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Aliases for TMCO2 Gene

Aliases for TMCO2 Gene

  • Transmembrane And Coiled-Coil Domains 2 2 3 5
  • Testis Tissue Sperm-Binding Protein Li 35a 3
  • DJ39G22.2 (Novel Protein) 3
  • DJ39G22.2 3

External Ids for TMCO2 Gene

Previous GeneCards Identifiers for TMCO2 Gene

  • GC01P040384
  • GC01P040486
  • GC01P040711
  • GC01P038832

Summaries for TMCO2 Gene

GeneCards Summary for TMCO2 Gene

TMCO2 (Transmembrane And Coiled-Coil Domains 2) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMCO2 Gene

Genomics for TMCO2 Gene

Regulatory Elements for TMCO2 Gene

Enhancers for TMCO2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMCO2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMCO2 Gene

40,245,947 bp from pter
40,251,693 bp from pter
5,747 bases
Plus strand

Genomic View for TMCO2 Gene

Genes around TMCO2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMCO2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMCO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMCO2 Gene

Proteins for TMCO2 Gene

  • Protein details for TMCO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane and coiled-coil domain-containing protein 2
    Protein Accession:

    Protein attributes for TMCO2 Gene

    182 amino acids
    Molecular mass:
    20071 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMCO2 Gene

Proteomics data for TMCO2 Gene at MOPED

Post-translational modifications for TMCO2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMCO2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMCO2 Gene

Domains & Families for TMCO2 Gene

Protein Domains for TMCO2 Gene


Suggested Antigen Peptide Sequences for TMCO2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMCO2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMCO2 Gene

Function for TMCO2 Gene

Phenotypes for TMCO2 Gene

genes like me logo Genes that share phenotypes with TMCO2: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMCO2 Gene

Localization for TMCO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMCO2 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMCO2 Gene COMPARTMENTS Subcellular localization image for TMCO2 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMCO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMCO2: view

Pathways & Interactions for TMCO2 Gene

SuperPathways for TMCO2 Gene

No Data Available

Interacting Proteins for TMCO2 Gene

Gene Ontology (GO) - Biological Process for TMCO2 Gene


No data available for Pathways by source and SIGNOR curated interactions for TMCO2 Gene

Drugs & Compounds for TMCO2 Gene

No Compound Related Data Available

Transcripts for TMCO2 Gene

mRNA/cDNA for TMCO2 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(32) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMCO2 Gene

Transmembrane and coiled-coil domains 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMCO2 Gene

No ASD Table

Relevant External Links for TMCO2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMCO2 Gene

mRNA expression in normal human tissues for TMCO2 Gene

mRNA differential expression in normal tissues according to GTEx for TMCO2 Gene

This gene is overexpressed in Testis (x51.8).

Protein differential expression in normal tissues from HIPED for TMCO2 Gene

This gene is overexpressed in Testis (67.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMCO2 Gene

SOURCE GeneReport for Unigene cluster for TMCO2 Gene Hs.406265

genes like me logo Genes that share expression patterns with TMCO2: view

Protein tissue co-expression partners for TMCO2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TMCO2 Gene

Orthologs for TMCO2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TMCO2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMCO2 35
  • 85.98 (n)
  • 78.05 (a)
TMCO2 36
  • 74 (a)
(Canis familiaris)
Mammalia TMCO2 35
  • 87.72 (n)
  • 76.61 (a)
TMCO2 36
  • 76 (a)
(Mus musculus)
Mammalia Tmco2 35
  • 85.85 (n)
  • 78.49 (a)
Tmco2 16
Tmco2 36
  • 73 (a)
(Pan troglodytes)
Mammalia TMCO2 35
  • 99.63 (n)
  • 98.9 (a)
TMCO2 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Tmco2 35
  • 85.85 (n)
  • 77.33 (a)
(Monodelphis domestica)
Mammalia TMCO2 36
  • 43 (a)
Species with no ortholog for TMCO2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMCO2 Gene

Gene Tree for TMCO2 (if available)
Gene Tree for TMCO2 (if available)

Paralogs for TMCO2 Gene

No data available for Paralogs for TMCO2 Gene

Variants for TMCO2 Gene

Sequence variations from dbSNP and Humsavar for TMCO2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs3075101 -- 40,249,302(+) tgtgt(-/GT)ACGCG intron-variant
rs6675059 -- 40,250,629(+) tataa(C/G)cttgg intron-variant
rs6692520 -- 40,247,098(+) atcgc(A/G)ccact upstream-variant-2KB
rs6688124 -- 40,251,081(+) GTAGT(A/G)AGCTG intron-variant
rs6679730 -- 40,247,307(+) gtggc(C/T)attta upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMCO2 Gene

Variant ID Type Subtype PubMed ID
nsv829660 CNV Gain+Loss 17160897

Variation tolerance for TMCO2 Gene

Residual Variation Intolerance Score: 47.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.19; 24.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMCO2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMCO2 Gene

Disorders for TMCO2 Gene

Relevant External Links for TMCO2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMCO2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMCO2 Gene

Publications for TMCO2 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 67
  2. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S. … Oliva R. (Proteomics 2011) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TMCO2 Gene

Sources for TMCO2 Gene