Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TMCC1 Gene

protein-coding   GIFtS: 51
GCID: GC03M129366

Transmembrane And Coiled-Coil Domain Family 1

(Previous name: transmembrane and coiled-coil domains 1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Transmembrane And Coiled-Coil Domain Family 11 2
Transmembrane And Coiled-Coil Domains 11
Transmembrane And Coiled-Coil Domains Protein 12
KIAA07793

External Ids:    HGNC: 291161   Entrez Gene: 230232   Ensembl: ENSG000001727657   UniProtKB: O948763   

Export aliases for TMCC1 gene to outside databases

Previous GC identifers: GC03M130851 GC03M126749


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for TMCC1 Gene:
TMCC1 (transmembrane and coiled-coil domain family 1) is a protein-coding gene. Diseases associated with TMCC1 include facial paralysis, and cervical adenocarcinoma. An important paralog of this gene is TEX28P1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000003.12  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMCC1 gene promoter:
         POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   E47   C/EBPalpha   deltaCREB   Zic1   FOXJ2 (long isoform)   FOXJ2   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TMCC1 promoter sequence
   Search Chromatin IP Primers for TMCC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMCC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q22.1   Ensembl cytogenetic band:  3q22.1   HGNC cytogenetic band: 3q21.3

TMCC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMCC1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M129366:  view genomic region     (about GC identifiers)

Start:
129,366,635 bp from pter      End:
129,612,419 bp from pter
Size:
245,785 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TMCC1_HUMAN, O94876 (See protein sequence)
Recommended Name: Transmembrane and coiled-coil domains protein 1  
Size: 653 amino acids; 72083 Da
Secondary accessions: Q68E06 Q8IXM8

Explore the universe of human proteins at neXtProt for TMCC1: NX_O94876

Explore proteomics data for TMCC1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TMCC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001017395.2  NP_001121696.1  

    ENSEMBL proteins: 
     ENSP00000404711   ENSP00000376930   ENSP00000426180   ENSP00000422544   ENSP00000427352  
     ENSP00000389892   ENSP00000327349  

    TMCC1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TMCC1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TMCC1
    GenScript Custom Purified and Recombinant Proteins Services for TMCC1
    Novus Biologicals TMCC1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TMCC1

    TMCC1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TMCC1
    Novus Biologicals TMCC1 Antibodies
    Abcam antibodies for TMCC1
    Cloud-Clone Corp. Antibodies for TMCC1
    ThermoFisher Antibodies for TMCC1
    LSBio Antibodies in human, mouse, rat for TMCC1

    TMCC1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TMCC1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TMCC1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TMCC1
    Cloud-Clone Corp. CLIAs for TMCC1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    TMCC: Transmembrane and coiled-coil domain containing

    1 InterPro protein domain:
     IPR019394 Predicted_TM_coiled-coil_2

    Graphical View of Domain Structure for InterPro Entry O94876

    ProtoNet protein and cluster: O94876

    UniProtKB/Swiss-Prot: TMCC1_HUMAN, O94876
    Similarity: Belongs to the TEX28 family


    TMCC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Phenotypes:
         1 GenomeRNAi human phenotype for TMCC1:
     Proliferating cells 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMCC1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TMCC1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMCC1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMCC1

    miRNA
    Products:
        
    miRTarBase miRNAs that target TMCC1:
    hsa-mir-1 (MIRT023737), hsa-mir-16-5p (MIRT031658), hsa-mir-103a-3p (MIRT027104)

    Block miRNA regulation of human, mouse, rat TMCC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TMCC1 (see all 125):
    hsa-miR-579 hsa-miR-520e hsa-miR-607 hsa-miR-640 hsa-miR-15a hsa-miR-517a hsa-miR-106a hsa-miR-128
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TMCC1
    Predesigned siRNA for gene silencing in human, mouse, rat TMCC1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TMCC1

    Clone
    Products:
         
    OriGene clones in human, mouse for TMCC1 (see all 17)
    OriGene ORF clones in mouse, rat for TMCC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TMCC1 (NM_001017395)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMCC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMCC1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TMCC1
    Browse ESI BIO Cell Lines and PureStem Progenitors for TMCC1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMCC1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TMCC1_HUMAN, O94876: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    nucleus2
    endoplasmic reticulum1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    TMCC1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMCC1
    Interactions:

        Search GeneGlobe Interaction Network for TMCC1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for TMCC1 (O948763 ENSP000003273494) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GOSR2O146533I2D: score=5 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMCC1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TMCC1 gene (3 alternative transcripts): 
    NM_015008.4  NM_001017395.3  NM_001128224.2  

