TMED10 Gene
protein-coding GIFtS: 56
GCID: GC14M075598
|
|
transmembrane emp24-like trafficking protein 10 (yeast)
| |
Aliases
for TMED10 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Emp24-Like Trafficking Protein 10 (Yeast)1 2 | | Tmp-21-I2 3 | | TMP211 2 3 5 | | P231 | | P24(DELTA)1 2 | | P24 Family Protein Delta-12 3 | | Transmembrane Protein Tmp212 3 | | P24delta1 | | 21 KDa Transmembrane-Trafficking Protein2 3 | | P24delta11 | | S31I1252 3 | | 21 KDa Transmembrane Trafficking Protein2 | | S31III1252 3 | | Transmembrane Emp24 Domain-Containing Protein 102 |
Export aliases for TMED10 gene to outside databasesPrevious GC identifers: GC14M074668 GC14M055766 |
Summaries
for TMED10 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TMED10:
This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membraneprotein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. Theprotein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activitywithout affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onsetfamilial Alzheimer's disease. This gene has a pseudogene on chromosome 8. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: TMEDA_HUMAN, P49755Function: Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act ascargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to beinvolved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involvedin the transport of GPI-anchored proteins and proposed to act togther with TMED2 as their cargo receptor; the functionspecifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER.Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1 (By similarity). In COPI vesicle-mediatedretrograde transport involved in the biogenesis of COPI vesicles and vesicle coat recruitment. On Golgi membranes,acts as primary receptor for ARF1-GDP which is involved in COPI-vesicle formation. Increases coatomer-dependentGTPase-activating activity of ARFGAP2. Involved in trafficking of G protein-coupled receptors (GPCRs). RegulatesF2LR1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptorresensitization. Involved in trafficking of amyloid beta A4 protein and soluble APP-beta release (independent ofmodulation of gamma-secretase activity). As part of the presenilin-dependent gamma-secretase complex regulatesgamma-cleavages of the amyloid beta A4 protein to yield amyloid-beta 40 (Abeta40). Involved in organization of theGolgi apparatus
Gene Wiki entry for TMED10
|
Genomic Views
for TMED10 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMED10 gene promoter:
AhR Bach2 GATA-1 Arnt MEF-2A Sox9 aMEF-2 ATF6 RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMED10
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMED10 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q24.3 Ensembl cytogenetic band: 14q24.3 HGNC cytogenetic band: 14q24.3TMED10 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M075598: view genomic region
(about GC identifiers)
Start:
|
75,598,171 bp from pter |
End:
|
75,643,349 bp from pter |
Size:
|
45,179 bases |
Orientation:
|
minus strand |
|
Proteins
for TMED10 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TMEDA_HUMAN, P49755 (See
protein sequence)Recommended Name: Transmembrane emp24 domain-containing protein 10 precursor Size: 219 amino acids; 24976 Da
Subunit: Predominantly homodimeric and to lesser extent monomeric in endoplasmic reticulum. Homodimer and monomer inendoplasmic reticulum-Golgi intermediate compartment and cis-Golgi network. Probably oligomerizes with other membersof the EMP24/GP25L family such as TMED2, TMED7 and TMED9. Interacts with TMED2. Associates with the COPI vesicle coat(coatomer); TMED10:TMED2 heterotetramers are proposed to be involved in coatomer association. Interacts (viaC-terminus) with COPG1; the interaction involves dimeric TMED10. Interacts with ARF1 (GDP-bound); the interactionprobably involves a TMED10 oligomer. Interacts with SEC23A; indicative for an association of TMED10 with the COPIIvesicle coat. Interacts with CD59, SEC24B, SEC24C and SEC24D (By similarity). Interacts with MPPE1/PGAP5. Interactswith F2LR1. Interacts with KDELR2; the interaction is disrupted by KDELR2 ligand (By similarity). Found in a complexcomposed at least of SURF4, TMED2 and TMED10. Associates with the presenilin-dependent gamma-secretase complex
Subcellular location: Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Melanosome.Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediatecompartment membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle membrane;Single-pass type I membrane protein (By similarity). Cell membrane (By similarity). Golgi apparatus, trans-Golginetwork membrane; Single-pass type I membrane protein (By similarity). Note=Identified by mass spectrometry inmelanosome fractions from stage I to stage IV. Cycles between compartments of the early secretatory pathway
Miscellaneous: Ectopic expression of TMED10 alone does not result in its proper cis-Golgi network localization.Coexpression of TMED2 is necessary, and coexpression of TMED3 and /or TMED9 is facilitating localization
Sequence caution: Sequence=AAC42003.1; Type=Frameshift; Positions=Several; Sequence=CAD66561.1; Type=Erroneousinitiation; Note=Translation N-terminally shortened;
Secondary accessions: B2R605 Q15602 Q16536 Q86TC2 Q86TS5Explore the universe of human proteins at neXtProt for TMED10: NX_P49755
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P49755
TMED10 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006818.3
ENSEMBL proteins: ENSP00000303145 ENSP00000450726
Human Recombinant Protein Products for TMED10:
Gene Ontology (GO): 5/16 cellular component terms (GO ID links to tree view) (see all 16): About this table
TMED10 for ontologies About GeneDecksing
TMED10 Antibody Products:
Assay Products for TMED10: |
Protein
Domains /
Families
