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Aliases for TMED7 Gene

Aliases for TMED7 Gene

  • Transmembrane P24 Trafficking Protein 7 2 3 5
  • Transmembrane Emp24 Protein Transport Domain Containing 7 2 3
  • P24 Family Protein Gamma-3 3 4
  • P24gamma3 3 4
  • P27 3 4
  • CGI-109 3
  • P24g3 3

External Ids for TMED7 Gene

Previous GeneCards Identifiers for TMED7 Gene

  • GC05M114978
  • GC05M110130

Summaries for TMED7 Gene

GeneCards Summary for TMED7 Gene

TMED7 (Transmembrane P24 Trafficking Protein 7) is a Protein Coding gene. Among its related pathways are Golgi-to-ER retrograde transport and Transport to the Golgi and subsequent modification. An important paralog of this gene is TMED5.

UniProtKB/Swiss-Prot for TMED7 Gene

  • Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Appears to play a role in the biosynthesis of secreted cargo including processing and post-translational modifications.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMED7 Gene

Genomics for TMED7 Gene

Regulatory Elements for TMED7 Gene

Enhancers for TMED7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMED7 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMED7 Gene

115,613,208 bp from pter
115,632,992 bp from pter
19,785 bases
Minus strand

Genomic View for TMED7 Gene

Genes around TMED7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMED7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMED7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMED7 Gene

Proteins for TMED7 Gene

  • Protein details for TMED7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane emp24 domain-containing protein 7
    Protein Accession:
    Secondary Accessions:
    • Q8NBU8
    • Q8WUU6
    • Q96K51

    Protein attributes for TMED7 Gene

    224 amino acids
    Molecular mass:
    25172 Da
    Quaternary structure:
    • Predominantly monomeric and to lesser extent homodimeric in endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment and cis-Golgi network. Oligomerizes with other members of the EMP24/GP25L family such as TMED2, TMED9 and TMED10. Interacts (via C-terminus) with COPG1; the interaction involves dimeric TMED7.

    Alternative splice isoforms for TMED7 Gene


neXtProt entry for TMED7 Gene

Proteomics data for TMED7 Gene at MOPED

Post-translational modifications for TMED7 Gene

  • N-linked glycosylated in complex form containing terminal sialic acid.
  • Glycosylation at Asn 103
  • Modification sites at PhosphoSitePlus

Other Protein References for TMED7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMED7 Gene

Domains & Families for TMED7 Gene

Gene Families for TMED7 Gene

Protein Domains for TMED7 Gene

Suggested Antigen Peptide Sequences for TMED7 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 GOLD domain.
  • Belongs to the EMP24/GP25L family.
  • Contains 1 GOLD domain.
  • Belongs to the EMP24/GP25L family.
genes like me logo Genes that share domains with TMED7: view

Function for TMED7 Gene

Molecular function for TMED7 Gene

UniProtKB/Swiss-Prot Function:
Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Appears to play a role in the biosynthesis of secreted cargo including processing and post-translational modifications.
genes like me logo Genes that share phenotypes with TMED7: view

Animal Model Products

miRNA for TMED7 Gene

miRTarBase miRNAs that target TMED7

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMED7 Gene

Localization for TMED7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMED7 Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, COPI-coated vesicle membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Single-pass type I membrane protein. Note=Cycles between compartments of the early secretatory pathway.

Subcellular locations from

Jensen Localization Image for TMED7 Gene COMPARTMENTS Subcellular localization image for TMED7 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
golgi apparatus 5

Gene Ontology (GO) - Cellular Components for TMED7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 12237308
GO:0005789 endoplasmic reticulum membrane IEA,TAS --
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IDA 10359607
GO:0016021 integral component of membrane IEA --
GO:0030126 COPI vesicle coat TAS 10359607
genes like me logo Genes that share ontologies with TMED7: view

Pathways & Interactions for TMED7 Gene

genes like me logo Genes that share pathways with TMED7: view

Interacting Proteins for TMED7 Gene

Gene Ontology (GO) - Biological Process for TMED7 Gene


No data available for SIGNOR curated interactions for TMED7 Gene

Drugs & Compounds for TMED7 Gene

No Compound Related Data Available

Transcripts for TMED7 Gene

mRNA/cDNA for TMED7 Gene

Unigene Clusters for TMED7 Gene

Transmembrane emp24 protein transport domain containing 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMED7 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c · 6d · 6e
SP1: -
SP2: - - -
SP3: - - - -
SP4: -
SP5: - -

Relevant External Links for TMED7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMED7 Gene

mRNA expression in normal human tissues for TMED7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMED7 Gene

This gene is overexpressed in Nasal epithelium (16.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMED7 Gene

SOURCE GeneReport for Unigene cluster for TMED7 Gene Hs.642817

genes like me logo Genes that share expression patterns with TMED7: view

Protein tissue co-expression partners for TMED7 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMED7 Gene

Orthologs for TMED7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TMED7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMED7 35
  • 93.01 (n)
  • 95.98 (a)
TMED7 36
  • 96 (a)
(Canis familiaris)
Mammalia TMED7 35
  • 92.26 (n)
  • 95.98 (a)
-- 36
  • 28 (a)
(Mus musculus)
Mammalia Tmed7 35
  • 90.18 (n)
  • 95.98 (a)
Tmed7 16
Tmed7 36
  • 96 (a)
(Pan troglodytes)
Mammalia TMED7 35
  • 99.85 (n)
  • 100 (a)
TMED7 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Tmed7 35
  • 90.62 (n)
  • 95.98 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 70 (a)
(Gallus gallus)
Aves TMED7 35
  • 85.51 (n)
  • 96.86 (a)
-- 36
  • 88 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76316 35
tmed7 35
  • 80.63 (n)
  • 93.19 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.7980 35
(Danio rerio)
Actinopterygii tmed7 35
  • 72.48 (n)
  • 87.18 (a)
tmed7 36
  • 81 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9389 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000949 35
  • 56.35 (n)
  • 56.35 (a)
fruit fly
(Drosophila melanogaster)
Insecta p24-1 35
  • 54.21 (n)
  • 48.42 (a)
p24-1 36
  • 45 (a)
(Caenorhabditis elegans)
Secernentea F57B10.5 35
  • 57.53 (n)
  • 59.14 (a)
F57B10.5 36
  • 55 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR026W 35
  • 42.39 (n)
  • 27.75 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D14641g 35
  • 40.85 (n)
  • 27.17 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERP2 35
  • 43.42 (n)
  • 26.49 (a)
EMP24 36
  • 23 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03800 35
  • 45.97 (n)
  • 34.62 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC17A5.08 35
  • 43.66 (n)
  • 33.15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9127 36
  • 52 (a)
Species with no ortholog for TMED7:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMED7 Gene

Gene Tree for TMED7 (if available)
Gene Tree for TMED7 (if available)

Paralogs for TMED7 Gene

Paralogs for TMED7 Gene

(7) SIMAP similar genes for TMED7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TMED7: view

Variants for TMED7 Gene

Variation tolerance for TMED7 Gene

Residual Variation Intolerance Score: 41.3% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for TMED7 Gene

Disorders for TMED7 Gene

Relevant External Links for TMED7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMED7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMED7 Gene

Publications for TMED7 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. The COP II adaptor protein TMED7 is required to initiate and mediate the delivery of TLR4 to the plasma membrane. (PMID: 25074978) Liaunardy-Jopeace A. … Gay N.J. (Sci Signal 2014) 3
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3

Products for TMED7 Gene

Sources for TMED7 Gene