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Aliases for TMCC3 Gene

Aliases for TMCC3 Gene

  • Transmembrane And Coiled-Coil Domain Family 3 2 3 5
  • Transmembrane And Coiled-Coil Domains 3 2
  • KIAA1145 4

External Ids for TMCC3 Gene

Previous GeneCards Identifiers for TMCC3 Gene

  • GC12M093465
  • GC12M094960
  • GC12M092028

Summaries for TMCC3 Gene

GeneCards Summary for TMCC3 Gene

TMCC3 (Transmembrane And Coiled-Coil Domain Family 3) is a Protein Coding gene. An important paralog of this gene is TMCC2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMCC3 Gene

Genomics for TMCC3 Gene

Regulatory Elements for TMCC3 Gene

Enhancers for TMCC3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F094643 1.4 FANTOM5 Ensembl ENCODE 46.3 +6.2 6162 2.4 SCRT1 CTCF JUN ZEB2 NR2F2 ZNF664 OSR2 SCRT2 IKZF1 SP7 TMCC3 PLXNC1 LOC105369914 GC12P094593
GH12F094147 0.9 FANTOM5 ENCODE 34.8 +500.0 500021 5.9 PKNOX1 WRNIP1 SIN3A ARID4B FEZF1 DMAP1 ZNF48 YY1 GLIS2 ZNF143 TMCC3 PLXNC1 ENSG00000258365 ENSG00000271382 CRADD GC12P094149 ENSG00000258035
GH12F094171 1.2 FANTOM5 Ensembl ENCODE 33.3 +476.4 476389 5.3 HDGF PKNOX1 ATF1 ARID4B FEZF1 DMAP1 FOS JUNB MXD4 REST PLXNC1 TMCC3 ENSG00000258035 GC12P094149
GH12F094673 1.5 FANTOM5 Ensembl ENCODE 30.8 -25.6 -25591 6.1 ATF1 DMAP1 ZNF121 TBX21 PPARG KAT8 MIER3 MXD3 NBN CTCF TMCC3 MIR7844 GC12M094666 GC12M094805
GH12F094244 1.2 FANTOM5 Ensembl ENCODE 25.7 +405.0 405047 2.7 HDGF BMI1 YY1 RARA CBX5 ETV6 CREM EGR2 SMAD5 CBFB PLXNC1 TMCC3 ENSG00000258172 ENSG00000258035
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TMCC3 on UCSC Golden Path with GeneCards custom track

Promoters for TMCC3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000173698 762 2400 CTCF KLF1 ZNF223 ZIC2 RAD21 ZFHX2 GATA3 POLR2A SCRT2 ZNF600

Genomic Location for TMCC3 Gene

Chromosome:
12
Start:
94,567,124 bp from pter
End:
94,650,562 bp from pter
Size:
83,439 bases
Orientation:
Minus strand

Genomic View for TMCC3 Gene

Genes around TMCC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMCC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMCC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMCC3 Gene

Proteins for TMCC3 Gene

  • Protein details for TMCC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULS5-TMCC3_HUMAN
    Recommended name:
    Transmembrane and coiled-coil domains protein 3
    Protein Accession:
    Q9ULS5
    Secondary Accessions:
    • Q8IWB2

    Protein attributes for TMCC3 Gene

    Size:
    477 amino acids
    Molecular mass:
    53785 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMCC3 Gene

Post-translational modifications for TMCC3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMCC3 Gene

No data available for DME Specific Peptides for TMCC3 Gene

Domains & Families for TMCC3 Gene

Gene Families for TMCC3 Gene

Protein Domains for TMCC3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMCC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9ULS5

UniProtKB/Swiss-Prot:

TMCC3_HUMAN :
  • Belongs to the TEX28 family.
Family:
  • Belongs to the TEX28 family.
genes like me logo Genes that share domains with TMCC3: view

Function for TMCC3 Gene

genes like me logo Genes that share phenotypes with TMCC3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMCC3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMCC3 Gene

