Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMED9 Gene

protein-coding   GIFtS: 49
GCID: GC05P177019

Transmembrane Emp24 Protein Transport Domain Containing...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transmembrane Emp24 Protein Transport Domain Containing 91 2     p252 3
Glycoprotein 25L22 3     HSGP25L2G2
GMP252 3     Gp25L2 Protein2
P24 Family Protein Alpha-22 3     Transmembrane Emp24 Domain-Containing Protein 92
p24alpha22 3     GP25L23

External Ids:    HGNC: 248781   Entrez Gene: 547322   Ensembl: ENSG000001848407   UniProtKB: Q9BVK63   

Export aliases for TMED9 gene to outside databases

Previous GC identifers: GC05P176952 GC05P171938


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TMED9 Gene: 
TMED9 (transmembrane emp24 protein transport domain containing 9) is a protein-coding gene. Diseases associated with TMED9 include hereditary spastic paraplegia, and paraplegia. GO annotations related to this gene include protein binding. An important paralog of this gene is TMED4.

UniProtKB/Swiss-Prot: TMED9_HUMAN, Q9BVK6
Function: Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI
vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory
pathway. Increases coatomer-dependent activity of ARFGAP2. Thought to play a crucial role in the specific
retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2
and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the
ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 isoform PTPB




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_023133.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMED9 gene promoter:
         c-Fos   Max1   ER-alpha   AP-1   AML1a   Fra-1   FosB   E47   c-Jun   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMED9 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMED9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMED9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.3   Ensembl cytogenetic band:  5q35.3   HGNC cytogenetic band: 5q35.3

TMED9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMED9 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P177019:  view genomic region     (about GC identifiers)

Start:
177,019,159 bp from pter      End:
177,023,125 bp from pter
Size:
3,967 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TMED9_HUMAN, Q9BVK6 (See protein sequence)
Recommended Name: Transmembrane emp24 domain-containing protein 9 precursor  
Size: 235 amino acids; 27277 Da
Subunit: Monomer and homodimer in endoplasmic reticulum. Predominantly monomeric and to lesser extent homodimeric
in endoplasmic reticulum-Golgi intermediate compartment and cis-Golgi network. Probably oligomerizes with other
members of the EMP24/GP25L family such as TMED2, TMED7 and TMED10. Interacts with TMED5. Interacts (via
C-terminus) with COPG1; the interaction involves dimeric TMED9. Interacts with PTPN2 and SPAST. Interacts with
STX17; the interaction is direct
Subcellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus,
cis-Golgi network membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate
compartment membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane;
Single-pass type I membrane protein (By similarity). Note=Cycles between compartments of the early secretatory
pathway
Sequence caution: Sequence=AAL35268.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAA62380.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q14437 Q8WZ61

Explore the universe of human proteins at neXtProt for TMED9: NX_Q9BVK6

Explore proteomics data for TMED9 at MOPED 

Post-translational modifications:

  • UniProtKB: N-linked glycosylated containing high mannose
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BVK6

  • TMED9 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TMED9 Protein Expression
    REFSEQ proteins: NP_059980.2  
    ENSEMBL proteins: 
     ENSP00000330945  

    Human Recombinant Protein Products for TMED9: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TMED9
    OriGene Protein Over-expression Lysate for TMED9
    OriGene MassSpec for TMED9 
    OriGene Custom Protein Services for TMED9
    GenScript Custom Purified and Recombinant Proteins Services for TMED9
    Novus Biologicals TMED9 Protein
    Novus Biologicals TMED9 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TMED9 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA12237308
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005793endoplasmic reticulum-Golgi intermediate compartment IDA12237308
    GO:0005794Golgi apparatus IDA12237308
    GO:0016021integral to membrane IEA--

    TMED9 for ontologies           About GeneDecksing



    TMED9 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for TMED9
    OriGene Custom Antibody Services for TMED9
    GenScript Custom Superior Antibodies Services for TMED9
    Novus Biologicals TMED9 Antibodies
    Abcam antibodies for TMED9
    Cloud-Clone Corp. Antibodies for TMED9 
    ThermoFisher Antibodies for TMED9
    LSBio Antibodies in human, mouse, rat for TMED9 

