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Aliases for TMCC3 Gene

Aliases for TMCC3 Gene

  • Transmembrane And Coiled-Coil Domain Family 3 2 3 5
  • Transmembrane And Coiled-Coil Domains 3 2
  • KIAA1145 4

External Ids for TMCC3 Gene

Previous GeneCards Identifiers for TMCC3 Gene

  • GC12M093465
  • GC12M094960
  • GC12M092028

Summaries for TMCC3 Gene

GeneCards Summary for TMCC3 Gene

TMCC3 (Transmembrane And Coiled-Coil Domain Family 3) is a Protein Coding gene. An important paralog of this gene is TMCC2.

Additional gene information for TMCC3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMCC3 Gene

Genomics for TMCC3 Gene

Regulatory Elements for TMCC3 Gene

Enhancers for TMCC3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H094643 1.6 FANTOM5 Ensembl ENCODE dbSUPER 46.3 +6.2 6240 2 SCRT1 CTCF JUN NR2F1 ZNF10 ZEB2 NR2F2 GABPA OSR2 ZNF664 TMCC3 PLXNC1 LOC105369914 GC12P094593
GH12H094171 1.9 FANTOM5 Ensembl ENCODE dbSUPER 33.3 +476.5 476483 5 HDGF PKNOX1 FOXA2 ATF1 ARID4B DMAP1 FOS ATF7 RUNX3 MXD4 PLXNC1 TMCC3 ENSG00000258035 GC12P094149
GH12H094147 1.6 FANTOM5 ENCODE dbSUPER 34.8 +500.0 500021 5 PKNOX1 FOXA2 SIN3A ARID4B FEZF1 DMAP1 YY1 GLIS2 ZNF143 ZNF207 TMCC3 PLXNC1 NR2C1 ENSG00000258365 ENSG00000271382 CRADD GC12P094149 ENSG00000258035
GH12H094674 1.5 FANTOM5 Ensembl ENCODE 30.8 -26.1 -26094 3 ATF1 ZBTB40 YY1 ATF7 ETV6 RUNX3 IKZF2 ZNF362 ZBTB11 ZNF217 TMCC3 GC12M094666 GC12M094805
GH12H094244 1.4 FANTOM5 Ensembl ENCODE 25.7 +405.0 405047 2 HDGF BMI1 ZNF207 ATF7 ETV6 RUNX3 CREM IKZF2 SMARCA5 CBFB PLXNC1 TMCC3 ENSG00000258172 ENSG00000258035
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMCC3 on UCSC Golden Path with GeneCards custom track

Promoters for TMCC3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000055781 462 1800 CTCF MXI1 KLF1 ZNF777 BACH1 ZNF223 ZIC2 RAD21 YY1 ZFHX2

Genomic Location for TMCC3 Gene

94,567,124 bp from pter
94,650,562 bp from pter
83,439 bases
Minus strand

Genomic View for TMCC3 Gene

Genes around TMCC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMCC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMCC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMCC3 Gene

Proteins for TMCC3 Gene

  • Protein details for TMCC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane and coiled-coil domain protein 3
    Protein Accession:
    Secondary Accessions:
    • Q8IWB2

    Protein attributes for TMCC3 Gene

    477 amino acids
    Molecular mass:
    53785 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMCC3 Gene

Post-translational modifications for TMCC3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMCC3 Gene

No data available for DME Specific Peptides for TMCC3 Gene

Domains & Families for TMCC3 Gene

Gene Families for TMCC3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMCC3 Gene


Suggested Antigen Peptide Sequences for TMCC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TEX28 family.
  • Belongs to the TEX28 family.
genes like me logo Genes that share domains with TMCC3: view

Function for TMCC3 Gene

Phenotypes From GWAS Catalog for TMCC3 Gene

Gene Ontology (GO) - Molecular Function for TMCC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24454821
genes like me logo Genes that share ontologies with TMCC3: view
genes like me logo Genes that share phenotypes with TMCC3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMCC3

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMCC3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMCC3 Gene

