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TMED4 Gene

protein-coding   GIFtS: 50
GCID: GC07M044617

Transmembrane Emp24 Protein Transport Domain Containing...

  Search for TMED4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Emp24 Protein Transport Domain Containing 41 2     HNLF2
Putative NF-Kappa-B-Activating Protein 1562 3     Endoplasmic Reticulum Stress-Response Protein 25 KDa2
ERS252 3     Putative NFkB Activating Protein HNLF2
GMP25iso2 3     Transmembrane Emp24 Domain-Containing Protein 42
P24 Family Protein Alpha-32 3     Endoplasmic Reticulum Stress-Response Protein 253
p24alpha32 3     

External Ids:    HGNC: 223011   Entrez Gene: 2220682   Ensembl: ENSG000001586047   OMIM: 6120385   UniProtKB: Q7Z7H53   

Export aliases for TMED4 gene to outside databases

Previous GC identifers: GC07M044391 GC07M044584 GC07M044503


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMED4 Gene:
TMED4 (transmembrane emp24 protein transport domain containing 4) is a protein-coding gene. GO annotations related to this gene include signal transducer activity. An important paralog of this gene is TMED9.

UniProtKB/Swiss-Prot: TMED4_HUMAN, Q7Z7H5
Function: Involved in vesicular protein trafficking, mainly in the early secretory pathway. targeting. Involved in
the maintenance of the Golgi apparatus. Appears to play a role in the biosynthesis of secreted cargo including
processing. Involved in endoplasmic reticulum stress response. May play a role in the regulation of heat-shock
response and apoptosis (By similarity)

Gene Wiki entry for TMED4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007819.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMED4 gene promoter:
         GR   AML1a   AP-1   MyoD   Nkx2-5   Tal-1beta   GATA-1   GR-alpha   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMED4 promoter sequence
   Search Chromatin IP Primers for TMED4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMED4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p13   Ensembl cytogenetic band:  7p13   HGNC cytogenetic band: 7p13

TMED4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMED4 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M044617:  view genomic region     (about GC identifiers)

Start:
44,617,493 bp from pter      End:
44,621,886 bp from pter
Size:
4,394 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 44,658,279-44,661,344     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TMED4_HUMAN, Q7Z7H5 (See protein sequence)
Recommended Name: Transmembrane emp24 domain-containing protein 4 precursor  
Size: 227 amino acids; 25943 Da
Sequence caution: Sequence=AAP20105.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAC77362.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A4D2K8 B4DFJ4 Q56VW3 Q7Z432 Q8N2P6
Alternative splicing: 3 isoforms:  Q7Z7H5-1   Q7Z7H5-2   Q7Z7H5-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TMED4: NX_Q7Z7H5

Explore proteomics data for TMED4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys63, Lys152, Lys172
  • Glycosylation2 at Asn117
  • Modification sites at PhosphoSitePlus

  • See TMED4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_872353.2  
    ENSEMBL proteins: 
     ENSP00000404042   ENSP00000289577   ENSP00000417443  

    TMED4 Human Recombinant Protein Products:

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    Sino Biological Cell Lysate for TMED4
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    Cloud-Clone Corp. Proteins for TMED4

     
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    TMED4 Antibody Products:

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    Search eBioscience for ELISAs for TMED4 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR009038 GOLD

    Graphical View of Domain Structure for InterPro Entry Q7Z7H5

    ProtoNet protein and cluster: Q7Z7H5

    1 Blocks protein domain: IPB000348 emp24/gp25L/p24 family

    UniProtKB/Swiss-Prot: TMED4_HUMAN, Q7Z7H5
    Similarity: Belongs to the EMP24/GP25L family
    Similarity: Contains 1 GOLD domain


    Find genes that share domains with TMED4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TMED4_HUMAN, Q7Z7H5
    Function: Involved in vesicular protein trafficking, mainly in the early secretory pathway. targeting. Involved in
    the maintenance of the Golgi apparatus. Appears to play a role in the biosynthesis of secreted cargo including
    processing. Involved in endoplasmic reticulum stress response. May play a role in the regulation of heat-shock
    response and apoptosis (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity IMP12761501
         