    Assay Products for TMED9: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TMED9
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TMED9
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TMED9 
    Cloud-Clone Corp. CLIAs for TMED9


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR009038 GOLD

    Graphical View of Domain Structure for InterPro Entry Q9BVK6

    ProtoNet protein and cluster: Q9BVK6

    1 Blocks protein domain: IPB000348 emp24/gp25L/p24 family

    UniProtKB/Swiss-Prot: TMED9_HUMAN, Q9BVK6
    Similarity: Belongs to the EMP24/GP25L family
    Similarity: Contains 1 GOLD domain


    TMED9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TMED9_HUMAN, Q9BVK6
    Function: Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI
    vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory
    pathway. Increases coatomer-dependent activity of ARFGAP2. Thought to play a crucial role in the specific
    retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2
    and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the
    ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 isoform PTPB

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16595549
    GO:0019905syntaxin binding IPI--
         
    TMED9 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TMED9:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TMED9 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TMED9

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMED9 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMED9 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMED9
    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate TMED9 (see all 28):
    hsa-miR-411* hsa-miR-4291 hsa-miR-495 hsa-miR-125a-5p hsa-miR-379* hsa-miR-29a hsa-miR-29c hsa-miR-200a
    SwitchGear 3'UTR luciferase reporter plasmidTMED9 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TMED9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMED9

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TMED9
    Sirion Biotech Customized adenovirus for overexpression of TMED9

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TMED9 (see all 7)
    OriGene ORF clones in mouse, rat for TMED9
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TMED9 (NM_017510)
    Sino Biological Human cDNA Clone for TMED9
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMED9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMED9
    Sirion Biotech Customized lentivirus for stable overexpression of TMED9 
                         Customized lentivirus expression plasmids for stable overexpression of TMED9 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TMED9
    Search LifeMap BioReagents cell lines for TMED9
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMED9


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMED9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/29 Interacting proteins for TMED9 (Q9BVK61, 3 ENSP000003309454) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TMED10P497553, ENSP000003031454I2D: score=4 STRING: ENSP00000303145
    IKBKEQ141643, ENSP000003560874I2D: score=1 STRING: ENSP00000356087
    ACTBP607093I2D: score=1 
    ACTG1P632613I2D: score=1 
    ATP13A1Q9HD203I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0007030Golgi organization IMP18287528
    GO:0010638positive regulation of organelle organization IMP18287528
    GO:0032527NOT protein exit from endoplasmic reticulum IMP18287528
    GO:0034498NOT early endosome to Golgi transport IMP18287528

    TMED9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMED9

    Search CenterWatch for drugs/clinical trials and news about TMED9

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TMED9 gene: 
    NM_017510.4  

    Unigene Cluster for TMED9:

    Transmembrane emp24 protein transport domain containing 9
    Hs.279929  [show with all ESTs]
    Unigene Representative Sequence: BX640856
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000332598(uc003mhx.3) ENST00000505521 ENST00000507723 ENST00000513799
    ENST00000507578 ENST00000510499
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMED9
    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate TMED9 (see all 28):
    hsa-miR-411* hsa-miR-4291 hsa-miR-495 hsa-miR-125a-5p hsa-miR-379* hsa-miR-29a hsa-miR-29c hsa-miR-200a
    SwitchGear 3'UTR luciferase reporter plasmidTMED9 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TMED9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMED9
    Clone
    Products:
         
    OriGene clones in human, mouse for TMED9 (see all 7)
    OriGene ORF clones in mouse, rat for TMED9
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TMED9 (NM_017510)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMED9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMED9
    Sirion Biotech Customized lentivirus for stable overexpression of TMED9 
                         Customized lentivirus expression plasmids for stable overexpression of TMED9 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TMED9
    OriGene qSTAR qPCR primer pairs in human, mouse for TMED9
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMED9
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMED9
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMED9

    Additional mRNA sequence: 

