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Aliases for TMC7 Gene

Aliases for TMC7 Gene

  • Transmembrane Channel Like 7 2 3 5

External Ids for TMC7 Gene

Previous GeneCards Identifiers for TMC7 Gene

  • GC16P018922
  • GC16P018961
  • GC16P018902
  • GC16P017531

Summaries for TMC7 Gene

GeneCards Summary for TMC7 Gene

TMC7 (Transmembrane Channel Like 7) is a Protein Coding gene. An important paralog of this gene is TMC4.

UniProtKB/Swiss-Prot for TMC7 Gene

  • Probable ion channel.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMC7 Gene

Genomics for TMC7 Gene

Regulatory Elements for TMC7 Gene

Enhancers for TMC7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G018945 1.3 Ensembl ENCODE 11.8 -37.6 -37595 1.3 HDGF FOXA2 ATF1 ARNT DMAP1 FEZF1 ZNF48 ZNF143 MXD4 JUNB ENSG00000233024 PKD1P5 NPIPA8 ENSG00000205746 TMC7 ARL6IP1 COQ7 ENSG00000260352
GH16G019005 1.3 Ensembl ENCODE 8.1 +22.1 22104 1.7 PKNOX1 FOXA2 ATF1 MLX ARID4B SIN3A DMAP1 ZNF48 FOS ZNF202 COQ7 ENSG00000233024 TMC7 GC16P019012
GH16G018997 1.3 Ensembl ENCODE 6.7 +14.7 14724 3.3 FOXA2 PKNOX1 MLX ZFP64 SIN3A ARID4B DMAP1 SLC30A9 FOS SP5 COQ7 ENSG00000233024 TMC7 LOC102723385 GC16P019012
GH16G018969 1.2 Ensembl ENCODE 6.3 -14.6 -14601 0.7 FOXA2 MLX WRNIP1 SIN3A ARID4B FEZF1 ZNF2 SLC30A9 GLIS2 ZNF143 SMG1 RNU6-1340P COQ7 TMC7 ENSG00000260352
GH16G018983 1.1 ENCODE 6.7 +0.2 224 1.7 MLX ARNT ARID4B SIN3A ZNF2 ZNF143 ZNF263 SP5 ZHX2 MXD4 TMC7 COQ7 LOC102723385 GC16P019012
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMC7 on UCSC Golden Path with GeneCards custom track

Promoters for TMC7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000084126 166 1001 MLX ARNT ARID4B SIN3A ZNF2 ZNF143 ZNF263 SP5 ZHX2 MXD4

Genomic Location for TMC7 Gene

18,983,934 bp from pter
19,063,942 bp from pter
80,009 bases
Plus strand

Genomic View for TMC7 Gene

Genes around TMC7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMC7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMC7 Gene

Proteins for TMC7 Gene

  • Protein details for TMC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane channel-like protein 7
    Protein Accession:
    Secondary Accessions:
    • E7ERB6
    • Q5H9Q8
    • Q7Z5M4
    • Q86WX0
    • Q9H766

    Protein attributes for TMC7 Gene

    723 amino acids
    Molecular mass:
    83502 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB15032.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMC7 Gene


neXtProt entry for TMC7 Gene

Post-translational modifications for TMC7 Gene

  • Glycosylation at isoforms=24, posLast=8484, isoforms=96, posLast=259259, and Asn638
  • Modification sites at PhosphoSitePlus

Other Protein References for TMC7 Gene

No data available for DME Specific Peptides for TMC7 Gene

Domains & Families for TMC7 Gene

Gene Families for TMC7 Gene

Protein Domains for TMC7 Gene


Suggested Antigen Peptide Sequences for TMC7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMC family.
  • Belongs to the TMC family.
genes like me logo Genes that share domains with TMC7: view

Function for TMC7 Gene

Molecular function for TMC7 Gene

UniProtKB/Swiss-Prot Function:
Probable ion channel.
genes like me logo Genes that share phenotypes with TMC7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMC7 Gene

Localization for TMC7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMC7 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMC7 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TMC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMC7: view

Pathways & Interactions for TMC7 Gene

No Data Available

Interacting Proteins for TMC7 Gene

Gene Ontology (GO) - Biological Process for TMC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
genes like me logo Genes that share ontologies with TMC7: view

No data available for Pathways by source and SIGNOR curated interactions for TMC7 Gene

Transcripts for TMC7 Gene

Unigene Clusters for TMC7 Gene

Transmembrane channel-like 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMC7 Gene

No ASD Table

Relevant External Links for TMC7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMC7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMC7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMC7 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x5.6) and Brain - Substantia nigra (x4.3).

