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Aliases for TMED7-TICAM2 Gene

Aliases for TMED7-TICAM2 Gene

  • TMED7-TICAM2 Readthrough 2 3 5

External Ids for TMED7-TICAM2 Gene

Previous GeneCards Identifiers for TMED7-TICAM2 Gene

  • GC00U926151
  • GC05M114914
  • GC05M110095

Summaries for TMED7-TICAM2 Gene

Entrez Gene Summary for TMED7-TICAM2 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring transmembrane emp24 protein transport domain containing 7 (TMED7) and toll-like receptor adaptor molecule 2 (TICAM2) genes. Alternative splicing results in multiple transcript variants, one of which encodes a fusion protein that shares sequence identity with the products of each individual gene. This fusion product functions to negatively regulate the adaptor MyD88-independent toll-like receptor 4 pathway. [provided by RefSeq, Nov 2010]

GeneCards Summary for TMED7-TICAM2 Gene

TMED7-TICAM2 (TMED7-TICAM2 Readthrough) is a Protein Coding gene. Among its related pathways are IL-1 signaling pathway. An important paralog of this gene is TMED7.

Additional gene information for TMED7-TICAM2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMED7-TICAM2 Gene

Genomics for TMED7-TICAM2 Gene

GeneHancer (GH) Regulatory Elements for TMED7-TICAM2 Gene

Promoters and enhancers for TMED7-TICAM2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I115623 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 550.8 +1.0 1023 4.2 HDGF PKNOX1 SMAD1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B TMED7-TICAM2 TICAM2 LOC101927100 TMED7 COMMD10
GH05I115540 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 10.5 +83.0 83034 5.1 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 FEM1C SEMA6A-AS1 ENSG00000250015 ATG12 LOC101927100 TICAM2 PGGT1B TMED7-TICAM2 TMED7 CCT5P1
GH05I115556 Enhancer 0.9 Ensembl ENCODE 10.9 +67.2 67224 3.9 PKNOX1 FOXA2 ZBTB21 JUN MAX YY1 ZNF26 HNF4G NFE2 ZNF362 TICAM2 LOC101927100 TMED7 TMED7-TICAM2 SEMA6A-AS1 FEM1C GC05P115575
GH05I115549 Enhancer 0.7 ENCODE 11.3 +76.8 76840 0.2 ELF3 CTCF PKNOX1 SIN3A RAD21 ZNF664 ZNF143 IKZF2 RUNX3 SRF CCDC112 LOC101927100 TICAM2 TMED7-TICAM2 TMED7 AP3S1 ATG12 FEM1C GC05P115575
GH05I115574 Enhancer 0.6 ENCODE 11.6 +51.4 51410 0.1 CTCF ZNF654 ZNF362 NR2F1 ZNF384 REST ZNF2 RAD21 IKZF1 SMC3 GC05P115575 LOC101927100 FEM1C TICAM2 CCDC112 TMED7-TICAM2 TMED7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMED7-TICAM2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TMED7-TICAM2 Gene

Genomic Locations for TMED7-TICAM2 Gene
chr5:115,578,496-115,626,179
(GRCh38/hg38)
Size:
47,684 bases
Orientation:
Minus strand
chr5:114,914,339-114,961,876
(GRCh37/hg19)

Genomic View for TMED7-TICAM2 Gene

Genes around TMED7-TICAM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMED7-TICAM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMED7-TICAM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMED7-TICAM2 Gene

Proteins for TMED7-TICAM2 Gene

  • Protein details for TMED7-TICAM2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A0A6YYA0
    Recommended name:
    Protein TMED7-TICAM2
    Protein Accession:
    A0A0A6YYA0

    Protein attributes for TMED7-TICAM2 Gene

    Size:
    188 amino acids
    Molecular mass:
    21233 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMED7-TICAM2 Gene

Post-translational modifications for TMED7-TICAM2 Gene

No Post-translational modifications

Other Protein References for TMED7-TICAM2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMED7-TICAM2 Gene

Domains & Families for TMED7-TICAM2 Gene

Gene Families for TMED7-TICAM2 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for TMED7-TICAM2 Gene

Suggested Antigen Peptide Sequences for TMED7-TICAM2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMED7-TICAM2: view

