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TMED2 Gene

protein-coding   GIFtS: 52
GCID: GC12P124069

Transmembrane Emp24 Domain Trafficking Protein 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Emp24 Domain Trafficking Protein 21 2     p24beta12 3
Membrane Protein P24A2 3     P24A2
RNP242 3     Coated Vesicle Membrane Protein2
p242 3     Transmembrane Emp24 Domain-Containing Protein 22
P24 Family Protein Beta-12 3     

External Ids:    HGNC: 169961   Entrez Gene: 109592   Ensembl: ENSG000000865987   UniProtKB: Q153633   

Export aliases for TMED2 gene to outside databases

Previous GC identifers: GC12P122595 GC12P121030


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMED2 Gene:
TMED2 (transmembrane emp24 domain trafficking protein 2) is a protein-coding gene. An important paralog of this gene is TMED5.

UniProtKB/Swiss-Prot: TMED2_HUMAN, Q15363
Function: Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in
post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo
molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII
vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act
together with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII
vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by
PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase-activating activity of ARFGAP1
towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in
trafficking of G protein-coupled receptors (GPCRs). Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from
the Golgi to the plasma membrane thus contributing to receptor resensitization. Facilitates CASR maturation and
stabilization in the early secretory pathway and increases CASR plasma membrane targeting. Proposed to be
involved in organization of intracellular membranes such as the maintenance of the Golgi apparatus. May also play
a role in the biosynthesis of secreted cargo such as eventual processing

Gene Wiki entry for TMED2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the TMED2 gene promoter:
         STAT5B   STAT1   AP-1   CUTL1   MIF-1   NF-kappaB   GATA-1   Evi-1   COMP1   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMED2 promoter sequence
   Search Chromatin IP Primers for TMED2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMED2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.31

TMED2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMED2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P124069:  view genomic region     (about GC identifiers)

Start:
124,069,076 bp from pter      End:
124,083,116 bp from pter
Size:
14,041 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TMED2_HUMAN, Q15363 (See protein sequence)
Recommended Name: Transmembrane emp24 domain-containing protein 2 precursor  
Size: 201 amino acids; 22761 Da
Subunit: Monomer and homodimer in the endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment
and Golgi. Probably oligomerizes with other members of the EMP24/GP25L family such as TMED7, TMED9 and TMED10.
Interacts with TMED10. Associates with the COPI vesicle coat (coatomer); TMED10:TMED2 heterotetramers are
proposed to be involved in coatomer association. Interacts (via C-terminus) with COPG1; the interaction involves
dimeric TMED2. Interacts with SEC23A; indicative for an association of TMED2 with the COPII vesicle coat.
Interacts with ARF1 and ARFGAP1 (By similarity). Interacts with CD59, SEC24A, SEC24B, SEC24C, SEC24D and ATLA1.
Interacts with KDELR1; the interaction is decreased by KDEL ligand (By similarity). Interacts with F2RL1; the
interaction occurs at the Golgi apparatus. Interacts with CASR (immaturely glycosylated form); the interaction
occurs in the endoplasmic reticulum-Golgi intermediate compartment or cis-Golgi. Interacts with F2RL1; the
interaction occurs at the Golgi apparatus. Interacts with GORASP1 and GORASP2 (By similarity). Found in a complex
composed at least of SURF4, TMED2 and TMED10
Miscellaneous: Ectopic expression of TMED2 alone does not result in its proper cis-Golgi network localization.
Coexpression of TMED10 is necessary, and coexpression of TMED3 and/or TMED9 is facilitating localization.
Down-regulation of TMED10 expression reduces TMED2 protein level

Explore the universe of human proteins at neXtProt for TMED2: NX_Q15363

Explore proteomics data for TMED2 at MOPED


See TMED2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_006806.1  
ENSEMBL proteins: 
 ENSP00000262225   ENSP00000405845   ENSP00000441161  
Reactome Protein details: Q15363

TMED2 Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR009038 GOLD

Graphical View of Domain Structure for InterPro Entry Q15363

ProtoNet protein and cluster: Q15363

1 Blocks protein domain: IPB000348 emp24/gp25L/p24 family

UniProtKB/Swiss-Prot: TMED2_HUMAN, Q15363
Similarity: Belongs to the EMP24/GP25L family
Similarity: Contains 1 GOLD domain


