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Aliases for TMED5 Gene

Aliases for TMED5 Gene

  • Transmembrane P24 Trafficking Protein 5 2 3 5
  • Transmembrane Emp24 Protein Transport Domain Containing 5 2 3
  • P24 Family Protein Gamma-2 3 4
  • P24gamma2 3 4
  • P28 3 4
  • CGI-100 3
  • P24g2 3

External Ids for TMED5 Gene

Previous GeneCards Identifiers for TMED5 Gene

  • GC01M093330
  • GC01M093615
  • GC01M091736

Summaries for TMED5 Gene

GeneCards Summary for TMED5 Gene

TMED5 (Transmembrane P24 Trafficking Protein 5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by Wnt. An important paralog of this gene is TMED7-TICAM2.

UniProtKB/Swiss-Prot for TMED5 Gene

  • Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably not required for COPI-vesicle-mediated retrograde transport.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMED5 Gene

Genomics for TMED5 Gene

Regulatory Elements for TMED5 Gene

Promoters for TMED5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMED5 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMED5 Gene

Chromosome:
1
Start:
93,149,742 bp from pter
End:
93,180,728 bp from pter
Size:
30,987 bases
Orientation:
Minus strand

Genomic View for TMED5 Gene

Genes around TMED5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMED5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMED5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMED5 Gene

Proteins for TMED5 Gene

  • Protein details for TMED5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3A6-TMED5_HUMAN
    Recommended name:
    Transmembrane emp24 domain-containing protein 5
    Protein Accession:
    Q9Y3A6
    Secondary Accessions:
    • B1AKT4
    • B2R703
    • D3DT38
    • Q96AX8

    Protein attributes for TMED5 Gene

    Size:
    229 amino acids
    Molecular mass:
    26005 Da
    Quaternary structure:
    • Interacts with TMED9 and TMED10.

    Alternative splice isoforms for TMED5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMED5 Gene

Proteomics data for TMED5 Gene at MOPED

Post-translational modifications for TMED5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMED5 Gene

Antibody Products

No data available for DME Specific Peptides for TMED5 Gene

Domains & Families for TMED5 Gene

Gene Families for TMED5 Gene

Protein Domains for TMED5 Gene

Suggested Antigen Peptide Sequences for TMED5 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y3A6

UniProtKB/Swiss-Prot:

TMED5_HUMAN :
  • Contains 1 GOLD domain.
  • Belongs to the EMP24/GP25L family.
Domain:
  • Contains 1 GOLD domain.
Family:
  • Belongs to the EMP24/GP25L family.
genes like me logo Genes that share domains with TMED5: view

Function for TMED5 Gene

Molecular function for TMED5 Gene

UniProtKB/Swiss-Prot Function:
Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably not required for COPI-vesicle-mediated retrograde transport.
genes like me logo Genes that share phenotypes with TMED5: view

Animal Model Products

miRNA for TMED5 Gene

miRTarBase miRNAs that target TMED5

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMED5 Gene

Localization for TMED5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMED5 Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Note=Probably cycles between compartments of the early secretatory pathway.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMED5 Gene COMPARTMENTS Subcellular localization image for TMED5 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 3
extracellular 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TMED5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IDA 15308636
GO:0016021 integral component of membrane IEA --
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane IEA --
GO:0070971 endoplasmic reticulum exit site IDA 19948005
genes like me logo Genes that share ontologies with TMED5: view

Pathways & Interactions for TMED5 Gene

genes like me logo Genes that share pathways with TMED5: view

Pathways by source for TMED5 Gene

Interacting Proteins for TMED5 Gene

Gene Ontology (GO) - Biological Process for TMED5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with TMED5: view

No data available for SIGNOR curated interactions for TMED5 Gene

Drugs & Compounds for TMED5 Gene

No Compound Related Data Available

Transcripts for TMED5 Gene

Unigene Clusters for TMED5 Gene

Transmembrane emp24 protein transport domain containing 5:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMED5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: -
SP2: -
SP3: - -
SP4: -