No data available for UniProtKB/Swiss-Prot for TMED7-TICAM2 Gene

Function for TMED7-TICAM2 Gene

Phenotypes From GWAS Catalog for TMED7-TICAM2 Gene

Phenotypes for TMED7-TICAM2 Gene

genes like me logo Genes that share phenotypes with TMED7-TICAM2: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMED7-TICAM2 Gene

Localization for TMED7-TICAM2 Gene

Gene Ontology (GO) - Cellular Components for TMED7-TICAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMED7-TICAM2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for TMED7-TICAM2 Gene

Pathways & Interactions for TMED7-TICAM2 Gene

SuperPathways for TMED7-TICAM2 Gene

SuperPathway Contained pathways
1 IL-1 signaling pathway
genes like me logo Genes that share pathways with TMED7-TICAM2: view

Pathways by source for TMED7-TICAM2 Gene

1 BioSystems pathway for TMED7-TICAM2 Gene

Interacting Proteins for TMED7-TICAM2 Gene

Gene Ontology (GO) - Biological Process for TMED7-TICAM2 Gene

None

No data available for SIGNOR curated interactions for TMED7-TICAM2 Gene

Drugs & Compounds for TMED7-TICAM2 Gene

No Compound Related Data Available

Transcripts for TMED7-TICAM2 Gene

mRNA/cDNA for TMED7-TICAM2 Gene

(2) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMED7-TICAM2 Gene

No ASD Table

Relevant External Links for TMED7-TICAM2 Gene

GeneLoc Exon Structure for
TMED7-TICAM2
ECgene alternative splicing isoforms for
TMED7-TICAM2

Expression for TMED7-TICAM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMED7-TICAM2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from PaxDb, MaxQB, and MOPED for TMED7-TICAM2 Gene



genes like me logo Genes that share expression patterns with TMED7-TICAM2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMED7-TICAM2 Gene

Orthologs for TMED7-TICAM2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TMED7-TICAM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TICAM2 34
  • 93 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TMED7 34
  • 85 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 79 (a)
OneToMany
cow
(Bos Taurus)
Mammalia TICAM2 34
  • 77 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ticam2 34
  • 72 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 70 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 76 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 40 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii tmed7 34
  • 69 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta p24-1 34
  • 43 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F57B10.5 34
  • 49 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EMP24 34
  • 21 (a)
OneToMany
ERP4 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9127 34
  • 48 (a)
OneToMany
Species where no ortholog for TMED7-TICAM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TMED7-TICAM2 Gene

ENSEMBL:
Gene Tree for TMED7-TICAM2 (if available)
TreeFam:
Gene Tree for TMED7-TICAM2 (if available)

Paralogs for TMED7-TICAM2 Gene

Paralogs for TMED7-TICAM2 Gene

genes like me logo Genes that share paralogs with TMED7-TICAM2: view

Variants for TMED7-TICAM2 Gene

Sequence variations from dbSNP and Humsavar for TMED7-TICAM2 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000002066 -- 115,615,435(-) T/C intron_variant
rs1000189939 -- 115,597,986(-) T/C intron_variant
rs1000243020 -- 115,606,411(-) G/A intron_variant
rs1000272926 -- 115,619,220(-) T/C intron_variant
rs1000373144 -- 115,600,878(-) G/A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMED7-TICAM2 Gene

Variant ID Type Subtype PubMed ID
nsv830455 CNV gain 17160897

Variation tolerance for TMED7-TICAM2 Gene

Residual Variation Intolerance Score: 60.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.10; 38.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMED7-TICAM2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMED7-TICAM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMED7-TICAM2 Gene

Disorders for TMED7-TICAM2 Gene

Additional Disease Information for TMED7-TICAM2

No disorders were found for TMED7-TICAM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMED7-TICAM2 Gene

Publications for TMED7-TICAM2 Gene

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3 58
  2. TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway. (PMID: 19412184) Palsson-McDermott EM … O'Neill LA (Nature immunology 2009) 3 58
  3. Genome-wide association with diabetes-related traits in the Framingham Heart Study. (PMID: 17903298) Meigs JB … Dupuis J (BMC medical genetics 2007) 44 58
  4. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 58
  5. TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling. (PMID: 12721283) Bin LH … Shu HB (The Journal of biological chemistry 2003) 3 58

Products for TMED7-TICAM2 Gene

Sources for TMED7-TICAM2 Gene

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