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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMED2 Gene

protein-coding   GIFtS: 56
GCID: GC12P124069

Transmembrane Emp24 Domain Trafficking Protein 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transmembrane Emp24 Domain Trafficking Protein 21 2     p24beta12 3
Membrane Protein P24A2 3     P24A2
RNP242 3     Coated Vesicle Membrane Protein2
p242 3     Transmembrane Emp24 Domain-Containing Protein 22
P24 Family Protein Beta-12 3     

External Ids:    HGNC: 169961   Entrez Gene: 109592   Ensembl: ENSG000000865987   UniProtKB: Q153633   

Export aliases for TMED2 gene to outside databases

Previous GC identifers: GC12P122595 GC12P121030


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TMED2 Gene: 
TMED2 (transmembrane emp24 domain trafficking protein 2) is a protein-coding gene. Diseases associated with TMED2 include choriocarcinoma, and pancreatitis. GO annotations related to this gene include protein binding. An important paralog of this gene is TMED5.

UniProtKB/Swiss-Prot: TMED2_HUMAN, Q15363
Function: Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in
post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo
molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII
vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act
togther with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII
vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by
PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase-activating activity of ARFGAP1
towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in
trafficking of G protein-coupled receptors (GPCRs). Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from
the Golgi to the plasma membrane thus contributing to receptor resensitization. Facilitates CASR maturation and
stabilization in the early secretory pathway and increases CASR plasma membrane targeting. Proposed to be
involved in organization of intracellular membranes such as the maintenance of the Golgi apparatus. May also play
a role in the biosynthesis of secreted cargo such as eventual processing

Gene Wiki entry for TMED2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009755.19  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMED2 gene promoter:
         STAT5B   STAT1   AP-1   CUTL1   MIF-1   NF-kappaB   GATA-1   Evi-1   COMP1   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMED2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMED2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMED2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.31

TMED2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMED2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P124069:  view genomic region     (about GC identifiers)

Start:
124,069,076 bp from pter      End:
124,083,116 bp from pter
Size:
14,041 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TMED2_HUMAN, Q15363 (See protein sequence)
Recommended Name: Transmembrane emp24 domain-containing protein 2 precursor  
Size: 201 amino acids; 22761 Da
Subunit: Monomer and homodimer in the endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment
and Golgi. Probably oligomerizes with other members of the EMP24/GP25L family such as TMED7, TMED9 and TMED10.
Interacts with TMED10. Associates with the COPI vesicle coat (coatomer); TMED10:TMED2 heterotetramers are
proposed to be involved in coatomer association. Interacts (via C-terminus) with COPG1; the interaction involves
dimeric TMED2. Interacts with SEC23A; indicative for an association of TMED2 with the COPII vesicle coat.
Interacts with ARF1 and ARFGAP1 (By similarity). Interacts with CD59, SEC24A, SEC24B, SEC24C, SEC24D and ATLA1.
Interacts with KDELR1; the interaction is decreased by KDEL ligand (By similarity). Interacts with F2RL1; the
interaction occurs at the Golgi apparatus. Interacts with CASR (immaturely glycosylated form); the interaction
occurs in the endoplasmic reticulum-Golgi intermediate compartment or cis-Golgi. Interacts with F2RL1; the
interaction occurs at the Golgi apparatus. Interacts with GORASP1 and GORASP2 (By similarity). Found in a complex
composed at least of SURF4, TMED2 and TMED10
Subcellular location: Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Cytoplasmic vesicle,
COPI-coated vesicle membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane;
Single-pass type I membrane protein. Golgi apparatus, Golgi stack membrane; Single-pass type I membrane protein.
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate
compartment membrane; Single-pass type I membrane protein. Note=Cycles between compartments of the early
secretatory pathway
Miscellaneous: Ectopic expression of TMED2 alone does not result in its proper cis-Golgi network localization.
Coexpression of TMED10 is necessary, and coexpression of TMED3 and/or TMED9 is facilitating localization.
Down-regulation of TMED10 expression reduces TMED2 protein level

