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Aliases for TMCC2 Gene

Aliases for TMCC2 Gene

  • Transmembrane And Coiled-Coil Domain Family 2 2 3 5
  • Cerebral Protein 11 3 4
  • Transmembrane And Coiled-Coil Domains Protein 2 3
  • Transmembrane And Coiled-Coil Domains 2 2
  • KIAA0481 4
  • HUCEP11 3

External Ids for TMCC2 Gene

Previous GeneCards Identifiers for TMCC2 Gene

  • GC01P201929
  • GC01P203463
  • GC01P176362

Summaries for TMCC2 Gene

GeneCards Summary for TMCC2 Gene

TMCC2 (Transmembrane And Coiled-Coil Domain Family 2) is a Protein Coding gene. An important paralog of this gene is TMCC1.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMCC2 Gene

Genomics for TMCC2 Gene

Regulatory Elements for TMCC2 Gene

Enhancers for TMCC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G205246 1.7 FANTOM5 Ensembl ENCODE dbSUPER 45.9 +21.1 21078 5.1 HDGF HDAC1 ATF1 PTBP1 ARNT TCF12 ZNF121 GLIS2 GATA2 CREM TMCC2 DSTYK CNTN2 CDK18 NUAK2 TMEM81 LOC101929459 NFASC MFSD4A PIR41674
GH01G205255 1.5 Ensembl ENCODE dbSUPER 38.4 +28.4 28388 0.6 HDGF PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A ZNF2 ZNF766 ZNF143 TMCC2 DSTYK NUAK2 CNTN2 PIR41674 LOC101929459
GH01G205293 2 FANTOM5 Ensembl ENCODE dbSUPER 23 +71.4 71371 12.4 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 TMCC2 NUAK2 DSTYK CDK18 LOC101929459 MFSD4A CNTN2 TMEM81 KLHDC8A ELK4
GH01G205283 2 FANTOM5 Ensembl ENCODE dbSUPER 22.7 +58.5 58505 5.6 HDGF PKNOX1 MLX CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 TMCC2 NUAK2 DSTYK LOC101929459 RBBP5 RAB29 PIR41674
GH01G205258 1.9 FANTOM5 Ensembl ENCODE dbSUPER 22.1 +31.4 31444 2.5 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF2 ZBTB7B ZNF766 ZNF143 FOS TMCC2 DSTYK ELK4 MDM4 GYG2P2 LOC101929459 NUAK2 RBBP5 KLHDC8A CNTN2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMCC2 on UCSC Golden Path with GeneCards custom track

Promoters for TMCC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000018739 590 2201 HDGF PKNOX1 ARNT FEZF1 ZNF2 ZBTB7B ZNF143 ZNF548 FOS SP3

Genomic Location for TMCC2 Gene

Chromosome:
1
Start:
205,227,910 bp from pter
End:
205,273,343 bp from pter
Size:
45,434 bases
Orientation:
Plus strand

Genomic View for TMCC2 Gene

Genes around TMCC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMCC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMCC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMCC2 Gene

Proteins for TMCC2 Gene

  • Protein details for TMCC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75069-TMCC2_HUMAN
    Recommended name:
    Transmembrane and coiled-coil domains protein 2
    Protein Accession:
    O75069
    Secondary Accessions:
    • A2RRH3
    • B7Z1P7
    • Q6ZN09

    Protein attributes for TMCC2 Gene

    Size:
    709 amino acids
    Molecular mass:
    77449 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA32326.3; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TMCC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMCC2 Gene

Post-translational modifications for TMCC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMCC2 Gene

Domains & Families for TMCC2 Gene

Gene Families for TMCC2 Gene

Protein Domains for TMCC2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O75069

UniProtKB/Swiss-Prot:

TMCC2_HUMAN :
  • Belongs to the TEX28 family.
Family:
  • Belongs to the TEX28 family.
genes like me logo Genes that share domains with TMCC2: view

Function for TMCC2 Gene

Gene Ontology (GO) - Molecular Function for TMCC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21593558
genes like me logo Genes that share ontologies with TMCC2: view
genes like me logo Genes that share phenotypes with TMCC2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMCC2 Gene

Localization for TMCC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMCC2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMCC2 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
nucleus 3

Gene Ontology (GO) - Cellular Components for TMCC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 21593558
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMCC2: view

