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Aliases for TMCO3 Gene

Aliases for TMCO3 Gene

  • Transmembrane And Coiled-Coil Domains 3 2 3
  • Putative LAG1-Interacting Protein 3 4
  • C13orf11 3 4
  • Transmembrane And Coiled-Coil Domain-Containing Protein 3 3
  • Chromosome 13 Open Reading Frame 11 2
  • B230339H12Rik 3

External Ids for TMCO3 Gene

Previous HGNC Symbols for TMCO3 Gene

  • C13orf11

Previous GeneCards Identifiers for TMCO3 Gene

  • GC13P113194
  • GC13P114145
  • GC13P094584

Summaries for TMCO3 Gene

GeneCards Summary for TMCO3 Gene

TMCO3 (Transmembrane And Coiled-Coil Domains 3) is a Protein Coding gene. GO annotations related to this gene include solute:proton antiporter activity.

UniProtKB/Swiss-Prot for TMCO3 Gene

  • Probable Na(+)/H(+) antiporter.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMCO3 Gene

Genomics for TMCO3 Gene

Regulatory Elements for TMCO3 Gene

Genomic Location for TMCO3 Gene

Start:
113,490,993 bp from pter
End:
113,554,590 bp from pter
Size:
63,598 bases
Orientation:
Plus strand

Genomic View for TMCO3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMCO3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMCO3 Gene

Proteins for TMCO3 Gene

  • Protein details for TMCO3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWJ1-TMCO3_HUMAN
    Recommended name:
    Transmembrane and coiled-coil domain-containing protein 3
    Protein Accession:
    Q6UWJ1
    Secondary Accessions:
    • Q5JSB1
    • Q6NUN1
    • Q8NG29
    • Q8TCI6
    • Q96EA6
    • Q9NWT2

    Protein attributes for TMCO3 Gene

    Size:
    677 amino acids
    Molecular mass:
    75598 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAM92892.1; Type=Frameshift; Positions=367, 378; Evidence={ECO:0000305}; Sequence=BAB85074.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TMCO3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMCO3 Gene

Proteomics data for TMCO3 Gene at MOPED

Post-translational modifications for TMCO3 Gene

  • Glycosylation at Asn104, Asn206, and Asn230
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMCO3 Gene

Domains for TMCO3 Gene

Protein Domains for TMCO3 Gene

Suggested Antigen Peptide Sequences for TMCO3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UWJ1

UniProtKB/Swiss-Prot:

TMCO3_HUMAN :
  • Q6UWJ1
Family:
  • Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.
genes like me logo Genes that share domains with TMCO3: view

No data available for Gene Families for TMCO3 Gene

Function for TMCO3 Gene

Molecular function for TMCO3 Gene

UniProtKB/Swiss-Prot Function: Probable Na(+)/H(+) antiporter.

Gene Ontology (GO) - Molecular Function for TMCO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015299 solute:proton antiporter activity IEA --
genes like me logo Genes that share ontologies with TMCO3: view

Phenotypes for TMCO3 Gene

genes like me logo Genes that share phenotypes with TMCO3: view

Animal Model Products

CRISPR Products

miRNA for TMCO3 Gene

miRTarBase miRNAs that target TMCO3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMCO3 Gene

Localization for TMCO3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMCO3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMCO3 Gene COMPARTMENTS Subcellular localization image for TMCO3 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TMCO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMCO3: view

Pathways for TMCO3 Gene

SuperPathways for TMCO3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMCO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006812 cation transport --
GO:0055085 transmembrane transport --
GO:1902600 hydrogen ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with TMCO3: view

No data available for Pathways by source for TMCO3 Gene

Transcripts for TMCO3 Gene

Unigene Clusters for TMCO3 Gene

Transmembrane and coiled-coil domains 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMCO3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMCO3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17 ^
SP1: - - - - - - - -
SP2: - - - -
SP3: - - - - - - - - - -
SP4:
SP5: - - - - - - - -
SP6:
SP7: - - - - -
SP8: - -
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

ExUns: 18 ^ 19a · 19b · 19c ^ 20a · 20b · 20c · 20d · 20e ^ 21 ^ 22a · 22b · 22c ^ 23
SP1: -
SP2:
SP3: -
SP4: - - - - -
SP5:
SP6:
SP7: -
SP8: -
SP9: -
SP10: - - -
SP11: -
SP12: - -
SP13:
SP14:
SP15:

