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Aliases for TMCO6 Gene

Aliases for TMCO6 Gene

  • Transmembrane And Coiled-Coil Domains 6 2 3 5
  • PRO1580 3

External Ids for TMCO6 Gene

Previous GeneCards Identifiers for TMCO6 Gene

  • GC05P140000
  • GC05P140001
  • GC05P140019
  • GC05P135164
  • GC05P141230
  • GC05P141560

Summaries for TMCO6 Gene

GeneCards Summary for TMCO6 Gene

TMCO6 (Transmembrane And Coiled-Coil Domains 6) is a Protein Coding gene. GO annotations related to this gene include binding and protein transporter activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMCO6 Gene

Genomics for TMCO6 Gene

Regulatory Elements for TMCO6 Gene

Promoters for TMCO6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMCO6 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMCO6 Gene

Chromosome:
5
Start:
140,596,540 bp from pter
End:
140,647,248 bp from pter
Size:
50,709 bases
Orientation:
Plus strand

Genomic View for TMCO6 Gene

Genes around TMCO6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMCO6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMCO6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMCO6 Gene

Proteins for TMCO6 Gene

  • Protein details for TMCO6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DC7-TMCO6_HUMAN
    Recommended name:
    Transmembrane and coiled-coil domain-containing protein 6
    Protein Accession:
    Q96DC7
    Secondary Accessions:
    • Q9BUU0
    • Q9P198

    Protein attributes for TMCO6 Gene

    Size:
    493 amino acids
    Molecular mass:
    54442 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF69602.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence={ECO:0000305}; Sequence=AAH01910.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH09618.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAW62034.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for TMCO6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMCO6 Gene

Proteomics data for TMCO6 Gene at MOPED

Post-translational modifications for TMCO6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMCO6 Gene

Domains & Families for TMCO6 Gene

Protein Domains for TMCO6 Gene

Suggested Antigen Peptide Sequences for TMCO6 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMCO6: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMCO6 Gene

Function for TMCO6 Gene

Phenotypes for TMCO6 Gene

GenomeRNAi human phenotypes for TMCO6:
genes like me logo Genes that share phenotypes with TMCO6: view

Animal Model Products

miRNA for TMCO6 Gene

miRTarBase miRNAs that target TMCO6

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMCO6 Gene

Localization for TMCO6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMCO6 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMCO6 Gene COMPARTMENTS Subcellular localization image for TMCO6 gene
Compartment Confidence
nucleus 4
mitochondrion 3
cytosol 1
endoplasmic reticulum 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for TMCO6 Gene

Pathways & Interactions for TMCO6 Gene

SuperPathways for TMCO6 Gene

No Data Available

Interacting Proteins for TMCO6 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000378166%0d%0a9606.ENSP00000365576%0d%0a
Selected Interacting proteins: Q96DC7-TMCO6_HUMAN ENSP00000378166 for TMCO6 Gene via I2D MINT UniProtKB STRING

Gene Ontology (GO) - Biological Process for TMCO6 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMCO6 Gene

Drugs & Compounds for TMCO6 Gene

No Compound Related Data Available

Transcripts for TMCO6 Gene

Unigene Clusters for TMCO6 Gene

Transmembrane and coiled-coil domains 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMCO6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7
SP1:
SP2:
SP3: - -
SP4:

Relevant External Links for TMCO6 Gene

GeneLoc Exon Structure for
TMCO6
ECgene alternative splicing isoforms for
TMCO6

Expression for TMCO6 Gene

mRNA expression in normal human tissues for TMCO6 Gene

Protein differential expression in normal tissues from HIPED for TMCO6 Gene

This gene is overexpressed in Plasma (54.9) and Tlymphocyte (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for TMCO6 Gene



SOURCE GeneReport for Unigene cluster for TMCO6 Gene Hs.534333

genes like me logo Genes that share expression patterns with TMCO6: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TMCO6 Gene

Orthologs for TMCO6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMCO6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMCO6 35
  • 99.59 (n)
  • 99.19 (a)
TMCO6 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMCO6 36
  • 87 (a)
OneToOne
TMCO6 35
  • 89.18 (n)
  • 87.02 (a)
dog
(Canis familiaris)
Mammalia TMCO6 35
  • 87.53 (n)
  • 87.6 (a)
TMCO6 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmco6 16
Tmco6 36
  • 83 (a)
OneToOne
Tmco6 35
  • 85.03 (n)
  • 83.67 (a)
oppossum
(Monodelphis domestica)
Mammalia TMCO6 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMCO6 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmco6 35
  • 85.07 (n)
  • 84.25 (a)
chicken
(Gallus gallus)
Aves TMCO6 35
  • 64.91 (n)
  • 60.99 (a)
TMCO6 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMCO6 36
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmco6 35
  • 54.7 (n)
  • 49.17 (a)
zebrafish
(Danio rerio)
Actinopterygii TMCO6 36
  • 44 (a)
OneToOne
zgc:162240 35
  • 54.61 (n)
  • 48.54 (a)
Species with no ortholog for TMCO6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMCO6 Gene

ENSEMBL:
Gene Tree for TMCO6 (if available)
TreeFam:
Gene Tree for TMCO6 (if available)

Paralogs for TMCO6 Gene

No data available for Paralogs for TMCO6 Gene

Variants for TMCO6 Gene

Sequence variations from dbSNP and Humsavar for TMCO6 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs17208187 - 140,643,653(+) GAAAA(C/G)CGAGG downstream-variant-500B, reference, missense
rs778582 -- 140,625,231(+) caaca(C/T)agcag intron-variant
rs778583 -- 140,625,525(+) ctatt(C/T)taaca intron-variant
rs778587 -- 140,626,845(+) aagtg(C/T)ccagc intron-variant
rs778588 -- 140,627,426(+) gtagt(C/T)tagta intron-variant

Variation tolerance for TMCO6 Gene

Residual Variation Intolerance Score: 28.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.23; 76.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMCO6 Gene

HapMap Linkage Disequilibrium report
TMCO6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMCO6 Gene

Disorders for TMCO6 Gene

Relevant External Links for TMCO6

Genetic Association Database (GAD)
TMCO6
Human Genome Epidemiology (HuGE) Navigator
TMCO6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMCO6

No disorders were found for TMCO6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMCO6 Gene

Publications for TMCO6 Gene

  1. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S. … Kang D. (Hum. Immunol. 2010) 3 48 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P. … Inskip P.D. (Cancer Epidemiol. Biomarkers Prev. 2010) 3

Products for TMCO6 Gene

Sources for TMCO6 Gene

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