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TMED10 Gene

protein-coding   GIFtS: 61
GCID: GC14M075598

Transmembrane Emp24-Like Trafficking Protein 10 (Yeast)

  Search for TMED10
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Emp24-Like Trafficking Protein 10 (Yeast)1 2     p232 3
TMP212 3 5     P24 Family Protein Delta-12 3
Transmembrane Protein Tmp212 3     p24delta2 3
21 KDa Transmembrane-Trafficking Protein2 3     p24delta12 3
S31I1252 3     21 KDa Transmembrane Trafficking Protein2
S31III1252 3     P24(DELTA)2
Tmp-21-I2 3     Transmembrane Emp24 Domain-Containing Protein 102

External Ids:    HGNC: 169981   Entrez Gene: 109722   Ensembl: ENSG000001703487   OMIM: 6054065   UniProtKB: P497553   

Export aliases for TMED10 gene to outside databases

Previous GC identifers: GC14M074668 GC14M055766


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TMED10 Gene:
This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane
protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking.
The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase
activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with
early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8. (provided by RefSeq, Jul
2008)

GeneCards Summary for TMED10 Gene:
TMED10 (transmembrane emp24-like trafficking protein 10 (yeast)) is a protein-coding gene. GO annotations related to this gene include protein complex binding and syntaxin binding.

UniProtKB/Swiss-Prot: TMEDA_HUMAN, P49755
Function: Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to
act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles
and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde
transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED2 as their
cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like
microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1 (By similarity).
In COPI vesicle-mediated retrograde transport involved in the biogenesis of COPI vesicles and vesicle coat
recruitment. On Golgi membranes, acts as primary receptor for ARF1-GDP which is involved in COPI-vesicle
formation. Increases coatomer-dependent GTPase-activating activity of ARFGAP2. Involved in trafficking of G
protein-coupled receptors (GPCRs). Regulates F2LR1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the
plasma membrane thus contributing to receptor resensitization. Involved in trafficking of amyloid beta A4 protein
and soluble APP-beta release (independent of modulation of gamma-secretase activity). As part of the
presenilin-dependent gamma-secretase complex regulates gamma-cleavages of the amyloid beta A4 protein to yield
amyloid-beta 40 (Abeta40). Involved in organization of the Golgi apparatus

Gene Wiki entry for TMED10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMED10 gene promoter:
         AhR   Bach2   GATA-1   Arnt   MEF-2A   Sox9   aMEF-2   ATF6   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMED10 promoter sequence
   Search Chromatin IP Primers for TMED10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMED10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3   Ensembl cytogenetic band:  14q24.3   HGNC cytogenetic band: 14q24.3

TMED10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMED10 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M075598:  view genomic region     (about GC identifiers)

Start:
75,598,171 bp from pter      End:
75,643,349 bp from pter
Size:
45,179 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TMEDA_HUMAN, P49755 (See protein sequence)
Recommended Name: Transmembrane emp24 domain-containing protein 10 precursor  
Size: 219 amino acids; 24976 Da
Subunit: Predominantly homodimeric and to lesser extent monomeric in endoplasmic reticulum. Homodimer and monomer
in endoplasmic reticulum-Golgi intermediate compartment and cis-Golgi network. Probably oligomerizes with other
members of the EMP24/GP25L family such as TMED2, TMED7 and TMED9. Interacts with TMED2. Associates with the COPI
vesicle coat (coatomer); TMED10:TMED2 heterotetramers are proposed to be involved in coatomer association.
Interacts (via C-terminus) with COPG1; the interaction involves dimeric TMED10. Interacts with ARF1 (GDP-bound);
the interaction probably involves a TMED10 oligomer. Interacts with SEC23A; indicative for an association of
TMED10 with the COPII vesicle coat. Interacts with CD59, SEC24B, SEC24C and SEC24D (By similarity). Interacts
with MPPE1/PGAP5. Interacts with F2LR1. Interacts with KDELR2; the interaction is disrupted by KDELR2 ligand (By
similarity). Found in a complex composed at least of SURF4, TMED2 and TMED10. Associates with the
presenilin-dependent gamma-secretase complex. Interacts with STX17; the interaction is direct
Miscellaneous: Ectopic expression of TMED10 alone does not result in its proper cis-Golgi network localization.
Coexpression of TMED2 is necessary, and coexpression of TMED3 and /or TMED9 is facilitating localization
Sequence caution: Sequence=AAC42003.1; Type=Frameshift; Positions=Several; Sequence=CAD66561.1; Type=Erroneous
initiation; Note=Translation N-terminally shortened;
Secondary accessions: B2R605 Q15602 Q16536 Q86TC2 Q86TS5

