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Aliases for TMC3 Gene

Aliases for TMC3 Gene

  • Transmembrane Channel Like 3 2 3 5

External Ids for TMC3 Gene

Previous GeneCards Identifiers for TMC3 Gene

  • GC15M079192
  • GC15M079339
  • GC15M079410
  • GC15M081624
  • GC15M058383

Summaries for TMC3 Gene

GeneCards Summary for TMC3 Gene

TMC3 (Transmembrane Channel Like 3) is a Protein Coding gene. Diseases associated with TMC3 include Epidermodysplasia Verruciformis and Deafness, Autosomal Recessive 48. An important paralog of this gene is TMC2.

UniProtKB/Swiss-Prot for TMC3 Gene

  • Probable ion channel.

Additional gene information for TMC3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMC3 Gene

Genomics for TMC3 Gene

Regulatory Elements for TMC3 Gene

Enhancers for TMC3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15H081337 1.4 Ensembl ENCODE dbSUPER 19.4 +35.9 35915 2 PKNOX1 INSM2 FEZF1 ZNF366 SCRT2 FOS ZNF362 YY2 USF2 CEBPB TMC3 TMC3-AS1 STARD5 ENSG00000273920
GH15H081310 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.9 +60.6 60638 6 PKNOX1 NFIB SIN3A FOS IKZF2 SMARCA5 CEBPB MTA1 IKZF1 STAT3 TLNRD1 TMC3 ENSG00000271725 STARD5 IL16 PIR43838 GC15P081312
GH15H081291 1.6 FANTOM5 ENCODE dbSUPER 10.8 +75.8 75832 14 HDGF FOXA2 PKNOX1 SIN3A YY1 ZNF143 ZNF207 FOS ATF7 RUNX3 TLNRD1 STARD5 IL16 TMC3 ENSG00000271725 PIR47037 PIR53519
GH15H081284 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.9 +87.4 87357 5 HDGF ZNF687 POLR2A REST RUNX3 NR2F2 TLNRD1 STARD5 TMC3 ENSG00000271725 IL16 PIR39910 GC15P081268
GH15H081266 1.1 Ensembl ENCODE 10.8 +108.0 108039 1 HDAC1 TBP ATF1 RB1 ARNT KLF17 DMAP1 ZNF2 RAD21 RFX5 MESD TMC3 IL16 GC15P081268 GC15M081220
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMC3 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMC3 Gene

81,331,217 bp from pter
81,374,213 bp from pter
42,997 bases
Minus strand

Genomic View for TMC3 Gene

Genes around TMC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMC3 Gene

Proteins for TMC3 Gene

  • Protein details for TMC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane channel-like protein 3
    Protein Accession:
    Secondary Accessions:
    • A2RTY2
    • B2RXJ3
    • Q7Z405

    Protein attributes for TMC3 Gene

    1100 amino acids
    Molecular mass:
    125685 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAP78778.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Due to an insert of 27 undefined residues.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMC3 Gene


neXtProt entry for TMC3 Gene

Post-translational modifications for TMC3 Gene

  • Glycosylation at posLast=264264
  • Modification sites at PhosphoSitePlus

Other Protein References for TMC3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMC3 Gene

Domains & Families for TMC3 Gene

Gene Families for TMC3 Gene

Protein Domains for TMC3 Gene


Suggested Antigen Peptide Sequences for TMC3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMC family.
  • Belongs to the TMC family.
genes like me logo Genes that share domains with TMC3: view

Function for TMC3 Gene

Molecular function for TMC3 Gene

UniProtKB/Swiss-Prot Function:
Probable ion channel.

