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Aliases for TMCC2 Gene

Aliases for TMCC2 Gene

  • Transmembrane And Coiled-Coil Domain Family 2 2 3
  • Cerebral Protein 11 3 4
  • Transmembrane And Coiled-Coil Domains Protein 2 3
  • Transmembrane And Coiled-Coil Domains 2 2
  • KIAA0481 4
  • HUCEP11 3

External Ids for TMCC2 Gene

Previous GeneCards Identifiers for TMCC2 Gene

  • GC01P201929
  • GC01P203463
  • GC01P176362

Summaries for TMCC2 Gene

GeneCards Summary for TMCC2 Gene

TMCC2 (Transmembrane And Coiled-Coil Domain Family 2) is a Protein Coding gene. An important paralog of this gene is TMCC1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMCC2 Gene

Genomics for TMCC2 Gene

Regulatory Elements for TMCC2 Gene

Genomic Location for TMCC2 Gene

Start:
205,227,910 bp from pter
End:
205,273,343 bp from pter
Size:
45,434 bases
Orientation:
Plus strand

Genomic View for TMCC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMCC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMCC2 Gene

Proteins for TMCC2 Gene

  • Protein details for TMCC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75069-TMCC2_HUMAN
    Recommended name:
    Transmembrane and coiled-coil domains protein 2
    Protein Accession:
    O75069
    Secondary Accessions:
    • A2RRH3
    • B7Z1P7
    • Q6ZN09

    Protein attributes for TMCC2 Gene

    Size:
    709 amino acids
    Molecular mass:
    77449 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA32326.3; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TMCC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMCC2 Gene

Proteomics data for TMCC2 Gene at MOPED

Post-translational modifications for TMCC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMCC2 Gene

Domains for TMCC2 Gene

Gene Families for TMCC2 Gene

HGNC:
  • TMCC :Transmembrane and coiled-coil domain containing

Protein Domains for TMCC2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O75069

UniProtKB/Swiss-Prot:

TMCC2_HUMAN :
  • O75069
Family:
  • Belongs to the TEX28 family.
genes like me logo Genes that share domains with TMCC2: view

Function for TMCC2 Gene

Gene Ontology (GO) - Molecular Function for TMCC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21593558
genes like me logo Genes that share ontologies with TMCC2: view

miRNA for TMCC2 Gene

miRTarBase miRNAs that target TMCC2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMCC2 Gene

Localization for TMCC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMCC2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMCC2 Gene COMPARTMENTS Subcellular localization image for TMCC2 gene
Compartment Confidence
nucleus 3
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TMCC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMCC2: view

Pathways for TMCC2 Gene

SuperPathways for TMCC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMCC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016192 vesicle-mediated transport --
genes like me logo Genes that share ontologies with TMCC2: view

No data available for Pathways by source for TMCC2 Gene

Transcripts for TMCC2 Gene

Unigene Clusters for TMCC2 Gene

Transmembrane and coiled-coil domain family 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMCC2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b
SP1: - - - - - - -
SP2: - - - -
SP3: - -
SP4: -
SP5: - - -
SP6:
SP7:

Relevant External Links for TMCC2 Gene

GeneLoc Exon Structure for
TMCC2
ECgene alternative splicing isoforms for
TMCC2

Expression for TMCC2 Gene

mRNA expression in normal human tissues for TMCC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMCC2 Gene

This gene is overexpressed in Whole Blood (4.8) and Brain - Spinal cord (cervical c-1) (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMCC2 Gene

SOURCE GeneReport for Unigene cluster for TMCC2 Gene Hs.6360

genes like me logo Genes that share expressions with TMCC2: view

No data available for mRNA Expression by UniProt/SwissProt for TMCC2 Gene

Orthologs for TMCC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMCC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMCC2 35
  • 99.15 (n)
  • 99.44 (a)
TMCC2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMCC2 35
  • 88.71 (n)
  • 89.71 (a)
TMCC2 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMCC2 35
  • 92.3 (n)
  • 96.88 (a)
TMCC2 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmcc2 35
  • 88.54 (n)
  • 94.18 (a)
Tmcc2 16
Tmcc2 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMCC2 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMCC2 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmcc2 35
  • 88.49 (n)
  • 93.89 (a)
chicken
(Gallus gallus)
Aves TMCC2 35
  • 80.31 (n)
  • 83.92 (a)
TMCC2 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMCC2 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmcc2 35
  • 68.25 (n)
  • 75.22 (a)
zebrafish
(Danio rerio)
Actinopterygii tmcc2 35
  • 77.95 (n)
  • 77.65 (a)
tmcc2 36
  • 77 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG1021 36
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C15H9.4 36
  • 23 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5750 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5281 36
  • 50 (a)
OneToMany
Species with no ortholog for TMCC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMCC2 Gene

ENSEMBL:
Gene Tree for TMCC2 (if available)
TreeFam:
Gene Tree for TMCC2 (if available)

Paralogs for TMCC2 Gene

Paralogs for TMCC2 Gene

Selected SIMAP similar genes for TMCC2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TMCC2: view

Variants for TMCC2 Gene

Sequence variations from dbSNP and Humsavar for TMCC2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs17728 -- 205,272,531(+) GGTTT(C/T)CTCTG utr-variant-3-prime
rs748011 -- 205,247,489(-) GCCAC(A/G)CCCAT intron-variant
rs748012 -- 205,247,445(-) TGCAA(C/T)TGAAG intron-variant
rs896322 -- 205,240,617(-) GAACA(C/T)CTATC intron-variant, upstream-variant-2KB
rs983337 -- 205,227,360(-) ACACA(A/G)TAACG upstream-variant-2KB

Relevant External Links for TMCC2 Gene

HapMap Linkage Disequilibrium report
TMCC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMCC2 Gene

Disorders for TMCC2 Gene

Relevant External Links for TMCC2

Genetic Association Database (GAD)
TMCC2
genes like me logo Genes that share disorders with TMCC2: view

No data available for UniProtKB/Swiss-Prot for TMCC2 Gene

Publications for TMCC2 Gene

  1. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PMID: 9455484) Seki N. … Ohara O. (DNA Res. 1997) 2 3 4
  2. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. (PMID: 19820697) Soranzo N. … Gieger C. (Nat. Genet. 2009) 3 48
  5. New gene functions in megakaryopoiesis and platelet formation. (PMID: 22139419) Gieger C. … Soranzo N. (Nature 2011) 3 48

Products for TMCC2 Gene

Sources for TMCC2 Gene

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