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Aliases for TMC2 Gene

Aliases for TMC2 Gene

  • Transmembrane Channel-Like 2 2 3
  • Transmembrane Cochlear-Expressed Protein 2 3 4
  • Transmembrane, Cochlear Expressed, 2 2 3
  • C20orf145 3 4
  • Transmembrane Channel-Like Protein 2 3
  • DJ686C3.3 3

External Ids for TMC2 Gene

Previous HGNC Symbols for TMC2 Gene

  • C20orf145

Previous GeneCards Identifiers for TMC2 Gene

  • GC20P002505
  • GC20P002512
  • GC20P002465

Summaries for TMC2 Gene

Entrez Gene Summary for TMC2 Gene

  • This gene is considered a member of a gene family predicted to encode transmembrane proteins. The specific function of this gene is unknown; however, expression in the inner ear suggests that it may be crucial for normal auditory function. Mutations in this gene may underlie hereditary disorders of balance and hearing. [provided by RefSeq, Jul 2008]

GeneCards Summary for TMC2 Gene

TMC2 (Transmembrane Channel-Like 2) is a Protein Coding gene. An important paralog of this gene is TMC7.

UniProtKB/Swiss-Prot for TMC2 Gene

  • Probable ion channel required for the normal function of cochlear hair cells.

Gene Wiki entry for TMC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMC2 Gene

Genomics for TMC2 Gene

Regulatory Elements for TMC2 Gene

Genomic Location for TMC2 Gene

Start:
2,536,607 bp from pter
End:
2,641,848 bp from pter
Size:
105,242 bases
Orientation:
Plus strand

Genomic View for TMC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMC2 Gene

Proteins for TMC2 Gene

  • Protein details for TMC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDI7-TMC2_HUMAN
    Recommended name:
    Transmembrane channel-like protein 2
    Protein Accession:
    Q8TDI7
    Secondary Accessions:
    • Q5JXT0
    • Q5JXT1
    • Q6UWW4
    • Q6ZS41
    • Q8N9F3
    • Q9BYN2
    • Q9BYN3
    • Q9BYN4
    • Q9BYN5

    Protein attributes for TMC2 Gene

    Size:
    906 amino acids
    Molecular mass:
    102610 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ88976.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC04423.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMC2 Gene

Proteomics data for TMC2 Gene at MOPED

Post-translational modifications for TMC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMC2 Gene

Domains for TMC2 Gene

Protein Domains for TMC2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TMC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TDI7

UniProtKB/Swiss-Prot:

TMC2_HUMAN :
  • Q8TDI7
Family:
  • Belongs to the TMC family.
genes like me logo Genes that share domains with TMC2: view

No data available for Gene Families for TMC2 Gene

Function for TMC2 Gene

Molecular function for TMC2 Gene

UniProtKB/Swiss-Prot Function: Probable ion channel required for the normal function of cochlear hair cells.

Gene Ontology (GO) - Molecular Function for TMC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005245 voltage-gated calcium channel activity IEA --
genes like me logo Genes that share ontologies with TMC2: view
genes like me logo Genes that share phenotypes with TMC2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMC2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TMC2 Gene

Localization for TMC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMC2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMC2 Gene COMPARTMENTS Subcellular localization image for TMC2 gene
Compartment Confidence
plasma membrane 3
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for TMC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0032426 stereocilium bundle tip IEA --
genes like me logo Genes that share ontologies with TMC2: view

Pathways for TMC2 Gene

SuperPathways for TMC2 Gene

No Data Available

Interacting Proteins for TMC2 Gene

Gene Ontology (GO) - Biological Process for TMC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050910 detection of mechanical stimulus involved in sensory perception of sound IEA --
GO:0060005 vestibular reflex IEA --
GO:0070588 calcium ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with TMC2: view

No data available for Pathways by source for TMC2 Gene

Transcripts for TMC2 Gene

mRNA/cDNA for TMC2 Gene

(5) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(3) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMC2 Gene

