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TMED7 Gene

protein-coding   GIFtS: 50
GCID: GC05M114978

Transmembrane Emp24 Protein Transport Domain Containing...

  Search for TMED7
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Emp24 Protein Transport Domain Containing 71 2
P24 Family Protein Gamma-32 3
p24gamma32 3
p272 3
Transmembrane Emp24 Domain-Containing Protein 72

External Ids:    HGNC: 242531   Entrez Gene: 510142   Ensembl: ENSG000001349707   UniProtKB: Q9Y3B33   

Export aliases for TMED7 gene to outside databases

Previous GC identifer: GC05M110130


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMED7 Gene:
TMED7 (transmembrane emp24 protein transport domain containing 7) is a protein-coding gene. An important paralog of this gene is TMED5.

UniProtKB/Swiss-Prot: TMED7_HUMAN, Q9Y3B3
Function: Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Appears to play
a role in the biosynthesis of secreted cargo including processing and post-translational modifications




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_034772.7  
Regulatory elements:
   Search for regulatory transcription factor binding sites for TMED7
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TMED7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMED7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q22.3   Ensembl cytogenetic band:  5q22.3   HGNC cytogenetic band: 5q22.3

TMED7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMED7 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M114978:  view genomic region     (about GC identifiers)

Start:
114,948,905 bp from pter      End:
114,968,689 bp from pter
Size:
19,785 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TMED7_HUMAN, Q9Y3B3 (See protein sequence)
Recommended Name: Transmembrane emp24 domain-containing protein 7 precursor  
Size: 224 amino acids; 25172 Da
Subunit: Predominantly monomeric and to lesser extent homodimeric in endoplasmic reticulum, endoplasmic
reticulum-Golgi intermediate compartment and cis-Golgi network. Oligomerizes with other members of the
EMP24/GP25L family such as TMED2, TMED9 and TMED10. Interacts (via C-terminus) with COPG1; the interaction
involves dimeric TMED7
Secondary accessions: Q8NBU8 Q8WUU6 Q96K51
Alternative splicing: 2 isoforms:  Q9Y3B3-1   Q9Y3B3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TMED7: NX_Q9Y3B3

Explore proteomics data for TMED7 at MOPED

Post-translational modifications: 

  • N-linked glycosylated in complex form containing terminal sialic acid1
  • Glycosylation2 at Asn103
  • Modification sites at PhosphoSitePlus

  • See TMED7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_861974.1  
    ENSEMBL proteins: 
     ENSP00000405926   ENSP00000450928  

    TMED7 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR015718 P24-related
     IPR009038 GOLD

    Graphical View of Domain Structure for InterPro Entry Q9Y3B3

    ProtoNet protein and cluster: Q9Y3B3

    1 Blocks protein domain: IPB000348 emp24/gp25L/p24 family

    UniProtKB/Swiss-Prot: TMED7_HUMAN, Q9Y3B3
    Similarity: Belongs to the EMP24/GP25L family
    Similarity: Contains 1 GOLD domain


    Find genes that share domains with TMED7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TMED7_HUMAN, Q9Y3B3
    Function: Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Appears to play
    a role in the biosynthesis of secreted cargo including processing and post-translational modifications

    Animal Models:

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    miRNA
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    miRTarBase miRNAs that target TMED7:
    hsa-let-7a-5p (MIRT032505), hsa-mir-222-3p (MIRT002334), hsa-mir-16-5p (MIRT051228), hsa-mir-148a-3p (MIRT007017), hsa-mir-221-3p (MIRT002335), hsa-mir-24-3p (MIRT030550), hsa-mir-451a (MIRT006597), hsa-mir-30a-5p (MIRT005186), hsa-mir-181b-5p (MIRT006232)

    Block miRNA regulation of human, mouse, rat TMED7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TMED7 (see all 57):
    hsa-miR-548j hsa-miR-300 hsa-miR-570 hsa-miR-183* hsa-miR-548d-5p hsa-miR-548a-5p hsa-miR-23a hsa-miR-192*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TMED7_HUMAN, Q9Y3B3: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus,
    cis-Golgi network membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate
    compartment membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, COPI-coated vesicle membrane;
    Single-pass type I membrane protein (By similarity). Cytoplasmic vesicle, COPII-coated vesicle membrane;
    Single-pass type I membrane protein (By similarity). Note=Cycles between compartments of the early secretatory
    pathway
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    golgi apparatus5
    mitochondrion2
    cytosol1
    endosome1
    extracellular1
    lysosome1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA12237308
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005793endoplasmic reticulum-Golgi intermediate compartment IDA10359607
    GO:0005794Golgi apparatus IDA12237308
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TMED7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TMED7 About    
    See pathways by source

    SuperPathContained pathways About
    1Toll Like Receptor 7/8 (TLR7/8) Cascade
    MyD88-independent cascade0.69
    TRIF-mediated programmed cell death0.00
    Toll Like Receptor 3 (TLR3) Cascade0.69




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMED7
    Interactions:

        Search GeneGlobe Interaction Network for TMED7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TMED7 (Q9Y3B33 ENSP000004059264) via UniProtKB, MINT, STRING, and/or I2D (see all 82)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL1R1P147783I2D: score=1 
    IL1RAPQ9NPH33I2D: score=1 
    IRAK2O431873I2D: score=1 
    IRAK3Q9Y6163I2D: score=1 
    IRF3Q146533I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0015031protein transport IEA--

