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Aliases for TMCC1 Gene

Aliases for TMCC1 Gene

  • Transmembrane And Coiled-Coil Domain Family 1 2 3 5
  • Transmembrane And Coiled-Coil Domains 1 2
  • KIAA0779 4

External Ids for TMCC1 Gene

Previous GeneCards Identifiers for TMCC1 Gene

  • GC03M130851
  • GC03M129366
  • GC03M126749

Summaries for TMCC1 Gene

GeneCards Summary for TMCC1 Gene

TMCC1 (Transmembrane And Coiled-Coil Domain Family 1) is a Protein Coding gene. An important paralog of this gene is TMCC2.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMCC1 Gene

Genomics for TMCC1 Gene

Regulatory Elements for TMCC1 Gene

Enhancers for TMCC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G129917 0.7 FANTOM5 27.6 -23.8 -23785 0.3 CBX3 CEBPB ZEB2 CBX1 RAD51 CBX5 ZNF143 KDM1A TRIM24 SETDB1 TMCC1 RNY3P13 MBD4 ENSG00000203644 TMCC1-AS1 ENSG00000250643
GH03G129824 0.7 FANTOM5 24.8 +68.8 68791 0.2 CTCF PKNOX1 SAP130 ARID4B RAD21 TBX3 MIER3 ZNF24 CUX1 SP7 TMCC1 MBD4 H1FOO ENSG00000283509 ENSG00000203644
GH03G129653 1.5 Ensembl ENCODE dbSUPER 10.6 +237.2 237222 5.1 ATF1 MLX ARNT ARID4B DMAP1 YY1 GATA2 CBX5 FOS SP5 RNY3P13 PLXND1 TMCC1 RHO ENSG00000203644 TMCC1-AS1 PIR61156 GC03P129807
GH03G129910 0.9 FANTOM5 Ensembl ENCODE 14.8 -17.7 -17718 1.4 NR2F2 TMCC1 MBD4 TMCC1-AS1 ENSG00000250643
GH03G129828 1 Ensembl ENCODE 11 +63.7 63732 1.9 CTCF PKNOX1 SAP130 DNMT3B RAD21 YY1 ZNF143 SMC3 FOS MIXL1 TMCC1 RHO ENSG00000283509 ENSG00000203644
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMCC1 on UCSC Golden Path with GeneCards custom track

Promoters for TMCC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000158294 97 2201 FOXA2 ARID4B SIN3A DMAP1 ZNF48 YY1 TCF12 ZNF766 ELK1 ZNF143

Genomic Location for TMCC1 Gene

Chromosome:
3
Start:
129,647,792 bp from pter
End:
129,893,597 bp from pter
Size:
245,806 bases
Orientation:
Minus strand

Genomic View for TMCC1 Gene

Genes around TMCC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMCC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMCC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMCC1 Gene

Proteins for TMCC1 Gene

  • Protein details for TMCC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94876-TMCC1_HUMAN
    Recommended name:
    Transmembrane and coiled-coil domains protein 1
    Protein Accession:
    O94876
    Secondary Accessions:
    • A8K5Y3
    • B4DE04
    • Q68E06
    • Q8IXM8

    Protein attributes for TMCC1 Gene

    Size:
    653 amino acids
    Molecular mass:
    72083 Da
    Quaternary structure:
    • May form homo- or heterodimers with other TMCC proteins via the coiled-coil domains. Interacts with ribosomal proteins RPL4 and RPS6.

    Alternative splice isoforms for TMCC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMCC1 Gene

Post-translational modifications for TMCC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMCC1 Gene

Domains & Families for TMCC1 Gene

Gene Families for TMCC1 Gene

Protein Domains for TMCC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMCC1 Gene

Graphical View of Domain Structure for InterPro Entry

O94876

UniProtKB/Swiss-Prot:

TMCC1_HUMAN :
  • Belongs to the TEX28 family.
Family:
  • Belongs to the TEX28 family.
genes like me logo Genes that share domains with TMCC1: view

Function for TMCC1 Gene

genes like me logo Genes that share phenotypes with TMCC1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMCC1 Gene

Localization for TMCC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMCC1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMCC1 gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 3
nucleus 2

Gene Ontology (GO) - Cellular Components for TMCC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMCC1: view

Pathways & Interactions for TMCC1 Gene

SuperPathways for TMCC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMCC1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMCC1 Gene