Pathways & Interactions for TMCC2 Gene

SuperPathways for TMCC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMCC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042982 amyloid precursor protein metabolic process IDA 21593558
genes like me logo Genes that share ontologies with TMCC2: view

No data available for Pathways by source and SIGNOR curated interactions for TMCC2 Gene

Drugs & Compounds for TMCC2 Gene

No Compound Related Data Available

Transcripts for TMCC2 Gene

Unigene Clusters for TMCC2 Gene

Transmembrane and coiled-coil domain family 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMCC2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b
SP1: - - - - - - -
SP2: - - - -
SP3: - -
SP4: -
SP5: - - -
SP6:
SP7:

Relevant External Links for TMCC2 Gene

GeneLoc Exon Structure for
TMCC2
ECgene alternative splicing isoforms for
TMCC2

Expression for TMCC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMCC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMCC2 Gene

This gene is overexpressed in Whole Blood (x4.8) and Brain - Spinal cord (cervical c-1) (x4.4).

Protein differential expression in normal tissues from HIPED for TMCC2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (37.1) and Plasma (11.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMCC2 Gene



Protein tissue co-expression partners for TMCC2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMCC2 Gene:

TMCC2

SOURCE GeneReport for Unigene cluster for TMCC2 Gene:

Hs.6360

Evidence on tissue expression from TISSUES for TMCC2 Gene

  • Nervous system(4.9)
  • Blood(2)
genes like me logo Genes that share expression patterns with TMCC2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMCC2 Gene

Orthologs for TMCC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMCC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMCC2 34 35
  • 99.15 (n)
dog
(Canis familiaris)
Mammalia TMCC2 34 35
  • 92.3 (n)
oppossum
(Monodelphis domestica)
Mammalia TMCC2 35
  • 90 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMCC2 34 35
  • 88.71 (n)
mouse
(Mus musculus)
Mammalia Tmcc2 34 16 35
  • 88.54 (n)
rat
(Rattus norvegicus)
Mammalia Tmcc2 34
  • 88.49 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMCC2 35
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMCC2 34 35
  • 80.31 (n)
lizard
(Anolis carolinensis)
Reptilia TMCC2 35
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmcc2 34
  • 68.25 (n)
zebrafish
(Danio rerio)
Actinopterygii tmcc2 34 35
  • 77.95 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG1021 35
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C15H9.4 35
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5281 35
  • 50 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5750 34
Species where no ortholog for TMCC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMCC2 Gene

ENSEMBL:
Gene Tree for TMCC2 (if available)
TreeFam:
Gene Tree for TMCC2 (if available)

Paralogs for TMCC2 Gene

Paralogs for TMCC2 Gene

(4) SIMAP similar genes for TMCC2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TMCC2: view

Variants for TMCC2 Gene

Sequence variations from dbSNP and Humsavar for TMCC2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000010210 -- 205,273,346(+) CCATC(C/T)TGTCT downstream-variant-500B
rs1000093790 -- 205,231,540(+) GAAAC(A/T)CCTGC intron-variant
rs1000098012 -- 205,231,941(+) GCAAA(-/AATAAT)AATAA intron-variant
rs1000282860 -- 205,262,402(+) GGAGT(A/G)TCTCT intron-variant
rs1000358808 -- 205,255,270(+) GGTAT(C/T)TTGGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMCC2 Gene

Variant ID Type Subtype PubMed ID
nsv1126226 CNV deletion 24896259
nsv477442 CNV novel sequence insertion 20440878

Variation tolerance for TMCC2 Gene

Residual Variation Intolerance Score: 16.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.14; 61.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMCC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMCC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMCC2 Gene

Disorders for TMCC2 Gene

Relevant External Links for TMCC2

Genetic Association Database (GAD)
TMCC2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMCC2

No disorders were found for TMCC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMCC2 Gene

Publications for TMCC2 Gene

  1. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PMID: 9455484) Seki N. … Ohara O. (DNA Res. 1997) 2 3 4 64
  2. New gene functions in megakaryopoiesis and platelet formation. (PMID: 22139419) Gieger C. … Soranzo N. (Nature 2011) 3 46 64
  3. A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. (PMID: 19820697) Soranzo N. … Gieger C. (Nat. Genet. 2009) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4 64

Products for TMCC2 Gene

Sources for TMCC2 Gene

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