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Aliases for TMED1 Gene

Aliases for TMED1 Gene

  • Transmembrane Emp24 Protein Transport Domain Containing 1 2 3
  • IL1RL1LG 3 4 6
  • Putative T1/ST2 Receptor-Binding Protein 3 4
  • P24 Family Protein Gamma-1 3 4
  • Il1rl1l 3 4
  • Tp24 3 4
  • Transmembrane Emp24 Domain-Containing Protein 1 3
  • Transmembrane Emp24 Domain Containing 1 2
  • Interleukin 1 Receptor-Like 1 Ligand 3
  • Interleukin-1 Receptor-Like 1 Ligand 4
  • IL1RL1-Binding Protein 3
  • P24gamma1 4

External Ids for TMED1 Gene

Summaries for TMED1 Gene

Entrez Gene Summary for TMED1 Gene

  • This gene belongs to the TMED (transmembrane emp24 domain-containing) protein family, which is involved in the vesicular trafficking of proteins. The protein encoded by this gene was identified by its interaction with interleukin 1 receptor-like 1 (IL1RL1) and may play a role in innate immunity. This protein lacks any similarity to other interleukin 1 ligands. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

GeneCards Summary for TMED1 Gene

TMED1 (Transmembrane Emp24 Protein Transport Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include receptor binding. An important paralog of this gene is TMED3.

UniProtKB/Swiss-Prot for TMED1 Gene

  • Potential role in vesicular protein trafficking, mainly in the early secretory pathway. May act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side

Gene Wiki entry for TMED1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMED1 Gene

Genomics for TMED1 Gene

Genomic Location for TMED1 Gene

Start:
10,832,067 bp from pter
End:
10,836,318 bp from pter
Size:
4,252 bases
Orientation:
Minus strand

Genomic View for TMED1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMED1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMED1 Gene

Regulatory Elements for TMED1 Gene

Proteins for TMED1 Gene

  • Protein details for TMED1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13445-TMED1_HUMAN
    Recommended name:
    Transmembrane emp24 domain-containing protein 1
    Protein Accession:
    Q13445
    Secondary Accessions:

    Protein attributes for TMED1 Gene

    Size:
    227 amino acids
    Molecular mass:
    25206 Da
    Quaternary structure:
    • Homodimer in endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment and cis-Golgi network. May interact with IL1RL1.
    Miscellaneous:
    • Found only in very low concentrations in the endoplasmic reticulum, Golgi apparatus and endoplasmic reticulum-Golgi intermediate compartment compared to other members of the EMP24/GP25L family

neXtProt entry for TMED1 Gene

Proteomics data for TMED1 Gene at MOPED

Post-translational modifications for TMED1 Gene

No Post-translational modifications

Other Protein References for TMED1 Gene

No data available for DME Specific Peptides for TMED1 Gene

Domains for TMED1 Gene

Protein Domains for TMED1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TMED1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13445

UniProtKB/Swiss-Prot:

TMED1_HUMAN
Domain:
  • Contains 1 GOLD domain.:
    • Q13445
Family:
  • Belongs to the EMP24/GP25L family.:
    • Q13445
genes like me logo Genes that share domains with TMED1: view

No data available for Gene Families for TMED1 Gene

Function for TMED1 Gene

Molecular function for TMED1 Gene

UniProtKB/Swiss-Prot Function: Potential role in vesicular protein trafficking, mainly in the early secretory pathway. May act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side

Gene Ontology (GO) - Molecular Function for TMED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 8621446
GO:0005515 protein binding IPI 8621446
genes like me logo Genes that share ontologies with TMED1: view

Phenotypes for TMED1 Gene

genes like me logo Genes that share phenotypes with TMED1: view

miRNA for TMED1 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMED1 Gene

Localization for TMED1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMED1 Gene

Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMED1 Gene COMPARTMENTS Subcellular localization image for TMED1 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
plasma membrane 5
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 12237308
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IDA 12237308
GO:0005794 Golgi apparatus IDA 12237308
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with TMED1: view

Pathways for TMED1 Gene

SuperPathways for TMED1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0007165 signal transduction TAS 8621446
GO:0007267 cell-cell signaling TAS 8621446
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with TMED1: view

