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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMC8 Gene

protein-coding   GIFtS: 52
GCID: GC17P076126

Transmembrane Channel-Like 8

(Previous name: epidermodysplasia verruciformis 2)
(Previous symbol: EVER2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transmembrane Channel-Like 81 2     EVIN22 3
EVER21 2 3 5     EV22 5
Epidermodysplasia Verruciformis 21 2     Transmembrane Channel-Like Protein 82
Epidermodysplasia Verruciformis Protein 22 3     

External Ids:    HGNC: 204741   Entrez Gene: 1471382   Ensembl: ENSG000001678957   OMIM: 6058295   UniProtKB: Q8IU683   

Export aliases for TMC8 gene to outside databases

Previous GC identifers: GC17P073639 GC17P071551


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TMC8 Gene:
Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility
to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin.
EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes
encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form
transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane
domains and 3 leucine zipper motifs. (provided by RefSeq, Jul 2008)

GeneCards Summary for TMC8 Gene: 
TMC8 (transmembrane channel-like 8) is a protein-coding gene. Diseases associated with TMC8 include epidermodysplasia verruciformis, and pityriasis versicolor. An important paralog of this gene is TMC7.

UniProtKB/Swiss-Prot: TMC8_HUMAN, Q8IU68
Function: Probable ion channel (By similarity)

Gene Wiki entry for TMC8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMC8 gene promoter:
         c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMC8 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMC8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMC8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

TMC8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMC8 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P076126:  view genomic region     (about GC identifiers)

Start:
76,126,851 bp from pter      End:
76,139,049 bp from pter
Size:
12,199 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TMC8_HUMAN, Q8IU68 (See protein sequence)
Recommended Name: Transmembrane channel-like protein 8  
Size: 726 amino acids; 81641 Da
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Sequence caution: Sequence=BAC03459.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BC028076; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites;
Secondary accessions: Q2YDC0 Q8IWU7 Q8N358 Q8NF04
Alternative splicing: 2 isoforms:  Q8IU68-1   Q8IU68-2   

Explore the universe of human proteins at neXtProt for TMC8: NX_Q8IU68

Explore proteomics data for TMC8 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IU68

  • TMC8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TMC8 Protein Expression
    REFSEQ proteins: NP_689681.2  
    ENSEMBL proteins: 
     ENSP00000467460   ENSP00000465049   ENSP00000325561   ENSP00000467482  

    Human Recombinant Protein Products for TMC8: 
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TMC8 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral to membrane IEA--

    TMC8 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR012496 TMC

    Graphical View of Domain Structure for InterPro Entry Q8IU68

    ProtoNet protein and cluster: Q8IU68

    1 Blocks protein domain: IPB012496 TMC

    UniProtKB/Swiss-Prot: TMC8_HUMAN, Q8IU68
    Similarity: Belongs to the TMC family


    TMC8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TMC8_HUMAN, Q8IU68
    Function: Probable ion channel (By similarity)

    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tmc8):

     behavior/neurological  cardiovascular system  other  pigmentation  vision/eye 

    TMC8 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TMC8 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TMC8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMC8 
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    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMC8
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate TMC8:
    hsa-miR-370 hsa-miR-3121-3p hsa-miR-181a-2* hsa-miR-1205
    SwitchGear 3'UTR luciferase reporter plasmidTMC8 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMC8


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMC8

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport IEA--

    TMC8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMC8

    Search CenterWatch for drugs/clinical trials and news about TMC8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TMC8 gene: 
    NM_152468.4  

    Unigene Cluster for TMC8:

    Transmembrane channel-like 8
    Hs.592102  [show with all ESTs]
    Unigene Representative Sequence: NM_152468
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000590426 ENST00000590799 ENST00000318430(uc010dhh.1 uc002jup.2 uc002juq.2 uc010wtr.1 uc002jur.1)
    ENST00000589691 ENST00000592399 ENST00000591983 ENST00000590184 ENST00000591003
    ENST00000591144
    miRNA
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    4 QIAGEN miScript miRNA Assays for microRNAs that regulate TMC8:
    hsa-miR-370 hsa-miR-3121-3p hsa-miR-181a-2* hsa-miR-1205
    SwitchGear 3'UTR luciferase reporter plasmidTMC8 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TMC8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMC8
    Clone
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    OriGene clones in human, mouse for TMC8 (see all 8)
    OriGene ORF clones in mouse, rat for TMC8
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    GenScript: all cDNA clones in your preferred vector: TMC8 (NM_152468)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMC8
    Sirion Biotech Customized lentivirus for stable overexpression of TMC8 
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMC8
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMC8

