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Aliases for TMED7 Gene

Aliases for TMED7 Gene

  • Transmembrane P24 Trafficking Protein 7 2 3 5
  • Transmembrane Emp24 Protein Transport Domain Containing 7 2 3
  • P24 Family Protein Gamma-3 3 4
  • P24gamma3 3 4
  • P27 3 4
  • Transmembrane Emp24 Domain-Containing Protein 7 3
  • CGI-109 3
  • P24g3 3

External Ids for TMED7 Gene

Previous GeneCards Identifiers for TMED7 Gene

  • GC05M114978
  • GC05M110130

Summaries for TMED7 Gene

GeneCards Summary for TMED7 Gene

TMED7 (Transmembrane P24 Trafficking Protein 7) is a Protein Coding gene. Among its related pathways are TRAF Pathway and Vesicle-mediated transport. An important paralog of this gene is TMED7-TICAM2.

UniProtKB/Swiss-Prot for TMED7 Gene

  • Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Appears to play a role in the biosynthesis of secreted cargo including processing and post-translational modifications.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMED7 Gene

Genomics for TMED7 Gene

Regulatory Elements for TMED7 Gene

Enhancers for TMED7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G115556 1 Ensembl ENCODE 16.3 +74.0 74037 3.9 PKNOX1 FOXA2 ZBTB21 JUN MAX YY1 GATA2 ZNF26 HNF4G NFE2 TICAM2 LOC101927100 TMED7 TMED7-TICAM2 SEMA6A-AS1 FEM1C GC05P115575
GH05G116076 1.2 FANTOM5 Ensembl ENCODE 10.5 -443.7 -443727 0.6 SRF MTA2 BACH1 JUNB DPF2 TBX21 ARID3A EGR1 EED IKZF1 LVRN ATG12 AP3S1 TMED7 COMMD10 ENSG00000272265 ENSG00000271918 RPS25P6
GH05G115549 0.7 ENCODE 11.1 +83.7 83654 0.2 ELF3 SRF CTCF PKNOX1 TRIM22 GATAD2B RAD21 ZNF664 IKZF1 ZNF143 CCDC112 TICAM2 LOC101927100 TMED7-TICAM2 TMED7 AP3S1 ATG12 FEM1C GC05P115575
GH05G115574 0.7 ENCODE 10.9 +58.2 58224 0.1 CTCF ZNF654 ZNF362 BHLHE40 NR2F1 ZNF384 REST ZNF2 RAD21 CBX5 LOC101927100 FEM1C TICAM2 CCDC112 TMED7-TICAM2 TMED7 GC05P115575
GH05G115575 0.7 ENCODE 10.9 +57.0 56983 1.6 CTCF JUN MAFG SREBF1 JUND ZNF316 GATA2 EED IKZF1 FOS TICAM2 LOC101927100 FEM1C CCDC112 TMED7-TICAM2 TMED7 GC05P115575 GC05P115579
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMED7 on UCSC Golden Path with GeneCards custom track

Promoters for TMED7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for TMED7 Gene

115,613,208 bp from pter
115,632,992 bp from pter
19,785 bases
Minus strand

Genomic View for TMED7 Gene

Genes around TMED7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMED7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMED7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMED7 Gene

Proteins for TMED7 Gene

  • Protein details for TMED7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane emp24 domain-containing protein 7
    Protein Accession:
    Secondary Accessions:
    • Q8NBU8
    • Q8WUU6
    • Q96K51

    Protein attributes for TMED7 Gene

    224 amino acids
    Molecular mass:
    25172 Da
    Quaternary structure:
    • Predominantly monomeric and to lesser extent homodimeric in endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment and cis-Golgi network. Oligomerizes with other members of the EMP24/GP25L family such as TMED2, TMED9 and TMED10. Interacts (via C-terminus) with COPG1; the interaction involves dimeric TMED7.

    Alternative splice isoforms for TMED7 Gene


neXtProt entry for TMED7 Gene

Post-translational modifications for TMED7 Gene

  • N-linked glycosylated in complex form containing terminal sialic acid.
  • Glycosylation at isoforms=2103
  • Modification sites at PhosphoSitePlus

Other Protein References for TMED7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMED7 Gene

Domains & Families for TMED7 Gene

Gene Families for TMED7 Gene

Protein Domains for TMED7 Gene

Suggested Antigen Peptide Sequences for TMED7 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the EMP24/GP25L family.
  • Belongs to the EMP24/GP25L family.
genes like me logo Genes that share domains with TMED7: view