    Find genes that share ontologies with TMED7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMED7



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TMED7 gene: 
    NM_181836.5  

    Unigene Cluster for TMED7:

    Transmembrane emp24 protein transport domain containing 7
    Hs.642817  [show with all ESTs]
    Unigene Representative Sequence: BM805167
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000456936(uc011cwd.2 uc003krf.3) ENST00000503010 ENST00000508420

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TMED7 (see all 57):
    hsa-miR-548j hsa-miR-300 hsa-miR-570 hsa-miR-183* hsa-miR-548d-5p hsa-miR-548a-5p hsa-miR-23a hsa-miR-192*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TMED7 (NM_181836)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMED7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMED7
    Primer
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    OriGene qPCR primer pairs and template standards for TMED7
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      QuantiTect SYBR Green Assays in human, mouse, rat TMED7
      QuantiFast Probe-based Assays in human, mouse, rat TMED7

    Additional mRNA sequence: 

    AB002450.1 AB002451.1 

    8 DOTS entries:

    DT.91706620  DT.317427  DT.91756295  DT.120852782  DT.95134717  DT.120852775  DT.120852795  DT.95134675 

    Selected AceView cDNA sequences (see all 366):

    AW514768 BM979831 BM824561 AW450623 AI423680 AI625549 AI304459 AA287681 
    AA427692 CA441688 AB109098 AW510525 BE062250 AA318722 W32427 CA867704 
    AA382927 AI276165 AI917913 BU684585 CA440665 BE502913 CN479117 AA460222 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TMED7 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c · 6d · 6e
    SP1:                                      -                                                         
    SP2:                                      -                 -     -                                 
    SP3:                                      -                 -     -     -                           
    SP4:                                      -                                                         
    SP5:                                                        -     -                                 


    ECgene alternative splicing isoforms for TMED7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMED7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTAAAATTGA
    TMED7 Expression
    About this image


    TMED7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Paraxial Mesoderm Cells Branchial Arch 1
     
     Head Mesenchyme (Muscoskeletal System)
             Paraxial Mesoderm Cells Branchial Arch 1
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    TMED7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMED7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.642817
        Custom PCR Arrays for TMED7
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMED7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TMED7 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmed71 , 5 transmembrane emp24 protein transport domain containing more1, 5 90.18(n)1
    95.98(a)1
      18 (24.65 cM)5
    666761  NM_025698.11  NP_079974.11 
     465602355 
    chicken
    (Gallus gallus)
    Aves TMED71 transmembrane emp24 protein transport domain containing more 85.51(n)
    96.86(a)
      769360  XM_003643074.2  XP_003643122.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    67(a)
    many ↔ many
    GL343193.1(8316331-8326984)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.79802 Xenopus laevis transcribed sequence with moderate similarity more 78.65(n)    CD327203.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tmed71 transmembrane emp24 protein transport domain containing more 72.48(n)
    87.18(a)
      405848  NM_212912.1  NP_998077.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta p24-11 p24-related-1 54.21(n)
    48.42(a)
      32140  NM_001272536.1  NP_001259465.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F57B10.51 F57B10.5 57.53(n)
    59.14(a)
      172372  NM_059491.4  NP_491892.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ERP21 ERP2 43.42(n)
    26.49(a)
      851226   NP_009395.1 


    ENSEMBL Gene Tree for TMED7 (if available)
    TreeFam Gene Tree for TMED7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TMED7 gene
    TMED52  TICAM22  TMED12  TMED7-TICAM22  TMED22  TMED32  
    7 SIMAP similar genes for TMED7 using alignment to 3 protein entries:     TMED7_HUMAN (see all proteins):
    TMED3    RNP24    TMED2    TMED4    TMED5    TMED9
    TMED1

    Find genes that share paralogs with TMED7           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TMED7
    DNA2.0 Custom Variant and Variant Library Synthesis for TMED7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with TMED7           About GenesLikeMe

    Genetic Association Database (GAD): TMED7
    Human Genome Epidemiology (HuGE) Navigator: TMED7 (1 document)

    Export disorders for TMED7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for TMED7 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with TMED7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.-H.... Lin W.-C. (Genome Res. 2000)
    2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Oligomeric state and stoichiometry of p24 proteins in the early secretory pathway. (PubMed id 12237308)1, 2 Jenne N.... Wieland F.T. (J. Biol. Chem. 2002)
    6. Localization and recycling of gp27 (hp24gamma3): complex formation with other p24 family members. (PubMed id 10359607)1, 2 Fullekrug J.... Nilsson T. (Mol. Biol. Cell 1999)
    7. The GOLD domain-containing protein TMED7 inhibits TLR4 signalling from the endosome upon LPS stimulation. (PubMed id 22426228)1 Doyle S.L....McGettrick A.F. (Nat Commun 2012)
    8. Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph. (PubMed id 21048031)1 Casabonne D....de Sanjose S. (Haematologica 2011)
    9. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51014 HGNC: 24253 AceView: TICAM2andCGI-109 Ensembl:ENSG00000134970 euGenes: HUgn51014
    ECgene: TMED7 H-InvDB: TMED7

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TMED7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMED7 gene:
    Search GeneIP for patents involving TMED7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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