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Aliases for TMED4 Gene

Aliases for TMED4 Gene

  • Transmembrane P24 Trafficking Protein 4 2 3 5
  • Transmembrane Emp24 Protein Transport Domain Containing 4 2 3
  • Putative NF-Kappa-B-Activating Protein 156 3 4
  • P24 Family Protein Alpha-3 3 4
  • P24alpha3 3 4
  • GMP25iso 3 4
  • ERS25 3 4
  • Endoplasmic Reticulum Stress-Response Protein 25 KDa 3
  • Endoplasmic Reticulum Stress-Response Protein 25 4
  • Putative NFkB Activating Protein HNLF 3
  • P24a3 3
  • HNLF 3

External Ids for TMED4 Gene

Previous GeneCards Identifiers for TMED4 Gene

  • GC07M044391
  • GC07M044584
  • GC07M044503
  • GC07M044617

Summaries for TMED4 Gene

GeneCards Summary for TMED4 Gene

TMED4 (Transmembrane P24 Trafficking Protein 4) is a Protein Coding gene. Among its related pathways are TNF Signaling (sino). GO annotations related to this gene include signal transducer activity. An important paralog of this gene is TMED9.

UniProtKB/Swiss-Prot for TMED4 Gene

  • Involved in vesicular protein trafficking, mainly in the early secretory pathway. targeting. Involved in the maintenance of the Golgi apparatus. Appears to play a role in the biosynthesis of secreted cargo including processing. Involved in endoplasmic reticulum stress response. May play a role in the regulation of heat-shock response and apoptosis (By similarity).

Gene Wiki entry for TMED4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMED4 Gene

Genomics for TMED4 Gene

Regulatory Elements for TMED4 Gene

Enhancers for TMED4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMED4 on UCSC Golden Path with GeneCards custom track

Promoters for TMED4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMED4 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMED4 Gene

Chromosome:
7
Start:
44,577,894 bp from pter
End:
44,582,295 bp from pter
Size:
4,402 bases
Orientation:
Minus strand

Genomic View for TMED4 Gene

Genes around TMED4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMED4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMED4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMED4 Gene

Proteins for TMED4 Gene

  • Protein details for TMED4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z7H5-TMED4_HUMAN
    Recommended name:
    Transmembrane emp24 domain-containing protein 4
    Protein Accession:
    Q7Z7H5
    Secondary Accessions:
    • A4D2K8
    • B4DFJ4
    • Q56VW3
    • Q7Z432
    • Q8N2P6

    Protein attributes for TMED4 Gene

    Size:
    227 amino acids
    Molecular mass:
    25943 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAP20105.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC77362.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMED4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMED4 Gene

Proteomics data for TMED4 Gene at MOPED

Post-translational modifications for TMED4 Gene

  • Ubiquitination at Lys 63, Lys 152, and Lys 172
  • Glycosylation at Asn 117
  • Modification sites at PhosphoSitePlus

Other Protein References for TMED4 Gene

No data available for DME Specific Peptides for TMED4 Gene

Domains & Families for TMED4 Gene

Gene Families for TMED4 Gene

Protein Domains for TMED4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TMED4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z7H5

UniProtKB/Swiss-Prot:

TMED4_HUMAN :
  • Contains 1 GOLD domain.
  • Belongs to the EMP24/GP25L family.
Domain:
  • Contains 1 GOLD domain.
Family:
  • Belongs to the EMP24/GP25L family.
genes like me logo Genes that share domains with TMED4: view

Function for TMED4 Gene

Molecular function for TMED4 Gene

UniProtKB/Swiss-Prot Function:
Involved in vesicular protein trafficking, mainly in the early secretory pathway. targeting. Involved in the maintenance of the Golgi apparatus. Appears to play a role in the biosynthesis of secreted cargo including processing. Involved in endoplasmic reticulum stress response. May play a role in the regulation of heat-shock response and apoptosis (By similarity).
genes like me logo Genes that share phenotypes with TMED4: view

Animal Model Products

miRNA for TMED4 Gene

miRTarBase miRNAs that target TMED4

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMED4 Gene

Localization for TMED4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMED4 Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMED4 Gene COMPARTMENTS Subcellular localization image for TMED4 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for TMED4 Gene

Pathways & Interactions for TMED4 Gene

SuperPathways for TMED4 Gene

Superpath Contained pathways
1 TNF Signaling (sino)
genes like me logo Genes that share pathways with TMED4: view