Localization for TMCC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMCC3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMCC3 gene
Compartment Confidence
plasma membrane 3
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TMCC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMCC3: view

Pathways & Interactions for TMCC3 Gene

SuperPathways for TMCC3 Gene

No Data Available

Interacting Proteins for TMCC3 Gene

Gene Ontology (GO) - Biological Process for TMCC3 Gene


No data available for Pathways by source and SIGNOR curated interactions for TMCC3 Gene

Drugs & Compounds for TMCC3 Gene

No Compound Related Data Available

Transcripts for TMCC3 Gene

Unigene Clusters for TMCC3 Gene

Transmembrane and coiled-coil domain family 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMCC3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TMCC3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1: - - - -
SP2: - -

Relevant External Links for TMCC3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMCC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMCC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMCC3 Gene

This gene is overexpressed in Whole Blood (x5.9).

Protein differential expression in normal tissues from HIPED for TMCC3 Gene

This gene is overexpressed in Pancreatic juice (20.6), Lung (14.3), Testis (10.2), Placenta (7.6), and Stomach (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMCC3 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMCC3 Gene:


SOURCE GeneReport for Unigene cluster for TMCC3 Gene:


mRNA Expression by UniProt/SwissProt for TMCC3 Gene:

Tissue specificity: Widely expressed, with highest levels in brain, spinal cord and testis.

Evidence on tissue expression from TISSUES for TMCC3 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with TMCC3: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMCC3 Gene

Orthologs for TMCC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMCC3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMCC3 33 34
  • 99.51 (n)
(Monodelphis domestica)
Mammalia TMCC3 34
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia TMCC3 34
  • 91 (a)
(Canis familiaris)
Mammalia TMCC3 33 34
  • 89.87 (n)
(Mus musculus)
Mammalia Tmcc3 33 16 34
  • 87.56 (n)
(Rattus norvegicus)
Mammalia Tmcc3 33
  • 87.28 (n)
(Bos Taurus)
Mammalia TMCC3 33 34
  • 86.23 (n)
(Gallus gallus)
Aves TMCC3 33 34
  • 77.35 (n)
(Anolis carolinensis)
Reptilia TMCC3 34
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmcc3 33
  • 74.58 (n)
Str.16809 33
(Danio rerio)
Actinopterygii tmcc3 33 34
  • 62.57 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG1021 34
  • 26 (a)
(Caenorhabditis elegans)
Secernentea C15H9.4 34
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5281 34
  • 41 (a)
Species where no ortholog for TMCC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMCC3 Gene

Gene Tree for TMCC3 (if available)
Gene Tree for TMCC3 (if available)

Paralogs for TMCC3 Gene

Paralogs for TMCC3 Gene

(4) SIMAP similar genes for TMCC3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TMCC3: view

Variants for TMCC3 Gene

Sequence variations from dbSNP and Humsavar for TMCC3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000006456 -- 94,634,474(+) AAACA(C/G)CAACA intron-variant
rs1000009956 -- 94,640,662(+) ATGAC(C/T)GAACT intron-variant
rs1000029770 -- 94,584,648(+) CTCCT(C/T)CACAA intron-variant
rs1000038086 -- 94,626,555(+) CCAAT(A/G)TCAAT intron-variant
rs1000097715 -- 94,646,196(+) ATATG(G/T)AAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMCC3 Gene

Variant ID Type Subtype PubMed ID
esv3580378 CNV loss 25503493
esv3630420 CNV loss 21293372
nsv507666 OTHER sequence alteration 20534489
nsv7234 OTHER inversion 18451855

Variation tolerance for TMCC3 Gene

Residual Variation Intolerance Score: 43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.14; 51.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMCC3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMCC3 Gene

Disorders for TMCC3 Gene

Relevant External Links for TMCC3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMCC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMCC3 Gene

Publications for TMCC3 Gene

  1. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4 60
  2. Expression and characterization of transmembrane and coiled-coil domain family 3. (PMID: 27697108) Sohn WJ … Kwon HJ (BMB reports 2016) 3 4 60
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for TMCC3 Gene

Sources for TMCC3 Gene

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