Relevant External Links for TMED5 Gene

GeneLoc Exon Structure for
TMED5
ECgene alternative splicing isoforms for
TMED5

Expression for TMED5 Gene

mRNA expression in normal human tissues for TMED5 Gene

Protein differential expression in normal tissues from HIPED for TMED5 Gene

This gene is overexpressed in Islet of Langerhans (10.2) and NK cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMED5 Gene



SOURCE GeneReport for Unigene cluster for TMED5 Gene Hs.482873

genes like me logo Genes that share expression patterns with TMED5: view

Protein tissue co-expression partners for TMED5 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMED5 Gene

Orthologs for TMED5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TMED5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMED5 35
  • 99.85 (n)
  • 99.56 (a)
TMED5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMED5 36
  • 97 (a)
OneToOne
TMED5 35
  • 92.63 (n)
  • 96.02 (a)
dog
(Canis familiaris)
Mammalia TMED5 35
  • 92.58 (n)
  • 93.89 (a)
TMED5 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmed5 16
Tmed5 36
  • 90 (a)
OneToOne
Tmed5 35
  • 89.08 (n)
  • 89.96 (a)
oppossum
(Monodelphis domestica)
Mammalia TMED5 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMED5 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmed5 35
  • 89.52 (n)
  • 90.39 (a)
chicken
(Gallus gallus)
Aves TMED5 36
  • 85 (a)
OneToOne
TMED5 35
  • 85.44 (n)
  • 87.86 (a)
lizard
(Anolis carolinensis)
Reptilia TMED5 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.2055 35
tmed5 35
  • 70.13 (n)
  • 73.27 (a)
zebrafish
(Danio rerio)
Actinopterygii tmed5 36
  • 65 (a)
OneToOne
tmed5 35
  • 67.32 (n)
  • 71.57 (a)
zgc63936 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001505 35
  • 50.44 (n)
  • 39.79 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31787 36
  • 31 (a)
ManyToMany
opm 36
  • 38 (a)
ManyToMany
opm 35
  • 52.18 (n)
  • 43.98 (a)
worm
(Caenorhabditis elegans)
Secernentea K08E4.6 35
  • 49.91 (n)
  • 43.98 (a)
K08E4.6 36
  • 36 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EMP24 36
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10421 36
  • 51 (a)
OneToMany
Species with no ortholog for TMED5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMED5 Gene

ENSEMBL:
Gene Tree for TMED5 (if available)
TreeFam:
Gene Tree for TMED5 (if available)

Paralogs for TMED5 Gene

Paralogs for TMED5 Gene

(3) SIMAP similar genes for TMED5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TMED5: view

Variants for TMED5 Gene

Sequence variations from dbSNP and Humsavar for TMED5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1060622 - 93,154,836(-) ACAAA(C/T)TCTGC nc-transcript-variant, reference, synonymous-codon, missense
rs3171 -- 93,151,920(+) TGTTT(A/G)TAAGT nc-transcript-variant, utr-variant-3-prime
rs1064797 -- 93,153,739(-) AAATA(C/T)TGCTA nc-transcript-variant, utr-variant-3-prime
rs1137728 -- 93,156,283(-) CTTCT(A/C)ATAAA intron-variant
rs1537756 -- 93,157,600(+) agtcc(A/T)agcta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMED5 Gene

Variant ID Type Subtype PubMed ID
nsv830614 CNV Loss 17160897
nsv830625 CNV Loss 17160897

Variation tolerance for TMED5 Gene

Residual Variation Intolerance Score: 46.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.78; 96.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMED5 Gene

HapMap Linkage Disequilibrium report
TMED5
Human Gene Mutation Database (HGMD)
TMED5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMED5 Gene

Disorders for TMED5 Gene

Relevant External Links for TMED5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMED5

No disorders were found for TMED5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMED5 Gene

Publications for TMED5 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. The I+-helical region in p24I^2 subunit of p24 protein cargo receptor is pivotal for the recognition and transport of glycosylphosphatidylinositol-anchored proteins. (PMID: 24778190) Theiler R. … Kinoshita T. (J. Biol. Chem. 2014) 3
  4. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3
  5. p28, a novel ERGIC/cis Golgi protein, required for Golgi ribbon formation. (PMID: 19948005) Koegler E. … Hauri H.P. (Traffic 2010) 3

Products for TMED5 Gene

Sources for TMED5 Gene

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