Explore the universe of human proteins at neXtProt for TMED10: NX_P49755

Explore proteomics data for TMED10 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys75, Lys87, Lys127, Lys133, Lys140, Lys145
  • Glycosylation2 at Thr55, Thr77, Asn179
  • Modification sites at PhosphoSitePlus

  • See TMED10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006818.3  
    ENSEMBL proteins: 
     ENSP00000303145   ENSP00000450726  

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    Search eBioscience for ELISAs for TMED10 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR009038 GOLD

    Graphical View of Domain Structure for InterPro Entry P49755

    ProtoNet protein and cluster: P49755

    1 Blocks protein domain: IPB000348 emp24/gp25L/p24 family

    UniProtKB/Swiss-Prot: TMEDA_HUMAN, P49755
    Domain: The lumenal domain mediates localization to the plasma membrane by partially overriding the ER retention
    by the cytoplasmic domain (By similarity)
    Similarity: Belongs to the EMP24/GP25L family
    Similarity: Contains 1 GOLD domain


    Find genes that share domains with TMED10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TMEDA_HUMAN, P49755
    Function: Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to
    act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles
    and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde
    transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED2 as their
    cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like
    microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1 (By similarity).
    In COPI vesicle-mediated retrograde transport involved in the biogenesis of COPI vesicles and vesicle coat
    recruitment. On Golgi membranes, acts as primary receptor for ARF1-GDP which is involved in COPI-vesicle
    formation. Increases coatomer-dependent GTPase-activating activity of ARFGAP2. Involved in trafficking of G
    protein-coupled receptors (GPCRs). Regulates F2LR1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the
    plasma membrane thus contributing to receptor resensitization. Involved in trafficking of amyloid beta A4 protein
    and soluble APP-beta release (independent of modulation of gamma-secretase activity). As part of the
    presenilin-dependent gamma-secretase complex regulates gamma-cleavages of the amyloid beta A4 protein to yield
    amyloid-beta 40 (Abeta40). Involved in organization of the Golgi apparatus

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10359607
    GO:0019905syntaxin binding IPI--
    GO:0032403protein complex binding IEA--
         
    Find genes that share ontologies with TMED10           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for TMED10:
     G0/1 arrest  Increased G1 DNA content  Synthetic lethal with Ras 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tmed10):
     cellular  mortality/aging  no phenotypic analysis 

    Find genes that share phenotypes with TMED10           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Tmed10tm1Mjo for TMED10

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMED10
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TMED10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMED10
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMED10

    miRNA
    Products:
        
    miRTarBase miRNAs that target TMED10:
    hsa-mir-192-5p (MIRT026497), hsa-mir-7-5p (MIRT025755), hsa-mir-215-5p (MIRT024306), hsa-mir-124-3p (MIRT022632), hsa-mir-30a-5p (MIRT005139), hsa-mir-17-5p (MIRT050886)

    Block miRNA regulation of human, mouse, rat TMED10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TMED10 (see all 59):
    hsa-miR-605 hsa-miR-139-5p hsa-miR-765 hsa-miR-570 hsa-miR-105 hsa-miR-890 hsa-miR-124 hsa-miR-506
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TMED10

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    GenScript: all cDNA clones in your preferred vector: TMED10 (NM_006827)
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMED10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TMEDA_HUMAN, P49755: Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein.
    Melanosome. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi
    intermediate compartment membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle
    membrane; Single-pass type I membrane protein (By similarity). Cell membrane (By similarity). Golgi apparatus,
    trans-Golgi network membrane; Single-pass type I membrane protein (By similarity). Note=Identified by mass
    spectrometry in melanosome fractions from stage I to stage IV. Cycles between compartments of the early
    secretatory pathway
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane5
    golgi apparatus4
    extracellular2
    lysosome1

    Gene Ontology (GO): Selected cellular component terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS10761932
    GO:0005783endoplasmic reticulum IDA12237308
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005793endoplasmic reticulum-Golgi intermediate compartment IDA12237308
    GO:0005794Golgi apparatus IDA--

