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Aliases for TMED4 Gene

Aliases for TMED4 Gene

  • Transmembrane Emp24 Protein Transport Domain Containing 4 2 3
  • Putative NF-Kappa-B-Activating Protein 156 3 4
  • P24 Family Protein Alpha-3 3 4
  • P24alpha3 3 4
  • GMP25iso 3 4
  • ERS25 3 4
  • Endoplasmic Reticulum Stress-Response Protein 25 KDa 3
  • Endoplasmic Reticulum Stress-Response Protein 25 4
  • Transmembrane Emp24 Domain-Containing Protein 4 3
  • Putative NFkB Activating Protein HNLF 3
  • HNLF 3

External Ids for TMED4 Gene

Previous GeneCards Identifiers for TMED4 Gene

  • GC07M044391
  • GC07M044584
  • GC07M044503
  • GC07M044617

Summaries for TMED4 Gene

GeneCards Summary for TMED4 Gene

TMED4 (Transmembrane Emp24 Protein Transport Domain Containing 4) is a Protein Coding gene. Among its related pathways are TNF Signaling. GO annotations related to this gene include signal transducer activity. An important paralog of this gene is TMED9.

UniProtKB/Swiss-Prot for TMED4 Gene

  • Involved in vesicular protein trafficking, mainly in the early secretory pathway. targeting. Involved in the maintenance of the Golgi apparatus. Appears to play a role in the biosynthesis of secreted cargo including processing. Involved in endoplasmic reticulum stress response. May play a role in the regulation of heat-shock response and apoptosis (By similarity).

Gene Wiki entry for TMED4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMED4 Gene

Genomics for TMED4 Gene

Regulatory Elements for TMED4 Gene

Genomic Location for TMED4 Gene

Start:
44,577,894 bp from pter
End:
44,582,287 bp from pter
Size:
4,394 bases
Orientation:
Minus strand

Genomic View for TMED4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMED4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMED4 Gene

Proteins for TMED4 Gene

  • Protein details for TMED4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z7H5-TMED4_HUMAN
    Recommended name:
    Transmembrane emp24 domain-containing protein 4
    Protein Accession:
    Q7Z7H5
    Secondary Accessions:
    • A4D2K8
    • B4DFJ4
    • Q56VW3
    • Q7Z432
    • Q8N2P6

    Protein attributes for TMED4 Gene

    Size:
    227 amino acids
    Molecular mass:
    25943 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAP20105.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC77362.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMED4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMED4 Gene

Proteomics data for TMED4 Gene at MOPED

Post-translational modifications for TMED4 Gene

  • Ubiquitination at Lys63, Lys152, and Lys172
  • Glycosylation at Asn117
  • Modification sites at PhosphoSitePlus

Other Protein References for TMED4 Gene

No data available for DME Specific Peptides for TMED4 Gene

Domains for TMED4 Gene

Protein Domains for TMED4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TMED4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z7H5

UniProtKB/Swiss-Prot:

TMED4_HUMAN :
  • Q7Z7H5
Domain:
  • Contains 1 GOLD domain.
Family:
  • Belongs to the EMP24/GP25L family.
genes like me logo Genes that share domains with TMED4: view

No data available for Gene Families for TMED4 Gene

Function for TMED4 Gene

Molecular function for TMED4 Gene

UniProtKB/Swiss-Prot Function: Involved in vesicular protein trafficking, mainly in the early secretory pathway. targeting. Involved in the maintenance of the Golgi apparatus. Appears to play a role in the biosynthesis of secreted cargo including processing. Involved in endoplasmic reticulum stress response. May play a role in the regulation of heat-shock response and apoptosis (By similarity).

Gene Ontology (GO) - Molecular Function for TMED4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IMP 12761501
genes like me logo Genes that share ontologies with TMED4: view

Phenotypes for TMED4 Gene

genes like me logo Genes that share phenotypes with TMED4: view

miRNA for TMED4 Gene

miRTarBase miRNAs that target TMED4

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMED4 Gene

Localization for TMED4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMED4 Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMED4 Gene COMPARTMENTS Subcellular localization image for TMED4 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TMED4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with TMED4: view

Pathways for TMED4 Gene

SuperPathways for TMED4 Gene

Superpath Contained pathways
1 TNF Signaling
genes like me logo Genes that share pathways with TMED4: view

