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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMED1 Gene

protein-coding   GIFtS: 53
GCID: GC19M010943

Transmembrane Emp24 Protein Transport Domain Containing...

(Previous name: transmembrane emp24 domain containing 1)
  Search for TMED1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transmembrane Emp24 Protein Transport Domain Containing 11 2     IL1RL1-Binding Protein2
IL1RL1LG2 3 5     Interleukin 1 Receptor-Like 1 Ligand2
Putative T1/ST2 Receptor-Binding Protein2 3     Transmembrane Emp24 Domain-Containing Protein 12
Tp242 3     IL1RL1L3
P24 Family Protein Gamma-12 3     Interleukin-1 Receptor-Like 1 Ligand3
Transmembrane Emp24 Domain Containing 11     p24gamma13
Il1rl1l2     

External Ids:    HGNC: 172911   Entrez Gene: 110182   Ensembl: ENSG000000992037   OMIM: 6053955   UniProtKB: Q134453   

Export aliases for TMED1 gene to outside databases

Previous GC identifers: GC19M010805 GC19M010521


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TMED1 Gene:
This gene belongs to the TMED (transmembrane emp24 domain-containing) protein family, which is involved in the
vesicular trafficking of proteins. The protein encoded by this gene was identified by its interaction with
interleukin 1 receptor-like 1 (IL1RL1) and may play a role in innate immunity. This protein lacks any similarity
to other interleukin 1 ligands. Alternative splicing results in multiple transcript variants of this gene.
(provided by RefSeq, Jul 2013)

GeneCards Summary for TMED1 Gene: 
TMED1 (transmembrane emp24 protein transport domain containing 1) is a protein-coding gene. GO annotations related to this gene include protein binding and receptor binding. An important paralog of this gene is TMED5.

UniProtKB/Swiss-Prot: TMED1_HUMAN, Q13445
Function: Potential role in vesicular protein trafficking, mainly in the early secretory pathway. May act as a
cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may
be involved in vesicle coat formation at the cytoplasmic side

Gene Wiki entry for TMED1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMED1 gene promoter:
         Egr-3   p53   AML1a   MAZR   LCR-F1   RORalpha1   POU2F1   POU2F1a   ZIC2/Zic2   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMED1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMED1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMED1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

TMED1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMED1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M010943:  view genomic region     (about GC identifiers)

Start:
10,943,114 bp from pter      End:
10,946,994 bp from pter
Size:
3,881 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TMED1_HUMAN, Q13445 (See protein sequence)
Recommended Name: Transmembrane emp24 domain-containing protein 1 precursor  
Size: 227 amino acids; 25206 Da
Subunit: Homodimer in endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment and cis-Golgi
network. May interact with IL1RL1
Subcellular location: Cell membrane; Single-pass type I membrane protein (Potential). Endoplasmic reticulum
membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I
membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane
protein
Miscellaneous: Found only in very low concentrations in the endoplasmic reticulum, Golgi apparatus and endoplasmic
reticulum-Golgi intermediate compartment compared to other members of the EMP24/GP25L family

Explore the universe of human proteins at neXtProt for TMED1: NX_Q13445

Explore proteomics data for TMED1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13445

  • TMED1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TMED1 Protein Expression
    REFSEQ proteins: NP_006849.1  
    ENSEMBL proteins: 
     ENSP00000214869   ENSP00000464856   ENSP00000468294   ENSP00000468054   ENSP00000464824  
     ENSP00000468492   ENSP00000467690  

    Human Recombinant Protein Products for TMED1: 
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    Sino Biological Recombinant Protein for TMED1
    Sino Biological Cell Lysate for TMED1 
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    Cloud-Clone Corp. Proteins for TMED1 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA12237308
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005793endoplasmic reticulum-Golgi intermediate compartment IDA12237308
    GO:0005794Golgi apparatus IDA12237308
    GO:0005886plasma membrane IEA--

    TMED1 for ontologies           About GeneDecksing



    TMED1 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR009038 GOLD

    Graphical View of Domain Structure for InterPro Entry Q13445

    ProtoNet protein and cluster: Q13445

    1 Blocks protein domain: IPB000348 emp24/gp25L/p24 family

    UniProtKB/Swiss-Prot: TMED1_HUMAN, Q13445
    Similarity: Belongs to the EMP24/GP25L family
    Similarity: Contains 1 GOLD domain


