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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMED3 Gene

protein-coding   GIFtS: 51
GCID: GC15P079603

Transmembrane Emp24 Protein Transport Domain Containing...

(Previous names: chromosome 15 open reading frame 22, transmembrane emp24...)
(Previous symbol: C15orf22)
  4 related diseases
at
MalaCards
 

Aliases
for TMED3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Transmembrane Emp24 Protein Transport Domain Containing 31 2     p262 3
C15orf221 2 3     Chromosome 15 Open Reading Frame 221
Transmembrane Emp24 Domain Containing 31 2     P24B2
Membrane Protein P24B2 3     Integral Type I Protein2
P24 Family Protein Gamma-42 3     Transmembrane Emp24 Domain-Containing Protein 32
p24gamma42 3     

External Ids:    HGNC: 288891   Entrez Gene: 234232   Ensembl: ENSG000001665577   UniProtKB: Q9Y3Q33   

Export aliases for TMED3 gene to outside databases

Previous GC identifers: GC15P077391 GC15P056361


Summaries
for TMED3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
GeneCards Summary for TMED3 Gene: 
TMED3 (transmembrane emp24 protein transport domain containing 3) is a protein-coding gene. Diseases associated with TMED3 include keratoconus, and cataract. An important paralog of this gene is TMED5.

UniProtKB/Swiss-Prot: TMED3_HUMAN, Q9Y3Q3
Function: Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Contributes to the
coupled localization of TMED2 and TMED10 in the cis-Golgi network




Genomic Views
for TMED3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMED3 gene promoter:
         Max1   AML1a   SREBP-1c   MIF-1   SREBP-1b   AREB6   SREBP-1a   Chx10   Zic3   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TMED3 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMED3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMED3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24-q25   Ensembl cytogenetic band:  15q25.1   HGNC cytogenetic band: 15q24-q25

TMED3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMED3 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P079603:  view genomic region     (about GC identifiers)

Start:
 79,603,404 bp from pter      End:
 79,704,334 bp from pter
Size:
 100,931 bases      Orientation:
 plus strand

Proteins
for TMED3 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: TMED3_HUMAN, Q9Y3Q3 (See protein sequence)
Recommended Name: Transmembrane emp24 domain-containing protein 3 precursor  
Size: 217 amino acids; 24777 Da
Subunit: Monomer in endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment and cis-Golgi network.
Interacts (via C-terminus) with COPG1; the interaction involves dimeric TMED3; however, there are conflicting reports
on the interaction. Interacts with GORASP1 and GORASP2 (By similarity)
Subcellular location: Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane
protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Golgi apparatus, Golgi
stack membrane; Single-pass type I membrane protein (By similarity). Endoplasmic reticulum membrane; Single-pass type
I membrane protein. Cytoplasmic vesicle, COPI-coated vesicle membrane; Single-pass type I membrane protein (By
similarity). Note=Probably cycles between compartments of the early secretatory pathway
Secondary accessions: A8K069 B4DN05 Q2T9F8
Alternative splicing: 2 isoforms:  Q9Y3Q3-1   Q9Y3Q3-2   

Explore the universe of human proteins at neXtProt for TMED3: NX_Q9Y3Q3

Explore proteomics data for TMED3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y3Q3

    • TMED3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TMED3 Protein Expression
    REFSEQ proteins: NP_031390.1  
    ENSEMBL proteins: 
     ENSP00000299705   ENSP00000414983   ENSP00000446062   ENSP00000440228  

    Human Recombinant Protein Products for TMED3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TMED3
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for TMED3
    GenScript Custom Purified and Recombinant Proteins Services for TMED3
    Novus Biologicals TMED3 Protein
    Novus Biologicals TMED3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TMED3 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA12237308
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005793endoplasmic reticulum-Golgi intermediate compartment IDA12237308
    GO:0005794Golgi apparatus IDA12237308
    GO:0016021integral to membrane IEA--

    TMED3 for ontologies           About GeneDecksing



    TMED3 Antibody Products: 
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    Abcam antibodies for TMED3
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    LSBio Antibodies in human, mouse, rat for TMED3 

    Assay Products for TMED3: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for TMED3 
    Cloud-Clone Corp. CLIAs for TMED3

    Protein Domains /
    Families
    for TMED3 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 2 InterPro protein domains:
     IPR015718 P24-related
     IPR009038 GOLD

    Graphical View of Domain Structure for InterPro Entry Q9Y3Q3

    ProtoNet protein and cluster: Q9Y3Q3

    1 Blocks protein domain: IPB000348 emp24/gp25L/p24 family

    UniProtKB/Swiss-Prot: TMED3_HUMAN, Q9Y3Q3
    Similarity: Belongs to the EMP24/GP25L family
    Similarity: Contains 1 GOLD domain


