TMED7-TICAM2 Gene
protein-coding GIFtS: 34
GCID: GC05M114914
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TMED7-TICAM2 readthrough
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Aliases
for TMED7-TICAM2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TMED7-TICAM2 Readthrough1 2 | | TIRAP3b4 | | TAG2 | | Protein TMED7-TICAM24 | | TMED7-TICAM2 Read-Through Transcript2 | | TIR Domain-Containing Adapter Molecule 24 | | TRAM Adaptor With GOLD Domain2 | | TIRAP3b Long Form4 | | TICAM24 | | |
Export aliases for TMED7-TICAM2 gene to outside databasesPrevious GC identifers: GC00U926151 GC05M110095 |
Summaries
for TMED7-TICAM2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TMED7-TICAM2:
This locus represents naturally occurring read-through transcription between the neighboring transmembrane emp24protein transport domain containing 7 (TMED7) and toll-like receptor adaptor molecule 2 (TICAM2) genes. Alternativesplicing results in multiple transcript variants, one of which encodes a fusion protein that shares sequence identitywith the products of each individual gene. This fusion product functions to negatively regulate the adaptorMyD88-independent toll-like receptor 4 pathway. (provided by RefSeq, Nov 2010)
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Genomic Views
for TMED7-TICAM2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for TMED7-TICAM2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMED7-TICAM2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMED7-TICAM2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Ensembl cytogenetic band: 5q22.3 HGNC cytogenetic band: 5q22.3TMED7-TICAM2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M114914: view genomic region
(about GC identifiers)
Start:
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114,914,339 bp from pter |
End:
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114,961,876 bp from pter |
Size:
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47,538 bases |
Orientation:
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minus strand |
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Proteins
for TMED7-TICAM2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/TrEMBL: Q6JUT2 (See
protein sequence)Recommended Name: HCG37564, isoform CRA_c Size: 404 amino acids; 46173 DaPost-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6JUT2
TMED7-TICAM2 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins (2 alternative transcripts):
NP_001157940.1 NP_001157941.1
ENSEMBL proteins: ENSP00000282382 ENSP00000333650
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
-- | -- | | GO:0016021 | integral to membrane |
-- | -- |
TMED7-TICAM2 for ontologies About GeneDecksing
TMED7-TICAM2 Antibody Products:
Assay Products for TMED7-TICAM2: |
Protein
Domains /
Families
for TMED7-TICAM2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMED7-TICAM2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6JUT2ProtoNet protein and cluster: Q6JUT2 1 Blocks protein family: IPB000348 emp24/gp25L/p24 family
UniProtKB/TrEMBL: Q6JUT2 Similarity: Contains 1 GOLD domainSimilarity: Contains 1 TIR domain |
Function
for TMED7-TICAM2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMED7-TICAM2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMED7-TICAM2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): TMED7-TICAM2 (NM_001164468) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMED7-TICAM2 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TMED7-TICAM2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMED7-TICAM2 |
|
Pathways & Interactions
for TMED7-TICAM2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Toll-like receptor signaling pathway | | | 2 | Interleukin-1 signaling | |
2  BioSystems Pathways for TMED7-TICAM2
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMED7-TICAM2
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
TMED7-TICAM2 for ontologies About GeneDecksing
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Drugs & Compounds
for TMED7-TICAM2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMED7-TICAM2
Search CenterWatch for drugs/clinical trials and news about TMED7-TICAM2
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Transcripts
for TMED7-TICAM2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMED7-TICAM2 gene (2 alternative transcripts): NM_001164468.2 NM_001164469.2 3 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000282382 ENST00000333314 ENST00000514548
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMED7-TICAM2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMED7-TICAM2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): TMED7-TICAM2 (NM_001164468) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMED7-TICAM2 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TMED7-TICAM2 |
GeneLoc Exon Structure
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Expression
for TMED7-TICAM2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMED7-TICAM2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
Genevestigator expression for TMED7-TICAM2
SABiosciences Custom PCR Arrays for TMED7-TICAM2
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TMED7-TICAM2 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMED7-TICAM2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMED7-TICAM2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMED7-TICAM2 |
Orthologs
for TMED7-TICAM2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for TMED7-TICAM2 gene from 5/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
E1BQH3_CHICK6 |
Uncharacterized protein |
59(a) |
1 → many |
Z(71110462-71115876) |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
69(a) |
1 → many |
GL343193.1(8321020-8326692) |
zebrafish
(Danio rerio) |
Actinopterygii |
tmed76 |
transmembrane emp24 protein transport domain conta... |
66(a) |
1 → many |
8(442391-447707) |
fruit fly
(Drosophila melanogaster) |
Insecta |
p24-16 |
p24-related-1 |
41(a) |
1 → many |
X(11745364-11746548) |
worm
(Caenorhabditis elegans) |
Secernentea |
F57B10.56 |
Protein F57B10.5 |
49(a) |
1 → many |
I(6562698-6563661) |
ENSEMBL Gene Tree for TMED7-TICAM2 (if available)
TreeFam Gene Tree for TMED7-TICAM2 (if available) |
Paralogs
for TMED7-TICAM2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TMED7-TICAM2 gene
- TMED52 TMED12 TICAM22 TMED22 TMED32 TMED72
TMED7-TICAM2 for paralogs About GeneDecksing
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Genomic Variants
for TMED7-TICAM2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMED7-TICAM2 (114914339 - 114961876 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for TMED7-TICAM2
3 CNVs: 93197 81015 93198 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMED7-TICAM2 |
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Disorders
/ Diseases
for TMED7-TICAM2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for TMED7-TICAM2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMED7-TICAM2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMED7-TICAM2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)1 Prakash T....Taylor T.D. (2010)
- TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway. (PubMed id 19412184)1 Palsson-McDermott E.M....O'Neill L.A. (2009)
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1 Otsuki T....Isogai T. (2005)
- TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling. (PubMed id 12721283)1 Bin L.H.... Shu H.B. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for TMED7-TICAM2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing TMED7-TICAM2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMED7-TICAM2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMED7-TICAM2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMED7-TICAM2 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for TMED7-TICAM2 gene:
Search GeneIP for patents involving TMED7-TICAM2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMED7-TICAM2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMED7-TICAM2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMED7-TICAM2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMED7-TICAM2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMED7-TICAM2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMED7-TICAM2 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMED7-TICAM2 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMED7-TICAM2 |
|  |  |  | | | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TMED7-TICAM2 |
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