Function for TMED7 Gene

Molecular function for TMED7 Gene

UniProtKB/Swiss-Prot Function:
Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Appears to play a role in the biosynthesis of secreted cargo including processing and post-translational modifications.
genes like me logo Genes that share phenotypes with TMED7: view

Animal Model Products

CRISPR Products

miRNA for TMED7 Gene

miRTarBase miRNAs that target TMED7

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMED7 Gene

Localization for TMED7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMED7 Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, COPI-coated vesicle membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Single-pass type I membrane protein. Note=Cycles between compartments of the early secretatory pathway.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMED7 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
golgi apparatus 5

Gene Ontology (GO) - Cellular Components for TMED7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005783 endoplasmic reticulum IEA,IDA 12237308
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IDA 10359607
GO:0005794 Golgi apparatus IDA,IEA 12237308
genes like me logo Genes that share ontologies with TMED7: view

Pathways & Interactions for TMED7 Gene

genes like me logo Genes that share pathways with TMED7: view

Gene Ontology (GO) - Biological Process for TMED7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with TMED7: view

No data available for SIGNOR curated interactions for TMED7 Gene

Drugs & Compounds for TMED7 Gene

No Compound Related Data Available

Transcripts for TMED7 Gene

mRNA/cDNA for TMED7 Gene

Unigene Clusters for TMED7 Gene

Transmembrane emp24 protein transport domain containing 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMED7 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c · 6d · 6e
SP1: -
SP2: - - -
SP3: - - - -
SP4: -
SP5: - -

Relevant External Links for TMED7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMED7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMED7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMED7 Gene

This gene is overexpressed in Nasal epithelium (16.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMED7 Gene

Protein tissue co-expression partners for TMED7 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMED7 Gene:


SOURCE GeneReport for Unigene cluster for TMED7 Gene:

genes like me logo Genes that share expression patterns with TMED7: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMED7 Gene

Orthologs for TMED7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TMED7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMED7 34 35
  • 99.85 (n)
(Bos Taurus)
Mammalia TMED7 34 35
  • 93.01 (n)
(Canis familiaris)
Mammalia TMED7 34
  • 92.26 (n)
-- 35
  • 28 (a)
(Rattus norvegicus)
Mammalia Tmed7 34
  • 90.62 (n)
(Mus musculus)
Mammalia Tmed7 34 16 35
  • 90.18 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 70 (a)
(Gallus gallus)
Aves -- 35
  • 88 (a)
TMED7 34
  • 85.51 (n)
(Anolis carolinensis)
Reptilia -- 35
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmed7 34
  • 80.63 (n)
MGC76316 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.7980 34
(Danio rerio)
Actinopterygii tmed7 34 35
  • 72.48 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9389 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000949 34
  • 56.35 (n)
fruit fly
(Drosophila melanogaster)
Insecta p24-1 34 35
  • 54.21 (n)
(Caenorhabditis elegans)
Secernentea F57B10.5 34 35
  • 57.53 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERP2 34
  • 43.42 (n)
EMP24 35
  • 23 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR026W 34
  • 42.39 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D14641g 34
  • 40.85 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9127 35
  • 52 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03800 34
  • 45.97 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC17A5.08 34
  • 43.66 (n)
Species where no ortholog for TMED7 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMED7 Gene

Gene Tree for TMED7 (if available)
Gene Tree for TMED7 (if available)

Paralogs for TMED7 Gene

Paralogs for TMED7 Gene

(7) SIMAP similar genes for TMED7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TMED7: view

Variants for TMED7 Gene

Sequence variations from dbSNP and Humsavar for TMED7 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000002066 -- 115,615,435(+) TGTAA(C/T)GAGTA intron-variant, utr-variant-3-prime
rs1000272926 -- 115,619,220(+) AAATA(C/T)CATTT intron-variant
rs1001226481 -- 115,615,001(+) TAATA(C/T)TTGGA intron-variant, utr-variant-3-prime
rs1001251627 -- 115,628,176(+) TACAG(A/G)GGCAG upstream-variant-2KB
rs1001264664 -- 115,617,528(+) GAATG(A/G)AAAAT intron-variant

Variation tolerance for TMED7 Gene

Residual Variation Intolerance Score: 41.3% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMED7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMED7 Gene

Disorders for TMED7 Gene

Relevant External Links for TMED7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMED7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMED7 Gene

Publications for TMED7 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4 64
  2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Oligomeric state and stoichiometry of p24 proteins in the early secretory pathway. (PMID: 12237308) Jenne N. … Wieland F.T. (J. Biol. Chem. 2002) 3 4 64

Products for TMED7 Gene

Sources for TMED7 Gene

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