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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TMCO3 Gene

protein-coding GIFtS: 47
GCID: GC13P114145

transmembrane and coiled-coil domains 3

(Previous name: chromosome 13 open reading frame 11 )
(Previous symbol: C13orf11)

Explore 2 diseases affiliated with
TMCO3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Transmembrane And Coiled-Coil Domains 3¹ ²		Chromosome 13 Open Reading Frame 11¹
C13orf11¹ ² ³		B230339H12Rik²
Putative LAG1-Interacting Protein² ³		Transmembrane And Coiled-Coil Domain-Containing Protein 3²
FLJ20623¹

External Ids:	HGNC: 20329¹	Entrez Gene: 55002²	Ensembl: ENSG00000150403⁷	UniProtKB: Q6UWJ1³

Export aliases for TMCO3 gene to outside databases

Previous GC identifers: GC13P113194 GC13P094584

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TMCO3_HUMAN, Q6UWJ1

Function: Probable Na(+)/H(+) antiporter (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000013.10 NC_018924.1 NT_027140.6

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TMCO3 gene promoter:
GCNF HTF HNF-4alpha2 AP-4 GATA-1 HNF-4alpha1 IRF-7A c-Myb ZID
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TMCO3 promoter sequence

Search SABiosciences Chromatin IP Primers for TMCO3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMCO3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q34 Ensembl cytogenetic band: 13q34 HGNC cytogenetic band: 13q34

TMCO3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMCO3 gene location

GeneLoc information about chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13P114145: view genomic region (about GC identifiers)

Start:	114,145,308 bp from pter	End:	114,204,544 bp from pter
Size:	59,237 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TMCO3_HUMAN, Q6UWJ1 (See protein sequence)

Recommended Name: Transmembrane and coiled-coil domain-containing protein 3 precursor

Size: 677 amino acids; 75598 Da

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Sequence caution: Sequence=AAM92892.1; Type=Frameshift; Positions=367, 378; Sequence=BAB85074.1; Type=Erroneous

initiation;

Secondary accessions: Q5JSB1 Q6NUN1 Q8NG29 Q8TCI6 Q96EA6 Q9NWT2

Alternative splicing: 3 isoforms: Q6UWJ1-1 Q6UWJ1-2 Q6UWJ1-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TMCO3: NX_Q6UWJ1

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6UWJ1

TMCO3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_060375.4

ENSEMBL proteins:

ENSP00000389399 ENSP00000364540

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for TMCO3
	GenScript Custom Purified and Recombinant Proteins Services for TMCO3
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TMCO3

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

TMCO3 for ontologies About GeneDecksing

TMCO3 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	Novus Biologicals TMCO3 Antibodies
	Search for Antibodies for TMCO3 at Abcam
	Uscn Antibodies for TMCO3
	ThermoFisher Antibody for TMCO3

Assay Products for TMCO3:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TMCO3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TMCO3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TMCO3 for domains About GeneDecksing

1 InterPro domain/family:

IPR006153 Cation/H_exchanger

Graphical View of Domain Structure for InterPro Entry Q6UWJ1

ProtoNet protein and cluster: Q6UWJ1

1 Blocks protein family: IPB006153 Sodium/hydrogen exchanger

UniProtKB/Swiss-Prot: TMCO3_HUMAN, Q6UWJ1

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TMCO3_HUMAN, Q6UWJ1

Function: Probable Na(+)/H(+) antiporter (By similarity)

miRNA Products:		OriGene 3'-UTR Clone: TMCO3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMCO3
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate TMCO3:
		hsa-miR-33a* hsa-miR-124 hsa-miR-513a-3p hsa-miR-186 hsa-miR-506
		SwitchGear 3'UTR luciferase reporter plasmid: TMCO3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMCO3 (see all 7) OriGene shRNA RFP: TMCO3 OriGene siRNA: TMCO3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMCO3

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TMCO3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMCO3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMCO3 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TMCO3 (NM_017905)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMCO3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMCO3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TMCO3
		Search LifeMap BioReagents cell lines for TMCO3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMCO3

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0015299	solute:hydrogen antiporter activity	IEA	--

TMCO3 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for TMCO3:

Increased Salmonella enterica

Increased gamma-H2AX phosphory

Animal Models:
Mouse knock-out Tmco3^tm1Lex for TMCO3
1 MGI phenotypic allele

for Tmco3 (no phenotypes)

