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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMEFF1 Gene

protein-coding   GIFtS: 49
GCID: GC09P103235

transmembrane protein with EGF-like and two follistatin-like...


(Previous symbol: C9orf2)
 Explore 3 diseases affiliated with
TMEFF1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TMEFF1    

Aliases
for TMEFF1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Transmembrane Protein With EGF-Like And Two Follistatin-Like Domains 11 2     TR-12 3
C9orf21 2 3     Cancer/Testis Antigen Family 120, Member 12
H73651 2 3     Tomoregulin-11
CT120.11 2     C9ORF25
Transmembrane Protein With EGF-Like And One Follistatin-Like Domain2 3     

External Ids:    HGNC: 118661   Entrez Gene: 85772   Ensembl: ENSG000002416977   OMIM: 6034215   UniProtKB: Q8IYR63   

Export aliases for TMEFF1 gene to outside databases

Previous GC identifers: GC09P094036 GC09P094979 GC09P096693 GC09P098584 GC09P098570 GC09P100284 GC09P100315 GC09P102230 GC09P103204 GC09P072834


Summaries
for TMEFF1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: TEFF1_HUMAN, Q8IYR6
Function: May inhibit NODAL and BMP signaling during neural patterning (By similarity). May be a tumor suppressor in
brain cancers




Genomic Views
for TMEFF1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMEFF1 gene promoter:
         Max1   STAT1   Spz1   Pax-5   p300   FOXD1   STAT1beta   STAT1alpha   Pax-4a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TMEFF1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMEFF1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEFF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q31   Ensembl cytogenetic band:  9q31.1   HGNC cytogenetic band: 9q31

TMEFF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEFF1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P103235:  view genomic region     (about GC identifiers)

Start:
 103,204,560 bp from pter      End:
 103,339,918 bp from pter
Size:
 135,359 bases      Orientation:
 plus strand

Proteins
for TMEFF1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TEFF1_HUMAN, Q8IYR6 (See protein sequence)
Recommended Name: Tomoregulin-1 precursor  
Size: 380 amino acids; 40934 Da
Subunit: May interact with ST14
Subcellular location: Cell membrane; Single-pass type I membrane protein
Sequence caution: Sequence=AAA64622.1; Type=Frameshift; Positions=293, 297; Sequence=CAA58791.1; Type=Frameshift;
Positions=293, 297;
Secondary accessions: Q13086 Q8N3T8
Alternative splicing: 2 isoforms:  Q8IYR6-1   Q8IYR6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TMEFF1: NX_Q8IYR6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8IYR6

    • TMEFF1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003683.2  
    ENSEMBL proteins: 
     ENSP00000364013   ENSP00000334447  

    Human Recombinant Protein Products: 
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    Browse Proteins at Uscn

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--


    TMEFF1 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for TMEFF1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TMEFF1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR002350 Prot_inh_Kazal
     IPR000742 EG-like_dom
     IPR013032 EGF-like_CS
     IPR011497 Kazal-type_dom

    Graphical View of Domain Structure for InterPro Entry Q8IYR6

    ProtoNet protein and cluster: Q8IYR6

    1 Blocks protein family: IPB006210 Type I EGF

    UniProtKB/Swiss-Prot: TEFF1_HUMAN, Q8IYR6
    Similarity: Belongs to the tomoregulin family
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 2 Kazal-like domains


    Function
    for TMEFF1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TEFF1_HUMAN, Q8IYR6
    Function: May inhibit NODAL and BMP signaling during neural patterning (By similarity). May be a tumor suppressor in
    brain cancers

         Genatlas biochemistry entry for TMEFF1:
    transmembrane protein with an EGF-like domain and two follistatin modules in the extra-cellular region

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMEFF1
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate TMEFF1 (see all 20):
    hsa-miR-30c hsa-miR-3607-3p hsa-miR-128 hsa-miR-30d hsa-miR-138-2* hsa-miR-373* hsa-miR-570 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmid: TMEFF1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEFF1 (see all 7)
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    Gene Editing
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEFF1 

