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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TMED3 Gene

protein-coding GIFtS: 48
GCID: GC15P079603

transmembrane emp24 protein transport domain containing...

(Previous names: chromosome 15 open reading frame 22, transmembrane emp24...)
(Previous symbol: C15orf22)

Explore 2 diseases affiliated with
TMED3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Transmembrane Emp24 Protein Transport Domain Containing 3¹ ²		P26¹
C15orf22¹ ² ³		Chromosome 15 Open Reading Frame 22¹
Transmembrane Emp24 Domain Containing 3¹ ²		P24B²
Membrane Protein P24B² ³		P24B²
P24 Family Protein Gamma-4² ³		Integral Type I Protein²
P24gamma4¹		Transmembrane Emp24 Domain-Containing Protein 3²

External Ids:	HGNC: 28889¹	Entrez Gene: 23423²	Ensembl: ENSG00000166557⁷	UniProtKB: Q9Y3Q3³

Export aliases for TMED3 gene to outside databases

Previous GC identifers: GC15P077391 GC15P056361

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TMED3_HUMAN, Q9Y3Q3

Function: Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Contributes to the

coupled localization of TMED2 and TMED10 in the cis-Golgi network

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NC_018926.1 NT_010194.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TMED3 gene promoter:
Max1 AML1a SREBP-1c MIF-1 SREBP-1b AREB6 SREBP-1a Chx10 Zic3 c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TMED3 promoter sequence

Search SABiosciences Chromatin IP Primers for TMED3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMED3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24-q25 Ensembl cytogenetic band: 15q25.1 HGNC cytogenetic band: 15q24-q25

TMED3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMED3 gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15P079603: view genomic region (about GC identifiers)

Start:	79,603,404 bp from pter	End:	79,704,334 bp from pter
Size:	100,931 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TMED3_HUMAN, Q9Y3Q3 (See protein sequence)

Recommended Name: Transmembrane emp24 domain-containing protein 3 precursor

Size: 217 amino acids; 24777 Da

Subunit: Monomer in endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment and cis-Golgi network.

Interacts (via C-terminus) with COPG1; the interaction involves dimeric TMED3; however, there are conflicting reports

on the interaction. Interacts with GORASP1 and GORASP2 (By similarity)

Subcellular location: Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane

protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Golgi apparatus, Golgi

stack membrane; Single-pass type I membrane protein (By similarity). Endoplasmic reticulum membrane; Single-pass type

I membrane protein. Cytoplasmic vesicle, COPI-coated vesicle membrane; Single-pass type I membrane protein (By

similarity). Note=Probably cycles between compartments of the early secretatory pathway

Secondary accessions: A8K069 B4DN05 Q2T9F8

Alternative splicing: 2 isoforms: Q9Y3Q3-1 Q9Y3Q3-2

Explore the universe of human proteins at neXtProt for TMED3: NX_Q9Y3Q3

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9Y3Q3

TMED3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_031390.1

ENSEMBL proteins:

ENSP00000299705 ENSP00000414983 ENSP00000446062 ENSP00000440228

Human Recombinant Protein Products for TMED3:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Novus Biologicals TMED3 Protein Novus Biologicals TMED3 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TMED3

Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	IDA	12237308
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	IDA	12237308
GO:0005794	Golgi apparatus	IDA	12237308
GO:0016021	integral to membrane	IEA	--

TMED3 for ontologies About GeneDecksing

TMED3 Antibody Products:

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	Search ThermoFisher Antibodies for TMED3

Assay Products for TMED3:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TMED3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TMED3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TMED3 for domains About GeneDecksing

2 InterPro domains/families:

IPR015718 P24-related

IPR009038 GOLD

Graphical View of Domain Structure for InterPro Entry Q9Y3Q3

ProtoNet protein and cluster: Q9Y3Q3

1 Blocks protein family: IPB000348 emp24/gp25L/p24 family

UniProtKB/Swiss-Prot: TMED3_HUMAN, Q9Y3Q3

Similarity: Belongs to the EMP24/GP25L family

Similarity: Contains 1 GOLD domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: TMED3_HUMAN, Q9Y3Q3

Function: Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Contributes to the

coupled localization of TMED2 and TMED10 in the cis-Golgi network

Phenotypes:
2 GenomeRNAi human phenotypes for TMED3:

Decreased POU5F1-GFP protein e

Increased gamma-H2AX phosphory

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TMED3

miRNA Products:		miRTarBase miRNAs that target TMED3: hsa-mir-30a (MIRT005140)

		OriGene 3'-UTR Clone: TMED3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMED3
		1 QIAGEN miScript miRNA Assays for microRNA that regulate TMED3:
		hsa-miR-661
		SwitchGear 3'UTR luciferase reporter plasmid: TMED3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMED3 (see all 7) OriGene shRNA RFP: TMED3 OriGene siRNA: TMED3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMED3
		Sirion Biotech Custom design and validation of potent shRNA sequences against TMED3

