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Aliases for TMED4 Gene

Aliases for TMED4 Gene

  • Transmembrane P24 Trafficking Protein 4 2 3 5
  • Transmembrane Emp24 Protein Transport Domain Containing 4 2 3
  • Putative NF-Kappa-B-Activating Protein 156 3 4
  • P24 Family Protein Alpha-3 3 4
  • P24alpha3 3 4
  • GMP25iso 3 4
  • ERS25 3 4
  • Endoplasmic Reticulum Stress-Response Protein 25 KDa 3
  • Endoplasmic Reticulum Stress-Response Protein 25 4
  • Transmembrane Emp24 Domain-Containing Protein 4 3
  • Putative NFkB Activating Protein HNLF 3
  • P24a3 3
  • HNLF 3

External Ids for TMED4 Gene

Previous GeneCards Identifiers for TMED4 Gene

  • GC07M044391
  • GC07M044584
  • GC07M044503
  • GC07M044617

Summaries for TMED4 Gene

GeneCards Summary for TMED4 Gene

TMED4 (Transmembrane P24 Trafficking Protein 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include signal transducer activity. An important paralog of this gene is TMED9.

UniProtKB/Swiss-Prot for TMED4 Gene

  • Involved in vesicular protein trafficking, mainly in the early secretory pathway. targeting. Involved in the maintenance of the Golgi apparatus. Appears to play a role in the biosynthesis of secreted cargo including processing. Involved in endoplasmic reticulum stress response. May play a role in the regulation of heat-shock response and apoptosis (By similarity).

Gene Wiki entry for TMED4 Gene

Additional gene information for TMED4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMED4 Gene

Genomics for TMED4 Gene

GeneHancer (GH) Regulatory Elements for TMED4 Gene

Promoters and enhancers for TMED4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I044580 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 550.8 +0.4 357 3.2 HDGF SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF207 ZNF143 GC07P044582 GC07P044583 PIR31244 PIR35616 TMED4 DDX56 SNORA5C ENSG00000228434 SPDYE1 SNHG15
GH07I044121 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 32.9 +459.3 459255 3.4 HDGF PKNOX1 CLOCK MLX ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF213 POLD2 POLM TMED4 SPDYE1 SNORA5B ENSG00000228434 DDX56 SNORA5C TBRG4 TUBG1P
GH07I044845 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 22.4 -265.3 -265289 4.2 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC GLIS1 H2AFV LINC01952 CICP20 DDX56 SNORA5C POLM SNORA5B ENSG00000228434 SPDYE1 TMED4
GH07I044488 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12.5 +92.0 92004 2.6 CLOCK ZFP64 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC MEF2D NUDCD3 DDX56 TMED4 URGCP SNORA5B SNORA5C PURB GC07M044472 GC07M044473
GH07I044983 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 14.8 -403.3 -403344 5.2 HDGF PKNOX1 SMAD1 ARNT SIN3A ZNF2 IRF4 YY1 POLR2B ZNF766 SNHG15 SNORA9 GC07M044985 DDX56 CCM2 POLM SNORA5C ENSG00000260997 TMED4 SNORA5A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMED4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMED4 gene promoter:

Genomic Locations for TMED4 Gene

Genomic Locations for TMED4 Gene
chr7:44,577,894-44,582,295
(GRCh38/hg38)
Size:
4,402 bases
Orientation:
Minus strand
chr7:44,617,493-44,621,886
(GRCh37/hg19)

Genomic View for TMED4 Gene

Genes around TMED4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMED4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMED4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMED4 Gene

Proteins for TMED4 Gene

  • Protein details for TMED4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z7H5-TMED4_HUMAN
    Recommended name:
    Transmembrane emp24 domain-containing protein 4
    Protein Accession:
    Q7Z7H5
    Secondary Accessions:
    • A4D2K8
    • B4DFJ4
    • Q56VW3
    • Q7Z432
    • Q8N2P6

    Protein attributes for TMED4 Gene

    Size:
    227 amino acids
    Molecular mass:
    25943 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAP20105.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC77362.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMED4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMED4 Gene

Post-translational modifications for TMED4 Gene

  • Ubiquitination at isoforms=363, posLast=152152, and posLast=172172
  • Glycosylation at isoforms=2, 3117

Other Protein References for TMED4 Gene

No data available for DME Specific Peptides for TMED4 Gene

Domains & Families for TMED4 Gene

Gene Families for TMED4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for TMED4 Gene

Suggested Antigen Peptide Sequences for TMED4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z7H5

UniProtKB/Swiss-Prot:

TMED4_HUMAN :
  • Belongs to the EMP24/GP25L family.
Family:
  • Belongs to the EMP24/GP25L family.
genes like me logo Genes that share domains with TMED4: view

Function for TMED4 Gene

Molecular function for TMED4 Gene

UniProtKB/Swiss-Prot Function:
Involved in vesicular protein trafficking, mainly in the early secretory pathway. targeting. Involved in the maintenance of the Golgi apparatus. Appears to play a role in the biosynthesis of secreted cargo including processing. Involved in endoplasmic reticulum stress response. May play a role in the regulation of heat-shock response and apoptosis (By similarity).

