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Aliases for TMCC2 Gene

Aliases for TMCC2 Gene

  • Transmembrane And Coiled-Coil Domain Family 2 2 3 5
  • Cerebral Protein 11 3 4
  • Transmembrane And Coiled-Coil Domains 2 2
  • KIAA0481 4
  • HUCEP11 3

External Ids for TMCC2 Gene

Previous GeneCards Identifiers for TMCC2 Gene

  • GC01P201929
  • GC01P203463
  • GC01P176362

Summaries for TMCC2 Gene

GeneCards Summary for TMCC2 Gene

TMCC2 (Transmembrane And Coiled-Coil Domain Family 2) is a Protein Coding gene. An important paralog of this gene is TEX28.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMCC2 Gene

Genomics for TMCC2 Gene

Regulatory Elements for TMCC2 Gene

Promoters for TMCC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMCC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMCC2 Gene

205,227,910 bp from pter
205,273,343 bp from pter
45,434 bases
Plus strand

Genomic View for TMCC2 Gene

Genes around TMCC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMCC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMCC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMCC2 Gene

Proteins for TMCC2 Gene

  • Protein details for TMCC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane and coiled-coil domains protein 2
    Protein Accession:
    Secondary Accessions:
    • A2RRH3
    • B7Z1P7
    • Q6ZN09

    Protein attributes for TMCC2 Gene

    709 amino acids
    Molecular mass:
    77449 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA32326.3; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TMCC2 Gene


neXtProt entry for TMCC2 Gene

Proteomics data for TMCC2 Gene at MOPED

Post-translational modifications for TMCC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMCC2 Gene

Domains & Families for TMCC2 Gene

Gene Families for TMCC2 Gene

Protein Domains for TMCC2 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TEX28 family.
  • Belongs to the TEX28 family.
genes like me logo Genes that share domains with TMCC2: view

Function for TMCC2 Gene

Phenotypes for TMCC2 Gene

genes like me logo Genes that share phenotypes with TMCC2: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMCC2 Gene

Localization for TMCC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMCC2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMCC2 Gene COMPARTMENTS Subcellular localization image for TMCC2 gene
Compartment Confidence
nucleus 3
plasma membrane 3

No data available for Gene Ontology (GO) - Cellular Components for TMCC2 Gene

Pathways & Interactions for TMCC2 Gene

SuperPathways for TMCC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMCC2 Gene


No data available for Pathways by source and SIGNOR curated interactions for TMCC2 Gene

Drugs & Compounds for TMCC2 Gene

No Compound Related Data Available

Transcripts for TMCC2 Gene

Unigene Clusters for TMCC2 Gene

Transmembrane and coiled-coil domain family 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMCC2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b
SP1: - - - - - - -
SP2: - - - -
SP3: - -
SP4: -
SP5: - - -

Relevant External Links for TMCC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMCC2 Gene

mRNA expression in normal human tissues for TMCC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMCC2 Gene

This gene is overexpressed in Whole Blood (x4.8) and Brain - Spinal cord (cervical c-1) (x4.4).

Protein differential expression in normal tissues from HIPED for TMCC2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (37.1) and Plasma (11.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMCC2 Gene

SOURCE GeneReport for Unigene cluster for TMCC2 Gene Hs.6360

genes like me logo Genes that share expression patterns with TMCC2: view

Protein tissue co-expression partners for TMCC2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TMCC2 Gene

Orthologs for TMCC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMCC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMCC2 35
  • 88.71 (n)
  • 89.71 (a)
TMCC2 36
  • 92 (a)
(Canis familiaris)
Mammalia TMCC2 35
  • 92.3 (n)
  • 96.88 (a)
TMCC2 36
  • 95 (a)
(Mus musculus)
Mammalia Tmcc2 35
  • 88.54 (n)
  • 94.18 (a)
Tmcc2 16
Tmcc2 36
  • 95 (a)
(Pan troglodytes)
Mammalia TMCC2 35
  • 99.15 (n)
  • 99.44 (a)
TMCC2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Tmcc2 35
  • 88.49 (n)
  • 93.89 (a)
(Monodelphis domestica)
Mammalia TMCC2 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia TMCC2 36
  • 79 (a)
(Gallus gallus)
Aves TMCC2 35
  • 80.31 (n)
  • 83.92 (a)
TMCC2 36
  • 84 (a)
(Anolis carolinensis)
Reptilia TMCC2 36
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmcc2 35
  • 68.25 (n)
  • 75.22 (a)
(Danio rerio)
Actinopterygii tmcc2 35
  • 77.95 (n)
  • 77.65 (a)
tmcc2 36
  • 77 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1021 36
  • 35 (a)
(Caenorhabditis elegans)
Secernentea C15H9.4 36
  • 23 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5750 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5281 36
  • 50 (a)
Species with no ortholog for TMCC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMCC2 Gene

Gene Tree for TMCC2 (if available)
Gene Tree for TMCC2 (if available)

Paralogs for TMCC2 Gene

Paralogs for TMCC2 Gene

(4) SIMAP similar genes for TMCC2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TMCC2: view

Variants for TMCC2 Gene

Sequence variations from dbSNP and Humsavar for TMCC2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs17728 -- 205,272,531(+) GGTTT(C/T)CTCTG utr-variant-3-prime
rs748011 -- 205,247,489(-) GCCAC(A/G)CCCAT intron-variant
rs748012 -- 205,247,445(-) TGCAA(C/T)TGAAG intron-variant
rs896322 -- 205,240,617(-) GAACA(C/T)CTATC intron-variant, upstream-variant-2KB
rs983337 -- 205,227,360(-) ACACA(A/G)TAACG upstream-variant-2KB

Variation tolerance for TMCC2 Gene

Residual Variation Intolerance Score: 16.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.14; 61.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMCC2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMCC2 Gene

Disorders for TMCC2 Gene

Relevant External Links for TMCC2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMCC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMCC2 Gene

Publications for TMCC2 Gene

  1. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PMID: 9455484) Seki N. … Ohara O. (DNA Res. 1997) 2 3 4 67
  2. A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects. (PMID: 24026423) Shameer K. … Kullo I.J. (Hum. Genet. 2014) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. The impact of a novel apolipoprotein E and amyloid-I^ protein precursor-interacting protein on the production of amyloid-I^. (PMID: 21593558) Hopkins P.C. … Lovestone S. (J. Alzheimers Dis. 2011) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for TMCC2 Gene

Sources for TMCC2 Gene

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