TMCC3 Gene
protein-coding GIFtS : 43
GCID: GC12 M094960
transmembrane and coiled-coil domain family 3 (Previous name: transmembrane and coiled-coil domains 3 )
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Aliasesfor TMCC3 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Transmembrane And Coiled-Coil Domain Family 3 1 2 Transmembrane And Coiled-Coil Domains 31 2 KIAA11451 3 Transmembrane And Coiled-Coil Domains Protein 32
Export aliases for TMCC3 gene to outside databases Previous GC identifers: GC12M093465 GC12M092028
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Summariesfor TMCC3 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor TMCC3 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000012.11 NC_018923.1 NT_029419.12 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TMCC3 gene promoter: NF-1/L NF-1 Pax-5 FOXO3 MyoD STAT5A FOXO3b FOXO4 FOXO3a Other transcription factors Search SABiosciences Chromatin IP Primers for TMCC3 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat TMCC3
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 12q22 Ensembl cytogenetic band: 12q22 HGNC cytogenetic band: 12q22 TMCC3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 12 GeneLoc Exon Structure
GeneLoc location for GC12M094960: view genomic region
(about GC identifiers )
Start:
94,960,900 bp from pter
End:
95,044,338 bp from pter
Size:
83,439 bases
Orientation:
minus strand
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Proteinsfor TMCC3 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: TMCC3_HUMAN, Q9ULS5 (See
protein sequence )Recommended Name: Transmembrane and coiled-coil domains protein 3 Size : 477 amino acids; 53785 Da
Subcellular location : Membrane; Multi-pass membrane protein (Potential)
Secondary accessions : Q8IWB2Explore the universe of human proteins at neXtProt for TMCC3: NX_Q9ULS5 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9ULS5 TMCC3 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_065749.2 ENSEMBL proteins: ENSP00000261226 ENSP00000449888 ENSP00000450078 Human Recombinant Protein Products for TMCC3: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0016021 integral to membrane
IEA --
TMCC3 for ontologies About GeneDecksing TMCC3 Antibody Products: Assay Products for TMCC3:
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Protein
Domains / Familiesfor TMCC3 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
TMCC3 for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q9ULS5 ProtoNet protein and cluster: Q9ULS5
UniProtKB/Swiss-Prot: TMCC3_HUMAN, Q9ULS5 Similarity : Belongs to the TEX28 family
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Functionfor TMCC3 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Animal Models: Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TMCC3 (see all 6 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TMCC3OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TMCC3 (NM_020698 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMCC3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TMCC3
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMCC3
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Pathways & Interactionsfor TMCC3 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMCC3
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Drugs & Compoundsfor TMCC3 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for TMCC3 Search CenterWatch for drugs/clinical trials and news about TMCC3
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Transcriptsfor TMCC3 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
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SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for TMCC3 gene: NM_020698.2 Unigene Cluster for TMCC3:
Transmembrane and coiled-coil domain family 3 Hs.370410 [show with all ESTs ] Unigene Representative Sequence: NM_020698 4 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000261226 (uc001tdi.2 uc001tdj.2 ) ENST00000551457 ENST00000548918 ENST00000552239 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TMCC3 (see all 6 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TMCC3OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TMCC3 (NM_020698 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMCC3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TMCC3
Additional cDNA sequence: AB032971.1 AB073655.1 BC040535.1
4 DOTS entries : DT.110475 DT.100777026
DT.121156019 DT.100662041 24/107 AceView cDNA sequences (see all 107 ):
BQ778054 T32874 BU952590 AI279253 BQ025083 AW024937 BF433078 AA318843 AI601145 CA771998 BQ777749 BM876167 BU751975 AW954349 CB156294 CR620972 AA515537 BE219769 BQ024175 BF971213 AI003069 AA253339 AA505358 CK824030 GeneLoc Exon Structure 3 Alternative Splicing Database (ASD) splice patterns (SP) for TMCC3 About this scheme ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 SP1 :   -   -   -   -         SP2 :       -   -         SP3 :                
ECgene alternative splicing isoforms for TMCC3
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Expression for TMCC3 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section TMCC3 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TCAGCCTAAAAbout this image TMCC3 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
See TMCC3 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TMCC3 SOURCE GeneReport for Unigene cluster: Hs.370410 SABiosciences Custom PCR Arrays for TMCC3 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TMCC3Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat TMCC3 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TMCC3 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TMCC3 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMCC3
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Orthologsfor TMCC3 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for TMCC3 gene from 7/18 species (see all 18 ) About this table
ENSEMBL Gene Tree for TMCC3 (if available)TreeFam Gene Tree for TMCC3 (if available)
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Paralogsfor TMCC3 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for TMCC3 gene TEX28P1 2 TMCC1 2 TEX28P2 2 TEX28 2 TMCC2 2 4 SIMAP similar genes for TMCC3 using alignment to 3 protein entries: TMCC3_HUMAN (see all proteins ):TMCC2 TMCC1 DKFZp686H13261 TEX28
TMCC3 for paralogs About GeneDecksing
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Genomic Variantsfor TMCC3 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 12 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for TMCC3 (94960900 - 95044338 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for TMCC3: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TMCC3
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Disorders
/ Diseasesfor TMCC3 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section TMCC3 for disorders About MalaCards
TMCC3 for disorders About GeneDecksing Human Genome Epidemiology (HuGE) Navigator: TMCC3 (2 documents) Export disorders for TMCC3 gene to outside databases
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Publicationsfor TMCC3 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for TMCC3 gene integrated from 9 sources : (articles sorted by number of sources associating them with TMCC3) Utopia : connect your pdf to the dynamic world of online information
Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461) 1 , 2 , 3 Hirosawa M.... Ohara O. (1999) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614) 1 Rose J.E....Uhl G.R. (2010) A Three-Stage Genome-Wide Association Study of Genera l Cognitive Ability: Hunting the Small Effects. (PubMed id 20306291) 1 Davis O.S....Plomin R. (2010) Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461) 1 Bennett E.J....Harper J.W. (2010) The finished DNA sequence of human chromosome 12. (PubMed id 16541075) 2 Scherer S.E.... Gibbs R.A. (2006) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800) 1 Dias Neto E....Simpson A.J.G. (2000) Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462) 1 Nagase T.... Ohara O. (1999)
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External Searches for TMCC3 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing TMCC3 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing TMCC3 gene
(According to HUGE )
About This Section
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Specialized Databases showing TMCC3 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for TMCC3 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for TMCC3 gene: Search GeneIP for patents involving TMCC3 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor TMCC3 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies OriGene shRNA RFP for TMCC3 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for TMCC3 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TMCC3 OriGene Protein Over-expression Lysate for TMCC3 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for TMCC3 OriGene 3'-UTR Clone for TMCC3 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TMCC3 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TMCC3 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for TMCC3 OriGene Custom Protein Services for TMCC3 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMCC3 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TMCC3 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat TMCC3 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat TMCC3 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TMCC3 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TMCC3
Search Tocris compounds for TMCC3
TMCC3 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMCC3
Search ThermoFisher Antibodies for TMCC3
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TMCC3
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Summaries for TMCC3
Transcripts for TMCC3
Variants for TMCC3
TOP
BOTTOM