    TMED3 for domains           About GeneDecksing


    Function
    for TMED3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TMED3_HUMAN, Q9Y3Q3
    Function: Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Contributes to the
    coupled localization of TMED2 and TMED10 in the cis-Golgi network

    Phenotypes:
         2 GenomeRNAi human phenotypes for TMED3:

     Decreased POU5F1-GFP protein e  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TMED3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TMED3

    miRNA
    Products:            		miRTarBase miRNAs that target TMED3:
    hsa-mir-30a (MIRT005140)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMED3
    1 QIAGEN miScript miRNA Assays for microRNA that regulate TMED3:
    hsa-miR-661
    SwitchGear 3'UTR luciferase reporter plasmid: TMED3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TMED3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMED3
    Sirion Biotech Custom design and validation of potent shRNA sequences against TMED3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TMED3
    Sirion Biotech Customized adenovirus for overexpression of TMED3
                         Customized adenovirus for potent knockdown of TMED3

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TMED3 (see all 7)
    OriGene ORF clones in mouse, rat for TMED3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TMED3 (NM_007364)
    Sino Biological Human cDNA Clone for TMED3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMED3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMED3

    Cell Line
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                         Customized inducible knockdown cell line services for TMED3
                         Customized stable overexpressing cell line services for TMED3
                         Customized inducible overexpressing cell line services for TMED3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMED3


    Pathways & Interactions
    for TMED3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMED3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/44 Interacting proteins for TMED3 (Q9Y3Q33 ENSP000002997054) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GORASP1Q9BQQ33, ENSP000003138694I2D: score=1 STRING: ENSP00000313869
    GORASP2Q9H8Y83, ENSP000002341604I2D: score=1 STRING: ENSP00000234160
    AFTPHENSP000002388554STRING: ENSP00000238855
    AP1G2ENSP000003124424STRING: ENSP00000312442
    AP1S1ENSP000003366664STRING: ENSP00000336666
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0015031protein transport IEA--

    TMED3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TMED3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMED3

    Search CenterWatch for drugs/clinical trials and news about TMED3

    Transcripts
    for TMED3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TMED3 gene: 
    NM_007364.2  

    Unigene Cluster for TMED3:

    Transmembrane emp24 protein transport domain containing 3
    Hs.513058  [show with all ESTs]
    Unigene Representative Sequence: AK075529
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000299705(uc002beu.3) ENST00000424155(uc010unj.1) ENST00000536821
    ENST00000543455(uc002bev.3) ENST00000558562
    miRNA
    Products:         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMED3
    1 QIAGEN miScript miRNA Assays for microRNA that regulate TMED3:
    hsa-miR-661
    SwitchGear 3'UTR luciferase reporter plasmid: TMED3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TMED3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMED3
    Sirion Biotech Custom design and validation of potent shRNA sequences against TMED3
    Clone
    Products:             		 OriGene clones in human, mouse for TMED3 (see all 7)
    OriGene ORF clones in mouse, rat for TMED3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TMED3 (NM_007364)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMED3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMED3
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for TMED3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMED3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMED3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMED3

    Additional mRNA sequence: 

    AJ132270.1 AK075529.1 AK222516.1 AK289434.1 AK297710.1 AK304148.1 AL109672.1 AL109673.1 
    AY358974.1 BC000027.2 BC010853.1 BC017495.1 BC022232.1 BC111547.1 CR457384.1 

    10 DOTS entries:

    DT.453957  DT.92042517  DT.100845434  DT.100845435  DT.95260376  DT.95260384  DT.100030424  DT.95260380 
    DT.121062933  DT.91758419 

    24/505 AceView cDNA sequences (see all 505):

    CR601983 CR605050 CR621451 BM669780 CB158049 CR611061 AL109713 BU731127 
    BI253912 AW152403 BM549126 AI350422 BM713559 BQ045230 AI922870 AI720391 
    CA422167 BM699123 CR618083 CR612506 BI524011 CR593572 BF445760 CA309007 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TMED3    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d
    SP1:                    -     -                 -                           
    SP2:                                            -                           
    SP3:                                      -     -                           
    SP4:                                                                        


    ECgene alternative splicing isoforms for TMED3

    Expression
    for TMED3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMED3 expression in normal human tissues (normalized intensities)      TMED3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAGCAGGAC
    TMED3 Expression
    About this image


    TMED3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Cartilage (Muscoskeletal System)    fully expand to see all 8 entries
             Meckel's Cartilage
             skeleton/cranium/chondrocranium
     
     Bone (Muscoskeletal System)    fully expand to see all 6 entries
             Endochondral Facial Bones
             skeleton/cranium/chondrocranium
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 2 entries
             skeleton/cranium/chondrocranium
     
     Head Mesenchyme (Muscoskeletal System)
             Head Mesenchyme

    See TMED3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMED3

    SOURCE GeneReport for Unigene cluster: Hs.513058
        SABiosciences Custom PCR Arrays for TMED3
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMED3
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMED3

