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TMCO1 Gene

protein-coding   GIFtS: 50
GCID: GC01M165693

Transmembrane And Coiled-Coil Domains 1

(Previous name: transmembrane and coiled-coil domains 4)
(Previous symbol: TMCC4)
  See TMCO1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane And Coiled-Coil Domains 11 2     PNAS-1362
TMCC41 2 3     Putative Membrane Protein2
Transmembrane And Coiled-Coil Domains 41 2     Transmembrane And Coiled-Coil Domain-Containing Protein 12
Xenogeneic Cross-Immune Protein PCIA32 3     Transmembrane And Coiled-Coil Domains Protein 43
HP101222     CFSMR5
PCIA32     

External Ids:    HGNC: 181881   Entrez Gene: 544992   Ensembl: ENSG000001431837   OMIM: 6141235   UniProtKB: Q9UM003   

Export aliases for TMCO1 gene to outside databases

Previous GC identifers: GC01M162429 GC01M163962 GC01M136941


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TMCO1 Gene:
This locus encodes a transmembrane protein. Mutations at this locus have been associated with craniofacial
dysmorphism, skeletal anomalies, and mental retardation. Mutations at this locus have also been associated with
open angle glaucoma blindness. Alternatively spliced transcript variants have been described. (provided by
RefSeq, Jan 2012)

GeneCards Summary for TMCO1 Gene:
TMCO1 (transmembrane and coiled-coil domains 1) is a protein-coding gene. Diseases associated with TMCO1 include craniofacial dysmorphism, skeletal anomalies, and mental retardation syndrome, and open-angle glaucoma.

Gene Wiki entry for TMCO1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMCO1 gene promoter:
         AhR   Elk-1   GATA-2   Meis-1b   PPAR-gamma1   Meis-1a   PPAR-gamma2   Pax-4a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMCO1 promoter sequence
   Search Chromatin IP Primers for TMCO1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMCO1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22-q25   Ensembl cytogenetic band:  1q24.1   HGNC cytogenetic band: 1q22-q25

TMCO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMCO1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M165693:  view genomic region     (about GC identifiers)

Start:
165,693,528 bp from pter      End:
165,796,992 bp from pter
Size:
103,465 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TMCO1_HUMAN, Q9UM00 (See protein sequence)
Recommended Name: Transmembrane and coiled-coil domain-containing protein 1  
Size: 188 amino acids; 21175 Da
Sequence caution: Sequence=AAC25388.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAK07514.1; Type=Frameshift; Positions=Several; Sequence=AAK07549.1; Type=Frameshift; Positions=Several;
Secondary accessions: B2REA0 O75545 Q9BZS3 Q9BZU8
Alternative splicing: 2 isoforms:  Q9UM00-1   Q9UM00-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TMCO1: NX_Q9UM00

Explore proteomics data for TMCO1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys116, Lys186
  • Modification sites at PhosphoSitePlus

  • See TMCO1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001243093.1  NP_001243094.1  NP_061899.2  

    ENSEMBL proteins: 
     ENSP00000375975   ENSP00000356856   ENSP00000462588   ENSP00000463951   ENSP00000464127  
     ENSP00000462300   ENSP00000463105  

    TMCO1 Human Recombinant Protein Products:

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    Novus Biologicals TMCO1 Protein
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TMCO1

     
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    antibodies-online proteins for TMCO1 

     
    antibodies-online peptides for TMCO1

    TMCO1 Antibody Products:

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    antibodies-online antibodies for TMCO1 (3 products) 

    TMCO1 Assay Products:

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    antibodies-online kits for TMCO1 (7 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR008559 UCP023322_TM_euk
     IPR002809 DUF106_TM

    Graphical View of Domain Structure for InterPro Entry Q9UM00

    ProtoNet protein and cluster: Q9UM00

    UniProtKB/Swiss-Prot: TMCO1_HUMAN, Q9UM00
    Similarity: Belongs to the TMCO1 family


    Find genes that share domains with TMCO1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TMCO1

    miRNA
    Products:
        
    miRTarBase miRNAs that target TMCO1:
    hsa-mir-30a-5p (MIRT005185)

    Block miRNA regulation of human, mouse, rat TMCO1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TMCO1 (see all 18):
    hsa-miR-485-5p hsa-miR-378b hsa-miR-374a* hsa-miR-186 hsa-miR-155* hsa-miR-378 hsa-miR-548c-3p hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmidTMCO1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TMCO1

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    GenScript: all cDNA clones in your preferred vector: TMCO1 (NM_019026)
    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TMCO1_HUMAN, Q9UM00: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane;
    Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    golgi apparatus5
    extracellular3
    plasma membrane2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TMCO1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMCO1
    Interactions:

