TMC7 Gene
protein-coding GIFtS: 46
GCID: GC16P018995
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transmembrane channel-like 7
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Aliases
for TMC7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Channel-Like 71 2 | | FLJ212401 | | Transmembrane Channel-Like Protein 72 |
Export aliases for TMC7 gene to outside databasesPrevious GC identifers: GC16P018922 GC16P018961 GC16P018902 GC16P017531 |
Summaries
for TMC7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TMC7_HUMAN, Q7Z402Function: Probable ion channel (By similarity)
|
Genomic Views
for TMC7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMC7 gene promoter:
ATF-2 Zic1 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMC7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMC7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p12.3 Ensembl cytogenetic band: 16p12.3 HGNC cytogenetic band: 16p13.11TMC7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P018995: view genomic region
(about GC identifiers)
Start:
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18,995,256 bp from pter |
End:
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19,075,264 bp from pter |
Size:
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80,009 bases |
Orientation:
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plus strand |
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Proteins
for TMC7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TMC7_HUMAN, Q7Z402 (See
protein sequence)Recommended Name: Transmembrane channel-like protein 7 Size: 723 amino acids; 83502 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=BAB15032.1; Type=Erroneous initiation;
Secondary accessions: Q5H9Q8 Q7Z5M4 Q86WX0 Q9H766Explore the universe of human proteins at neXtProt for TMC7: NX_Q7Z402
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q7Z402
TMC7 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001153836.1 NP_079123.3
ENSEMBL proteins: ENSP00000455041 ENSP00000304710 ENSP00000397081
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
TMC7 for ontologies About GeneDecksing
TMC7 Antibody Products:
Assay Products for TMC7: |
Protein
Domains /
Families
for TMC7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMC7 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q7Z402ProtoNet protein and cluster: Q7Z402 1 Blocks protein family: IPB012496 TMC
UniProtKB/Swiss-Prot: TMC7_HUMAN, Q7Z402Similarity: Belongs to the TMC family |
Function
for TMC7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TMC7_HUMAN, Q7Z402Function: Probable ion channel (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMC7 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMC7 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): TMC7 (NM_024847) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMC7 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMC7 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMC7 |
1 GenomeRNAi human phenotype for TMC7:
|
Pathways & Interactions
for TMC7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMC7
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for TMC7 (ENSP000003047104) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for TMC7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMC7
Search CenterWatch for drugs/clinical trials and news about TMC7
|
Transcripts
for TMC7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMC7 gene (2 alternative transcripts): NM_001160364.1 NM_024847.3 Unigene Clusters for TMC7: Transmembrane channel-like 7 Hs.187377 [show with all ESTs], Hs.531661 Unigene Representative Sequences: NM_001160364, AF0880105 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000569532(uc002dfp.2) ENST00000304381 ENST00000568469(uc010vao.1)
ENST00000421369(uc002dfq.3 uc010vap.2) ENST00000561963
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMC7 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMC7 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): TMC7 (NM_024847) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMC7 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMC7 |
Additional cDNA sequence: AF088010.1 5 DOTS entries: DT.427803 DT.120655954 DT.100014280 DT.40112712 DT.91732853 24/33 AceView cDNA sequences (see all 33): AA770338 AA926961 BC047719 BX383607 AW589791 BE672072 AY236498 CB989922 AK094664 AK024893 AY263165 NM_024847 BC036205 CD642173 AA715319 BX330918 AV724411 BM563259 BX091374 AA503453 AI621343 AA382708 BQ893727 AW964097
GeneLoc Exon Structure
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Expression
for TMC7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMC7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAGTGCTAC
About this image
See TMC7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMC7
SOURCE GeneReport for Unigene clusters: Hs.187377 Hs.531661
SABiosciences Custom PCR Arrays for TMC7
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMC7
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMC7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMC7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMC7 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMC7 |
Orthologs
for TMC7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TMC7 gene from 5/17 species (see all 17) About this table
ENSEMBL Gene Tree for TMC7 (if available)
TreeFam Gene Tree for TMC7 (if available) |
Paralogs
for TMC7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TMC7 gene
- TMC32 TMC22 TMC82 TMC52 TMC62 TMC12 TMC42
2 SIMAP similar genes for TMC7 using alignment to 3 protein entries: TMC7_HUMAN (see all proteins):TMC8 TMC4
TMC7 for paralogs About GeneDecksing
|
Genomic Variants
for TMC7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMC7 (18995256 - 19075264 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 10 variations for TMC7
10 CNVs: 32095 87994 77220 9757 72496 3994 87992 87993 3112 8816 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMC7 |
|
Disorders
/ Diseases
for TMC7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TMC7 for disorders About GeneDecksing
2  diseases for TMC7: About MalaCardsepidermodysplasia verruciformis hearing loss
Export disorders for TMC7 gene to outside databases
|
Publications
for TMC7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMC7 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMC7) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins. (PubMed id 12812529)1, 2, 3 Keresztes G.... Heller S. (2003)
- Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis. (PubMed id 12906855)1, 2, 3 Kurima K.... Griffith A.J. (2003)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker. (PubMed id 22566498)1 Turner S.T....Boerwinkle E. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for TMC7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing TMC7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMC7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMC7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMC7 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMC7 gene:
Search GeneIP for patents involving TMC7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMC7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TMC7 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMC7 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMC7 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMC7 | | OriGene 3'-UTR Clone for TMC7 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMC7 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMC7 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TMC7 | | OriGene Custom Protein Services for TMC7 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMC7 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMC7 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMC7 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMC7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMC7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMC7 |
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 |  |  |  | |
| | | | Search Tocris compounds for TMC7 |
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 | | | TMC7 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMC7 |
|  |  |  | | | | ThermoFisher Antibodies for TMC7 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMC7 |
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