Pathways by source for TMED4 Gene

1 Sino Biological pathway for TMED4 Gene

Interacting Proteins for TMED4 Gene

Gene Ontology (GO) - Biological Process for TMED4 Gene

None

No data available for SIGNOR curated interactions for TMED4 Gene

Drugs & Compounds for TMED4 Gene

No Compound Related Data Available

Transcripts for TMED4 Gene

Unigene Clusters for TMED4 Gene

Transmembrane emp24 protein transport domain containing 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMED4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7
SP1: - - -
SP2: - -
SP3: - - - - - -
SP4: - - -
SP5: - - - -
SP6: -
SP7:
SP8:

Relevant External Links for TMED4 Gene

GeneLoc Exon Structure for
TMED4
ECgene alternative splicing isoforms for
TMED4

Expression for TMED4 Gene

mRNA expression in normal human tissues for TMED4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMED4 Gene

This gene is overexpressed in Nasal epithelium (35.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMED4 Gene



SOURCE GeneReport for Unigene cluster for TMED4 Gene Hs.598832

genes like me logo Genes that share expression patterns with TMED4: view

Protein tissue co-expression partners for TMED4 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMED4 Gene

Orthologs for TMED4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TMED4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMED4 35
  • 92.83 (n)
  • 97.5 (a)
TMED4 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMED4 35
  • 90.16 (n)
  • 94.69 (a)
TMED4 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmed4 35
  • 87.37 (n)
  • 94.71 (a)
Tmed4 16
Tmed4 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMED4 35
  • 99.85 (n)
  • 99.56 (a)
TMED4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmed4 35
  • 90.87 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 87 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 66 (a)
ManyToMany
chicken
(Gallus gallus)
Aves LOC100859485 35
  • 83.91 (n)
  • 95.98 (a)
TMED4 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15000 35
tmed4 35
  • 77.11 (n)
  • 92.04 (a)
zebrafish
(Danio rerio)
Actinopterygii tmed4 35
  • 78.44 (n)
  • 89.55 (a)
tmed4 36
  • 81 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003553 35
  • 66.33 (n)
  • 70.85 (a)
fruit fly
(Drosophila melanogaster)
Insecta eca 35
  • 70.83 (n)
  • 72 (a)
eca 36
  • 66 (a)
ManyToMany
p24-2 36
  • 53 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea CELE_Y60A3A.9 35
  • 63.35 (n)
  • 70.15 (a)
T08D2.1 36
  • 52 (a)
ManyToMany
Y60A3A.9 36
  • 67 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL005W 35
  • 45.85 (n)
  • 29.95 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A08778g 35
  • 47.99 (n)
  • 38.22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERP6 35
  • 42.81 (n)
  • 30.46 (a)
ERP1 36
  • 26 (a)
ManyToMany
ERP5 36
  • 26 (a)
ManyToMany
ERP6 36
  • 28 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5270 35
bread mold
(Neurospora crassa)
Ascomycetes NCU04003 35
  • 53.64 (n)
  • 41.62 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC16E9.09c 35
  • 44.84 (n)
  • 32.99 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 66 (a)
OneToMany
Species with no ortholog for TMED4:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMED4 Gene

ENSEMBL:
Gene Tree for TMED4 (if available)
TreeFam:
Gene Tree for TMED4 (if available)

Paralogs for TMED4 Gene

Paralogs for TMED4 Gene

(5) SIMAP similar genes for TMED4 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for TMED4 Gene

genes like me logo Genes that share paralogs with TMED4: view

Variants for TMED4 Gene

Sequence variations from dbSNP and Humsavar for TMED4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1055967 -- 44,578,149(-) TATGG(A/G)AATAC utr-variant-3-prime
rs1055971 -- 44,578,027(-) ACAAA(C/T)TTTAA utr-variant-3-prime
rs1134360 -- 44,578,782(-) TTCAA(A/G)TGATT utr-variant-3-prime
rs1136430 -- 44,580,045(-) CTGAG(G/T)ATAAT intron-variant, utr-variant-3-prime
rs17404280 -- 44,578,828(-) GTGCA(A/G)TGGCG utr-variant-3-prime

Variation tolerance for TMED4 Gene

Residual Variation Intolerance Score: 42.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.84; 17.54% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for TMED4 Gene

Disorders for TMED4 Gene

Relevant External Links for TMED4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMED4

No disorders were found for TMED4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMED4 Gene

Publications for TMED4 Gene

  1. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PMID: 12761501) Matsuda A. … Sugano S. (Oncogene 2003) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3

Products for TMED4 Gene

Sources for TMED4 Gene

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