for TMED10 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMED10 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P49755ProtoNet protein and cluster: P49755 1 Blocks protein family: IPB000348 emp24/gp25L/p24 family
UniProtKB/Swiss-Prot: TMEDA_HUMAN, P49755Domain: The lumenal domain mediates localization to the plasma membrane by partially overriding the ER retention by thecytoplasmic domain (By similarity)Similarity: Belongs to the EMP24/GP25L familySimilarity: Contains 1 GOLD domain |
Function
for TMED10 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: TMEDA_HUMAN, P49755Function: Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act ascargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to beinvolved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involvedin the transport of GPI-anchored proteins and proposed to act togther with TMED2 as their cargo receptor; the functionspecifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER.Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1 (By similarity). In COPI vesicle-mediatedretrograde transport involved in the biogenesis of COPI vesicles and vesicle coat recruitment. On Golgi membranes,acts as primary receptor for ARF1-GDP which is involved in COPI-vesicle formation. Increases coatomer-dependentGTPase-activating activity of ARFGAP2. Involved in trafficking of G protein-coupled receptors (GPCRs). RegulatesF2LR1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptorresensitization. Involved in trafficking of amyloid beta A4 protein and soluble APP-beta release (independent ofmodulation of gamma-secretase activity). As part of the presenilin-dependent gamma-secretase complex regulatesgamma-cleavages of the amyloid beta A4 protein to yield amyloid-beta 40 (Abeta40). Involved in organization of theGolgi apparatus Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- | | GO:0032403 | protein complex binding |
IEA | -- |
TMED10 for ontologies About GeneDecksing
Phenotypes:
3 GenomeRNAi human phenotypes for TMED10:
3 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Tmed10):
TMED10 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Tmed10tm1Mjo for TMED10
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMED10 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMED10
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TMED10 (NM_006827) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMED10 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMED10 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMED10 |
|
Pathways & Interactions
for TMED10 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Neuroscience | | | 2 | mRNA Splicing - Major Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Cell Signaling Technology (CST) Pathway for TMED10
1  BioSystems Pathway for TMED10
TMED10 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMED10
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/136 Interacting proteins for TMED10 (P497551, 3 ENSP000003031454) via UniProtKB, MINT, STRING, and/or I2D (see all 136)About this table
Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16): About this table
TMED10 for ontologies About GeneDecksing
|
Drugs & Compounds
for TMED10 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMED10
Search CenterWatch for drugs/clinical trials and news about TMED10 / TMEDA
|
Transcripts
for TMED10 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMED10 gene: NM_006827.5 Unigene Cluster for TMED10: Transmembrane emp24-like trafficking protein 10 (yeast) Hs.74137 [show with all ESTs]Unigene Representative Sequence: NM_0068276 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000303575(uc010asg.1 uc010tuz.1 uc001xrm.1 uc010ash.1)
ENST00000556969 ENST00000557670 ENST00000555036 ENST00000555873 ENST00000555085
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMED10 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMED10
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TMED10 (NM_006827) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMED10 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMED10 |
Additional cDNA sequence: AJ004913.1 AK023615.1 AK056156.1 AK222972.1 AK296800.1 AK302920.1 AK308864.1 AK310371.1 AK312384.1 AL832012.2 BC001496.2 BC001825.2 BX248754.1 L40391.1 L40397.1 X97442.1 24/39 DOTS entries (see all 39): DT.100060285 DT.100889318 DT.449507 DT.100861689 DT.95263752 DT.95168698 DT.91771143 DT.100687047 DT.100640193 DT.97845430 DT.100687040 DT.402589 DT.100687041 DT.120791514 DT.70101341 DT.95263714 DT.100687045 DT.100889322 DT.120791330 DT.120791509 DT.92452390 DT.100687046 DT.100850264 DT.40120897 24/1034 AceView cDNA sequences (see all 1034): AL701963 AI287337 BG742353 AA187941 AA772169 AW516168 BQ130537 CA416399 BM755864 CF136427 AA339735 BM761807 AI078866 BU627963 AA471009 BC001825 BE748353 CB114839 AI371358 AI453691 AI148319 BX450693 BM745505 CA395590
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TMED10 (see all 8) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e |
|---|
|
| SP1: | | | | | | | | | | | | | - | | - | | | | - | | - | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | - | | | | - | | - | | | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | - | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | - | | - | | | | - | | - | | | | | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for TMED10
|
Expression
for TMED10 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMED10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACCCCTGTC
About this image
See TMED10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMED10
SOURCE GeneReport for Unigene cluster: Hs.74137
UniProtKB/Swiss-Prot: TMEDA_HUMAN, P49755Tissue specificity: Ubiquitous
SABiosciences Custom PCR Arrays for TMED10
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMED10
