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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMC1 Gene

protein-coding   GIFtS: 53
GCID: GC09P075137

Transmembrane Channel-Like 1

(Previous names: transmembrane, cochlear expressed, 1)
(Previous symbols: DFNA36, DFNB7, DFNB11)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transmembrane Channel-Like 11 2     Transmembrane, Cochlear Expressed, 11 2
DFNA361 2 5     Transmembrane Cochlear-Expressed Protein 12 3
DFNB111 2 5     Transmembrane Channel-Like Protein 12
DFNB71 2 5     

External Ids:    HGNC: 165131   Entrez Gene: 1175312   Ensembl: ENSG000001650917   OMIM: 6067065   UniProtKB: Q8TDI83   

Export aliases for TMC1 gene to outside databases

Previous GC identifers: GC09P066275 GC09P067087 GC09P068801 GC09P070688 GC09P070593 GC09P072366 GC09P074326 GC09P074211 GC09P044959


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TMC1 Gene:
This gene is considered a member of a gene family predicted to encode transmembrane proteins. The specific
function of this gene is unknown; however, it is known to be required for normal function of cochlear hair cells.
Mutations in this gene have been associated with progressive postlingual hearing loss and profound prelingual
deafness. (provided by RefSeq, Jul 2008)

GeneCards Summary for TMC1 Gene: 
TMC1 (transmembrane channel-like 1) is a protein-coding gene. Diseases associated with TMC1 include deafness, autosomal recessive 7, and dfnb 7/11 nonsyndromic hearing loss and deafness. An important paralog of this gene is TMC7.

UniProtKB/Swiss-Prot: TMC1_HUMAN, Q8TDI8
Function: Probable ion channel required for the normal function of cochlear hair cells (By similarity)

Gene Wiki entry for TMC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMC1 gene promoter:
         Sox5   AP-1   CUTL1   POU6F1 (c2)   Cdc5   E47   Gfi-1   Hand1   Hlf   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMC1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMC1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q21.12   Ensembl cytogenetic band:  9q21.13   HGNC cytogenetic band: 9q21

TMC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMC1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P075137:  view genomic region     (about GC identifiers)

Start:
75,136,717 bp from pter      End:
75,451,267 bp from pter
Size:
314,551 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TMC1_HUMAN, Q8TDI8 (See protein sequence)
Recommended Name: Transmembrane channel-like protein 1  
Size: 760 amino acids; 87768 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=BAC05351.1; Type=Erroneous termination; Positions=744; Note=Translated as Arg;
Sequence=BAC05351.1; Type=Frameshift; Positions=588;
Secondary accessions: A8MVZ2 B1AM91

Explore the universe of human proteins at neXtProt for TMC1: NX_Q8TDI8

Explore proteomics data for TMC1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TDI8

  • TMC1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TMC1 Protein Expression
    REFSEQ proteins: NP_619636.2  
    ENSEMBL proteins: 
     ENSP00000297784   ENSP00000341433   ENSP00000379538  

    Human Recombinant Protein Products for TMC1: 
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    Cloud-Clone Corp. Proteins for TMC1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009897external side of plasma membrane IEA--
    GO:0016021integral to membrane IEA--
    GO:0032426stereocilium bundle tip IEA--

    TMC1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR012496 TMC

    Graphical View of Domain Structure for InterPro Entry Q8TDI8

    ProtoNet protein and cluster: Q8TDI8

    1 Blocks protein domain: IPB012496 TMC

    UniProtKB/Swiss-Prot: TMC1_HUMAN, Q8TDI8
    Similarity: Belongs to the TMC family


    TMC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TMC1_HUMAN, Q8TDI8
    Function: Probable ion channel required for the normal function of cochlear hair cells (By similarity)

    Phenotypes:
         2 GenomeRNAi human phenotypes for TMC1:

     Increased gamma-H2AX phosphory  Increased number of cells in m 

         5 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Tmc1):
     behavior/neurological  hearing/vestibular/ear  integument  nervous system  vision/eye 

    TMC1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TMC1 
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate TMC1:
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    SwitchGear 3'UTR luciferase reporter plasmidTMC1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMC1

