This locus represents naturally occurring read-through transcription between the neighboring transmembrane emp24 protein transport domain containing 7 (TMED7) and toll-like receptor adaptor molecule 2 (TICAM2) genes. Alternative splicing results in multiple transcript variants, one of which encodes a fusion protein that shares sequence identity with the products of each individual gene. This fusion product functions to negatively regulate the adaptor MyD88-independent toll-like receptor 4 pathway. [provided by RefSeq, Nov 2010]
GeneCards Summary for TMED7-TICAM2 Gene
TMED7-TICAM2 (TMED7-TICAM2 Readthrough) is a Protein Coding gene. Among its related pathways are Toll-like receptor signaling pathway and Interleukin-1 signaling. An important paralog of this gene is TMED3.