Phenotypes From GWAS Catalog for TMC3 Gene

genes like me logo Genes that share phenotypes with TMC3: view

Animal Model Products

CRISPR Products

miRNA for TMC3 Gene

miRTarBase miRNAs that target TMC3

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMC3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMC3 Gene

Localization for TMC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMC3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMC3 gene
Compartment Confidence
plasma membrane 3
cytosol 3
cytoskeleton 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TMC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMC3: view

Pathways & Interactions for TMC3 Gene

No Data Available

Interacting Proteins for TMC3 Gene

Gene Ontology (GO) - Biological Process for TMC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
genes like me logo Genes that share ontologies with TMC3: view

No data available for Pathways by source and SIGNOR curated interactions for TMC3 Gene

Drugs & Compounds for TMC3 Gene

No Compound Related Data Available

Transcripts for TMC3 Gene

mRNA/cDNA for TMC3 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMC3 Gene

Transmembrane channel-like 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMC3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TMC3 Gene

No ASD Table

Relevant External Links for TMC3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMC3 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMC3 Gene:


SOURCE GeneReport for Unigene cluster for TMC3 Gene:


Evidence on tissue expression from TISSUES for TMC3 Gene

  • Heart(4)
  • Lung(4)
genes like me logo Genes that share expression patterns with TMC3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMC3 Gene

Orthologs for TMC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMC3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMC3 33 34
  • 98.91 (n)
(Bos Taurus)
Mammalia TMC3 33 34
  • 84.36 (n)
(Canis familiaris)
Mammalia TMC3 33 34
  • 84.24 (n)
(Rattus norvegicus)
Mammalia Tmc3 33
  • 82.58 (n)
(Mus musculus)
Mammalia Tmc3 33 16 34
  • 82.52 (n)
(Ornithorhynchus anatinus)
Mammalia TMC3 34
  • 82 (a)
(Monodelphis domestica)
Mammalia TMC3 34
  • 70 (a)
(Gallus gallus)
Aves TMC3 33 34
  • 70.1 (n)
(Anolis carolinensis)
Reptilia TMC3 34
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmc3 33
  • 65.65 (n)
(Danio rerio)
Actinopterygii TMC3 34
  • 54 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3280 34
  • 19 (a)
(Caenorhabditis elegans)
Secernentea tmc-2 34
  • 28 (a)
tmc-1 34
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 53 (a)
Species where no ortholog for TMC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMC3 Gene

Gene Tree for TMC3 (if available)
Gene Tree for TMC3 (if available)

Paralogs for TMC3 Gene

Paralogs for TMC3 Gene

(2) SIMAP similar genes for TMC3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TMC3: view

Variants for TMC3 Gene

Sequence variations from dbSNP and Humsavar for TMC3 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs150843673 Benign 81,332,588(+) CTGCC(A/G/T)ACACG intron-variant, reference, stop-gained
rs1000003947 -- 81,341,124(+) CATTT(A/G)CGATT intron-variant
rs1000085876 -- 81,351,166(+) TTTGA(A/C)TCAAA intron-variant
rs1000174733 -- 81,335,546(+) TGTAG(A/G)CTTCT intron-variant
rs1000177469 -- 81,338,216(+) TTTGC(A/G)GTCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMC3 Gene

Variant ID Type Subtype PubMed ID
nsv1048106 CNV gain 25217958
nsv1048788 CNV loss 25217958
nsv1054305 CNV gain 25217958
nsv1108970 CNV deletion 24896259
nsv520339 CNV loss 19592680

Variation tolerance for TMC3 Gene

Residual Variation Intolerance Score: 92.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.98; 84.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMC3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMC3 Gene

Disorders for TMC3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TMC3 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
epidermodysplasia verruciformis
  • lewandowsky-lutz syndrome
deafness, autosomal recessive 48
  • autosomal recessive nonsyndromic deafness 48
- elite association - COSMIC cancer census association via MalaCards
Search TMC3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TMC3

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TMC3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMC3 Gene

Publications for TMC3 Gene

  1. Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis. (PMID: 12906855) Kurima K … Griffith AJ (Genomics 2003) 2 3 4 22 60
  2. TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins. (PMID: 12812529) Keresztes G … Heller S (BMC genomics 2003) 2 3 4 60
  3. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody MC … Nusbaum C (Nature 2006) 3 4 60
  4. Conductance and block of hair-cell mechanotransducer channels in transmembrane channel-like protein mutants. (PMID: 24981230) Beurg M … Fettiplace R (The Journal of general physiology 2014) 3 60
  5. Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function. (PMID: 24983941) Tang W … Cassano PA (PloS one 2014) 3 60

Products for TMC3 Gene

Sources for TMC3 Gene

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