TMCO3 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TMCO3

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for TMCO3 (Q6UWJ1³ ENSP00000389399⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EGFR	P00533³, ENSP00000275493⁴	I2D: score=2 STRING: ENSP00000275493
UBC	ENSP00000344818⁴	STRING: ENSP00000344818
ELAVL1	ENSP00000385269⁴	STRING: ENSP00000385269

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TMCO3
Search CenterWatch for drugs/clinical trials and news about TMCO3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TMCO3 gene:

NM_017905.4

Unigene Cluster for TMCO3:

Transmembrane and coiled-coil domains 3

Hs.317593 [show with all ESTs]

Unigene Representative Sequence: NM_017905

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000434316(uc001vtu.4) ENST00000375391 ENST00000474393(uc001vtt.4)

ENST00000473287 ENST00000462877 ENST00000465556 ENST00000460039 ENST00000491166

miRNA Products:		OriGene 3'-UTR Clone: TMCO3 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMCO3
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate TMCO3:
		hsa-miR-33a* hsa-miR-124 hsa-miR-513a-3p hsa-miR-186 hsa-miR-506
		SwitchGear 3'UTR luciferase reporter plasmid: TMCO3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMCO3 (see all 7) OriGene shRNA RFP: TMCO3 OriGene siRNA: TMCO3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMCO3

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMCO3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMCO3 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TMCO3 (NM_017905)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMCO3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMCO3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMCO3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TMCO3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMCO3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMCO3

Additional cDNA sequence:

AF209505.1 AK000630.1 AK074415.1 AY358768.1 BC012564.1 BC068515.1

17 DOTS entries:

DT.100786436 DT.95097569 DT.100786438 DT.86849611 DT.120792420 DT.120792423 DT.213962 DT.100786434

DT.95097571 DT.95148673 DT.100762436 DT.100843675 DT.120792430 DT.65285106 DT.91653010 DT.95097564

DT.99953873

24/136 AceView cDNA sequences (see all 136):

BX332198 CA389430 BU621123 BM983620 AI686666 AL553005 CR601002 BM763274

BX361910 AY358768 BU622797 AI701883 BU543645 AI916612 BC068515 AI174442

CB105050 AK074415 CR624956 BI092950 AA137198 CA489567 AL544525 AA322989

GeneLoc Exon Structure

5/15 Alternative Splicing Database (ASD) splice patterns (SP) for TMCO3 (see all 15) About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5a	·	5b	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11	^	12	^	13a	·	13b	·	13c	·	13d	^	14a	·	14b	·	14c	^	15	^	16	^	17	^
SP1:					-																				-		-		-										-		-						-		-
SP2:					-																				-		-		-
SP3:																									-		-		-				-		-		-		-		-						-		-
SP4:
SP5:																							-		-		-		-		-		-						-		-

ExUns:	18	^	19a	·	19b	·	19c	^	20a	·	20b	·	20c	·	20d	·	20e	^	21	^	22a	·	22b	·	22c	^	23
SP1:	-
SP2:
SP3:	-
SP4:													-		-		-				-				-
SP5:

ECgene alternative splicing isoforms for TMCO3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TMCO3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTATAATTAA

About this image

TMCO3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

5 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Spinal Cord

Spinal Ventral Columns

Ventral Spinal Cord Progenitor Cells

Motor Neurons

Brain

Medulla Oblongata

Brain

Neural Tube

Mesencephalic Ventricular Zone

Neural Tube

Metencephalon

Neural Tube

Spinal Cord

Spinal Ventral Columns

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TMCO3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMCO3

