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TMED3 Gene

protein-coding   GIFtS: 50
GCID: GC15P079603

Transmembrane Emp24 Protein Transport Domain Containing...

(Previous names: chromosome 15 open reading frame 22, transmembrane emp24...)
(Previous symbol: C15orf22)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Emp24 Protein Transport Domain Containing 31 2     p262 3
C15orf221 2 3     Chromosome 15 Open Reading Frame 221
Transmembrane Emp24 Domain Containing 31 2     P24B2
Membrane Protein P24B2 3     Integral Type I Protein2
P24 Family Protein Gamma-42 3     Transmembrane Emp24 Domain-Containing Protein 32
p24gamma42 3     

External Ids:    HGNC: 288891   Entrez Gene: 234232   Ensembl: ENSG000001665577   UniProtKB: Q9Y3Q33   

Export aliases for TMED3 gene to outside databases

Previous GC identifers: GC15P077391 GC15P056361


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMED3 Gene:
TMED3 (transmembrane emp24 protein transport domain containing 3) is a protein-coding gene. Diseases associated with TMED3 include keratoconus, and pulmonary function. An important paralog of this gene is TMED5.

UniProtKB/Swiss-Prot: TMED3_HUMAN, Q9Y3Q3
Function: Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Contributes to
the coupled localization of TMED2 and TMED10 in the cis-Golgi network




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMED3 gene promoter:
         Max1   AML1a   SREBP-1c   MIF-1   SREBP-1b   AREB6   SREBP-1a   Chx10   Zic3   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMED3 promoter sequence
   Search Chromatin IP Primers for TMED3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMED3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24-q25   Ensembl cytogenetic band:  15q25.1   HGNC cytogenetic band: 15q24-q25

TMED3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMED3 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P079603:  view genomic region     (about GC identifiers)

Start:
79,603,404 bp from pter      End:
79,704,334 bp from pter
Size:
100,931 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TMED3_HUMAN, Q9Y3Q3 (See protein sequence)
Recommended Name: Transmembrane emp24 domain-containing protein 3 precursor  
Size: 217 amino acids; 24777 Da
Subunit: Monomer in endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment and cis-Golgi
network. Interacts (via C-terminus) with COPG1; the interaction involves dimeric TMED3; however, there are
conflicting reports on the interaction. Interacts with GORASP1 and GORASP2 (By similarity)
Secondary accessions: A8K069 B4DN05 Q2T9F8
Alternative splicing: 2 isoforms:  Q9Y3Q3-1   Q9Y3Q3-2   

Explore the universe of human proteins at neXtProt for TMED3: NX_Q9Y3Q3

Explore proteomics data for TMED3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TMED3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_031390.1  
    ENSEMBL proteins: 
     ENSP00000299705   ENSP00000414983   ENSP00000446062   ENSP00000440228  

    TMED3 Human Recombinant Protein Products:

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    Novus Biologicals TMED3 Protein
    Novus Biologicals TMED3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for TMED3

    TMED3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for TMED3
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    LSBio Antibodies in human, mouse, rat for TMED3

    TMED3 Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TMED3
    Cloud-Clone Corp. CLIAs for TMED3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR015718 P24-related
     IPR009038 GOLD

    Graphical View of Domain Structure for InterPro Entry Q9Y3Q3

    ProtoNet protein and cluster: Q9Y3Q3

    1 Blocks protein domain: IPB000348 emp24/gp25L/p24 family

    UniProtKB/Swiss-Prot: TMED3_HUMAN, Q9Y3Q3
    Similarity: Belongs to the EMP24/GP25L family
    Similarity: Contains 1 GOLD domain


    TMED3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TMED3_HUMAN, Q9Y3Q3
    Function: Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Contributes to
    the coupled localization of TMED2 and TMED10 in the cis-Golgi network

    Phenotypes:
         2 GenomeRNAi human phenotypes for TMED3:

     Decreased POU5F1-GFP protein e  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMED3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TMED3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMED3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMED3

    miRNA
    Products:
        
    miRTarBase miRNAs that target TMED3:
    hsa-mir-30a-5p (MIRT005140)

    Block miRNA regulation of human, mouse, rat TMED3 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate TMED3:
    hsa-miR-661
    SwitchGear 3'UTR luciferase reporter plasmidTMED3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TMED3
    Predesigned siRNA for gene silencing in human, mouse, rat TMED3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TMED3