    Unigene Cluster for TMCC1:

    Transmembrane and coiled-coil domain family 1
    Hs.477547  [show with all ESTs]
    Unigene Representative Sequence: NM_001017395
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000432054(uc003emy.4 uc011blc.2) ENST00000393238(uc021xdy.1)
    ENST00000510323 ENST00000505616 ENST00000505924 ENST00000513411 ENST00000512902
    ENST00000508869 ENST00000503256 ENST00000515024 ENST00000508729 ENST00000509440
    ENST00000510521 ENST00000426664(uc010htg.3) ENST00000329333
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TMCC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TMCC1 (see all 125):
    hsa-miR-579 hsa-miR-520e hsa-miR-607 hsa-miR-640 hsa-miR-15a hsa-miR-517a hsa-miR-106a hsa-miR-128
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TMCC1
    Predesigned siRNA for gene silencing in human, mouse, rat TMCC1
    Clone
    Products:
         
    OriGene clones in human, mouse for TMCC1 (see all 17)
    OriGene ORF clones in mouse, rat for TMCC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TMCC1 (NM_001017395)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMCC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMCC1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TMCC1
    OriGene qSTAR qPCR primer pairs in human, mouse for TMCC1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMCC1
      QuantiTect SYBR Green Assays in human, mouse, rat TMCC1
      QuantiFast Probe-based Assays in human, mouse, rat TMCC1

    Additional mRNA sequence: 

    AB018322.1 AK124671.1 AK291448.1 AK293408.1 BC012480.1 BC030619.2 BC034284.1 BC039859.1 
    BC047517.1 BX640712.1 CR749206.1 NR_033361.1 

    12 DOTS entries:

    DT.111960  DT.75152592  DT.106465  DT.120842303  DT.99994816  DT.439390  DT.40131938  DT.92056438 
    DT.95369836  DT.40112647  DT.92417879  DT.91854191 

    Selected AceView cDNA sequences (see all 190):

    AI570585 AA902972 AA937225 AA731142 AA057240 BX493634 AA961064 BI524041 
    BM670618 AI733924 AI916688 AI580157 AA886998 AI340066 CA867002 AI866967 
    BF882486 BM693877 AA234765 AL602908 BC034284 CF551938 AW959801 BG254657 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TMCC1 (see all 11)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13
    SP1:                                                                                                        -         
    SP2:              -     -     -     -     -     -           -                                                         
    SP3:              -                                                                                                   
    SP4:                    -     -     -     -     -                                                                     
    SP5:              -     -                                                                                             


    ECgene alternative splicing isoforms for TMCC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TMCC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCCTTTGAG
    TMCC1 Expression
    About this image

    TMCC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMCC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.477547
        Custom PCR Arrays for TMCC1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TMCC1
    OriGene qSTAR qPCR primer pairs in human, mouse for TMCC1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMCC1
    QuantiTect SYBR Green Assays in human, mouse, rat TMCC1
    QuantiFast Probe-based Assays in human, mouse, rat TMCC1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMCC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for TMCC1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmcc11 , 5 transmembrane and coiled coil domains 11, 5 90.86(n)1
    95.99(a)1
      6 (53.72 cM)5
    3304011  NM_177412.11  NP_803131.11 
     1160186185 
    chicken
    (Gallus gallus)
    Aves TMCC11 transmembrane and coiled-coil domain family 1 81.74(n)
    90.43(a)
      416125  XM_414456.4  XP_414456.2 
    lizard
    (Anolis carolinensis)
    Reptilia TMCC16
    transmembrane and coiled-coil domain family 1
    86(a)
    1 ↔ 1
    GL343273.1(89259-241661)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.255872 Xenopus laevis transcribed sequence with moderate similarity to protein spO94876 (H.sapiens) Y779_HUMAN Hypothetical protein KIAA0779 less 78.26(n)    BJ626097.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufd44g062 Transcribed sequence with moderate similarity to protein spO94876 (H.sapiens) Y779_HUMAN Hypothetical protein KIAA0779 less 75.52(n)    CF999938.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG10216
    --
    32(a)
    1 → many
    3R(2214884-2231613)
    worm
    (Caenorhabditis elegans)
    Secernentea C15H9.41 C15H9.4 42.94(n)
    28.83(a)
      182643  NM_076620.2  NP_509021.2 


    ENSEMBL Gene Tree for TMCC1 (if available)
    TreeFam Gene Tree for TMCC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TMCC1 gene
    TEX28P12  TEX28P22  TMCC32  TEX282  TMCC22  
    4 SIMAP similar genes for TMCC1 using alignment to 6 protein entries:     TMCC1_HUMAN (see all proteins):
    DKFZp686H13261    TMCC2    TMCC3    TEX28

