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Aliases for TMCO4 Gene

Aliases for TMCO4 Gene

  • Transmembrane And Coiled-Coil Domains 4 2 3 5

External Ids for TMCO4 Gene

Previous GeneCards Identifiers for TMCO4 Gene

  • GC01M019881
  • GC01M020009
  • GC01M018254

Summaries for TMCO4 Gene

GeneCards Summary for TMCO4 Gene

TMCO4 (Transmembrane And Coiled-Coil Domains 4) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMCO4 Gene

Genomics for TMCO4 Gene

Regulatory Elements for TMCO4 Gene

Enhancers for TMCO4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMCO4 on UCSC Golden Path with GeneCards custom track

Promoters for TMCO4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMCO4 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMCO4 Gene

19,682,213 bp from pter
19,800,353 bp from pter
118,141 bases
Minus strand

Genomic View for TMCO4 Gene

Genes around TMCO4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMCO4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMCO4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMCO4 Gene

Proteins for TMCO4 Gene

  • Protein details for TMCO4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane and coiled-coil domain-containing protein 4
    Protein Accession:
    Secondary Accessions:
    • Q5TGY2
    • Q6MZN5
    • Q7Z6K6
    • Q9UQP4
    • Q9Y3K1

    Protein attributes for TMCO4 Gene

    634 amino acids
    Molecular mass:
    67910 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAB42850.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB42851.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI19015.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI20091.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for TMCO4 Gene


neXtProt entry for TMCO4 Gene

Proteomics data for TMCO4 Gene at MOPED

Post-translational modifications for TMCO4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMCO4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMCO4 Gene

Domains & Families for TMCO4 Gene

Protein Domains for TMCO4 Gene


Suggested Antigen Peptide Sequences for TMCO4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMCO4 family.
  • Belongs to the TMCO4 family.
genes like me logo Genes that share domains with TMCO4: view

No data available for Gene Families for TMCO4 Gene

Function for TMCO4 Gene

genes like me logo Genes that share phenotypes with TMCO4: view

Animal Model Products

miRNA for TMCO4 Gene

miRTarBase miRNAs that target TMCO4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMCO4 Gene

Localization for TMCO4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMCO4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMCO4 Gene COMPARTMENTS Subcellular localization image for TMCO4 gene
Compartment Confidence
cytoskeleton 1
cytosol 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for TMCO4 Gene

Pathways & Interactions for TMCO4 Gene

SuperPathways for TMCO4 Gene

No Data Available

Interacting Proteins for TMCO4 Gene

Gene Ontology (GO) - Biological Process for TMCO4 Gene


No data available for Pathways by source and SIGNOR curated interactions for TMCO4 Gene

Drugs & Compounds for TMCO4 Gene

No Compound Related Data Available

Transcripts for TMCO4 Gene

Unigene Clusters for TMCO4 Gene

Transmembrane and coiled-coil domains 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMCO4 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^
SP1: - -
SP2: - -
SP3: - - - - - - - -
SP4: - - - - - -
SP5: - - -
SP6: - - - -
SP7: - - -
SP8: - - -
SP9: -
SP10: - -
SP11: - - - - - -

ExUns: 19a · 19b ^ 20a · 20b

Relevant External Links for TMCO4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMCO4 Gene

mRNA expression in normal human tissues for TMCO4 Gene

Protein differential expression in normal tissues from HIPED for TMCO4 Gene

This gene is overexpressed in Blymphocyte (14.6), Placenta (14.4), and CD8 Tcells (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMCO4 Gene

SOURCE GeneReport for Unigene cluster for TMCO4 Gene Hs.656313

genes like me logo Genes that share expression patterns with TMCO4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TMCO4 Gene

Orthologs for TMCO4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TMCO4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMCO4 35
  • 86.52 (n)
  • 87.96 (a)
TMCO4 36
  • 87 (a)
(Canis familiaris)
Mammalia TMCO4 35
  • 88.36 (n)
  • 88.47 (a)
TMCO4 36
  • 88 (a)
(Mus musculus)
Mammalia Tmco4 35
  • 81.75 (n)
  • 82.86 (a)
Tmco4 16
Tmco4 36
  • 82 (a)
(Pan troglodytes)
Mammalia TMCO4 35
  • 99.11 (n)
  • 99.53 (a)
TMCO4 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Tmco4 35
  • 81.9 (n)
  • 83.17 (a)
(Monodelphis domestica)
Mammalia TMCO4 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia TMCO4 36
  • 64 (a)
(Gallus gallus)
Aves TMCO4 35
  • 67.15 (n)
  • 70.57 (a)
TMCO4 36
  • 66 (a)
(Anolis carolinensis)
Reptilia TMCO4 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmco4 35
  • 68.71 (n)
  • 72.94 (a)
(Danio rerio)
Actinopterygii tmco4 35
  • 61.85 (n)
  • 62.74 (a)
tmco4 36
  • 48 (a)
(Caenorhabditis elegans)
Secernentea F35D11.3 35
  • 49.72 (n)
  • 44.65 (a)
F35D11.3 36
  • 35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 14 (a)
MIL1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
Species with no ortholog for TMCO4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMCO4 Gene

Gene Tree for TMCO4 (if available)
Gene Tree for TMCO4 (if available)

Paralogs for TMCO4 Gene

No data available for Paralogs for TMCO4 Gene

Variants for TMCO4 Gene

Sequence variations from dbSNP and Humsavar for TMCO4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10917536 - 19,771,448(-) TGGTG(A/C)AGTGG reference, missense
rs4515815 - 19,694,501(+) CGACA(C/T)GGAGC reference, missense
rs9064 -- 19,682,387(-) GACAC(A/C)ACTAA utr-variant-3-prime
rs960242 -- 19,731,746(-) GACTG(C/T)TTTAA intron-variant
rs960243 -- 19,731,744(-) CTGCT(G/T)TAACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMCO4 Gene

Variant ID Type Subtype PubMed ID
nsv508991 CNV Insertion 20534489
esv2744920 CNV Deletion 23290073
nsv870984 CNV Gain 21882294
esv22015 CNV Loss 19812545

Variation tolerance for TMCO4 Gene

Residual Variation Intolerance Score: 97.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.53; 92.97% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TMCO4 Gene

Disorders for TMCO4 Gene

Relevant External Links for TMCO4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMCO4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMCO4 Gene

Publications for TMCO4 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3

Products for TMCO4 Gene

Sources for TMCO4 Gene