    TMED1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TMED1_HUMAN, Q13445
    Function: Potential role in vesicular protein trafficking, mainly in the early secretory pathway. May act as a
    cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may
    be involved in vesicle coat formation at the cytoplasmic side

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS8621446
    GO:0005515protein binding IPI8621446
         
    TMED1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TMED1:
     Decreased cilium length after   Increased cell number in G1, s 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TMED1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TMED1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMED1 
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    miRNA
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate TMED1:
    hsa-miR-3910 hsa-miR-124 hsa-miR-591 hsa-miR-506 hsa-miR-32* hsa-miR-3714
    SwitchGear 3'UTR luciferase reporter plasmidTMED1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMED1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMED1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for TMED1 (Q134452, 3 ENSP000002148694) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD3P840222, 3MINT-61728 I2D: score=3 
    IL1RL1Q016383, ENSP000002339544I2D: score=3 STRING: ENSP00000233954
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0007165signal transduction TAS8621446
    GO:0007267cell-cell signaling TAS8621446
    GO:0015031protein transport IEA--

    TMED1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMED1

    Search CenterWatch for drugs/clinical trials and news about TMED1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TMED1 gene: 
    NM_006858.3  

    Unigene Cluster for TMED1:

    Transmembrane emp24 protein transport domain containing 1
    Hs.515139  [show with all ESTs]
    Unigene Representative Sequence: NM_006858
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000214869(uc002mpy.3) ENST00000586835 ENST00000591695 ENST00000588259
    ENST00000588289 ENST00000591157 ENST00000589638
    miRNA
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate TMED1:
    hsa-miR-3910 hsa-miR-124 hsa-miR-591 hsa-miR-506 hsa-miR-32* hsa-miR-3714
    SwitchGear 3'UTR luciferase reporter plasmidTMED1 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMED1
    Sirion Biotech Customized lentivirus for stable overexpression of TMED1 
                         Customized lentivirus expression plasmids for stable overexpression of TMED1 
    Primer
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    OriGene qPCR primer pairs and template standards for TMED1
    OriGene qSTAR qPCR primer pairs in human, mouse for TMED1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMED1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMED1

    Additional mRNA sequence: 

    BC002443.1 BC018831.1 U41804.1 

    6 DOTS entries:

    DT.87011600  DT.313439  DT.40200775  DT.121465669  DT.95170024  DT.91765415 

    24/182 AceView cDNA sequences (see all 182):

    BM700580 CA488533 BC018831 AL547697 BM759419 CA454614 AL547027 BQ679074 
    CR612632 AI824366 BQ677820 BU196905 F36493 BM694456 BE301180 BQ687244 
    CB178620 BE729071 BQ673005 U41804 AI400895 BQ684688 BQ680441 CA489090 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for TMED1    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6
    SP1:                          -                           
    SP2:                                                      
    SP3:                                            -         


    ECgene alternative splicing isoforms for TMED1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMED1 expression in normal human tissues (normalized intensities)      TMED1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGGATGGCC
    TMED1 Expression
    About this image


    TMED1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/20 selected tissues (see all 20) fully expand
     
     Uterus (Reproductive System)    fully expand to see all 4 entries
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             testis ; cells in seminiferus ducts   
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Hepatocytes Liver Lobule
             liver ; bile duct cells   
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             ovary ; follicle cells   
     
     Thyroid (Endocrine System)    fully expand to see all 2 entries
             thyroid gland ; glandular cells   

    See TMED1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMED1

    SOURCE GeneReport for Unigene cluster: Hs.515139

    UniProtKB/Swiss-Prot: TMED1_HUMAN, Q13445
    Tissue specificity: Widely expressed

