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TMED8 Gene

protein-coding   GIFtS: 45
GCID: GC14M077808

Transmembrane Emp24 Protein Transport Domain Containing...

(Previous names: family with sequence similarity 15, member B, transmembrane...)
(Previous symbol: FAM15B)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Emp24 Protein Transport Domain Containing 81 2
FAM15B1 2 3
Family With Sequence Similarity 15, Member B1 2
Transmembrane Emp24 Domain Containing 81 2
Protein TMED82

External Ids:    HGNC: 186331   Entrez Gene: 2835782   Ensembl: ENSG000001005807   UniProtKB: Q6PL243   

Export aliases for TMED8 gene to outside databases

Previous GC identifers: GC14M076872 GC14M057974


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMED8 Gene:
TMED8 (transmembrane emp24 protein transport domain containing 8) is a protein-coding gene. Diseases associated with TMED8 include lung cancer. An important paralog of this gene is ACBD3.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NT_026437.13  NC_018925.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for TMED8
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMED8 promoter sequence
   Search Chromatin IP Primers for TMED8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMED8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3   Ensembl cytogenetic band:  14q24.3   HGNC cytogenetic band: 14q24.3

TMED8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMED8 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M077808:  view genomic region     (about GC identifiers)

Start:
77,801,364 bp from pter      End:
77,843,452 bp from pter
Size:
42,089 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TMED8_HUMAN, Q6PL24 (See protein sequence)
Recommended Name: Protein TMED8  
Size: 325 amino acids; 35740 Da
Sequence caution: Sequence=AAF62560.1; Type=Erroneous gene model prediction;
Secondary accessions: B3KTI6 Q3MJB0 Q9P1V9

Explore the universe of human proteins at neXtProt for TMED8: NX_Q6PL24

Explore proteomics data for TMED8 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys304
  • Modification sites at PhosphoSitePlus

  • See TMED8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_998766.1  
    ENSEMBL proteins: 
     ENSP00000216468  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR009038 GOLD

    Graphical View of Domain Structure for InterPro Entry Q6PL24

    ProtoNet protein and cluster: Q6PL24

    UniProtKB/Swiss-Prot: TMED8_HUMAN, Q6PL24
    Similarity: Contains 1 GOLD domain


    TMED8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         2 GenomeRNAi human phenotypes for TMED8:
     Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMED8
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    TMED8 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMED8
    Interactions:

        Search GeneGlobe Interaction Network for TMED8

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for TMED8 (ENSP000002164684) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BLZF1ENSP000003275414STRING: ENSP00000327541
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport IEA--

    TMED8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMED8



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TMED8 gene: 
    NM_213601.1  

    Unigene Clusters for TMED8:

    Transmembrane emp24 protein transport domain containing 8
    Hs.26403  [show with all ESTs], Hs.200413  [show with all ESTs]
    Unigene Representative Sequences: AK025695, AK095650
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000216468(uc001xtn.1 uc001xto.1)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat TMED8

    Additional mRNA sequence: 

    AK095650.1 AY598329.1 BC101510.1 BX248262.1 

    4 DOTS entries:

    DT.95201941  DT.100746133  DT.100842038  DT.95264227 

    Selected AceView cDNA sequences (see all 150):

    AA300700 BQ014519 AY598329 BM461621 BM676510 BI857773 AK025695 BM713893 
    BM450861 BU623005 AW675077 CB054627 BI861210 AI290654 BM456333 BX248262 
    BI494185 AW008288 CD676751 AI588878 Z44610 AA312430 NM_213601 AW673907 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMED8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAAATGCTA
    TMED8 Expression
    About this image

    TMED8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMED8 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.26403 Hs.200413
        Custom PCR Arrays for TMED8
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMED8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TMED8 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmed81 , 5 transmembrane emp24 domain containing 81, 5 86.26(n)1
    86.15(a)1
      12 (41.36 cM)5
    3826201  NM_001033475.31  NP_001028647.11 
     871662425 
    chicken
    (Gallus gallus)
    Aves TMED81 transmembrane emp24 protein transport domain containing more 75.7(n)
    78.04(a)
      423375  NM_001031206.1  NP_001026377.1 
    lizard
    (Anolis carolinensis)
    Reptilia TMED86
    transmembrane emp24 protein transport domain conta...
    52(a)
    1 ↔ 1
    1(20732240-20747541)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL899424.22   -- 78.43(n)    AL899424.2 
    zebrafish
    (Danio rerio)
    Actinopterygii tmed86
    transmembrane emp24 protein transport domain conta...
    44(a)
    1 ↔ 1
    17(45304833-45318846) ENSDARG00000052390
    fruit fly
    (Drosophila melanogaster)
    Insecta CG142326
    --
    20(a)
    1 → many
    X(19596021-19598292)
    worm
    (Caenorhabditis elegans)
    Secernentea Y41E3.76
    Protein Y41E3.7, isoform a
    25(a)
    1 → many
    IV(15014042-15025517) WBGene00012765


    ENSEMBL Gene Tree for TMED8 (if available)
    TreeFam Gene Tree for TMED8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TMED8 gene
    ACBD32  

    TMED8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMED8 (see all 685)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1438087481,2
    --77807683(+) GTGCTG/TTTCCC 1 -- ds50010--------
    rs1157543051,2
    F--77807688(+) TTTCCC/TTCTTC 1 -- ds50011Minor allele frequency- T:0.01WA 118
    rs1877766051,2
    C--77807769(+) GGGCAC/GCAATC 1 -- ds50010--------
    rs1125141761,2
    C--77807810(+) TTTTT-/AAAAAA 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1481472171,2
    --77807818(+) AAAACA/TTCGCC 1 -- ds50010--------
    rs1494824891,2
    C--77807975(+) GGCCA-/ACCAGTC 1 -- ds50010--------
    rs796014081,2
    C--77807976(+) GCCAA-/CAGTCAG 1 -- ds50010--------
    rs1119852661,2
    C--77808189(+) AGCAGG/ATAGAT 2 /Y syn11Minor allele frequency- A:0.50CSA 2
    rs740633331,2
    C,F--77808252(+) CGCCGG/ATACAC 2 /Y syn15Minor allele frequency- A:0.02WA CSA NA 4674
    rs1924421721,2
    --77808426(+) AGAGCA/GGGGAG 1 -- int10--------

    HapMap Linkage Disequilibrium report for TMED8 (77801364 - 77843452 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TMED8:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2659963CNV Deletion23128226
    esv2678214CNV Deletion23128226
    nsv902107CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TMED8
    DNA2.0 Custom Variant and Variant Library Synthesis for TMED8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for TMED8:    About MalaCards
    lung cancer


    TMED8 for disorders           About GeneDecksing


    Export disorders for TMED8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMED8 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TMED8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer. (PubMed id 15334068)1, 2 Petroziello J.... Carter P. (Oncogene 2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (Nature 2003)
    5. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (Science 2009)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 283578 HGNC: 18633 AceView: LOC283578 Ensembl:ENSG00000100580 euGenes: HUgn283578
    ECgene: TMED8 H-InvDB: TMED8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TMED8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMED8 gene:
    Search GeneIP for patents involving TMED8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Custom PCR Arrays for TMED8 Search Chromatin IP Primers for TMED8
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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