Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMED7-TICAM2 Gene

Aliases for TMED7-TICAM2 Gene

  • TMED7-TICAM2 Readthrough 2 3 5

External Ids for TMED7-TICAM2 Gene

Previous GeneCards Identifiers for TMED7-TICAM2 Gene

  • GC00U926151
  • GC05M114914
  • GC05M110095

Summaries for TMED7-TICAM2 Gene

Entrez Gene Summary for TMED7-TICAM2 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring transmembrane emp24 protein transport domain containing 7 (TMED7) and toll-like receptor adaptor molecule 2 (TICAM2) genes. Alternative splicing results in multiple transcript variants, one of which encodes a fusion protein that shares sequence identity with the products of each individual gene. This fusion product functions to negatively regulate the adaptor MyD88-independent toll-like receptor 4 pathway. [provided by RefSeq, Nov 2010]

GeneCards Summary for TMED7-TICAM2 Gene

TMED7-TICAM2 (TMED7-TICAM2 Readthrough) is a Protein Coding gene. Among its related pathways are Interleukin-1 signaling. An important paralog of this gene is TICAM2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMED7-TICAM2 Gene

Genomics for TMED7-TICAM2 Gene

Regulatory Elements for TMED7-TICAM2 Gene

Enhancers for TMED7-TICAM2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F115574 0.9 Ensembl ENCODE 11.6 +51.4 51379 0.4 CTCF ZNF362 ZNF654 MTA2 JUNB MAFG ZNF384 REST ZNF2 RAD21 LOC101927100 FEM1C TICAM2 CCDC112 TMED7-TICAM2 TMED7 GC05P115575
GH05F115551 0.9 Ensembl ENCODE 11.2 +74.7 74706 0.9 KLF1 TAL1 JUN CEBPB EP300 JUND GLIS1 HMBOX1 RCOR1 CCDC112 TICAM2 LOC101927100 TMED7-TICAM2 TMED7 AP3S1 ATG12 FEM1C GC05P115575
GH05F115556 0.9 Ensembl ENCODE 10.9 +67.2 67224 3.9 ZNF362 PKNOX1 JUN ZEB2 NR3C1 YY1 JUND ATF3 ZNF26 NFE2 TICAM2 LOC101927100 TMED7 TMED7-TICAM2 SEMA6A-AS1 FEM1C GC05P115575
GH05F115549 0.7 ENCODE 11.2 +76.8 76841 0.2 ELF3 SRF CTCF PKNOX1 TRIM22 RAD21 ZNF664 IKZF1 TCF7 ZNF143 CCDC112 TICAM2 LOC101927100 TMED7-TICAM2 TMED7 AP3S1 ATG12 FEM1C GC05P115575
GH05F115575 0.6 ENCODE 11.6 +50.2 50170 1.6 JUN MAFG SREBF1 JUND ZNF316 EED IKZF1 MAFK CREM TICAM2 LOC101927100 FEM1C CCDC112 TMED7-TICAM2 TMED7 GC05P115575 GC05P115579
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMED7-TICAM2 on UCSC Golden Path with GeneCards custom track

Promoters for TMED7-TICAM2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001287994 879 3401 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for TMED7-TICAM2 Gene

Chromosome:
5
Start:
115,578,496 bp from pter
End:
115,626,179 bp from pter
Size:
47,684 bases
Orientation:
Minus strand

Genomic View for TMED7-TICAM2 Gene

Genes around TMED7-TICAM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMED7-TICAM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMED7-TICAM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMED7-TICAM2 Gene

Proteins for TMED7-TICAM2 Gene

  • Protein details for TMED7-TICAM2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A0A6YYA0
    Recommended name:
    Protein TMED7-TICAM2
    Protein Accession:
    A0A0A6YYA0

    Protein attributes for TMED7-TICAM2 Gene

    Size:
    188 amino acids
    Molecular mass:
    21233 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMED7-TICAM2 Gene

Post-translational modifications for TMED7-TICAM2 Gene

No Post-translational modifications

Other Protein References for TMED7-TICAM2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMED7-TICAM2 Gene

Domains & Families for TMED7-TICAM2 Gene

Protein Domains for TMED7-TICAM2 Gene

Suggested Antigen Peptide Sequences for TMED7-TICAM2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMED7-TICAM2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMED7-TICAM2 Gene

