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Aliases for TMED2 Gene

Aliases for TMED2 Gene

  • Transmembrane P24 Trafficking Protein 2 2 3 5
  • Transmembrane Emp24 Domain Trafficking Protein 2 2 3
  • P24 Family Protein Beta-1 3 4
  • Membrane Protein P24A 3 4
  • P24beta1 3 4
  • RNP24 3 4
  • P24 3 4
  • Transmembrane Emp24 Domain-Containing Protein 2 3
  • Coated Vesicle Membrane Protein 3
  • P24b1 3
  • P24A 3

External Ids for TMED2 Gene

Previous GeneCards Identifiers for TMED2 Gene

  • GC12P122595
  • GC12P124069
  • GC12P121030

Summaries for TMED2 Gene

GeneCards Summary for TMED2 Gene

TMED2 (Transmembrane P24 Trafficking Protein 2) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Vesicle-mediated transport. An important paralog of this gene is TMED7.

UniProtKB/Swiss-Prot for TMED2 Gene

  • Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase-activating activity of ARFGAP1 towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Facilitates CASR maturation and stabilization in the early secretory pathway and increases CASR plasma membrane targeting. Proposed to be involved in organization of intracellular membranes such as the maintenance of the Golgi apparatus. May also play a role in the biosynthesis of secreted cargo such as eventual processing.

Gene Wiki entry for TMED2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMED2 Gene

Genomics for TMED2 Gene

Regulatory Elements for TMED2 Gene

Enhancers for TMED2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F123600 0.2 ENCODE 22 +17.6 17618 2.6 PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 LOC101927415 EIF2B1 TMED2 DDX55 RPL27P12 ATP6V0A2 CCDC62 GTF2H3 LOC105370046 NCOR2
GH12F123113 1 Ensembl ENCODE 21.7 -468.3 -468329 6.4 PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 ZNF143 PITPNM2 ZCCHC8 LOC101927415 EIF2B1 CDK2AP1 ATP6V0A2 KNTC1 TMED2 RPL27P12 IL31
GH12F123362 1.2 ENCODE 16.2 -219.7 -219706 4.0 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 EIF2B1 CDK2AP1 ZCCHC8 GTF2H3 ENSG00000256092 TMED2 RPL27P12 C12orf65 CCDC62 TCTN2
GH12F123570 1.2 Ensembl ENCODE 13.7 -13.4 -13391 1.5 INSM2 ARID4B ETS1 POLR3A ZNF366 ZNF143 FOS CREM THAP11 ZNF362 LOC101927415 TMED2 C12orf65 EIF2B1 GC12M123581 MIR3908
GH12F123632 0.2 ENCODE 13.6 +49.6 49562 2.3 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 EIF2B1 LOC101927415 ATP6V0A2 TMED2 GTF2H3 NCOR2 ENSG00000235423 DENR ENSG00000279953
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TMED2 on UCSC Golden Path with GeneCards custom track

Promoters for TMED2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001468003 -129 3201 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for TMED2 Gene

Chromosome:
12
Start:
123,584,529 bp from pter
End:
123,598,577 bp from pter
Size:
14,049 bases
Orientation:
Plus strand

Genomic View for TMED2 Gene

Genes around TMED2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMED2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMED2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMED2 Gene

Proteins for TMED2 Gene

  • Protein details for TMED2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15363-TMED2_HUMAN
    Recommended name:
    Transmembrane emp24 domain-containing protein 2
    Protein Accession:
    Q15363

