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Aliases for TMED5 Gene

Aliases for TMED5 Gene

  • Transmembrane P24 Trafficking Protein 5 2 3 5
  • Transmembrane Emp24 Protein Transport Domain Containing 5 2 3
  • P24 Family Protein Gamma-2 3 4
  • P24gamma2 3 4
  • P28 3 4
  • Transmembrane Emp24 Domain-Containing Protein 5 3
  • CGI-100 3
  • P24g2 3

External Ids for TMED5 Gene

Previous GeneCards Identifiers for TMED5 Gene

  • GC01M093330
  • GC01M093615
  • GC01M091736

Summaries for TMED5 Gene

GeneCards Summary for TMED5 Gene

TMED5 (Transmembrane P24 Trafficking Protein 5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and WNT ligand biogenesis and trafficking. An important paralog of this gene is TMED1.

UniProtKB/Swiss-Prot for TMED5 Gene

  • Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably not required for COPI-vesicle-mediated retrograde transport.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMED5 Gene

Genomics for TMED5 Gene

Regulatory Elements for TMED5 Gene

Enhancers for TMED5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F093124 0.4 Ensembl 11.5 +55.8 55828 0.2 ZNF316 ZNF837 HLF BACH1 POU5F1 EMSY TMED5 CCDC18 CCDC18-AS1 GC01P093147 MTF2
GH01F093122 0.6 ENCODE 11.5 +57.4 57353 1.6 JUND GLIS1 ZBTB33 TMED5 CCDC18 GC01P093147 MTF2
GH01F093221 0.4 ENCODE 11.3 -41.4 -41416 1.1 MLX DMAP1 RAD21 ZEB1 RARA ZNF366 CREM MIXL1 THAP11 ZNF362 CCDC18 TMED5 MTF2 ENSG00000225297 LOC100130531
GH01F093219 0.7 Ensembl 11 -39.0 -38973 0.6 TMED5 CCDC18 MTF2 FNBP1L ENSG00000225297 LOC100130531
GH01F093078 0.6 ENCODE 10.9 +100.3 100293 4.5 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 CCDC18-AS1 SNORA66 SNORD21 RPL5 DNTTIP2 DR1 LOC100289500 ACTBP12 MTCO3P21 ENSG00000230439
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TMED5 on UCSC Golden Path with GeneCards custom track

Promoters for TMED5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000540842 928 4801 PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF302 ZNF416

Genomic Location for TMED5 Gene

Chromosome:
1
Start:
93,149,742 bp from pter
End:
93,180,728 bp from pter
Size:
30,987 bases
Orientation:
Minus strand

Genomic View for TMED5 Gene

Genes around TMED5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMED5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMED5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMED5 Gene

Proteins for TMED5 Gene

  • Protein details for TMED5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3A6-TMED5_HUMAN
    Recommended name:
    Transmembrane emp24 domain-containing protein 5
    Protein Accession:
    Q9Y3A6
    Secondary Accessions:
    • B1AKT4
    • B2R703
    • D3DT38
    • Q96AX8

    Protein attributes for TMED5 Gene

    Size:
    229 amino acids
    Molecular mass:
    26005 Da
    Quaternary structure:
    • Interacts with TMED9 and TMED10.

    Alternative splice isoforms for TMED5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMED5 Gene

Post-translational modifications for TMED5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMED5 Gene

No data available for DME Specific Peptides for TMED5 Gene

Domains & Families for TMED5 Gene

Gene Families for TMED5 Gene

Protein Domains for TMED5 Gene

Suggested Antigen Peptide Sequences for TMED5 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y3A6

UniProtKB/Swiss-Prot:

TMED5_HUMAN :
  • Contains 1 GOLD domain.
  • Belongs to the EMP24/GP25L family.
Domain:
  • Contains 1 GOLD domain.
Family:
  • Belongs to the EMP24/GP25L family.
genes like me logo Genes that share domains with TMED5: view

Function for TMED5 Gene

Molecular function for TMED5 Gene

UniProtKB/Swiss-Prot Function:
Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably not required for COPI-vesicle-mediated retrograde transport.