        Search GeneGlobe Interaction Network for TMCO1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for TMCO1 (Q9UM003 ENSP000003568564) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GH1P012413, ENSP000003126734I2D: score=1 STRING: ENSP00000312673
    UNC93B1Q9H1C43, ENSP000002274714I2D: score=1 STRING: ENSP00000227471
    TMBIM4Q9HC243, ENSP000003509654I2D: score=1 STRING: ENSP00000350965
    GSTK1Q9Y2Q33I2D: score=1 
    TBC1D24Q9ULP93I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMCO1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TMCO1 gene (3 alternative transcripts): 
    NM_001256164.1  NM_001256165.1  NM_019026.4  

    Unigene Cluster for TMCO1:

    Transmembrane and coiled-coil domains 1
    Hs.31498  [show with all ESTs]
    Unigene Representative Sequence: NM_001256165
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000392129(uc001gdk.4 uc001gdj.4 uc001gdn.4) ENST00000367881
    ENST00000580248 ENST00000464650 ENST00000476143 ENST00000481278 ENST00000465705

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TMCO1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TMCO1 (see all 18):
    hsa-miR-485-5p hsa-miR-378b hsa-miR-374a* hsa-miR-186 hsa-miR-155* hsa-miR-378 hsa-miR-548c-3p hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmidTMCO1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TMCO1
    Predesigned siRNA for gene silencing in human, mouse, rat TMCO1
    Clone
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    OriGene clones in human, mouse for TMCO1 (see all 8)
    OriGene ORF clones in mouse, rat for TMCO1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TMCO1 (NM_019026)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMCO1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMCO1
    Primer
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    OriGene qPCR primer pairs and template standards for TMCO1
    OriGene qSTAR qPCR primer pairs in human, mouse for TMCO1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMCO1
      QuantiTect SYBR Green Assays in human, mouse, rat TMCO1
      QuantiFast Probe-based Assays in human, mouse, rat TMCO1

    Additional mRNA sequence: 

    AB020980.1 AF070626.1 AF274935.1 AF277194.1 AK298614.1 AK316080.1 AK316610.1 AY359027.1 
    AY763589.1 BC000104.2 NR_045818.1 

    24 DOTS entries:

    DT.92458695  DT.91683188  DT.100845495  DT.100845481  DT.451618  DT.100031970  DT.95277973  DT.100845488 
    DT.121359493  DT.40233117  DT.121359658  DT.311719  DT.100845490  DT.121359702  DT.100845494  DT.100044554 
    DT.121359689  DT.121359735  DT.100833035  DT.100845485  DT.121359695  DT.311718  DT.100798708  DT.311720 

    4 AceView cDNA sequences:

    BG231693 BC041651 BM551788 AI140608 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TMCO1 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d
    SP1:                                      -                 -                                                         
    SP2:                                -     -                 -                                                         
    SP3:                                                        -                                                         
    SP4:                                      -                 -                       -                                 
    SP5:                                      -           -     -                                                         


    ECgene alternative splicing isoforms for TMCO1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMCO1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCCAGGAAG
    TMCO1 Expression
    About this image

    TMCO1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMCO1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.31498

    UniProtKB/Swiss-Prot: TMCO1_HUMAN, Q9UM00
    Tissue specificity: Widely expressed in adult and fetal tissues, with higher levels in thymus, prostate, testis
    and small intestine and lower levels in brain, placenta, lung and kidney

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TMCO1 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmco11 , 5 transmembrane and coiled-coil domains 11, 5 90.6(n)1
    100(a)1
      1 (74.69 cM)5
    689441  NM_001039483.11  NP_001034572.11 
     1673086705 
    chicken
    (Gallus gallus)
    Aves TMCO11 transmembrane and coiled-coil domains 1 83.87(n)
    96.81(a)
      427100  XM_424693.4  XP_424693.2 
    lizard
    (Anolis carolinensis)
    Reptilia TMCO16
    transmembrane and coiled-coil domains 1
    93(a)
    1 ↔ 1
    4(73812906-73827466)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.252312 Xenopus laevis transcribed sequence with weak similarity more 78.46(n)    BJ038891.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sbcb7292 sbcb729 77.88(n)   378980  BQ093784.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG104701 CG10470 65.93(n)
    75.82(a)
      35174  NM_136092.2  NP_609936.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F22B5.101 F22B5.10 61.99(n)
    64.04(a)
      174352  NM_063385.5  NP_495786.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G066601 AT5G06660 53.37(n)
    48.88(a)
      830554  NM_120749.2  NP_196284.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g07214001 Os03g0721400 49.72(n)
    44.13(a)
      4333937  NM_001057639.1  NP_001051104.1 


