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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMED4 Gene

protein-coding   GIFtS: 48
GCID: GC07M044584

Transmembrane Emp24 Protein Transport Domain Containing...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transmembrane Emp24 Protein Transport Domain Containing 41 2     HNLF2
Putative NF-Kappa-B-Activating Protein 1562 3     Endoplasmic Reticulum Stress-Response Protein 25 KDa2
ERS252 3     Putative NFkB Activating Protein HNLF2
GMP25iso2 3     Transmembrane Emp24 Domain-Containing Protein 42
P24 Family Protein Alpha-32 3     Endoplasmic Reticulum Stress-Response Protein 253
p24alpha32 3     

External Ids:    HGNC: 223011   Entrez Gene: 2220682   Ensembl: ENSG000001586047   OMIM: 6120385   UniProtKB: Q7Z7H53   

Export aliases for TMED4 gene to outside databases

Previous GC identifers: GC07M044391 GC07M044503


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TMED4 Gene: 
TMED4 (transmembrane emp24 protein transport domain containing 4) is a protein-coding gene. Diseases associated with TMED4 include bronchiolo-alveolar adenocarcinoma, and adenocarcinoma, and among its related super-pathways are TNF Signaling. GO annotations related to this gene include signal transducer activity. An important paralog of this gene is TMED9.

UniProtKB/Swiss-Prot: TMED4_HUMAN, Q7Z7H5
Function: Involved in vesicular protein trafficking, mainly in the early secretory pathway. targeting. Involved in
the maintenance of the Golgi apparatus. Appears to play a role in the biosynthesis of secreted cargo including
processing. Involved in endoplasmic reticulum stress response. May play a role in the regulation of heat-shock
response and apoptosis (By similarity)

Gene Wiki entry for TMED4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007819.17  NC_018918.2  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMED4 gene promoter:
         GR   AML1a   AP-1   MyoD   Nkx2-5   Tal-1beta   GATA-1   GR-alpha   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMED4 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMED4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMED4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p13   Ensembl cytogenetic band:  7p13   HGNC cytogenetic band: 7p13

TMED4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMED4 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M044584:  view genomic region     (about GC identifiers)

Start:
44,617,493 bp from pter      End:
44,621,886 bp from pter
Size:
4,394 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 44,658,279-44,661,344     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TMED4_HUMAN, Q7Z7H5 (See protein sequence)
Recommended Name: Transmembrane emp24 domain-containing protein 4 precursor  
Size: 227 amino acids; 25943 Da
Subcellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein (By similarity)
Sequence caution: Sequence=AAP20105.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAC77362.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A4D2K8 B4DFJ4 Q56VW3 Q7Z432 Q8N2P6
Alternative splicing: 3 isoforms:  Q7Z7H5-1   Q7Z7H5-2   Q7Z7H5-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TMED4: NX_Q7Z7H5

Explore proteomics data for TMED4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q7Z7H5

  • TMED4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TMED4 Protein Expression
    REFSEQ proteins: NP_872353.2  
    ENSEMBL proteins: 
     ENSP00000404042   ENSP00000289577   ENSP00000417443  

    Human Recombinant Protein Products for TMED4: 
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    OriGene Protein Over-expression Lysate for TMED4
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    Sino Biological Recombinant Protein for TMED4
    Sino Biological Cell Lysate for TMED4 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TMED4 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral to membrane IEA--

    TMED4 for ontologies           About GeneDecksing



    TMED4 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for TMED4 
    Cloud-Clone Corp. CLIAs for TMED4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR009038 GOLD

    Graphical View of Domain Structure for InterPro Entry Q7Z7H5

    ProtoNet protein and cluster: Q7Z7H5

    1 Blocks protein domain: IPB000348 emp24/gp25L/p24 family

    UniProtKB/Swiss-Prot: TMED4_HUMAN, Q7Z7H5
    Similarity: Belongs to the EMP24/GP25L family
    Similarity: Contains 1 GOLD domain