    Cell Line
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    In Situ Assay
    Products:       
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    1 GenomeRNAi human phenotype for TMEFF1:
     Synthetic lethal with imatinib 


    Pathways & Interactions
    for TMEFF1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEFF1

    1 Interacting protein for TMEFF1 (Q8IYR63) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAC1P630003I2D: score=2 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development IEA--


    TMEFF1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TMEFF1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMEFF1
    Search CenterWatch for drugs/clinical trials and news about TMEFF1 / TEFF1 

    Transcripts
    for TMEFF1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TMEFF1 gene: 
    NM_003692.4  

    Unigene Cluster for TMEFF1:

    Transmembrane protein with EGF-like and two follistatin-like domains 1
    Hs.598100  [show with all ESTs]
    Unigene Representative Sequence: NM_003692
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374879(uc004baz.2) ENST00000334943

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMEFF1
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate TMEFF1 (see all 20):
    hsa-miR-30c hsa-miR-3607-3p hsa-miR-128 hsa-miR-30d hsa-miR-138-2* hsa-miR-373* hsa-miR-570 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmid: TMEFF1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEFF1 (see all 7)
    OriGene shRNA RFP: TMEFF1
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEFF1
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEFF1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEFF1

    Additional cDNA sequence: 

    BC021991.1 BC035056.1 

    4 DOTS entries:

    DT.440817  DT.100750187  DT.95366242  DT.121152621 

    24/207 AceView cDNA sequences (see all 207):

    BE301701 AA084788 AI240420 CR616245 BM718343 BM841942 NM_080655 BG033503 
    BE301253 BM854314 CR608769 AI623842 AI288886 R53268 CA425719 AA193462 
    AL831919 BQ776266 BM857515 AI718525 BM559008 CD365253 AW148791 AA373648 

    GeneLoc Exon Structure


    Expression
    for TMEFF1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMEFF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTATAATATA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TMEFF1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Sclerotome cells (Primary Cell)Bone, Cartilage, Somite
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TMEFF1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMEFF1

    SOURCE GeneReport for Unigene cluster: Hs.598100

    UniProtKB/Swiss-Prot: TEFF1_HUMAN, Q8IYR6
    Tissue specificity: Expressed predominantly in brain, and at lower levels in heart, placenta and skeletal muscle.
    Down-regulated in brain tumors as compared to control brain tissues

        SABiosciences Expression via Pathway-Focused PCR Array including TMEFF1: 
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for TMEFF1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TMEFF1 gene from 7/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Tmeff11 , 5 transmembrane protein with EGF-like and two follistatin-like domains 1 less1, 5 88.29(n)1
    95.68(a)1    		   4 (26.15 cM)5
    2301571  NM_021436.21  NP_067411.11 
     485851745 
    chicken
    (Gallus gallus)    		 Aves C9ORF306
    		 Uncharacterized protein
    		 92(a)
    		 1 → many
    		 2(91008722-91058440)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 92(a)
    		 1 → many
    		 4(67789842-67812921)
    African clawed frog
    (Xenopus laevis)    		 Amphibia orf2 X.laevis mRNA for transmembrane protein containing an EGF domain less 79.84(n)    U19879.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii si:ch211-39l18.56
    tmeff16
    		 si:ch211-39l18.5
    transmembrane protein with EGF-like and two follis...
    		 52(a)
    52(a)
    		 many ↔ many
    many ↔ many
    		 2(42278040-42288236)
    24(34971180-35018379)
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG323546
    		 --
    		 10(a)
    		 possible ortholog
    		 3L(8408957-8415305)
    worm
    (Caenorhabditis elegans)    		 Secernentea F29G6.16
    ZK813.66
    		 --
    		 5(a)
    12(a)
    		 possible ortholog
    many → 1
    		 X(11502396-11509364)
    X(3424803-3427324)


    ENSEMBL Gene Tree for TMEFF1 (if available)
    TreeFam Gene Tree for TMEFF1 (if available) 