    AF441399.2 AK298435.1 AK313292.1 AY523817.1 BC001123.2 BC115367.1 BX640856.1 X90872.1 

    16 DOTS entries:

    DT.99948337  DT.447638  DT.120811561  DT.92458366  DT.95082477  DT.100886190  DT.95185987  DT.100886196 
    DT.120811559  DT.120811575  DT.100886198  DT.120811564  DT.95082419  DT.95082473  DT.120811552  DT.92407387 

    24/748 AceView cDNA sequences (see all 748):

    BI006668 BG421951 CB126271 AI251902 CR593286 AA376528 BG324876 CB215365 
    AI469886 AI963902 BU930990 BQ214584 CB215401 BI054499 BI056126 BG822010 
    CR621926 CR602419 CB141429 CR599794 AW290981 BI051410 CR591581 BE045502 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMED9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTTTCCCAA
    TMED9 Expression
    About this image


    See TMED9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMED9

    SOURCE GeneReport for Unigene cluster: Hs.279929
        SABiosciences Custom PCR Arrays for TMED9
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TMED9
    OriGene qSTAR qPCR primer pairs in human, mouse for TMED9
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMED9
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMED9
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMED9
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMED9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TMED9 gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmed91 , 5 transmembrane emp24 protein transport domain containing more1, 5 87.52(n)1
    93.62(a)1
      13 (30.06 cM)5
    675111  NM_026211.31  NP_080487.21 
     555931355 
    lizard
    (Anolis carolinensis)
    Reptilia TMED96
    Uncharacterized protein
    86(a)
    1 ↔ 1
    2(146098106-146106086)
    African clawed frog
    (Xenopus laevis)
    Amphibia CB197914.22   -- 79.58(n)    CB197914.2 
    zebrafish
    (Danio rerio)
    Actinopterygii sbcb2942 sbcb294 80.17(n)   368330  CF348806.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta eca6
    p24-26
    p24-related-2
    66(a)
    53(a)
    many ↔ many
    many ↔ many
    3R(5510191-5511198)
    3R(5513119-5518516)
    worm
    (Caenorhabditis elegans)
    Secernentea Y60A3A.96
    T08D2.16
    Protein T08D2.1
    70(a)
    56(a)
    many ↔ many
    many ↔ many
    V(19946734-19949095)
    X(162529-163134)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ERP1(YAR002C-A)4 Protein that forms a heterotrimeric complex with Erp2p, more   --   1(154724-154065) 851264  NP_009402.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G032901 emp24/gp25L/p24 family/GOLD domain-containing protein 42.65(n)
    27.94(a)
      814858  NM_126380.4  NP_178428.3 


    ENSEMBL Gene Tree for TMED9 (if available)
    TreeFam Gene Tree for TMED9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TMED9 gene
    TMED42  
    5 SIMAP similar genes for TMED9 using alignment to 1 protein entry:     TMED9_HUMAN:
    TMED4    TMED10    RNP24    TMED2    TMED7

    TMED9 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/148 SNPs in TMED9 are shown (see all 148)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1140196921,2
    F--177017274(+) GAACTC/TCTGGG 1 -- us2k11Minor allele frequency- T:0.03NA 120
    rs1478832401,2
    C--177017297(+) TCCTGC/TTTCTG 1 -- us2k10--------
    rs1415763031,2
    --177017343(+) CATGCC/TCAGCC 1 -- us2k10--------
    rs1883097961,2
    --177017355(+) ATTTTC/TACTTT 1 -- us2k10--------
    rs1931941911,2
    --177017519(+) ATGACA/GTAGTA 1 -- us2k10--------
    rs1825145481,2
    --177017633(+) TGTCTA/GTTCAA 1 -- us2k10--------
    rs1870267551,2
    C--177017635(+) TCTATC/TCAAGC 1 -- us2k10--------
    rs1911132271,2
    --177017707(+) GCATAG/TTCTGG 1 -- us2k10--------
    rs1836618301,2
    --177017932(+) TTCTAC/TGAGTT 1 -- us2k10--------
    rs287574371,2
    C,F--177018102(+) GGTCTC/ACTTGT 1 -- us2k111Minor allele frequency- A:0.41NA WA CSA EA 374