Pathways by source for TMED4 Gene

1 Sino Biological pathway for TMED4 Gene

Interacting Proteins for TMED4 Gene

Gene Ontology (GO) - Biological Process for TMED4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0007165 signal transduction IMP 12761501
GO:0015031 protein transport IEA --
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP 12761501
genes like me logo Genes that share ontologies with TMED4: view

Transcripts for TMED4 Gene

Unigene Clusters for TMED4 Gene

Transmembrane emp24 protein transport domain containing 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMED4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7
SP1: - - -
SP2: - -
SP3: - - - - - -
SP4: - - -
SP5: - - - -
SP6: -
SP7:
SP8:

Relevant External Links for TMED4 Gene

GeneLoc Exon Structure for
TMED4
ECgene alternative splicing isoforms for
TMED4

Expression for TMED4 Gene

mRNA expression in normal human tissues for TMED4 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMED4 Gene

SOURCE GeneReport for Unigene cluster for TMED4 Gene Hs.598832

genes like me logo Genes that share expressions with TMED4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMED4 Gene

Orthologs for TMED4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TMED4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMED4 35
  • 99.85 (n)
  • 99.56 (a)
TMED4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMED4 35
  • 92.83 (n)
  • 97.5 (a)
TMED4 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMED4 35
  • 90.16 (n)
  • 94.69 (a)
TMED4 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmed4 35
  • 87.37 (n)
  • 94.71 (a)
Tmed4 16
Tmed4 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 87 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 66 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Tmed4 35
  • 90.87 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves LOC100859485 35
  • 83.91 (n)
  • 95.98 (a)
TMED4 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15000 35
tmed4 35
  • 77.11 (n)
  • 92.04 (a)
zebrafish
(Danio rerio)
Actinopterygii tmed4 35
  • 78.44 (n)
  • 89.55 (a)
tmed4 36
  • 81 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003553 35
  • 66.33 (n)
  • 70.85 (a)
fruit fly
(Drosophila melanogaster)
Insecta eca 35
  • 70.83 (n)
  • 72 (a)
eca 36
  • 66 (a)
ManyToMany
p24-2 36
  • 53 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea CELE_Y60A3A.9 35
  • 63.35 (n)
  • 70.15 (a)
T08D2.1 36
  • 52 (a)
ManyToMany
Y60A3A.9 36
  • 67 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL005W 35
  • 45.85 (n)
  • 29.95 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERP1 36
  • 26 (a)
ManyToMany
ERP5 36
  • 26 (a)
ManyToMany
ERP6 35
  • 42.81 (n)
  • 30.46 (a)
ERP6 36
  • 28 (a)
ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A08778g 35
  • 47.99 (n)
  • 38.22 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04003 35
  • 53.64 (n)
  • 41.62 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC16E9.09c 35
  • 44.84 (n)
  • 32.99 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5270 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 66 (a)
OneToMany
Species with no ortholog for TMED4:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMED4 Gene

ENSEMBL:
Gene Tree for TMED4 (if available)
TreeFam:
Gene Tree for TMED4 (if available)

Paralogs for TMED4 Gene

Paralogs for TMED4 Gene

Selected SIMAP similar genes for TMED4 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for TMED4 Gene

genes like me logo Genes that share paralogs with TMED4: view

Variants for TMED4 Gene

Sequence variations from dbSNP and Humsavar for TMED4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs217360 -- 44,580,763(-) ctcca(C/T)gttgg intron-variant
rs217361 -- 44,579,703(-) GAGTA(A/G)TTACA intron-variant
rs217362 -- 44,579,000(-) TTCTA(A/T)ATCTT downstream-variant-500B
rs217363 -- 44,578,849(-) gctct(C/T)gtcgc downstream-variant-500B
rs1136430 -- 44,580,045(-) CTGAG(G/T)ATAAT intron-variant

Relevant External Links for TMED4 Gene

HapMap Linkage Disequilibrium report
TMED4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMED4 Gene

Disorders for TMED4 Gene

No disorders were found for TMED4 Gene.

No data available for UniProtKB/Swiss-Prot for TMED4 Gene

Publications for TMED4 Gene

  1. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PMID: 12761501) Matsuda A. … Sugano S. (Oncogene 2003) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  4. Novel oxidative stress-responsive gene ERS25 functions as a regulator of the heat-shock and cell death response. (PMID: 18326488) Hwang S.O. … Lee S.W. (J. Biol. Chem. 2008) 3 4
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for TMED4 Gene

  • Addgene plasmids for TMED4

Sources for TMED4 Gene

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