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Aliases for TMED7-TICAM2 Gene

Aliases for TMED7-TICAM2 Gene

  • TMED7-TICAM2 Readthrough 2 3 5

External Ids for TMED7-TICAM2 Gene

Previous GeneCards Identifiers for TMED7-TICAM2 Gene

  • GC00U926151
  • GC05M114914
  • GC05M110095

Summaries for TMED7-TICAM2 Gene

Entrez Gene Summary for TMED7-TICAM2 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring transmembrane emp24 protein transport domain containing 7 (TMED7) and toll-like receptor adaptor molecule 2 (TICAM2) genes. Alternative splicing results in multiple transcript variants, one of which encodes a fusion protein that shares sequence identity with the products of each individual gene. This fusion product functions to negatively regulate the adaptor MyD88-independent toll-like receptor 4 pathway. [provided by RefSeq, Nov 2010]

GeneCards Summary for TMED7-TICAM2 Gene

TMED7-TICAM2 (TMED7-TICAM2 Readthrough) is a Protein Coding gene. Among its related pathways are IL-1 signaling pathway. An important paralog of this gene is TICAM2.

Additional gene information for TMED7-TICAM2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMED7-TICAM2 Gene

Genomics for TMED7-TICAM2 Gene

Regulatory Elements for TMED7-TICAM2 Gene

Enhancers for TMED7-TICAM2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H115556 1 Ensembl ENCODE 10.9 +67.2 67224 3.9 PKNOX1 FOXA2 ZBTB21 JUN MAX YY1 ZNF26 HNF4G NFE2 ZNF362 TICAM2 LOC101927100 TMED7 TMED7-TICAM2 SEMA6A-AS1 FEM1C GC05P115575
GH05H115551 0.7 ENCODE 11.3 +74.7 74706 0.9 KLF1 TAL1 JUN CEBPB EP300 FOSL1 CTBP1 JUND GLIS1 HMBOX1 CCDC112 LOC101927100 TICAM2 TMED7-TICAM2 TMED7 ATG12 AP3S1 FEM1C GC05P115575
GH05H115549 0.7 ENCODE 11.2 +76.8 76841 0.2 ELF3 SMARCA5 CTCF PKNOX1 TRIM22 ELF1 RAD21 ZNF664 IKZF1 NBN CCDC112 TICAM2 LOC101927100 TMED7-TICAM2 TMED7 AP3S1 ATG12 FEM1C GC05P115575
GH05H115574 0.6 ENCODE 11.6 +51.4 51411 0.1 CTCF ZNF654 ZNF362 NR2F1 ZNF384 REST ZNF2 RAD21 IKZF1 SMC3 LOC101927100 FEM1C TICAM2 CCDC112 TMED7-TICAM2 TMED7 GC05P115575
GH05H115575 0.6 ENCODE 11.6 +50.2 50170 1.6 CTCF JUND EED JUN IKZF1 RUNX3 CREM TICAM2 LOC101927100 FEM1C CCDC112 TMED7-TICAM2 TMED7 GC05P115575 GC05P115579
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMED7-TICAM2 on UCSC Golden Path with GeneCards custom track

Promoters for TMED7-TICAM2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for TMED7-TICAM2 Gene

Genomic Locations for TMED7-TICAM2 Gene
47,684 bases
Minus strand

Genomic View for TMED7-TICAM2 Gene

Genes around TMED7-TICAM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMED7-TICAM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMED7-TICAM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMED7-TICAM2 Gene

Proteins for TMED7-TICAM2 Gene

  • Protein details for TMED7-TICAM2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    Protein TMED7-TICAM2
    Protein Accession:

    Protein attributes for TMED7-TICAM2 Gene

    188 amino acids
    Molecular mass:
    21233 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMED7-TICAM2 Gene

Post-translational modifications for TMED7-TICAM2 Gene

No Post-translational modifications

Other Protein References for TMED7-TICAM2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMED7-TICAM2 Gene

Domains & Families for TMED7-TICAM2 Gene

Gene Families for TMED7-TICAM2 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for TMED7-TICAM2 Gene

Suggested Antigen Peptide Sequences for TMED7-TICAM2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMED7-TICAM2: view

