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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMED2 Gene

protein-coding   GIFtS: 55
GCID: GC12P124069

transmembrane emp24 domain trafficking protein 2
 Explore 1 disease affiliated with
TMED2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TMED2    

Aliases
for TMED2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Transmembrane Emp24 Domain Trafficking Protein 21 2     P24 Family Protein Beta-12 3
RNP241 2 3     P24beta11
P24A1 2     Coated Vesicle Membrane Protein2
Membrane Protein P24A2 3     Transmembrane Emp24 Domain-Containing Protein 22
P241     

External Ids:    HGNC: 169961   Entrez Gene: 109592   Ensembl: ENSG000000865987   UniProtKB: Q153633   

Export aliases for TMED2 gene to outside databases

Previous GC identifers: GC12P122595 GC12P121030


Summaries
for TMED2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: TMED2_HUMAN, Q15363
Function: Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in
post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo
molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII
vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act togther
with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and
lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In
COPI vesicle-mediated retrograde transport inhibits the GTPase-activating activity of ARFGAP1 towards ARF1 thus
preventing immature uncoating and allowing cargo selection to take place. Involved in trafficking of G protein-coupled
receptors (GPCRs). Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus
contributing to receptor resensitization. Facilitates CASR maturation and stabilization in the early secretory pathway
and increases CASR plasma membrane targeting. Proposed to be involved in organization of intracellular membranes such
as the maintenance of the Golgi apparatus. May also play a role in the biosynthesis of secreted cargo such as eventual
processing

Gene Wiki entry for TMED2


Genomic Views
for TMED2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009755.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMED2 gene promoter:
         STAT5B   STAT1   AP-1   CUTL1   MIF-1   NF-kappaB   GATA-1   Evi-1   COMP1   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TMED2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMED2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMED2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.31

TMED2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMED2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P124069:  view genomic region     (about GC identifiers)

Start:
 124,069,076 bp from pter      End:
 124,083,116 bp from pter
Size:
 14,041 bases      Orientation:
 plus strand

Proteins
for TMED2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TMED2_HUMAN, Q15363 (See protein sequence)
Recommended Name: Transmembrane emp24 domain-containing protein 2 precursor  
Size: 201 amino acids; 22761 Da
Subunit: Monomer and homodimer in the endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment and
Golgi. Probably oligomerizes with other members of the EMP24/GP25L family such as TMED7, TMED9 and TMED10. Interacts
with TMED10. Associates with the COPI vesicle coat (coatomer); TMED10:TMED2 heterotetramers are proposed to be
involved in coatomer association. Interacts (via C-terminus) with COPG1; the interaction involves dimeric TMED2.
Interacts with SEC23A; indicative for an association of TMED2 with the COPII vesicle coat. Interacts with ARF1 and
ARFGAP1 (By similarity). Interacts with CD59, SEC24A, SEC24B, SEC24C, SEC24D and ATLA1. Interacts with KDELR1; the
interaction is decreased by KDEL ligand (By similarity). Interacts with F2RL1; the interaction occurs at the Golgi
apparatus. Interacts with CASR (immaturely glycosylated form); the interaction occurs in the endoplasmic
reticulum-Golgi intermediate compartment or cis-Golgi. Interacts with F2RL1; the interaction occurs at the Golgi
apparatus. Interacts with GORASP1 and GORASP2 (By similarity). Found in a complex composed at least of SURF4, TMED2
and TMED10
Subcellular location: Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Cytoplasmic vesicle,
COPI-coated vesicle membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane;
Single-pass type I membrane protein. Golgi apparatus, Golgi stack membrane; Single-pass type I membrane protein.
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate
compartment membrane; Single-pass type I membrane protein. Note=Cycles between compartments of the early secretatory
pathway
Miscellaneous: Ectopic expression of TMED2 alone does not result in its proper cis-Golgi network localization.
Coexpression of TMED10 is necessary, and coexpression of TMED3 and/or TMED9 is facilitating localization.
Down-regulation of TMED10 expression reduces TMED2 protein level