Find genes that share domains with TMED2           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: TMED2_HUMAN, Q15363
Function: Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in
post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo
molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII
vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act
together with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII
vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by
PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase-activating activity of ARFGAP1
towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in
trafficking of G protein-coupled receptors (GPCRs). Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from
the Golgi to the plasma membrane thus contributing to receptor resensitization. Facilitates CASR maturation and
stabilization in the early secretory pathway and increases CASR plasma membrane targeting. Proposed to be
involved in organization of intracellular membranes such as the maintenance of the Golgi apparatus. May also play
a role in the biosynthesis of secreted cargo such as eventual processing

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding IPI10359607
     
Find genes that share ontologies with TMED2           About GenesLikeMe


Phenotypes:
     3 GenomeRNAi human phenotypes for TMED2:
 Decreased Tat-dependent transc  Decreased p24 protein expressi  Increased cell number in S and 

     6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tmed2):
 cardiovascular system  embryogenesis  growth/size/body  limbs/digits/tail  mortality/aging 
 nervous system 

Find genes that share phenotypes with TMED2           About GenesLikeMe

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for TMED2

miRNA
Products:
    
miRTarBase miRNAs that target TMED2:
hsa-mir-7-5p (MIRT047764), hsa-mir-193b-3p (MIRT016541), hsa-mir-615-3p (MIRT039998), hsa-mir-30a-5p (MIRT005187)

Block miRNA regulation of human, mouse, rat TMED2 using miScript Target Protectors
8 qRT-PCR Assays for microRNAs that regulate TMED2:
hsa-miR-7-2* hsa-miR-3616-5p hsa-miR-3647-5p hsa-miR-1273d hsa-miR-649 hsa-miR-518a-5p hsa-miR-573 hsa-miR-7-1*
SwitchGear 3'UTR luciferase reporter plasmidTMED2 3' UTR sequence
Inhib. RNA
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GenScript: all cDNA clones in your preferred vector: TMED2 (NM_006815)
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMED2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMED2

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMED2


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
TMED2_HUMAN, Q15363: Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Cytoplasmic vesicle,
COPI-coated vesicle membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane;
Single-pass type I membrane protein. Golgi apparatus, Golgi stack membrane; Single-pass type I membrane protein.
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate
compartment membrane; Single-pass type I membrane protein. Note=Cycles between compartments of the early
secretatory pathway
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
endoplasmic reticulum5
golgi apparatus5
extracellular2
mitochondrion1
plasma membrane1

Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005783endoplasmic reticulum IDA12237308
GO:0005789endoplasmic reticulum membrane IEA--
GO:0005793endoplasmic reticulum-Golgi intermediate compartment IDA12237308
GO:0005794Golgi apparatus IDA12237308
GO:0016021integral component of membrane ISS--

Find genes that share ontologies with TMED2           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for TMED2 About    
See pathways by source

SuperPathContained pathways About
1Pre-NOTCH Expression and Processing
Pre-NOTCH Expression and Processing0.62
Pre-NOTCH Processing in Golgi0.00
2Signaling by NOTCH1 PEST Domain Mutants in Cancer
Signaling by NOTCH0.64
3Signaling by GPCR
Signal Transduction0.58


Find genes that share SuperPaths with TMED2           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways



1 Reactome Pathway for TMED2
    Pre-NOTCH Processing in Golgi


    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMED2
Interactions:

    Search GeneGlobe Interaction Network for TMED2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for TMED2 (Q153631, 3 ENSP000002622254) via UniProtKB, MINT, STRING, and/or I2D (see all 188)
InteractantInteraction Details
GeneCardExternal ID(s)
HIST1H4AP628053I2D: score=1 
HIST1H4BP628053I2D: score=1 
HIST1H4CP628053I2D: score=1 
HIST1H4DP628053I2D: score=1 
HIST1H4EP628053I2D: score=1 
About this table

Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001893maternal placenta development IEA--
GO:0006810transport ----
GO:0006886intracellular protein transport IDA--
GO:0006888ER to Golgi vesicle-mediated transport TAS--
GO:0007030Golgi organization IMP17693410

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for TMED2



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for TMED2 gene: 
NM_006815.3  

