEFF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEFF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEFF2 Gene

Proteins for TMEFF2 Gene

  • Protein details for TMEFF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q2FA44
    • Q4ZFW4
    • Q53H90
    • Q53RE1
    • Q8N2R5
    • Q9NR15
    • Q9NSS5
    • Q9P2Y9
    • Q9UK65

    Protein attributes for TMEFF2 Gene

    374 amino acids
    Molecular mass:
    41428 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA90820.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Mitochondrial contamination starting in position 361.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TMEFF2 Gene

    Alternative splice isoforms for TMEFF2 Gene


neXtProt entry for TMEFF2 Gene

Proteomics data for TMEFF2 Gene at MOPED

Post-translational modifications for TMEFF2 Gene

  • A soluble form (TMEFF2-ECD) is produced by proteolytic shedding. This shedding can be induced by phorbol ester or proinflammatory cytokines such as TNFalpha, and is mediated by ADAM17.
  • N-glycosylated. Contains chondroitin sulfate glycosaminoglycans.
  • Glycosylation at Asn 55, Asn 204, and Asn 230
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEFF2 Gene

Antibody Products

  • R&D Systems Antibodies for TMEFF2 (TMEFF2/Tomoregulin-2)
  • Cloud-Clone Corp. Antibodies for TMEFF2

No data available for DME Specific Peptides for TMEFF2 Gene

Domains & Families for TMEFF2 Gene

Protein Domains for TMEFF2 Gene


Suggested Antigen Peptide Sequences for TMEFF2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 EGF-like domain.
  • Belongs to the tomoregulin family.
  • Contains 1 EGF-like domain.
  • Contains 2 Kazal-like domains.
  • Belongs to the tomoregulin family.
genes like me logo Genes that share domains with TMEFF2: view

No data available for Gene Families for TMEFF2 Gene

Function for TMEFF2 Gene

Molecular function for TMEFF2 Gene

UniProtKB/Swiss-Prot Function:
May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation.
UniProtKB/Swiss-Prot Induction:
Down-regulated in tumor cell lines in response to a high level of methylation in the 5 region. The CpG island methylation correlates with TMEFF2 silencing in tumor cell lines.
genes like me logo Genes that share phenotypes with TMEFF2: view

Animal Models for TMEFF2 Gene

MGI Knock Outs for TMEFF2:

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEFF2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEFF2 Gene

Localization for TMEFF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEFF2 Gene

Isoform 1: Membrane; Single-pass type I membrane protein.
Isoform 2: Membrane; Single-pass type I membrane protein.
Isoform 3: Secreted.

Subcellular locations from

Jensen Localization Image for TMEFF2 Gene COMPARTMENTS Subcellular localization image for TMEFF2 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytoskeleton 2

No data available for Gene Ontology (GO) - Cellular Components for TMEFF2 Gene

Pathways & Interactions for TMEFF2 Gene

genes like me logo Genes that share pathways with TMEFF2: view

Pathways by source for TMEFF2 Gene

1 BioSystems pathway for TMEFF2 Gene

Interacting Proteins for TMEFF2 Gene

Gene Ontology (GO) - Biological Process for TMEFF2 Gene


No data available for SIGNOR curated interactions for TMEFF2 Gene

Drugs & Compounds for TMEFF2 Gene

(1) Additional Compounds for TMEFF2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TMEFF2: view

Transcripts for TMEFF2 Gene

Unigene Clusters for TMEFF2 Gene

Transmembrane protein with EGF-like and two follistatin-like domains 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEFF2 Gene

No ASD Table

Relevant External Links for TMEFF2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEFF2 Gene

mRNA expression in normal human tissues for TMEFF2 Gene

mRNA differential expression in normal tissues according to GTEx for TMEFF2 Gene

This gene is overexpressed in Brain - Hypothalamus (x5.2), Brain - Anterior cingulate cortex (BA24) (x4.9), Brain - Amygdala (x4.9), Brain - Cortex (x4.5), Brain - Hippocampus (x4.5), Brain - Frontal Cortex (BA9) (x4.3), and Brain - Substantia nigra (x4.1).