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TMED1 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmed11 , 5 transmembrane emp24 domain containing 11, 5 87.81(n)1
    95.15(a)1
      9 (7.81 cM)5
    170831  NM_010744.31  NP_034874.21 
     215073805 
    lizard
    (Anolis carolinensis)
    Reptilia TMED16
    Uncharacterized protein
    48(a)
    1 ↔ 1
    2(80791256-80799544)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.157212 Xenopus laevis transcribed sequence with weak similarity more 80.09(n)    CA973084.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tmed1b1 transmembrane emp24 protein transport domain containing more 68.19(n)
    63.96(a)
      791158  NM_001080640.1  NP_001074109.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta opm6
    CG317876
    --
    33(a)
    27(a)
    many ↔ many
    many ↔ many
    X(14959475-14960419)
    2L(18284845-18285684)
    worm
    (Caenorhabditis elegans)
    Secernentea K08E4.66
    Protein K08E4.6
    30(a)
    1 → many
    IV(12077101-12078164)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes EMP246
    Component of the p24 complex; binds to GPI anchor ...
    19(a)
    1 → many
    VII(122694-123305)


    ENSEMBL Gene Tree for TMED1 (if available)
    TreeFam Gene Tree for TMED1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TMED1 gene
    TMED52  TICAM22  TMED7-TICAM22  TMED22  TMED32  TMED72  
    2 SIMAP similar genes for TMED1 using alignment to 7 protein entries:     TMED1_HUMAN (see all proteins):
    TMED5    TMED7

    TMED1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/148 SNPs in TMED1 are shown (see all 148)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0365334
    A breast cancer sample4--see VAR_0365332 D N mis40--------
    rs1113735831,2
    C,F--10943099(+) CCCCAG/ATCAGC 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs20751681,2
    C,H--10943338(+) GCCCCG/ACACCA 1 -- ut31 ese34Minor allele frequency- A:0.33EA NS WA 1846
    rs1418242611,2
    C--10943411(+) AATCCA/GAGGCT 1 -- ut310--------
    rs1438104221,2
    --10943523(+) GAGGAC/TGGAAG 1 -- ut310--------
    rs1481746571,2
    C--10943572(+) CTCCCA/GTTTTG 1 -- ut310--------
    rs2007970401,2
    --10943648(+) TGTCCC/TGTTCT 1 -- ut310--------
    rs2001053461,2
    --10943671(+) AGGGGC/TTACGT 2 * syn10--------
    rs2016764861,2
    --10943674(+) GGCTAC/TGTGGG 2 T syn10--------
    rs2011640971,2
    --10943683(+) GGCACC/TGGGCG 2 P syn10--------

    HapMap Linkage Disequilibrium report for TMED1 (10943114 - 10946994 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TMED1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv2416CNV Insertion18451855
    nsv833746CNV Loss17160897
    nsv911049CNV Loss21882294
    nsv833748CNV Loss17160897
    nsv828436CNV Gain20364138

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TMED1
    DNA2.0 Custom Variant and Variant Library Synthesis for TMED1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TMED1 for disorders           About MalaCards
    OMIM gene information: 605395    OMIM disorders: --


    TMED1 for disorders           About GeneDecksing


    Export disorders for TMED1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMED1 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with TMED1)
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    1. Cloning of a putative ligand for the T1/ST2 receptor. (PubMed id 8621446)1, 2, 3 Gayle M.A.... Sims J.E. (1996)
    2. Human IL-18 receptor and ST2L are stable and selective markers for the respective type 1 and type 2 circulating lymphocytes. (PubMed id 11466339)1, 3, 9 Chan W.L....Al-Ali N.A. (2001)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    5. Oligomeric state and stoichiometry of p24 proteins in the early secretory pathway. (PubMed id 12237308)1, 2 Jenne N.... Wieland F.T. (2002)
    6. The GOLD domain-containing protein TMED1 is involved i n interleukin-33 signaling. (PubMed id 23319592)1 Connolly D.J....McGettrick A.F. (2013)
    7. SGTA recognizes a noncanonical ubiquitin-like domain i n the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degra dation. (PubMed id 23246001)1 Xu Y....Ye Y. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    10. Global profiling of protease cleavage sites by chemos elective labeling of protein N-termini. (PubMed id 19892738)2 Xu G....Jaffrey S.R. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11018 HGNC: 17291 AceView: IL1RL1LG Ensembl:ENSG00000099203 euGenes: HUgn11018
    ECgene: TMED1 H-InvDB: TMED1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMED1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TMED1 gene:
    Search GeneIP for patents involving TMED1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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