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Aliases for TMED10 Gene

Aliases for TMED10 Gene

  • Transmembrane Emp24-Like Trafficking Protein 10 (Yeast) 2 3
  • TMP21 3 4 6
  • 21 KDa Transmembrane-Trafficking Protein 3 4
  • Transmembrane Protein Tmp21 3 4
  • P24 Family Protein Delta-1 3 4
  • S31III125 3 4
  • P24delta1 3 4
  • Tmp-21-I 3 4
  • P24delta 3 4
  • S31I125 3 4
  • P23 3 4
  • Transmembrane Emp24 Domain-Containing Protein 10 3
  • 21 KDa Transmembrane Trafficking Protein 3
  • P24(DELTA) 3

External Ids for TMED10 Gene

Summaries for TMED10 Gene

Entrez Gene Summary for TMED10 Gene

  • This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8. [provided by RefSeq, Jul 2008]

GeneCards Summary for TMED10 Gene

TMED10 (Transmembrane Emp24-Like Trafficking Protein 10 (Yeast)) is a Protein Coding gene. Among its related pathways are Neuroscience and mRNA Splicing - Major Pathway. GO annotations related to this gene include protein complex binding and syntaxin binding.

UniProtKB/Swiss-Prot for TMED10 Gene

  • Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1 (By similarity). In COPI vesicle-mediated retrograde transport involved in the biogenesis of COPI vesicles and vesicle coat recruitment. On Golgi membranes, acts as primary receptor for ARF1-GDP which is involved in COPI-vesicle formation. Increases coatomer-dependent GTPase-activating activity of ARFGAP2. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2LR1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Involved in trafficking of amyloid beta A4 protein and soluble APP-beta release (independent of modulation of gamma-secretase activity). As part of the presenilin-dependent gamma-secretase complex regulates gamma-cleavages of the amyloid beta A4 protein to yield amyloid-beta 40 (Abeta40). Involved in organization of the Golgi apparatus.

Gene Wiki entry for TMED10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMED10 Gene

Genomics for TMED10 Gene

Genomic Location for TMED10 Gene

Start:
75,131,468 bp from pter
End:
75,176,646 bp from pter
Size:
45,179 bases
Orientation:
Minus strand

Genomic View for TMED10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMED10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMED10 Gene

Regulatory Elements for TMED10 Gene

Proteins for TMED10 Gene

  • Protein details for TMED10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49755-TMEDA_HUMAN
    Recommended name:
    Transmembrane emp24 domain-containing protein 10
    Protein Accession:
    P49755
    Secondary Accessions:
    • B2R605
    • Q15602
    • Q16536
    • Q86TC2
    • Q86TS5

    Protein attributes for TMED10 Gene

    Size:
    219 amino acids
    Molecular mass:
    24976 Da
    Quaternary structure:
    • Predominantly homodimeric and to lesser extent monomeric in endoplasmic reticulum. Homodimer and monomer in endoplasmic reticulum-Golgi intermediate compartment and cis-Golgi network. Probably oligomerizes with other members of the EMP24/GP25L family such as TMED2, TMED7 and TMED9. Interacts with TMED2. Associates with the COPI vesicle coat (coatomer); TMED10:TMED2 heterotetramers are proposed to be involved in coatomer association. Interacts (via C-terminus) with COPG1; the interaction involves dimeric TMED10. Interacts with ARF1 (GDP-bound); the interaction probably involves a TMED10 oligomer. Interacts with SEC23A; indicative for an association of TMED10 with the COPII vesicle coat. Interacts with CD59, SEC24B, SEC24C and SEC24D (By similarity). Interacts with MPPE1/PGAP5. Interacts with F2LR1. Interacts with KDELR2; the interaction is disrupted by KDELR2 ligand (By similarity). Found in a complex composed at least of SURF4, TMED2 and TMED10. Associates with the presenilin-dependent gamma-secretase complex. Interacts with STX17; the interaction is direct.
    Miscellaneous:
    • Ectopic expression of TMED10 alone does not result in its proper cis-Golgi network localization. Coexpression of TMED2 is necessary, and coexpression of TMED3 and /or TMED9 is facilitating localization
    SequenceCaution:
    • Sequence=AAC42003.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=CAD66561.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for TMED10 Gene

