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Aliases for TMCO6 Gene

Aliases for TMCO6 Gene

  • Transmembrane And Coiled-Coil Domains 6 2 3 5
  • Transmembrane And Coiled-Coil Domain-Containing Protein 6 3
  • PRO1580 3

External Ids for TMCO6 Gene

Previous GeneCards Identifiers for TMCO6 Gene

  • GC05P140000
  • GC05P140001
  • GC05P140019
  • GC05P135164
  • GC05P141230
  • GC05P141560
  • GC05P141662

Summaries for TMCO6 Gene

GeneCards Summary for TMCO6 Gene

TMCO6 (Transmembrane And Coiled-Coil Domains 6) is a Protein Coding gene. GO annotations related to this gene include binding and protein transporter activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMCO6 Gene

Genomics for TMCO6 Gene

Regulatory Elements for TMCO6 Gene

Enhancers for TMCO6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around TMCO6 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMCO6 Gene

140,596,540 bp from pter
140,647,248 bp from pter
50,709 bases
Plus strand

Genomic View for TMCO6 Gene

Genes around TMCO6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMCO6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMCO6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMCO6 Gene

Proteins for TMCO6 Gene

  • Protein details for TMCO6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane and coiled-coil domain-containing protein 6
    Protein Accession:
    Secondary Accessions:
    • Q9BUU0
    • Q9P198

    Protein attributes for TMCO6 Gene

    493 amino acids
    Molecular mass:
    54442 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF69602.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence={ECO:0000305}; Sequence=AAH01910.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH09618.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAW62034.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for TMCO6 Gene


neXtProt entry for TMCO6 Gene

Post-translational modifications for TMCO6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMCO6 Gene

Domains & Families for TMCO6 Gene

Protein Domains for TMCO6 Gene

Suggested Antigen Peptide Sequences for TMCO6 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMCO6: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMCO6 Gene

Function for TMCO6 Gene

Gene Ontology (GO) - Molecular Function for TMCO6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008565 protein transporter activity IEA --
genes like me logo Genes that share ontologies with TMCO6: view

Phenotypes for TMCO6 Gene

GenomeRNAi human phenotypes for TMCO6:
genes like me logo Genes that share phenotypes with TMCO6: view

Animal Model Products

CRISPR Products

miRNA for TMCO6 Gene

miRTarBase miRNAs that target TMCO6

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMCO6 Gene

Localization for TMCO6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMCO6 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMCO6 Gene COMPARTMENTS Subcellular localization image for TMCO6 gene
Compartment Confidence
nucleus 4
mitochondrion 3
cytosol 1
endoplasmic reticulum 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TMCO6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMCO6: view

Pathways & Interactions for TMCO6 Gene

SuperPathways for TMCO6 Gene

No Data Available

Interacting Proteins for TMCO6 Gene

Gene Ontology (GO) - Biological Process for TMCO6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006606 protein import into nucleus IEA --
genes like me logo Genes that share ontologies with TMCO6: view

No data available for Pathways by source and SIGNOR curated interactions for TMCO6 Gene

Drugs & Compounds for TMCO6 Gene

No Compound Related Data Available

Transcripts for TMCO6 Gene

Unigene Clusters for TMCO6 Gene

Transmembrane and coiled-coil domains 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMCO6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7
SP3: - -

Relevant External Links for TMCO6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMCO6 Gene

mRNA expression in normal human tissues for TMCO6 Gene

Protein differential expression in normal tissues from HIPED for TMCO6 Gene

This gene is overexpressed in Plasma (54.9) and Tlymphocyte (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMCO6 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMCO6 Gene:


SOURCE GeneReport for Unigene cluster for TMCO6 Gene:

genes like me logo Genes that share expression patterns with TMCO6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TMCO6 Gene

Orthologs for TMCO6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMCO6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMCO6 34
  • 89.18 (n)
  • 87.02 (a)
TMCO6 35
  • 87 (a)
(Canis familiaris)
Mammalia TMCO6 34
  • 87.53 (n)
  • 87.6 (a)
TMCO6 35
  • 87 (a)
(Mus musculus)
Mammalia Tmco6 34
  • 85.03 (n)
  • 83.67 (a)
Tmco6 16
Tmco6 35
  • 83 (a)
(Pan troglodytes)
Mammalia TMCO6 34
  • 99.59 (n)
  • 99.19 (a)
TMCO6 35
  • 98 (a)
(Rattus norvegicus)
Mammalia Tmco6 34
  • 85.07 (n)
  • 84.25 (a)
(Monodelphis domestica)
Mammalia TMCO6 35
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia TMCO6 35
  • 65 (a)
(Gallus gallus)
Aves TMCO6 34
  • 64.91 (n)
  • 60.99 (a)
TMCO6 35
  • 55 (a)
(Anolis carolinensis)
Reptilia TMCO6 35
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmco6 34
  • 54.7 (n)
  • 49.17 (a)
(Danio rerio)
Actinopterygii zgc:162240 34
  • 54.61 (n)
  • 48.54 (a)
TMCO6 35
  • 44 (a)
Species where no ortholog for TMCO6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMCO6 Gene

Gene Tree for TMCO6 (if available)
Gene Tree for TMCO6 (if available)

Paralogs for TMCO6 Gene

No data available for Paralogs for TMCO6 Gene

Variants for TMCO6 Gene

Sequence variations from dbSNP and Humsavar for TMCO6 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs17208187 - 140,643,653(+) GAAAA(C/G)CGAGG downstream-variant-500B, reference, missense
rs1583292 -- 140,605,060(-) tacca(A/G)agagg intron-variant
rs4147626 -- 140,644,629(-) GGCCA(C/T)AGCCG intron-variant, reference, synonymous-codon
rs4264986 -- 140,613,681(+) ttcta(A/T)cttca intron-variant
rs1820832 -- 140,605,636(-) acgac(G/T)agatc intron-variant

Variation tolerance for TMCO6 Gene

Residual Variation Intolerance Score: 28.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.23; 76.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMCO6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMCO6 Gene

Disorders for TMCO6 Gene

Relevant External Links for TMCO6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMCO6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMCO6 Gene

Publications for TMCO6 Gene

  1. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P. … Inskip P.D. (Cancer Epidemiol. Biomarkers Prev. 2010) 3 46 65
  2. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S. … Kang D. (Hum. Immunol. 2010) 3 46 65
  3. Candidate gene polymorphisms for ischemic stroke. (PMID: 19729601) Matarin M. … Meschia J.F. (Stroke 2009) 3 46 65
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 65

Products for TMCO6 Gene

Sources for TMCO6 Gene

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