    Find genes that share ontologies with TMED10           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TMED10 About    
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA processing0.44
    2Neuroscience
    Neuroscience


    Find genes that share SuperPaths with TMED10           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for TMED10
        Neuroscience

    1 BioSystems Pathway for TMED10
        mRNA processing



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMED10
    Interactions:

        Search GeneGlobe Interaction Network for TMED10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TMED10 (P497551, 3 ENSP000003031454) via UniProtKB, MINT, STRING, and/or I2D (see all 171)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4HP628053, ENSP000002893524I2D: score=4 STRING: ENSP00000289352
    HIST1H4FP628053, ENSP000003669744I2D: score=4 STRING: ENSP00000366974
    HIST1H4AP628053I2D: score=4 
    HIST1H4BP628053I2D: score=4 
    HIST1H4CP628053I2D: score=4 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001101response to acid IEA--
    GO:0001822kidney development IEA--
    GO:0006810transport ----
    GO:0006886intracellular protein transport IDA--
    GO:0006888ER to Golgi vesicle-mediated transport TAS--

    Find genes that share ontologies with TMED10           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMED10 (TMEDA)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TMED10 gene: 
    NM_006827.5  

    Unigene Cluster for TMED10:

    Transmembrane emp24-like trafficking protein 10 (yeast)
    Hs.74137  [show with all ESTs]
    Unigene Representative Sequence: NM_006827
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000303575(uc010asg.1 uc010tuz.1 uc001xrm.1 uc010ash.1)
    ENST00000556969 ENST00000557670 ENST00000555036 ENST00000555873 ENST00000555085

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TMED10 (see all 59):
    hsa-miR-605 hsa-miR-139-5p hsa-miR-765 hsa-miR-570 hsa-miR-105 hsa-miR-890 hsa-miR-124 hsa-miR-506
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat TMED10
      QuantiFast Probe-based Assays in human, mouse, rat TMED10

    Additional mRNA sequence: 

    AJ004913.1 AK023615.1 AK056156.1 AK222972.1 AK296800.1 AK302920.1 AK308864.1 AK310371.1 
    AK312384.1 AL832012.2 BC001496.2 BC001825.2 BX248754.1 L40391.1 L40397.1 X97442.1 

    Selected DOTS entries (see all 40):

    DT.100889318  DT.100060285  DT.449507  DT.100861689  DT.95263752  DT.95168698  DT.100687047  DT.91771143 
    DT.100640193  DT.100687040  DT.97845430  DT.402589  DT.100687041  DT.120791509  DT.92452390  DT.120791514 
    DT.70101341  DT.95263714  DT.100687045  DT.100889322  DT.120791330  DT.100687046  DT.100850264  DT.40120897 

    Selected AceView cDNA sequences (see all 1034):

    AV653759 F11123 BU539722 BP339996 AA128047 AA505378 CA841661 AI863902 
    CR606438 BM550448 CF135749 AA877868 AA187941 CB216803 AA148741 BP355945 
    BF061162 BQ181309 T32721 BU735817 AI801493 AA725411 AI114482 BU631411 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TMED10 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e
    SP1:                                      -     -           -     -                 -                                 
    SP2:                                      -     -           -                                                         
    SP3:                                      -     -           -     -                 -                                 
    SP4:                                      -     -           -     -                                                   
    SP5:                                -     -     -           -     -                 -                                 


    ECgene alternative splicing isoforms for TMED10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMED10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACCCCTGTC
    TMED10 Expression
    About this image


    TMED10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    TMED10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMED10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.74137