    HapMap Linkage Disequilibrium report for TMED9 (177019159 - 177023125 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TMED9:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv5149CNV Insertion18451855
    nsv883181CNV Loss21882294
    nsv883183CNV Loss21882294
    nsv883182CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TMED9
    DNA2.0 Custom Variant and Variant Library Synthesis for TMED9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    4 diseases for TMED9:    About MalaCards
    hereditary spastic paraplegia    paraplegia    spasticity    obesity


    TMED9 for disorders           About GeneDecksing


    Export disorders for TMED9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMED9 gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with TMED9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The cargo receptors Surf4, endoplasmic reticulum-Golgi intermediate compartment (ERGIC)-53, and p25 are required to maintain the architecture of ERGIC and Golgi. (PubMed id 18287528)1, 2 Mitrovic S.... Hauri H.-P. (2008)
    2. Evidence for a role of transmembrane protein p25 in localization of protein tyrosine phosphatase TC48 to the ER. (PubMed id 16595549)1, 2 Gupta V. and Swarup G. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PubMed id 12754519)1, 2 Zhang H.... Aebersold R. (2003)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    6. Oligomeric state and stoichiometry of p24 proteins in the early secretory pathway. (PubMed id 12237308)1, 2 Jenne N.... Wieland F.T. (2002)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)
    9. SGTA recognizes a noncanonical ubiquitin-like domain i n the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degra dation. (PubMed id 23246001)1 Xu Y....Ye Y. (2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54732 HGNC: 24878 AceView: HSGP25L2G Ensembl:ENSG00000184840 euGenes: HUgn54732
    ECgene: TMED9 H-InvDB: TMED9

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMED9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TMED9 gene:
    Search GeneIP for patents involving TMED9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TMED9   OriGene RNAi products in human, mouse, rat for TMED9  
     OriGene qPCR primer pairs and template standards for TMED9   OriGene Protein Over-expression Lysate for TMED9  
     OriGene MassSpec something-or-other for TMED9   OriGene clones in human, mouse for TMED9  
     OriGene qSTAR qPCR primer pairs in human, mouse for TMED9   OriGene Purified Protein for TMED9  
     OriGene ORF clones in mouse, rat for TMED9   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TMED9   OriGene Custom Protein Services for TMED9  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMED9
     QIAGEN SeqTarget long-range PCR primers for resequencing TMED9
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMED9
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMED9
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMED9
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMED9
     GenScript Custom Purified and Recombinant Proteins Services for TMED9 GenScript cDNA clones with any tag delivered in your preferred vector for TMED9
     GenScript Custom Assay Services for TMED9 GenScript Custom Superior Antibodies Services for TMED9
     GenScript Custom overexpressing Cell Line Services for TMED9 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TMED9 promoter
     Search Chromatin IP Primers for TMED9
     RT2 qPCR Primer Assay in human, mouse, rat TMED9
     Search GNC Networks for TMED9
     SABiosciences Custom PCR Arrays for TMED9
     Search Tocris compounds for TMED9
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for TMED9
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TMED9 antibodies
     TMED9 proteins
     TMED9 lysates
     Antibodies for TMED9
     See all of Abcam's Antibodies, Kits and Proteins for TMED9
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for TMED9
     Antibodies for TMED9
     ELISAs for TMED9
     CLIAs for TMED9
     Search LifeMap BioReagents cell lines for TMED9
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMED9
     SwitchGear 3'UTR luciferase reporter plasmids for TMED9
     SwitchGear Promoter luciferase reporter plasmids for TMED9
     ThermoFisher Antibodies for TMED9
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMED9
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TMED9
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TMED9
    Customized:
     lentivirus for stable overexpression of TMED9
     lentivirus expression plasmids for stable overexpression of TMED9
     adenovirus for overexpression of TMED9
     LSBio Antibodies in human, mouse, rat for TMED9
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TMED9 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4