SOURCE GeneReport for Unigene cluster: Hs.317593

SABiosciences Custom PCR Arrays for TMCO3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMCO3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TMCO3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMCO3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMCO3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMCO3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for TMCO3 gene from 6/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tmco3^{1 , 5}	transmembrane and coiled-coil domains 3^{1, 5}	83.16(n)¹ 89.51(a)¹		8 (5.73 cM)⁵ 234076¹ NM_172282.2¹ NP_758486.1¹ 13288013⁵
chicken (Gallus gallus)	Aves	TMCO3¹	transmembrane and coiled-coil domains 3	76.97(n) 87.72(a)		395675 NM_204867.2 NP_990198.2
zebrafish (Danio rerio)	Actinopterygii	tmco3¹	transmembrane and coiled-coil domains 3	67.24(n) 70.53(a)		564309 XM_002660320.2 XP_002660366.2
thale cress (Arabidopsis thaliana)	eudicotyledons	KEA5¹	K(+) efflux antiporter 5	44.35(n) 31.53(a)		835245 NM_124550.1 NP_568763.1
rice (Oryza sativa)	Liliopsida	-- -- (see all 22)	ATCHX, putative, expressed (see all 22)	9(a) (see all 22)	possible ortholog possible ortholog (see all 22)	1(42756787-42757563) 5(11334982-11337858)
E. coli (Escherichia coli)	Gamma proteobacteria	ybaL⁶ kefB⁶ (see all 3)	potassium:proton antiporter (see all 3)	16(a) 14(a) (see all 3)	many → 1 many → 1 (see all 3)	Chromosome(500786-502462) Chromosome(3476824-3478629)

ENSEMBL Gene Tree for TMCO3 (if available)
TreeFam Gene Tree for TMCO3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Clinical significance	Chr 13 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs145563224^1,2	--	114143320(+)	`TGAAAC/TACGAC`	2	--	us2k¹ int¹		0	--	--	--	--
rs148864326^1,2	--	114143362(+)	`GTAAAA/GTGGAA`	2	--	us2k¹ int¹		0	--	--	--	--
rs146986297^1,2	--	114143445(+)	`ACTACG/TTAAGT`	2	--	us2k¹ int¹		0	--	--	--	--
rs191602636^1,2	--	114143530(+)	`GGATCC/TCCAAC`	2	--	int¹ us2k¹		0	--	--	--	--
rs182187095^1,2	--	114143656(+)	`ACCTGC/TCCAGG`	2	--	us2k¹ int¹		0	--	--	--	--
rs139107983^1,2	--	114143708(+)	`CGCAGG/TGACCC`	2	--	us2k¹ int¹		0	--	--	--	--
rs188108451^1,2	--	114143767(+)	`CTGCTC/TTTTTG`	2	--	us2k¹ int¹		0	--	--	--	--
rs141670031^1,2	--	114143808(+)	`TAAACG/TCCATC`	2	--	us2k¹ int¹		0	--	--	--	--
rs147031064^1,2	--	114143856(+)	`CTACCA/GGCCCC`	2	--	us2k¹ int¹		0	--	--	--	--
rs192841650^1,2	--	114143861(+)	`AGCCCC/TCTCTC`	2	--	us2k¹ int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TMCO3 (114145308 - 114204544 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for TMCO3
2 CNVs: 71813 3928
1 Indel: 45132

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMCO3

DNA2.0 Custom Variant and Variant Library Synthesis for TMCO3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TMCO3 for disorders About GeneDecksing

2 diseases for TMCO3: About MalaCards

tuberculosis mycobacterium tuberculosis

Export disorders for TMCO3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TMCO3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMCO3)

Utopia: connect your pdf to the dynamic
world of online information

The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)^{1, 2} Dunham A.... Ross M.T. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)¹ Emanuele M.J....Elledge S.J. (2011)
Regulation of epidermal growth factor receptor traffi cking by lysine deacetylase HDAC6. (PubMed id 20029029)¹ Deribe Y.L....Dikic I. (2009)
Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)¹ Abdelmohsen K....Gorospe M. (2009)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 55002	HGNC: 20329	AceView: C13orf11	Ensembl:ENSG00000150403	euGenes: HUgn55002
ECgene: TMCO3	H-InvDB: TMCO3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for TMCO3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TMCO3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TMCO3 gene:
Search GeneIP for patents involving TMCO3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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transmembrane and coiled-coil domains 3

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TMCO3 Gene

transmembrane and coiled-coil domains 3

Aliasesfor TMCO3 gene

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for TMCO3 gene

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for TMCO3 gene

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for TMCO3 gene

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for TMCO3 gene

Transcripts
for TMCO3 gene

Expression
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Orthologs
for TMCO3 gene

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for TMCO3 gene

Genomic Variants
for TMCO3 gene

Disorders / Diseases
for TMCO3 gene

Publications
for TMCO3 gene

Intellectual Property
for TMCO3 gene

Products
for TMCO3 gene