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Aliases for TMED9 Gene

Aliases for TMED9 Gene

  • Transmembrane Emp24 Protein Transport Domain Containing 9 2 3
  • P24 Family Protein Alpha-2 3 4
  • Glycoprotein 25L2 3 4
  • P24alpha2 3 4
  • GMP25 3 4
  • P25 3 4
  • Transmembrane Emp24 Domain-Containing Protein 9 3
  • Gp25L2 Protein 3
  • HSGP25L2G 3
  • GP25L2 4

External Ids for TMED9 Gene

Previous GeneCards Identifiers for TMED9 Gene

  • GC05P176952
  • GC05P171938
  • GC05P177019

Summaries for TMED9 Gene

GeneCards Summary for TMED9 Gene

TMED9 (Transmembrane Emp24 Protein Transport Domain Containing 9) is a Protein Coding gene. Among its related pathways are Alzheimers Disease Pathway. GO annotations related to this gene include syntaxin binding. An important paralog of this gene is TMED4.

UniProtKB/Swiss-Prot for TMED9 Gene

  • Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer-dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 isoform PTPB.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMED9 Gene

Genomics for TMED9 Gene

Regulatory Elements for TMED9 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMED9 Gene

Start:
177,592,158 bp from pter
End:
177,596,124 bp from pter
Size:
3,967 bases
Orientation:
Plus strand

Genomic View for TMED9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMED9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMED9 Gene

Proteins for TMED9 Gene

  • Protein details for TMED9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BVK6-TMED9_HUMAN
    Recommended name:
    Transmembrane emp24 domain-containing protein 9
    Protein Accession:
    Q9BVK6
    Secondary Accessions:
    • Q14437
    • Q8WZ61

    Protein attributes for TMED9 Gene

    Size:
    235 amino acids
    Molecular mass:
    27277 Da
    Quaternary structure:
    • Monomer and homodimer in endoplasmic reticulum. Predominantly monomeric and to lesser extent homodimeric in endoplasmic reticulum-Golgi intermediate compartment and cis-Golgi network. Probably oligomerizes with other members of the EMP24/GP25L family such as TMED2, TMED7 and TMED10. Interacts with TMED5. Interacts (via C-terminus) with COPG1; the interaction involves dimeric TMED9. Interacts with PTPN2 and SPAST. Interacts with STX17; the interaction is direct.
    SequenceCaution:
    • Sequence=AAL35268.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA62380.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for TMED9 Gene

Proteomics data for TMED9 Gene at MOPED

Post-translational modifications for TMED9 Gene

Other Protein References for TMED9 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for TMED9

No data available for DME Specific Peptides for TMED9 Gene

Domains for TMED9 Gene

Protein Domains for TMED9 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TMED9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BVK6

UniProtKB/Swiss-Prot:

TMED9_HUMAN :
  • Q9BVK6
Domain:
  • Contains 1 GOLD domain.
Family:
  • Belongs to the EMP24/GP25L family.
genes like me logo Genes that share domains with TMED9: view

No data available for Gene Families for TMED9 Gene

Function for TMED9 Gene

Molecular function for TMED9 Gene

UniProtKB/Swiss-Prot Function:
Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer-dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 isoform PTPB.

Gene Ontology (GO) - Molecular Function for TMED9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16595549
GO:0019905 syntaxin binding IPI 21545355
genes like me logo Genes that share ontologies with TMED9: view

Phenotypes for TMED9 Gene

GenomeRNAi human phenotypes for TMED9:
genes like me logo Genes that share phenotypes with TMED9: view

Animal Model Products

miRNA for TMED9 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMED9

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMED9 Gene

Localization for TMED9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMED9 Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Note=Cycles between compartments of the early secretatory pathway.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMED9 Gene COMPARTMENTS Subcellular localization image for TMED9 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
cytosol 1
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TMED9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IMP 18287528
GO:0005783 endoplasmic reticulum IDA 12237308
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IDA 12237308
GO:0005794 Golgi apparatus IDA 12237308
genes like me logo Genes that share ontologies with TMED9: view

Pathways for TMED9 Gene

SuperPathways for TMED9 Gene

Superpath Contained pathways
1 Alzheimers Disease Pathway
genes like me logo Genes that share pathways with TMED9: view