    Orthologs
    for TMED3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TMED3 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Tmed31 , 5 transmembrane emp24 domain containing 31, 5 87.48(n)1
    93.66(a)1    		   9 (47.24 cM)5
    661111  NM_025360.21  NP_079636.21 
     896992035 
    chicken
    (Gallus gallus)    		 Aves TMED31 transmembrane emp24 protein transport domain containing more 77.67(n)
    80(a)    		   415580  XM_413948.3  XP_413948.3 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufb09b112 Danio rerio cDNA clone IMAGE6792672, partial cds 74.33(n)    BC056540.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta p24-16
    		 p24-related-1
    		 43(a)
    		 1 → many
    		 X(11745364-11746548)
    worm
    (Caenorhabditis elegans)    		 Secernentea F57B10.56
    		 Protein F57B10.5
    		 48(a)
    		 1 → many
    		 I(6562697-6563660)
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes EMP246
    		 Component of the p24 complex; binds to GPI anchor ...
    		 23(a)
    		 1 → many
    		 VII(122694-123305)


    ENSEMBL Gene Tree for TMED3 (if available)
    TreeFam Gene Tree for TMED3 (if available)

    Paralogs
    for TMED3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TMED3 gene
    TMED52  TICAM22  TMED12  TMED7-TICAM22  TMED22  TMED72  
    4 SIMAP similar genes for TMED3 using alignment to 4 protein entries:     TMED3_HUMAN (see all proteins):
    TMED7    TMED2    TMED5    RNP24

    TMED3 for paralogs           About GeneDecksing



    Genomic Variants
    for TMED3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/370 SNPs in TMED3 are shown (see all 370)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs354421711,2
    		C,F--56359742(+) GAGCTA/TCTTCA 1 -- us2k112Minor allele frequency- T:0.39NA WA CSA EA 376
    rs1461925281,2
    		--56359986(+) GCCTGA/GTTAAT 1 -- us2k10--------
    rs1892572971,2
    		--56360020(+) AACGAG/TGTTTC 1 -- us2k10--------
    rs284149671,2
    		C,F--56360029(+) TCACTA/CTGTTG 1 -- us2k11Minor allele frequency- C:0.11WA 118
    rs1806789011,2
    		--56360048(+) AGATTC/TGAACT 1 -- us2k10--------
    rs1847377691,2
    		--56360145(+) TTGTTA/CGTCTT 1 -- us2k10--------
    rs1892933471,2
    		--56360423(+) CCCGCC/TTCAGC 1 -- us2k10--------
    rs1180986091,2
    		C,F--56360670(+) ACTATG/ATTATG 1 -- us2k11Minor allele frequency- A:0.02EA 120
    rs1817111781,2
    		--56360677(+) TATGCA/GTGCAT 1 -- us2k10--------
    rs1857822541,2
    		--56360731(+) CATCCA/GTAGTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TMED3 (79603404 - 79704334 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TMED3: --
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMED3
    DNA2.0 Custom Variant and Variant Library Synthesis for TMED3

    Disorders / Diseases
    for TMED3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TMED3 for disorders           About GeneDecksing

    4 diseases for TMED3:    About MalaCards
    keratoconus    cataract    prostate cancer    prostatitis

    Genetic Association Database (GAD): TMED3

    Export disorders for TMED3 gene to outside databases

    Publications
    for TMED3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMED3 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with TMED3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Oligomeric state and stoichiometry of p24 proteins in the early secretory pathway. (PubMed id 12237308)1, 2 Jenne N.... Wieland F.T. (2002)
    4. High-throughput transcriptomic and RNAi analysis ident ifies AIM1, ERGIC1, TMED3 and TPX2 as potential drug targets in prostate cancer. (PubMed id 22761906)1 Vainio P....Iljin K. (2012)
    5. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    6. GRP78 and Cripto form a complex at the cell surface and collaborate to inhibit transforming growth factor beta signaling and enhance cell growth. (PubMed id 17991893)1 Shani G....Gray P.C. (2008)
    7. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (2007)
    8. Framingham Heart Study genome-wide association: results for pulmonary function measures. (PubMed id 17903307)4 Wilk J.B....O'Connor G.T. (2007)
    9. Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)2 Zody M.C....Nusbaum C. (2006)
    10. Coatomer, the coat protein of COPI transport vesicles, discriminates endoplasmic reticulum residents from p24 proteins. (PubMed id 16940185)2 Bethune J.... Wieland F. (2006)

    External Searches for TMED3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing TMED3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23423 HGNC: 28889 AceView: C15orf22 Ensembl:ENSG00000166557 euGenes: HUgn23423
    ECgene: TMED3 H-InvDB: TMED3

    Other Databases showing TMED3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TMED3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMED3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TMED3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TMED3 gene:
    Search GeneIP for patents involving TMED3

    GeneCards and IP:
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