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TMED5 Gene

protein-coding   GIFtS: 54
GCID: GC01M093615

Transmembrane Emp24 Protein Transport Domain Containing...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Emp24 Protein Transport Domain Containing 51 2
P24 Family Protein Gamma-22 3
p24gamma22 3
p282 3
CGI-1002
Transmembrane Emp24 Domain-Containing Protein 52

External Ids:    HGNC: 242511   Entrez Gene: 509992   Ensembl: ENSG000001175007   UniProtKB: Q9Y3A63   

Export aliases for TMED5 gene to outside databases

Previous GC identifers: GC01M093330 GC01M091736


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMED5 Gene:
TMED5 (transmembrane emp24 protein transport domain containing 5) is a protein-coding gene. An important paralog of this gene is TICAM2.

UniProtKB/Swiss-Prot: TMED5_HUMAN, Q9Y3A6
Function: Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the
maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably
not required for COPI-vesicle-mediated retrograde transport




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMED5 gene promoter:
         STAT1   RFX1   Pax-5   IRF-1   HNF-3beta   YY1   MEF-2A   CREB   HSF2   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMED5 promoter sequence
   Search Chromatin IP Primers for TMED5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMED5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22.1   Ensembl cytogenetic band:  1p22.1   HGNC cytogenetic band: 1p22.1

TMED5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMED5 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M093615:  view genomic region     (about GC identifiers)

Start:
93,615,299 bp from pter      End:
93,646,285 bp from pter
Size:
30,987 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TMED5_HUMAN, Q9Y3A6 (See protein sequence)
Recommended Name: Transmembrane emp24 domain-containing protein 5 precursor  
Size: 229 amino acids; 26005 Da
Subunit: Interacts with TMED9 and TMED10
Secondary accessions: B1AKT4 B2R703 D3DT38 Q96AX8
Alternative splicing: 2 isoforms:  Q9Y3A6-1   Q9Y3A6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TMED5: NX_Q9Y3A6

Explore proteomics data for TMED5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TMED5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001161302.1  NP_057124.3  

    ENSEMBL proteins: 
     ENSP00000359305   ENSP00000471060   ENSP00000418992   ENSP00000359303  
    Reactome Protein details: Q9Y3A6

    TMED5 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for TMED5
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    Novus Biologicals TMED5 Protein
    Novus Biologicals TMED5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for TMED5

     
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    Search eBioscience for ELISAs for TMED5 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR009038 GOLD

    Graphical View of Domain Structure for InterPro Entry Q9Y3A6

    ProtoNet protein and cluster: Q9Y3A6

    1 Blocks protein domain: IPB000348 emp24/gp25L/p24 family

    UniProtKB/Swiss-Prot: TMED5_HUMAN, Q9Y3A6
    Similarity: Belongs to the EMP24/GP25L family
    Similarity: Contains 1 GOLD domain


    Find genes that share domains with TMED5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TMED5_HUMAN, Q9Y3A6
    Function: Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the
    maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably
    not required for COPI-vesicle-mediated retrograde transport

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with TMED5           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TMED5:
     Decreased cell number and incr 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMED5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TMED5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMED5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMED5

    miRNA
    Products:
        
    miRTarBase miRNAs that target TMED5:
    hsa-mir-30a-5p (MIRT028593), hsa-mir-652-3p (MIRT039509), hsa-let-7b-5p (MIRT032422), hsa-mir-26b-5p (MIRT029986), hsa-mir-375 (MIRT019961), hsa-mir-30b-5p (MIRT046138), hsa-mir-301a-3p (MIRT044231)

    Block miRNA regulation of human, mouse, rat TMED5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TMED5 (see all 82):
    hsa-miR-194* hsa-miR-579 hsa-miR-3130-5p hsa-miR-199a-3p hsa-miR-128 hsa-miR-374a hsa-miR-138-2* hsa-miR-10b*
    SwitchGear 3'UTR luciferase reporter plasmidTMED5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TMED5
    Predesigned siRNA for gene silencing in human, mouse, rat TMED5