    ENSEMBL Gene Tree for TMCO1 (if available)
    TreeFam Gene Tree for TMCO1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TMCO1 gene
    1 SIMAP similar gene for TMCO1 using alignment to 8 protein entries:     TMCO1_HUMAN (see all proteins):
    C12orf23

    Find genes that share paralogs with TMCO1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMCO1 (see all 1017)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs601856531,2
    C--165695393(+) TTTTC-/TTCATTAT 4 -- cds1 nc-transcript-variant0--------
    rs112988191,2
    C--165698557(+) AATTC-/TTTTTT 4 -- int1 trp31Minor allele frequency- T:0.00NA 2
    rs716569631,2
    C--165699593(+) AAAAC-/AAAAAA 4 -- int11Minor allele frequency- A:0.00CSA 2
    rs794115541,2
    C,F--165700092(+) TCCCAG/AGTGCT 4 -- int13Minor allele frequency- A:0.50WA CSA 6
    rs1133286281,2
    C,F--165700210(+) TGGCTC/TACTGC 4 -- int12Minor allele frequency- T:0.50WA CSA 4
    rs1440653221,2
    C--165702875(+) CTAAA-/AGAT  
            
    AGGAG
    4 -- int10--------
    rs756938371,2
    C--165702877(+) AAAAG-/ATAG  
            
    GAGTT
    4 -- int10--------
    rs730205271,2
    C,F--165703836(+) CCTCCT/CGAGTT 4 -- int14Minor allele frequency- C:0.06WA CSA 124
    rs340624841,2
    C--165704749(+) TTTTT-/TGGAGA 4 -- int12Minor allele frequency- T:0.25NA 4
    rs582540791,2
    C--165705690(+) GCTCA-/ACGCCT 4 -- int11Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for TMCO1 (165693528 - 165796992 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for TMCO1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2719106CNV Deletion23290073
    esv2520993CNV Deletion19546169
    esv2177447CNV Deletion18987734
    esv5064CNV Deletion18987735
    nsv159176CNV Loss16902084
    esv6923CNV Loss19470904
    nsv518886CNV Gain19592680

    Human Gene Mutation Database (HGMD): TMCO1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TMCO1
    DNA2.0 Custom Variant and Variant Library Synthesis for TMCO1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614123   
    OMIM disorders: 614132  
    UniProtKB/Swiss-Prot: TMCO1_HUMAN, Q9UM00
  • Craniofacial dysmorphism, skeletal anomalies and mental retardation syndrome (CFSMR) [MIM:614132]: A
    disorder characterized by craniofacial and skeletal anomalies, associated with mental retardation. Typical
    craniofacial dysmorphism include brachycephaly, highly arched bushy eyebrows, synophrys, long eyelashes, low-set
    ears, microdontism of primary teeth, and generalized gingival hyperplasia, whereas Sprengel deformity of scapula,
    fusion of spine, rib abnormities, pectus excavatum, and pes planus represent skeletal anomalies. Note=The disease
    is caused by mutations affecting the gene represented in this entry

  • 4 diseases for TMCO1:    
    About MalaCards
    craniofacial dysmorphism, skeletal anomalies, and mental retardation syndrome    open-angle glaucoma    cystic nephroma    glaucoma


    Find genes that share disorders with TMCO1           About GenesLikeMe

    Genetic Association Database (GAD): TMCO1
    Human Genome Epidemiology (HuGE) Navigator: TMCO1 (1 document)

    Export disorders for TMCO1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMCO1 gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with TMCO1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Homozygous frameshift mutation in TMCO1 causes a syndrome with craniofacial dysmorphism, skeletal anomalies, and mental retardation. (PubMed id 20018682)1, 2 Xin B.... Wang H. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    2. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PubMed id 19536175)1, 4 Ehret G.B....Chakravarti A. (Eur. J. Hum. Genet. 2009)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    8. Multi-ubiquitination of a nascent membrane protein produced in a rabbit reticulocyte lysate. (PubMed id 10393320)1, 2 Iwamuro S.... Kato S. (J. Biochem. 1999)
    9. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 3 Yu W.... Gibbs R.A. (Genome Res. 1997)
    10. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (Anal. Biochem. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54499 HGNC: 18188 AceView: LOC54499.1 Ensembl:ENSG00000143183 euGenes: HUgn54499
    ECgene: TMCO1 H-InvDB: TMCO1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TMCO1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMCO1 gene:
    Search GeneIP for patents involving TMCO1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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