Explore the universe of human proteins at neXtProt for TMED2: NX_Q15363

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q15363

    • TMED2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006806.1  
    ENSEMBL proteins: 
     ENSP00000262225   ENSP00000405845   ENSP00000441161  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: TMED2
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    Novus Biologicals TMED2 Protein
    Novus Biologicals TMED2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TMED2

    Gene Ontology (GO): 5/12 cellular component terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA12237308
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005792microsome ----
    GO:0005793endoplasmic reticulum-Golgi intermediate compartment IDA12237308
    GO:0005794Golgi apparatus IDA12237308


    TMED2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for TMED2

    Protein Domains /
    Families
    for TMED2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TMED2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR009038 GOLD

    Graphical View of Domain Structure for InterPro Entry Q15363

    ProtoNet protein and cluster: Q15363

    1 Blocks protein family: IPB000348 emp24/gp25L/p24 family

    UniProtKB/Swiss-Prot: TMED2_HUMAN, Q15363
    Similarity: Belongs to the EMP24/GP25L family
    Similarity: Contains 1 GOLD domain


    Function
    for TMED2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TMED2_HUMAN, Q15363
    Function: Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in
    post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo
    molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII
    vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act togther
    with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and
    lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In
    COPI vesicle-mediated retrograde transport inhibits the GTPase-activating activity of ARFGAP1 towards ARF1 thus
    preventing immature uncoating and allowing cargo selection to take place. Involved in trafficking of G protein-coupled
    receptors (GPCRs). Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus
    contributing to receptor resensitization. Facilitates CASR maturation and stabilization in the early secretory pathway
    and increases CASR plasma membrane targeting. Proposed to be involved in organization of intracellular membranes such
    as the maintenance of the Golgi apparatus. May also play a role in the biosynthesis of secreted cargo such as eventual
    processing

    miRNA
    Products:            		miRTarBase miRNAs that target TMED2:
    hsa-mir-30a (MIRT005187)

    OriGene 3'-UTR Clone: TMED2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMED2
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate TMED2:
    hsa-miR-7-2* hsa-miR-3616-5p hsa-miR-3647-5p hsa-miR-1273d hsa-miR-649 hsa-miR-518a-5p hsa-miR-573 hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmid: TMED2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMED2 (see all 7)
    OriGene shRNA RFP: TMED2
    OriGene siRNA: TMED2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMED2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TMED2

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMED2 (see all 3)
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    Cell Line
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    Search LifeMap BioReagents cell lines for TMED2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMED2

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--


    TMED2 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for TMED2:
     Decreased Tat-dependent transc  Decreased p24 protein expressi  Increased cell number in S and 

    Animal Models:
         6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Tmed2):
     cardiovascular system  embryogenesis  growth/size  limbs/digits/tail  mortality/aging 
     nervous system 

    TMED2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TMED2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMED2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/125 Interacting proteins for TMED2 (Q153631, 3 ENSP000002622254) via UniProtKB, MINT, STRING, and/or I2D (see all 125)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001843neural tube closure IEA--
    GO:0001892embryonic placenta development IEA--
    GO:0001893maternal placenta development IEA--
    GO:0001947heart looping IEA--
    GO:0006810transport ----


    TMED2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TMED2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMED2
    Search CenterWatch for drugs/clinical trials and news about TMED2 

    Transcripts
    for TMED2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TMED2 gene: 
    NM_006815.3  

    Unigene Cluster for TMED2:

    Transmembrane emp24 domain trafficking protein 2
    Hs.733403  [show with all ESTs]
    Unigene Representative Sequence: NM_006815
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262225(uc001ufg.3) ENST00000438031 ENST00000543425 ENST00000544188
    ENST00000536875 ENST00000509052

    miRNA
    Products:             		 OriGene 3'-UTR Clone: TMED2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMED2
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate TMED2:
    hsa-miR-7-2* hsa-miR-3616-5p hsa-miR-3647-5p hsa-miR-1273d hsa-miR-649 hsa-miR-518a-5p hsa-miR-573 hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmid: TMED2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMED2 (see all 7)
    OriGene shRNA RFP: TMED2
    OriGene siRNA: TMED2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMED2
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMED2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMED2
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TMED2 (NM_006815)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMED2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMED2 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMED2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMED2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMED2

    Additional cDNA sequence: 

    AK024976.1 AK298167.1 AK303189.1 AK312975.1 BC025957.1 CR541663.1 CR541682.1 X92098.1 

    24/32 DOTS entries (see all 32):

    DT.100679824  DT.75193702  DT.91979006  DT.100676134  DT.100679813  DT.100758886  DT.100679819  DT.100679818 
    DT.100679821  DT.100679822  DT.97855376  DT.100679814  DT.97855375  DT.92462046  DT.95263835  DT.95263842 
    DT.100679815  DT.121107135  DT.95263820  DT.100679820  DT.100686400  DT.121107139  DT.100652913  DT.100679825 

    24/821 AceView cDNA sequences (see all 821):

    AA233919 CR620150 C02110 BE501944 BI092698 AI758393 AA773432 AA425490 
    AA580607 AA587489 AA173171 BM685416 AA625676 CA435939 BI962876 BQ431089 
    AA999791 BM798002 AI264459 AA305298 AA298291 AA370878 AA971825 AI318399 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for TMED2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
    SP1:                                          
    SP2:                                          
    SP3:                                          


    ECgene alternative splicing isoforms for TMED2

    Expression
    for TMED2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMED2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCAAGTTTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TMED2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Skeletal MuscleHyoid Arch MusclesMononuclear MyocytesSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMononuclear MyocytesSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TMED2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMED2

    SOURCE GeneReport for Unigene cluster: Hs.733403
        SABiosciences Custom PCR Arrays for TMED2
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMED2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMED2

    Orthologs
    for TMED2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TMED2 gene from 7/30 species (see all 30)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves TMED21 transmembrane emp24 domain trafficking protein 2 85.9(n)
    93.03(a)    		   416821  NM_001006186.1  NP_001006186.1 
    lizard
    (Anolis carolinensis)    		 Reptilia TMED26
    		 --
    		 91(a)
    		 1 ↔ 1
    		 LGb(1771297-1777698)
    African clawed frog
    (Xenopus laevis)    		 Amphibia rnp24-prov2 coated vesicle membrane protein 83.95(n)    BC044095.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufb18g062 wufb18g06 78.83(n)   321550  BC050165.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CHOp241 CG3564-PA 63.99(n)
    62.31(a)    		   31382  NM_131937.3  NP_572165.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea sel-91 Protein SEL-9 66.84(n)
    69.27(a)    		   179213  NM_072744.3  NP_505145.1 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes EMP24(YGL200C)4
    EMP241    		 Component of the p24 complex; binds to GPI anchor proteins more4
    Emp24p1    		 47.72(n)1
    34.52(a)1    		   7(123305-122694)4
    8526751, 4  NP_011315.31  NP_011315.14 


    ENSEMBL Gene Tree for TMED2 (if available)
    TreeFam Gene Tree for TMED2 (if available) 

    Paralogs
    for TMED2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TMED2 gene
    TMED52  TMED12  TICAM22  TMED7-TICAM22  TMED32  TMED72  
    6 SIMAP similar genes for TMED2 using alignment to 3 protein entries:     TMED2_HUMAN (see all proteins):
    RNP24    TMED3    TMED7    TIRAP3    TMED9    TMED4

    TMED2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for TMED2
    PGOHUM00000237637 PGOHUM00000262519


