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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMCO2 Gene

protein-coding   GIFtS: 36
GCID: GC01P040711

Transmembrane And Coiled-Coil Domains 2

  Search for TMCO2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transmembrane And Coiled-Coil Domains 21 2
dJ39G22.22
DJ39G22.2 (Novel Protein)2
Transmembrane And Coiled-Coil Domain-Containing Protein 22

External Ids:    HGNC: 233121   Entrez Gene: 1273912   Ensembl: ENSG000001888007   UniProtKB: Q7Z6W13   

Export aliases for TMCO2 gene to outside databases

Previous GC identifers: GC01P040384 GC01P040486 GC01P038832


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TMCO2 Gene: 
TMCO2 (transmembrane and coiled-coil domains 2) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMCO2 gene promoter:
         Oct-B1   oct-B3   oct-B2   HNF-4alpha2   CUTL1   HNF-4alpha1   PPAR-gamma1   POU2F1   Nkx6-1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMCO2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMCO2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMCO2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.2   Ensembl cytogenetic band:  1p34.2   HGNC cytogenetic band: 1p34.2

TMCO2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMCO2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P040711:  view genomic region     (about GC identifiers)

Start:
40,711,619 bp from pter      End:
40,717,365 bp from pter
Size:
5,747 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TMCO2_HUMAN, Q7Z6W1 (See protein sequence)
Recommended Name: Transmembrane and coiled-coil domain-containing protein 2  
Size: 182 amino acids; 20071 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)

Explore the universe of human proteins at neXtProt for TMCO2: NX_Q7Z6W1

Explore proteomics data for TMCO2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q7Z6W1

  • TMCO2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TMCO2 Protein Expression
    REFSEQ proteins: NP_001008740.1  
    ENSEMBL proteins: 
     ENSP00000361852  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    TMCO2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q7Z6W1


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TMCO2 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMCO2

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for TMCO2 (ENSP000003618524) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DYRK3ENSP000003560764STRING: ENSP00000356076
    LCE2CENSP000003577724STRING: ENSP00000357772
    LCE2DENSP000003577734STRING: ENSP00000357773
    LCE4AENSP000003352234STRING: ENSP00000335223
    --ENSP000003908354STRING: ENSP00000390835
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMCO2

    Search CenterWatch for drugs/clinical trials and news about TMCO2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TMCO2 gene: 
    NM_001008740.3  

    Unigene Cluster for TMCO2:

    Transmembrane and coiled-coil domains 2
    Hs.406265  [show with all ESTs]
    Unigene Representative Sequence: BI829449
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000468258 ENST00000372766(uc001cfe.2)
    miRNA
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMCO2
    Sirion Biotech Customized lentivirus for stable overexpression of TMCO2 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMCO2
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    Additional mRNA sequence: BC108666.1 

    3 DOTS entries:

    DT.409636  DT.100671811  DT.100662257 

    24/32 AceView cDNA sequences (see all 32):

    AA626247 BX113827 AI201263 AA778498 AI187708 CR613757 BX416836 AA442366 
    AA625857 AA437287 BU569625 AI917789 BU567634 AA927799 BI829242 BU569147 
    AI961118 AI203907 AI678062 BM563243 AI337034 AA609166 BI829432 BG215994 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMCO2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGCAGTGG
    TMCO2 Expression
    About this image


    See TMCO2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMCO2

    SOURCE GeneReport for Unigene cluster: Hs.406265
        SABiosciences Custom PCR Arrays for TMCO2
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMCO2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for TMCO2 gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmco21 , 5 transmembrane and coiled-coil domains 21, 5 85.12(n)1
    77.4(a)1
      4 (56.80 cM)5
    694691  NM_001081312.11  NP_001074781.11 
     1211056515 


    ENSEMBL Gene Tree for TMCO2 (if available)
    TreeFam Gene Tree for TMCO2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/150 SNPs in TMCO2 are shown (see all 150)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs94390171,2
    C,F,H--38830510(+) CGCACC/TTGTGA 1 -- us2k111Minor allele frequency- N:0.00NS EA NA WA 986
    rs94390181,2
    C,F,A,H--38830591(+) GCCAAG/AGCTTT 1 -- us2k121Minor allele frequency- A:0.32NS EA NA WA CSA 2343
    rs1382257341,2
    --38830593(+) CAAAGA/CTTTGT 1 -- us2k10--------
    rs1837080711,2
    --40711605(+) ACTACG/TATAGC 1 -- us2k10--------
    rs1436057521,2
    --40711671(+) CCAGGC/TATTTT 1 -- us2k10--------
    rs793899511,2
    C,F--40711754(+) AAAGGC/TGGACT 1 -- us2k11Minor allele frequency- T:0.01NA 120
    rs1505733911,2
    --40711808(+) CAAGGC/TAGGAG 1 -- us2k10--------
    rs726706291,2
    C--40711810(+) AGGTAC/GGAGGA 1 -- us2k10--------
    rs1891560591,2
    --40711872(+) ATTTCC/TACTAA 1 -- us2k10--------
    rs1492725311,2
    --40711898(+) CCAGGC/TGTGGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TMCO2 (40711619 - 40717365 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TMCO2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv829660CNV Gain+Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMCO2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TMCO2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 127391 HGNC: 23312 AceView: LOC127391 Ensembl:ENSG00000188800 euGenes: HUgn127391
    ECgene: TMCO2 H-InvDB: TMCO2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMCO2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TMCO2 gene:
    Search GeneIP for patents involving TMCO2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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     ELISAs for TMCO2
     CLIAs for TMCO2
     Search LifeMap BioReagents cell lines for TMCO2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMCO2
     Browse SwitchGear 3'UTR luciferase reporter plasmids for TMCO2
     SwitchGear Promoter luciferase reporter plasmids for TMCO2
     Search ThermoFisher Antibodies for TMCO2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMCO2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TMCO2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TMCO2
    Customized:
     lentivirus for stable overexpression of TMCO2
     lentivirus expression plasmids for stable overexpression of TMCO2
     adenovirus for overexpression of TMCO2
     Search LSBio for Antibodies for TMCO2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
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