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Aliases for TMC8 Gene

Aliases for TMC8 Gene

  • Transmembrane Channel-Like 8 2 3
  • Epidermodysplasia Verruciformis Protein 2 3 4
  • Epidermodysplasia Verruciformis 2 2 3
  • EVER2 3 4
  • EVIN2 3 4
  • EV2 3

External Ids for TMC8 Gene

Previous HGNC Symbols for TMC8 Gene

  • EVER2

Previous GeneCards Identifiers for TMC8 Gene

  • GC17P073639
  • GC17P076126
  • GC17P071551

Summaries for TMC8 Gene

Entrez Gene Summary for TMC8 Gene

  • Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs. [provided by RefSeq, Jul 2008]

GeneCards Summary for TMC8 Gene

TMC8 (Transmembrane Channel-Like 8) is a Protein Coding gene. Diseases associated with TMC8 include epidermodysplasia verruciformis and superficial mycosis. GO annotations related to this gene include receptor binding. An important paralog of this gene is TMC7.

UniProtKB/Swiss-Prot for TMC8 Gene

  • Probable ion channel.

Gene Wiki entry for TMC8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMC8 Gene

Genomics for TMC8 Gene

Regulatory Elements for TMC8 Gene

Transcription factor binding sites by QIAGEN in the TMC8 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMC8 Gene

78,128,851 bp from pter
78,142,968 bp from pter
14,118 bases
Plus strand

Genomic View for TMC8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMC8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMC8 Gene

Proteins for TMC8 Gene

  • Protein details for TMC8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane channel-like protein 8
    Protein Accession:
    Secondary Accessions:
    • Q2YDC0
    • Q8IWU7
    • Q8N358
    • Q8NF04

    Protein attributes for TMC8 Gene

    726 amino acids
    Molecular mass:
    81641 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC03459.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BC028076; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMC8 Gene


neXtProt entry for TMC8 Gene

Proteomics data for TMC8 Gene at MOPED

Post-translational modifications for TMC8 Gene

  • Glycosylation at Asn 148 and Asn 567
  • Modification sites at PhosphoSitePlus

Other Protein References for TMC8 Gene

No data available for DME Specific Peptides for TMC8 Gene

Domains & Families for TMC8 Gene

Gene Families for TMC8 Gene

Protein Domains for TMC8 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMC family.
  • Belongs to the TMC family.
genes like me logo Genes that share domains with TMC8: view

Function for TMC8 Gene

Molecular function for TMC8 Gene

UniProtKB/Swiss-Prot Function:
Probable ion channel.

Gene Ontology (GO) - Molecular Function for TMC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 23429285
GO:0005515 protein binding IPI 18158319
genes like me logo Genes that share ontologies with TMC8: view
genes like me logo Genes that share phenotypes with TMC8: view

Animal Model Products

miRNA for TMC8 Gene

miRTarBase miRNAs that target TMC8

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMC8

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TMC8 Gene

Localization for TMC8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMC8 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMC8 Gene COMPARTMENTS Subcellular localization image for TMC8 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
golgi apparatus 5
nucleus 5

Gene Ontology (GO) - Cellular Components for TMC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005737 cytoplasm IDA 12426567
GO:0005783 endoplasmic reticulum IDA 12426567
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005794 Golgi apparatus IDA 18158319
genes like me logo Genes that share ontologies with TMC8: view

Pathways & Interactions for TMC8 Gene

SuperPathways for TMC8 Gene

No Data Available

Interacting Proteins for TMC8 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000325561 for TMC8 Gene via STRING

Gene Ontology (GO) - Biological Process for TMC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth IDA 18158319
GO:0006811 ion transport IEA --
GO:0032091 negative regulation of protein binding IDA 23429285
GO:0032460 negative regulation of protein oligomerization IDA 23429285
GO:0055069 zinc ion homeostasis IDA 18158319
genes like me logo Genes that share ontologies with TMC8: view

No data available for Pathways by source and SIGNOR curated interactions for TMC8 Gene

Drugs & Compounds for TMC8 Gene

No Compound Related Data Available

Transcripts for TMC8 Gene

Unigene Clusters for TMC8 Gene

Transmembrane channel-like 8:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMC8

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMC8 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11a · 11b · 11c · 11d ^ 12a · 12b ^ 13 ^
SP1: - - - - - - -
SP2: -
SP3: - - -
SP4: - - - - -
SP5: - - -
SP6: - - -
SP7: - -
SP9: - -
SP10: -

ExUns: 14 ^ 15a · 15b

Relevant External Links for TMC8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMC8 Gene

mRNA expression in normal human tissues for TMC8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMC8 Gene

This gene is overexpressed in Whole Blood (x13.1), Spleen (x10.9), and Small Intestine - Terminal Ileum (x5.0).

