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Aliases for TMED6 Gene

Aliases for TMED6 Gene

  • Transmembrane Emp24 Protein Transport Domain Containing 6 2 3
  • P24 Family Protein Gamma-5 3 4
  • P24gamma5 3 4
  • Transmembrane Emp24 Domain-Containing Protein 6 3
  • PRO34237 3
  • SPLL9146 3

External Ids for TMED6 Gene

Previous GeneCards Identifiers for TMED6 Gene

  • GC16M067935
  • GC16M069377
  • GC16M055254

Summaries for TMED6 Gene

GeneCards Summary for TMED6 Gene

TMED6 (Transmembrane Emp24 Protein Transport Domain Containing 6) is a Protein Coding gene. An important paralog of this gene is ENSG00000259900.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMED6 Gene

Genomics for TMED6 Gene

Regulatory Elements for TMED6 Gene

Genomic Location for TMED6 Gene

69,343,246 bp from pter
69,351,809 bp from pter
8,564 bases
Minus strand

Genomic View for TMED6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMED6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMED6 Gene

Proteins for TMED6 Gene

  • Protein details for TMED6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane emp24 domain-containing protein 6
    Protein Accession:
    Secondary Accessions:
    • Q6UXN5

    Protein attributes for TMED6 Gene

    240 amino acids
    Molecular mass:
    27631 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMED6 Gene

Proteomics data for TMED6 Gene at MOPED

Post-translational modifications for TMED6 Gene

  • Glycosylation at Asn107 and Asn156
  • Modification sites at PhosphoSitePlus

Other Protein References for TMED6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMED6 Gene

Domains for TMED6 Gene

Protein Domains for TMED6 Gene


Suggested Antigen Peptide Sequences for TMED6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8WW62
  • Contains 1 GOLD domain.
  • Belongs to the EMP24/GP25L family.
genes like me logo Genes that share domains with TMED6: view

No data available for Gene Families for TMED6 Gene

Function for TMED6 Gene

Phenotypes for TMED6 Gene

GenomeRNAi human phenotypes for TMED6:
genes like me logo Genes that share phenotypes with TMED6: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMED6

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TMED6 Gene

Localization for TMED6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMED6 Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for TMED6 Gene COMPARTMENTS Subcellular localization image for TMED6 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 2
lysosome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TMED6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMED6: view

Pathways for TMED6 Gene

SuperPathways for TMED6 Gene

No Data Available

Interacting Proteins for TMED6 Gene

Gene Ontology (GO) - Biological Process for TMED6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with TMED6: view

No data available for Pathways by source for TMED6 Gene

Transcripts for TMED6 Gene

mRNA/cDNA for TMED6 Gene

(19) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMED6 Gene

Transmembrane emp24 protein transport domain containing 6:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMED6

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMED6 Gene

No ASD Table

Relevant External Links for TMED6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMED6 Gene

mRNA expression in normal human tissues for TMED6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMED6 Gene

This gene is overexpressed in Pancreas (29.5) and Stomach (10.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TMED6 Gene

SOURCE GeneReport for Unigene cluster for TMED6 Gene Hs.729118

genes like me logo Genes that share expressions with TMED6: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TMED6 Gene

Orthologs for TMED6 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMED6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 36
  • 100 (a)
TMED6 35
  • 99.58 (n)
  • 99.58 (a)
(Bos Taurus)
Mammalia TMED6 35
  • 88.47 (n)
  • 85.83 (a)
TMED6 36
  • 86 (a)
(Canis familiaris)
Mammalia -- 36
  • 90 (a)
TMED6 35
  • 89.03 (n)
  • 90.42 (a)
(Mus musculus)
Mammalia Tmed6 35
  • 81.45 (n)
  • 77.82 (a)
Tmed6 16
Tmed6 36
  • 78 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 74 (a)
(Rattus norvegicus)
Mammalia Tmed6 35
  • 81.79 (n)
  • 78.99 (a)
(Gallus gallus)
Aves -- 36
  • 66 (a)
TMED6 35
  • 69.15 (n)
  • 67.11 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmed6 35
  • 66.22 (n)
  • 63.06 (a)
(Danio rerio)
Actinopterygii LOC101884766 35
  • 57.62 (n)
  • 49.75 (a)
TMED6 36
  • 43 (a)
fruit fly
(Drosophila melanogaster)
Insecta loj 36
  • 25 (a)
Species with no ortholog for TMED6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMED6 Gene

Gene Tree for TMED6 (if available)
Gene Tree for TMED6 (if available)

Paralogs for TMED6 Gene

Paralogs for TMED6 Gene

genes like me logo Genes that share paralogs with TMED6: view

Variants for TMED6 Gene

Sequence variations from dbSNP and Humsavar for TMED6 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs153060 -- 69,343,650(+) GAGAG(A/G)GACAA intron-variant
rs410560 -- 69,348,487(-) ccgct(C/T)cccac intron-variant
rs411120 -- 69,348,488(-) cccgc(A/T)cccca intron-variant
rs826996 -- 69,344,899(-) gttgg(C/T)caggc intron-variant
rs826997 -- 69,344,887(-) ggtct(C/T)gaact intron-variant

Relevant External Links for TMED6 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMED6 Gene

Disorders for TMED6 Gene

No disorders were found for TMED6 Gene.

No data available for UniProtKB/Swiss-Prot for TMED6 Gene

Publications for TMED6 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for TMED6 Gene

Sources for TMED6 Gene

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