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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMED6 Gene

protein-coding   GIFtS: 40
GCID: GC16M069377

Transmembrane Emp24 Protein Transport Domain Containing...

  Search for TMED6
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transmembrane Emp24 Protein Transport Domain Containing 61 2
P24 Family Protein Gamma-52 3
p24gamma52 3
PRO342372
SPLL91462
Transmembrane Emp24 Domain-Containing Protein 62

External Ids:    HGNC: 283311   Entrez Gene: 1464562   Ensembl: ENSG000001573157   UniProtKB: Q8WW623   

Export aliases for TMED6 gene to outside databases

Previous GC identifers: GC16M067935 GC16M055254


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TMED6 Gene: 
TMED6 (transmembrane emp24 protein transport domain containing 6) is a protein-coding gene. An important paralog of this gene is ENSG00000259900.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMED6 gene promoter:
         RP58   p53   POU3F1   Nkx2-2   c-Myb   IRF-7A   POU6F1 (c2)   LCR-F1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMED6 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMED6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMED6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.1

TMED6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMED6 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M069377:  view genomic region     (about GC identifiers)

Start:
69,377,149 bp from pter      End:
69,385,712 bp from pter
Size:
8,564 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TMED6_HUMAN, Q8WW62 (See protein sequence)
Recommended Name: Transmembrane emp24 domain-containing protein 6 precursor  
Size: 240 amino acids; 27631 Da
Subcellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein (By similarity)
Secondary accessions: Q6UXN5

Explore the universe of human proteins at neXtProt for TMED6: NX_Q8WW62

Explore proteomics data for TMED6 at MOPED 

TMED6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

TMED6 Protein Expression

REFSEQ proteins: NP_653277.2  
ENSEMBL proteins: 
 ENSP00000288025  

Human Recombinant Protein Products for TMED6: 
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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005789endoplasmic reticulum membrane IEA--
GO:0016021integral to membrane IEA--

TMED6 for ontologies           About GeneDecksing



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Cloud-Clone Corp. CLIAs for TMED6


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro protein domain:
 IPR009038 GOLD

Graphical View of Domain Structure for InterPro Entry Q8WW62

ProtoNet protein and cluster: Q8WW62

1 Blocks protein domain: IPB000348 emp24/gp25L/p24 family

UniProtKB/Swiss-Prot: TMED6_HUMAN, Q8WW62
Similarity: Belongs to the EMP24/GP25L family
Similarity: Contains 1 GOLD domain


TMED6 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Phenotypes:
     1 GenomeRNAi human phenotype for TMED6:
 Decreased Wnt reporter activit 

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for TMED6 
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section




Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMED6

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006810transport IEA--

TMED6 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TMED6

Search CenterWatch for drugs/clinical trials and news about TMED6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TMED6 gene: 
NM_144676.3  

Unigene Cluster for TMED6:

Transmembrane emp24 protein transport domain containing 6
Hs.729118  [show with all ESTs]
Unigene Representative Sequence: FY213905
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000288025(uc002exc.2) ENST00000568748
miRNA
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Inhib. RNA
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Additional mRNA sequence: 

AY358268.1 BC020827.1 

3 DOTS entries:

DT.107080  DT.95157813  DT.97839393 

19 AceView cDNA sequences:

AA704690 AA894847 AA804957 NM_144676 BU949364 AY358268 AI244340 CA848118 
BG618673 BC020827 AA708152 BI600655 CA848396 BU949502 BU949125 BI910585 
H63184 CB164455 H63098 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TMED6 expression in normal human tissues (normalized intensities)      TMED6 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TGGCGATACT
TMED6 Expression
About this image


TMED6 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/2 selected tissues (see all 2) fully expand
 
 Kidney (Urinary System)
         Ureteric Bud
 
 Pancreas (Endocrine System)

See TMED6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMED6

SOURCE GeneReport for Unigene cluster: Hs.729118
    SABiosciences Custom PCR Arrays for TMED6
Primer
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMED6
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMED6

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TMED6 gene from 5/11 species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tmed61 , 5 transmembrane emp24 protein transport domain containing more1, 5 81.45(n)1
77.82(a)1
  8 (53.58 cM)5
662691  NM_025458.21  NP_079734.11 
 1070614845 
chicken
(Gallus gallus)
Aves TMED66
Uncharacterized protein
65(a)
1 → many
11(18380395-18382865)
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
62(a)
1 → many
GL343643.1(50542-53248)
zebrafish
(Danio rerio)
Actinopterygii CU207301.116
Uncharacterized protein
41(a)
1 → many
25(38300119-38302460)
fruit fly
(Drosophila melanogaster)
Insecta loj6
logjam
24(a)
1 → many
3L(6088087-6089617)


ENSEMBL Gene Tree for TMED6 (if available)
TreeFam Gene Tree for TMED6 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for TMED6 gene
ENSG000002599002  

TMED6 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/251 SNPs in TMED6 are shown (see all 251)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs767310001,2
C,F--69377527(+) TCTGCA/TCCTTT 2 E V mis11Minor allele frequency- T:0.02WA 118
rs1530601,2
C,F,O,H--69377553(+) GAGAGA/GGACAA 1 -- int136Minor allele frequency- G:0.30EA NA NS WA 5020
rs757200931,2
C,F--69377556(+) AGAGAC/GAATTT 1 -- int11Minor allele frequency- G:0.02WA 118
rs1402336801,2
C--69377580(+) TCCAAA/GCCCCC 1 -- int10--------
rs169587731,2
C,F--69377660(+) AAGATG/CTACAA 1 -- int14Minor allele frequency- C:0.03NA WA 256
rs1902683971,2
--69377724(+) TTTGAG/TTTTAA 1 -- int10--------
rs1441044731,2
--69377803(+) CACAGC/TTCACT 1 -- int10--------
rs1816651181,2
--69377826(+) TTCTGC/TGCTCA 1 -- int10--------
rs802540571,2
C,F--69377827(+) TCTGCG/ACTCAA 1 -- int11Minor allele frequency- A:0.03EA 120
rs1997793651,2
C--69377881(+) CACATC/GCCACT 1 -- int10--------

HapMap Linkage Disequilibrium report for TMED6 (69377149 - 69385712 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for TMED6: --
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing TMED6
DNA2.0 Custom Variant and Variant Library Synthesis for TMED6

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TMED6 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMED6)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 146456 HGNC: 28331 AceView: MGC23911 Ensembl:ENSG00000157315 euGenes: HUgn146456
ECgene: TMED6 H-InvDB: TMED6

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for TMED6 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for TMED6 gene:
Search GeneIP for patents involving TMED6

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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 SwitchGear 3'UTR luciferase reporter plasmids for TMED6
 SwitchGear Promoter luciferase reporter plasmids for TMED6
 Search ThermoFisher Antibodies for TMED6
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMED6
 inGenious Targeting Laboratory - Custom generated mouse model solutions for TMED6
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TMED6
Customized:
 lentivirus for stable overexpression of TMED6
 lentivirus expression plasmids for stable overexpression of TMED6
 adenovirus for overexpression of TMED6
 LSBio Antibodies in human, mouse, rat for TMED6
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
       
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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