Explore the universe of human proteins at neXtProt for TMED2: NX_Q15363

Explore proteomics data for TMED2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15363

  • TMED2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TMED2 Protein Expression
    REFSEQ proteins: NP_006806.1  
    ENSEMBL proteins: 
     ENSP00000262225   ENSP00000405845   ENSP00000441161  

    Human Recombinant Protein Products for TMED2: 
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    Novus Biologicals TMED2 Protein
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TMED2 

    Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA12237308
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005793endoplasmic reticulum-Golgi intermediate compartment IDA12237308
    GO:0005794Golgi apparatus IDA12237308
    GO:0016021integral to membrane ISS--

    TMED2 for ontologies           About GeneDecksing



    TMED2 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR009038 GOLD

    Graphical View of Domain Structure for InterPro Entry Q15363

    ProtoNet protein and cluster: Q15363

    1 Blocks protein domain: IPB000348 emp24/gp25L/p24 family

    UniProtKB/Swiss-Prot: TMED2_HUMAN, Q15363
    Similarity: Belongs to the EMP24/GP25L family
    Similarity: Contains 1 GOLD domain


    TMED2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TMED2_HUMAN, Q15363
    Function: Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in
    post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo
    molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII
    vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act
    togther with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII
    vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by
    PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase-activating activity of ARFGAP1
    towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in
    trafficking of G protein-coupled receptors (GPCRs). Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from
    the Golgi to the plasma membrane thus contributing to receptor resensitization. Facilitates CASR maturation and
    stabilization in the early secretory pathway and increases CASR plasma membrane targeting. Proposed to be
    involved in organization of intracellular membranes such as the maintenance of the Golgi apparatus. May also play
    a role in the biosynthesis of secreted cargo such as eventual processing

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10359607
         
    TMED2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for TMED2:
     Decreased Tat-dependent transc  Decreased p24 protein expressi  Increased cell number in S and 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tmed2):
     cardiovascular system  embryogenesis  growth/size  limbs/digits/tail  mortality/aging 
     nervous system 

    TMED2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TMED2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TMED2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMED2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMED2 

    miRNA
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    miRTarBase miRNAs that target TMED2:
    hsa-mir-30a (MIRT005187)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMED2
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate TMED2:
    hsa-miR-7-2* hsa-miR-3616-5p hsa-miR-3647-5p hsa-miR-1273d hsa-miR-649 hsa-miR-518a-5p hsa-miR-573 hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmidTMED2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    Sino Biological Human cDNA Clone for TMED2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMED2
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMED2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMED2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/125 Interacting proteins for TMED2 (Q153631, 3 ENSP000002622254) via UniProtKB, MINT, STRING, and/or I2D (see all 125)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001843neural tube closure ----
    GO:0001892embryonic placenta development ----
    GO:0001893maternal placenta development IEA--
    GO:0001947heart looping ----
    GO:0006810transport ----

    TMED2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMED2

    Search CenterWatch for drugs/clinical trials and news about TMED2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TMED2 gene: 
    NM_006815.3  

    Unigene Cluster for TMED2:

    Transmembrane emp24 domain trafficking protein 2
    Hs.733403  [show with all ESTs]
    Unigene Representative Sequence: NM_006815
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262225(uc001ufg.3) ENST00000438031 ENST00000543425 ENST00000544188
    ENST00000509052
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMED2
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate TMED2:
    hsa-miR-7-2* hsa-miR-3616-5p hsa-miR-3647-5p hsa-miR-1273d hsa-miR-649 hsa-miR-518a-5p hsa-miR-573 hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmidTMED2 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Clone
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    OriGene clones in human, mouse for TMED2 (see all 7)
    OriGene ORF clones in mouse, rat for TMED2
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    GenScript: all cDNA clones in your preferred vector: TMED2 (NM_006815)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMED2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMED2
    Sirion Biotech Customized lentivirus for stable overexpression of TMED2 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMED2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMED2