    Find genes that share ontologies with TMED4           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for TMED4:
     Decreased viability of wild-ty  Large nuclei 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMED4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMED4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMED4

    miRNA
    Products:
        
    miRTarBase miRNAs that target TMED4:
    hsa-let-7d-5p (MIRT032125), hsa-mir-100-5p (MIRT048520), hsa-mir-181a-5p (MIRT025119)

    Block miRNA regulation of human, mouse, rat TMED4 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate TMED4:
    hsa-miR-579 hsa-miR-3153
    SwitchGear 3'UTR luciferase reporter plasmidTMED4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TMED4

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    GenScript: all cDNA clones in your preferred vector: TMED4 (NM_182547)
    Sino Biological Human cDNA Clone for TMED4
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMED4

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMED4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TMED4_HUMAN, Q7Z7H5: Endoplasmic reticulum membrane; Single-pass type I membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    extracellular1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TMED4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TMED4 About    
    See pathways by source

    SuperPathContained pathways About
    1TNF Signaling
    NF-kB (NFkB) Pathway0.46


    1 Sino Biological Pathway for TMED4
        NF-kB (NFkB) Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMED4
    Interactions:

        Search GeneGlobe Interaction Network for TMED4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TMED4 (ENSP000004040424) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KIAA0368ENSP000002593354STRING: ENSP00000259335
    CNIH4ENSP000004204434STRING: ENSP00000420443
    PIGBENSP000001643054STRING: ENSP00000164305
    NDUFAB1ENSP000000075164STRING: ENSP00000007516
    TMED5ENSP000003593054STRING: ENSP00000359305
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0007165signal transduction IMP12761501
    GO:0015031protein transport IEA--
    GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling IMP12761501

    Find genes that share ontologies with TMED4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMED4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TMED4 gene: 
    NM_182547.2  

    Unigene Cluster for TMED4:

    Transmembrane emp24 protein transport domain containing 4
    Hs.598832  [show with all ESTs]
    Unigene Representative Sequence: BC035467
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000457408(uc003tli.3) ENST00000289577 ENST00000481238(uc003tlk.3)
    ENST00000477639(uc003tlj.3) ENST00000444131
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TMED4 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate TMED4:
    hsa-miR-579 hsa-miR-3153
    SwitchGear 3'UTR luciferase reporter plasmidTMED4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TMED4
    Predesigned siRNA for gene silencing in human, mouse, rat TMED4
    Clone
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    OriGene clones in human, mouse for TMED4 (see all 7)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TMED4 (NM_182547)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMED4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMED4
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TMED4
    OriGene qSTAR qPCR primer pairs in human, mouse for TMED4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMED4
      QuantiTect SYBR Green Assays in human, mouse, rat TMED4
      QuantiFast Probe-based Assays in human, mouse, rat TMED4

    Additional mRNA sequence: 

    AB097009.1 AK074557.1 AK290125.1 AK294122.1 AY191223.1 BC035467.1 BC052641.1 BC053583.1 
    BC057851.1 BX647965.1 

    22 DOTS entries:

    DT.100886960  DT.448262  DT.101984218  DT.92452919  DT.92452912  DT.92452918  DT.100038316  DT.121116475 
    DT.100886972  DT.121116551  DT.121116474  DT.100886967  DT.101980997  DT.99989216  DT.100717477  DT.121116470 
    DT.121116542  DT.95364253  DT.92066887  DT.95364243  DT.95364249  DT.95364252 

    Selected AceView cDNA sequences (see all 854):

    CR620751 BM550692 BU730477 NM_019082 CA419945 CR618912 CF242928 BM829750 
    BQ613890 BE551175 AI708361 H21883 AA234481 BM555824 BQ879215 BM559418 
    CB146543 BM704217 Z42336 CA416263 AI184019 BP872868 CB107676 BU074198 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TMED4 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7
    SP1:                    -                                   -     -                     
    SP2:                    -                                   -                           
    SP3:              -     -                                   -     -     -     -         
    SP4:              -     -     -                                                         
    SP5:                    -                             -     -     -                     


