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Aliases for TMCO4 Gene

Aliases for TMCO4 Gene

  • Transmembrane And Coiled-Coil Domains 4 2 3 5

External Ids for TMCO4 Gene

Previous GeneCards Identifiers for TMCO4 Gene

  • GC01M019881
  • GC01M020009
  • GC01M018254

Summaries for TMCO4 Gene

GeneCards Summary for TMCO4 Gene

TMCO4 (Transmembrane And Coiled-Coil Domains 4) is a Protein Coding gene.

Additional gene information for TMCO4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMCO4 Gene

Genomics for TMCO4 Gene

Regulatory Elements for TMCO4 Gene

Enhancers for TMCO4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H019764 1.5 FANTOM5 Ensembl ENCODE dbSUPER 20.5 +34.7 34706 2.3 STAT1 JUN FOSL1 JUND ZNF366 STAT3 ID3 KDM1A FOS MAFK TMCO4 AKR7A3 RNF186 ENSG00000235434 PLA2G2A GC01P019759
GH01H019757 1.1 Ensembl ENCODE dbSUPER 18.1 +41.6 41566 2.8 SOX5 SOX13 ZNF623 ZKSCAN1 ZNF121 JUND POLR2A FOS SETDB1 TMCO4 RNF186 ENSG00000235434 GC01P019759 PIR33395
GH01H019715 1.1 Ensembl ENCODE 10.1 +84.7 84652 0.6 TBP RB1 SIN3A FEZF1 ZNF2 RAD21 RFX5 ZNF143 RCOR1 ATF7 HTR6 TMCO4 PIR33395 GC01P019759
GH01H019812 1.4 Ensembl ENCODE dbSUPER 7.9 -14.7 -14708 5.3 ELF3 FOXA2 NFIB ZNF133 ARID4B FEZF1 ZSCAN9 RAD21 RARA YY1 OTUD3 EMC1 TMCO4 ENSG00000235434 RNF186
GH01H019798 1 ENCODE 10.6 +0.6 630 3.3 FOXA2 ZNF2 YY1 GLIS2 ELK1 ZNF207 RUNX3 SP3 KAT8 SMARCA4 TMCO4 AKR7A2 GC01P019759
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMCO4 on UCSC Golden Path with GeneCards custom track

Promoters for TMCO4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000002515 353 1201 FOXA2 ZNF2 GLIS2 ELK1 ZNF207 RUNX3 SP3 KAT8 SMARCA4 ZSCAN16

Genomic Locations for TMCO4 Gene

Genomic Locations for TMCO4 Gene
118,141 bases
Minus strand

Genomic View for TMCO4 Gene

Genes around TMCO4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMCO4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMCO4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMCO4 Gene

Proteins for TMCO4 Gene

  • Protein details for TMCO4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane and coiled-coil domain-containing protein 4
    Protein Accession:
    Secondary Accessions:
    • Q5TGY2
    • Q6MZN5
    • Q7Z6K6
    • Q9UQP4
    • Q9Y3K1

    Protein attributes for TMCO4 Gene

    634 amino acids
    Molecular mass:
    67910 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAB42850.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB42851.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI19015.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI20091.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for TMCO4 Gene


neXtProt entry for TMCO4 Gene

Post-translational modifications for TMCO4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMCO4 Gene

Domains & Families for TMCO4 Gene

Gene Families for TMCO4 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMCO4 Gene


Suggested Antigen Peptide Sequences for TMCO4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMCO4 family.
  • Belongs to the TMCO4 family.
genes like me logo Genes that share domains with TMCO4: view

Function for TMCO4 Gene

Phenotypes From GWAS Catalog for TMCO4 Gene

genes like me logo Genes that share phenotypes with TMCO4: view

miRNA for TMCO4 Gene

miRTarBase miRNAs that target TMCO4

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMCO4 Gene

Localization for TMCO4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMCO4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMCO4 gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMCO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMCO4: view

Pathways & Interactions for TMCO4 Gene

SuperPathways for TMCO4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMCO4 Gene


No data available for Pathways by source and SIGNOR curated interactions for TMCO4 Gene

Drugs & Compounds for TMCO4 Gene

No Compound Related Data Available

Transcripts for TMCO4 Gene

Unigene Clusters for TMCO4 Gene

Transmembrane and coiled-coil domains 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMCO4 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^
SP1: - -
SP2: - -
SP3: - - - - - - - -
SP4: - - - - - -
SP5: - - -
SP6: - - - -
SP7: - - -
SP8: - - -
SP9: -
SP10: - -
SP11: - - - - - -

ExUns: 19a · 19b ^ 20a · 20b

Relevant External Links for TMCO4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMCO4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMCO4 Gene

Protein differential expression in normal tissues from HIPED for TMCO4 Gene

This gene is overexpressed in Blymphocyte (14.6), Placenta (14.4), and CD8 Tcells (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMCO4 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMCO4 Gene:


SOURCE GeneReport for Unigene cluster for TMCO4 Gene:


Evidence on tissue expression from TISSUES for TMCO4 Gene

  • Intestine(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with TMCO4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMCO4 Gene

Orthologs for TMCO4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TMCO4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMCO4 33 34
  • 99.11 (n)
(Canis familiaris)
Mammalia TMCO4 33 34
  • 88.36 (n)
(Bos Taurus)
Mammalia TMCO4 33 34
  • 86.52 (n)
(Rattus norvegicus)
Mammalia Tmco4 33
  • 81.9 (n)
(Mus musculus)
Mammalia Tmco4 33 16 34
  • 81.75 (n)
(Monodelphis domestica)
Mammalia TMCO4 34
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia TMCO4 34
  • 64 (a)
(Gallus gallus)
Aves TMCO4 33 34
  • 67.15 (n)
(Anolis carolinensis)
Reptilia TMCO4 34
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmco4 33
  • 68.71 (n)
(Danio rerio)
Actinopterygii tmco4 33 34
  • 61.85 (n)
(Caenorhabditis elegans)
Secernentea F35D11.3 33 34
  • 49.72 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 34
  • 14 (a)
MIL1 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 53 (a)
Species where no ortholog for TMCO4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMCO4 Gene

Gene Tree for TMCO4 (if available)
Gene Tree for TMCO4 (if available)

Paralogs for TMCO4 Gene

No data available for Paralogs for TMCO4 Gene

Variants for TMCO4 Gene

Sequence variations from dbSNP and Humsavar for TMCO4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000003725 -- 19,681,952(+) TGGCC(C/T)TGCCA downstream-variant-500B
rs1000035066 -- 19,681,984(+) AAAGA(G/T)GAAAG downstream-variant-500B
rs1000045182 -- 19,758,499(+) GCATG(C/G)AGGCT intron-variant
rs1000050094 -- 19,761,295(+) CTCCC(C/T)GAAGC intron-variant
rs1000057358 -- 19,722,229(+) ATCAC(A/T)TGCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMCO4 Gene

Variant ID Type Subtype PubMed ID
nsv508991 CNV insertion 20534489
nsv1003518 CNV loss 25217958
esv3585406 CNV loss 21293372
esv3585405 CNV loss 21293372
esv3577764 CNV loss 25503493
esv3577763 CNV loss 25503493
esv3450715 CNV duplication 20981092
esv22015 CNV loss 19812545

Variation tolerance for TMCO4 Gene

Residual Variation Intolerance Score: 97.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.53; 92.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMCO4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMCO4 Gene

Disorders for TMCO4 Gene

Relevant External Links for TMCO4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMCO4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMCO4 Gene

Publications for TMCO4 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  4. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 60
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 60

Products for TMCO4 Gene

Sources for TMCO4 Gene

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