TMED3 Gene

Aliases
for TMED3 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC15P077391 GC15P056361

Summaries
for TMED3 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for TMED3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000015.9  NT_010194.18  NC_018926.2  

SwitchGear Promoter luciferase reporter plasmid: TMED3 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMED3

TMED3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P079603:  view genomic region     (about GC identifiers)

Proteins
for TMED3 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for TMED3: NX_Q9Y3Q3

Explore proteomics data for TMED3 at MOPED

Post-translational modifications: 

TMED3 Human Recombinant Protein Products:

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	Cloud-Clone Corp. Proteins for TMED3
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	Search GeneTex for Proteins for TMED3
	antibodies-online proteins for TMED3 (2 products)
	antibodies-online peptides for TMED3

TMED3 Antibody Products:

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	antibodies-online antibodies for TMED3 (13 products)

TMED3 Assay Products:

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	Cloud-Clone Corp. ELISAs for TMED3 Cloud-Clone Corp. CLIAs for TMED3
	Search eBioscience for ELISAs for TMED3
	antibodies-online kits for TMED3 (6 products)

Domains /
Families
for TMED3 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q9Y3Q3

Find genes that share domains with TMED3           About GenesLikeMe

Function
for TMED3 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Phenotypes:
     2 GenomeRNAi human phenotypes for TMED3:

genOway: Develop your customized and physiologically relevant rodent model for TMED3

miRNA Products:		miRTarBase miRNAs that target TMED3: hsa-mir-30a-5p (MIRT005140)
		Block miRNA regulation of human, mouse, rat TMED3 using miScript Target Protectors
		1 qRT-PCR Assays for microRNA that regulate TMED3:
		hsa-miR-661
		SwitchGear 3'UTR luciferase reporter plasmid: TMED3 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for TMED3
		Predesigned siRNA for gene silencing in human, mouse, rat TMED3

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for TMED3

Clone Products:		OriGene clones in human, mouse for TMED3 (see all 7) OriGene ORF clones in mouse, rat for TMED3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TMED3 (NM_007364)
		Sino Biological Human cDNA Clone for TMED3
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMED3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMED3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TMED3
		Browse ESI BIO Cell Lines and PureStem Progenitors for TMED3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMED3

Localization
for TMED3 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
endoplasmic reticulum	5
golgi apparatus	5
mitochondrion	2
extracellular	1
lysosome	1
plasma membrane	1

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Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

Pathways & Interactions
for TMED3 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Gene Ontology (GO): 2 biological process terms:    About this table

Drugs & Compounds
for TMED3 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for TMED3 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for TMED3 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TMED3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CAAGCAGGAC

About this image

Bone (Muscoskeletal System)    fully expand to see all 2 entries
Endochondral Facial Bones
Cartilage (Muscoskeletal System)
Meckel's Cartilage
Colon (Gastrointestinal Tract)
Thyroid (Endocrine System)
Pancreas (Endocrine System)

Primer Products:		OriGene qPCR primer pairs and template standards for TMED3 OriGene qSTAR qPCR primer pairs in human, mouse for TMED3
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMED3
		QuantiTect SYBR Green Assays in human, mouse, rat TMED3
		QuantiFast Probe-based Assays in human, mouse, rat TMED3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMED3

Orthologs
for TMED3 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for TMED3 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for TMED3 gene

TMED5²  TICAM2²  TMED1²  TMED7-TICAM2²  TMED2²  TMED7²  

4 SIMAP similar genes for TMED3 using alignment to 4 protein entries:     TMED3_HUMAN (see all proteins):

TMED7    TMED2    TMED5    RNP24

Find genes that share paralogs with TMED3           About GenesLikeMe

Genomic Variants
for TMED3 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TMED3 (see all 370)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs354421711,2	C,F	--	56359742(+)	GAGCTA/TCTTCA	1	--	us2k1		12		NA WA CSA EA	376
rs1461925281,2		--	56359986(+)	GCCTGA/GTTAAT	1	--	us2k1		0	--	--	--	--
rs1892572971,2		--	56360020(+)	AACGAG/TGTTTC	1	--	us2k1		0	--	--	--	--
rs284149671,2	C,F	--	56360029(+)	TCACTA/CTGTTG	1	--	us2k1		1		WA	118
rs1806789011,2		--	56360048(+)	AGATTC/TGAACT	1	--	us2k1		0	--	--	--	--
rs1847377691,2		--	56360145(+)	TTGTTA/CGTCTT	1	--	us2k1		0	--	--	--	--
rs1892933471,2		--	56360423(+)	CCCGCC/TTCAGC	1	--	us2k1		0	--	--	--	--
rs1180986091,2	C,F	--	56360670(+)	ACTATG/ATTATG	1	--	us2k1		1		EA	120
rs1817111781,2		--	56360677(+)	TATGCA/GTGCAT	1	--	us2k1		0	--	--	--	--
rs1857822541,2		--	56360731(+)	CATCCA/GTAGTG	1	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for TMED3 (79603404 - 79704334 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for TMED3: --

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing TMED3

DNA2.0 Custom Variant and Variant Library Synthesis for TMED3

Disorders / Diseases
for TMED3 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for TMED3 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2, 3} Clark H.F.... Gray A.M. (Genome Res. 2003)
2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
3. Oligomeric state and stoichiometry of p24 proteins in the early secretory pathway. (PubMed id 12237308)^{1, 2} Jenne N.... Wieland F.T. (J. Biol. Chem. 2002)
4. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)¹ Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
5. High-throughput transcriptomic and RNAi analysis identifies AIM1, ERGIC1, TMED3 and TPX2 as potential drug targets in prostate cancer. (PubMed id 22761906)¹ Vainio P....Iljin K. (PLoS ONE 2012)
6. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)¹ Emanuele M.J....Elledge S.J. (Cell 2011)
7. GRP78 and Cripto form a complex at the cell surface and collaborate to inhibit transforming growth factor beta signaling and enhance cell growth. (PubMed id 17991893)¹ Shani G....Gray P.C. (Mol. Cell. Biol. 2008)
8. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)⁴ Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
9. Framingham Heart Study genome-wide association: results for pulmonary function measures. (PubMed id 17903307)⁴ Wilk J.B....O'Connor G.T. (BMC Med. Genet. 2007)
10. Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)² Zody M.C....Nusbaum C. (Nature 2006)

External Searches for TMED3 gene

Genome Databases showing TMED3 gene

Other Databases showing TMED3 gene

Specialized Databases showing TMED3 gene

Products
for TMED3 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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