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Aliases for TMED8 Gene

Aliases for TMED8 Gene

  • Transmembrane P24 Trafficking Protein Family Member 8 2 3
  • Transmembrane Emp24 Protein Transport Domain Containing 8 2 3
  • Family With Sequence Similarity 15, Member B 2 3
  • Transmembrane Emp24 Domain Containing 8 2 3
  • FAM15B 3 4

External Ids for TMED8 Gene

Previous HGNC Symbols for TMED8 Gene

  • FAM15B

Previous GeneCards Identifiers for TMED8 Gene

  • GC14M076872
  • GC14M077808
  • GC14M057974

Summaries for TMED8 Gene

GeneCards Summary for TMED8 Gene

TMED8 (Transmembrane P24 Trafficking Protein Family Member 8) is a Protein Coding gene. An important paralog of this gene is ACBD3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMED8 Gene

Genomics for TMED8 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMED8 Gene

77,335,021 bp from pter
77,377,109 bp from pter
42,089 bases
Minus strand

Genomic View for TMED8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for TMED8 Gene

No data available for Regulatory Elements for TMED8 Gene

Proteins for TMED8 Gene

  • Protein details for TMED8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein TMED8
    Protein Accession:
    Secondary Accessions:
    • B3KTI6
    • Q3MJB0
    • Q9P1V9

    Protein attributes for TMED8 Gene

    325 amino acids
    Molecular mass:
    35740 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF62560.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for TMED8 Gene

Proteomics data for TMED8 Gene at MOPED

Post-translational modifications for TMED8 Gene

  • Ubiquitination at Lys 304
  • Modification sites at PhosphoSitePlus

Other Protein References for TMED8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMED8 Gene

Domains & Families for TMED8 Gene

Gene Families for TMED8 Gene

Protein Domains for TMED8 Gene


Suggested Antigen Peptide Sequences for TMED8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 GOLD domain.
  • Contains 1 GOLD domain.
genes like me logo Genes that share domains with TMED8: view

Function for TMED8 Gene

Phenotypes for TMED8 Gene

GenomeRNAi human phenotypes for TMED8:
genes like me logo Genes that share phenotypes with TMED8: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMED8

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for TMED8 Gene

Localization for TMED8 Gene

Gene Ontology (GO) - Cellular Components for TMED8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMED8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for TMED8 Gene

Pathways & Interactions for TMED8 Gene

SuperPathways for TMED8 Gene

No Data Available

Interacting Proteins for TMED8 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
Selected Interacting proteins: ENSP00000216468 for TMED8 Gene via STRING

Gene Ontology (GO) - Biological Process for TMED8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with TMED8: view

No data available for Pathways by source and SIGNOR curated interactions for TMED8 Gene

Drugs & Compounds for TMED8 Gene

No Compound Related Data Available

Transcripts for TMED8 Gene

mRNA/cDNA for TMED8 Gene

Unigene Clusters for TMED8 Gene

Transmembrane emp24 protein transport domain containing 8:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMED8

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMED8 Gene

No ASD Table

Relevant External Links for TMED8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMED8 Gene

mRNA expression in normal human tissues for TMED8 Gene

Protein differential expression in normal tissues from HIPED for TMED8 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.3) and Plasma (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMED8 Gene

SOURCE GeneReport for Unigene cluster for TMED8 Gene Hs.26403

genes like me logo Genes that share expression patterns with TMED8: view

Protein tissue co-expression partners for TMED8 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMED8 Gene

Orthologs for TMED8 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMED8 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMED8 35
  • 87.59 (n)
  • 85.23 (a)
TMED8 36
  • 84 (a)
(Canis familiaris)
Mammalia TMED8 35
  • 91.75 (n)
  • 91.99 (a)
TMED8 36
  • 91 (a)
(Mus musculus)
Mammalia Tmed8 35
  • 86.26 (n)
  • 86.15 (a)
Tmed8 16
Tmed8 36
  • 83 (a)
(Pan troglodytes)
Mammalia TMED8 35
  • 99.38 (n)
  • 99.69 (a)
TMED8 36
  • 100 (a)
(Rattus norvegicus)
Mammalia LOC681943 35
  • 83.66 (n)
  • 85.86 (a)
(Monodelphis domestica)
Mammalia TMED8 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia TMED8 36
  • 69 (a)
(Gallus gallus)
Aves TMED8 35
  • 75.7 (n)
  • 78.04 (a)
TMED8 36
  • 78 (a)
(Anolis carolinensis)
Reptilia TMED8 36
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100145041 35
  • 63.3 (n)
  • 58.77 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6331 35
(Danio rerio)
Actinopterygii tmed8 36
  • 44 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14232 36
  • 20 (a)
(Caenorhabditis elegans)
Secernentea Y41E3.7 36
  • 25 (a)
Species with no ortholog for TMED8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMED8 Gene

Gene Tree for TMED8 (if available)
Gene Tree for TMED8 (if available)

Paralogs for TMED8 Gene

Paralogs for TMED8 Gene

genes like me logo Genes that share paralogs with TMED8: view

Variants for TMED8 Gene

Sequence variations from dbSNP and Humsavar for TMED8 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs6636 -- 77,335,311(-) CCTAT(C/G)ATGAG utr-variant-3-prime
rs6637 -- 77,335,088(-) TGTGC(A/G)TTCTT utr-variant-3-prime
rs962629 -- 77,346,893(+) aattg(A/G)gctaa intron-variant
rs1544707 -- 77,366,540(+) AAGAC(A/G)GCCAG intron-variant
rs1544708 -- 77,366,739(+) catca(C/T)catat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMED8 Gene

Variant ID Type Subtype PubMed ID
nsv902107 CNV Loss 21882294
esv2678214 CNV Deletion 23128226
esv2659963 CNV Deletion 23128226

Variation tolerance for TMED8 Gene

Residual Variation Intolerance Score: 33.87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.98; 97.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMED8 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMED8 Gene

Disorders for TMED8 Gene

Relevant External Links for TMED8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TMED8: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMED8 Gene

Publications for TMED8 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 67
  3. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PMID: 19608861) Choudhary C. … Mann M. (Science 2009) 67
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 67
  5. Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer. (PMID: 15334068) Petroziello J. … Carter P. (Oncogene 2004) 67

Products for TMED8 Gene

Sources for TMED8 Gene

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