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000262225(uc001ufg.3) ENST00000438031 ENST00000543425 ENST00000544188
ENST00000509052
miRNA
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Block miRNA regulation of human, mouse, rat TMED2 using miScript Target Protectors
8 qRT-PCR Assays for microRNAs that regulate TMED2:
hsa-miR-7-2* hsa-miR-3616-5p hsa-miR-3647-5p hsa-miR-1273d hsa-miR-649 hsa-miR-518a-5p hsa-miR-573 hsa-miR-7-1*
SwitchGear 3'UTR luciferase reporter plasmidTMED2 3' UTR sequence
Inhib. RNA
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Primer
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Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMED2
  QuantiTect SYBR Green Assays in human, mouse, rat TMED2
  QuantiFast Probe-based Assays in human, mouse, rat TMED2

Selected AceView cDNA sequences (see all 821):

CR620150 AI671650 CB111784 AA447084 D19685 CB146186 AA164596 BF732887 
AI264459 BQ217467 AI014580 AA173171 AA902495 F10166 CA941694 CA445272 
CA950234 AA298291 AA999791 AA305298 AA233919 AI471088 BG778100 BI092698 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for TMED2    About this scheme

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1:                                          
SP2:                                          
SP3:                                          


ECgene alternative splicing isoforms for TMED2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TMED2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CCAAGTTTTT
TMED2 Expression
About this image


TMED2 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 25) fully expand
 
 Hypoblast (Extraembryonic Tissues)    fully expand to see all 2 entries
         Extraembryonic Visceral Endoderm Cells Extraembryonic Visceral Endoderm
         Extraembryonic Visceral Endoderm
 
 Kidney (Urinary System)
         Presumptive Podocytes Podocyte Layer
 
 Thymus (Hematopoietic System)
         Double Negative 2 Thymocytes Thymus
 
 Epithelial Cells
         Presumptive Podocytes Podocyte Layer
 
 Yolk Sac (Extraembryonic Tissues)
         Extraembryonic Visceral Endoderm Cells Extraembryonic Visceral Endoderm
TMED2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TMED2 Protein Expression
    Custom PCR Arrays for TMED2
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QuantiFast Probe-based Assays in human, mouse, rat TMED2
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMED2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for TMED2 gene from Selected species (see all 22)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tmed25
Gm215401
transmembrane emp24 domain trafficking protein 25
predicted gene, 215401
91.54(n)1
99(a)1
  5 (63.65 cM)5
1008621751  XM_003945446.21  XP_003945495.11 
 1245406955 
chicken
(Gallus gallus)
Aves TMED21 transmembrane emp24 domain trafficking protein 2 88.16(n)
97.81(a)
  416821  NM_001006186.1  NP_001006186.1 
lizard
(Anolis carolinensis)
Reptilia TMED26
transmembrane emp24 domain trafficking protein 2
91(a)
1 ↔ 1
LGb(1771294-1777698)
African clawed frog
(Xenopus laevis)
Amphibia rnp24-prov2 coated vesicle membrane protein 83.95(n)    BC044095.1 
zebrafish
(Danio rerio)
Actinopterygii wufb18g062 wufb18g06 78.83(n)   321550  BC050165.1 
fruit fly
(Drosophila melanogaster)
Insecta CHOp241 CHOp24 64.65(n)
63.74(a)
  31382  NM_131937.4  NP_572165.1 
worm
(Caenorhabditis elegans)
Secernentea sel-91 sel-9 67.03(n)
70.49(a)
  179213  NM_072744.4  NP_505145.1 
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EMP24(YGL200C)4
EMP241
Component of the p24 complex; binds to GPI anchor proteins more4
EMP241
47.86(n)1
35.2(a)1
  7(123305-122694)4
8526751, 4  NP_011315.31  NP_011315.14 


ENSEMBL Gene Tree for TMED2 (if available)
TreeFam Gene Tree for TMED2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for TMED2 gene
TMED52  TICAM22  TMED12  TMED7-TICAM22  TMED32  TMED72  
5 SIMAP similar genes for TMED2 using alignment to 3 protein entries:     TMED2_HUMAN (see all proteins):
RNP24    TMED3    TMED7    TMED9    TMED4

