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Aliases for TMCO2 Gene

Aliases for TMCO2 Gene

  • Transmembrane And Coiled-Coil Domains 2 2 3
  • Transmembrane And Coiled-Coil Domain-Containing Protein 2 3
  • DJ39G22.2 (Novel Protein) 3
  • DJ39G22.2 3

External Ids for TMCO2 Gene

Previous GeneCards Identifiers for TMCO2 Gene

  • GC01P040384
  • GC01P040486
  • GC01P040711
  • GC01P038832

Summaries for TMCO2 Gene

GeneCards Summary for TMCO2 Gene

TMCO2 (Transmembrane And Coiled-Coil Domains 2) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMCO2 Gene

Genomics for TMCO2 Gene

Genomic Location for TMCO2 Gene

40,245,947 bp from pter
40,251,693 bp from pter
5,747 bases
Plus strand

Genomic View for TMCO2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMCO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMCO2 Gene

Proteins for TMCO2 Gene

  • Protein details for TMCO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane and coiled-coil domain-containing protein 2
    Protein Accession:
    Secondary Accessions:

    Protein attributes for TMCO2 Gene

    182 amino acids
    Molecular mass:
    20071 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMCO2 Gene

Proteomics data for TMCO2 Gene at MOPED

Post-translational modifications for TMCO2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMCO2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMCO2 Gene

Domains for TMCO2 Gene

Protein Domains for TMCO2 Gene


Suggested Antigen Peptide Sequences for TMCO2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMCO2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMCO2 Gene

Function for TMCO2 Gene

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMCO2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMCO2 Gene

Localization for TMCO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMCO2 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMCO2 Gene COMPARTMENTS Subcellular localization image for TMCO2 gene
Compartment Confidence
cytosol 3
plasma membrane 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMCO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMCO2: view

Pathways for TMCO2 Gene

SuperPathways for TMCO2 Gene

No Data Available

Interacting Proteins for TMCO2 Gene

Gene Ontology (GO) - Biological Process for TMCO2 Gene


No data available for Pathways by source for TMCO2 Gene

Transcripts for TMCO2 Gene

mRNA/cDNA for TMCO2 Gene

(32) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMCO2 Gene

Transmembrane and coiled-coil domains 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMCO2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMCO2 Gene

No ASD Table

Relevant External Links for TMCO2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMCO2 Gene

mRNA expression in normal human tissues for TMCO2 Gene

mRNA differential expression in normal tissues according to GTEx for TMCO2 Gene

This gene is overexpressed in Testis (51.8).

Protein differential expression in normal tissues for TMCO2 Gene

This gene is overexpressed in Testis (67.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TMCO2 Gene

SOURCE GeneReport for Unigene cluster for TMCO2 Gene Hs.406265

genes like me logo Genes that share expressions with TMCO2: view

Expression partners for TMCO2 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TMCO2 Gene

Orthologs for TMCO2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TMCO2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMCO2 35
  • 85.98 (n)
  • 78.05 (a)
TMCO2 36
  • 74 (a)
(Canis familiaris)
Mammalia TMCO2 35
  • 87.72 (n)
  • 76.61 (a)
TMCO2 36
  • 76 (a)
(Mus musculus)
Mammalia Tmco2 35
  • 85.85 (n)
  • 78.49 (a)
Tmco2 16
Tmco2 36
  • 73 (a)
(Pan troglodytes)
Mammalia TMCO2 35
  • 99.63 (n)
  • 98.9 (a)
TMCO2 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Tmco2 35
  • 85.85 (n)
  • 77.33 (a)
(Monodelphis domestica)
Mammalia TMCO2 36
  • 43 (a)
Species with no ortholog for TMCO2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMCO2 Gene

Gene Tree for TMCO2 (if available)
Gene Tree for TMCO2 (if available)

Paralogs for TMCO2 Gene

No data available for Paralogs for TMCO2 Gene

Variants for TMCO2 Gene

Sequence variations from dbSNP and Humsavar for TMCO2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs113128834 -- 40,247,677(+) CCATA(C/T)TGGAC upstream-variant-2KB
rs149539085 -- 40,250,284(+) TGCAG(C/T)GGTCC intron-variant
rs149734874 -- 40,251,416(+) CTTGG(A/G)TCTGC missense, reference
rs150269741 -- 40,251,534(+) CCCTA(C/T)TGCAG reference, synonymous-codon
rs182100355 -- 40,247,585(+) ACAGG(C/T)GTGAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMCO2 Gene

Variant ID Type Subtype PubMed ID
nsv829660 CNV Gain+Loss 17160897

Relevant External Links for TMCO2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMCO2 Gene

Disorders for TMCO2 Gene

No disorders were found for TMCO2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TMCO2 Gene

Publications for TMCO2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  3. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S. … Oliva R. (Proteomics 2011) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TMCO2 Gene

Sources for TMCO2 Gene

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