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Aliases for TMC3 Gene

Aliases for TMC3 Gene

  • Transmembrane Channel Like 3 2 3 5

External Ids for TMC3 Gene

Previous GeneCards Identifiers for TMC3 Gene

  • GC15M079192
  • GC15M079339
  • GC15M079410
  • GC15M081624
  • GC15M058383

Summaries for TMC3 Gene

GeneCards Summary for TMC3 Gene

TMC3 (Transmembrane Channel Like 3) is a Protein Coding gene. Diseases associated with TMC3 include epidermodysplasia verruciformis. An important paralog of this gene is TMC4.

UniProtKB/Swiss-Prot for TMC3 Gene

  • Probable ion channel.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMC3 Gene

Genomics for TMC3 Gene

Regulatory Elements for TMC3 Gene

Genomic Location for TMC3 Gene

81,331,217 bp from pter
81,374,213 bp from pter
42,997 bases
Minus strand

Genomic View for TMC3 Gene

Genes around TMC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMC3 Gene

Proteins for TMC3 Gene

  • Protein details for TMC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane channel-like protein 3
    Protein Accession:
    Secondary Accessions:
    • A2RTY2
    • B2RXJ3
    • Q7Z405

    Protein attributes for TMC3 Gene

    1100 amino acids
    Molecular mass:
    125685 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAP78778.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Due to an insert of 27 undefined residues.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMC3 Gene


neXtProt entry for TMC3 Gene

Proteomics data for TMC3 Gene at MOPED

Post-translational modifications for TMC3 Gene

  • Glycosylation at Asn 264
  • Modification sites at PhosphoSitePlus

Other Protein References for TMC3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMC3 Gene

Domains & Families for TMC3 Gene

Gene Families for TMC3 Gene

Protein Domains for TMC3 Gene


Suggested Antigen Peptide Sequences for TMC3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMC family.
  • Belongs to the TMC family.
genes like me logo Genes that share domains with TMC3: view

Function for TMC3 Gene

Molecular function for TMC3 Gene

UniProtKB/Swiss-Prot Function:
Probable ion channel.
genes like me logo Genes that share phenotypes with TMC3: view

Animal Model Products

miRNA for TMC3 Gene

miRTarBase miRNAs that target TMC3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMC3 Gene

Localization for TMC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMC3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMC3 Gene COMPARTMENTS Subcellular localization image for TMC3 gene
Compartment Confidence
cytosol 3
plasma membrane 3
cytoskeleton 2
golgi apparatus 1

No data available for Gene Ontology (GO) - Cellular Components for TMC3 Gene

Pathways & Interactions for TMC3 Gene

SuperPathways for TMC3 Gene

No Data Available

Interacting Proteins for TMC3 Gene

Gene Ontology (GO) - Biological Process for TMC3 Gene


No data available for Pathways by source and SIGNOR curated interactions for TMC3 Gene

Drugs & Compounds for TMC3 Gene

No Compound Related Data Available

Transcripts for TMC3 Gene

mRNA/cDNA for TMC3 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMC3 Gene

Transmembrane channel-like 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMC3 Gene

No ASD Table

Relevant External Links for TMC3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMC3 Gene

mRNA expression in normal human tissues for TMC3 Gene

SOURCE GeneReport for Unigene cluster for TMC3 Gene Hs.253489

genes like me logo Genes that share expression patterns with TMC3: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TMC3 Gene

Orthologs for TMC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMC3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMC3 35
  • 84.36 (n)
  • 82.81 (a)
TMC3 36
  • 83 (a)
(Canis familiaris)
Mammalia TMC3 35
  • 84.24 (n)
  • 81.69 (a)
TMC3 36
  • 82 (a)
(Mus musculus)
Mammalia Tmc3 35
  • 82.52 (n)
  • 81.55 (a)
Tmc3 16
Tmc3 36
  • 79 (a)
(Pan troglodytes)
Mammalia TMC3 35
  • 98.91 (n)
  • 98.55 (a)
TMC3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Tmc3 35
  • 82.58 (n)
  • 81.27 (a)
(Monodelphis domestica)
Mammalia TMC3 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia TMC3 36
  • 82 (a)
(Gallus gallus)
Aves TMC3 35
  • 70.1 (n)
  • 68.62 (a)
TMC3 36
  • 59 (a)
(Anolis carolinensis)
Reptilia TMC3 36
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmc3 35
  • 65.65 (n)
  • 66.27 (a)
(Danio rerio)
Actinopterygii TMC3 36
  • 54 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3280 36
  • 19 (a)
(Caenorhabditis elegans)
Secernentea tmc-1 36
  • 27 (a)
tmc-2 36
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
Species with no ortholog for TMC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMC3 Gene

Gene Tree for TMC3 (if available)
Gene Tree for TMC3 (if available)

Paralogs for TMC3 Gene

Paralogs for TMC3 Gene

(2) SIMAP similar genes for TMC3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TMC3: view

Variants for TMC3 Gene

Sequence variations from dbSNP and Humsavar for TMC3 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
VAR_066557 -
VAR_066558 -
VAR_066559 -
VAR_066560 -

Structural Variations from Database of Genomic Variants (DGV) for TMC3 Gene

Variant ID Type Subtype PubMed ID
nsv520339 CNV Loss 19592680

Variation tolerance for TMC3 Gene

Residual Variation Intolerance Score: 92.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.98; 84.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMC3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMC3 Gene

Disorders for TMC3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMC3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
epidermodysplasia verruciformis
  • lewandowsky-lutz syndrome
- elite association - COSMIC cancer census association via MalaCards
Search TMC3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TMC3

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TMC3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMC3 Gene

Publications for TMC3 Gene

  1. Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis. (PMID: 12906855) Kurima K. … Griffith A.J. (Genomics 2003) 2 3 4 23 67
  2. TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins. (PMID: 12812529) Keresztes G. … Heller S. (BMC Genomics 2003) 2 3
  3. Parkinson disease loci in the mid-western Amish. (PMID: 23793441) Davis M.F. … Haines J.L. (Hum. Genet. 2013) 3
  4. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody M.C. … Nusbaum C. (Nature 2006) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TMC3 Gene

Sources for TMC3 Gene

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