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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMED10 Gene

protein-coding   GIFtS: 59
GCID: GC14M075598

Transmembrane Emp24-Like Trafficking Protein 10 (Yeast)

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transmembrane Emp24-Like Trafficking Protein 10 (Yeast)1 2     p232 3
TMP212 3 5     P24 Family Protein Delta-12 3
Transmembrane Protein Tmp212 3     p24delta2 3
21 KDa Transmembrane-Trafficking Protein2 3     p24delta12 3
S31I1252 3     21 KDa Transmembrane Trafficking Protein2
S31III1252 3     P24(DELTA)2
Tmp-21-I2 3     Transmembrane Emp24 Domain-Containing Protein 102

External Ids:    HGNC: 169981   Entrez Gene: 109722   Ensembl: ENSG000001703487   OMIM: 6054065   UniProtKB: P497553   

Export aliases for TMED10 gene to outside databases

Previous GC identifers: GC14M074668 GC14M055766


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TMED10 Gene:
This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane
protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking.
The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase
activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with
early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8. (provided by RefSeq, Jul
2008)

GeneCards Summary for TMED10 Gene: 
TMED10 (transmembrane emp24-like trafficking protein 10 (yeast)) is a protein-coding gene. Diseases associated with TMED10 include alzheimer's disease, and pancreatitis, and among its related super-pathways are Processing of Capped Intron-Containing Pre-mRNA. GO annotations related to this gene include protein binding and protein complex binding.

UniProtKB/Swiss-Prot: TMEDA_HUMAN, P49755
Function: Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to
act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles
and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde
transport involved in the transport of GPI-anchored proteins and proposed to act togther with TMED2 as their
cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like
microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1 (By similarity).
In COPI vesicle-mediated retrograde transport involved in the biogenesis of COPI vesicles and vesicle coat
recruitment. On Golgi membranes, acts as primary receptor for ARF1-GDP which is involved in COPI-vesicle
formation. Increases coatomer-dependent GTPase-activating activity of ARFGAP2. Involved in trafficking of G
protein-coupled receptors (GPCRs). Regulates F2LR1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the
plasma membrane thus contributing to receptor resensitization. Involved in trafficking of amyloid beta A4 protein
and soluble APP-beta release (independent of modulation of gamma-secretase activity). As part of the
presenilin-dependent gamma-secretase complex regulates gamma-cleavages of the amyloid beta A4 protein to yield
amyloid-beta 40 (Abeta40). Involved in organization of the Golgi apparatus

Gene Wiki entry for TMED10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMED10 gene promoter:
         AhR   Bach2   GATA-1   Arnt   MEF-2A   Sox9   aMEF-2   ATF6   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMED10 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMED10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMED10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3   Ensembl cytogenetic band:  14q24.3   HGNC cytogenetic band: 14q24.3

TMED10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMED10 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M075598:  view genomic region     (about GC identifiers)

Start:
75,598,171 bp from pter      End:
75,643,349 bp from pter
Size:
45,179 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TMEDA_HUMAN, P49755 (See protein sequence)
Recommended Name: Transmembrane emp24 domain-containing protein 10 precursor  
Size: 219 amino acids; 24976 Da
Subunit: Predominantly homodimeric and to lesser extent monomeric in endoplasmic reticulum. Homodimer and monomer
in endoplasmic reticulum-Golgi intermediate compartment and cis-Golgi network. Probably oligomerizes with other
members of the EMP24/GP25L family such as TMED2, TMED7 and TMED9. Interacts with TMED2. Associates with the COPI
vesicle coat (coatomer); TMED10:TMED2 heterotetramers are proposed to be involved in coatomer association.
Interacts (via C-terminus) with COPG1; the interaction involves dimeric TMED10. Interacts with ARF1 (GDP-bound);
the interaction probably involves a TMED10 oligomer. Interacts with SEC23A; indicative for an association of
TMED10 with the COPII vesicle coat. Interacts with CD59, SEC24B, SEC24C and SEC24D (By similarity). Interacts
with MPPE1/PGAP5. Interacts with F2LR1. Interacts with KDELR2; the interaction is disrupted by KDELR2 ligand (By
similarity). Found in a complex composed at least of SURF4, TMED2 and TMED10. Associates with the
presenilin-dependent gamma-secretase complex. Interacts with STX17; the interaction is direct
Subcellular location: Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein.
Melanosome. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi
intermediate compartment membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle
membrane; Single-pass type I membrane protein (By similarity). Cell membrane (By similarity). Golgi apparatus,
trans-Golgi network membrane; Single-pass type I membrane protein (By similarity). Note=Identified by mass
spectrometry in melanosome fractions from stage I to stage IV. Cycles between compartments of the early
secretatory pathway
Miscellaneous: Ectopic expression of TMED10 alone does not result in its proper cis-Golgi network localization.
Coexpression of TMED2 is necessary, and coexpression of TMED3 and /or TMED9 is facilitating localization
Sequence caution: Sequence=AAC42003.1; Type=Frameshift; Positions=Several; Sequence=CAD66561.1; Type=Erroneous
initiation; Note=Translation N-terminally shortened;
Secondary accessions: B2R605 Q15602 Q16536 Q86TC2 Q86TS5