    Paralogs
    for TMEFF1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TMEFF1 gene
    MSANTD3-TMEFF12  TGFA2  BTC2  TMEFF22  
    1 SIMAP similar gene for TMEFF1 using alignment to 1 protein entry:     TEFF1_HUMAN:
    TMEFF2

    TMEFF1 for paralogs           About GeneDecksing



    Genomic Variants
    for TMEFF1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1564 NCBI SNPs in TMEFF1 are shown (see all 1564)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 9 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs105491051,2
    		C--72875666(+) AAAAA-/AACAAAA 1 -- int12Minor allele frequency- AA:0.25NA 4
    rs1152780711,2
    		F,--103233523(+) TTATAG/AGTAAT 2 -- int1 us2k11Minor allele frequency- A:0.04WA 118
    rs1175019051,2
    		F,--103233714(+) CATTGT/CTAAAG 2 -- us2k1 int11Minor allele frequency- C:0.03EA 120
    rs1143095301,2
    		F,--103233751(+) GGTACC/TGTACT 2 -- us2k1 int11Minor allele frequency- T:0.03WA 118
    rs1389055901,2
    		--103233844(+) ATCCTG/TTAGAT 2 -- int1 us2k10--------
    rs1502206321,2
    		--103234008(+) TGTGC-/GTGTGTG 2 -- int1 us2k10--------
    rs1493765161,2
    		--103234087(+) CCTCTA/TCCTCC 2 -- int1 us2k10--------
    rs1807263041,2
    		--103234157(+) GGTGCA/GCGCCA 2 -- us2k1 int10--------
    rs1447079471,2
    		--103234159(+) TGCGCA/GCCACC 2 -- us2k1 int10--------
    rs715076841,2
    		C,F,--103234234(+) TCGAAG/CTCCTG 2 -- int1 us2k12Minor allele frequency- C:0.50NA 4

    HapMap Linkage Disequilibrium report for TMEFF1 (103204560 - 103339918 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TMEFF1: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEFF1
    DNA2.0 Custom Variant and Variant Library Synthesis for TMEFF1

    Disorders / Diseases
    for TMEFF1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TMEFF1 for disorders           About GeneDecksing

    OMIM gene information: 603421    OMIM disorders: --

    3 diseases for TMEFF1:    About MalaCards
    cleft lip/palate    cleft lip    brain cancer

    Human Genome Epidemiology (HuGE) Navigator: TMEFF1 (1 document)

    Export disorders for TMEFF1 gene to outside databases

    Publications
    for TMEFF1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMEFF1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TMEFF1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. TMEFF1 and brain tumors. (PubMed id 12743596)1, 2 Gery S.... Koeffler H.P. (2003)
    2. Assignment1 of H7365 (C9orf2) to human chromosome band 9q31 by somatic cell hybrid analysis and fluorescence in situ hybridization. (PubMed id 9730596)1, 3 Eib D.W....Cremers F.P. (1998)
    3. A novel transmembrane protein with epidermal growth factor and follistatin domains expressed in the hypothalamo-hypophysial axis of Xenopus laevis. (PubMed id 8752111)1, 2 Eib D.W. and Martens G.J.M. (1996)
    4. Protein interaction analysis of ST14 domains and their point and deletion mutants. (PubMed id 16407223)2, 9 Ge W.... Zheng S. (2006)
    5. Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate. (PubMed id 20583170)1 Letra A....Vieira A.R. (2010)
    6. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    8. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (2004)
    9. Tomoregulin-1 (TMEFF1) inhibits nodal signaling through direct binding to the nodal coreceptor Cripto. (PubMed id 14563676)1 Harms P.W. and Chang C. (2003)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for TMEFF1 gene

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    Genome Databases showing TMEFF1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8577 HGNC: 11866 AceView: TMEFF1andMGC17337 Ensembl:ENSG00000241697 euGenes: HUgn8577
    ECgene: TMEFF1 H-InvDB: TMEFF1

    Other Databases showing TMEFF1 gene

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    Specialized Databases showing TMEFF1 gene

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    PharmGKB entry for TMEFF1 Pharmacogenomics, SNPs, Pathways

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