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Aliases for TMCC3 Gene

Aliases for TMCC3 Gene

  • Transmembrane And Coiled-Coil Domain Family 3 2 3 5
  • Transmembrane And Coiled-Coil Domains 3 2
  • KIAA1145 4

External Ids for TMCC3 Gene

Previous GeneCards Identifiers for TMCC3 Gene

  • GC12M093465
  • GC12M094960
  • GC12M092028

Summaries for TMCC3 Gene

GeneCards Summary for TMCC3 Gene

TMCC3 (Transmembrane And Coiled-Coil Domain Family 3) is a Protein Coding gene. An important paralog of this gene is TMCC2.

Additional gene information for TMCC3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMCC3 Gene

Genomics for TMCC3 Gene

GeneHancer (GH) Regulatory Elements for TMCC3 Gene

Promoters and enhancers for TMCC3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I094648 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 573.6 +0.8 763 2.7 FOXA2 RAD21 YY1 ZNF335 GLIS2 ZSCAN5C SCRT2 FOS EGR2 ZNF680 TMCC3 LOC105369914
GH12I094614 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 565.7 +31.5 31512 10 PKNOX1 ATF1 ARNT FEZF1 IRF4 YY1 TCF12 GLIS2 GATA2 ZNF207 TMCC3 PLXNC1 GC12P094593 LOC105369914
GH12I094147 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 34.8 +500.0 500020 5.9 PKNOX1 FOXA2 ARID4B FEZF1 DMAP1 YY1 ZNF207 ZNF143 SP3 SP5 PLXNC1 GC12P094149 TMCC3 NR2C1 ENSG00000258365 ENSG00000271382 CRADD ENSG00000258035
GH12I094643 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 46.3 +6.2 6239 2.2 CTCF ZNF449 JUN ZNF664 SCRT2 RUNX3 SCRT1 RXRA ZNF10 NR2F1 TMCC3 PLXNC1 LOC105369914 GC12P094593
GH12I094171 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 33.3 +476.5 476483 5.1 HDGF PKNOX1 FOXA2 ARID4B DMAP1 ETS1 ATF7 FOS RUNX3 JUNB PLXNC1 TMCC3 ENSG00000258035 GC12P094149
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMCC3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMCC3 gene promoter:

Genomic Locations for TMCC3 Gene

Genomic Locations for TMCC3 Gene
chr12:94,567,124-94,650,562
(GRCh38/hg38)
Size:
83,439 bases
Orientation:
Minus strand
chr12:94,960,900-95,044,338
(GRCh37/hg19)

Genomic View for TMCC3 Gene

Genes around TMCC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMCC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMCC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMCC3 Gene

Proteins for TMCC3 Gene

  • Protein details for TMCC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULS5-TMCC3_HUMAN
    Recommended name:
    Transmembrane and coiled-coil domain protein 3
    Protein Accession:
    Q9ULS5
    Secondary Accessions:
    • Q8IWB2

    Protein attributes for TMCC3 Gene

    Size:
    477 amino acids
    Molecular mass:
    53785 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMCC3 Gene

Post-translational modifications for TMCC3 Gene

No Post-translational modifications

Other Protein References for TMCC3 Gene

Antibody Products

  • Abcam antibodies for TMCC3

No data available for DME Specific Peptides for TMCC3 Gene

Domains & Families for TMCC3 Gene

Gene Families for TMCC3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMCC3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMCC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9ULS5

UniProtKB/Swiss-Prot:

TMCC3_HUMAN :
  • Belongs to the TEX28 family.
Family:
  • Belongs to the TEX28 family.
genes like me logo Genes that share domains with TMCC3: view

Function for TMCC3 Gene

Phenotypes From GWAS Catalog for TMCC3 Gene

Gene Ontology (GO) - Molecular Function for TMCC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24454821
genes like me logo Genes that share ontologies with TMCC3: view
genes like me logo Genes that share phenotypes with TMCC3: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMCC3 Gene

Localization for TMCC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMCC3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMCC3 gene
Compartment Confidence
plasma membrane 3
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMCC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMCC3: view

