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Aliases for TMC7 Gene

Aliases for TMC7 Gene

  • Transmembrane Channel-Like 7 2 3

External Ids for TMC7 Gene

Summaries for TMC7 Gene

GeneCards Summary for TMC7 Gene

TMC7 (Transmembrane Channel-Like 7) is a Protein Coding gene. An important paralog of this gene is TMC5.

UniProtKB/Swiss-Prot for TMC7 Gene

  • Probable ion channel.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMC7 Gene

Genomics for TMC7 Gene

Genomic Location for TMC7 Gene

Start:
18,983,934 bp from pter
End:
19,063,942 bp from pter
Size:
80,009 bases
Orientation:
Plus strand

Genomic View for TMC7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMC7 Gene

Regulatory Elements for TMC7 Gene

Proteins for TMC7 Gene

  • Protein details for TMC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z402-TMC7_HUMAN
    Recommended name:
    Transmembrane channel-like protein 7
    Protein Accession:
    Q7Z402
    Secondary Accessions:
    • E7ERB6
    • Q5H9Q8
    • Q7Z5M4
    • Q86WX0
    • Q9H766

    Protein attributes for TMC7 Gene

    Size:
    723 amino acids
    Molecular mass:
    83502 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15032.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMC7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMC7 Gene

Proteomics data for TMC7 Gene at MOPED

Post-translational modifications for TMC7 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn24, Asn84, Asn96, Asn259, and Asn638

Other Protein References for TMC7 Gene

No data available for DME Specific Peptides for TMC7 Gene

Domains for TMC7 Gene

Protein Domains for TMC7 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

TMC7_HUMAN
Family:
  • Belongs to the TMC family.:
    • Q7Z402
genes like me logo Genes that share domains with TMC7: view

No data available for Gene Families for TMC7 Gene

Function for TMC7 Gene

Molecular function for TMC7 Gene

UniProtKB/Swiss-Prot Function: Probable ion channel.

Phenotypes for TMC7 Gene

genes like me logo Genes that share phenotypes with TMC7: view

miRNA for TMC7 Gene

miRTarBase miRNAs that target TMC7

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMC7 Gene

Localization for TMC7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMC7 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMC7 Gene COMPARTMENTS Subcellular localization image for TMC7 gene
Compartment Confidence
plasma membrane 3
cytosol 1

Gene Ontology (GO) - Cellular Components for TMC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMC7: view

Pathways for TMC7 Gene

SuperPathways for TMC7 Gene

No Data Available

Interacting Proteins for TMC7 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000304710%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000304710 for TMC7 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for TMC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
genes like me logo Genes that share ontologies with TMC7: view

No data available for Pathways by source for TMC7 Gene

Transcripts for TMC7 Gene

Unigene Clusters for TMC7 Gene

Transmembrane channel-like 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMC7 Gene

No ASD Table

Relevant External Links for TMC7 Gene

GeneLoc Exon Structure for
TMC7
ECgene alternative splicing isoforms for
TMC7

Expression for TMC7 Gene

mRNA expression in normal human tissues for TMC7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMC7 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (5.6) and Brain - Substantia nigra (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TMC7 Gene

SOURCE GeneReport for Unigene cluster for TMC7 Gene Hs.187377

genes like me logo Genes that share expressions with TMC7: view

Orthologs for TMC7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMC7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMC7 36
  • 99.54 (n)
  • 99.17 (a)
TMC7 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMC7 36
  • 88.75 (n)
  • 90.87 (a)
TMC7 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMC7 36
  • 89.76 (n)
  • 92.12 (a)
TMC7 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmc7 36
  • 85.58 (n)
  • 91.52 (a)
Tmc7 16
Tmc7 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMC7 37
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMC7 37
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmc7 36
  • 85.54 (n)
  • 91.66 (a)
chicken
(Gallus gallus)
Aves TMC7 36
  • 64.31 (n)
  • 60.03 (a)
TMC7 37
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMC7 37
  • 61 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13901 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493700 36
  • 61.35 (n)
  • 59.74 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 40 (a)
OneToMany
Species with no ortholog for TMC7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMC7 Gene

ENSEMBL:
Gene Tree for TMC7 (if available)
TreeFam:
Gene Tree for TMC7 (if available)

Paralogs for TMC7 Gene

Paralogs for TMC7 Gene

Selected SIMAP similar genes for TMC7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TMC7: view

Variants for TMC7 Gene

Sequence variations from dbSNP and Humsavar for TMC7 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs3935231 -- 18,985,183(-) CTCCC(A/G)GGTTC intron-variant
rs4072393 -- 19,030,272(-) TCACC(C/T)CATCA frameshift-variant, intron-variant
rs4077848 -- 19,009,457(+) TGTTA(C/T)GGCCC intron-variant
rs4077849 -- 19,009,809(+) GGTGG(C/T)GGGTG intron-variant
rs4238668 -- 19,059,862(+) ATCCC(A/T)GCTAC intron-variant, utr-variant-3-prime, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TMC7 Gene

Variant ID Type Subtype PubMed ID
esv587 CNV CNV 17122850
dgv823e1 CNV Complex 17122850
esv34419 CNV Gain 17911159
nsv905556 CNV Gain 21882294
nsv436835 CNV Insertion 17901297
dgv2640n71 CNV Gain 21882294
nsv817724 CNV Gain 17921354
esv27011 CNV Loss 19812545
nsv9387 CNV Loss 18304495
nsv905565 CNV Gain 21882294
nsv509603 CNV Insertion 20534489

Relevant External Links for TMC7 Gene

HapMap Linkage Disequilibrium report
TMC7

Disorders for TMC7 Gene

No disorders were found for TMC7 Gene.

No data available for UniProtKB/Swiss-Prot for TMC7 Gene

Publications for TMC7 Gene

  1. TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins. (PMID: 12812529) Keresztes G. … Heller S. (BMC Genomics 2003) 2 3 4
  2. Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis. (PMID: 12906855) Kurima K. … Griffith A.J. (Genomics 2003) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3

Products for TMC7 Gene

Sources for TMC7 Gene

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