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TMED7-TICAM2 Gene

protein-coding   GIFtS: 30
GCID: GC05M114914

TMED7-TICAM2 Readthrough

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disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TMED7-TICAM2 Readthrough1 2
TMED7-TICAM2 Read-Through Transcript2
TRAM Adaptor With GOLD Domain2

External Ids:    HGNC: 339451   Entrez Gene: 1003027362   Ensembl: ENSG000002512017   UniProtKB: G3V2Y24   

Export aliases for TMED7-TICAM2 gene to outside databases

Previous GC identifers: GC00U926151 GC05M110095


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TMED7-TICAM2 Gene:
This locus represents naturally occurring read-through transcription between the neighboring transmembrane emp24
protein transport domain containing 7 (TMED7) and toll-like receptor adaptor molecule 2 (TICAM2) genes.
Alternative splicing results in multiple transcript variants, one of which encodes a fusion protein that shares
sequence identity with the products of each individual gene. This fusion product functions to negatively regulate
the adaptor MyD88-independent toll-like receptor 4 pathway. (provided by RefSeq, Nov 2010)

GeneCards Summary for TMED7-TICAM2 Gene:
TMED7-TICAM2 (TMED7-TICAM2 readthrough) is a protein-coding gene. An important paralog of this gene is TMED5.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for TMED7-TICAM2
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TMED7-TICAM2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMED7-TICAM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Ensembl cytogenetic band:  5q22.3   HGNC cytogenetic band: 5q22.3

TMED7-TICAM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMED7-TICAM2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M114914:  view genomic region     (about GC identifiers)

Start:
114,914,339 bp from pter      End:
114,961,876 bp from pter
Size:
47,538 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/TrEMBL: G3V2Y2 (See protein sequence)
Recommended Name: Transmembrane emp24 domain-containing protein 7  
Size: 82 amino acids; 8894 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

Explore proteomics data for TMED7-TICAM2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TMED7-TICAM2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001157940.1  NP_001157941.1  

    ENSEMBL proteins: 
     ENSP00000282382   ENSP00000333650  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR015718 P24-related
     IPR009038 GOLD

    Graphical View of Domain Structure for InterPro Entry G3V2Y2

    ProtoNet protein and cluster: G3V2Y2

    UniProtKB/TrEMBL: G3V2Y2
    Similarity: Belongs to the EMP24/GP25L family
    Similarity: Contains 1 GOLD domain


    Find genes that share domains with TMED7-TICAM2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with TMED7-TICAM2           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TMED7-TICAM2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/TrEMBL
    G3V2Y2 : Membrane; Single-pass type I membrane protein (By similarity)

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with TMED7-TICAM2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TMED7-TICAM2 About    
    See pathways by source

    SuperPathContained pathways About
    1Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.94
    2Interleukin-1 signaling
    IL1-mediated signaling events0.45


    2 BioSystems Pathways for TMED7-TICAM2
        Toll-like receptor signaling pathway
    IL1-mediated signaling events


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    Interactions:

        Search GeneGlobe Interaction Network for TMED7-TICAM2

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0007165signal transduction ----

    Find genes that share ontologies with TMED7-TICAM2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMED7-TICAM2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TMED7-TICAM2 gene (2 alternative transcripts): 
    NM_001164468.3  NM_001164469.3  

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000282382 ENST00000333314 ENST00000514548
    miRNA
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    hsa-miR-4307 hsa-miR-1303 hsa-miR-186 hsa-miR-4310 hsa-miR-580 hsa-miR-384
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    Inhib. RNA
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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMED7-TICAM2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TMED7-TICAM2 Expression
    About this image

    TMED7-TICAM2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMED7-TICAM2 Protein Expression
        Custom PCR Arrays for TMED7-TICAM2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMED7-TICAM2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TMED7-TICAM2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    76(a)
    1 → many
    Z(72816763-72823417)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    40(a)
    1 → many
    GL343193.1(8301237-8313846)
    zebrafish
    (Danio rerio)
    Actinopterygii tmed76
    transmembrane emp24 protein transport domain conta...
    69(a)
    1 → many
    8(442391-447707) ENSDARG00000046022
    fruit fly
    (Drosophila melanogaster)
    Insecta p24-16
    p24-related-1
    43(a)
    1 → many
    X(11745364-11746548)
    worm
    (Caenorhabditis elegans)
    Secernentea F57B10.56
    Protein F57B10.5 (F57B10.5) mRNA, complete cds
    49(a)
    1 → many
    I(6562699-6563660) WBGene00019003
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ERP4(YOR016C)4 Protein with similarity to Emp24p and Erv25p, member more   --   15(361084-360461) 854181  NP_014659.1 
            Species with no ortholog for TMED7-TICAM2

    ENSEMBL Gene Tree for TMED7-TICAM2 (if available)
    TreeFam Gene Tree for TMED7-TICAM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TMED7-TICAM2 gene
    TMED52  TICAM22  TMED12  TMED22  TMED32  TMED72  

    Find genes that share paralogs with TMED7-TICAM2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMED7-TICAM2 (see all 156)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs100790001,2
    C,F,A,H--114940200(+) GATAAC/ACCTCT 2 -- int123Minor allele frequency- A:0.30NS EA NA WA 2662
    rs732545991,2
    C,F--114940242(+) ATCCCC/ACATAA 2 -- int12Minor allele frequency- A:0.05WA 120
    rs2569641,2
    C,F,A,H--114940293(+) ataagG/Cggaac 2 -- int123Minor allele frequency- C:0.37NS EA NA WA CSA 2350
    rs1431374131,2
    C--114940472(+) AACAAC/TGTGGA 2 -- int10--------
    rs598571591,2
    C,F--114940484(+) TGTGAC/GTACAT 2 -- int15Minor allele frequency- G:0.14NA EA 246
    rs1830735511,2
    --114940545(+) CAACCC/GGGTAA 2 -- int10--------
    rs1481016581,2
    --114940618(+) ATTCAC/TATTCA 2 -- int10--------
    rs1410167951,2
    --114940619(+) TTCACA/CTTCAA 2 -- int10--------
    rs1501914641,2
    --114940646(+) CTCTGC/TCTGCA 2 -- int10--------
    rs1873507001,2
    C--114940682(+) TGACAC/TTTCTG 2 -- int10--------

    HapMap Linkage Disequilibrium report for TMED7-TICAM2 (114914339 - 114961876 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TMED7-TICAM2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830455CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with TMED7-TICAM2           About GenesLikeMe

    Genetic Association Database (GAD): TMED7-TICAM2

    Export disorders for TMED7-TICAM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMED7-TICAM2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TMED7-TICAM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    2. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    3. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)1 Prakash T....Taylor T.D. (PLoS ONE 2010)
    4. TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway. (PubMed id 19412184)1 Palsson-McDermott E.M....O'Neill L.A. (Nat. Immunol. 2009)
    5. Genome-wide association with diabetes-related traits in the Framingham Heart Study. (PubMed id 17903298)4 Meigs J.B....Dupuis J. (BMC Med. Genet. 2007)
    6. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1 Otsuki T....Isogai T. (DNA Res. 2005)
    7. TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling. (PubMed id 12721283)1 Bin L.-H.... Shu H.-B. (J. Biol. Chem. 2003)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 100302736 HGNC: 33945 Ensembl:ENSG00000251201 euGenes: HUgn100302736 ECgene: TMED7-TICAM2
    H-InvDB: TMED7-TICAM2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TMED7-TICAM2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMED7-TICAM2 gene:
    Search GeneIP for patents involving TMED7-TICAM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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