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMED10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMED10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMED10 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMED10 |
Orthologs
for TMED10 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TMED10 gene from 9/32 species (see all 32) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
TMED101 |
transmembrane emp24-like trafficking protein 10 (yeast) |
75.27(n)
81.69(a) |
|
423362 NM_001006482.1 NP_001006482.1 |
lizard
(Anolis carolinensis) |
Reptilia |
TMED106-- |
-- |
75(a)65(a) |
1 ↔ 1possible ortholog |
1(22514141-22540781) GL344183.1(3542-7882) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.2542 |
Xenopus laevis partial mRNA for p24 delta1 putative more |
76.93(n) |
|
AJ252243.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.267542 |
Danio rerio cDNA clone MGC73133 IMAGE4790123, complete more |
79.42(n) |
|
BC059496.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
bai1 |
baiser |
57.48(n)
60.54(a) |
|
42996 NM_143066.2 NP_651323.3 |
worm
(Caenorhabditis elegans) |
Secernentea |
F47G9.11 |
Protein F47G9.1 |
59.39(n)
57.87(a) |
|
179567 NM_073478.2 NP_505879.1 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
ERV25(YML012W)4
ERV251 |
Protein that forms a heterotrimeric complex with Erp1, more4
Erv25p1 |
47.89(n)1
41.38(a)1 |
|
13(246116-246751)4
8549971, 4 NP_013701.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G095801 |
emp24/gp25L/p24 family/GOLD domain-containing protein |
49.51(n)
36.41(a) |
|
837485 NM_100830.4 NP_172429.1 |
rice
(Oryza sativa) |
Liliopsida |
Os02g07682001 |
hypothetical protein |
49.82(n)
36.7(a) |
|
4330850 NM_001054772.1 NP_001048237.1 |
ENSEMBL Gene Tree for TMED10 (if available)
TreeFam Gene Tree for TMED10 (if available) |
Paralogs
for TMED10 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TMED10 gene
2 SIMAP similar genes for TMED10 using alignment to 2 protein entries: TMEDA_HUMAN (see all proteins):TMED9 TMED4
TMED10 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for TMED10
PGOHUM00000238175 PGOHUM00000249817
|
Genomic Variants
for TMED10 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMED10 (75598171 - 75643349 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TMED10
1 Indel: 11742 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for TMED10 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TMED10 for disorders About GeneDecksing
OMIM gene information: 605406
OMIM disorders: --
3  diseases for TMED10: About MalaCardsearly-onset familial alzheimer disease alzheimer's disease pancreatitis
Human Genome Epidemiology (HuGE) Navigator: TMED10 (2 documents)
Export disorders for TMED10 gene to outside databases
|
Publications
for TMED10 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMED10 gene, integrated from 9 sources (see all 56):
(articles sorted by number of sources associating them with TMED10) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking. (PubMed id 8663407)1, 2, 3 Blum R....Schulz I. (1996)
- Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. (PubMed id 7596406)1, 2, 3 Sherrington R....Holman K. (1995)
- Proteinase-activated receptors, nucleotide P2Y recept ors, and I1-opioid receptor-1B are under the control of the type I transmembrane proteins p23 and p24A in post-Golgi trafficking. (PubMed id 21219331)1, 2 Luo W....Reiser G. (2011)
- Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (2006)
- TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity. (PubMed id 16641999)1, 2 Chen F....Fraser P. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (2003)
- Oligomeric state and stoichiometry of p24 proteins in the early secretory pathway. (PubMed id 12237308)1, 2 Jenne N.... Wieland F.T. (2002)
- Recruitment to Golgi membranes of ADP-ribosylation factor 1 is mediated by the cytoplasmic domain of p23. (PubMed id 11726511)1, 2 Gommel D.U....Wieland F.T. (2001)
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External Searches for TMED10 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing TMED10 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing TMED10 gene
(According to HUGE)
About This Section
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Specialized Databases showing TMED10 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMED10 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for TMED10 gene:
Search GeneIP for patents involving TMED10
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for TMED10 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | |  | OriGene Antibodies for TMED10 | | OriGene shRNA RFP for TMED10 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMED10 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMED10 | | | OriGene Protein Over-expression Lysate for TMED10 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMED10 | | OriGene 3'-UTR Clone for TMED10 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMED10 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMED10 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TMED10 | | OriGene Custom Protein Services for TMED10 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMED10 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMED10 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMED10 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMED10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMED10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMED10 |
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| | Antibodies & Assays for TMED10 |
| | | | Search Tocris compounds for TMED10 |
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 | | | TMED10 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMED10 |
|  |  |  |  | | | | ThermoFisher Antibody for TMED10 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMED10 |
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