No data available for Pathways by source for TMED1 Gene

Transcripts for TMED1 Gene

Unigene Clusters for TMED1 Gene

Transmembrane emp24 protein transport domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMED1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6
SP1: -
SP2:
SP3: -

Relevant External Links for TMED1 Gene

GeneLoc Exon Structure for
TMED1
ECgene alternative splicing isoforms for
TMED1

Expression for TMED1 Gene

mRNA expression in normal human tissues for TMED1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMED1 Gene

SOURCE GeneReport for Unigene cluster for TMED1 Gene Hs.515139

mRNA Expression by UniProt/SwissProt for TMED1 Gene

Q13445-TMED1_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with TMED1: view

No data available for mRNA differential expression in normal tissues for TMED1 Gene

Orthologs for TMED1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TMED1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMED1 35
  • 100 (n)
  • 100 (a)
TMED1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMED1 35
  • 90.56 (n)
  • 95.58 (a)
TMED1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMED1 35
  • 91.79 (n)
  • 97.63 (a)
TMED1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmed1 35
  • 87.81 (n)
  • 95.15 (a)
Tmed1 16
Tmed1 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 63 (a)
OneToMany
-- 36
  • 75 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TMED1 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmed1 35
  • 87.67 (n)
  • 94.71 (a)
lizard
(Anolis carolinensis)
Reptilia TMED1 36
  • 49 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15721 35
tropical clawed frog
(Silurana tropicalis)
Amphibia tmed1 35
  • 71.31 (n)
  • 69.23 (a)
zebrafish
(Danio rerio)
Actinopterygii tmed1a 36
  • 51 (a)
OneToMany
tmed1b 35
  • 66.5 (n)
  • 61.65 (a)
tmed1b 36
  • 57 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG31787 36
  • 28 (a)
ManyToMany
opm 36
  • 35 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea K08E4.6 36
  • 31 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EMP24 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10421 36
  • 46 (a)
OneToMany
Species with no ortholog for TMED1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMED1 Gene

ENSEMBL:
Gene Tree for TMED1 (if available)
TreeFam:
Gene Tree for TMED1 (if available)

Paralogs for TMED1 Gene

Paralogs for TMED1 Gene

Selected SIMAP similar genes for TMED1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with TMED1: view

Variants for TMED1 Gene

Sequence variations from dbSNP and Humsavar for TMED1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1802885 -- 10,832,810(-) TAGAA(A/G)GGACG utr-variant-3-prime, nc-transcript-variant
rs2075168 -- 10,832,662(+) GCCCC(A/G)CACCA utr-variant-3-prime, nc-transcript-variant
rs12611335 -- 10,833,364(+) TCCTC(A/G)CCCTG intron-variant
rs12976203 -- 10,834,618(+) gggat(A/T)acaga intron-variant
rs58782346 -- 10,833,742(+) AACCT(C/T)GTCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMED1 Gene

Variant ID Type Subtype PubMed ID
nsv833746 CNV Loss 17160897
nsv833748 CNV Loss 17160897
nsv911049 CNV Loss 21882294
nsv2416 CNV Insertion 18451855
nsv828436 CNV Gain 20364138

Relevant External Links for TMED1 Gene

HapMap Linkage Disequilibrium report
TMED1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMED1 Gene

Disorders for TMED1 Gene

No disorders were found for TMED1 Gene.

No data available for UniProtKB/Swiss-Prot for TMED1 Gene

Publications for TMED1 Gene

  1. Human IL-18 receptor and ST2L are stable and selective markers for the respective type 1 and type 2 circulating lymphocytes. (PMID: 11466339) Chan W.L. … Al-Ali N.A. (J. Immunol. 2001) 2 3 23
  2. Cloning of a putative ligand for the T1/ST2 receptor. (PMID: 8621446) Gayle M.A. … Sims J.E. (J. Biol. Chem. 1996) 2 3 4
  3. Oligomeric state and stoichiometry of p24 proteins in the early secretory pathway. (PMID: 12237308) Jenne N. … Wieland F.T. (J. Biol. Chem. 2002) 3 4
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for TMED1 Gene

Sources for TMED1 Gene

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