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Aliases for TMED2 Gene

Aliases for TMED2 Gene

  • Transmembrane P24 Trafficking Protein 2 2 3 5
  • Transmembrane Emp24 Domain Trafficking Protein 2 2 3
  • P24 Family Protein Beta-1 3 4
  • Membrane Protein P24A 3 4
  • P24beta1 3 4
  • RNP24 3 4
  • P24 3 4
  • Coated Vesicle Membrane Protein 3
  • P24b1 3
  • P24A 3

External Ids for TMED2 Gene

Previous GeneCards Identifiers for TMED2 Gene

  • GC12P122595
  • GC12P124069
  • GC12P121030

Summaries for TMED2 Gene

GeneCards Summary for TMED2 Gene

TMED2 (Transmembrane P24 Trafficking Protein 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Transport to the Golgi and subsequent modification. An important paralog of this gene is TMED5.

UniProtKB/Swiss-Prot for TMED2 Gene

  • Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase-activating activity of ARFGAP1 towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Facilitates CASR maturation and stabilization in the early secretory pathway and increases CASR plasma membrane targeting. Proposed to be involved in organization of intracellular membranes such as the maintenance of the Golgi apparatus. May also play a role in the biosynthesis of secreted cargo such as eventual processing.

Gene Wiki entry for TMED2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMED2 Gene

Genomics for TMED2 Gene

Regulatory Elements for TMED2 Gene

Promoters for TMED2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMED2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMED2 Gene

Chromosome:
12
Start:
123,584,529 bp from pter
End:
123,598,577 bp from pter
Size:
14,049 bases
Orientation:
Plus strand

Genomic View for TMED2 Gene

Genes around TMED2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMED2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMED2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMED2 Gene

Proteins for TMED2 Gene

  • Protein details for TMED2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15363-TMED2_HUMAN
    Recommended name:
    Transmembrane emp24 domain-containing protein 2
    Protein Accession:
    Q15363

    Protein attributes for TMED2 Gene

    Size:
    201 amino acids
    Molecular mass:
    22761 Da
    Quaternary structure:
    • Monomer and homodimer in the endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment and Golgi. Probably oligomerizes with other members of the EMP24/GP25L family such as TMED7, TMED9 and TMED10. Interacts with TMED10. Associates with the COPI vesicle coat (coatomer); TMED10:TMED2 heterotetramers are proposed to be involved in coatomer association. Interacts (via C-terminus) with COPG1; the interaction involves dimeric TMED2. Interacts with SEC23A; indicative for an association of TMED2 with the COPII vesicle coat. Interacts with ARF1 and ARFGAP1 (By similarity). Interacts with CD59, SEC24A, SEC24B, SEC24C, SEC24D and ATLA1. Interacts with KDELR1; the interaction is decreased by KDEL ligand (By similarity). Interacts with F2RL1; the interaction occurs at the Golgi apparatus. Interacts with CASR (immaturely glycosylated form); the interaction occurs in the endoplasmic reticulum-Golgi intermediate compartment or cis-Golgi. Interacts with F2RL1; the interaction occurs at the Golgi apparatus. Interacts with GORASP1 and GORASP2 (By similarity). Found in a complex composed at least of SURF4, TMED2 and TMED10.
    Miscellaneous:
    • Ectopic expression of TMED2 alone does not result in its proper cis-Golgi network localization. Coexpression of TMED10 is necessary, and coexpression of TMED3 and/or TMED9 is facilitating localization. Down-regulation of TMED10 expression reduces TMED2 protein level.

neXtProt entry for TMED2 Gene

Proteomics data for TMED2 Gene at MOPED

Post-translational modifications for TMED2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMED2 Gene

No data available for DME Specific Peptides for TMED2 Gene

Domains & Families for TMED2 Gene

Gene Families for TMED2 Gene

Protein Domains for TMED2 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q15363

UniProtKB/Swiss-Prot:

TMED2_HUMAN :
  • Contains 1 GOLD domain.
  • Belongs to the EMP24/GP25L family.
Domain:
  • Contains 1 GOLD domain.
Family:
  • Belongs to the EMP24/GP25L family.
genes like me logo Genes that share domains with TMED2: view

Function for TMED2 Gene

Molecular function for TMED2 Gene

UniProtKB/Swiss-Prot Function:
Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase-activating activity of ARFGAP1 towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Facilitates CASR maturation and stabilization in the early secretory pathway and increases CASR plasma membrane targeting. Proposed to be involved in organization of intracellular membranes such as the maintenance of the Golgi apparatus. May also play a role in the biosynthesis of secreted cargo such as eventual processing.
genes like me logo Genes that share phenotypes with TMED2: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMED2 Gene

Localization for TMED2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMED2 Gene

Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, COPI-coated vesicle membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Golgi apparatus, Golgi stack membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Note=Cycles between compartments of the early secretatory pathway. {ECO:0000269 PubMed:12237308}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMED2 Gene COMPARTMENTS Subcellular localization image for TMED2 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
extracellular 2
plasma membrane 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TMED2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0012507 ER to Golgi transport vesicle membrane TAS --
GO:0030133 transport vesicle TAS --
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane TAS --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with TMED2: view