Explore the universe of human proteins at neXtProt for TMED10: NX_P49755

Explore proteomics data for TMED10 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P49755

  • TMED10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TMED10 Protein Expression
    REFSEQ proteins: NP_006818.3  
    ENSEMBL proteins: 
     ENSP00000303145   ENSP00000450726  

    Human Recombinant Protein Products for TMED10: 
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    OriGene Protein Over-expression Lysate for TMED10
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    Novus Biologicals TMED10 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TMED10 

    Gene Ontology (GO): 5/16 cellular component terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA12237308
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005793endoplasmic reticulum-Golgi intermediate compartment IDA12237308
    GO:0005794Golgi apparatus IDA12237308
    GO:0005801cis-Golgi network ISS--

    TMED10 for ontologies           About GeneDecksing



    TMED10 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    LSBio Antibodies in human, mouse, rat for TMED10 

    Assay Products for TMED10: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR009038 GOLD

    Graphical View of Domain Structure for InterPro Entry P49755

    ProtoNet protein and cluster: P49755

    1 Blocks protein domain: IPB000348 emp24/gp25L/p24 family

    UniProtKB/Swiss-Prot: TMEDA_HUMAN, P49755
    Domain: The lumenal domain mediates localization to the plasma membrane by partially overriding the ER retention
    by the cytoplasmic domain (By similarity)
    Similarity: Belongs to the EMP24/GP25L family
    Similarity: Contains 1 GOLD domain


    TMED10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TMEDA_HUMAN, P49755
    Function: Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to
    act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles
    and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde
    transport involved in the transport of GPI-anchored proteins and proposed to act togther with TMED2 as their
    cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like
    microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1 (By similarity).
    In COPI vesicle-mediated retrograde transport involved in the biogenesis of COPI vesicles and vesicle coat
    recruitment. On Golgi membranes, acts as primary receptor for ARF1-GDP which is involved in COPI-vesicle
    formation. Increases coatomer-dependent GTPase-activating activity of ARFGAP2. Involved in trafficking of G
    protein-coupled receptors (GPCRs). Regulates F2LR1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the
    plasma membrane thus contributing to receptor resensitization. Involved in trafficking of amyloid beta A4 protein
    and soluble APP-beta release (independent of modulation of gamma-secretase activity). As part of the
    presenilin-dependent gamma-secretase complex regulates gamma-cleavages of the amyloid beta A4 protein to yield
    amyloid-beta 40 (Abeta40). Involved in organization of the Golgi apparatus

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10359607
    GO:0019905syntaxin binding IPI--
    GO:0032403protein complex binding IEA--
         
    TMED10 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for TMED10:
     G0/1 arrest  Increased G1 DNA content  Synthetic lethal with Ras 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tmed10):
     cellular  mortality/aging  no phenotypic analysis 

    TMED10 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tmed10tm1Mjo for TMED10

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TMED10 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TMED10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMED10 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMED10 

    miRNA
    Products:
        
    miRTarBase miRNAs that target TMED10:
    hsa-mir-30a (MIRT005139)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMED10
    8/59 QIAGEN miScript miRNA Assays for microRNAs that regulate TMED10 (see all 59):
    hsa-miR-605 hsa-miR-139-5p hsa-miR-765 hsa-miR-570 hsa-miR-105 hsa-miR-890 hsa-miR-124 hsa-miR-506
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: TMED10 (NM_006827)
    Sino Biological Human cDNA Clone for TMED10
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMED10
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    Sirion Biotech Customized lentivirus for stable overexpression of TMED10 
                         Customized lentivirus expression plasmids for stable overexpression of TMED10 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMED10


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TMED10 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA processing0.46
    2Neuroscience
    Neuroscience