    Genomic Variants
    for TMED2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/287 NCBI SNPs in TMED2 are shown (see all 287)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs748743841,2
    		C,F,--124067102(+) ACAGCG/ATATGT 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1157207431,2
    		F,--124067115(+) ATCAAG/ATCTTG 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs118313101,2
    		C,H,--124067132(+) CATGAG/TTGAGG 1 -- us2k14Minor allele frequency- T:0.00NS EA 418
    rs1438246091,2
    		--124067173(+) ACCGAA/GTCTGC 1 -- us2k10--------
    rs49307141,2
    		C,F,A,H,--124067197(-) AGCCCC/TTTCCT 1 -- us2k1 trp321Minor allele frequency- T:0.26NS EA NA WA CSA 2348
    rs73150411,2
    		C,F,--124067244(+) gataaG/Aaggtg 1 -- us2k1 tfbs31Minor allele frequency- A:0.17WA 118
    rs761008511,2
    		F,--124067280(+) GGAGTG/TTGCCA 1 -- us2k12Minor allele frequency- T:0.07NA EA 240
    rs1810991701,2
    		--124067330(+) GGGCTA/GAGGGG 1 -- us2k10--------
    rs1863670381,2
    		--124067454(+) TGCAAC/TAGTTG 1 -- us2k10--------
    rs1481813191,2
    		--124067706(+) TATTGC/TGCTCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TMED2 (124069076 - 124083116 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for TMED2
         1 CNV: 5313

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    Disorders / Diseases
    for TMED2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TMED2 for disorders           About GeneDecksing

    1 disease for TMED2:    About MalaCards
    pancreatitis

    Human Genome Epidemiology (HuGE) Navigator: TMED2 (1 document)

    Export disorders for TMED2 gene to outside databases

    Publications
    for TMED2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMED2 gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with TMED2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking. (PubMed id 8663407)1, 2, 3, 9 Blum R....Schulz I. (1996)
    2. Proteinase-activated receptors, nucleotide P2Y recept ors, and I1-opioid receptor-1B are under the control of the type I transmembrane proteins p23 and p24A in post-Golgi trafficking. (PubMed id 21219331)1, 2 Luo W....Reiser G. (2011)
    3. The cargo receptor p24A facilitates calcium sensing r eceptor maturation and stabilization in the early secretory pathway. (PubMed id 20361938)1, 2 Stepanchick A. and Breitwieser G.E. (2010)
    4. The cargo receptors Surf4, endoplasmic reticulum-Golgi intermediate compartment (ERGIC)-53, and p25 are required to maintain the architecture of ERGIC and Golgi. (PubMed id 18287528)1, 2 Mitrovic S.... Hauri H.-P. (2008)
    5. p24A, a type I transmembrane protein, controls ARF1-dependent resensitization of protease-activated receptor-2 by influence on receptor trafficking. (PubMed id 17693410)1, 2 Luo W....Reiser G. (2007)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Oligomeric state and stoichiometry of p24 proteins in the early secretory pathway. (PubMed id 12237308)1, 2 Jenne N.... Wieland F.T. (2002)
    8. Decoding of sorting signals by coatomer through a GTPase switch in the COPI coat complex. (PubMed id 10761932)1, 2 Goldberg J. (2000)
    9. Localization and recycling of gp27 (hp24gamma3): comp lex formation with other p24 family members. (PubMed id 10359607)1, 2 FA1llekrug J....Nilsson T. (1999)
    10. TMED2/p24b1 is expressed in all gestational stages of human placentas and in choriocarcinoma cell lines. (PubMed id 22212250)1 Zakariyah A....Jerome-Majewska L. (2012)

    External Searches for TMED2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TMED2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10959 HGNC: 16996 AceView: RNP24 Ensembl:ENSG00000086598 euGenes: HUgn10959
    ECgene: TMED2 H-InvDB: TMED2

    Other Databases showing TMED2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TMED2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMED2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TMED2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TMED2 gene:
    Search GeneIP for patents involving TMED2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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