Proteomics data for TMED10 Gene at MOPED

Post-translational modifications for TMED10 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys75, Lys87, Lys127, Lys133, Lys140, and Lys145
  • Glycosylation at Thr55, Thr77, and Asn179

Other Protein References for TMED10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMED10 Gene

Domains for TMED10 Gene

Protein Domains for TMED10 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

TMEDA_HUMAN
Domain:
  • The lumenal domain mediates localization to the plasma membrane by partially overriding the ER retention by the cytoplasmic domain.:
    • P49755
  • Contains 1 GOLD domain.:
    • P49755
Family:
  • Belongs to the EMP24/GP25L family.:
    • P49755
genes like me logo Genes that share domains with TMED10: view

No data available for Gene Families for TMED10 Gene

Function for TMED10 Gene

Molecular function for TMED10 Gene

UniProtKB/Swiss-Prot Function: Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1 (By similarity). In COPI vesicle-mediated retrograde transport involved in the biogenesis of COPI vesicles and vesicle coat recruitment. On Golgi membranes, acts as primary receptor for ARF1-GDP which is involved in COPI-vesicle formation. Increases coatomer-dependent GTPase-activating activity of ARFGAP2. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2LR1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Involved in trafficking of amyloid beta A4 protein and soluble APP-beta release (independent of modulation of gamma-secretase activity). As part of the presenilin-dependent gamma-secretase complex regulates gamma-cleavages of the amyloid beta A4 protein to yield amyloid-beta 40 (Abeta40). Involved in organization of the Golgi apparatus.

Gene Ontology (GO) - Molecular Function for TMED10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10359607
GO:0019905 syntaxin binding IPI 21545355
GO:0032403 protein complex binding IEA --
genes like me logo Genes that share ontologies with TMED10: view

Phenotypes for TMED10 Gene

genes like me logo Genes that share phenotypes with TMED10: view

Animal Models for TMED10 Gene

MGI Knock Outs for TMED10:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TMED10 Gene

Localization for TMED10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMED10 Gene

Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Melanosome. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type I membrane protein. Cell membrane. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Cycles between compartments of the early secretatory pathway.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMED10 Gene COMPARTMENTS Subcellular localization image for TMED10 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 5
golgi apparatus 4
extracellular 2
lysosome 1

Gene Ontology (GO) - Cellular Components for TMED10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS 10761932
GO:0005783 endoplasmic reticulum IDA 12237308
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IDA 12237308
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with TMED10: view

Pathways for TMED10 Gene

SuperPathways for TMED10 Gene

genes like me logo Genes that share pathways with TMED10: view

Pathways by source for TMED10 Gene

1 Cell Signaling Technology pathway for TMED10 Gene
1 BioSystems pathway for TMED10 Gene

Gene Ontology (GO) - Biological Process for TMED10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001822 kidney development IEA --
GO:0006810 transport --
GO:0006886 intracellular protein transport IDA 20427317
GO:0006888 ER to Golgi vesicle-mediated transport TAS 20427317
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER ISS --
genes like me logo Genes that share ontologies with TMED10: view

Transcripts for TMED10 Gene

Unigene Clusters for TMED10 Gene

Transmembrane emp24-like trafficking protein 10 (yeast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMED10 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e
SP1: - - - - -
SP2: - - -
SP3: - - - - -
SP4: - - - -
SP5: - - - - - -
SP6: - - - -
SP7: - -
SP8: - -

Relevant External Links for TMED10 Gene

GeneLoc Exon Structure for
TMED10
ECgene alternative splicing isoforms for
TMED10

Expression for TMED10 Gene

mRNA expression in normal human tissues for TMED10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMED10 Gene

SOURCE GeneReport for Unigene cluster for TMED10 Gene Hs.74137

mRNA Expression by UniProt/SwissProt for TMED10 Gene

P49755-TMEDA_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with TMED10: view