Function for TMED7-TICAM2 Gene

Phenotypes for TMED7-TICAM2 Gene

genes like me logo Genes that share phenotypes with TMED7-TICAM2: view

Animal Model Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMED7-TICAM2 Gene

Localization for TMED7-TICAM2 Gene

Gene Ontology (GO) - Cellular Components for TMED7-TICAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMED7-TICAM2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for TMED7-TICAM2 Gene

Pathways & Interactions for TMED7-TICAM2 Gene

SuperPathways for TMED7-TICAM2 Gene

SuperPathway Contained pathways
1 Interleukin-1 signaling
genes like me logo Genes that share pathways with TMED7-TICAM2: view

Pathways by source for TMED7-TICAM2 Gene

1 BioSystems pathway for TMED7-TICAM2 Gene

Interacting Proteins for TMED7-TICAM2 Gene

Gene Ontology (GO) - Biological Process for TMED7-TICAM2 Gene

None

No data available for SIGNOR curated interactions for TMED7-TICAM2 Gene

Transcripts for TMED7-TICAM2 Gene

mRNA/cDNA for TMED7-TICAM2 Gene

(2) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TMED7-TICAM2 Gene

No ASD Table

Relevant External Links for TMED7-TICAM2 Gene

GeneLoc Exon Structure for
TMED7-TICAM2
ECgene alternative splicing isoforms for
TMED7-TICAM2

Expression for TMED7-TICAM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMED7-TICAM2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from PaxDb, MaxQB, and MOPED for TMED7-TICAM2 Gene



genes like me logo Genes that share expression patterns with TMED7-TICAM2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TMED7-TICAM2 Gene

Orthologs for TMED7-TICAM2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TMED7-TICAM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TICAM2 35
  • 93 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TMED7 35
  • 85 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 79 (a)
OneToMany
cow
(Bos Taurus)
Mammalia TICAM2 35
  • 77 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ticam2 35
  • 72 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 70 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 76 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 40 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii tmed7 35
  • 69 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta p24-1 35
  • 43 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F57B10.5 35
  • 49 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EMP24 35
  • 21 (a)
OneToMany
ERP4 37
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9127 35
  • 48 (a)
OneToMany
Species where no ortholog for TMED7-TICAM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TMED7-TICAM2 Gene

ENSEMBL:
Gene Tree for TMED7-TICAM2 (if available)
TreeFam:
Gene Tree for TMED7-TICAM2 (if available)

Paralogs for TMED7-TICAM2 Gene

Paralogs for TMED7-TICAM2 Gene

genes like me logo Genes that share paralogs with TMED7-TICAM2: view

Variants for TMED7-TICAM2 Gene

Sequence variations from dbSNP and Humsavar for TMED7-TICAM2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10036006 -- 115,581,740(+) TTAAG(C/T)ATAAA intron-variant
rs10041531 -- 115,581,709(+) ACAGG(A/G)AAATA intron-variant
rs10043094 -- 115,583,762(+) ACTCC(A/C)TCAGT intron-variant
rs10059059 -- 115,584,419(+) tcatt(A/C)cctgt intron-variant
rs10064977 -- 115,583,546(+) ACTAG(C/T)GGCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMED7-TICAM2 Gene

Variant ID Type Subtype PubMed ID
nsv830455 CNV gain 17160897

Variation tolerance for TMED7-TICAM2 Gene

Residual Variation Intolerance Score: 60.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.10; 38.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMED7-TICAM2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMED7-TICAM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMED7-TICAM2 Gene

Disorders for TMED7-TICAM2 Gene

Relevant External Links for TMED7-TICAM2

Genetic Association Database (GAD)
TMED7-TICAM2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMED7-TICAM2

No disorders were found for TMED7-TICAM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMED7-TICAM2 Gene

Publications for TMED7-TICAM2 Gene

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3 64
  2. TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway. (PMID: 19412184) Palsson-McDermott E.M. … O'Neill L.A. (Nat. Immunol. 2009) 3 64
  3. Genome-wide association with diabetes-related traits in the Framingham Heart Study. (PMID: 17903298) Meigs J.B. … Dupuis J. (BMC Med. Genet. 2007) 46 64
  4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 64
  5. TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling. (PMID: 12721283) Bin L.-H. … Shu H.-B. (J. Biol. Chem. 2003) 3 64

Products for TMED7-TICAM2 Gene

Sources for TMED7-TICAM2 Gene

Content
Loading form....