    Gene Editing
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TMED5 (NM_016040)
    Sino Biological Human cDNA Clone for TMED5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMED5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMED5

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for TMED5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMED5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TMED5_HUMAN, Q9Y3A6: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus,
    cis-Golgi network membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate
    compartment membrane; Single-pass type I membrane protein. Note=Probably cycles between compartments of the early
    secretatory pathway
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    golgi apparatus3
    extracellular2
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005793endoplasmic reticulum-Golgi intermediate compartment IDA15308636
    GO:0005794Golgi apparatus IEA--
    GO:0005801cis-Golgi network IDA19948005
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TMED5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TMED5 About    
    See pathways by source

    SuperPathContained pathways About
    1beta-catenin independent WNT signaling
    Signaling by Wnt0.79
    2Signaling by GPCR
    Signal Transduction0.58
    3Wnt Pathway
    WNT ligand biogenesis and trafficking0.56


    Find genes that share SuperPaths with TMED5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for TMED5
        WNT ligand biogenesis and trafficking


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMED5
    Interactions:

        Search GeneGlobe Interaction Network for TMED5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TMED5 (Q9Y3A61, 2, 3 ENSP000003593054) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CLN3Q132863I2D: score=1 
    TFGQ927343I2D: score=1 
    LMAN1P492572MINT-8303209
    PRMT6Q96LA81EBI-7560959,EBI-912440
    TMED2ENSP000002622254STRING: ENSP00000262225
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0015031protein transport IEA--
    GO:0090161Golgi ribbon formation IMP19948005

    Find genes that share ontologies with TMED5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMED5



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TMED5 gene (2 alternative transcripts): 
    NM_001167830.1  NM_016040.4  

    Unigene Cluster for TMED5:

    Transmembrane emp24 protein transport domain containing 5
    Hs.482873  [show with all ESTs]
    Unigene Representative Sequence: NR_030761
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370282(uc001dpp.3 uc001dpo.3 uc001dpn.3) ENST00000370290
    ENST00000483033 ENST00000479918 ENST00000370280
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TMED5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TMED5 (see all 82):
    hsa-miR-194* hsa-miR-579 hsa-miR-3130-5p hsa-miR-199a-3p hsa-miR-128 hsa-miR-374a hsa-miR-138-2* hsa-miR-10b*
    SwitchGear 3'UTR luciferase reporter plasmidTMED5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TMED5
    Predesigned siRNA for gene silencing in human, mouse, rat TMED5
    Clone
    Products:
         
    OriGene clones in human, mouse for TMED5 (see all 11)
    OriGene ORF clones in mouse, rat for TMED5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TMED5 (NM_016040)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMED5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMED5
    Primer
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    OriGene qPCR primer pairs and template standards for TMED5
    OriGene qSTAR qPCR primer pairs in human, mouse for TMED5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMED5
      QuantiTect SYBR Green Assays in human, mouse, rat TMED5
      QuantiFast Probe-based Assays in human, mouse, rat TMED5

    Additional mRNA sequence: 

    AF151858.1 AK125882.1 AK293308.1 AK312787.1 AL080084.1 AY359039.1 BC016365.1 BC016556.1 
    BC023274.1 BC070051.1 BX537730.1 CR936808.1 NR_030761.1 

    19 DOTS entries:

    DT.421664  DT.447532  DT.97859085  DT.91799019  DT.91737464  DT.121451619  DT.100709267  DT.121451571 
    DT.95305076  DT.318088  DT.91737461  DT.95205150  DT.121451649  DT.91935902  DT.97782715  DT.100658108 
    DT.100821625  DT.102833304  DT.121350663 

    Selected AceView cDNA sequences (see all 361):

    BP351784 AW966873 H00335 AW300233 CR607162 D12073 AA772421 AA490349 
    BM452652 CD676998 BF797996 AW967497 AA662171 AA379717 CK904785 AI758374 
    AW235946 CR592267 BX090542 BM670726 CA393952 BE907581 AV652998 BP351275 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TMED5    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
    SP1:                          -                                 
    SP2:                                      -                     
    SP3:                          -           -                     
    SP4:                          -                                 