    Additional mRNA sequence: 

    AK090478.1 AK097987.1 AK128327.1 AK303499.1 AK310623.1 AL834508.1 AY057380.1 AY099358.1 
    AY099359.1 AY236500.1 BC110296.1 BC141865.1 

    8 DOTS entries:

    DT.410907  DT.95359051  DT.101973957  DT.91823948  DT.95286901  DT.95358433  DT.100747028  DT.121009541 

    24/100 AceView cDNA sequences (see all 100):

    AI801411 BU951034 AW291257 AW151554 AW071081 CR598574 AY057380 BQ052577 
    AW085753 BF902041 BP368131 C04782 AW445050 AI473525 BQ053854 AA814453 
    AY236500 AK128327 AW189764 AI673085 AA769392 AI333008 AW451331 AI766641 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for TMC8 (see all 12)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11a · 11b · 11c · 11d ^ 12a · 12b ^ 13 ^
    SP1:                                                  -                 -           -                                   -           -     -           -         
    SP2:                                                  -                                                                                                         
    SP3:                                                  -                 -           -                                                                           
    SP4:                                                  -     -     -     -           -                                                                           
    SP5:                                                                    -           -                                   -                                       

    ExUns: 14 ^ 15a · 15b
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for TMC8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMC8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCCTCCAAG
    TMC8 Expression
    About this image


    See TMC8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMC8

    SOURCE GeneReport for Unigene cluster: Hs.592102

    UniProtKB/Swiss-Prot: TMC8_HUMAN, Q8IU68
    Tissue specificity: Expressed in placenta, prostate and testis

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMC8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TMC8 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmc81 , 5 transmembrane channel-like gene family 81, 5 82.09(n)1
    79.8(a)1
      11 (82.96 cM)5
    2173561  NM_001195088.11  NP_001182017.11 
     1177820765 
    lizard
    (Anolis carolinensis)
    Reptilia TMC86
    transmembrane channel-like 8
    42(a)
    1 ↔ 1
    2(102320082-102342996)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000044621 transmembrane channel-like protein 7-like 48.7(n)
    34.53(a)
      100004462  XM_003199540.1  XP_003199588.1 


    ENSEMBL Gene Tree for TMC8 (if available)
    TreeFam Gene Tree for TMC8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TMC8 gene
    TMC72  TMC32  TMC22  TMC52  TMC42  TMC12  TMC62  
    2 SIMAP similar genes for TMC8 using alignment to 3 protein entries:     TMC8_HUMAN (see all proteins):
    TMC7    TMC4

    TMC8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/323 SNPs in TMC8 are shown (see all 323)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1219083301,2
    Cpathogenic177217195(+) AGCTGA/G/TAGAAC 2 E * stg11NA 4546
    rs1995028901,2
    C--71554772(+) CCGTCA/GCTTCC 2 H R mis10--------
    rs1499974701,2
    C,F--71554846(+) ACGTAC/TTCAAC 2 L F mis11Minor allele frequency- T:0.00NA 4446
    rs72084221,2,4
    C,F,A,H--71554850(+) ACTCAT/ACGGGC 2 /N /I mis1 ese335Minor allele frequency- A:0.44NS EA NA WA CSA EU 8712
    rs1492032281,2
    C,F--71554851(+) CTCAAC/TGGGCT 2 N syn12Minor allele frequency- T:0.00NA EU 5709
    rs2005372771,2
    --71554852(+) TCAACA/GGGCTC 2 R G mis10--------
    rs1467903291,2
    C--71554949(+) AATCCC/TGGCCA 1 -- int10--------
    rs1156320281,2
    F--71555014(+) TCAGAG/AAGGTT 1 -- int11Minor allele frequency- A:0.03WA 118
    rs1405555011,2
    --71555032(+) TCGTGA/GCCACA 1 -- int10--------
    rs752401671,2
    F--71555044(+) GTCACG/AGCCAA 1 -- int11Minor allele frequency- A:0.50NA 4