    TMED4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TMED4_HUMAN, Q7Z7H5
    Function: Involved in vesicular protein trafficking, mainly in the early secretory pathway. targeting. Involved in
    the maintenance of the Golgi apparatus. Appears to play a role in the biosynthesis of secreted cargo including
    processing. Involved in endoplasmic reticulum stress response. May play a role in the regulation of heat-shock
    response and apoptosis (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity IMP12761501
         
    TMED4 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TMED4:
     Decreased viability of wild-ty  Large nuclei 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TMED4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TMED4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMED4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMED4 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMED4
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate TMED4:
    hsa-miR-579 hsa-miR-3153
    SwitchGear 3'UTR luciferase reporter plasmidTMED4 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Clone
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    OriGene clones in human, mouse for TMED4 (see all 5)
    OriGene ORF clones in mouse, rat for TMED4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TMED4 (NM_182547)
    Sino Biological Human cDNA Clone for TMED4
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMED4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TMED4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1TNF Signaling
    NF-kB (NFkB) Pathway0.46


    1 Sino Biological Pathway for TMED4 
        NF-kB (NFkB) Pathway


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMED4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/7 Interacting proteins for TMED4 (ENSP000004040424) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KIAA0368ENSP000002593354STRING: ENSP00000259335
    UBCENSP000003448184STRING: ENSP00000344818
    TMED10ENSP000003031454STRING: ENSP00000303145
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    TMED2ENSP000002622254STRING: ENSP00000262225
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0007165signal transduction IMP12761501
    GO:0015031protein transport IEA--
    GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascade IMP12761501

    TMED4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMED4

    Search CenterWatch for drugs/clinical trials and news about TMED4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TMED4 gene: 
    NM_182547.2  

    Unigene Clusters for TMED4:

    Transmembrane emp24 protein transport domain containing 4
    Hs.598832  [show with all ESTs], Hs.715273  [show with all ESTs]
    Unigene Representative Sequences: BC035467, BC001576
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000457408(uc003tli.3) ENST00000289577 ENST00000481238(uc003tlk.3)
    ENST00000477639(uc003tlj.3) ENST00000444131
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMED4
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate TMED4:
    hsa-miR-579 hsa-miR-3153
    SwitchGear 3'UTR luciferase reporter plasmidTMED4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TMED4
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    Clone
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    GenScript: all cDNA clones in your preferred vector: TMED4 (NM_182547)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMED4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMED4
    Sirion Biotech Customized lentivirus for stable overexpression of TMED4 
                         Customized lentivirus expression plasmids for stable overexpression of TMED4 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TMED4
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMED4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMED4

    Additional mRNA sequence: 

    BC001576.1 BC045811.1 

    22 DOTS entries:

    DT.100886960  DT.448262  DT.101984218  DT.92452919  DT.92452912  DT.92452918  DT.100038316  DT.101980997 
    DT.92066887  DT.121116475  DT.100886972  DT.121116551  DT.121116474  DT.100886967  DT.99989216  DT.100717477 
    DT.121116470  DT.121116542  DT.95364252  DT.95364253  DT.95364243  DT.95364249 

    24/854 AceView cDNA sequences (see all 854):

    BQ549684 CA423604 AI554936 BM992460 CA416263 CD368996 BQ072359 BE908658 
    AA496801 BE295662 CR601138 BU786043 BM846185 BU166591 CR596036 BU069952 
    BG141339 BU509844 T49138 CA489126 BM827581 BM511814 AI184019 BQ349800 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TMED4 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7
    SP1:                    -                                   -     -                     
    SP2:                    -                                   -                           
    SP3:              -     -                                   -     -     -     -         
    SP4:              -     -     -                                                         
    SP5:                    -                             -     -     -                     


    ECgene alternative splicing isoforms for TMED4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMED4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TMED4 Expression
    About this image