Transmembrane channel-like 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMC2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TMC2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMC2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20
SP1: - - -
SP2:
SP3:

Relevant External Links for TMC2 Gene

GeneLoc Exon Structure for
TMC2
ECgene alternative splicing isoforms for
TMC2

Expression for TMC2 Gene

mRNA expression in normal human tissues for TMC2 Gene

mRNA differential expression in normal tissues according to GTEx for TMC2 Gene

This gene is overexpressed in Brain - Cerebellum (16.0), Brain - Cerebellar Hemisphere (15.1), and Pituitary (6.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TMC2 Gene

SOURCE GeneReport for Unigene cluster for TMC2 Gene Hs.352626

mRNA Expression by UniProt/SwissProt for TMC2 Gene

Q8TDI7-TMC2_HUMAN
Tissue specificity: Detected in fetal cochlea
genes like me logo Genes that share expressions with TMC2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TMC2 Gene

Orthologs for TMC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMC2 35
  • 99.04 (n)
  • 98.78 (a)
TMC2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMC2 35
  • 89.11 (n)
  • 87.71 (a)
TMC2 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMC2 35
  • 89.51 (n)
  • 88.56 (a)
TMC2 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmc2 35
  • 84.46 (n)
  • 83.52 (a)
Tmc2 16
Tmc2 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMC2 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMC2 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmc2 35
  • 84.44 (n)
  • 83.07 (a)
chicken
(Gallus gallus)
Aves TMC2 35
  • 71.43 (n)
  • 73.24 (a)
TMC2 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMC2 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490320 35
  • 65.39 (n)
  • 68.02 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-267i17.6 35
  • 62.51 (n)
  • 61.66 (a)
TMC2 (1 of 2) 36
  • 58 (a)
OneToMany
TMC2 (2 of 2) 36
  • 65 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG3280 36
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tmc-1 36
  • 22 (a)
ManyToMany
tmc-2 36
  • 22 (a)
ManyToMany
T13G4.3 37
  • 37 (a)
B0416.1 37
  • 34 (a)
Species with no ortholog for TMC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMC2 Gene

ENSEMBL:
Gene Tree for TMC2 (if available)
TreeFam:
Gene Tree for TMC2 (if available)

Paralogs for TMC2 Gene

Paralogs for TMC2 Gene

Selected SIMAP similar genes for TMC2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMC2: view

Variants for TMC2 Gene

Sequence variations from dbSNP and Humsavar for TMC2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs721059 -- 2,544,281(-) atgct(A/G)ctgca intron-variant
rs726075 -- 2,634,091(-) TCAAA(C/G)CATAA intron-variant
rs728499 -- 2,620,113(-) cTGTT(C/T)TTTTC intron-variant
rs730297 -- 2,627,279(-) AAAGA(C/T)GGAAG intron-variant
rs742838 -- 2,565,635(-) ATGCC(A/G)TCTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMC2 Gene

Variant ID Type Subtype PubMed ID
nsv470535 CNV Gain 18288195
esv28094 CNV Gain 19812545
esv32983 CNV Gain 17666407

Relevant External Links for TMC2 Gene

HapMap Linkage Disequilibrium report
TMC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMC2 Gene

Disorders for TMC2 Gene

(1) University of Copenhagen DISEASES for TMC2 Gene

Relevant External Links for TMC2

Genetic Association Database (GAD)
TMC2
genes like me logo Genes that share disorders with TMC2: view

No data available for UniProtKB/Swiss-Prot for TMC2 Gene

Publications for TMC2 Gene

  1. Dominant and recessive deafness caused by mutations of a novel gene, TMC1, required for cochlear hair-cell function. (PMID: 11850618) Kurima K. … Griffith A.J. (Nat. Genet. 2002) 2 3 4 23
  2. Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis. (PMID: 12906855) Kurima K. … Griffith A.J. (Genomics 2003) 2 3 23
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for TMC2 Gene

Sources for TMC2 Gene

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