    Additional mRNA sequence: 

    AK024976.1 AK298167.1 AK303189.1 AK312975.1 BC025957.1 CR541663.1 CR541682.1 X92098.1 

    24/32 DOTS entries (see all 32):

    DT.100679824  DT.75193702  DT.91979006  DT.100676134  DT.100679813  DT.100758886  DT.100679819  DT.100679818 
    DT.100679821  DT.100679822  DT.97855376  DT.100679814  DT.97855375  DT.92462046  DT.95263835  DT.95263842 
    DT.100679815  DT.121107135  DT.95263820  DT.100031694  DT.100679820  DT.100686400  DT.121107139  DT.100652913 

    24/821 AceView cDNA sequences (see all 821):

    BF732887 AA379577 AA447084 BI962876 AA902495 F10166 CA941694 CA445272 
    CA950234 AA298291 AA999791 AA305298 AA233919 AI471088 AA173171 AV658574 
    AI014580 BQ217467 AA971825 BM903973 AA164596 AA284761 AA911674 AI620027 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for TMED2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
    SP1:                                          
    SP2:                                          
    SP3:                                          


    ECgene alternative splicing isoforms for TMED2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMED2 expression in normal human tissues (normalized intensities)      TMED2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAAGTTTTT
    TMED2 Expression
    About this image


    TMED2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Hypoblast (Extraembryonic Tissues)    fully expand to see all 2 entries
             Extraembryonic Visceral Endoderm Cells Extraembryonic Visceral Endoderm
             Extraembryonic Visceral Endoderm
     
     Primitive Streak (Early Embryonic Tissues)    fully expand to see all 2 entries
             Primitive Streak Cells Primitive Streak
             Primitive Streak
     
     Thymus (Hematopoietic System)
             Double Negative 2 Thymocytes Thymus
     
     Kidney (Urinary System)
             Presumptive Podocytes Podocyte Layer
     
     Yolk Sac (Extraembryonic Tissues)
             Extraembryonic Visceral Endoderm Cells Extraembryonic Visceral Endoderm

    See TMED2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMED2

    SOURCE GeneReport for Unigene cluster: Hs.733403
        SABiosciences Custom PCR Arrays for TMED2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMED2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TMED2 gene from 8/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmed21 , 5 transmembrane emp24 domain trafficking protein 21, 5 91.54(n)1
    99(a)1
      5 (63.65 cM)5
    563341  NM_019770.21  NP_062744.11 
     1245406955 
    chicken
    (Gallus gallus)
    Aves TMED21 transmembrane emp24 domain trafficking protein 2 85.9(n)
    93.03(a)
      416821  NM_001006186.1  NP_001006186.1 
    lizard
    (Anolis carolinensis)
    Reptilia TMED26
    Uncharacterized protein
    91(a)
    1 ↔ 1
    LGb(1771294-1777698)
    African clawed frog
    (Xenopus laevis)
    Amphibia rnp24-prov2 coated vesicle membrane protein 83.95(n)    BC044095.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb18g062 wufb18g06 78.83(n)   321550  BC050165.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CHOp241 CG3564-PA 63.99(n)
    62.31(a)
      31382  NM_131937.3  NP_572165.1 
    worm
    (Caenorhabditis elegans)
    Secernentea sel-91 Protein SEL-9 66.84(n)
    69.27(a)
      179213  NM_072744.3  NP_505145.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes EMP24(YGL200C)4
    EMP241
    Component of the p24 complex; binds to GPI anchor proteins more4
    Emp24p1
    47.72(n)1
    34.52(a)1
      7(123305-122694)4
    8526751, 4  NP_011315.31  NP_011315.14 


    ENSEMBL Gene Tree for TMED2 (if available)
    TreeFam Gene Tree for TMED2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TMED2 gene
    TMED52  TICAM22  TMED12  TMED7-TICAM22  TMED32  TMED72  
    5 SIMAP similar genes for TMED2 using alignment to 3 protein entries:     TMED2_HUMAN (see all proteins):
    RNP24    TMED3    TMED7    TMED9    TMED4

