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Aliases for TMCO5A Gene

Aliases for TMCO5A Gene

  • Transmembrane And Coiled-Coil Domains 5A 2 3
  • Transmembrane And Coiled-Coil Domains 5 2 3
  • TMCO5 3 4
  • Transmembrane And Coiled-Coil Domain-Containing Protein 5A 3

External Ids for TMCO5A Gene

Previous HGNC Symbols for TMCO5A Gene

  • TMCO5

Previous GeneCards Identifiers for TMCO5A Gene

  • GC15P036016
  • GC15P038227
  • GC15P015072

Summaries for TMCO5A Gene

GeneCards Summary for TMCO5A Gene

TMCO5A (Transmembrane And Coiled-Coil Domains 5A) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMCO5A Gene

Genomics for TMCO5A Gene

Regulatory Elements for TMCO5A Gene

Genomic Location for TMCO5A Gene

37,921,939 bp from pter
37,967,724 bp from pter
45,786 bases
Plus strand

Genomic View for TMCO5A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMCO5A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMCO5A Gene

Proteins for TMCO5A Gene

  • Protein details for TMCO5A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane and coiled-coil domain-containing protein 5A
    Protein Accession:
    Secondary Accessions:
    • Q8NA63

    Protein attributes for TMCO5A Gene

    288 amino acids
    Molecular mass:
    34174 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMCO5A Gene


neXtProt entry for TMCO5A Gene

Proteomics data for TMCO5A Gene at MOPED

Post-translational modifications for TMCO5A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMCO5A Gene

No data available for DME Specific Peptides for TMCO5A Gene

Domains for TMCO5A Gene

Protein Domains for TMCO5A Gene


Suggested Antigen Peptide Sequences for TMCO5A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMCO5 family.
  • Belongs to the TMCO5 family.
genes like me logo Genes that share domains with TMCO5A: view

No data available for Gene Families for TMCO5A Gene

Function for TMCO5A Gene

Phenotypes for TMCO5A Gene

genes like me logo Genes that share phenotypes with TMCO5A: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMCO5A

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMCO5A Gene

Localization for TMCO5A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMCO5A Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMCO5A Gene COMPARTMENTS Subcellular localization image for TMCO5A gene
Compartment Confidence
cytosol 2
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMCO5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMCO5A: view

Pathways for TMCO5A Gene

SuperPathways for TMCO5A Gene

No Data Available

Interacting Proteins for TMCO5A Gene

Gene Ontology (GO) - Biological Process for TMCO5A Gene


No data available for Pathways by source for TMCO5A Gene

Transcripts for TMCO5A Gene

Unigene Clusters for TMCO5A Gene

Transmembrane and coiled-coil domains 5A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMCO5A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMCO5A Gene

No ASD Table

Relevant External Links for TMCO5A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMCO5A Gene

mRNA expression in normal human tissues for TMCO5A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMCO5A Gene

This gene is overexpressed in Testis (52.4).

Protein differential expression in normal tissues for TMCO5A Gene

This gene is overexpressed in Testis (41.3), Platelet (14.1), and Heart (13.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TMCO5A Gene

SOURCE GeneReport for Unigene cluster for TMCO5A Gene Hs.179646

genes like me logo Genes that share expressions with TMCO5A: view

Expression partners for TMCO5A Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TMCO5A Gene

Orthologs for TMCO5A Gene

This gene was present in the common ancestor of mammals.

Orthologs for TMCO5A Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia TMCO5A 35
  • 84.49 (n)
  • 73.96 (a)
  • 75 (a)
(Mus musculus)
Mammalia Tmco5 35
  • 77.66 (n)
  • 71.18 (a)
Tmco5 16
Tmco5 36
  • 68 (a)
(Pan troglodytes)
Mammalia TMCO5A 35
  • 97.76 (n)
  • 95.07 (a)
  • 95 (a)
(Rattus norvegicus)
Mammalia Tmco5a 35
  • 78.47 (n)
  • 70.83 (a)
(Bos Taurus)
Mammalia TMCO5A 36
  • 71 (a)
(Monodelphis domestica)
Mammalia TMCO5A 36
  • 35 (a)
Species with no ortholog for TMCO5A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMCO5A Gene

Gene Tree for TMCO5A (if available)
Gene Tree for TMCO5A (if available)

Paralogs for TMCO5A Gene

(1) SIMAP similar genes for TMCO5A Gene using alignment to 7 proteins: Pseudogenes for TMCO5A Gene

genes like me logo Genes that share paralogs with TMCO5A: view

No data available for Paralogs for TMCO5A Gene

Variants for TMCO5A Gene

Sequence variations from dbSNP and Humsavar for TMCO5A Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs953451 -- 37,948,263(-) AATAC(C/G)AATTT intron-variant
rs1011273 -- 37,941,100(-) TGTGC(A/G)GGAAT intron-variant
rs1021796 -- 37,941,022(-) CTGAT(A/G)GAGGA intron-variant
rs2202158 -- 37,941,027(-) GTCTC(C/T)TGATA intron-variant
rs2937981 -- 37,934,079(+) ttatt(G/T)tattg upstream-variant-2KB

Relevant External Links for TMCO5A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMCO5A Gene

Disorders for TMCO5A Gene

Relevant External Links for TMCO5A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for TMCO5A Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for TMCO5A Gene

Publications for TMCO5A Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Multi-ethnic genetic association study of carotid intima-media thickness using a targeted cardiovascular SNP microarray. (PMID: 19679847) Lanktree M.B. … Anand S.S. (Stroke 2009) 3 48
  4. Progression-free survival in ovarian cancer is reflected in epigenetic DNA methylation profiles. (PMID: 21577013) Bauerschlag D.O. … Wagner W. (Oncology 2011) 3
  5. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PMID: 17903293) Benjamin E.J. … Vasan R.S. (BMC Med. Genet. 2007) 48

Products for TMCO5A Gene

Sources for TMCO5A Gene

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