    ECgene alternative splicing isoforms for TMED4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMED4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TMED4 Expression
    About this image

    TMED4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMED4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.598832
        Custom PCR Arrays for TMED4
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    QuantiFast Probe-based Assays in human, mouse, rat TMED4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMED4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TMED4 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmed41 , 5 transmembrane emp24 protein transport domain containing more1, 5 87.37(n)1
    94.71(a)1
      11 (3.94 cM)5
    1036941  NM_134020.11  NP_598781.11 
     62703695 
    chicken
    (Gallus gallus)
    Aves LOC1008594851 transmembrane emp24 domain-containing protein 4-like 83.91(n)
    95.98(a)
      100859485  XM_003643526.1  XP_003643574.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia CA971665.12   -- 78.29(n)    CA971665.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tmed41 transmembrane emp24 protein transport domain containing more 78.44(n)
    89.55(a)
      415224  NM_001002134.1  NP_001002134.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta eca1 eclair 70.83(n)
    72(a)
      41177  NM_176439.3  NP_788616.1 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_Y60A3A.91 CELE_Y60A3A.9 63.35(n)
    70.15(a)
      180307  NM_075460.3  NP_507861.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ERP61 ERP6 42.81(n)
    30.46(a)
      852882   NP_011513.1 


    ENSEMBL Gene Tree for TMED4 (if available)
    TreeFam Gene Tree for TMED4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TMED4 gene
    TMED92  
    5 SIMAP similar genes for TMED4 using alignment to 2 protein entries:     TMED4_HUMAN (see all proteins):
    TMED9    TMED10    TMED7    RNP24    TMED2

    Find genes that share paralogs with TMED4           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for TMED4
    PGOHUM00000250690


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMED4 (see all 139)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1848492141,2
    --44593768(+) TGAGCA/GTGGTG 1 -- int10--------
    rs1866110991,2
    --44593804(+) CAGGAA/GACTGA 1 -- int10--------
    rs174042801,2
    F--44593869(-) GTGCAA/GTGGCG 1 -- int11Minor allele frequency- G:0.32MN 184
    rs2173631,2
    C,F,A,H--44593890(-) gctctC/Tgtcgc 1 -- int1 ese37Minor allele frequency- T:0.29NA WA 14
    rs1385651431,2
    C--44593926(+) AAAAA-/A/GGGAAA 1 -- int10--------
    rs570052101,2
    C--44593927(+) AAAAGA/-GAAAA 1 -- int11Minor allele frequency- -:0.00NA 2
    rs1922083111,2
    --44593977(+) CTAGTC/TACAGG 1 -- int10--------
    rs2173621,2
    C,F,O,A,H--44594041(-) TTCTAT/AATCTT 1 -- int1 ese319Minor allele frequency- A:0.20MN NS EA NA WA CSA 1088
    rs1845343231,2
    C--44594062(+) ATCCTC/TTAGGG 1 -- int10--------
    rs47243121,2
    C,F,H--44594112(+) GTGAAC/GCCAGA 1 -- int1 ese326Minor allele frequency- G:0.14EA NA NS WA 2978

    HapMap Linkage Disequilibrium report for TMED4 (44617493 - 44621886 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TMED4: --
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing TMED4
    DNA2.0 Custom Variant and Variant Library Synthesis for TMED4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612038    OMIM disorders: --


    Find genes that share disorders with TMED4           About GenesLikeMe


    Export disorders for TMED4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMED4 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with TMED4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PubMed id 12761501)1, 2, 3 Matsuda A....Sugano S. (Oncogene 2003)
    2. Novel oxidative stress-responsive gene ERS25 functions as a regulator of the heat-shock and cell death response. (PubMed id 18326488)1, 2 Hwang S.O.... Lee S.W. (J. Biol. Chem. 2008)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    8. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 JAoger S....Krogan N.J. (Nature 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 222068 HGNC: 22301 AceView: DDX56andHNLF Ensembl:ENSG00000158604 euGenes: HUgn222068
    ECgene: TMED4 H-InvDB: TMED4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TMED4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMED4 gene:
    Search GeneIP for patents involving TMED4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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