    Protein attributes for TMED2 Gene

    Size:
    201 amino acids
    Molecular mass:
    22761 Da
    Quaternary structure:
    • Monomer and homodimer in the endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment and Golgi. Probably oligomerizes with other members of the EMP24/GP25L family such as TMED7, TMED9 and TMED10. Interacts with TMED10. Associates with the COPI vesicle coat (coatomer); TMED10:TMED2 heterotetramers are proposed to be involved in coatomer association. Interacts (via C-terminus) with COPG1; the interaction involves dimeric TMED2. Interacts with SEC23A; indicative for an association of TMED2 with the COPII vesicle coat. Interacts with ARF1 and ARFGAP1 (By similarity). Interacts with CD59, SEC24A, SEC24B, SEC24C, SEC24D and ATLA1. Interacts with KDELR1; the interaction is decreased by KDEL ligand (By similarity). Interacts with F2RL1; the interaction occurs at the Golgi apparatus. Interacts with CASR (immaturely glycosylated form); the interaction occurs in the endoplasmic reticulum-Golgi intermediate compartment or cis-Golgi. Interacts with F2RL1; the interaction occurs at the Golgi apparatus. Interacts with GORASP1 and GORASP2 (By similarity). Found in a complex composed at least of SURF4, TMED2 and TMED10.
    Miscellaneous:
    • Ectopic expression of TMED2 alone does not result in its proper cis-Golgi network localization. Coexpression of TMED10 is necessary, and coexpression of TMED3 and/or TMED9 is facilitating localization. Down-regulation of TMED10 expression reduces TMED2 protein level.

    Three dimensional structures from OCA and Proteopedia for TMED2 Gene

neXtProt entry for TMED2 Gene

Post-translational modifications for TMED2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMED2 Gene

No data available for DME Specific Peptides for TMED2 Gene

Domains & Families for TMED2 Gene

Gene Families for TMED2 Gene

Protein Domains for TMED2 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q15363

UniProtKB/Swiss-Prot:

TMED2_HUMAN :
  • Contains 1 GOLD domain.
  • Belongs to the EMP24/GP25L family.
Domain:
  • Contains 1 GOLD domain.
Family:
  • Belongs to the EMP24/GP25L family.
genes like me logo Genes that share domains with TMED2: view

Function for TMED2 Gene

Molecular function for TMED2 Gene

UniProtKB/Swiss-Prot Function:
Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase-activating activity of ARFGAP1 towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Facilitates CASR maturation and stabilization in the early secretory pathway and increases CASR plasma membrane targeting. Proposed to be involved in organization of intracellular membranes such as the maintenance of the Golgi apparatus. May also play a role in the biosynthesis of secreted cargo such as eventual processing.

Gene Ontology (GO) - Molecular Function for TMED2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10359607
genes like me logo Genes that share ontologies with TMED2: view
genes like me logo Genes that share phenotypes with TMED2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TMED2

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMED2 Gene

Localization for TMED2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMED2 Gene

Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, COPI-coated vesicle membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Golgi apparatus, Golgi stack membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Note=Cycles between compartments of the early secretatory pathway. {ECO:0000269 PubMed:12237308}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMED2 Gene COMPARTMENTS Subcellular localization image for TMED2 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
extracellular 2
plasma membrane 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TMED2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005783 endoplasmic reticulum IEA,IDA 12237308
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IDA 12237308
GO:0005794 Golgi apparatus IEA,IDA 12237308
genes like me logo Genes that share ontologies with TMED2: view

Pathways & Interactions for TMED2 Gene

genes like me logo Genes that share pathways with TMED2: view

Gene Ontology (GO) - Biological Process for TMED2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0001756 somitogenesis IEA --
GO:0001843 neural tube closure IEA --
GO:0001892 embryonic placenta development IEA --
GO:0001893 maternal placenta development IEA --
genes like me logo Genes that share ontologies with TMED2: view

No data available for SIGNOR curated interactions for TMED2 Gene

Transcripts for TMED2 Gene

Unigene Clusters for TMED2 Gene

Transmembrane emp24 domain trafficking protein 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TMED2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMED2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1:
SP2:
SP3:

Relevant External Links for TMED2 Gene

GeneLoc Exon Structure for
TMED2
ECgene alternative splicing isoforms for
TMED2

Expression for TMED2 Gene

mRNA expression in normal human tissues for TMED2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMED2 Gene



Protein tissue co-expression partners for TMED2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMED2 Gene:

TMED2

SOURCE GeneReport for Unigene cluster for TMED2 Gene:

Hs.733403
genes like me logo Genes that share expression patterns with TMED2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMED2 Gene