Localization for TMCC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMCC3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMCC3 Gene COMPARTMENTS Subcellular localization image for TMCC3 gene
Compartment Confidence
plasma membrane 3
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for TMCC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMCC3: view

Pathways & Interactions for TMCC3 Gene

SuperPathways for TMCC3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMCC3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMCC3 Gene

Transcripts for TMCC3 Gene

Unigene Clusters for TMCC3 Gene

Transmembrane and coiled-coil domain family 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMCC3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1: - - - -
SP2: - -
SP3:

Relevant External Links for TMCC3 Gene

GeneLoc Exon Structure for
TMCC3
ECgene alternative splicing isoforms for
TMCC3

Expression for TMCC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMCC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMCC3 Gene

This gene is overexpressed in Whole Blood (x5.9).

Protein differential expression in normal tissues from HIPED for TMCC3 Gene

This gene is overexpressed in Pancreatic juice (20.6), Lung (14.3), Testis (10.2), Placenta (7.6), and Stomach (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMCC3 Gene



NURSA nuclear receptor signaling pathways regulating expression of TMCC3 Gene:

TMCC3

SOURCE GeneReport for Unigene cluster for TMCC3 Gene:

Hs.370410
genes like me logo Genes that share expression patterns with TMCC3: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TMCC3 Gene

Orthologs for TMCC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMCC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMCC3 34 35
  • 99.51 (n)
oppossum
(Monodelphis domestica)
Mammalia TMCC3 35
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMCC3 35
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMCC3 34 35
  • 89.87 (n)
mouse
(Mus musculus)
Mammalia Tmcc3 34 16 35
  • 87.56 (n)
rat
(Rattus norvegicus)
Mammalia Tmcc3 34
  • 87.28 (n)
cow
(Bos Taurus)
Mammalia TMCC3 34 35
  • 86.23 (n)
chicken
(Gallus gallus)
Aves TMCC3 34 35
  • 77.35 (n)
lizard
(Anolis carolinensis)
Reptilia TMCC3 35
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmcc3 34
  • 74.58 (n)
Str.16809 34
zebrafish
(Danio rerio)
Actinopterygii tmcc3 34 35
  • 62.57 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG1021 35
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C15H9.4 35
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5281 35
  • 41 (a)
OneToMany
Species where no ortholog for TMCC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMCC3 Gene

ENSEMBL:
Gene Tree for TMCC3 (if available)
TreeFam:
Gene Tree for TMCC3 (if available)

Paralogs for TMCC3 Gene

Paralogs for TMCC3 Gene

(4) SIMAP similar genes for TMCC3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TMCC3: view

Variants for TMCC3 Gene

Sequence variations from dbSNP and Humsavar for TMCC3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10219601 -- 94,597,802(+) GCTCT(A/G)TCTCA intron-variant
rs10400518 -- 94,651,990(+) AAAAC(A/G)CACTG upstream-variant-2KB
rs10466949 -- 94,614,349(+) ACACA(C/G)AGGAA intron-variant
rs10466950 -- 94,614,351(+) ACACA(A/G)GAATG intron-variant
rs10466990 -- 94,614,055(+) gcacc(A/G)ctgca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMCC3 Gene

Variant ID Type Subtype PubMed ID
esv3580378 CNV loss 25503493
esv3630420 CNV loss 21293372
nsv507666 OTHER sequence alteration 20534489
nsv7234 OTHER inversion 18451855

Variation tolerance for TMCC3 Gene

Residual Variation Intolerance Score: 43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.14; 51.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMCC3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMCC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMCC3 Gene

Disorders for TMCC3 Gene

Relevant External Links for TMCC3

Genetic Association Database (GAD)
TMCC3
Human Genome Epidemiology (HuGE) Navigator
TMCC3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMCC3

No disorders were found for TMCC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMCC3 Gene

Publications for TMCC3 Gene

  1. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. A three-stage genome-wide association study of general cognitive ability: hunting the small effects. (PMID: 20306291) Davis O.S. … Plomin R. (Behav. Genet. 2010) 3 64
  5. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3 64

Products for TMCC3 Gene

Sources for TMCC3 Gene

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