TMC3 Gene
protein-coding GIFtS: 41
GCID: GC15M081624
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transmembrane channel-like 3
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Aliases
for TMC3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Channel-Like 31 2 | | Transmembrane Channel-Like Protein 32 |
Export aliases for TMC3 gene to outside databasesPrevious GC identifers: GC15M079192 GC15M079339 GC15M079410 GC15M058383 |
Summaries
for TMC3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TMC3_HUMAN, Q7Z5M5Function: Probable ion channel (By similarity)
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Genomic Views
for TMC3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMC3 gene promoter:
COUP-TF1 COUP HNF-4alpha2 LCR-F1 YY1 HNF-4alpha1 HNF-1A Evi-1 COUP-TF HNF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMC3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMC3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q25.1 Ensembl cytogenetic band: 15q25.1 HGNC cytogenetic band: 15q24.3TMC3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15M081624: view genomic region
(about GC identifiers)
Start:
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81,623,558 bp from pter |
End:
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81,666,554 bp from pter |
Size:
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42,997 bases |
Orientation:
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minus strand |
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Proteins
for TMC3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TMC3_HUMAN, Q7Z5M5 (See
protein sequence)Recommended Name: Transmembrane channel-like protein 3 Size: 1100 amino acids; 125685 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=AAP78778.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Due to an insert of27 undefined residues;
Secondary accessions: A2RTY2 B2RXJ3 Q7Z405Alternative splicing: 2 isoforms: Q7Z5M5-1 Q7Z5M5-2 Explore the universe of human proteins at neXtProt for TMC3: NX_Q7Z5M5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q7Z5M5
TMC3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001074001.1
ENSEMBL proteins: ENSP00000452681 ENSP00000352413
Human Recombinant Protein Products for TMC3:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
TMC3 for ontologies About GeneDecksing
TMC3 Antibody Products:
Assay Products for TMC3: |
Protein
Domains /
Families
for TMC3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMC3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q7Z5M5ProtoNet protein and cluster: Q7Z5M5 1 Blocks protein family: IPB012496 TMC
UniProtKB/Swiss-Prot: TMC3_HUMAN, Q7Z5M5Similarity: Belongs to the TMC family |
Function
for TMC3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: TMC3_HUMAN, Q7Z5M5Function: Probable ion channel (By similarity)Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMC3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMC3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TMC3 (NM_001080532) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMC3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMC3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMC3 |
|
Pathways & Interactions
for TMC3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMC3
|
Drugs & Compounds
for TMC3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMC3
Search CenterWatch for drugs/clinical trials and news about TMC3
|
Transcripts
for TMC3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMC3 gene: NM_001080532.1 Unigene Cluster for TMC3: Transmembrane channel-like 3 Hs.253489 [show with all ESTs]Unigene Representative Sequence: AY2631633 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000558726(uc010blr.1) ENST00000359440(uc021ssj.1 uc021ssk.1)
ENST00000559982(uc002bgp.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMC3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMC3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TMC3 (NM_001080532) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMC3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMC3 |
Additional cDNA sequence: AY236490.1 AY263163.1 BC132679.1 BC143410.1 BC157874.1 2 DOTS entries: DT.100697389 DT.91858296 9 AceView cDNA sequences: AA490253 BQ878522 AY263163 AY236490 NM_181841 AI092720 AI088153 AI272324 BX640632
GeneLoc Exon Structure
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Expression
for TMC3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMC3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTTCCCAGG
About this image
See TMC3 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.253489
SABiosciences Custom PCR Arrays for TMC3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMC3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMC3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMC3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMC3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMC3 |
Orthologs
for TMC3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TMC3 gene from 5/17 species (see all 17) About this table
ENSEMBL Gene Tree for TMC3 (if available)
TreeFam Gene Tree for TMC3 (if available) |
Paralogs
for TMC3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TMC3 gene
- TMC72 TMC22 TMC82 TMC52 TMC62 TMC12 TMC42
2 SIMAP similar genes for TMC3 using alignment to 2 protein entries: TMC3_HUMAN (see all proteins):TMC1 TMC2
TMC3 for paralogs About GeneDecksing
|
Genomic Variants
for TMC3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMC3 (81623558 - 81666554 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for TMC3
2 CNVs: 49597 49596 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMC3 |
|
Disorders
/ Diseases
for TMC3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TMC3 for disorders About GeneDecksing
2  diseases for TMC3: About MalaCardsepidermodysplasia verruciformis hearing loss
1 disease from the University of Copenhagen DISEASES database for TMC3:Epidermodysplasia verruciformis Export disorders for TMC3 gene to outside databases
|
Publications
for TMC3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMC3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMC3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis. (PubMed id 12906855)1, 2, 3, 9 Kurima K.... Griffith A.J. (2003)
- TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins. (PubMed id 12812529)1, 2, 3 Keresztes G.... Heller S. (2003)
- Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)1, 2 Zody M.C....Nusbaum C. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for TMC3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing TMC3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMC3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMC3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMC3 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for TMC3 gene:
Search GeneIP for patents involving TMC3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMC3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TMC3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMC3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMC3 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMC3 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMC3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMC3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TMC3 | | OriGene Custom Protein Services for TMC3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMC3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMC3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMC3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMC3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMC3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMC3 |
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 |  |  |  | |
| | | | Search Tocris compounds for TMC3 |
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 | | | TMC3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMC3 |
|  |  |  |  | | | | ThermoFisher Antibodies for TMC3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMC3 |
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