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Aliases for TMCC1 Gene

Aliases for TMCC1 Gene

  • Transmembrane And Coiled-Coil Domain Family 1 2 3
  • Transmembrane And Coiled-Coil Domains 1 2
  • KIAA0779 4

External Ids for TMCC1 Gene

Summaries for TMCC1 Gene

GeneCards Summary for TMCC1 Gene

TMCC1 (Transmembrane And Coiled-Coil Domain Family 1) is a Protein Coding gene. An important paralog of this gene is TMCC2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMCC1 Gene

Genomics for TMCC1 Gene

Genomic Location for TMCC1 Gene

Start:
129,647,792 bp from pter
End:
129,893,596 bp from pter
Size:
245,805 bases
Orientation:
Minus strand

Genomic View for TMCC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMCC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMCC1 Gene

Proteins for TMCC1 Gene

  • Protein details for TMCC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94876-TMCC1_HUMAN
    Recommended name:
    Transmembrane and coiled-coil domains protein 1
    Protein Accession:
    O94876
    Secondary Accessions:
    • A8K5Y3
    • B4DE04
    • Q68E06
    • Q8IXM8

    Protein attributes for TMCC1 Gene

    Size:
    653 amino acids
    Molecular mass:
    72083 Da
    Quaternary structure:
    • May form homo- or heterodimers with other TMCC proteins via the coiled-coil domains. Interacts with ribosomal proteins RPL4 and RPS6.

    Alternative splice isoforms for TMCC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMCC1 Gene

Proteomics data for TMCC1 Gene at MOPED

Post-translational modifications for TMCC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMCC1 Gene

No data available for DME Specific Peptides for TMCC1 Gene

Domains for TMCC1 Gene

Gene Families for TMCC1 Gene

HGNC:
  • TMCC :Transmembrane and coiled-coil domain containing

Protein Domains for TMCC1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

TMCC1_HUMAN
Family:
  • Belongs to the TEX28 family.:
    • O94876
genes like me logo Genes that share domains with TMCC1: view

Function for TMCC1 Gene

Phenotypes for TMCC1 Gene

GenomeRNAi human phenotypes for TMCC1:
genes like me logo Genes that share phenotypes with TMCC1: view

miRNA for TMCC1 Gene

miRTarBase miRNAs that target TMCC1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMCC1 Gene

Localization for TMCC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMCC1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMCC1 Gene COMPARTMENTS Subcellular localization image for TMCC1 gene
Compartment Confidence
plasma membrane 3
nucleus 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TMCC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMCC1: view

Pathways for TMCC1 Gene

SuperPathways for TMCC1 Gene

No Data Available

Interacting Proteins for TMCC1 Gene

Gene Ontology (GO) - Biological Process for TMCC1 Gene

None

No data available for Pathways by source for TMCC1 Gene

Transcripts for TMCC1 Gene

Unigene Clusters for TMCC1 Gene

Transmembrane and coiled-coil domain family 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMCC1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13
SP1: -
SP2: - - - - - - -
SP3: -
SP4: - - - - -
SP5: - -
SP6: - - - - - - - -
SP7: - - - - - - - - - -
SP8:
SP9: - - - - - - - - - - -
SP10: - - - -
SP11: - - - - - -

Relevant External Links for TMCC1 Gene

GeneLoc Exon Structure for
TMCC1
ECgene alternative splicing isoforms for
TMCC1

Expression for TMCC1 Gene

mRNA expression in normal human tissues for TMCC1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMCC1 Gene

SOURCE GeneReport for Unigene cluster for TMCC1 Gene Hs.477547

genes like me logo Genes that share expressions with TMCC1: view

Orthologs for TMCC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMCC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMCC1 36
  • 99.69 (n)
  • 100 (a)
TMCC1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMCC1 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMCC1 36
  • 95.13 (n)
  • 98.62 (a)
TMCC1 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmcc1 36
  • 90.86 (n)
  • 95.99 (a)
Tmcc1 16
Tmcc1 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMCC1 37
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMCC1 37
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmcc1 36
  • 90.65 (n)
  • 95.22 (a)
chicken
(Gallus gallus)
Aves TMCC1 36
  • 81.74 (n)
  • 90.43 (a)
TMCC1 37
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMCC1 37
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25587 36
tropical clawed frog
(Silurana tropicalis)
Amphibia tmcc1 36
  • 67.63 (n)
  • 70.04 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1926 36
zebrafish
(Danio rerio)
Actinopterygii TMCC1 (2 of 2) 37
  • 62 (a)
OneToMany
tmcc1b 36
  • 69.78 (n)
  • 73.06 (a)
tmcc1b 37
  • 69 (a)
OneToMany
wufd44g06 36
fruit fly
(Drosophila melanogaster)
Insecta CG1021 37
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C15H9.4 36
  • 42.94 (n)
  • 28.83 (a)
C15H9.4 37
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5281 37
  • 51 (a)
OneToMany
Species with no ortholog for TMCC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMCC1 Gene

ENSEMBL:
Gene Tree for TMCC1 (if available)
TreeFam:
Gene Tree for TMCC1 (if available)

Paralogs for TMCC1 Gene

Paralogs for TMCC1 Gene

Selected SIMAP similar genes for TMCC1 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for TMCC1 Gene

genes like me logo Genes that share paralogs with TMCC1: view

Variants for TMCC1 Gene

Sequence variations from dbSNP and Humsavar for TMCC1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs784687 -- 129,837,809(+) agaga(G/T)aaatg intron-variant
rs784688 -- 129,827,354(+) ATGTA(C/T)TACAA intron-variant
rs784689 - 129,827,886(+) AGAGC(C/T)GGTAG reference, missense, intron-variant
rs784690 -- 129,828,959(+) TCAGT(A/G)TAATC intron-variant
rs784693 -- 129,876,697(-) gatta(C/T)aggcg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMCC1 Gene

Variant ID Type Subtype PubMed ID
nsv508953 CNV Insertion 20534489
nsv877482 CNV Gain 21882294
nsv516538 CNV Gain 19592680
nsv877483 CNV Gain 21882294
esv2543950 CNV Deletion 19546169
esv2725904 CNV Deletion 23290073
esv2075495 CNV Deletion 18987734
nsv237038 CNV Loss 16902084
esv1008617 CNV Deletion 20482838
esv2725905 CNV Deletion 23290073
esv1519846 CNV Deletion 17803354
nsv238037 CNV Loss 16902084

Relevant External Links for TMCC1 Gene

HapMap Linkage Disequilibrium report
TMCC1

Disorders for TMCC1 Gene

Relevant External Links for TMCC1

Genetic Association Database (GAD)
TMCC1
Human Genome Epidemiology (HuGE) Navigator
TMCC1
genes like me logo Genes that share disorders with TMCC1: view

No data available for UniProtKB/Swiss-Prot for TMCC1 Gene

Publications for TMCC1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  4. Transmembrane and coiled-coil domain family 1 is a novel protein of the endoplasmic reticulum. (PMID: 24454821) Zhang C. … Qi R.Z. (PLoS ONE 2014) 3 4
  5. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 3

Products for TMCC1 Gene

Sources for TMCC1 Gene

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