TMC8 Gene
protein-coding GIFtS: 52
GCID: GC17P076126
|
|
transmembrane channel-like 8(Previous name: epidermodysplasia verruciformis 2 )
(Previous symbol: EVER2)
| |
Aliases
for TMC8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Channel-Like 81 2 | | Epidermodysplasia Verruciformis Protein 22 3 | | EVER21 2 3 5 | | EV22 5 | | EVIN21 2 3 | | Transmembrane Channel-Like Protein 82 | | Epidermodysplasia Verruciformis 21 2 | | |
Export aliases for TMC8 gene to outside databasesPrevious GC identifers: GC17P073639 GC17P071551 |
Summaries
for TMC8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TMC8:
Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility tohuman papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV iscaused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integralmembrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. Thisgene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs.(provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: TMC8_HUMAN, Q8IU68Function: Probable ion channel (By similarity)
Gene Wiki entry for TMC8
|
Genomic Views
for TMC8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMC8 gene promoter:
c-Ets-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMC8
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMC8 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q25.3 Ensembl cytogenetic band: 17q25.3 HGNC cytogenetic band: 17q25.3TMC8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P076126: view genomic region
(about GC identifiers)
Start:
|
76,126,851 bp from pter |
End:
|
76,139,049 bp from pter |
Size:
|
12,199 bases |
Orientation:
|
plus strand |
|
Proteins
for TMC8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TMC8_HUMAN, Q8IU68 (See
protein sequence)Recommended Name: Transmembrane channel-like protein 8 Size: 726 amino acids; 81641 Da
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Sequence caution: Sequence=BAC03459.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;Sequence=BC028076; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites;
Secondary accessions: Q2YDC0 Q8IWU7 Q8N358 Q8NF04Alternative splicing: 2 isoforms: Q8IU68-1 Q8IU68-2 Explore the universe of human proteins at neXtProt for TMC8: NX_Q8IU68
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IU68
TMC8 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689681.2
ENSEMBL proteins: ENSP00000467460 ENSP00000465049 ENSP00000325561 ENSP00000467482
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005789 | endoplasmic reticulum membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
TMC8 for ontologies About GeneDecksing
TMC8 Antibody Products:
Assay Products for TMC8: |
Protein
Domains /
Families
for TMC8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMC8 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8IU68ProtoNet protein and cluster: Q8IU68 1 Blocks protein family: IPB012496 TMC
UniProtKB/Swiss-Prot: TMC8_HUMAN, Q8IU68Similarity: Belongs to the TMC family |
Function
for TMC8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TMC8_HUMAN, Q8IU68Function: Probable ion channel (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMC8 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMC8
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TMC8 (NM_152468) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMC8 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMC8 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMC8 |
Animal Models:
5 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Tmc8):
TMC8 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TMC8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMC8
|
Drugs & Compounds
for TMC8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMC8
Search CenterWatch for drugs/clinical trials and news about TMC8
|
Transcripts
for TMC8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMC8 gene: NM_152468.4 Unigene Cluster for TMC8: Transmembrane channel-like 8 Hs.592102 [show with all ESTs]Unigene Representative Sequence: NM_1524689 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000590426 ENST00000590799 ENST00000318430(uc010dhh.1 uc002jup.2 uc002juq.2 uc010wtr.1 uc002jur.1)
ENST00000589691 ENST00000592399 ENST00000591983 ENST00000590184 ENST00000591003
ENST00000591144
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMC8 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMC8
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TMC8 (NM_152468) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMC8 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMC8 |
Additional cDNA sequence: AK090478.1 AK097987.1 AK128327.1 AK303499.1 AK310623.1 AL834508.1 AY057380.1 AY099358.1 AY099359.1 AY236500.1 BC110296.1 BC141865.1 8 DOTS entries: DT.410907 DT.95359051 DT.101973957 DT.91823948 DT.95286901 DT.95358433 DT.100747028 DT.121009541 24/100 AceView cDNA sequences (see all 100): AY057380 AA814453 C04782 BP368131 BQ052577 CR598574 AW151554 AW071081 AW189764 AW445050 AI801411 AW085753 AI473525 BU951034 BF902041 AW291257 BQ053854 AY236500 AK128327 BG341827 BQ003280 AW451758 BM920471 AA806299
GeneLoc Exon Structure
5/12 Alternative Splicing Database (ASD) splice patterns (SP) for TMC8 (see all 12) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | · | 9d | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c | · | 11d | ^ | 12a | · | 12b | ^ | 13 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | - | | | | | | - | | | | - | | | | | | | | | | | | - | | | | - | | - | | | | - | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | - | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | - | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | | |
| ExUns: | 14 | ^ | 15a | · | 15b |
|---|
|
| SP1: | | | | | | | |
| SP2: | | | | | | | |
| SP3: | | | | | | | |
| SP4: | | | | | | | |
| SP5: | | | | | | |
ECgene alternative splicing isoforms for TMC8
|
Expression