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for TMED3
			Sirion Biotech Customized adenovirus for overexpression of TMED3 Sirion Biotech Customized adenovirus for potent knockdown of TMED3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMED3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMED3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TMED3 (NM_007364)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMED3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMED3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TMED3
		Search LifeMap BioReagents cell lines for TMED3
		Sirion Biotech Customized stable knockdown cell line services for TMED3 Sirion Biotech Customized inducible knockdown cell line services for TMED3 Sirion Biotech Customized stable overexpressing cell line services for TMED3 Sirion Biotech Customized inducible overexpressing cell line services for TMED3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMED3

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TMED3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/44 Interacting proteins for TMED3 (Q9Y3Q3³ ENSP00000299705⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 44)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GORASP1	Q9BQQ3³, ENSP00000313869⁴	I2D: score=1 STRING: ENSP00000313869
GORASP2	Q9H8Y8³, ENSP00000234160⁴	I2D: score=1 STRING: ENSP00000234160
AFTPH	ENSP00000238855⁴	STRING: ENSP00000238855
AP1G2	ENSP00000312442⁴	STRING: ENSP00000312442
AP1S1	ENSP00000336666⁴	STRING: ENSP00000336666

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006810	transport	--	--
GO:0015031	protein transport	IEA	--

TMED3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TMED3
Search CenterWatch for drugs/clinical trials and news about TMED3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TMED3 gene:

NM_007364.2

Unigene Cluster for TMED3:

Transmembrane emp24 protein transport domain containing 3

Hs.513058 [show with all ESTs]

Unigene Representative Sequence: AK075529

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000299705(uc002beu.3) ENST00000424155(uc010unj.1) ENST00000536821

ENST00000543455(uc002bev.3) ENST00000558562

miRNA Products:		OriGene 3'-UTR Clone: TMED3 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMED3
		1 QIAGEN miScript miRNA Assays for microRNA that regulate TMED3:
		hsa-miR-661
		SwitchGear 3'UTR luciferase reporter plasmid: TMED3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMED3 (see all 7) OriGene shRNA RFP: TMED3 OriGene siRNA: TMED3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMED3
		Sirion Biotech Custom design and validation of potent shRNA sequences against TMED3

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMED3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMED3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TMED3 (NM_007364)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMED3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMED3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMED3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TMED3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMED3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMED3

Additional cDNA sequence:

AJ132270.1 AK075529.1 AK222516.1 AK289434.1 AK297710.1 AK304148.1 AL109672.1 AL109673.1

AY358974.1 BC000027.2 BC010853.1 BC017495.1 BC022232.1 BC111547.1 CR457384.1

10 DOTS entries:

DT.453957 DT.92042517 DT.100845434 DT.95260376 DT.100845435 DT.95260384 DT.100030424 DT.95260380

DT.121062933 DT.91758419

24/505 AceView cDNA sequences (see all 505):

BM669041 AW152403 BI524011 AW074438 CB306603 CK823999 BM669780 CR605050

CR593572 CB158049 BM699123 CR619199 BM826269 BF445760 BM974584 CR605716

BM990265 BM992648 AI922870 CF541301 AI720391 CA412038 CA422167 CR590619

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for TMED3 About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3	^	4	^	5a	·	5b	·	5c	·	5d
SP1:							-		-						-
SP2:															-
SP3:													-		-
SP4:

ECgene alternative splicing isoforms for TMED3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TMED3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAAGCAGGAC

About this image

TMED3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/11 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 11)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Endochondral Facial Bones

Bone

Rostral Endochondral Facial Bones

Bone

Rostral Skull Membranous Bones

Bone

Bone

Cartilage

Cartilage

Cartilage

Rostral Chondrocranium

Cartilage

Rostral Synchondroses

Cartilage

Synchondroses

Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TMED3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMED3

SOURCE GeneReport for Unigene cluster: Hs.513058

SABiosciences Custom PCR Arrays for TMED3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMED3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TMED3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMED3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMED3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMED3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TMED3 gene from 4/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TMED3¹	transmembrane emp24 protein transport domain containing more	77.67(n) 80(a)		415580 XM_413948.3 XP_413948.3
zebrafish (Danio rerio)	Actinopterygii	wufb09b11²	Danio rerio cDNA clone IMAGE6792672, partial cds	74.33(n)		BC056540.1
fruit fly (Drosophila melanogaster)	Insecta	p24-1⁶	p24-related-1	44(a)	1 → many	X(11745364-11746548)
worm (Caenorhabditis elegans)	Secernentea	F57B10.5⁶	Protein F57B10.5	50(a)	1 → many	I(6562698-6563661)

