Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMC4 Gene

Aliases for TMC4 Gene

  • Transmembrane Channel Like 4 2 3 5

External Ids for TMC4 Gene

Previous GeneCards Identifiers for TMC4 Gene

  • GC19M059339
  • GC19M059355
  • GC19M054663
  • GC19M050980

Summaries for TMC4 Gene

GeneCards Summary for TMC4 Gene

TMC4 (Transmembrane Channel Like 4) is a Protein Coding gene. An important paralog of this gene is TMC5.

UniProtKB/Swiss-Prot for TMC4 Gene

  • Probable ion channel.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMC4 Gene

Genomics for TMC4 Gene

Regulatory Elements for TMC4 Gene

Enhancers for TMC4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMC4 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMC4 Gene

54,160,095 bp from pter
54,173,250 bp from pter
13,156 bases
Minus strand

Genomic View for TMC4 Gene

Genes around TMC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMC4 Gene

Proteins for TMC4 Gene

  • Protein details for TMC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane channel-like protein 4
    Protein Accession:
    Secondary Accessions:
    • Q7Z5M3
    • Q8N5E4
    • Q8TBS7

    Protein attributes for TMC4 Gene

    712 amino acids
    Molecular mass:
    79208 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMC4 Gene


neXtProt entry for TMC4 Gene

Proteomics data for TMC4 Gene at MOPED

Post-translational modifications for TMC4 Gene

  • Glycosylation at Asn 101
  • Modification sites at PhosphoSitePlus

Other Protein References for TMC4 Gene

No data available for DME Specific Peptides for TMC4 Gene

Domains & Families for TMC4 Gene

Gene Families for TMC4 Gene

Protein Domains for TMC4 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMC family.
  • Belongs to the TMC family.
genes like me logo Genes that share domains with TMC4: view

Function for TMC4 Gene

Molecular function for TMC4 Gene

UniProtKB/Swiss-Prot Function:
Probable ion channel.
genes like me logo Genes that share phenotypes with TMC4: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMC4 Gene

Localization for TMC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMC4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMC4 Gene COMPARTMENTS Subcellular localization image for TMC4 gene
Compartment Confidence
plasma membrane 3
peroxisome 2

Gene Ontology (GO) - Cellular Components for TMC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with TMC4: view

Pathways & Interactions for TMC4 Gene

SuperPathways for TMC4 Gene

No Data Available

Interacting Proteins for TMC4 Gene

Gene Ontology (GO) - Biological Process for TMC4 Gene


No data available for Pathways by source and SIGNOR curated interactions for TMC4 Gene

Drugs & Compounds for TMC4 Gene

No Compound Related Data Available

Transcripts for TMC4 Gene

Unigene Clusters for TMC4 Gene

Transmembrane channel-like 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMC4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^
SP1: - - - -
SP2: - - -
SP3: -
SP4: - - -
SP5: -
SP6: -

ExUns: 14a · 14b · 14c

Relevant External Links for TMC4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMC4 Gene

mRNA expression in normal human tissues for TMC4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMC4 Gene

This gene is overexpressed in Colon - Transverse (x6.9) and Pancreas (x5.5).

Protein differential expression in normal tissues from HIPED for TMC4 Gene

This gene is overexpressed in Nasal epithelium (63.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for TMC4 Gene

SOURCE GeneReport for Unigene cluster for TMC4 Gene Hs.355126

genes like me logo Genes that share expression patterns with TMC4: view

Protein tissue co-expression partners for TMC4 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for TMC4 Gene

Orthologs for TMC4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMC4 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia TMC4 35
  • 83.47 (n)
  • 83.57 (a)
TMC4 36
  • 80 (a)
(Mus musculus)
Mammalia Tmc4 35
  • 79.7 (n)
  • 76.74 (a)
Tmc4 16
Tmc4 36
  • 76 (a)
(Pan troglodytes)
Mammalia TMC4 35
  • 99.16 (n)
  • 99.02 (a)
TMC4 36
  • 99 (a)
(Bos Taurus)
Mammalia TMC4 36
  • 81 (a)
(Monodelphis domestica)
Mammalia TMC4 36
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia TMC4 36
  • 57 (a)
(Anolis carolinensis)
Reptilia TMC4 36
  • 41 (a)
(Danio rerio)
Actinopterygii tmc4 36
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
Species with no ortholog for TMC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMC4 Gene

Gene Tree for TMC4 (if available)
Gene Tree for TMC4 (if available)

Paralogs for TMC4 Gene

Paralogs for TMC4 Gene

(2) SIMAP similar genes for TMC4 Gene using alignment to 3 proteins: Pseudogenes for TMC4 Gene

genes like me logo Genes that share paralogs with TMC4: view

Variants for TMC4 Gene

Sequence variations from dbSNP and Humsavar for TMC4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_032621 -
VAR_032622 -
rs73062684 -- 54,170,611(+) TGTTT(A/G)TTTTA intron-variant
rs530369939 -- 54,172,202(+) CCCCC(A/G)GCTCC intron-variant
rs542178107 -- 54,170,334(+) CTGTC(-/A)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMC4 Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV Deletion 23290073
dgv4001n71 CNV Loss 21882294
nsv515623 CNV Loss 19592680
dgv4002n71 CNV Loss 21882294
nsv912398 CNV Loss 21882294
nsv510774 CNV Loss 20534489
nsv9751 CNV Gain 18304495
dgv1118e1 CNV Complex 17122850
nsv428371 CNV Gain+Loss 18775914
dgv1119e1 CNV Complex 17122850
esv2718857 CNV Deletion 23290073
esv1685576 CNV Deletion 17803354

Variation tolerance for TMC4 Gene

Residual Variation Intolerance Score: 32.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.76; 91.61% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TMC4 Gene

Disorders for TMC4 Gene

Relevant External Links for TMC4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMC4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMC4 Gene

Publications for TMC4 Gene

  1. Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis. (PMID: 12906855) Kurima K. … Griffith A.J. (Genomics 2003) 2 3 4 23 67
  2. TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins. (PMID: 12812529) Keresztes G. … Heller S. (BMC Genomics 2003) 2 3
  3. An atlas of genetic influences on human blood metabolites. (PMID: 24816252) Shin S.Y. … Soranzo N. (Nat. Genet. 2014) 3
  4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3
  5. Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions. (PMID: 17567994) Denoeud F. … Reymond A. (Genome Res. 2007) 3

Products for TMC4 Gene

Sources for TMC4 Gene