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Aliases for TMCC3 Gene

Aliases for TMCC3 Gene

  • Transmembrane And Coiled-Coil Domain Family 3 2 3
  • Transmembrane And Coiled-Coil Domains 3 2
  • KIAA1145 4

External Ids for TMCC3 Gene

Summaries for TMCC3 Gene

GeneCards Summary for TMCC3 Gene

TMCC3 (Transmembrane And Coiled-Coil Domain Family 3) is a Protein Coding gene. An important paralog of this gene is TMCC2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMCC3 Gene

Genomics for TMCC3 Gene

Genomic Location for TMCC3 Gene

Start:
94,567,124 bp from pter
End:
94,650,562 bp from pter
Size:
83,439 bases
Orientation:
Minus strand

Genomic View for TMCC3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMCC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMCC3 Gene

Regulatory Elements for TMCC3 Gene

Proteins for TMCC3 Gene

  • Protein details for TMCC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULS5-TMCC3_HUMAN
    Recommended name:
    Transmembrane and coiled-coil domains protein 3
    Protein Accession:
    Q9ULS5
    Secondary Accessions:
    • Q8IWB2

    Protein attributes for TMCC3 Gene

    Size:
    477 amino acids
    Molecular mass:
    53785 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMCC3 Gene

Proteomics data for TMCC3 Gene at MOPED

Post-translational modifications for TMCC3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMCC3 Gene

No data available for DME Specific Peptides for TMCC3 Gene

Domains for TMCC3 Gene

Gene Families for TMCC3 Gene

HGNC:
  • TMCC :Transmembrane and coiled-coil domain containing

Protein Domains for TMCC3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMCC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9ULS5

UniProtKB/Swiss-Prot:

TMCC3_HUMAN
Family:
  • Belongs to the TEX28 family.:
    • Q9ULS5
genes like me logo Genes that share domains with TMCC3: view

Function for TMCC3 Gene

miRNA for TMCC3 Gene

miRTarBase miRNAs that target TMCC3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMCC3 Gene

Localization for TMCC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMCC3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMCC3 Gene COMPARTMENTS Subcellular localization image for TMCC3 gene
Compartment Confidence
plasma membrane 3
nucleus 2
cytosol 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TMCC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMCC3: view

Pathways for TMCC3 Gene

SuperPathways for TMCC3 Gene

No Data Available

Interacting Proteins for TMCC3 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000261226%0d%0a9606.ENSP00000243776%0d%0a9606.ENSP00000035307%0d%0a
Selected Interacting proteins: ENSP00000261226 for TMCC3 Gene via STRING

Gene Ontology (GO) - Biological Process for TMCC3 Gene

None

No data available for Pathways by source for TMCC3 Gene

Transcripts for TMCC3 Gene

mRNA/cDNA for TMCC3 Gene

Unigene Clusters for TMCC3 Gene

Transmembrane and coiled-coil domain family 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMCC3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1: - - - -
SP2: - -
SP3:

Relevant External Links for TMCC3 Gene

GeneLoc Exon Structure for
TMCC3
ECgene alternative splicing isoforms for
TMCC3

Expression for TMCC3 Gene

mRNA expression in normal human tissues for TMCC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMCC3 Gene

This gene is overexpressed in Whole Blood (5.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMCC3 Gene

SOURCE GeneReport for Unigene cluster for TMCC3 Gene Hs.370410

genes like me logo Genes that share expressions with TMCC3: view

No data available for mRNA Expression by UniProt/SwissProt for TMCC3 Gene

Orthologs for TMCC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMCC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMCC3 35
  • 99.51 (n)
  • 100 (a)
TMCC3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMCC3 35
  • 86.23 (n)
  • 92.87 (a)
TMCC3 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMCC3 35
  • 89.87 (n)
  • 94.46 (a)
TMCC3 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmcc3 35
  • 87.56 (n)
  • 94.13 (a)
Tmcc3 16
Tmcc3 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMCC3 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMCC3 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmcc3 35
  • 87.28 (n)
  • 95.18 (a)
chicken
(Gallus gallus)
Aves TMCC3 35
  • 77.35 (n)
  • 86.2 (a)
TMCC3 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMCC3 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16809 35
tmcc3 35
  • 74.58 (n)
  • 81.57 (a)
zebrafish
(Danio rerio)
Actinopterygii tmcc3 35
  • 62.57 (n)
  • 61.05 (a)
tmcc3 36
  • 56 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG1021 36
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C15H9.4 36
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5281 36
  • 41 (a)
OneToMany
Species with no ortholog for TMCC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMCC3 Gene

ENSEMBL:
Gene Tree for TMCC3 (if available)
TreeFam:
Gene Tree for TMCC3 (if available)

Paralogs for TMCC3 Gene

Paralogs for TMCC3 Gene

Selected SIMAP similar genes for TMCC3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TMCC3: view

Variants for TMCC3 Gene

Sequence variations from dbSNP and Humsavar for TMCC3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs954959 -- 94,620,983(-) GTGTT(C/G)TTTTT intron-variant
rs954960 -- 94,620,726(-) GCCTA(A/G)TTTTT intron-variant
rs1064496 -- 94,569,292(-) GGGCA(C/T)CAGAC utr-variant-3-prime
rs1274519 -- 94,634,849(-) ACTAT(G/T)TGTTG intron-variant
rs1274520 -- 94,632,990(-) TAACG(A/G)GGACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMCC3 Gene

Variant ID Type Subtype PubMed ID
nsv7234 OTHER Inversion 18451855
nsv507666 CNV Insertion 20534489
nsv899444 CNV Gain 21882294

Relevant External Links for TMCC3 Gene

HapMap Linkage Disequilibrium report
TMCC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMCC3 Gene

Disorders for TMCC3 Gene

Relevant External Links for TMCC3

Genetic Association Database (GAD)
TMCC3
Human Genome Epidemiology (HuGE) Navigator
TMCC3
genes like me logo Genes that share disorders with TMCC3: view

No data available for UniProtKB/Swiss-Prot for TMCC3 Gene

Publications for TMCC3 Gene

  1. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3
  5. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 4

Products for TMCC3 Gene

Sources for TMCC3 Gene

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