    ECgene alternative splicing isoforms for TMED5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMED5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAGGATTTT
    TMED5 Expression
    About this image

    TMED5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMED5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.482873
        Custom PCR Arrays for TMED5
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMED5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TMED5 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmed51 , 5 transmembrane emp24 protein transport domain containing more1, 5 89.08(n)1
    89.96(a)1
      5 (52.49 cM)5
    731301  NM_028876.21  NP_083152.11 
     1081063665 
    chicken
    (Gallus gallus)
    Aves TMED51 transmembrane emp24 protein transport domain containing more 85.44(n)
    87.86(a)
      424499  NM_001007956.1  NP_001007957.1 
    lizard
    (Anolis carolinensis)
    Reptilia TMED56
    transmembrane emp24 protein transport domain conta...
    82(a)
    1 ↔ 1
    4(88193284-88201981)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.20552 Transcribed sequence with moderate similarity to protein more 76.75(n)    BX718371.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc639362 hypothetical protein MGC63936 73.75(n)   393374  BC054575.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta opm1 opossum 52.18(n)
    43.98(a)
      32435  NM_132766.2  NP_572994.1 
    worm
    (Caenorhabditis elegans)
    Secernentea K08E4.61 K08E4.6 49.91(n)
    43.98(a)
      178145  NM_069887.3  NP_502288.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes EMP246
    Component of the p24 complex; binds to GPI anchor ...
    21(a)
    1 → many
    VII(122694-123305) YGL200C


    ENSEMBL Gene Tree for TMED5 (if available)
    TreeFam Gene Tree for TMED5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TMED5 gene
    TICAM22  TMED12  TMED7-TICAM22  TMED22  TMED32  TMED72  
    3 SIMAP similar genes for TMED5 using alignment to 4 protein entries:     TMED5_HUMAN (see all proteins):
    TMED1    TMED3    TMED7

    Find genes that share paralogs with TMED5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMED5 (see all 480)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1409297571,2
    C--93614917(+) GAATAC/TGATCC 3 -- int10--------
    rs1430619761,2
    --93614992(+) CACTTC/TGATGA 3 -- int10--------
    rs1512053591,2
    --93615081(+) ACCTAC/TTGAGG 3 -- int10--------
    rs1814904681,2
    --93615082(+) CCTATG/TGAGGA 3 -- int10--------
    rs1127704181,2
    C,F--93615089(+) AGGATC/TCCCAA 3 -- int12Minor allele frequency- T:0.02CSA WA 120
    rs1402777561,2
    --93615155(+) GATTAC/TCCGAA 3 -- int10--------
    rs1503886511,2
    --93615263(+) CCTCAC/TAAGGG 3 -- int10--------
    rs1859470871,2
    --93615479(+) GAGGCC/GGGCAC 3 -- ut31 nc-transcript-variant0--------
    rs1381970601,2
    --93615547(+) CAGAAA/GTATGT 3 -- ut31 nc-transcript-variant0--------
    rs1436904471,2
    --93615628(+) CCACAA/GTCAAA 3 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for TMED5 (93615299 - 93646285 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TMED5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830614CNV Loss17160897
    nsv830625CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TMED5
    DNA2.0 Custom Variant and Variant Library Synthesis for TMED5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMED5 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with TMED5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.-H.... Lin W.-C. (Genome Res. 2000)
    2. p28, a novel ERGIC/cis Golgi protein, required for Golgi ribbon formation. (PubMed id 19948005)1, 2 Koegler E....Hauri H.P. (Traffic 2010)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 50999 HGNC: 24251 AceView: CGI-100 Ensembl:ENSG00000117500 euGenes: HUgn50999
    ECgene: TMED5 H-InvDB: TMED5

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TMED5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMED5 gene:
    Search GeneIP for patents involving TMED5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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