Protein differential expression in normal tissues from HIPED for TMC7 Gene

This gene is overexpressed in Urine (33.7), Heart (18.2), and Placenta (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMC7 Gene

Protein tissue co-expression partners for TMC7 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMC7 Gene:


SOURCE GeneReport for Unigene cluster for TMC7 Gene:


Evidence on tissue expression from TISSUES for TMC7 Gene

  • Nervous system(4.3)
  • Intestine(4.1)
genes like me logo Genes that share expression patterns with TMC7: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMC7 Gene

Orthologs for TMC7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMC7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMC7 34 35
  • 99.54 (n)
(Canis familiaris)
Mammalia TMC7 34 35
  • 89.76 (n)
(Bos Taurus)
Mammalia TMC7 34 35
  • 88.75 (n)
(Mus musculus)
Mammalia Tmc7 34 16 35
  • 85.58 (n)
(Rattus norvegicus)
Mammalia Tmc7 34
  • 85.54 (n)
(Monodelphis domestica)
Mammalia TMC7 35
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia TMC7 35
  • 67 (a)
(Gallus gallus)
Aves TMC7 34 35
  • 64.31 (n)
(Anolis carolinensis)
Reptilia TMC7 35
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493700 34
  • 61.35 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13901 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 40 (a)
Species where no ortholog for TMC7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMC7 Gene

Gene Tree for TMC7 (if available)
Gene Tree for TMC7 (if available)

Paralogs for TMC7 Gene

Paralogs for TMC7 Gene

(2) SIMAP similar genes for TMC7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TMC7: view

Variants for TMC7 Gene

Sequence variations from dbSNP and Humsavar for TMC7 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000015347 -- 19,020,935(+) CAATA(A/G)TTATG intron-variant
rs1000020848 -- 19,017,457(+) TATAT(G/T)ATTTT intron-variant
rs1000077161 -- 19,026,978(+) GCTGG(G/T)CTTGA intron-variant
rs1000082894 -- 19,053,639(+) CGCAG(C/G)TAATC intron-variant
rs1000106821 -- 19,013,712(+) CGGGG(C/T)TTCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMC7 Gene

Variant ID Type Subtype PubMed ID
dgv2787n100 CNV gain 25217958
esv27011 CNV loss 19812545
esv2758634 CNV gain+loss 17122850
esv34419 CNV gain 17911159
esv3570409 CNV gain 25503493
esv3638119 CNV loss 21293372
esv3892806 CNV gain 25118596
nsv1045019 CNV gain 25217958
nsv1047485 CNV gain 25217958
nsv1051531 CNV gain 25217958
nsv436835 CNV insertion 17901297
nsv509603 CNV insertion 20534489
nsv571579 CNV gain 21841781
nsv571580 CNV gain 21841781
nsv571582 CNV gain 21841781
nsv817724 CNV gain 17921354
nsv9387 CNV loss 18304495
nsv984286 CNV duplication 23825009

Variation tolerance for TMC7 Gene

Residual Variation Intolerance Score: 50.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.95; 74.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMC7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMC7 Gene

Disorders for TMC7 Gene

Relevant External Links for TMC7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMC7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMC7 Gene

Publications for TMC7 Gene

  1. TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins. (PMID: 12812529) Keresztes G. … Heller S. (BMC Genomics 2003) 2 3 4 64
  2. Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis. (PMID: 12906855) Kurima K. … Griffith A.J. (Genomics 2003) 2 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  5. Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker. (PMID: 22566498) Turner S.T. … Boerwinkle E. (Hypertension 2012) 3 64

Products for TMC7 Gene

Sources for TMC7 Gene

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