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for TMED10
        Neuroscience

    1 BioSystems Pathway for TMED10
        mRNA processing




    TMED10 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMED10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/136 Interacting proteins for TMED10 (P497551, 3 ENSP000003031454) via UniProtKB, MINT, STRING, and/or I2D (see all 136)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=4 
    HIST1H4BP628053I2D: score=4 
    HIST1H4CP628053I2D: score=4 
    HIST1H4DP628053I2D: score=4 
    HIST1H4EP628053I2D: score=4 
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001101response to acid IEA--
    GO:0001822kidney development IEA--
    GO:0006810transport ----
    GO:0006886intracellular protein transport IDA--
    GO:0006888ER to Golgi vesicle-mediated transport TAS--

    TMED10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMED10 (TMEDA)

    Search CenterWatch for drugs/clinical trials and news about TMED10 / TMEDA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TMED10 gene: 
    NM_006827.5  

    Unigene Cluster for TMED10:

    Transmembrane emp24-like trafficking protein 10 (yeast)
    Hs.74137  [show with all ESTs]
    Unigene Representative Sequence: NM_006827
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000303575(uc010asg.1 uc010tuz.1 uc001xrm.1 uc010ash.1)
    ENST00000556969 ENST00000557670 ENST00000555036 ENST00000555873 ENST00000555085


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMED10
    8/59 QIAGEN miScript miRNA Assays for microRNAs that regulate TMED10 (see all 59):
    hsa-miR-605 hsa-miR-139-5p hsa-miR-765 hsa-miR-570 hsa-miR-105 hsa-miR-890 hsa-miR-124 hsa-miR-506
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
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    OriGene RNAi products in human, mouse, rat for TMED10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMED10
    Clone
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    OriGene clones in human, mouse for TMED10 (see all 7)
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMED10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMED10
    Sirion Biotech Customized lentivirus for stable overexpression of TMED10 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMED10
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMED10

    Additional mRNA sequence: 

    AJ004913.1 AK023615.1 AK056156.1 AK222972.1 AK296800.1 AK302920.1 AK308864.1 AK310371.1 
    AK312384.1 AL832012.2 BC001496.2 BC001825.2 BX248754.1 L40391.1 L40397.1 X97442.1 

    24/40 DOTS entries (see all 40):

    DT.100889318  DT.100060285  DT.449507  DT.100861689  DT.95263752  DT.95168698  DT.100687047  DT.91771143 
    DT.100640193  DT.100687040  DT.97845430  DT.402589  DT.100687041  DT.120791509  DT.92452390  DT.120791514 
    DT.70101341  DT.95263714  DT.100687045  DT.100889322  DT.120791330  DT.100687046  DT.100850264  DT.40120897 

    24/1034 AceView cDNA sequences (see all 1034):

    CF135749 BM853522 BQ181309 BQ010370 BX504823 AI335627 BF437652 AA505378 
    AA725411 BM783806 BQ228628 CB305759 AI673767 CR625338 BM550448 CR606438 
    AI160934 CA841661 AL600921 AA187941 CA868209 AI435885 AW168259 AI453691 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TMED10 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e
    SP1:                                      -     -           -     -                 -                                 
    SP2:                                      -     -           -                                                         
    SP3:                                      -     -           -     -                 -                                 
    SP4:                                      -     -           -     -                                                   
    SP5:                                -     -     -           -     -                 -                                 


    ECgene alternative splicing isoforms for TMED10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMED10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACCCCTGTC
    TMED10 Expression
    About this image