No data available for UniProtKB/Swiss-Prot for TMED7-TICAM2 Gene

Function for TMED7-TICAM2 Gene

Phenotypes for TMED7-TICAM2 Gene

genes like me logo Genes that share phenotypes with TMED7-TICAM2: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMED7-TICAM2 Gene

Localization for TMED7-TICAM2 Gene

Gene Ontology (GO) - Cellular Components for TMED7-TICAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMED7-TICAM2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for TMED7-TICAM2 Gene

Pathways & Interactions for TMED7-TICAM2 Gene

SuperPathways for TMED7-TICAM2 Gene

SuperPathway Contained pathways
1 IL-1 signaling pathway
genes like me logo Genes that share pathways with TMED7-TICAM2: view

Pathways by source for TMED7-TICAM2 Gene

1 BioSystems pathway for TMED7-TICAM2 Gene

Interacting Proteins for TMED7-TICAM2 Gene

Gene Ontology (GO) - Biological Process for TMED7-TICAM2 Gene


No data available for SIGNOR curated interactions for TMED7-TICAM2 Gene

Drugs & Compounds for TMED7-TICAM2 Gene

No Compound Related Data Available

Transcripts for TMED7-TICAM2 Gene


(2) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMED7-TICAM2 Gene

No ASD Table

Relevant External Links for TMED7-TICAM2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMED7-TICAM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMED7-TICAM2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from PaxDb, MaxQB, and MOPED for TMED7-TICAM2 Gene

genes like me logo Genes that share expression patterns with TMED7-TICAM2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMED7-TICAM2 Gene

Orthologs for TMED7-TICAM2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TMED7-TICAM2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TICAM2 34
  • 93 (a)
(Canis familiaris)
Mammalia TMED7 34
  • 85 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 79 (a)
(Bos Taurus)
Mammalia TICAM2 34
  • 77 (a)
(Mus musculus)
Mammalia Ticam2 34
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 70 (a)
(Gallus gallus)
Aves -- 34
  • 76 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 40 (a)
(Danio rerio)
Actinopterygii tmed7 34
  • 69 (a)
fruit fly
(Drosophila melanogaster)
Insecta p24-1 34
  • 43 (a)
(Caenorhabditis elegans)
Secernentea F57B10.5 34
  • 49 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EMP24 34
  • 21 (a)
ERP4 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9127 34
  • 48 (a)
Species where no ortholog for TMED7-TICAM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TMED7-TICAM2 Gene

Gene Tree for TMED7-TICAM2 (if available)
Gene Tree for TMED7-TICAM2 (if available)

Paralogs for TMED7-TICAM2 Gene

Paralogs for TMED7-TICAM2 Gene

genes like me logo Genes that share paralogs with TMED7-TICAM2: view

Variants for TMED7-TICAM2 Gene

Sequence variations from dbSNP and Humsavar for TMED7-TICAM2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000002066 -- 115,615,435(+) TGTAA(C/T)GAGTA intron-variant, utr-variant-3-prime
rs1000189939 -- 115,597,986(+) ATATA(C/T)ATGTA intron-variant
rs1000243020 -- 115,606,411(+) TCTAA(A/G)ATGCC intron-variant
rs1000272926 -- 115,619,220(+) AAATA(C/T)CATTT intron-variant
rs1000373144 -- 115,600,878(+) TAGGG(A/G)GGATT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMED7-TICAM2 Gene

Variant ID Type Subtype PubMed ID
nsv830455 CNV gain 17160897

Variation tolerance for TMED7-TICAM2 Gene

Residual Variation Intolerance Score: 60.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.10; 38.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMED7-TICAM2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMED7-TICAM2 Gene

Disorders for TMED7-TICAM2 Gene

Relevant External Links for TMED7-TICAM2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMED7-TICAM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMED7-TICAM2 Gene

Publications for TMED7-TICAM2 Gene

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3 60
  2. TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway. (PMID: 19412184) Palsson-McDermott EM … O'Neill LA (Nature immunology 2009) 3 60
  3. Genome-wide association with diabetes-related traits in the Framingham Heart Study. (PMID: 17903298) Meigs JB … Dupuis J (BMC medical genetics 2007) 45 60
  4. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 60
  5. TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling. (PMID: 12721283) Bin LH … Shu HB (The Journal of biological chemistry 2003) 3 60

Products for TMED7-TICAM2 Gene

Sources for TMED7-TICAM2 Gene

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