TMCO4 Gene
protein-coding GIFtS: 43
GCID: GC01M020009
|
|
transmembrane and coiled-coil domains 4
| |
Aliases
for TMCO4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane And Coiled-Coil Domains 41 2 | | DKFZp686C232311 | | RP5-1056L3.62 | | Transmembrane And Coiled-Coil Domain-Containing Protein 42 |
Export aliases for TMCO4 gene to outside databasesPrevious GC identifers: GC01M019755 GC01M019881 GC01M018254 |
Summaries
for TMCO4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TMCO4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004610.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMCO4 gene promoter:
USF1 NRSF form 1 NRSF form 2 FOXC1 CBF-A CBF-B USF-1 CP1A NF-Y CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMCO4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMCO4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.13 Ensembl cytogenetic band: 1p36.13 HGNC cytogenetic band: 1p36.13TMCO4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M020009: view genomic region
(about GC identifiers)
Start:
|
20,008,706 bp from pter |
End:
|
20,126,438 bp from pter |
Size:
|
117,733 bases |
Orientation:
|
minus strand |
|
Proteins
for TMCO4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TMCO4_HUMAN, Q5TGY1 (See
protein sequence)Recommended Name: Transmembrane and coiled-coil domain-containing protein 4 Size: 634 amino acids; 67910 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=CAB42850.1; Type=Erroneous initiation; Sequence=CAB42851.1; Type=Erroneous initiation;Sequence=CAI19015.1; Type=Erroneous gene model prediction; Sequence=CAI20091.1; Type=Erroneous gene model prediction;
Secondary accessions: Q5TGY2 Q6MZN5 Q7Z6K6 Q9UQP4 Q9Y3K1Alternative splicing: 2 isoforms: Q5TGY1-1 Q5TGY1-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TMCO4: NX_Q5TGY1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5TGY1
TMCO4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_859070.3
ENSEMBL proteins: ENSP00000294543 ENSP00000364269 ENSP00000364264
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
TMCO4 for ontologies About GeneDecksing
TMCO4 Antibody Products:
Assay Products for TMCO4: |
Protein
Domains /
Families
for TMCO4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMCO4 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q5TGY1ProtoNet protein and cluster: Q5TGY1 UniProtKB/Swiss-Prot: TMCO4_HUMAN, Q5TGY1Similarity: Belongs to the TMCO4 family |
Function
for TMCO4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMCO4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMCO4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TMCO4 (NM_181719) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMCO4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMCO4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMCO4 |
|
Pathways & Interactions
for TMCO4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMCO4
|
Drugs & Compounds
for TMCO4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMCO4
Search CenterWatch for drugs/clinical trials and news about TMCO4
|
Transcripts
for TMCO4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMCO4 gene: NM_181719.4 Unigene Cluster for TMCO4: Transmembrane and coiled-coil domains 4 Hs.656313 [show with all ESTs]Unigene Representative Sequence: NM_18171910 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000294543(uc001bcn.3) ENST00000375127(uc001bco.1 uc001bcp.1 uc009vpn.1 uc001bcq.1)
ENST00000489814 ENST00000494342 ENST00000489135 ENST00000496528 ENST00000462171
ENST00000466661 ENST00000488449 ENST00000375122
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMCO4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMCO4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TMCO4 (NM_181719) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMCO4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMCO4 |
Additional cDNA sequence: AK127543.1 AK309310.1 AK309900.1 AL049846.1 AL049847.1 AL832390.1 BC053600.1 BX640987.1 7 DOTS entries: DT.91725009 DT.101980283 DT.101978489 DT.91725007 DT.100746905 DT.102829491 DT.305237 24/88 AceView cDNA sequences (see all 88): BM796386 BQ073784 CR611925 AW444625 AK127543 BU615798 AL049847 BQ102338 BG574206 AI286312 BQ889336 AW473844 AX775873 AI207250 AL049846 BQ086239 R06078 CB151223 AA357605 BM980086 BE274060 BX343839 BQ772442 C01720
GeneLoc Exon Structure
5/12 Alternative Splicing Database (ASD) splice patterns (SP) for TMCO4 (see all 12) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | |
| SP3: | | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | - | | - | | - | | - | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 19a | · | 19b | ^ | 20a | · | 20b |
|---|
|
| SP1: | | | | | | | | | |
| SP2: | | | | | | | | | |
| SP3: | | | | | | | | | |
| SP4: | | | | | | | | | |
| SP5: | | | | | | | | |
ECgene alternative splicing isoforms for TMCO4
|
Expression
for TMCO4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMCO4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACCACAAAA
About this image
See TMCO4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMCO4
SOURCE GeneReport for Unigene cluster: Hs.656313
SABiosciences Custom PCR Arrays for TMCO4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMCO4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMCO4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMCO4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMCO4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMCO4 |
Orthologs
for TMCO4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TMCO4 gene from 7/23 species (see all 23) About this table
ENSEMBL Gene Tree for TMCO4 (if available)
TreeFam Gene Tree for TMCO4 (if available) |
Paralogs
for TMCO4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TMCO4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMCO4 (20008706 - 20126438 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TMCO4
1 CNV: 68179 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMCO4 |
|
Disorders
/ Diseases
for TMCO4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TMCO4 for disorders About GeneDecksing
1  disease for TMCO4: About MalaCardsmalaria
Human Genome Epidemiology (HuGE) Navigator: TMCO4 (1 document)
Export disorders for TMCO4 gene to outside databases
|
Publications
for TMCO4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMCO4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMCO4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
|
External Searches for TMCO4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMCO4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMCO4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMCO4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMCO4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMCO4 gene:
Search GeneIP for patents involving TMCO4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMCO4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TMCO4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMCO4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMCO4 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMCO4 | | OriGene 3'-UTR Clone for TMCO4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMCO4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMCO4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TMCO4 | | OriGene Custom Protein Services for TMCO4 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMCO4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMCO4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMCO4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMCO4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMCO4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMCO4 |
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 |  |  |  | |
| | | | Search Tocris compounds for TMCO4 |
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 | | | TMCO4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMCO4 |
|  |  |  | | | | Search ThermoFisher Antibodies for TMCO4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMCO4 |
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