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Aliases for TMCO6 Gene

Aliases for TMCO6 Gene

  • Transmembrane And Coiled-Coil Domains 6 2 3 5
  • Transmembrane And Coiled-Coil Domain-Containing Protein 6 3
  • PRO1580 3

External Ids for TMCO6 Gene

Previous GeneCards Identifiers for TMCO6 Gene

  • GC05P140000
  • GC05P140001
  • GC05P140019
  • GC05P135164
  • GC05P141230
  • GC05P141560
  • GC05P141662
  • GC05P141763
  • GC05P141863
  • GC05P141972

Summaries for TMCO6 Gene

GeneCards Summary for TMCO6 Gene

TMCO6 (Transmembrane And Coiled-Coil Domains 6) is a Protein Coding gene. GO annotations related to this gene include binding and protein transporter activity.

Additional gene information for TMCO6 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMCO6 Gene

Genomics for TMCO6 Gene

Regulatory Elements for TMCO6 Gene

Enhancers for TMCO6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H139633 2.1 FANTOM5 Ensembl ENCODE dbSUPER 13.9 -943.2 -943175 40 MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC MEF2D IK APBB3 ANKHD1 TMCO6 TMEM173 LOC101929719 PSD2 DNAJC18 LOC105379194 CXXC5
GH05H140112 2.1 ENCODE 13.4 -482.6 -482565 3 HDGF ARID4B SIN3A ZNF2 CBX5 ZNF416 ZNF207 SP5 ZHX2 MXD4 HARS2 ANKHD1 WDR55 VTRNA1-1 TMCO6 IK PIR63019 GC05P140117
GH05H140690 1.1 ENCODE 25.5 +95.0 95009 2 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ZNF207 TMCO6 LOC102723915 HDAC3 ANKHD1 SRA1 PCDHA4 IK WDR55 HARS2 LOC101929719
GH05H139683 2 FANTOM5 Ensembl ENCODE dbSUPER 13.9 -903.7 -903681 18 HDGF PKNOX1 FOXA2 ARNT ARID4B DMAP1 ZNF2 YY1 ZNF143 ZNF548 ANKHD1 HARS2 WDR55 CXXC5 TMCO6 IK PURA LOC101929719 MATR3 APBB3
GH05H140717 1.2 ENCODE 22.6 +122.6 122597 2 MLX ZNF416 ZNF143 SP3 PPARGC1A MEF2D GLIS1 RCOR2 NBN KDM1A ANKHD1 HARS2 PURA HDAC3 WDR55 PCDHB18P PCDHB19P TMCO6 PCDHB12 HARS
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMCO6 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMCO6 Gene

Chromosome:
5
Start:
140,596,540 bp from pter
End:
140,647,248 bp from pter
Size:
50,709 bases
Orientation:
Plus strand

Genomic View for TMCO6 Gene

Genes around TMCO6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMCO6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMCO6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMCO6 Gene

Proteins for TMCO6 Gene

  • Protein details for TMCO6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DC7-TMCO6_HUMAN
    Recommended name:
    Transmembrane and coiled-coil domain-containing protein 6
    Protein Accession:
    Q96DC7
    Secondary Accessions:
    • Q9BUU0
    • Q9P198

    Protein attributes for TMCO6 Gene

    Size:
    493 amino acids
    Molecular mass:
    54442 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF69602.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence={ECO:0000305}; Sequence=AAH01910.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH09618.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAW62034.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for TMCO6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMCO6 Gene

Post-translational modifications for TMCO6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMCO6 Gene

Domains & Families for TMCO6 Gene

Gene Families for TMCO6 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for TMCO6 Gene

Suggested Antigen Peptide Sequences for TMCO6 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMCO6: view

No data available for UniProtKB/Swiss-Prot for TMCO6 Gene

Function for TMCO6 Gene

Phenotypes From GWAS Catalog for TMCO6 Gene

Gene Ontology (GO) - Molecular Function for TMCO6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0008565 protein transporter activity IEA --
genes like me logo Genes that share ontologies with TMCO6: view

Phenotypes for TMCO6 Gene

GenomeRNAi human phenotypes for TMCO6:
genes like me logo Genes that share phenotypes with TMCO6: view

Animal Model Products

CRISPR Products

miRNA for TMCO6 Gene

miRTarBase miRNAs that target TMCO6

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMCO6
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMCO6 Gene