ENSEMBL Gene Tree for TMED3 (if available)
TreeFam Gene Tree for TMED3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TMED3 gene

TMED5² TMED1² TICAM2² TMED7-TICAM2² TMED2² TMED7²

6 SIMAP similar genes for TMED3 using alignment to 4 protein entries: TMED3_HUMAN (see all proteins):

TIRAP3 TMED7 TMED2 TMED5 RNP24 TMED1

TMED3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs141505437^1,2		--	79601492(+)	`TGACTA/TGAGCT`	1	--	us2k¹		0	--	--	--	--
rs201491559^1,2		--	79603341(+)	`GTTGC-/GGGGGG`	1	--	us2k¹		0	--	--	--	--
rs139866809^1,2	C	--	79609962(+)	`GTGTG-/TGCCACA`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TMED3 (79603404 - 79704334 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TMED3: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMED3

DNA2.0 Custom Variant and Variant Library Synthesis for TMED3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TMED3 for disorders About GeneDecksing

2 diseases for TMED3: About MalaCards

keratoconus cataract

Export disorders for TMED3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TMED3 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with TMED3)

Utopia: connect your pdf to the dynamic
world of online information

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2, 3} Clark H.F.... Gray A.M. (2003)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Oligomeric state and stoichiometry of p24 proteins in the early secretory pathway. (PubMed id 12237308)^{1, 2} Jenne N.... Wieland F.T. (2002)
High-throughput transcriptomic and RNAi analysis ident ifies AIM1, ERGIC1, TMED3 and TPX2 as potential drug targets in prostate cancer. (PubMed id 22761906)¹ Vainio P....Iljin K. (2012)
Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)² Zody M.C....Nusbaum C. (2006)
Coatomer, the coat protein of COPI transport vesicles, discriminates endoplasmic reticulum residents from p24 proteins. (PubMed id 16940185)² Bethune J.... Wieland F. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus. (PubMed id 11739402)¹ Barr F.A.... Koerner R. (2001)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 23423	HGNC: 28889	AceView: C15orf22	Ensembl:ENSG00000166557	euGenes: HUgn23423
ECgene: TMED3	H-InvDB: TMED3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TMED3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TMED3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TMED3 gene:
Search GeneIP for patents involving TMED3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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	Browse OriGene Antibodies		OriGene shRNA RFP for TMED3
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMED3		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMED3
	OriGene Protein Over-expression Lysate for TMED3		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for TMED3		OriGene 3'-UTR Clone for TMED3
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMED3		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMED3
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for TMED3		OriGene Custom Protein Services for TMED3
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMED3
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMED3
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMED3
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMED3
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMED3
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMED3

	GenScript Custom Purified and Recombinant Proteins Services for TMED3		GenScript cDNA clones with any tag delivered in your preferred vector for TMED3
	GenScript Custom Assay Services for TMED3		GenScript Custom Superior Antibodies Services for TMED3
	GenScript Custom overexpressing Cell Line Services for TMED3		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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	Regulatory tfbs in TMED3 promoter
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
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TMED3 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for TMED3

	Gene Synthesis
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMED3

	SwitchGear 3'UTR luciferase reporter plasmids for TMED3
	SwitchGear Promoter luciferase reporter plasmids for TMED3

Search ThermoFisher Antibodies for TMED3

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMED3

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TMED3

Sirion Biotech Customized:

	stable knockdown cell line services for TMED3
	inducible knockdown cell line services for TMED3
	design and validation of potent shRNA sequences against TMED3
	adenovirus for potent knockdown of TMED3
	adenovirus for overexpression of TMED3
	stable overexpressing cell line services for TMED3
	inducible overexpressing cell line services for TMED3

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TMED3 gene at Home site.

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TMED3 Gene

transmembrane emp24 protein transport domain containing...

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TMED3 Gene

transmembrane emp24 protein transport domain containing...

Aliasesfor TMED3 gene

Summariesfor TMED3 gene

Genomic Viewsfor TMED3 gene

Proteinsfor TMED3 gene

Protein Domains /Familiesfor TMED3 gene

Functionfor TMED3 gene

Pathways & Interactionsfor TMED3 gene

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Genome Databases showing TMED3 gene

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Specialized Databases showing TMED3 gene

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for TMED3 gene

Summaries
for TMED3 gene

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for TMED3 gene

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for TMED3 gene

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Families
for TMED3 gene

Function
for TMED3 gene

Pathways & Interactions
for TMED3 gene

Drugs & Compounds
for TMED3 gene

Transcripts
for TMED3 gene

Expression
for TMED3 gene

Orthologs
for TMED3 gene

Paralogs
for TMED3 gene

Genomic Variants
for TMED3 gene

Disorders / Diseases
for TMED3 gene

Publications
for TMED3 gene

Intellectual Property
for TMED3 gene

Products
for TMED3 gene