Pathways by source for TMED9 Gene

1 Qiagen pathway for TMED9 Gene

Interacting Proteins for TMED9 Gene

Gene Ontology (GO) - Biological Process for TMED9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0007030 Golgi organization IMP 18287528
GO:0010638 positive regulation of organelle organization IMP 18287528
GO:0032527 NOT protein exit from endoplasmic reticulum IMP 18287528
GO:0034498 NOT early endosome to Golgi transport IMP 18287528
genes like me logo Genes that share ontologies with TMED9: view

Transcripts for TMED9 Gene

Unigene Clusters for TMED9 Gene

Transmembrane emp24 protein transport domain containing 9:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMED9

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMED9 Gene

No ASD Table

Relevant External Links for TMED9 Gene

GeneLoc Exon Structure for
TMED9
ECgene alternative splicing isoforms for
TMED9

Expression for TMED9 Gene

mRNA expression in normal human tissues for TMED9 Gene

Protein differential expression in normal tissues for TMED9 Gene

This gene is overexpressed in Nasal epithelium (32.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMED9 Gene

SOURCE GeneReport for Unigene cluster for TMED9 Gene Hs.279929

genes like me logo Genes that share expressions with TMED9: view

Expression partners for TMED9 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMED9 Gene

Orthologs for TMED9 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TMED9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMED9 35
  • 89.79 (n)
  • 92.77 (a)
TMED9 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC481444 35
  • 91.35 (n)
  • 94.04 (a)
TMED9 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmed9 35
  • 87.52 (n)
  • 93.62 (a)
Tmed9 16
Tmed9 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMED9 35
  • 99.29 (n)
  • 99.15 (a)
TMED9 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmed9 35
  • 87.09 (n)
  • 92.77 (a)
oppossum
(Monodelphis domestica)
Mammalia TMED9 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMED9 36
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 51 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia TMED9 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmed9 35
  • 75.4 (n)
  • 88.1 (a)
zebrafish
(Danio rerio)
Actinopterygii sbcb294 35
tmed9 35
  • 78.99 (n)
  • 90.76 (a)
tmed9 36
  • 82 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta eca 36
  • 64 (a)
ManyToMany
p24-2 36
  • 51 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea T08D2.1 36
  • 55 (a)
ManyToMany
Y60A3A.9 36
  • 67 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERP1 36
  • 26 (a)
ManyToMany
ERP5 36
  • 29 (a)
ManyToMany
ERP6 36
  • 29 (a)
ManyToMany
ERP1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 66 (a)
OneToMany
Species with no ortholog for TMED9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMED9 Gene

ENSEMBL:
Gene Tree for TMED9 (if available)
TreeFam:
Gene Tree for TMED9 (if available)

Paralogs for TMED9 Gene

Paralogs for TMED9 Gene

Selected SIMAP similar genes for TMED9 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMED9: view

Variants for TMED9 Gene

Sequence variations from dbSNP and Humsavar for TMED9 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs6634 -- 177,596,097(-) TTTTT(A/T)ATTGG utr-variant-3-prime
rs9232 -- 177,595,721(-) CCCAA(C/G)AGCAG utr-variant-3-prime
rs1049880 -- 177,596,041(+) AGAGT(C/T)TTAGT utr-variant-3-prime
rs1994354 -- 177,593,965(-) AGCCT(A/G)GGCTG intron-variant
rs4380682 -- 177,595,651(+) ACCCA(A/G)GGGCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TMED9 Gene

Variant ID Type Subtype PubMed ID
nsv883181 CNV Loss 21882294
nsv883182 CNV Gain 21882294
nsv5149 CNV Insertion 18451855
nsv883183 CNV Loss 21882294

Relevant External Links for TMED9 Gene

HapMap Linkage Disequilibrium report
TMED9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMED9 Gene

Disorders for TMED9 Gene

No disorders were found for TMED9 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TMED9 Gene

Publications for TMED9 Gene

  1. Syntaxin 17 cycles between the ER and ERGIC and is required to maintain the architecture of ERGIC and Golgi. (PMID: 21545355) Muppirala M. … Swarup G. (Biol. Cell 2011) 3 4
  2. Oligomeric state and stoichiometry of p24 proteins in the early secretory pathway. (PMID: 12237308) Jenne N. … Wieland F.T. (J. Biol. Chem. 2002) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  4. Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PMID: 12754519) Zhang H. … Aebersold R. (Nat. Biotechnol. 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for TMED9 Gene

Sources for TMED9 Gene

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