    Clone
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    OriGene clones in human, mouse for TMED3 (see all 7)
    OriGene ORF clones in mouse, rat for TMED3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TMED3 (NM_007364)
    Sino Biological Human cDNA Clone for TMED3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMED3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMED3

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for TMED3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMED3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TMED3_HUMAN, Q9Y3Q3: Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane
    protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Golgi apparatus, Golgi
    stack membrane; Single-pass type I membrane protein (By similarity). Endoplasmic reticulum membrane; Single-pass
    type I membrane protein. Cytoplasmic vesicle, COPI-coated vesicle membrane; Single-pass type I membrane protein
    (By similarity). Note=Probably cycles between compartments of the early secretatory pathway
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    golgi apparatus5
    mitochondrion2
    extracellular1
    lysosome1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA12237308
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005793endoplasmic reticulum-Golgi intermediate compartment IDA12237308
    GO:0005794Golgi apparatus IDA12237308
    GO:0016021integral component of membrane IEA--

    TMED3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMED3
    Interactions:

        Search GeneGlobe Interaction Network for TMED3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TMED3 (Q9Y3Q33 ENSP000002997054) via UniProtKB, MINT, STRING, and/or I2D (see all 61)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GORASP1Q9BQQ33, ENSP000003138694I2D: score=1 STRING: ENSP00000313869
    GORASP2Q9H8Y83, ENSP000002341604I2D: score=1 STRING: ENSP00000234160
    AFTPHENSP000002388554STRING: ENSP00000238855
    AP1G2ENSP000003124424STRING: ENSP00000312442
    AP1S1ENSP000003366664STRING: ENSP00000336666
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0015031protein transport IEA--

    TMED3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMED3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TMED3 gene: 
    NM_007364.2  

    Unigene Cluster for TMED3:

    Transmembrane emp24 protein transport domain containing 3
    Hs.513058  [show with all ESTs]
    Unigene Representative Sequence: AK075529
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000299705(uc002beu.3) ENST00000424155(uc010unj.1) ENST00000536821
    ENST00000543455(uc002bev.3) ENST00000558562
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TMED3 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate TMED3:
    hsa-miR-661
    SwitchGear 3'UTR luciferase reporter plasmidTMED3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TMED3
    Predesigned siRNA for gene silencing in human, mouse, rat TMED3
    Clone
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    OriGene clones in human, mouse for TMED3 (see all 7)
    OriGene ORF clones in mouse, rat for TMED3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TMED3 (NM_007364)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMED3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMED3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TMED3
    OriGene qSTAR qPCR primer pairs in human, mouse for TMED3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMED3
      QuantiTect SYBR Green Assays in human, mouse, rat TMED3
      QuantiFast Probe-based Assays in human, mouse, rat TMED3

    Additional mRNA sequence: 

    AJ132270.1 AK075529.1 AK222516.1 AK289434.1 AK297710.1 AK304148.1 AL109672.1 AL109673.1 
    AY358974.1 BC000027.2 BC010853.1 BC017495.1 BC022232.1 BC111547.1 CR457384.1 

    10 DOTS entries:

    DT.453957  DT.92042517  DT.100845434  DT.100845435  DT.95260376  DT.95260384  DT.100030424  DT.95260380 
    DT.121062933  DT.91758419 

    Selected AceView cDNA sequences (see all 505):

    BM974584 AW152403 CR608578 BI253912 CA309007 BM699123 CR621451 BM875445 
    BQ897684 CR591443 CR608143 CR605050 BM669780 CA422319 BM549126 BM852006 
    BQ006818 AI679582 BM990265 CA412038 CF541301 BM992648 BQ045230 AI922870 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TMED3    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d
    SP1:                    -     -                 -                           
    SP2:                                            -                           
    SP3:                                      -     -                           
    SP4:                                                                        


    ECgene alternative splicing isoforms for TMED3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMED3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAGCAGGAC
    TMED3 Expression
    About this image


    TMED3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Endochondral Facial Bones
     
     Cartilage (Muscoskeletal System)
             Meckel's Cartilage
     
     Colon (Gastrointestinal Tract)
     
     Thyroid (Endocrine System)
     