Orthologs for TMED2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TMED2 Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia TMED2 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMED2 34
  • 99.17 (n)
mouse
(Mus musculus)
Mammalia Tmed2 16 35
  • 99 (a)
Gm21540 34
  • 91.54 (n)
dog
(Canis familiaris)
Mammalia TMED2 34 35
  • 94.03 (n)
cow
(Bos Taurus)
Mammalia TMED2 34 35
  • 93.03 (n)
rat
(Rattus norvegicus)
Mammalia Tmed2 34
  • 92.21 (n)
oppossum
(Monodelphis domestica)
Mammalia TMED2 35
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMED2 34 35
  • 88.16 (n)
lizard
(Anolis carolinensis)
Reptilia TMED2 35
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmed2 34
  • 85.06 (n)
Str.8778 34
African clawed frog
(Xenopus laevis)
Amphibia rnp24-prov 34
zebrafish
(Danio rerio)
Actinopterygii tmed2 34 35
  • 80.15 (n)
wufb18g06 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11035 34
fruit fly
(Drosophila melanogaster)
Insecta CHOp24 34 35
  • 64.65 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004743 34
  • 63.19 (n)
worm
(Caenorhabditis elegans)
Secernentea sel-9 34 35
  • 67.03 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EMP24 34 35 37
  • 47.86 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F12518g 34
  • 45.52 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5670 35
  • 73 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU08339 34
  • 50.1 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes emp24 34
  • 45.25 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1779 34
Species where no ortholog for TMED2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMED2 Gene

ENSEMBL:
Gene Tree for TMED2 (if available)
TreeFam:
Gene Tree for TMED2 (if available)

Paralogs for TMED2 Gene

Paralogs for TMED2 Gene

(5) SIMAP similar genes for TMED2 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for TMED2 Gene

genes like me logo Genes that share paralogs with TMED2: view

Variants for TMED2 Gene

Sequence variations from dbSNP and Humsavar for TMED2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1049966 -- 123,598,096(+) TGTAT(C/T)TAATA utr-variant-3-prime
rs1056132 -- 123,598,375(+) TTTCT(A/C)TTTGG downstream-variant-500B
rs10582703 -- 123,583,550(+) CAAAC(-/AAAT)TAAAC intron-variant, upstream-variant-2KB
rs10846530 -- 123,595,284(+) ATAGA(C/G)TATAG intron-variant
rs11057302 -- 123,585,466(+) CAGGA(A/G)TTTAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMED2 Gene

Variant ID Type Subtype PubMed ID
dgv523e212 CNV loss 25503493
esv2422416 CNV duplication 17116639
nsv1042181 CNV gain 25217958

Variation tolerance for TMED2 Gene

Residual Variation Intolerance Score: 28.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMED2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMED2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMED2 Gene

Disorders for TMED2 Gene

Relevant External Links for TMED2

Genetic Association Database (GAD)
TMED2
Human Genome Epidemiology (HuGE) Navigator
TMED2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMED2

No disorders were found for TMED2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMED2 Gene

Publications for TMED2 Gene

  1. Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking. (PMID: 8663407) Blum R. … Schulz I. (J. Biol. Chem. 1996) 2 3 4 22 64
  2. Proteinase-activated receptors, nucleotide P2Y receptors, and mu- opioid receptor-1B are under the control of the type I transmembrane proteins p23 and p24A in post-Golgi trafficking. (PMID: 21219331) Luo W. … Reiser G. (J. Neurochem. 2011) 3 4 64
  3. The cargo receptor p24A facilitates calcium sensing receptor maturation and stabilization in the early secretory pathway. (PMID: 20361938) Stepanchick A. … Breitwieser G.E. (Biochem. Biophys. Res. Commun. 2010) 3 4 64
  4. Selective export of human GPI-anchored proteins from the endoplasmic reticulum. (PMID: 20427317) Bonnon C. … Hauri H.P. (J. Cell Sci. 2010) 3 4 64
  5. The cargo receptors Surf4, endoplasmic reticulum-Golgi intermediate compartment (ERGIC)-53, and p25 are required to maintain the architecture of ERGIC and Golgi. (PMID: 18287528) Mitrovic S. … Hauri H.-P. (Mol. Biol. Cell 2008) 3 4 64

Products for TMED2 Gene

Sources for TMED2 Gene

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