Orthologs for TMED10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TMED10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMED10 36
  • 99.54 (n)
  • 99.54 (a)
TMED10 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMED10 36
  • 91.48 (n)
  • 94.98 (a)
TMED10 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMED10 36
  • 92.24 (n)
  • 94.98 (a)
TMED10 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmed10 36
  • 89.35 (n)
  • 92.69 (a)
Tmed10 16
Tmed10 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMED10 37
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMED10 37
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmed10 36
  • 88.74 (n)
  • 93.15 (a)
chicken
(Gallus gallus)
Aves TMED10 36
  • 78.66 (n)
  • 87.3 (a)
TMED10 37
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMED10 37
  • 77 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.254 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC549012 36
  • 73.23 (n)
  • 86.17 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.26754 36
tmed10 36
  • 77.36 (n)
  • 89.3 (a)
tmed10 37
  • 82 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001064 36
  • 59.42 (n)
  • 62.5 (a)
fruit fly
(Drosophila melanogaster)
Insecta bai 36
  • 57.3 (n)
  • 60.54 (a)
bai 37
  • 55 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F47G9.1 36
  • 60.18 (n)
  • 59.46 (a)
F47G9.1 37
  • 55 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERV25 36
  • 48.28 (n)
  • 43.1 (a)
ERV25 37
  • 36 (a)
OneToOne
ERV25 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B00935g 36
  • 48.23 (n)
  • 42.02 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G21900 36
  • 48.23 (n)
  • 36.17 (a)
rice
(Oryza sativa)
Liliopsida Os06g0210100 36
  • 50.9 (n)
  • 39.25 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01342 36
  • 49.72 (n)
  • 40.22 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes erv25 36
  • 45.92 (n)
  • 35.11 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8367 37
  • 77 (a)
OneToOne
Species with no ortholog for TMED10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMED10 Gene

ENSEMBL:
Gene Tree for TMED10 (if available)
TreeFam:
Gene Tree for TMED10 (if available)

Paralogs for TMED10 Gene

Selected SIMAP similar genes for TMED10 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for TMED10 Gene

genes like me logo Genes that share paralogs with TMED10: view

No data available for Paralogs for TMED10 Gene

Variants for TMED10 Gene

Sequence variations from dbSNP and Humsavar for TMED10 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs4649 -- 75,134,960(-) ATGTT(C/T)TGTCT reference, synonymous-codon
rs4929 - 75,176,389(-) CCAGT(A/C)TGGGG missense, reference
rs12527 -- 75,134,585(-) TGTCC(C/T)GGGTT utr-variant-3-prime
rs12528 -- 75,134,582(-) CCTGG(G/T)TTCCC utr-variant-3-prime
rs13099 -- 75,132,452(+) ACTTG(A/G)ATGCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TMED10 Gene

Variant ID Type Subtype PubMed ID
nsv832833 CNV Gain 17160897
esv2673828 CNV Deletion 23128226
nsv85320 CNV Loss 16902084

Relevant External Links for TMED10 Gene

HapMap Linkage Disequilibrium report
TMED10

Disorders for TMED10 Gene

Relevant External Links for TMED10

Genetic Association Database (GAD)
TMED10
Human Genome Epidemiology (HuGE) Navigator
TMED10
genes like me logo Genes that share disorders with TMED10: view

No data available for UniProtKB/Swiss-Prot for TMED10 Gene

Publications for TMED10 Gene

  1. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. (PMID: 7596406) Sherrington R. … St George-Hyslop P.H. (Nature 1995) 2 3 4
  2. Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking. (PMID: 8663407) Blum R. … Schulz I. (J. Biol. Chem. 1996) 2 3 4
  3. gp25L/emp24/p24 protein family members of the cis-Golgi network bind both COP I and II coatomer. (PMID: 9472029) Dominguez M. … Nilsson T. (J. Cell Biol. 1998) 3 4
  4. Localization and recycling of gp27 (hp24gamma3): complex formation with other p24 family members. (PMID: 10359607) Fullekrug J. … Nilsson T. (Mol. Biol. Cell 1999) 3 4
  5. A comparative study of rat and human Tmp21 (p23) reveals the pseudogene-like features of human Tmp21-II. (PMID: 10376215) Hoerer J. … Schulz I. (DNA Seq. 1999) 3 4

Products for TMED10 Gene

Sources for TMED10 Gene

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