Protein differential expression in normal tissues from HIPED for TMC8 Gene

This gene is overexpressed in Bone marrow stromal cell (41.2), Peripheral blood mononuclear cells (11.4), and Plasma (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMC8 Gene

SOURCE GeneReport for Unigene cluster for TMC8 Gene Hs.592102

mRNA Expression by UniProt/SwissProt for TMC8 Gene

Tissue specificity: Expressed in placenta, prostate and testis.
genes like me logo Genes that share expression patterns with TMC8: view

Protein tissue co-expression partners for TMC8 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

Orthologs for TMC8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMC8 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMC8 35
  • 85.55 (n)
  • 83.4 (a)
TMC8 36
  • 82 (a)
(Canis familiaris)
Mammalia TMC8 35
  • 84.56 (n)
  • 80.37 (a)
TMC8 36
  • 79 (a)
(Mus musculus)
Mammalia Tmc8 35
  • 82.05 (n)
  • 79.8 (a)
Tmc8 16
Tmc8 36
  • 79 (a)
(Pan troglodytes)
Mammalia TMC8 35
  • 98.57 (n)
  • 97.93 (a)
TMC8 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Tmc8 35
  • 81.78 (n)
  • 77.97 (a)
(Monodelphis domestica)
Mammalia TMC8 36
  • 63 (a)
(Anolis carolinensis)
Reptilia TMC8 36
  • 42 (a)
(Danio rerio)
Actinopterygii TMC8 36
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
Species with no ortholog for TMC8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMC8 Gene

Gene Tree for TMC8 (if available)
Gene Tree for TMC8 (if available)

Paralogs for TMC8 Gene

Paralogs for TMC8 Gene

(2) SIMAP similar genes for TMC8 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TMC8: view

Variants for TMC8 Gene

Sequence variations from dbSNP and Humsavar for TMC8 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs369764 -- 78,141,117(+) ACCCC(G/T)ACCCC utr-variant-3-prime, nc-transcript-variant
rs412611 -- 78,136,178(-) gTTGC(A/G)TGTTA intron-variant
rs454138 -- 78,141,256(+) CCCAG(C/G)GGCAG utr-variant-3-prime, nc-transcript-variant
rs2871647 -- 78,141,396(-) AGAAC(A/C)CATTC utr-variant-3-prime, nc-transcript-variant
rs3169565 -- 78,142,883(+) AAACT(C/T)TGGGC utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for TMC8 Gene

Variant ID Type Subtype PubMed ID
nsv833554 CNV Gain+Loss 17160897
nsv908860 CNV Loss 21882294
dgv3275n71 CNV Loss 21882294
dgv3276n71 CNV Loss 21882294
dgv3277n71 CNV Loss 21882294
dgv3278n71 CNV Loss 21882294
nsv908871 CNV Loss 21882294
nsv515500 CNV Loss 19592680
nsv470607 CNV Loss 18288195
nsv908872 CNV Gain 21882294

Variation tolerance for TMC8 Gene

Residual Variation Intolerance Score: 53.78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.97; 68.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMC8 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMC8 Gene

Disorders for TMC8 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TMC8 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
epidermodysplasia verruciformis
  • lewandowsky-lutz syndrome
superficial mycosis
  • piedra
pityriasis versicolor
  • infection by pityrosporum furfur
- elite association
Search TMC8 in MalaCards View complete list of genes associated with diseases


  • Epidermodysplasia verruciformis (EV) [MIM:226400]: Rare autosomal recessive genodermatosis associated with a high risk of skin carcinoma that results from an abnormal susceptibility to infection by specific human papillomaviruses. Infection leads to persistent wart-like or macular lesions. {ECO:0000269 PubMed:12426567}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for TMC8

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TMC8: view

No data available for Genatlas for TMC8 Gene

Publications for TMC8 Gene

  1. Mutations in two adjacent novel genes are associated with epidermodysplasia verruciformis. (PMID: 12426567) Ramoz N. … Favre M. (Nat. Genet. 2002) 2 23 67
  2. Autosomal dominant epidermodysplasia verruciformis lacking a known EVER1 or EVER2 mutation. (PMID: 19706093) McDermott D.F. … Hwang S.T. (Pediatr Dermatol 2009) 23 67
  3. The EVER proteins as a natural barrier against papillomaviruses: a new insight into the pathogenesis of human papillomavirus infections. (PMID: 19487731) Lazarczyk M. … Favre M. (Microbiol. Mol. Biol. Rev. 2009) 23 67
  4. Regulation of cellular zinc balance as a potential mechanism of EVER-mediated protection against pathogenesis by cutaneous oncogenic human papillomaviruses. (PMID: 18158319) Lazarczyk M. … Favre M. (J. Exp. Med. 2008) 23 67
  5. Cutaneous human papillomavirus infection, the EVER2 gene and incidence of squamous cell carcinoma: a case-control study. (PMID: 18224692) Patel A.S. … Nelson H.H. (Int. J. Cancer 2008) 23 67

Products for TMC8 Gene

Sources for TMC8 Gene

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