Pathways & Interactions for TMED2 Gene

genes like me logo Genes that share pathways with TMED2: view

Gene Ontology (GO) - Biological Process for TMED2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001756 somitogenesis IEA --
GO:0001892 embryonic placenta development IEA --
GO:0001947 heart looping IEA --
GO:0006810 transport IEA --
GO:0007030 Golgi organization IMP 17693410
genes like me logo Genes that share ontologies with TMED2: view

No data available for SIGNOR curated interactions for TMED2 Gene

Drugs & Compounds for TMED2 Gene

No Compound Related Data Available

Transcripts for TMED2 Gene

Unigene Clusters for TMED2 Gene

Transmembrane emp24 domain trafficking protein 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMED2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1:
SP2:
SP3:

Relevant External Links for TMED2 Gene

GeneLoc Exon Structure for
TMED2
ECgene alternative splicing isoforms for
TMED2

Expression for TMED2 Gene

mRNA expression in normal human tissues for TMED2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMED2 Gene



SOURCE GeneReport for Unigene cluster for TMED2 Gene Hs.733403

genes like me logo Genes that share expression patterns with TMED2: view

Protein tissue co-expression partners for TMED2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMED2 Gene

Orthologs for TMED2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TMED2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMED2 35
  • 99.17 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia TMED2 36
  • 100 (a)
OneToOne
TMED2 35
  • 93.03 (n)
  • 99.5 (a)
dog
(Canis familiaris)
Mammalia TMED2 35
  • 94.03 (n)
  • 99.5 (a)
TMED2 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmed2 16
Tmed2 36
  • 99 (a)
OneToOne
Gm21540 35
  • 91.54 (n)
  • 99 (a)
oppossum
(Monodelphis domestica)
Mammalia TMED2 36
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMED2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmed2 35
  • 92.21 (n)
  • 99.5 (a)
chicken
(Gallus gallus)
Aves TMED2 35
  • 88.16 (n)
  • 97.81 (a)
TMED2 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMED2 36
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia rnp24-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8778 35
tmed2 35
  • 85.06 (n)
  • 98.91 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11035 35
zebrafish
(Danio rerio)
Actinopterygii tmed2 35
  • 80.15 (n)
  • 94.54 (a)
wufb18g06 35
tmed2 36
  • 88 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004743 35
  • 63.19 (n)
  • 65.93 (a)
fruit fly
(Drosophila melanogaster)
Insecta CHOp24 36
  • 59 (a)
OneToOne
CHOp24 35
  • 64.65 (n)
  • 63.74 (a)
worm
(Caenorhabditis elegans)
Secernentea sel-9 36
  • 67 (a)
OneToOne
sel-9 35
  • 67.03 (n)
  • 70.49 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EMP24 36
  • 33 (a)
OneToMany
EMP24 38
EMP24 35
  • 47.86 (n)
  • 35.2 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F12518g 35
  • 45.52 (n)
  • 34.86 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08339 35
  • 50.1 (n)
  • 40 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes emp24 35
  • 45.25 (n)
  • 32.96 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1779 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5670 36
  • 73 (a)
OneToOne
Species with no ortholog for TMED2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMED2 Gene

ENSEMBL:
Gene Tree for TMED2 (if available)
TreeFam:
Gene Tree for TMED2 (if available)

Paralogs for TMED2 Gene

Paralogs for TMED2 Gene

(5) SIMAP similar genes for TMED2 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for TMED2 Gene

genes like me logo Genes that share paralogs with TMED2: view

Variants for TMED2 Gene

Sequence variations from dbSNP and Humsavar for TMED2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs952360 -- 123,592,259(-) ACAAG(A/G)TAAGA intron-variant
rs2878045 -- 123,595,128(-) tctca(A/G)actcc intron-variant
rs3168402 -- 123,598,071(+) TAAAA(A/G)ATGTA utr-variant-3-prime
rs4930712 -- 123,596,135(-) TCACT(C/T)TTGCA intron-variant
rs4930713 -- 123,596,072(-) CTATA(C/T)TCTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMED2 Gene

Variant ID Type Subtype PubMed ID
esv2422416 CNV Duplication 17116639

Variation tolerance for TMED2 Gene

Residual Variation Intolerance Score: 28.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMED2 Gene

HapMap Linkage Disequilibrium report
TMED2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMED2 Gene

Disorders for TMED2 Gene

Relevant External Links for TMED2

Genetic Association Database (GAD)
TMED2
Human Genome Epidemiology (HuGE) Navigator
TMED2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMED2

No disorders were found for TMED2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMED2 Gene

Publications for TMED2 Gene

  1. Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking. (PMID: 8663407) Blum R. … Schulz I. (J. Biol. Chem. 1996) 2 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. Common genetic variants associated with cognitive performance identified using the proxy-phenotype method. (PMID: 25201988) Rietveld C.A. … Koellinger P.D. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3

Products for TMED2 Gene

Sources for TMED2 Gene

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