     Pancreas (Endocrine System)
    TMED3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMED3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.513058
        Custom PCR Arrays for TMED3
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TMED3
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    QuantiFast Probe-based Assays in human, mouse, rat TMED3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMED3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TMED3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmed31 , 5 transmembrane emp24 domain containing 31, 5 87.54(n)1
    93.94(a)1
      9 (47.24 cM)5
    661111  NM_025360.21  NP_079636.21 
     896992035 
    chicken
    (Gallus gallus)
    Aves TMED31 transmembrane emp24 protein transport domain containing more 78.35(n)
    80.93(a)
      415580  XM_413948.4  XP_413948.3 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb09b112 Danio rerio cDNA clone IMAGE6792672, partial cds 74.33(n)    BC056540.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta p24-16
    p24-related-1
    44(a)
    1 → many
    X(11745364-11746548)
    worm
    (Caenorhabditis elegans)
    Secernentea F57B10.56
    Protein F57B10.5 (F57B10.5) mRNA, complete cds
    50(a)
    1 → many
    I(6562699-6563660) WBGene00019003
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes EMP246
    Component of the p24 complex; binds to GPI anchor ...
    22(a)
    1 → many
    VII(122694-123305) YGL200C


    ENSEMBL Gene Tree for TMED3 (if available)
    TreeFam Gene Tree for TMED3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TMED3 gene
    TMED52  TICAM22  TMED12  TMED7-TICAM22  TMED22  TMED72  
    4 SIMAP similar genes for TMED3 using alignment to 4 protein entries:     TMED3_HUMAN (see all proteins):
    TMED7    TMED2    TMED5    RNP24

    TMED3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMED3 (see all 370)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs354421711,2
    C,F--56359742(+) GAGCTA/TCTTCA 1 -- us2k112Minor allele frequency- T:0.39NA WA CSA EA 376
    rs1461925281,2
    --56359986(+) GCCTGA/GTTAAT 1 -- us2k10--------
    rs1892572971,2
    --56360020(+) AACGAG/TGTTTC 1 -- us2k10--------
    rs284149671,2
    C,F--56360029(+) TCACTA/CTGTTG 1 -- us2k11Minor allele frequency- C:0.11WA 118
    rs1806789011,2
    --56360048(+) AGATTC/TGAACT 1 -- us2k10--------
    rs1847377691,2
    --56360145(+) TTGTTA/CGTCTT 1 -- us2k10--------
    rs1892933471,2
    --56360423(+) CCCGCC/TTCAGC 1 -- us2k10--------
    rs1180986091,2
    C,F--56360670(+) ACTATG/ATTATG 1 -- us2k11Minor allele frequency- A:0.02EA 120
    rs1817111781,2
    --56360677(+) TATGCA/GTGCAT 1 -- us2k10--------
    rs1857822541,2
    --56360731(+) CATCCA/GTAGTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TMED3 (79603404 - 79704334 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TMED3: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TMED3
    DNA2.0 Custom Variant and Variant Library Synthesis for TMED3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    5 diseases for TMED3:    
    About MalaCards
    keratoconus    pulmonary function    cataract    prostate cancer
    prostatitis


    TMED3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TMED3

    Export disorders for TMED3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMED3 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with TMED3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (Genome Res. 2003)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Oligomeric state and stoichiometry of p24 proteins in the early secretory pathway. (PubMed id 12237308)1, 2 Jenne N.... Wieland F.T. (J. Biol. Chem. 2002)
    4. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    5. High-throughput transcriptomic and RNAi analysis identifies AIM1, ERGIC1, TMED3 and TPX2 as potential drug targets in prostate cancer. (PubMed id 22761906)1 Vainio P....Iljin K. (PLoS ONE 2012)
    6. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    7. GRP78 and Cripto form a complex at the cell surface and collaborate to inhibit transforming growth factor beta signaling and enhance cell growth. (PubMed id 17991893)1 Shani G....Gray P.C. (Mol. Cell. Biol. 2008)
    8. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
    9. Framingham Heart Study genome-wide association: results for pulmonary function measures. (PubMed id 17903307)4 Wilk J.B....O'Connor G.T. (BMC Med. Genet. 2007)
    10. Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)2 Zody M.C....Nusbaum C. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23423 HGNC: 28889 AceView: C15orf22 Ensembl:ENSG00000166557 euGenes: HUgn23423
    ECgene: TMED3 H-InvDB: TMED3

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TMED3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMED3 gene:
    Search GeneIP for patents involving TMED3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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