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Aliases for TMED7 Gene

Aliases for TMED7 Gene

  • Transmembrane Emp24 Protein Transport Domain Containing 7 2 3
  • P24 Family Protein Gamma-3 3 4
  • P24gamma3 3 4
  • P27 3 4
  • Transmembrane Emp24 Domain-Containing Protein 7 3
  • CGI-109 3

External Ids for TMED7 Gene

Previous GeneCards Identifiers for TMED7 Gene

  • GC05M114978
  • GC05M110130

Summaries for TMED7 Gene

GeneCards Summary for TMED7 Gene

TMED7 (Transmembrane Emp24 Protein Transport Domain Containing 7) is a Protein Coding gene. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Toll Like Receptor 7/8 (TLR7/8) Cascade. An important paralog of this gene is TMED3.

UniProtKB/Swiss-Prot for TMED7 Gene

  • Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Appears to play a role in the biosynthesis of secreted cargo including processing and post-translational modifications

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMED7 Gene

Genomics for TMED7 Gene

Genomic Location for TMED7 Gene

Start:
115,613,208 bp from pter
End:
115,632,992 bp from pter
Size:
19,785 bases
Orientation:
Minus strand

Genomic View for TMED7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMED7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMED7 Gene

No data available for Regulatory Elements for TMED7 Gene

Proteins for TMED7 Gene

  • Protein details for TMED7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3B3-TMED7_HUMAN
    Recommended name:
    Transmembrane emp24 domain-containing protein 7
    Protein Accession:
    Q9Y3B3
    Secondary Accessions:
    • Q8NBU8
    • Q8WUU6
    • Q96K51

    Protein attributes for TMED7 Gene

    Size:
    224 amino acids
    Molecular mass:
    25172 Da
    Quaternary structure:
    • Predominantly monomeric and to lesser extent homodimeric in endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment and cis-Golgi network. Oligomerizes with other members of the EMP24/GP25L family such as TMED2, TMED9 and TMED10. Interacts (via C-terminus) with COPG1; the interaction involves dimeric TMED7.

    Alternative splice isoforms for TMED7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMED7 Gene

Proteomics data for TMED7 Gene at MOPED

Post-translational modifications for TMED7 Gene

  • N-linked glycosylated in complex form containing terminal sialic acid.
  • Glycosylation at Asn103
  • Modification sites at PhosphoSitePlus

Other Protein References for TMED7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMED7 Gene

Domains for TMED7 Gene

Protein Domains for TMED7 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TMED7 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y3B3

UniProtKB/Swiss-Prot:

TMED7_HUMAN :
  • Q9Y3B3
Domain:
  • Contains 1 GOLD domain.
Family:
  • Belongs to the EMP24/GP25L family.
genes like me logo Genes that share domains with TMED7: view

No data available for Gene Families for TMED7 Gene

Function for TMED7 Gene

Molecular function for TMED7 Gene

UniProtKB/Swiss-Prot Function: Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Appears to play a role in the biosynthesis of secreted cargo including processing and post-translational modifications

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMED7 Gene

Localization for TMED7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMED7 Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, COPI-coated vesicle membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Single-pass type I membrane protein. Note=Cycles between compartments of the early secretatory pathway.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMED7 Gene COMPARTMENTS Subcellular localization image for TMED7 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
mitochondrion 2
cytosol 1
endosome 1
extracellular 1
lysosome 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TMED7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 12237308
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IDA 10359607
GO:0005794 Golgi apparatus IDA 12237308
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMED7: view

Pathways for TMED7 Gene

genes like me logo Genes that share pathways with TMED7: view

Pathways by source for TMED7 Gene

Interacting Proteins for TMED7 Gene

Gene Ontology (GO) - Biological Process for TMED7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with TMED7: view

Transcripts for TMED7 Gene

mRNA/cDNA for TMED7 Gene

(366) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMED7 Gene

Transmembrane emp24 protein transport domain containing 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMED7 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c · 6d · 6e
SP1: -
SP2: - - -
SP3: - - - -
SP4: -
SP5: - -
SP6:

Relevant External Links for TMED7 Gene

GeneLoc Exon Structure for
TMED7
ECgene alternative splicing isoforms for
TMED7

Expression for TMED7 Gene

mRNA expression in normal human tissues for TMED7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMED7 Gene

SOURCE GeneReport for Unigene cluster for TMED7 Gene Hs.642817

genes like me logo Genes that share expressions with TMED7: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMED7 Gene

Orthologs for TMED7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TMED7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMED7 35
  • 99.85 (n)
  • 100 (a)
TMED7 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMED7 35
  • 93.01 (n)
  • 95.98 (a)
TMED7 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 28 (a)
ManyToMany
TMED7 35
  • 92.26 (n)
  • 95.98 (a)
mouse
(Mus musculus)
Mammalia Tmed7 35
  • 90.18 (n)
  • 95.98 (a)
Tmed7 16
Tmed7 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 70 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tmed7 35
  • 90.62 (n)
  • 95.98 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 88 (a)
OneToMany
TMED7 35
  • 85.51 (n)
  • 96.86 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 67 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.7980 35
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76316 35
tmed7 35
  • 80.63 (n)
  • 93.19 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9389 35
zebrafish
(Danio rerio)
Actinopterygii tmed7 35
  • 72.48 (n)
  • 87.18 (a)
tmed7 36
  • 81 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000949 35
  • 56.35 (n)
  • 56.35 (a)
fruit fly
(Drosophila melanogaster)
Insecta p24-1 35
  • 54.21 (n)
  • 48.42 (a)
p24-1 36
  • 45 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F57B10.5 35
  • 57.53 (n)
  • 59.14 (a)
F57B10.5 36
  • 55 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR026W 35
  • 42.39 (n)
  • 27.75 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EMP24 36
  • 23 (a)
OneToMany
ERP2 35
  • 43.42 (n)
  • 26.49 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D14641g 35
  • 40.85 (n)
  • 27.17 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03800 35
  • 45.97 (n)
  • 34.62 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC17A5.08 35
  • 43.66 (n)
  • 33.15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9127 36
  • 52 (a)
OneToMany
Species with no ortholog for TMED7:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMED7 Gene

ENSEMBL:
Gene Tree for TMED7 (if available)
TreeFam:
Gene Tree for TMED7 (if available)

Paralogs for TMED7 Gene

Paralogs for TMED7 Gene

Selected SIMAP similar genes for TMED7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TMED7: view

Variants for TMED7 Gene

Relevant External Links for TMED7 Gene

HapMap Linkage Disequilibrium report
TMED7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for TMED7 Gene

Disorders for TMED7 Gene

Relevant External Links for TMED7

Genetic Association Database (GAD)
TMED7
Human Genome Epidemiology (HuGE) Navigator
TMED7
genes like me logo Genes that share disorders with TMED7: view

No data available for UniProtKB/Swiss-Prot for TMED7 Gene

Publications for TMED7 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4
  2. Oligomeric state and stoichiometry of p24 proteins in the early secretory pathway. (PMID: 12237308) Jenne N. … Wieland F.T. (J. Biol. Chem. 2002) 3 4
  3. Localization and recycling of gp27 (hp24gamma3): complex formation with other p24 family members. (PMID: 10359607) Fullekrug J. … Nilsson T. (Mol. Biol. Cell 1999) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for TMED7 Gene

Sources for TMED7 Gene

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