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Aliases for TMCO6 Gene

Aliases for TMCO6 Gene

  • Transmembrane And Coiled-Coil Domains 6 2 3
  • Transmembrane And Coiled-Coil Domain-Containing Protein 6 3
  • PRO1580 3

External Ids for TMCO6 Gene

Summaries for TMCO6 Gene

GeneCards Summary for TMCO6 Gene

TMCO6 (Transmembrane And Coiled-Coil Domains 6) is a Protein Coding gene. GO annotations related to this gene include protein transporter activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMCO6 Gene

Genomics for TMCO6 Gene

Genomic Location for TMCO6 Gene

Start:
140,639,427 bp from pter
End:
140,645,408 bp from pter
Size:
5,982 bases
Orientation:
Plus strand

Genomic View for TMCO6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMCO6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMCO6 Gene

Regulatory Elements for TMCO6 Gene

Proteins for TMCO6 Gene

  • Protein details for TMCO6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DC7-TMCO6_HUMAN
    Recommended name:
    Transmembrane and coiled-coil domain-containing protein 6
    Protein Accession:
    Q96DC7
    Secondary Accessions:
    • Q9BUU0
    • Q9P198

    Protein attributes for TMCO6 Gene

    Size:
    493 amino acids
    Molecular mass:
    54442 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF69602.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence={ECO:0000305}; Sequence=AAH01910.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH09618.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAW62034.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for TMCO6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMCO6 Gene

Proteomics data for TMCO6 Gene at MOPED

Post-translational modifications for TMCO6 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TMCO6 Gene

Domains for TMCO6 Gene

Protein Domains for TMCO6 Gene

genes like me logo Genes that share domains with TMCO6: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMCO6 Gene

Function for TMCO6 Gene

Gene Ontology (GO) - Molecular Function for TMCO6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 25416956
GO:0008565 protein transporter activity IEA --
genes like me logo Genes that share ontologies with TMCO6: view

miRNA for TMCO6 Gene

miRTarBase miRNAs that target TMCO6

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMCO6 Gene

Localization for TMCO6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMCO6 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMCO6 Gene COMPARTMENTS Subcellular localization image for TMCO6 gene
Compartment Confidence
nucleus 2
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TMCO6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMCO6: view

Pathways for TMCO6 Gene

SuperPathways for TMCO6 Gene

No Data Available

Interacting Proteins for TMCO6 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000378166%0d%0a9606.ENSP00000365576%0d%0a
Selected Interacting proteins: Q96DC7-TMCO6_HUMAN ENSP00000378166 for TMCO6 Gene via MINT STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for TMCO6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006606 protein import into nucleus IEA --
genes like me logo Genes that share ontologies with TMCO6: view

No data available for Pathways by source for TMCO6 Gene

Transcripts for TMCO6 Gene

Unigene Clusters for TMCO6 Gene

Transmembrane and coiled-coil domains 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMCO6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7
SP1:
SP2:
SP3: - -
SP4:

Relevant External Links for TMCO6 Gene

GeneLoc Exon Structure for
TMCO6
ECgene alternative splicing isoforms for
TMCO6

Expression for TMCO6 Gene

mRNA expression in normal human tissues for TMCO6 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMCO6 Gene

SOURCE GeneReport for Unigene cluster for TMCO6 Gene Hs.534333

genes like me logo Genes that share expressions with TMCO6: view

Orthologs for TMCO6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMCO6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMCO6 36
  • 99.59 (n)
  • 99.19 (a)
TMCO6 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMCO6 36
  • 89.18 (n)
  • 87.02 (a)
TMCO6 37
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMCO6 36
  • 87.53 (n)
  • 87.6 (a)
TMCO6 37
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmco6 36
  • 85.03 (n)
  • 83.67 (a)
Tmco6 16
Tmco6 37
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMCO6 37
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMCO6 37
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmco6 36
  • 85.07 (n)
  • 84.25 (a)
chicken
(Gallus gallus)
Aves TMCO6 36
  • 64.91 (n)
  • 60.99 (a)
TMCO6 37
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMCO6 37
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmco6 36
  • 54.7 (n)
  • 49.17 (a)
zebrafish
(Danio rerio)
Actinopterygii TMCO6 37
  • 44 (a)
OneToOne
zgc:162240 36
  • 54.61 (n)
  • 48.54 (a)
Species with no ortholog for TMCO6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMCO6 Gene

ENSEMBL:
Gene Tree for TMCO6 (if available)
TreeFam:
Gene Tree for TMCO6 (if available)

Paralogs for TMCO6 Gene

No data available for Paralogs for TMCO6 Gene

Variants for TMCO6 Gene

Sequence variations from dbSNP and Humsavar for TMCO6 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs702399 -- 140,644,847(+) CTAAC(C/T)TATAT intron-variant
rs753279 -- 140,644,233(+) GTAGT(C/T)GGATT intron-variant
rs753280 -- 140,644,457(+) ACATG(C/T)ATGTA intron-variant
rs3822356 -- 140,642,851(-) GCAGG(C/T)GGGAG intron-variant
rs4147626 -- 140,644,629(-) GGCCA(C/T)AGCCG synonymous-codon, reference

Relevant External Links for TMCO6 Gene

HapMap Linkage Disequilibrium report
TMCO6

No data available for Structural Variations from Database of Genomic Variants (DGV) for TMCO6 Gene

Disorders for TMCO6 Gene

Relevant External Links for TMCO6

Genetic Association Database (GAD)
TMCO6
Human Genome Epidemiology (HuGE) Navigator
TMCO6
genes like me logo Genes that share disorders with TMCO6: view

No data available for UniProtKB/Swiss-Prot for TMCO6 Gene

Publications for TMCO6 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Candidate gene polymorphisms for ischemic stroke. (PMID: 19729601) Matarin M. … Meschia J.F. (Stroke 2009) 3 49
  4. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P. … Inskip P.D. (Cancer Epidemiol. Biomarkers Prev. 2010) 3 49
  5. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S. … Kang D. (Hum. Immunol. 2010) 3 49

Products for TMCO6 Gene

Sources for TMCO6 Gene

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