    UniProtKB/Swiss-Prot: TMEDA_HUMAN, P49755
    Tissue specificity: Ubiquitous

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TMED10 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmed101 , 5 transmembrane emp24-like trafficking protein 10 (yeast)1, 5 89.35(n)1
    92.69(a)1
      12 (39.65 cM)5
    685811  NM_026775.41  NP_081051.11 
     853406145 
    chicken
    (Gallus gallus)
    Aves TMED101 transmembrane emp24-like trafficking protein 10 (yeast) 78.66(n)
    87.3(a)
      423362  NM_001006482.1  NP_001006482.1 
    lizard
    (Anolis carolinensis)
    Reptilia TMED106
    transmembrane emp24-like trafficking protein 10 (y...
    77(a)
    1 ↔ 1
    1(22514162-22545126)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.2542 Xenopus laevis partial mRNA for p24 delta1 putative more 76.93(n)    AJ252243.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.267542 Danio rerio cDNA clone MGC73133 IMAGE4790123, complete more 79.42(n)    BC059496.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta bai1 baiser 57.3(n)
    60.54(a)
      42996  NM_143066.3  NP_651323.3 
    worm
    (Caenorhabditis elegans)
    Secernentea F47G9.11 F47G9.1 60.18(n)
    59.46(a)
      179567  NM_073478.3  NP_505879.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ERV25(YML012W)4
    ERV251
    Protein that forms a heterotrimeric complex with Erp1, more4
    ERV251
    48.28(n)1
    43.1(a)1
      13(246116-246751)4
    8549971, 4  NP_013701.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G219001 AT1G21900 48.23(n)
    36.17(a)
      838792  NM_102038.4  NP_173608.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g02101001 Os06g0210100 50.9(n)
    39.25(a)
      4340456  NM_001063647.1  NP_001057112.2 


    ENSEMBL Gene Tree for TMED10 (if available)
    TreeFam Gene Tree for TMED10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TMED10 gene
    2 SIMAP similar genes for TMED10 using alignment to 2 protein entries:     TMEDA_HUMAN (see all proteins):
    TMED9    TMED4

    Find genes that share paralogs with TMED10           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for TMED10
    PGOHUM00000238175 PGOHUM00000249817


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMED10 (see all 926)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1754461,2
    C,F,H--75597732(+) TGAGGG/ATTCAT 1 -- ds500119Minor allele frequency- A:0.01NS EA WA NA CSA 1728
    rs1503891071,2
    --75597754(+) GGGGGA/GTGGGG 1 -- ds50010--------
    rs1873544041,2
    --75597840(+) AAACCA/GCAATT 1 -- ds50010--------
    rs1450980761,2
    --75597855(+) TTGTGC/TGAACC 1 -- ds50010--------
    rs1421309951,2
    --75597856(+) TGTGCA/GAACCT 1 -- ds50010--------
    rs1922595051,2
    --75597864(+) CCTAAC/TAGTAA 1 -- ds50010--------
    rs1848200931,2
    --75598112(+) GAAATA/GTGGAA 1 -- ds50010--------
    rs151561,2
    C--75598259(-) AAAGAG/TGCATA 1 -- ut31 trp33Minor allele frequency- T:0.00MN NA 188
    rs1880881421,2
    --75598492(+) TAATAC/TCAATT 1 -- ut310--------
    rs1459882071,2
    C--75598577(+) TGTCAA/GCTCCT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TMED10 (75598171 - 75643349 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TMED10:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2673828CNV Deletion23128226
    nsv85320CNV Loss16902084
    nsv832833CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605406    OMIM disorders: --


    Find genes that share disorders with TMED10           About GenesLikeMe

    Genetic Association Database (GAD): TMED10
    Human Genome Epidemiology (HuGE) Navigator: TMED10 (2 documents)

    Export disorders for TMED10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMED10 gene, integrated from 10 sources (see all 63):
    (articles sorted by number of sources associating them with TMED10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking. (PubMed id 8663407)1, 2, 3 Blum R.... Schulz I. (J. Biol. Chem. 1996)
    2. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. (PubMed id 7596406)1, 2, 3 Sherrington R....St George-Hyslop P.H. (Nature 1995)
    3. Proteinase-activated receptors, nucleotide P2Y receptors, and mu- opioid receptor-1B are under the control of the type I transmembrane proteins p23 and p24A in post-Golgi trafficking. (PubMed id 21219331)1, 2 Luo W.... Reiser G. (J. Neurochem. 2011)
    4. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PubMed id 20546612)1, 4 Zhao J....Grant S.F. (BMC Med. Genet. 2010)
    5. Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size. (PubMed id 19343178)1, 4 Soranzo N....Deloukas P. (PLoS Genet. 2009)
    6. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (J. Proteome Res. 2006)
    7. TMP21 is a presenilin complex component that modulates gamma- secretase but not epsilon-secretase activity. (PubMed id 16641999)1, 2 Chen F.... Fraser P. (Nature 2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (Nature 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10972 HGNC: 16998 AceView: TMP21 Ensembl:ENSG00000170348 euGenes: HUgn10972
    ECgene: TMED10 H-InvDB: TMED10

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TMED10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMED10 gene:
    Search GeneIP for patents involving TMED10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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