    TMCC1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for TMCC1
    PGOHUM00000240672 PGOHUM00000249471


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TMCC1 (see all 4246)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs359329281,2
    C--126887955(+) ACACA-/G/GAA 
            
    GGAGT
    2 -- int11NA 2
    rs105769241,2
    C--126887956(+) cacaG-/AAGGAGTA 2 -- int11Minor allele frequency- AAG:0.00NA 2
    rs26259471,2
    C,H--129366171(-) CCCTGG/CGGGGG 3 -- int111Minor allele frequency- C:0.03NA WA CSA 255
    rs26259461,2
    C,F,A,H--129366185(-) TGTATA/GTTGCC 3 -- int125Minor allele frequency- N:0.00NS EA NA CSA WA 2564
    rs1408396281,2
    --129366228(+) TATTTG/TAAGGG 3 -- int10--------
    rs1891850391,2
    --129366261(+) ATGTAA/TCCCTT 3 -- int10--------
    rs1819470641,2
    --129366331(+) ATGGGA/GTAAGA 3 -- int10--------
    rs729772191,2
    C,F--129366516(+) TACTTT/CTATAA 3 -- int13Minor allele frequency- C:0.21NA WA 122
    rs1849902171,2
    --129366630(+) GACCAC/GCAGGT 3 -- int10--------
    rs1501335481,2
    --129366654(+) CTTTAC/TTTCAA 3 -- nc-transcript-variantut310--------

    HapMap Linkage Disequilibrium report for TMCC1 (129366635 - 129612419 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TMCC1 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2075495CNV Deletion18987734
    esv1519846CNV Deletion17803354
    esv2543950CNV Deletion19546169
    esv2725905CNV Deletion23290073
    esv2725904CNV Deletion23290073
    esv1008617CNV Deletion20482838
    nsv508953CNV Insertion20534489
    nsv238037CNV Loss16902084
    nsv237038CNV Loss16902084
    nsv516538CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TMCC1
    DNA2.0 Custom Variant and Variant Library Synthesis for TMCC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    5 diseases for TMCC1:    
    About MalaCards
    facial paralysis    cervical adenocarcinoma    choroiditis    cervicitis
    adenocarcinoma


    TMCC1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TMCC1
    Human Genome Epidemiology (HuGE) Navigator: TMCC1 (1 document)

    Export disorders for TMCC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TMCC1 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with TMCC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1998)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    6. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    7. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    8. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    9. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (Mol. Cell 2008)
    10. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 23023 HGNC: 29116 AceView: KIAA0779 Ensembl:ENSG00000172765 euGenes: HUgn23023
    ECgene: TMCC1 H-InvDB: TMCC1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA0779

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TMCC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TMCC1 gene:
    Search GeneIP for patents involving TMCC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TMCC1  
     OriGene qPCR primer pairs and template standards for TMCC1   OriGene Protein Over-expression Lysate for TMCC1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TMCC1  
     OriGene qSTAR qPCR primer pairs in human, mouse for TMCC1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TMCC1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TMCC1   OriGene Custom Protein Services for TMCC1  

     
     
     Block miRNA regulation of human, mouse, rat TMCC1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TMCC1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMCC1 Predesigned siRNA for gene silencing in human, mouse, rat TMCC1
     QuantiFast Probe-based Assays in human, mouse, rat TMCC1 QuantiTect SYBR Green Assays in human, mouse, rat TMCC1
     Custom PCR Arrays for TMCC1 Search Chromatin IP Primers for TMCC1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMCC1  Search GeneGlobe Interaction Network for TMCC1
     Regulatory tfbs in TMCC1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TMCC1 GenScript cDNA clones with any tag delivered in your preferred vector for TMCC1
     GenScript Custom Assay Services for TMCC1 GenScript Custom overexpressing Cell Line Services for TMCC1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TMCC1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TMCC1 antibodies
     TMCC1 lysates
     Antibodies for TMCC1
     See all of Abcam's Antibodies, Kits and Proteins for TMCC1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for TMCC1
     Antibodies for TMCC1
     ELISAs for TMCC1
     CLIAs for TMCC1



     Browse ESI BIO Cell Lines and PureStem Progenitors for TMCC1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMCC1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for TMCC1
     SwitchGear Promoter luciferase reporter plasmids for TMCC1
     ThermoFisher Antibodies for TMCC1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMCC1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMCC1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TMCC1
     LSBio Antibodies in human, mouse, rat for TMCC1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TMCC1 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4