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TMC7 Gene

protein-coding   GIFtS: 48
GCID: GC16P018995

Transmembrane Channel-Like 7

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Channel-Like 71 2
Transmembrane Channel-Like Protein 72

External Ids:    HGNC: 230001   Entrez Gene: 799052   Ensembl: ENSG000001705377   UniProtKB: Q7Z4023   

Export aliases for TMC7 gene to outside databases

Previous GC identifers: GC16P018922 GC16P018961 GC16P018902 GC16P017531


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMC7 Gene:
TMC7 (transmembrane channel-like 7) is a protein-coding gene. Diseases associated with TMC7 include epidermodysplasia verruciformis, and endotheliitis. An important paralog of this gene is TMC3.

UniProtKB/Swiss-Prot: TMC7_HUMAN, Q7Z402
Function: Probable ion channel (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NT_187260.1  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMC7 gene promoter:
         ATF-2   Zic1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMC7 promoter sequence
   Search Chromatin IP Primers for TMC7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMC7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12.3   Ensembl cytogenetic band:  16p12.3   HGNC cytogenetic band: 16p13.11

TMC7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMC7 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P018995:  view genomic region     (about GC identifiers)

Start:
18,995,256 bp from pter      End:
19,075,264 bp from pter
Size:
80,009 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TMC7_HUMAN, Q7Z402 (See protein sequence)
Recommended Name: Transmembrane channel-like protein 7  
Size: 723 amino acids; 83502 Da
Sequence caution: Sequence=BAB15032.1; Type=Erroneous initiation;
Secondary accessions: Q5H9Q8 Q7Z5M4 Q86WX0 Q9H766

Explore the universe of human proteins at neXtProt for TMC7: NX_Q7Z402

Explore proteomics data for TMC7 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn24, Asn84, Asn96, Asn259, Asn638
  • Modification sites at PhosphoSitePlus

  • See TMC7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001153836.1  NP_079123.3  

    ENSEMBL proteins: 
     ENSP00000455041   ENSP00000304710   ENSP00000397081  

    TMC7 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for TMC7

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    Abcam antibodies for TMC7
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    ThermoFisher Antibodies for TMC7
    LSBio Antibodies in human, mouse, rat for TMC7

    TMC7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TMC7
    Cloud-Clone Corp. CLIAs for TMC7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR012496 TMC

    Graphical View of Domain Structure for InterPro Entry Q7Z402

    ProtoNet protein and cluster: Q7Z402

    1 Blocks protein domain: IPB012496 TMC

    UniProtKB/Swiss-Prot: TMC7_HUMAN, Q7Z402
    Similarity: Belongs to the TMC family


    TMC7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TMC7_HUMAN, Q7Z402
    Function: Probable ion channel (By similarity)

    Phenotypes:
         1 GenomeRNAi human phenotype for TMC7:

     Decreased TP53 protein express 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMC7
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMC7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMC7

    miRNA
    Products:
        
    miRTarBase miRNAs that target TMC7:
    hsa-mir-26b-5p (MIRT028859), hsa-mir-191-5p (MIRT004688), hsa-mir-15b-5p (MIRT046404)

    Block miRNA regulation of human, mouse, rat TMC7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TMC7 (see all 51):
    hsa-miR-4307 hsa-let-7d hsa-miR-15a hsa-miR-503 hsa-miR-25 hsa-miR-374a hsa-miR-30d hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidTMC7 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TMC7
    Predesigned siRNA for gene silencing in human, mouse, rat TMC7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TMC7

    Clone
    Products:
         
    OriGene clones in human, mouse for TMC7 (see all 12)
    OriGene ORF clones in mouse, rat for TMC7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TMC7 (NM_024847)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMC7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMC7

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for TMC7
    Browse ESI BIO Cell Lines and PureStem Progenitors for TMC7 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMC7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TMC7_HUMAN, Q7Z402: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    cytosol1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    TMC7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMC7
    Interactions:

        Search GeneGlobe Interaction Network for TMC7

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for TMC7 (ENSP000003047104) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport IEA--

    TMC7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMC7



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TMC7 gene (2 alternative transcripts): 
    NM_001160364.2  NM_024847.4  

    Unigene Clusters for TMC7:

    Transmembrane channel-like 7
    Hs.187377  [show with all ESTs], Hs.531661
    Unigene Representative Sequences: NM_001160364, AF088010
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000569532(uc002dfp.2) ENST00000304381 ENST00000568469(uc010vao.1)
    ENST00000421369(uc002dfq.3 uc010vap.2) ENST00000561963
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TMC7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TMC7 (see all 51):
    hsa-miR-4307 hsa-let-7d hsa-miR-15a hsa-miR-503 hsa-miR-25 hsa-miR-374a hsa-miR-30d hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidTMC7 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TMC7
    Predesigned siRNA for gene silencing in human, mouse, rat TMC7
    Clone
    Products:
         
    OriGene clones in human, mouse for TMC7 (see all 12)
    OriGene ORF clones in mouse, rat for TMC7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TMC7 (NM_024847)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMC7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMC7
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TMC7
    OriGene qSTAR qPCR primer pairs in human, mouse for TMC7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMC7
      QuantiTect SYBR Green Assays in human, mouse, rat TMC7
      QuantiFast Probe-based Assays in human, mouse, rat TMC7

    Additional mRNA sequence: AF088010.1 

    5 DOTS entries:

    DT.427803  DT.120655954  DT.100014280  DT.40112712  DT.91732853 

    Selected AceView cDNA sequences (see all 33):

    BE672072 AA926961 AY236498 AA770338 BX383607 AW589791 BC047719 AY263165 
    AA715319 NM_024847 CB989922 BX330918 AV724411 AK024893 AK094664 BM563259 
    BC036205 CD642173 AW964097 BQ893727 BX091374 BI549341 AA382708 AA503453 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMC7 expression in normal human tissues (normalized intensities)      TMC7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAGTGCTAC
    TMC7 Expression
    About this image


    TMC7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Endothelium (Cardiovascular System)
             Adult Endothelial Cells Blood Brain Barrier
     
     Inner Cell Mass (Early Embryonic Tissues)
             Blimp1- mVenus and stella-ECFP genetically modified stem cells
     
     Brain (Nervous System)
             Adult Endothelial Cells Blood Brain Barrier
    TMC7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMC7 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.187377 Hs.531661
        Custom PCR Arrays for TMC7
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TMC7
    OriGene qSTAR qPCR primer pairs in human, mouse for TMC7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMC7
    QuantiTect SYBR Green Assays in human, mouse, rat TMC7
    QuantiFast Probe-based Assays in human, mouse, rat TMC7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMC7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TMC7 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmc71 , 5 transmembrane channel-like gene family 71, 5 85.58(n)1
    91.52(a)1
      7 (63.44 cM)5
    2097601  NM_172476.41  NP_766064.21 
     1185358435 
    chicken
    (Gallus gallus)
    Aves TMC71 transmembrane channel-like 7 64.31(n)
    60.03(a)
      416610  NM_001030641.1  NP_001025812.1 
    lizard
    (Anolis carolinensis)
    Reptilia TMC76
    transmembrane channel-like 7
    61(a)
    1 ↔ 1
    GL344017.1(52985-72848)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.139012 Xenopus laevis transcribed sequence with weak similarity more 72.8(n)    BJ058818.1 


    ENSEMBL Gene Tree for TMC7 (if available)
    TreeFam Gene Tree for TMC7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TMC7 gene
    TMC32  TMC22  TMC82  TMC52  TMC42  TMC12  TMC62  
    2 SIMAP similar genes for TMC7 using alignment to 3 protein entries:     TMC7_HUMAN (see all proteins):
    TMC8    TMC4