Localization for TMCO6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMCO6 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMCO6 gene
Compartment Confidence
nucleus 4
mitochondrion 3
plasma membrane 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMCO6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMCO6: view

Pathways & Interactions for TMCO6 Gene

SuperPathways for TMCO6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMCO6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006606 protein import into nucleus IEA --
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with TMCO6: view

No data available for Pathways by source and SIGNOR curated interactions for TMCO6 Gene

Drugs & Compounds for TMCO6 Gene

No Compound Related Data Available

Transcripts for TMCO6 Gene

Unigene Clusters for TMCO6 Gene

Transmembrane and coiled-coil domains 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMCO6
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TMCO6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7
SP1:
SP2:
SP3: - -
SP4:

Relevant External Links for TMCO6 Gene

GeneLoc Exon Structure for
TMCO6
ECgene alternative splicing isoforms for
TMCO6

Expression for TMCO6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMCO6 Gene

Protein differential expression in normal tissues from HIPED for TMCO6 Gene

This gene is overexpressed in Plasma (54.9) and Tlymphocyte (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMCO6 Gene



NURSA nuclear receptor signaling pathways regulating expression of TMCO6 Gene:

TMCO6

SOURCE GeneReport for Unigene cluster for TMCO6 Gene:

Hs.534333

Evidence on tissue expression from TISSUES for TMCO6 Gene

  • Spleen(4.2)
  • Lung(4.1)
  • Pancreas(4.1)
genes like me logo Genes that share expression patterns with TMCO6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMCO6 Gene

Orthologs for TMCO6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMCO6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMCO6 33 34
  • 99.59 (n)
cow
(Bos Taurus)
Mammalia TMCO6 33 34
  • 89.18 (n)
dog
(Canis familiaris)
Mammalia TMCO6 33 34
  • 87.53 (n)
rat
(Rattus norvegicus)
Mammalia Tmco6 33
  • 85.07 (n)
mouse
(Mus musculus)
Mammalia Tmco6 33 16 34
  • 85.03 (n)
oppossum
(Monodelphis domestica)
Mammalia TMCO6 34
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMCO6 34
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMCO6 33 34
  • 64.91 (n)
lizard
(Anolis carolinensis)
Reptilia TMCO6 34
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmco6 33
  • 54.7 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:162240 33
  • 54.61 (n)
TMCO6 34
  • 44 (a)
OneToOne
Species where no ortholog for TMCO6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMCO6 Gene

ENSEMBL:
Gene Tree for TMCO6 (if available)
TreeFam:
Gene Tree for TMCO6 (if available)

Paralogs for TMCO6 Gene

No data available for Paralogs for TMCO6 Gene

Variants for TMCO6 Gene

Sequence variations from dbSNP and Humsavar for TMCO6 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs757982865 Pathogenic 140,647,330(+) CCTTC(G/T)TCAGC nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-3-prime
rs863224084 Pathogenic 140,645,662(-) GAGAC(-/G)AATGT intron-variant, nc-transcript-variant, downstream-variant-500B, reference, utr-variant-3-prime, frameshift-variant
rs778593 Likely benign 140,647,631(+) AGTGC(C/T)CCGGT nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-5-prime
rs778594 Likely benign 140,647,719(+) AAAAG(C/T)ATTGT nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-5-prime
rs1057518631 Uncertain significance 140,647,265(-) TCTGG(-/G)CCCGC nc-transcript-variant, upstream-variant-2KB, reference, utr-variant-3-prime, frameshift-variant

Variation tolerance for TMCO6 Gene

Residual Variation Intolerance Score: 28.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.23; 76.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMCO6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMCO6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMCO6 Gene

Disorders for TMCO6 Gene

Relevant External Links for TMCO6

Genetic Association Database (GAD)
TMCO6
Human Genome Epidemiology (HuGE) Navigator
TMCO6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMCO6

No disorders were found for TMCO6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMCO6 Gene

Publications for TMCO6 Gene

  1. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P … Inskip PD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 45 60
  2. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S … Kang D (Human immunology 2010) 3 45 60
  3. Candidate gene polymorphisms for ischemic stroke. (PMID: 19729601) Matarin M … Meschia JF (Stroke 2009) 3 45 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60

Products for TMCO6 Gene

Sources for TMCO6 Gene

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