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Aliases for TMCO5A Gene

Aliases for TMCO5A Gene

  • Transmembrane And Coiled-Coil Domains 5A 2 3 5
  • Transmembrane And Coiled-Coil Domains 5 2 3
  • TMCO5 3 4
  • Transmembrane And Coiled-Coil Domain-Containing Protein 5A 3
  • Testicular Tissue Protein Li 205 3

External Ids for TMCO5A Gene

Previous HGNC Symbols for TMCO5A Gene

  • TMCO5

Previous GeneCards Identifiers for TMCO5A Gene

  • GC15P036016
  • GC15P038227
  • GC15P015072

Summaries for TMCO5A Gene

GeneCards Summary for TMCO5A Gene

TMCO5A (Transmembrane And Coiled-Coil Domains 5A) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMCO5A Gene

Genomics for TMCO5A Gene

Regulatory Elements for TMCO5A Gene

Enhancers for TMCO5A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F036924 2 VISTA 9.9 -995.8 -995843 2.6 PKNOX1 FEZF1 ZNF2 YY1 KLF7 TSHZ1 ZNF488 TBX21 NFIL3 ATF4 ENSG00000259395 RPS15P8 ENSG00000259639 TMCO5A GC15P036887 MIR8063
GH15F037585 0.6 FANTOM5 3.7 -336.1 -336110 0.1 JUND HLF FOS MAFK TMCO5A GC15P037592 LOC105370772
GH15F037921 0.4 ENCODE 0.8 -0.3 -259 1.0 TAL1 NFE2 TMCO5A GC15P037868
GH15F037933 0.6 ENCODE 0.4 +11.9 11946 1.4 FOSL1 CEBPB FOS KDM1A MAFK TMCO5A LOC101928227
GH15F037899 0.8 Ensembl ENCODE 0.3 -21.1 -21109 1.9 JUND JUN FOS NR2F2 NFE2L2 TMCO5A GC15P037868
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMCO5A on UCSC Golden Path with GeneCards custom track

Genomic Location for TMCO5A Gene

37,921,939 bp from pter
37,995,033 bp from pter
73,095 bases
Plus strand

Genomic View for TMCO5A Gene

Genes around TMCO5A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMCO5A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMCO5A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMCO5A Gene

Proteins for TMCO5A Gene

  • Protein details for TMCO5A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane and coiled-coil domain-containing protein 5A
    Protein Accession:
    Secondary Accessions:
    • Q8NA63

    Protein attributes for TMCO5A Gene

    288 amino acids
    Molecular mass:
    34174 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMCO5A Gene


neXtProt entry for TMCO5A Gene

Post-translational modifications for TMCO5A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMCO5A Gene

Domains & Families for TMCO5A Gene

Protein Domains for TMCO5A Gene


Suggested Antigen Peptide Sequences for TMCO5A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMCO5 family.
  • Belongs to the TMCO5 family.
genes like me logo Genes that share domains with TMCO5A: view

No data available for Gene Families for TMCO5A Gene

Function for TMCO5A Gene

genes like me logo Genes that share phenotypes with TMCO5A: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMCO5A Gene

Localization for TMCO5A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMCO5A Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMCO5A gene
Compartment Confidence
nucleus 2
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMCO5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMCO5A: view

Pathways & Interactions for TMCO5A Gene

SuperPathways for TMCO5A Gene

No Data Available

Interacting Proteins for TMCO5A Gene

Gene Ontology (GO) - Biological Process for TMCO5A Gene


No data available for Pathways by source and SIGNOR curated interactions for TMCO5A Gene

Transcripts for TMCO5A Gene

Unigene Clusters for TMCO5A Gene

Transmembrane and coiled-coil domains 5A:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMCO5A Gene

No ASD Table

Relevant External Links for TMCO5A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMCO5A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMCO5A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMCO5A Gene

This gene is overexpressed in Testis (x52.4).

Protein differential expression in normal tissues from HIPED for TMCO5A Gene

This gene is overexpressed in Testis (41.3), Platelet (14.1), and Heart (13.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMCO5A Gene

Protein tissue co-expression partners for TMCO5A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMCO5A Gene:


SOURCE GeneReport for Unigene cluster for TMCO5A Gene:

genes like me logo Genes that share expression patterns with TMCO5A: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for TMCO5A Gene

Orthologs for TMCO5A Gene

This gene was present in the common ancestor of mammals.

Orthologs for TMCO5A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMCO5A 34 35
  • 97.76 (n)
(Canis familiaris)
Mammalia TMCO5A 34 35
  • 84.49 (n)
(Rattus norvegicus)
Mammalia Tmco5a 34
  • 78.47 (n)
(Mus musculus)
Mammalia Tmco5 34 16 35
  • 77.66 (n)
(Bos Taurus)
Mammalia TMCO5A 35
  • 71 (a)
(Monodelphis domestica)
Mammalia TMCO5A 35
  • 35 (a)
Species where no ortholog for TMCO5A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMCO5A Gene

Gene Tree for TMCO5A (if available)
Gene Tree for TMCO5A (if available)

Paralogs for TMCO5A Gene

(1) SIMAP similar genes for TMCO5A Gene using alignment to 7 proteins: Pseudogenes for TMCO5A Gene

genes like me logo Genes that share paralogs with TMCO5A: view

No data available for Paralogs for TMCO5A Gene

Variants for TMCO5A Gene

Sequence variations from dbSNP and Humsavar for TMCO5A Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs193920912 Uncertain significance 37,947,673(+) CAAAA(A/C/G)ACAGC reference, synonymous-codon, missense
rs1011273 -- 37,941,100(-) TGTGC(A/G)GGAAT intron-variant
rs10152693 -- 37,969,452(+) ACTCT(A/G)AGATA intron-variant
rs10152715 -- 37,969,888(+) atagt(A/G)tatat intron-variant
rs10162793 -- 37,984,033(+) TGAGG(G/T)CATGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMCO5A Gene

Variant ID Type Subtype PubMed ID
esv3892674 CNV gain 25118596

Variation tolerance for TMCO5A Gene

Residual Variation Intolerance Score: 64.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.91; 59.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMCO5A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMCO5A Gene

Disorders for TMCO5A Gene

Relevant External Links for TMCO5A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMCO5A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMCO5A Gene

Publications for TMCO5A Gene

  1. Multi-ethnic genetic association study of carotid intima-media thickness using a targeted cardiovascular SNP microarray. (PMID: 19679847) Lanktree M.B. … Anand S.S. (Stroke 2009) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. Progression-free survival in ovarian cancer is reflected in epigenetic DNA methylation profiles. (PMID: 21577013) Bauerschlag D.O. … Wagner W. (Oncology 2011) 3 64
  5. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. (PMID: 18711365) Ferreira M.A. … Craddock N. (Nat. Genet. 2008) 46 64

Products for TMCO5A Gene

Sources for TMCO5A Gene

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