    TMED2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for TMED2
    PGOHUM00000237637 PGOHUM00000262519


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/339 SNPs in TMED2 are shown (see all 339)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs748743841,2
    C,F--124067102(+) ACAGCG/ATATGT 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1157207431,2
    C,F--124067115(+) ATCAAG/ATCTTG 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs118313101,2
    C,F,H--124067132(+) CATGAG/TTGAGG 1 -- us2k14Minor allele frequency- T:0.00NS EA 418
    rs1438246091,2
    --124067173(+) ACCGAA/GTCTGC 1 -- us2k10--------
    rs49307141,2
    C,F,A,H--124067197(-) AGCCCC/TTTCCT 1 -- us2k1 trp321Minor allele frequency- T:0.26NS EA NA WA CSA 2348
    rs73150411,2
    C,F--124067244(+) gataaG/Aaggtg 1 -- us2k1 tfbs31Minor allele frequency- A:0.17WA 118
    rs761008511,2
    C,F--124067280(+) GGAGTG/TTGCCA 1 -- us2k12Minor allele frequency- T:0.07NA EA 240
    rs1810991701,2
    --124067330(+) GGGCTA/GAGGGG 1 -- us2k10--------
    rs1863670381,2
    C--124067454(+) TGCAAC/TAGTTG 1 -- us2k10--------
    rs1481813191,2
    C--124067706(+) TATTGC/TGCTCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TMED2 (124069076 - 124083116 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TMED2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2422416CNV Duplication17116639

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for TMED2:    About MalaCards
    choriocarcinoma    pancreatitis


    TMED2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TMED2
    Human Genome Epidemiology (HuGE) Navigator: TMED2 (1 document)

    Export disorders for TMED2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMED2 gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with TMED2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking. (PubMed id 8663407)1, 2, 3, 9 Blum R....Schulz I. (1996)
    2. Proteinase-activated receptors, nucleotide P2Y recept ors, and I1-opioid receptor-1B are under the control of the type I transmembrane proteins p23 and p24A in post-Golgi trafficking. (PubMed id 21219331)1, 2 Luo W....Reiser G. (2011)
    3. The cargo receptor p24A facilitates calcium sensing r eceptor maturation and stabilization in the early secretory pathway. (PubMed id 20361938)1, 2 Stepanchick A. and Breitwieser G.E. (2010)
    4. The cargo receptors Surf4, endoplasmic reticulum-Golgi intermediate compartment (ERGIC)-53, and p25 are required to maintain the architecture of ERGIC and Golgi. (PubMed id 18287528)1, 2 Mitrovic S.... Hauri H.-P. (2008)
    5. p24A, a type I transmembrane protein, controls ARF1-dependent resensitization of protease-activated receptor-2 by influence on receptor trafficking. (PubMed id 17693410)1, 2 Luo W....Reiser G. (2007)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Oligomeric state and stoichiometry of p24 proteins in the early secretory pathway. (PubMed id 12237308)1, 2 Jenne N.... Wieland F.T. (2002)
    8. Decoding of sorting signals by coatomer through a GTPase switch in the COPI coat complex. (PubMed id 10761932)1, 2 Goldberg J. (2000)
    9. Localization and recycling of gp27 (hp24gamma3): comp lex formation with other p24 family members. (PubMed id 10359607)1, 2 FA1llekrug J....Nilsson T. (1999)
    10. gp25L/emp24/p24 protein family members of the cis-Golgi network bind both COP I and II coatomer. (PubMed id 9472029)1, 2 Dominguez M.... Nilsson T. (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10959 HGNC: 16996 AceView: RNP24 Ensembl:ENSG00000086598 euGenes: HUgn10959
    ECgene: TMED2 H-InvDB: TMED2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMED2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TMED2 gene:
    Search GeneIP for patents involving TMED2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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