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Aliases for TMCC1 Gene

Aliases for TMCC1 Gene

  • Transmembrane And Coiled-Coil Domain Family 1 2 3 5
  • Transmembrane And Coiled-Coil Domains 1 2
  • KIAA0779 4

External Ids for TMCC1 Gene

Previous GeneCards Identifiers for TMCC1 Gene

  • GC03M130851
  • GC03M129366
  • GC03M126749

Summaries for TMCC1 Gene

GeneCards Summary for TMCC1 Gene

TMCC1 (Transmembrane And Coiled-Coil Domain Family 1) is a Protein Coding gene. An important paralog of this gene is TMCC2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMCC1 Gene

Genomics for TMCC1 Gene

Regulatory Elements for TMCC1 Gene

Promoters for TMCC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMCC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMCC1 Gene

Chromosome:
3
Start:
129,647,792 bp from pter
End:
129,893,597 bp from pter
Size:
245,806 bases
Orientation:
Minus strand

Genomic View for TMCC1 Gene

Genes around TMCC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMCC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMCC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMCC1 Gene

Proteins for TMCC1 Gene

  • Protein details for TMCC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94876-TMCC1_HUMAN
    Recommended name:
    Transmembrane and coiled-coil domains protein 1
    Protein Accession:
    O94876
    Secondary Accessions:
    • A8K5Y3
    • B4DE04
    • Q68E06
    • Q8IXM8

    Protein attributes for TMCC1 Gene

    Size:
    653 amino acids
    Molecular mass:
    72083 Da
    Quaternary structure:
    • May form homo- or heterodimers with other TMCC proteins via the coiled-coil domains. Interacts with ribosomal proteins RPL4 and RPS6.

    Alternative splice isoforms for TMCC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMCC1 Gene

Proteomics data for TMCC1 Gene at MOPED

Post-translational modifications for TMCC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMCC1 Gene

No data available for DME Specific Peptides for TMCC1 Gene

Domains & Families for TMCC1 Gene

Gene Families for TMCC1 Gene

Protein Domains for TMCC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMCC1 Gene

Graphical View of Domain Structure for InterPro Entry

O94876

UniProtKB/Swiss-Prot:

TMCC1_HUMAN :
  • Belongs to the TEX28 family.
Family:
  • Belongs to the TEX28 family.
genes like me logo Genes that share domains with TMCC1: view

Function for TMCC1 Gene

genes like me logo Genes that share phenotypes with TMCC1: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMCC1 Gene

Localization for TMCC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMCC1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMCC1 Gene COMPARTMENTS Subcellular localization image for TMCC1 gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 3
nucleus 2

Gene Ontology (GO) - Cellular Components for TMCC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMCC1: view

Pathways & Interactions for TMCC1 Gene

SuperPathways for TMCC1 Gene

No Data Available

Interacting Proteins for TMCC1 Gene

Gene Ontology (GO) - Biological Process for TMCC1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMCC1 Gene

Drugs & Compounds for TMCC1 Gene

No Compound Related Data Available

Transcripts for TMCC1 Gene

Unigene Clusters for TMCC1 Gene

Transmembrane and coiled-coil domain family 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMCC1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13
SP1: -
SP2: - - - - - - -
SP3: -
SP4: - - - - -
SP5: - -
SP6: - - - - - - - -
SP7: - - - - - - - - - -
SP8:
SP9: - - - - - - - - - - -
SP10: - - - -
SP11: - - - - - -

Relevant External Links for TMCC1 Gene

GeneLoc Exon Structure for
TMCC1
ECgene alternative splicing isoforms for
TMCC1

Expression for TMCC1 Gene

mRNA expression in normal human tissues for TMCC1 Gene

Protein differential expression in normal tissues from HIPED for TMCC1 Gene

This gene is overexpressed in Adrenal (26.5), Fetal Brain (10.7), Testis (9.8), Retina (9.0), and Lung (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMCC1 Gene