Relevant External Links for TMCO3 Gene

GeneLoc Exon Structure for
TMCO3
ECgene alternative splicing isoforms for
TMCO3

Expression for TMCO3 Gene

mRNA expression in normal human tissues for TMCO3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMCO3 Gene

SOURCE GeneReport for Unigene cluster for TMCO3 Gene Hs.317593

genes like me logo Genes that share expressions with TMCO3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMCO3 Gene

Orthologs for TMCO3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TMCO3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMCO3 35
  • 99.21 (n)
  • 99.11 (a)
TMCO3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMCO3 35
  • 77.35 (n)
  • 81.09 (a)
TMCO3 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMCO3 35
  • 83.8 (n)
  • 87.59 (a)
TMCO3 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmco3 35
  • 83.16 (n)
  • 89.51 (a)
Tmco3 16
Tmco3 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMCO3 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMCO3 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmco3 35
  • 82.03 (n)
  • 89.07 (a)
chicken
(Gallus gallus)
Aves TMCO3 35
  • 76.97 (n)
  • 87.72 (a)
TMCO3 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMCO3 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmco3 35
  • 73.1 (n)
  • 82.04 (a)
zebrafish
(Danio rerio)
Actinopterygii tmco3 35
  • 67.3 (n)
  • 70.77 (a)
tmco3 36
  • 67 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons KEA5 35
  • 44.35 (n)
  • 31.75 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToOne
Species with no ortholog for TMCO3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMCO3 Gene

ENSEMBL:
Gene Tree for TMCO3 (if available)
TreeFam:
Gene Tree for TMCO3 (if available)

Paralogs for TMCO3 Gene

No data available for Paralogs for TMCO3 Gene

Variants for TMCO3 Gene

Sequence variations from dbSNP and Humsavar for TMCO3 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs11699 -- 113,549,940(+) CTGTT(A/G)GTCAA utr-variant-3-prime
rs1046518 -- 113,550,054(+) AATAC(A/G)GATGT utr-variant-3-prime
rs1142002 -- 113,526,004(+) tagaa(C/G)aagcc intron-variant
rs1142003 -- 113,526,035(+) cagct(A/C)tgtgc intron-variant
rs1142004 -- 113,526,131(+) ggatg(C/T)ggacg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMCO3 Gene

Variant ID Type Subtype PubMed ID
dgv597e1 CNV Complex 17122850
nsv901074 CNV Loss 21882294
esv2748299 CNV Deletion 23290073
esv2748300 CNV Deletion 23290073
esv2748301 CNV Deletion 23290073
esv2665668 CNV Deletion 23128226
esv2748302 CNV Deletion 23290073
esv2748303 CNV Deletion 23290073
esv2748304 CNV Deletion 23290073
esv2748305 CNV Deletion 23290073
esv2748306 CNV Deletion 23290073
esv2662301 CNV Deletion 23128226
esv2674514 CNV Deletion 23128226
esv2748307 CNV Deletion 23290073
dgv281e201 CNV Deletion 23290073
esv2748309 CNV Deletion 23290073
esv2748310 CNV Deletion 23290073
esv2748311 CNV Deletion 23290073
esv2748312 CNV Deletion 23290073
esv2748313 CNV Deletion 23290073
esv2748314 CNV Deletion 23290073
esv2748315 CNV Deletion 23290073
esv2293160 CNV Deletion 18987734
esv2748316 CNV Deletion 23290073
esv22070 CNV Loss 19812545
dgv282e201 CNV Deletion 23290073
esv2748318 CNV Deletion 23290073
esv2748321 CNV Deletion 23290073
esv2748322 CNV Deletion 23290073
esv2748323 CNV Deletion 23290073
esv2748324 CNV Deletion 23290073

Relevant External Links for TMCO3 Gene

HapMap Linkage Disequilibrium report
TMCO3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMCO3 Gene

Disorders for TMCO3 Gene

No disorders were found for TMCO3 Gene.

No data available for UniProtKB/Swiss-Prot for TMCO3 Gene

Publications for TMCO3 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for TMCO3 Gene

Sources for TMCO3 Gene

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