TMED6 Gene
protein-coding GIFtS: 38
GCID: GC16M069377
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transmembrane emp24 protein transport domain containing...
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Aliases
for TMED6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Emp24 Protein Transport Domain Containing 61 2 | | PRO342372 | | P24 Family Protein Gamma-52 3 | | SPLL91462 | | P24gamma51 | | Transmembrane Emp24 Domain-Containing Protein 62 | | MGC239111 | | |
Export aliases for TMED6 gene to outside databasesPrevious GC identifers: GC16M067935 GC16M055254 |
Summaries
for TMED6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TMED6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010498.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMED6 gene promoter:
RP58 p53 POU3F1 Nkx2-2 c-Myb IRF-7A POU6F1 (c2) LCR-F1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMED6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMED6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q22.1 Ensembl cytogenetic band: 16q22.1 HGNC cytogenetic band: 16q22.1TMED6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M069377: view genomic region
(about GC identifiers)
Start:
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69,377,149 bp from pter |
End:
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69,385,712 bp from pter |
Size:
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8,564 bases |
Orientation:
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minus strand |
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Proteins
for TMED6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TMED6_HUMAN, Q8WW62 (See
protein sequence)Recommended Name: Transmembrane emp24 domain-containing protein 6 precursor Size: 240 amino acids; 27631 Da
Subcellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein (By similarity)
Secondary accessions: Q6UXN5Explore the universe of human proteins at neXtProt for TMED6: NX_Q8WW62
TMED6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_653277.2
ENSEMBL proteins: ENSP00000288025
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005789 | endoplasmic reticulum membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
TMED6 for ontologies About GeneDecksing
TMED6 Antibody Products:
Assay Products for TMED6: |
Protein
Domains /
Families
for TMED6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMED6 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8WW62ProtoNet protein and cluster: Q8WW62 1 Blocks protein family: IPB000348 emp24/gp25L/p24 family
UniProtKB/Swiss-Prot: TMED6_HUMAN, Q8WW62Similarity: Belongs to the EMP24/GP25L familySimilarity: Contains 1 GOLD domain |
Function
for TMED6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMED6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMED6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TMED6 (NM_144676) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMED6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMED6 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMED6 |
1 GenomeRNAi human phenotype for TMED6:
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Pathways & Interactions
for TMED6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMED6
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006810 | transport |
IEA | -- |
TMED6 for ontologies About GeneDecksing
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Drugs & Compounds
for TMED6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMED6
Search CenterWatch for drugs/clinical trials and news about TMED6
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Transcripts
for TMED6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMED6 gene: NM_144676.3 Unigene Cluster for TMED6: Transmembrane emp24 protein transport domain containing 6 Hs.729118 [show with all ESTs]Unigene Representative Sequence: FY2139052 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000288025(uc002exc.2) ENST00000568748
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMED6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMED6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TMED6 (NM_144676) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMED6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMED6 |
Additional cDNA sequence: AY358268.1 BC020827.1 3 DOTS entries: DT.107080 DT.95157813 DT.97839393 19 AceView cDNA sequences: AA704690 AA894847 AA804957 BU949364 NM_144676 BG618673 BC020827 BI600655 AY358268 CA848118 AI244340 AA708152 BI910585 BU949125 CA848396 BU949502 CB164455 H63184 H63098
GeneLoc Exon Structure
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Expression
for TMED6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMED6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGCGATACT
About this image
See TMED6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMED6
SOURCE GeneReport for Unigene cluster: Hs.729118
SABiosciences Custom PCR Arrays for TMED6
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMED6
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMED6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMED6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMED6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMED6 |
Orthologs
for TMED6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for TMED6 gene from 5/14 species (see all 14) About this table
ENSEMBL Gene Tree for TMED6 (if available)
TreeFam Gene Tree for TMED6 (if available) |
Paralogs
for TMED6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TMED6 gene
- ENSG000002599002
TMED6 for paralogs About GeneDecksing
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Genomic Variants
for TMED6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for TMED6 (69377149 - 69385712 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TMED6: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMED6 |
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Disorders
/ Diseases
for TMED6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for TMED6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMED6 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMED6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
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External Searches for TMED6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing TMED6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing TMED6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMED6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMED6 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for TMED6 gene:
Search GeneIP for patents involving TMED6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMED6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TMED6 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMED6 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMED6 | | | OriGene Protein Over-expression Lysate for TMED6 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMED6 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMED6 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMED6 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TMED6 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TMED6 | | OriGene Custom Protein Services for TMED6 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMED6 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMED6 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMED6 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMED6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMED6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMED6 |
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 |  |  |  | |
| | | | Search Tocris compounds for TMED6 |
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 | | | TMED6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMED6 |
|  |  |  | | | | Search ThermoFisher Antibodies for TMED6 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMED6 |
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