    HapMap Linkage Disequilibrium report for TMC8 (76126851 - 76139049 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for TMC8:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv3277n71CNV Loss21882294
    nsv908871CNV Loss21882294
    dgv3275n71CNV Loss21882294
    nsv515500CNV Loss19592680
    nsv908860CNV Loss21882294
    nsv470607CNV Loss18288195
    dgv3276n71CNV Loss21882294
    dgv3278n71CNV Loss21882294
    nsv908872CNV Gain21882294
    nsv833554CNV Gain+Loss17160897


    Human Gene Mutation Database (HGMD): TMC8

    Locus Specific Mutation Databases (LSDB): TMC8
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TMC8
    DNA2.0 Custom Variant and Variant Library Synthesis for TMC8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605829   
    OMIM disorders: 226400  
    UniProtKB/Swiss-Prot: TMC8_HUMAN, Q8IU68
  • Epidermodysplasia verruciformis (EV) [MIM:226400]: Rare autosomal recessive genodermatosis associated
    with a high risk of skin carcinoma that results from an abnormal susceptibility to infection by specific human
    papillomaviruses. Infection leads to persistent wart-like or macular lesions. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • 7 diseases for TMC8:    About MalaCards
    epidermodysplasia verruciformis    pityriasis versicolor    squamous cell carcinoma    skin cancer
    cervical cancer    cervicitis    prostatitis

    3 diseases from the University of Copenhagen DISEASES database for TMC8:
    Epidermodysplasia verruciformis     Pityriasis versicolor     Skin cancer

    TMC8 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for TMC8 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    epidermodysplasia verruciformis 95.2 6 19706093 (2), 16045695 (1), 12906855 (1), 17368633 (1)
    skin carcinoma 77.9 1 12812529 (1)

    Human Genome Epidemiology (HuGE) Navigator: TMC8 (2 documents)

    Export disorders for TMC8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMC8 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with TMC8)
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    1. Mutations in two adjacent novel genes are associated with epidermodysplasia verruciformis. (PubMed id 12426567)1, 2, 3, 9 Ramoz N.... Favre M. (2002)
    2. Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis. (PubMed id 12906855)1, 2, 9 Kurima K.... Griffith A.J. (2003)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Cutaneous human papillomavirus infection, the EVER2 gene and incidence of squamous cell carcinoma: a case-control study. (PubMed id 18224692)1, 9 Patel A.S....Nelson H.H. (2008)
    5. Autosomal dominant epidermodysplasia verruciformis la cking a known EVER1 or EVER2 mutation. (PubMed id 19706093)1, 9 McDermott D.F....Hwang S.T. (2009)
    6. Regulation of cellular zinc balance as a potential mechanism of EVER-mediated protection against pathogenesis by cutaneous oncogenic human papillomaviruses. (PubMed id 18158319)1, 9 Lazarczyk M....Favre M. (2008)
    7. TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins. (PubMed id 12812529)1, 9 Keresztes G.... Heller S. (2003)
    8. EVER2 deficiency is associated with mild T-cell abnorm alities. (PubMed id 22903682)1 Crequer A....Jouanguy E. (2013)
    9. EVER2 protein binds TRADD to promote TNF-a-induced apo ptosis. (PubMed id 23429285)1 Gaud G....Vuillier F. (2013)
    10. Lack of EVER2 protein in two epidermodysplasia verruci formis patients with skin cancer presenting previously unreported homozygous gen etic deletions in the EVER2 gene. (PubMed id 22158547)1 Landini M.M....Gariglio M. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 147138 HGNC: 20474 AceView: EVER2 Ensembl:ENSG00000167895 euGenes: HUgn147138
    ECgene: TMC8 H-InvDB: TMC8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMC8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TMC8 Genetics and Cytogenetics in Oncology and Haematology
    TMC8basehttp://bioinf.uta.fi/TMC8base/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TMC8 gene:
    Search GeneIP for patents involving TMC8

    GeneCards and IP:
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