for TMC8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMC8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCCTCCAAG
About this image
See TMC8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMC8
SOURCE GeneReport for Unigene cluster: Hs.592102
UniProtKB/Swiss-Prot: TMC8_HUMAN, Q8IU68Tissue specificity: Expressed in placenta, prostate and testis
SABiosciences Custom PCR Arrays for TMC8
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMC8
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMC8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMC8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMC8 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMC8 |
Orthologs
for TMC8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TMC8 gene from 3/14 species (see all 14) About this table
ENSEMBL Gene Tree for TMC8 (if available)
TreeFam Gene Tree for TMC8 (if available) |
Paralogs
for TMC8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TMC8 gene
- TMC72 TMC32 TMC22 TMC52 TMC62 TMC12 TMC42
2 SIMAP similar genes for TMC8 using alignment to 3 protein entries: TMC8_HUMAN (see all proteins):TMC7 TMC4
TMC8 for paralogs About GeneDecksing
|
Genomic Variants
for TMC8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMC8 (76126851 - 76139049 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for TMC8
2 CNVs: 30027 49933
Human Gene Mutation Database (HGMD): TMC8
Locus Specific Mutation Databases (LSDB): TMC8
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMC8 |
|
Disorders
/ Diseases
for TMC8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TMC8 for disorders About GeneDecksing
OMIM gene information: 605829
OMIM disorders: 226400
UniProtKB/Swiss-Prot: TMC8_HUMAN, Q8IU68
Defects in TMC8 are a cause of epidermodysplasia verruciformis (EV) [MIM:226400]. It is a rare autosomalrecessive genodermatosis associated with a high risk of skin carcinoma that results from an abnormal susceptibility toinfection by specific human papillomaviruses. Infection leads to persistent wart-like or macular lesions
8  diseases for TMC8: About MalaCardsepidermodysplasia verruciformis squamous cell carcinoma pityriasis versicolor carcinoma
hearing loss skin carcinoma skin cancer prostatitis
3 diseases from the University of Copenhagen DISEASES database for TMC8:Epidermodysplasia verruciformis Pityriasis versicolor Skin cancer 2 Novoseek disease relationships for TMC8 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| epidermodysplasia verruciformis |
95.2 |
6 |
19706093 (2), 16045695 (1), 12906855 (1), 17368633 (1) |
| skin carcinoma |
77.9 |
1 |
12812529 (1) |
Human Genome Epidemiology (HuGE) Navigator: TMC8 (2 documents)
Export disorders for TMC8 gene to outside databases
|
Publications
for TMC8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMC8 gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with TMC8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Mutations in two adjacent novel genes are associated with epidermodysplasia verruciformis. (PubMed id 12426567)1, 2, 3, 9 Ramoz N.... Favre M. (2002)
- Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis. (PubMed id 12906855)1, 2, 9 Kurima K.... Griffith A.J. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Cutaneous human papillomavirus infection, the EVER2 gene and incidence of squamous cell carcinoma: a case-control study. (PubMed id 18224692)1, 9 Patel A.S....Nelson H.H. (2008)
- Autosomal dominant epidermodysplasia verruciformis la cking a known EVER1 or EVER2 mutation. (PubMed id 19706093)1, 9 McDermott D.F....Hwang S.T. (2009)
- Regulation of cellular zinc balance as a potential mechanism of EVER-mediated protection against pathogenesis by cutaneous oncogenic human papillomaviruses. (PubMed id 18158319)1, 9 Lazarczyk M....Favre M. (2008)
- TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins. (PubMed id 12812529)1, 9 Keresztes G.... Heller S. (2003)
- Lack of EVER2 protein in two epidermodysplasia verruci formis patients with skin cancer presenting previously unreported homozygous gen etic deletions in the EVER2 gene. (PubMed id 22158547)1 Landini M.M....Gariglio M. (2012)
- Contribution of TMC6 and TMC8 (EVER1 and EVER2) varian ts to cervical cancer susceptibility. (PubMed id 21387292)1 Castro F.A....Pawlita M. (2012)
- EVER proteins, key elements of the natural anti-human papillomavirus barrier, are regulated upon T-cell activation. (PubMed id 22761942)1 Lazarczyk M....Liblau R.S. (2012)
|
External Searches for TMC8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMC8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMC8 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMC8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for TMC8 gene:
Search GeneIP for patents involving TMC8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMC8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for TMC8 | | OriGene shRNA RFP for TMC8 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMC8 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMC8 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for TMC8 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMC8 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMC8 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TMC8 | | OriGene Custom Protein Services for TMC8 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMC8 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMC8 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMC8 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMC8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMC8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMC8 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for TMC8 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | TMC8 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMC8 |
|  |  |  | | | | ThermoFisher Antibodies for TMC8 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMC8 |
|
|
|
|
