TMCO6 Gene
protein-coding GIFtS: 44
GCID: GC05P140019
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|
transmembrane and coiled-coil domains 6
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Aliases
for TMCO6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane And Coiled-Coil Domains 61 2 | | FLJ397691 | | PRO15801 | | Transmembrane And Coiled-Coil Domain-Containing Protein 62 |
Export aliases for TMCO6 gene to outside databasesPrevious GC identifers: GC05P140000 GC05P140001 GC05P135164 |
Summaries
for TMCO6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TMCO6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_029289.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMCO6 gene promoter:
CREB AP-1 ATF-2 deltaCREB c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMCO6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMCO6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q31.3 Ensembl cytogenetic band: 5q31.3 HGNC cytogenetic band: 5q31.3TMCO6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P140019: view genomic region
(about GC identifiers)
Start:
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140,019,012 bp from pter |
End:
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140,024,993 bp from pter |
Size:
|
5,982 bases |
Orientation:
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plus strand |
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Proteins
for TMCO6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TMCO6_HUMAN, Q96DC7 (See
protein sequence)Recommended Name: Transmembrane and coiled-coil domain-containing protein 6 Size: 493 amino acids; 54442 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=AAF69602.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA; Sequence=AAH01910.1;Type=Erroneous initiation; Sequence=AAH09618.1; Type=Erroneous initiation; Sequence=EAW62034.1; Type=Erroneous genemodel prediction;
Secondary accessions: Q9BUU0 Q9P198Alternative splicing: 2 isoforms: Q96DC7-1 Q96DC7-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TMCO6: NX_Q96DC7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96DC7
TMCO6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060972.3
ENSEMBL proteins: ENSP00000378166 ENSP00000421613 ENSP00000424937 ENSP00000422154 ENSP00000445469 ENSP00000443223 ENSP00000423297 ENSP00000426221 ENSP00000252100 ENSP00000444474
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
TMCO6 for ontologies About GeneDecksing
TMCO6 Antibody Products:
Assay Products for TMCO6: |
Protein
Domains /
Families
for TMCO6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMCO6 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96DC7ProtoNet protein and cluster: Q96DC7 |
Function
for TMCO6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMCO6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMCO6 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TMCO6 (NM_018502) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMCO6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMCO6 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMCO6 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008565 | protein transporter activity |
IEA | -- |
TMCO6 for ontologies About GeneDecksing
|
Pathways & Interactions
for TMCO6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMCO6
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
3 Interacting proteins for TMCO6 (Q96DC72, 3 ENSP000003781664) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006606 | protein import into nucleus |
IEA | -- |
TMCO6 for ontologies About GeneDecksing
|
Drugs & Compounds
for TMCO6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMCO6
Search CenterWatch for drugs/clinical trials and news about TMCO6
|
Transcripts
for TMCO6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMCO6 gene: NM_018502.3 Unigene Cluster for TMCO6: Transmembrane and coiled-coil domains 6 Hs.534333 [show with all ESTs]Unigene Representative Sequence: BC06582815 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000394671(uc003lgl.3 uc003lgm.3 uc010jft.3) ENST00000513002
ENST00000509217 ENST00000511410(uc011czj.1) ENST00000394669 ENST00000504069
ENST00000515653 ENST00000514449 ENST00000505086 ENST00000252100(uc003lgo.3)
ENST00000510336(uc003lgn.3) ENST00000509605 ENST00000515265 ENST00000509269
ENST00000537378
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMCO6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMCO6 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TMCO6 (NM_018502) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMCO6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMCO6 |
Additional cDNA sequence: AK097088.1 AK289495.1 AK301502.1 AK308722.1 BC001910.1 BC009618.1 BC065828.1 18 DOTS entries: DT.92459893 DT.100839141 DT.100839136 DT.120833486 DT.95375434 DT.454420 DT.112834 DT.101980046 DT.100839131 DT.120833464 DT.100024343 DT.100839133 DT.102825302 DT.95170442 DT.95375431 DT.97843997 DT.120833481 DT.95170437 24/533 AceView cDNA sequences (see all 533): BE796974 AW304726 BM450688 BU151163 BQ068524 CB850945 BQ927039 BM810259 BQ957407 BE543042 BC009618 BU682333 BQ428165 BQ774631 BM835072 BU731793 AI971867 BP343329 BE900639 BQ065186 CD513649 BQ918790 BQ935640 BQ267894
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for TMCO6 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 |
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| SP1: | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TMCO6
|
Expression
for TMCO6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMCO6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See TMCO6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMCO6
SOURCE GeneReport for Unigene cluster: Hs.534333
SABiosciences Custom PCR Arrays for TMCO6
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMCO6
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMCO6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMCO6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMCO6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMCO6 |
Orthologs
for TMCO6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TMCO6 gene from 4/10 species (see all 10) About this table
ENSEMBL Gene Tree for TMCO6 (if available)
TreeFam Gene Tree for TMCO6 (if available) |
Paralogs
for TMCO6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TMCO6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMCO6 (140019012 - 140024993 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TMCO6: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMCO6 |
|
Disorders
/ Diseases
for TMCO6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TMCO6 for disorders About GeneDecksing
2  diseases for TMCO6: About MalaCardsmeningioma leukemia
Human Genome Epidemiology (HuGE) Navigator: TMCO6 (5 documents)
Export disorders for TMCO6 gene to outside databases
|
Publications
for TMCO6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMCO6 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMCO6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1 Han S....Kang D. (2010)
- Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1 Rajaraman P....Inskip P.D. (2010)
- Candidate gene polymorphisms for ischemic stroke. (PubMed id 19729601)1 Matarin M....Meschia J.F. (2009)
- Common variation in genes related to innate immunity and risk of adult glioma. (PubMed id 19423540)1 Rajaraman P....Chanock S.J. (2009)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
|
External Searches for TMCO6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMCO6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMCO6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMCO6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMCO6 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMCO6 gene:
Search GeneIP for patents involving TMCO6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMCO6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TMCO6 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMCO6 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMCO6 | | | OriGene Protein Over-expression Lysate for TMCO6 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMCO6 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMCO6 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMCO6 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TMCO6 | | OriGene Custom Protein Services for TMCO6 | | | OriGene Custom Immunoassay Development | | |
| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMCO6 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMCO6 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMCO6 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMCO6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMCO6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMCO6 |
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 |  |  |  | |
| | | | Search Tocris compounds for TMCO6 |
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 | | | TMCO6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMCO6 |
|  |  |  | | | | ThermoFisher Antibodies for TMCO6 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMCO6 |
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