Protein differential expression in normal tissues from HIPED for TMEFF2 Gene

This gene is overexpressed in Frontal cortex (44.5) and Fetal Brain (24.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMEFF2 Gene

SOURCE GeneReport for Unigene cluster for TMEFF2 Gene Hs.144513

mRNA Expression by UniProt/SwissProt for TMEFF2 Gene

Tissue specificity: Highly expressed in adult and fetal brain, spinal cord and prostate. Expressed in all brain regions except the pituitary gland, with highest levels in amygdala and corpus callosum. Expressed in the pericryptal myofibroblasts and other stromal cells of normal colonic mucosa. Expressed in prostate carcinoma. Down-regulated in colorectal cancer. Present in Alzheimer disease plaques (at protein level). Isoform 3 is expressed weakly in testis and at high levels in normal and cancerous prostate.
genes like me logo Genes that share expression patterns with TMEFF2: view

Protein tissue co-expression partners for TMEFF2 Gene

- Elite partner

Primer Products

Orthologs for TMEFF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEFF2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMEFF2 35
  • 94.92 (n)
  • 99.47 (a)
  • 99 (a)
(Canis familiaris)
Mammalia TMEFF2 35
  • 92.87 (n)
  • 96.52 (a)
  • 97 (a)
(Mus musculus)
Mammalia Tmeff2 35
  • 93.49 (n)
  • 98.93 (a)
Tmeff2 16
Tmeff2 36
  • 99 (a)
(Pan troglodytes)
Mammalia TMEFF2 35
  • 99.91 (n)
  • 100 (a)
  • 100 (a)
(Monodelphis domestica)
Mammalia TMEFF2 36
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia TMEFF2 36
  • 67 (a)
(Gallus gallus)
Aves TMEFF2 35
  • 86.62 (n)
  • 96.18 (a)
  • 87 (a)
(Anolis carolinensis)
Reptilia TMEFF2 36
  • 89 (a)
(Danio rerio)
Actinopterygii tmeff2b 35
  • 66.98 (n)
  • 68.13 (a)
tmeff2a 36
  • 65 (a)
tmeff2b 36
  • 58 (a)
Species with no ortholog for TMEFF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEFF2 Gene

Gene Tree for TMEFF2 (if available)
Gene Tree for TMEFF2 (if available)

Paralogs for TMEFF2 Gene

Paralogs for TMEFF2 Gene

(2) SIMAP similar genes for TMEFF2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TMEFF2: view

Variants for TMEFF2 Gene

Sequence variations from dbSNP and Humsavar for TMEFF2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1806647 -- 192,124,465(+) TGGCA(G/T)AAGTG intron-variant
rs1806733 -- 192,169,957(-) GTGGG(G/T)TGATA intron-variant
rs2884024 -- 192,078,240(+) CATCA(C/T)CTGTA intron-variant
rs2884025 -- 192,079,118(+) AAGCC(A/G)AGGCC intron-variant
rs2884026 -- 192,065,634(+) TCTTG(A/G)TAGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEFF2 Gene

Variant ID Type Subtype PubMed ID
esv274636 CNV Insertion 20981092
esv268337 CNV Insertion 20981092
esv1367658 CNV Insertion 17803354
nsv834495 CNV Loss 17160897
esv272746 CNV Insertion 20981092
esv1001512 CNV Deletion 20482838
esv269596 CNV Insertion 20981092
esv1451304 CNV Insertion 17803354
nsv437307 CNV Loss 16327808
nsv511831 CNV Loss 21212237

Variation tolerance for TMEFF2 Gene

Residual Variation Intolerance Score: 28.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.35; 41.78% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TMEFF2 Gene

Disorders for TMEFF2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for TMEFF2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
colorectal cancer
  • colorectal cancer, somatic
glass syndrome
  • chromosome 2q32-q33 deletion syndrome
prostate cancer
  • prostate cancer, hereditary, 5
colon mucinous adenocarcinoma
  • colonic mucinous adenocarcinoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TMEFF2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TMEFF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEFF2 Gene

Publications for TMEFF2 Gene

  1. Identification and characterization of TMEFF2, a novel survival factor for hippocampal and mesencephalic neurons. (PMID: 10903839) Horie M. … Tanigami A. (Genomics 2000) 2 3 4 67
  2. Aberrant promoter methylation of the TPEF gene in esophageal squamous cell carcinoma. (PMID: 19040536) Zhao B.J. … Ma X. (Dis. Esophagus 2008) 3 23
  3. Detection of aberrant methylation in fecal DNA as a molecular screening tool for colorectal cancer and precancerous lesions. (PMID: 17352030) Huang Z.H. … Wang J.F. (World J. Gastroenterol. 2007) 3 23
  4. Phorbol ester-induced shedding of the prostate cancer marker transmembrane protein with epidermal growth factor and two follistatin motifs 2 is mediated by the disintegrin and metalloproteinase-17. (PMID: 17942404) Ali N. … Knaeuper V. (J. Biol. Chem. 2007) 3 23
  5. A truncated isoform of TMEFF2 encodes a secreted protein in prostate cancer cells. (PMID: 16439095) Quayle S.N. … Sadar M.D. (Genomics 2006) 3 23

Products for TMEFF2 Gene

Sources for TMEFF2 Gene