SOURCE GeneReport for Unigene cluster for TMCC1 Gene Hs.477547

genes like me logo Genes that share expression patterns with TMCC1: view

Protein tissue co-expression partners for TMCC1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMCC1 Gene

Orthologs for TMCC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMCC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMCC1 36
  • 100 (a)
OneToOne
TMCC1 35
  • 99.69 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia TMCC1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMCC1 35
  • 95.13 (n)
  • 98.62 (a)
TMCC1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmcc1 36
  • 96 (a)
OneToOne
Tmcc1 35
  • 90.86 (n)
  • 95.99 (a)
Tmcc1 16
oppossum
(Monodelphis domestica)
Mammalia TMCC1 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMCC1 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmcc1 35
  • 90.65 (n)
  • 95.22 (a)
chicken
(Gallus gallus)
Aves TMCC1 35
  • 81.74 (n)
  • 90.43 (a)
TMCC1 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMCC1 36
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25587 35
tropical clawed frog
(Silurana tropicalis)
Amphibia tmcc1 35
  • 67.63 (n)
  • 70.04 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1926 35
zebrafish
(Danio rerio)
Actinopterygii tmcc1b 35
  • 69.78 (n)
  • 73.06 (a)
wufd44g06 35
TMCC1 (2 of 2) 36
  • 62 (a)
OneToMany
tmcc1b 36
  • 69 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG1021 36
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C15H9.4 36
  • 22 (a)
OneToMany
C15H9.4 35
  • 42.94 (n)
  • 28.83 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5281 36
  • 51 (a)
OneToMany
Species with no ortholog for TMCC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMCC1 Gene

ENSEMBL:
Gene Tree for TMCC1 (if available)
TreeFam:
Gene Tree for TMCC1 (if available)

Paralogs for TMCC1 Gene

Paralogs for TMCC1 Gene

(4) SIMAP similar genes for TMCC1 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for TMCC1 Gene

genes like me logo Genes that share paralogs with TMCC1: view

Variants for TMCC1 Gene

Sequence variations from dbSNP and Humsavar for TMCC1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs784689 - 129,827,886(+) AGAGC(C/T)GGTAG intron-variant, reference, missense
rs796755 -- 129,881,919(-) cacac(A/G)tcgct intron-variant, upstream-variant-2KB
rs784701 -- 129,846,676(+) GGAAA(C/T)CCAAG intron-variant
rs784702 -- 129,846,766(+) GCTCA(A/T)GCCCA intron-variant
rs784703 -- 129,849,631(+) ggtgg(C/T)ggcgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMCC1 Gene

Variant ID Type Subtype PubMed ID
nsv508953 CNV Insertion 20534489
nsv877482 CNV Gain 21882294
nsv516538 CNV Gain 19592680
nsv877483 CNV Gain 21882294
esv2543950 CNV Deletion 19546169
esv2725904 CNV Deletion 23290073
esv2075495 CNV Deletion 18987734
nsv237038 CNV Loss 16902084
esv1008617 CNV Deletion 20482838
esv2725905 CNV Deletion 23290073
esv1519846 CNV Deletion 17803354
nsv238037 CNV Loss 16902084

Variation tolerance for TMCC1 Gene

Residual Variation Intolerance Score: 8.99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.02; 20.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMCC1 Gene

HapMap Linkage Disequilibrium report
TMCC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMCC1 Gene

Disorders for TMCC1 Gene

Relevant External Links for TMCC1

Genetic Association Database (GAD)
TMCC1
Human Genome Epidemiology (HuGE) Navigator
TMCC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMCC1

No disorders were found for TMCC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMCC1 Gene

Publications for TMCC1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 67
  2. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 3
  3. Transmembrane and coiled-coil domain family 1 is a novel protein of the endoplasmic reticulum. (PMID: 24454821) Zhang C. … Qi R.Z. (PLoS ONE 2014) 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for TMCC1 Gene

Sources for TMCC1 Gene

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