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Aliases for TMC5 Gene

Aliases for TMC5 Gene

  • Transmembrane Channel Like 5 2 3 5

External Ids for TMC5 Gene

Previous GeneCards Identifiers for TMC5 Gene

  • GC16P019379
  • GC16P019434
  • GC16P019375
  • GC16P019329
  • GC16P017959

Summaries for TMC5 Gene

GeneCards Summary for TMC5 Gene

TMC5 (Transmembrane Channel Like 5) is a Protein Coding gene. An important paralog of this gene is TMC4.

UniProtKB/Swiss-Prot for TMC5 Gene

  • Probable ion channel.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMC5 Gene

Genomics for TMC5 Gene

Regulatory Elements for TMC5 Gene

Enhancers for TMC5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMC5 on UCSC Golden Path with GeneCards custom track

Promoters for TMC5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMC5 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMC5 Gene

19,410,496 bp from pter
19,499,113 bp from pter
88,618 bases
Plus strand

Genomic View for TMC5 Gene

Genes around TMC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMC5 Gene

Proteins for TMC5 Gene

  • Protein details for TMC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane channel-like protein 5
    Protein Accession:
    Secondary Accessions:
    • Q68DK8
    • Q8IY20
    • Q8NHV6
    • Q9H8I7

    Protein attributes for TMC5 Gene

    1006 amino acids
    Molecular mass:
    114797 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB14629.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMC5 Gene


neXtProt entry for TMC5 Gene

Proteomics data for TMC5 Gene at MOPED

Post-translational modifications for TMC5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMC5 Gene

Domains & Families for TMC5 Gene

Gene Families for TMC5 Gene

Protein Domains for TMC5 Gene


Suggested Antigen Peptide Sequences for TMC5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMC family.
  • Belongs to the TMC family.
genes like me logo Genes that share domains with TMC5: view

Function for TMC5 Gene

Molecular function for TMC5 Gene

UniProtKB/Swiss-Prot Function:
Probable ion channel.

Phenotypes for TMC5 Gene

genes like me logo Genes that share phenotypes with TMC5: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMC5 Gene

Localization for TMC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMC5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMC5 Gene COMPARTMENTS Subcellular localization image for TMC5 gene
Compartment Confidence
extracellular 5
plasma membrane 3
nucleus 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for TMC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with TMC5: view

Pathways & Interactions for TMC5 Gene

SuperPathways for TMC5 Gene

No Data Available

Interacting Proteins for TMC5 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000379531 for TMC5 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for TMC5 Gene


No data available for Pathways by source and SIGNOR curated interactions for TMC5 Gene

Drugs & Compounds for TMC5 Gene

No Compound Related Data Available

Transcripts for TMC5 Gene

Unigene Clusters for TMC5 Gene

Transmembrane channel-like 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMC5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b · 19c
SP1: - -
SP2: - - -
SP3: - -
SP4: - - -
SP5: -
SP6: - -

Relevant External Links for TMC5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMC5 Gene

mRNA expression in normal human tissues for TMC5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMC5 Gene

This gene is overexpressed in Minor Salivary Gland (x11.3), Small Intestine - Terminal Ileum (x9.0), Colon - Transverse (x6.9), Stomach (x6.6), and Lung (x5.1).

Protein differential expression in normal tissues from HIPED for TMC5 Gene

This gene is overexpressed in Nasal epithelium (68.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMC5 Gene

SOURCE GeneReport for Unigene cluster for TMC5 Gene Hs.115838

genes like me logo Genes that share expression patterns with TMC5: view

Protein tissue co-expression partners for TMC5 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for TMC5 Gene

Orthologs for TMC5 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMC5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMC5 35
  • 84.41 (n)
  • 78.85 (a)
TMC5 36
  • 78 (a)
(Canis familiaris)
Mammalia TMC5 35
  • 85.19 (n)
  • 79.64 (a)
TMC5 36
  • 86 (a)
(Mus musculus)
Mammalia Tmc5 35
  • 80.3 (n)
  • 76.12 (a)
Tmc5 16
Tmc5 36
  • 75 (a)
(Pan troglodytes)
Mammalia TMC5 35
  • 98.94 (n)
  • 98.11 (a)
TMC5 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Tmc5 35
  • 79.57 (n)
  • 79.03 (a)
(Monodelphis domestica)
Mammalia TMC5 36
  • 52 (a)
(Ornithorhynchus anatinus)
Mammalia TMC5 36
  • 54 (a)
(Gallus gallus)
Aves TMC5 35
  • 60.06 (n)
  • 53.09 (a)
TMC5 36
  • 52 (a)
(Anolis carolinensis)
Reptilia TMC5 36
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmc5 35
  • 57.48 (n)
  • 52.4 (a)
(Danio rerio)
Actinopterygii LOC561497 35
  • 57.63 (n)
  • 47.92 (a)
TMC5 36
  • 43 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000578 35
  • 45.8 (n)
  • 30.94 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3280 36
  • 8 (a)
(Caenorhabditis elegans)
Secernentea tmc-1 36
  • 11 (a)
tmc-2 36
  • 13 (a)
Species with no ortholog for TMC5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMC5 Gene

Gene Tree for TMC5 (if available)
Gene Tree for TMC5 (if available)

Paralogs for TMC5 Gene

Paralogs for TMC5 Gene

(1) SIMAP similar genes for TMC5 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TMC5: view

Variants for TMC5 Gene

Sequence variations from dbSNP and Humsavar for TMC5 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs16972013 - 19,449,566(+) TGAAA(A/G)TGGTC reference, missense
rs36019638 - 19,460,249(+) TAATC(A/G)CATCC reference, missense
rs3898567 -- 19,458,025(+) atcca(A/G)ccTAA intron-variant
rs3905363 -- 19,421,241(-) TTAAC(A/G)TGATA intron-variant
rs8062507 -- 19,490,345(+) AATAA(C/T)CATCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMC5 Gene

Variant ID Type Subtype PubMed ID
nsv436835 CNV Insertion 17901297
nsv833162 CNV Loss 17160897
nsv905567 CNV Gain 21882294
esv27832 CNV Loss 19812545
nsv833163 CNV Gain 17160897
esv2714051 CNV Deletion 23290073
esv2714053 CNV Deletion 23290073
esv2116787 CNV Deletion 18987734
esv3792 CNV Deletion 18987735
esv2678457 CNV Deletion 23128226
esv2714054 CNV Deletion 23290073

Variation tolerance for TMC5 Gene

Residual Variation Intolerance Score: 93.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.59; 65.22% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TMC5 Gene

Disorders for TMC5 Gene

Relevant External Links for TMC5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMC5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMC5 Gene

Publications for TMC5 Gene

  1. TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins. (PMID: 12812529) Keresztes G. … Heller S. (BMC Genomics 2003) 2 3 4 67
  2. Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis. (PMID: 12906855) Kurima K. … Griffith A.J. (Genomics 2003) 2 3
  3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3
  4. A genome-wide association study of sleep habits and insomnia. (PMID: 23728906) Byrne E.M. … Wray N.R. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2013) 3
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3

Products for TMC5 Gene

Sources for TMC5 Gene