Transcripts for TMCC1 Gene

Unigene Clusters for TMCC1 Gene

Transmembrane and coiled-coil domain family 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMCC1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13
SP1: -
SP2: - - - - - - -
SP3: -
SP4: - - - - -
SP5: - -
SP6: - - - - - - - -
SP7: - - - - - - - - - -
SP8:
SP9: - - - - - - - - - - -
SP10: - - - -
SP11: - - - - - -

Relevant External Links for TMCC1 Gene

GeneLoc Exon Structure for
TMCC1
ECgene alternative splicing isoforms for
TMCC1

Expression for TMCC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMCC1 Gene

Protein differential expression in normal tissues from HIPED for TMCC1 Gene

This gene is overexpressed in Adrenal (26.5), Fetal Brain (10.7), Testis (9.8), Retina (9.0), and Lung (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMCC1 Gene



Protein tissue co-expression partners for TMCC1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMCC1 Gene:

TMCC1

SOURCE GeneReport for Unigene cluster for TMCC1 Gene:

Hs.477547

Evidence on tissue expression from TISSUES for TMCC1 Gene

  • Nervous system(4.6)
  • Liver(4.3)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with TMCC1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMCC1 Gene

Orthologs for TMCC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMCC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMCC1 34 35
  • 99.69 (n)
cow
(Bos Taurus)
Mammalia TMCC1 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMCC1 34 35
  • 95.13 (n)
oppossum
(Monodelphis domestica)
Mammalia TMCC1 35
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmcc1 34 16 35
  • 90.86 (n)
rat
(Rattus norvegicus)
Mammalia Tmcc1 34
  • 90.65 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMCC1 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMCC1 34 35
  • 81.74 (n)
lizard
(Anolis carolinensis)
Reptilia TMCC1 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmcc1 34
  • 67.63 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25587 34
zebrafish
(Danio rerio)
Actinopterygii tmcc1b 34 35
  • 69.78 (n)
TMCC1 (2 of 2) 35
  • 62 (a)
OneToMany
wufd44g06 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1926 34
fruit fly
(Drosophila melanogaster)
Insecta CG1021 35
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C15H9.4 34 35
  • 42.94 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5281 35
  • 51 (a)
OneToMany
Species where no ortholog for TMCC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMCC1 Gene

ENSEMBL:
Gene Tree for TMCC1 (if available)
TreeFam:
Gene Tree for TMCC1 (if available)

Paralogs for TMCC1 Gene

Paralogs for TMCC1 Gene

(4) SIMAP similar genes for TMCC1 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for TMCC1 Gene

genes like me logo Genes that share paralogs with TMCC1: view

Variants for TMCC1 Gene

Sequence variations from dbSNP and Humsavar for TMCC1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000003865 -- 129,754,511(+) GGATA(C/T)GGTCC intron-variant
rs1000010079 -- 129,708,526(+) GCTGA(A/G)TCACA intron-variant
rs1000018136 -- 129,795,093(+) GGTGC(A/T)GAGAG intron-variant, upstream-variant-2KB
rs1000022178 -- 129,707,271(+) TATCA(A/C)CTCAA intron-variant
rs1000034064 -- 129,692,188(+) ACTTA(A/C/T)ACAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMCC1 Gene

Variant ID Type Subtype PubMed ID
esv1008617 CNV deletion 20482838
esv1519846 CNV deletion 17803354
esv2075495 CNV deletion 18987734
esv2543950 CNV deletion 19546169
esv2725904 CNV deletion 23290073
esv2725905 CNV deletion 23290073
esv3597745 CNV loss 21293372
esv3597746 CNV loss 21293372
esv3597747 CNV gain 21293372
esv3597750 CNV loss 21293372
nsv1074623 CNV deletion 25765185
nsv237038 CNV deletion 16902084
nsv238037 CNV deletion 16902084
nsv475803 CNV novel sequence insertion 20440878
nsv508953 CNV insertion 20534489
nsv516538 CNV gain 19592680
nsv591676 CNV loss 21841781
nsv956830 CNV deletion 24416366

Variation tolerance for TMCC1 Gene

Residual Variation Intolerance Score: 8.99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.02; 20.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMCC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMCC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMCC1 Gene

Disorders for TMCC1 Gene

Relevant External Links for TMCC1

Genetic Association Database (GAD)
TMCC1
Human Genome Epidemiology (HuGE) Navigator
TMCC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMCC1

No disorders were found for TMCC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMCC1 Gene

Publications for TMCC1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 64
  2. Transmembrane and coiled-coil domain family 1 is a novel protein of the endoplasmic reticulum. (PMID: 24454821) Zhang C. … Qi R.Z. (PLoS ONE 2014) 3 4 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 3 64

Products for TMCC1 Gene

Sources for TMCC1 Gene

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