Phenotypes From GWAS Catalog for TMED4 Gene

Gene Ontology (GO) - Molecular Function for TMED4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity HMP 12761501
genes like me logo Genes that share ontologies with TMED4: view
genes like me logo Genes that share phenotypes with TMED4: view

miRNA for TMED4 Gene

miRTarBase miRNAs that target TMED4

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMED4 Gene

Localization for TMED4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMED4 Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMED4 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
plasma membrane 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMED4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA,HDA 23376485
genes like me logo Genes that share ontologies with TMED4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMED4 Gene

Pathways & Interactions for TMED4 Gene

SuperPathways for TMED4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMED4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0007165 signal transduction IEA --
GO:0015031 protein transport IEA --
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP,HMP 12761501
genes like me logo Genes that share ontologies with TMED4: view

No data available for Pathways by source and SIGNOR curated interactions for TMED4 Gene

Drugs & Compounds for TMED4 Gene

No Compound Related Data Available

Transcripts for TMED4 Gene

Unigene Clusters for TMED4 Gene

Transmembrane emp24 protein transport domain containing 4:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMED4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7
SP1: - - -
SP2: - -
SP3: - - - - - -
SP4: - - -
SP5: - - - -
SP6: -
SP7:
SP8:

Relevant External Links for TMED4 Gene

GeneLoc Exon Structure for
TMED4
ECgene alternative splicing isoforms for
TMED4

Expression for TMED4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMED4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMED4 Gene

This gene is overexpressed in Nasal epithelium (35.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMED4 Gene



Protein tissue co-expression partners for TMED4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMED4 Gene:

TMED4

SOURCE GeneReport for Unigene cluster for TMED4 Gene:

Hs.598832

Evidence on tissue expression from TISSUES for TMED4 Gene

  • Nervous system(4.9)
  • Lung(4.8)
  • Pancreas(4.7)
  • Liver(4.6)
  • Intestine(3.6)
  • Skin(3.2)
  • Kidney(3)
  • Eye(2.9)
  • Stomach(2.7)
genes like me logo Genes that share expression patterns with TMED4: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMED4 Gene

Orthologs for TMED4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TMED4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMED4 33 34
  • 99.85 (n)
cow
(Bos Taurus)
Mammalia TMED4 33 34
  • 92.83 (n)
rat
(Rattus norvegicus)
Mammalia Tmed4 33
  • 90.87 (n)
dog
(Canis familiaris)
Mammalia TMED4 33 34
  • 90.16 (n)
mouse
(Mus musculus)
Mammalia Tmed4 33 16 34
  • 87.37 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 87 (a)
OneToMany
-- 34
  • 82 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 66 (a)
ManyToMany
chicken
(Gallus gallus)
Aves TMED4 34
  • 84 (a)
OneToOne
LOC100859485 33
  • 83.91 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmed4 33
  • 77.11 (n)
Str.15000 33
zebrafish
(Danio rerio)
Actinopterygii tmed4 33 34
  • 78.44 (n)
fruit fly
(Drosophila melanogaster)
Insecta eca 33 34
  • 70.83 (n)
p24-2 34
  • 53 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003553 33
  • 66.33 (n)
worm
(Caenorhabditis elegans)
Secernentea Y60A3A.9 34
  • 67 (a)
ManyToMany
CELE_Y60A3A.9 33
  • 63.35 (n)
T08D2.1 34
  • 52 (a)
ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A08778g 33
  • 47.99 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL005W 33
  • 45.85 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERP6 33 34
  • 42.81 (n)
ERP1 34
  • 26 (a)
ManyToMany
ERP5 34
  • 26 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 66 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU04003 33
  • 53.64 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC16E9.09c 33
  • 44.84 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5270 33
Species where no ortholog for TMED4 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMED4 Gene

ENSEMBL:
Gene Tree for TMED4 (if available)
TreeFam:
Gene Tree for TMED4 (if available)

Paralogs for TMED4 Gene

Paralogs for TMED4 Gene

(5) SIMAP similar genes for TMED4 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for TMED4 Gene

genes like me logo Genes that share paralogs with TMED4: view

Variants for TMED4 Gene

Sequence variations from dbSNP and Humsavar for TMED4 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000017430 -- 44,583,714(-) A/G upstream_transcript_variant
rs1000063199 -- 44,584,130(-) C/T upstream_transcript_variant
rs1000161456 -- 44,583,226(-) T/C upstream_transcript_variant
rs1000359756 -- 44,577,813(-) A/G downstream_transcript_variant
rs1001407164 -- 44,577,424(-) C/A downstream_transcript_variant

Variation tolerance for TMED4 Gene

Residual Variation Intolerance Score: 42.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.84; 17.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMED4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMED4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMED4 Gene

Disorders for TMED4 Gene

Additional Disease Information for TMED4

No disorders were found for TMED4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMED4 Gene

Publications for TMED4 Gene

  1. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PMID: 12761501) Matsuda A … Sugano S (Oncogene 2003) 2 3 4 58
  2. Novel oxidative stress-responsive gene ERS25 functions as a regulator of the heat-shock and cell death response. (PMID: 18326488) Hwang SO … Lee SW (The Journal of biological chemistry 2008) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for TMED4 Gene

  • Addgene plasmids for TMED4

Sources for TMED4 Gene

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