    See TMED10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMED10

    SOURCE GeneReport for Unigene cluster: Hs.74137

    UniProtKB/Swiss-Prot: TMEDA_HUMAN, P49755
    Tissue specificity: Ubiquitous

        SABiosciences Custom PCR Arrays for TMED10
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TMED10 gene from 10/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmed101 , 5 transmembrane emp24-like trafficking protein 10 (yeast)1, 5 89.35(n)1
    92.69(a)1
      12 (39.65 cM)5
    685811  NM_026775.41  NP_081051.11 
     853406145 
    chicken
    (Gallus gallus)
    Aves TMED101 transmembrane emp24-like trafficking protein 10 (yeast) 75.27(n)
    81.69(a)
      423362  NM_001006482.1  NP_001006482.1 
    lizard
    (Anolis carolinensis)
    Reptilia TMED106
    --
    Uncharacterized protein
    77(a)
    67(a)
    1 ↔ 1
    possible ortholog
    1(22514162-22545126)
    GL344183.1(123-7882)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.2542 Xenopus laevis partial mRNA for p24 delta1 putative more 76.93(n)    AJ252243.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.267542 Danio rerio cDNA clone MGC73133 IMAGE4790123, complete more 79.42(n)    BC059496.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta bai1 baiser 57.48(n)
    60.54(a)
      42996  NM_143066.2  NP_651323.3 
    worm
    (Caenorhabditis elegans)
    Secernentea F47G9.11 Protein F47G9.1 59.39(n)
    57.87(a)
      179567  NM_073478.2  NP_505879.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ERV25(YML012W)4
    ERV251
    Protein that forms a heterotrimeric complex with Erp1, more4
    Erv25p1
    47.89(n)1
    41.38(a)1
      13(246116-246751)4
    8549971, 4  NP_013701.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G095801 emp24/gp25L/p24 family/GOLD domain-containing protein 49.51(n)
    36.41(a)
      837485  NM_100830.4  NP_172429.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g07682001 hypothetical protein 49.82(n)
    36.7(a)
      4330850  NM_001054772.1  NP_001048237.1 


    ENSEMBL Gene Tree for TMED10 (if available)
    TreeFam Gene Tree for TMED10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TMED10 gene
    2 SIMAP similar genes for TMED10 using alignment to 2 protein entries:     TMEDA_HUMAN (see all proteins):
    TMED9    TMED4

    TMED10 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for TMED10
    PGOHUM00000238175 PGOHUM00000249817


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/926 SNPs in TMED10 are shown (see all 926)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1754461,2
    C,F,H--75597732(+) TGAGGG/ATTCAT 1 -- ds500119Minor allele frequency- A:0.01NS EA WA NA CSA 1728
    rs1503891071,2
    --75597754(+) GGGGGA/GTGGGG 1 -- ds50010--------
    rs1873544041,2
    --75597840(+) AAACCA/GCAATT 1 -- ds50010--------
    rs1450980761,2
    --75597855(+) TTGTGC/TGAACC 1 -- ds50010--------
    rs1421309951,2
    --75597856(+) TGTGCA/GAACCT 1 -- ds50010--------
    rs1922595051,2
    --75597864(+) CCTAAC/TAGTAA 1 -- ds50010--------
    rs1848200931,2
    --75598112(+) GAAATA/GTGGAA 1 -- ds50010--------
    rs151561,2
    C--75598259(-) AAAGAG/TGCATA 1 -- ut31 trp33Minor allele frequency- T:0.00MN NA 188
    rs1880881421,2
    --75598492(+) TAATAC/TCAATT 1 -- ut310--------
    rs1459882071,2
    C--75598577(+) TGTCAA/GCTCCT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TMED10 (75598171 - 75643349 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TMED10:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2673828CNV Deletion23128226
    nsv85320CNV Loss16902084
    nsv832833CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605406    OMIM disorders: --

    3 diseases for TMED10:    About MalaCards
    alzheimer's disease    pancreatitis    neuronitis


    TMED10 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): TMED10
    Human Genome Epidemiology (HuGE) Navigator: TMED10 (2 documents)

    Export disorders for TMED10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMED10 gene, integrated from 9 sources (see all 62):
    (articles sorted by number of sources associating them with TMED10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking. (PubMed id 8663407)1, 2, 3 Blum R....Schulz I. (1996)
    2. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. (PubMed id 7596406)1, 2, 3 Sherrington R....Holman K. (1995)
    3. Proteinase-activated receptors, nucleotide P2Y recept ors, and I1-opioid receptor-1B are under the control of the type I transmembrane proteins p23 and p24A in post-Golgi trafficking. (PubMed id 21219331)1, 2 Luo W....Reiser G. (2011)
    4. The role of height-associated loci identified in geno me wide association studies in the determination of pediatric stature. (PubMed id 20546612)1, 4 Zhao J....Grant S.F. (2010)
    5. Meta-analysis of genome-wide scans for human adult st ature identifies novel Loci and associations with measures of skeletal frame si ze. (PubMed id 19343178)1, 4 Soranzo N....Deloukas P. (2009)
    6. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (2006)
    7. TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity. (PubMed id 16641999)1, 2 Chen F....Fraser P. (2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10972 HGNC: 16998 AceView: TMP21 Ensembl:ENSG00000170348 euGenes: HUgn10972
    ECgene: TMED10 H-InvDB: TMED10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMED10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TMED10 gene:
    Search GeneIP for patents involving TMED10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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