Pathways & Interactions for TMCC3 Gene

SuperPathways for TMCC3 Gene

No Data Available

Interacting Proteins for TMCC3 Gene

Gene Ontology (GO) - Biological Process for TMCC3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMCC3 Gene

Drugs & Compounds for TMCC3 Gene

No Compound Related Data Available

Transcripts for TMCC3 Gene

Unigene Clusters for TMCC3 Gene

Transmembrane and coiled-coil domain family 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMCC3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1: - - - -
SP2: - -
SP3:

Relevant External Links for TMCC3 Gene

GeneLoc Exon Structure for
TMCC3
ECgene alternative splicing isoforms for
TMCC3

Expression for TMCC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMCC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMCC3 Gene

This gene is overexpressed in Whole Blood (x5.9).

Protein differential expression in normal tissues from HIPED for TMCC3 Gene

This gene is overexpressed in Pancreatic juice (20.6), Lung (14.3), Testis (10.2), Placenta (7.6), and Stomach (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMCC3 Gene



NURSA nuclear receptor signaling pathways regulating expression of TMCC3 Gene:

TMCC3

SOURCE GeneReport for Unigene cluster for TMCC3 Gene:

Hs.370410

mRNA Expression by UniProt/SwissProt for TMCC3 Gene:

Q9ULS5-TMCC3_HUMAN
Tissue specificity: Widely expressed, with highest levels in brain, spinal cord and testis.

Evidence on tissue expression from TISSUES for TMCC3 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with TMCC3: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMCC3 Gene

Orthologs for TMCC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMCC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMCC3 33 34
  • 99.51 (n)
oppossum
(Monodelphis domestica)
Mammalia TMCC3 34
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMCC3 34
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMCC3 33 34
  • 89.87 (n)
mouse
(Mus musculus)
Mammalia Tmcc3 33 16 34
  • 87.56 (n)
rat
(Rattus norvegicus)
Mammalia Tmcc3 33
  • 87.28 (n)
cow
(Bos Taurus)
Mammalia TMCC3 33 34
  • 86.23 (n)
chicken
(Gallus gallus)
Aves TMCC3 33 34
  • 77.35 (n)
lizard
(Anolis carolinensis)
Reptilia TMCC3 34
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmcc3 33
  • 74.58 (n)
Str.16809 33
zebrafish
(Danio rerio)
Actinopterygii tmcc3 33 34
  • 62.57 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG1021 34
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C15H9.4 34
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5281 34
  • 41 (a)
OneToMany
Species where no ortholog for TMCC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMCC3 Gene

ENSEMBL:
Gene Tree for TMCC3 (if available)
TreeFam:
Gene Tree for TMCC3 (if available)

Paralogs for TMCC3 Gene

Paralogs for TMCC3 Gene

(4) SIMAP similar genes for TMCC3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TMCC3: view

Variants for TMCC3 Gene

Sequence variations from dbSNP and Humsavar for TMCC3 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000006456 -- 94,634,474(-) G/C genic_upstream_transcript_variant, intron_variant
rs1000009956 -- 94,640,662(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000029770 -- 94,584,648(-) C/T intron_variant
rs1000038086 -- 94,626,555(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000097715 -- 94,646,196(-) G/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMCC3 Gene

Variant ID Type Subtype PubMed ID
esv3580378 CNV loss 25503493
esv3630420 CNV loss 21293372
nsv507666 OTHER sequence alteration 20534489
nsv7234 OTHER inversion 18451855

Variation tolerance for TMCC3 Gene

Residual Variation Intolerance Score: 43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.14; 51.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMCC3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMCC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMCC3 Gene

Disorders for TMCC3 Gene

Additional Disease Information for TMCC3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TMCC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMCC3 Gene

Publications for TMCC3 Gene

  1. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4 58
  2. Expression and characterization of transmembrane and coiled-coil domain family 3. (PMID: 27697108) Sohn WJ … Kwon HJ (BMB reports 2016) 3 4 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for TMCC3 Gene

Sources for TMCC3 Gene

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