Gene Ontology (GO) - Molecular Function for TMED5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23455924
genes like me logo Genes that share ontologies with TMED5: view
genes like me logo Genes that share phenotypes with TMED5: view

Animal Model Products

miRNA for TMED5 Gene

miRTarBase miRNAs that target TMED5

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TMED5

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMED5 Gene

Localization for TMED5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMED5 Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Note=Probably cycles between compartments of the early secretatory pathway.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMED5 Gene COMPARTMENTS Subcellular localization image for TMED5 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 3
extracellular 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TMED5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IDA 15308636
GO:0005794 Golgi apparatus IEA --
GO:0005801 cis-Golgi network IDA 19948005
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TMED5: view

Pathways & Interactions for TMED5 Gene

genes like me logo Genes that share pathways with TMED5: view

Pathways by source for TMED5 Gene

Gene Ontology (GO) - Biological Process for TMED5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
GO:0090161 Golgi ribbon formation IMP 19948005
genes like me logo Genes that share ontologies with TMED5: view

No data available for SIGNOR curated interactions for TMED5 Gene

Transcripts for TMED5 Gene

Unigene Clusters for TMED5 Gene

Transmembrane emp24 protein transport domain containing 5:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TMED5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMED5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: -
SP2: -
SP3: - -
SP4: -

Relevant External Links for TMED5 Gene

GeneLoc Exon Structure for
TMED5
ECgene alternative splicing isoforms for
TMED5

Expression for TMED5 Gene

mRNA expression in normal human tissues for TMED5 Gene

Protein differential expression in normal tissues from HIPED for TMED5 Gene

This gene is overexpressed in Islet of Langerhans (10.2) and NK cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMED5 Gene



Protein tissue co-expression partners for TMED5 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMED5 Gene:

TMED5

SOURCE GeneReport for Unigene cluster for TMED5 Gene:

Hs.482873
genes like me logo Genes that share expression patterns with TMED5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMED5 Gene

Orthologs for TMED5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TMED5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMED5 34 35
  • 99.85 (n)
cow
(Bos Taurus)
Mammalia TMED5 34 35
  • 92.63 (n)
dog
(Canis familiaris)
Mammalia TMED5 34 35
  • 92.58 (n)
rat
(Rattus norvegicus)
Mammalia Tmed5 34
  • 89.52 (n)
mouse
(Mus musculus)
Mammalia Tmed5 34 16 35
  • 89.08 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMED5 35
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMED5 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMED5 34 35
  • 85.44 (n)
lizard
(Anolis carolinensis)
Reptilia TMED5 35
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmed5 34
  • 70.13 (n)
Str.2055 34
zebrafish
(Danio rerio)
Actinopterygii tmed5 34 35
  • 67.32 (n)
zgc63936 34
fruit fly
(Drosophila melanogaster)
Insecta opm 34 35
  • 52.18 (n)
CG31787 35
  • 31 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001505 34
  • 50.44 (n)
worm
(Caenorhabditis elegans)
Secernentea K08E4.6 34 35
  • 49.91 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EMP24 35
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10421 35
  • 51 (a)
OneToMany
Species where no ortholog for TMED5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMED5 Gene

ENSEMBL:
Gene Tree for TMED5 (if available)
TreeFam:
Gene Tree for TMED5 (if available)

Paralogs for TMED5 Gene

Paralogs for TMED5 Gene

(3) SIMAP similar genes for TMED5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TMED5: view

Variants for TMED5 Gene

Sequence variations from dbSNP and Humsavar for TMED5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1057256 -- 93,155,784(+) ATGAT(A/T)TCATT intron-variant
rs1057257 -- 93,155,926(+) AAAAT(A/G)GTTGT intron-variant
rs10572798 -- 93,156,808(+) GTCTC(-/A)AAAAA intron-variant
rs1060622 -- 93,154,836(-) ACAAA(C/T)TCTGC nc-transcript-variant, reference, synonymous-codon, missense
rs1064797 -- 93,153,739(-) AAATA(C/T)TGCTA nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TMED5 Gene

Variant ID Type Subtype PubMed ID
nsv1008602 CNV gain 25217958
nsv830614 CNV loss 17160897
nsv830625 CNV loss 17160897

Variation tolerance for TMED5 Gene

Residual Variation Intolerance Score: 46.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.78; 96.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMED5 Gene

Human Gene Mutation Database (HGMD)
TMED5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMED5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMED5 Gene

Disorders for TMED5 Gene

Relevant External Links for TMED5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMED5

No disorders were found for TMED5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMED5 Gene

Publications for TMED5 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4 64
  2. p28, a novel ERGIC/cis Golgi protein, required for Golgi ribbon formation. (PMID: 19948005) Koegler E. … Hauri H.P. (Traffic 2010) 3 4 64
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64

Products for TMED5 Gene

Sources for TMED5 Gene

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