    TMC7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMC7 (see all 1912)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs99322901,2
    C,F,H--18993315(+) tccgcC/Ttcctg 1 -- us2k1 tfbs36Minor allele frequency- T:0.25NA WA CSA 16
    rs99216251,2
    C,F,H--18993417(+) tagagG/Acaggg 1 -- us2k17Minor allele frequency- A:0.22NA WA CSA 18
    rs1502174941,2
    C--18993455(+) GAACTC/GCTGAC 1 -- us2k10--------
    rs562497831,2
    C--18993538(+) TTTTT-/TTAAATG 1 -- us2k10--------
    rs1823900921,2
    --18993639(+) TATGAC/TCACAG 2 -- us2k10--------
    rs356185621,2
    C--18993733(+) TTTTT-/TGAGAT 2 -- us2k12Minor allele frequency- T:0.25NA CSA 4
    rs1861171571,2
    --18993879(+) CGCCAA/CCATGC 2 -- us2k10--------
    rs1893937131,2
    --18993924(+) GGTTTC/TGCCAT 2 -- us2k10--------
    rs1813505001,2
    --18994024(+) ATCCCA/GGATGA 2 -- us2k10--------
    rs1855666781,2
    --18994140(+) AAGGAC/TGTCGC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for TMC7 (18995256 - 19075264 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TMC7 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509603CNV Insertion20534489
    nsv436835CNV Insertion17901297
    esv27011CNV Loss19812545
    nsv9387CNV Loss18304495
    nsv817724CNV Gain17921354
    nsv905556CNV Gain21882294
    esv34419CNV Gain17911159
    dgv2640n71CNV Gain21882294
    nsv905565CNV Gain21882294
    esv587CNV CNV17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TMC7
    DNA2.0 Custom Variant and Variant Library Synthesis for TMC7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for TMC7:    About MalaCards
    epidermodysplasia verruciformis    endotheliitis


    TMC7 for disorders           About GeneDecksing


    Export disorders for TMC7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMC7 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TMC7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins. (PubMed id 12812529)1, 2, 3 Keresztes G.... Heller S. (BMC Genomics 2003)
    2. Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis. (PubMed id 12906855)1, 2, 3 Kurima K.... Griffith A.J. (Genomics 2003)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker. (PubMed id 22566498)1 Turner S.T....Boerwinkle E. (Hypertension 2012)
    5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    6. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79905 HGNC: 23000 AceView: TMC7 Ensembl:ENSG00000170537 euGenes: HUgn79905
    ECgene: TMC7 H-InvDB: TMC7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TMC7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMC7 gene:
    Search GeneIP for patents involving TMC7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TMC7  
     OriGene qPCR primer pairs and template standards for TMC7   Browse OriGene Protein Over-expression Lysates  
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     OriGene Custom Antibody Services for TMC7   OriGene Custom Protein Services for TMC7  

     
     
     Block miRNA regulation of human, mouse, rat TMC7 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TMC7
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMC7 Predesigned siRNA for gene silencing in human, mouse, rat TMC7
     QuantiFast Probe-based Assays in human, mouse, rat TMC7 QuantiTect SYBR Green Assays in human, mouse, rat TMC7
     Custom PCR Arrays for TMC7 Search Chromatin IP Primers for TMC7
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     GenScript Custom Purified and Recombinant Proteins Services for TMC7 GenScript cDNA clones with any tag delivered in your preferred vector for TMC7
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     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
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     Search Tocris compounds for TMC7
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     Novus Tissue Slides
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     Browse ESI BIO Cell Lines and PureStem Progenitors for TMC7
     Gene Synthesis
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMC7
     SwitchGear 3'UTR luciferase reporter plasmids for TMC7
     SwitchGear Promoter luciferase reporter plasmids for TMC7
     ThermoFisher Antibodies for TMC7
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMC7
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMC7
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TMC7
     LSBio Antibodies in human, mouse, rat for TMC7
    Customized transgenic rodents for:
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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