Find genes that share paralogs with TMED2           About GenesLikeMe


2 Pseudogenes.org Pseudogenes for TMED2
PGOHUM00000237637 PGOHUM00000262519


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TMED2 (see all 339)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 12 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs748743841,2
C,F--124067102(+) ACAGCG/ATATGT 1 -- us2k11Minor allele frequency- A:0.03WA 118
rs1157207431,2
C,F--124067115(+) ATCAAG/ATCTTG 1 -- us2k11Minor allele frequency- A:0.03WA 118
rs118313101,2
C,F,H--124067132(+) CATGAG/TTGAGG 1 -- us2k14Minor allele frequency- T:0.00NS EA 418
rs1438246091,2
--124067173(+) ACCGAA/GTCTGC 1 -- us2k10--------
rs49307141,2
C,F,A,H--124067197(-) AGCCCC/TTTCCT 1 -- us2k1 trp321Minor allele frequency- T:0.26NS EA NA WA CSA 2348
rs73150411,2
C,F--124067244(+) gataaG/Aaggtg 1 -- us2k1 tfbs31Minor allele frequency- A:0.17WA 118
rs761008511,2
C,F--124067280(+) GGAGTG/TTGCCA 1 -- us2k12Minor allele frequency- T:0.07NA EA 240
rs1810991701,2
--124067330(+) GGGCTA/GAGGGG 1 -- us2k10--------
rs1863670381,2
C--124067454(+) TGCAAC/TAGTTG 1 -- us2k10--------
rs1481813191,2
C--124067706(+) TATTGC/TGCTCC 1 -- us2k10--------

HapMap Linkage Disequilibrium report for TMED2 (124069076 - 124083116 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for TMED2:    About this table    
Variant IDTypeSubtypePubMed ID
esv2422416CNV Duplication17116639

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing TMED2
DNA2.0 Custom Variant and Variant Library Synthesis for TMED2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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Find genes that share disorders with TMED2           About GenesLikeMe

Genetic Association Database (GAD): TMED2
Human Genome Epidemiology (HuGE) Navigator: TMED2 (1 document)

Export disorders for TMED2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TMED2 gene, integrated from 10 sources (see all 35):
(articles sorted by number of sources associating them with TMED2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking. (PubMed id 8663407)1, 2, 3, 9 Blum R.... Schulz I. (J. Biol. Chem. 1996)
  2. Proteinase-activated receptors, nucleotide P2Y receptors, and mu- opioid receptor-1B are under the control of the type I transmembrane proteins p23 and p24A in post-Golgi trafficking. (PubMed id 21219331)1, 2 Luo W.... Reiser G. (J. Neurochem. 2011)
  3. The cargo receptor p24A facilitates calcium sensing receptor maturation and stabilization in the early secretory pathway. (PubMed id 20361938)1, 2 Stepanchick A. and Breitwieser G.E. (Biochem. Biophys. Res. Commun. 2010)
  4. The cargo receptors Surf4, endoplasmic reticulum-Golgi intermediate compartment (ERGIC)-53, and p25 are required to maintain the architecture of ERGIC and Golgi. (PubMed id 18287528)1, 2 Mitrovic S.... Hauri H.-P. (Mol. Biol. Cell 2008)
  5. p24A, a type I transmembrane protein, controls ARF1-dependent resensitization of protease-activated receptor-2 by influence on receptor trafficking. (PubMed id 17693410)1, 2 Luo W.... Reiser G. (J. Biol. Chem. 2007)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  7. Oligomeric state and stoichiometry of p24 proteins in the early secretory pathway. (PubMed id 12237308)1, 2 Jenne N.... Wieland F.T. (J. Biol. Chem. 2002)
  8. Decoding of sorting signals by coatomer through a GTPase switch in the COPI coat complex. (PubMed id 10761932)1, 2 Goldberg J. (Cell 2000)
  9. Localization and recycling of gp27 (hp24gamma3): complex formation with other p24 family members. (PubMed id 10359607)1, 2 Fullekrug J.... Nilsson T. (Mol. Biol. Cell 1999)
  10. gp25L/emp24/p24 protein family members of the cis-Golgi network bind both COP I and II coatomer. (PubMed id 9472029)1, 2 Dominguez M.... Nilsson T. (J. Cell Biol. 1998)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10959 HGNC: 16996 AceView: RNP24 Ensembl:ENSG00000086598 euGenes: HUgn10959
ECgene: TMED2 H-InvDB: TMED2

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TMED2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TMED2 gene:
Search GeneIP for patents involving TMED2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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