    See TMED4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMED4

    SOURCE GeneReport for Unigene clusters: Hs.598832 Hs.715273
        SABiosciences Custom PCR Arrays for TMED4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMED4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TMED4 gene from 7/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmed41 , 5 transmembrane emp24 protein transport domain containing more1, 5 87.37(n)1
    94.71(a)1
      11 (3.94 cM)5
    1036941  NM_134020.11  NP_598781.11 
     62703695 
    chicken
    (Gallus gallus)
    Aves LOC1008594851 transmembrane emp24 domain-containing protein 4-like 83.91(n)
    95.98(a)
      100859485  XM_003643526.1  XP_003643574.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia CA971665.12   -- 78.29(n)    CA971665.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tmed41 transmembrane emp24 protein transport domain containing more 76.83(n)
    87.14(a)
      415224  NM_001002134.1  NP_001002134.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta eca1 eclair 70.19(n)
    71.15(a)
      41177  NM_176439.2  NP_788616.1 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_Y60A3A.91 Protein Y60A3A.9 62.18(n)
    68.75(a)
      180307  NM_075460.2  NP_507861.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ERP61 Erp6p 42.56(n)
    30.1(a)
      852882   NP_011513.1 


    ENSEMBL Gene Tree for TMED4 (if available)
    TreeFam Gene Tree for TMED4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TMED4 gene
    TMED92  
    5 SIMAP similar genes for TMED4 using alignment to 2 protein entries:     TMED4_HUMAN (see all proteins):
    TMED9    TMED10    TMED7    RNP24    TMED2

    TMED4 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TMED4
    PGOHUM00000250690


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/139 SNPs in TMED4 are shown (see all 139)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1848492141,2
    --44593768(+) TGAGCA/GTGGTG 1 -- int10--------
    rs1866110991,2
    --44593804(+) CAGGAA/GACTGA 1 -- int10--------
    rs174042801,2
    F--44593869(-) GTGCAA/GTGGCG 1 -- int11Minor allele frequency- G:0.32MN 184
    rs2173631,2
    C,F,A,H--44593890(-) gctctC/Tgtcgc 1 -- int1 ese37Minor allele frequency- T:0.29NA WA 14
    rs1385651431,2
    C--44593926(+) AAAAA-/A/GGGAAA 1 -- int10--------
    rs570052101,2
    C--44593927(+) AAAAGA/-GAAAA 1 -- int11Minor allele frequency- -:0.00NA 2
    rs1922083111,2
    --44593977(+) CTAGTC/TACAGG 1 -- int10--------
    rs2173621,2
    C,F,O,A,H--44594041(-) TTCTAT/AATCTT 1 -- int1 ese319Minor allele frequency- A:0.20MN NS EA NA WA CSA 1088
    rs1845343231,2
    C--44594062(+) ATCCTC/TTAGGG 1 -- int10--------
    rs47243121,2
    C,F,H--44594112(+) GTGAAC/GCCAGA 1 -- int1 ese326Minor allele frequency- G:0.14EA NA NS WA 2978

    HapMap Linkage Disequilibrium report for TMED4 (44617493 - 44621886 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TMED4: --
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing TMED4
    DNA2.0 Custom Variant and Variant Library Synthesis for TMED4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612038    OMIM disorders: --

    2 diseases for TMED4:    About MalaCards
    bronchiolo-alveolar adenocarcinoma    adenocarcinoma


    TMED4 for disorders           About GeneDecksing


    Export disorders for TMED4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMED4 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with TMED4)
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    world of online information

    1. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PubMed id 12761501)1, 2, 3 Matsuda A....Sugano S. (2003)
    2. Novel oxidative stress-responsive gene ERS25 functions as a regulator of the heat-shock and cell death response. (PubMed id 18326488)1, 2 Hwang S.O.... Lee S.W. (2008)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    7. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 222068 HGNC: 22301 AceView: DDX56andHNLF Ensembl:ENSG00000158604 euGenes: HUgn222068
    ECgene: TMED4 H-InvDB: TMED4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMED4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TMED4 gene:
    Search GeneIP for patents involving TMED4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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