    5 Interacting proteins for TMC1 (Q8TDI83) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GABARAPL2P605203I2D: score=1 
    MAP1LC3BQ9GZQ83I2D: score=1 
    NSMAFQ926363I2D: score=1 
    PRKAA1Q131313I2D: score=1 
    --Q6FG913I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport IEA--
    GO:0050910detection of mechanical stimulus involved in sensory perception of sound IEA--
    GO:0060005vestibular reflex IEA--
    GO:0060117auditory receptor cell development IEA--

    TMC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMC1

    Search CenterWatch for drugs/clinical trials and news about TMC1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TMC1 gene: 
    NM_138691.2  

    Unigene Cluster for TMC1:

    Transmembrane channel-like 1
    Hs.670211  [show with all ESTs]
    Unigene Representative Sequence: AF417578
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000297784(uc010moz.1 uc004aiz.1) ENST00000497073 ENST00000492418
    ENST00000486417 ENST00000469455 ENST00000340019(uc004aja.1 uc004ajb.1 uc004ajc.1 uc010mpa.1)
    ENST00000396237
    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate TMC1:
    hsa-miR-3163 hsa-miR-1287
    SwitchGear 3'UTR luciferase reporter plasmidTMC1 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMC1

    Additional mRNA sequence: 

    AF417578.1 AK098607.1 AK307461.1 BC103955.1 BC103956.1 BC114380.1 BC114449.1 BC141860.1 

    3 DOTS entries:

    DT.97764636  DT.100013271  DT.75136370 

    11 AceView cDNA sequences:

    NM_138691 BP370498 AF417578 BX093725 AI699911 AI686465 AW295808 AK098607 
    BG150313 AI336832 BF214797 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGCCAATT
    TMC1 Expression
    About this image


    See TMC1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMC1

    SOURCE GeneReport for Unigene cluster: Hs.670211

    UniProtKB/Swiss-Prot: TMC1_HUMAN, Q8TDI8
    Tissue specificity: Detected in fetal cochlea, and at low levels in placenta and testis

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TMC1 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmc11 , 5 transmembrane channel-like gene family 11, 5 88.7(n)1
    96.81(a)1
      19 (13.98 cM)5
    134091  NM_028953.21  NP_083229.11 
     207834585 
    chicken
    (Gallus gallus)
    Aves TMC11 transmembrane channel-like 1 70.42(n)
    68.06(a)
      427255  NM_001006580.1  NP_001006580.1 
    lizard
    (Anolis carolinensis)
    Reptilia TMC16
    Uncharacterized protein
    65(a)
    1 ↔ 1
    2(47993071-48060703)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5672371 novel protein similar to vertebrate transmembrane channel more 64.56(n)
    63.6(a)
      567237  XM_690529.3  XP_695621.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG32806
    --
    13(a)
    1 → many
    3L(9596701-9607009)
    worm
    (Caenorhabditis elegans)
    Secernentea T13G4.33   -- 34(a)
    (best of 2)
      X(1202384-1212051)   --


    ENSEMBL Gene Tree for TMC1 (if available)
    TreeFam Gene Tree for TMC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TMC1 gene
    TMC72  TMC32  TMC22  TMC82  TMC52  TMC42  TMC62  
    2 SIMAP similar genes for TMC1 using alignment to 5 protein entries:     TMC1_HUMAN (see all proteins):
    TMC2    TMC3

    TMC1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/6163 SNPs in TMC1 are shown (see all 6163)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0141254
    Deafness, autosomal dominant, 36 (DFNA36)4--see VAR_0141252 D N mis40--------
    VAR_0141264
    Deafness, autosomal recessive, 7 (DFNB7)4--see VAR_0141262 M V mis40--------
    rs25896151,2
    C,F,A,Hnon-pathogenic175187803(-) GTCTCA/GTCTTC 2 D syn1 ese335Minor allele frequency- G:0.48NA NS EA WA CSA EU 8676
    rs17969931,2,4
    C,F,A,Hnon-pathogenic175199588(-) TTCTTC/TTTCTC 2 K E mis1 trp323Minor allele frequency- T:0.23NA NS EA WA EU 7989
    rs170581531,2,4
    C,F,Hnon-pathogenic175291311(+) CAATAT/CGATCA 2 /T /M mis118Minor allele frequency- C:0.02NA NS EA EU 7501
    rs345324211,2
    C,Fnon-pathogenic175315232(+) GAATTC/TGACAT 2 F syn14Minor allele frequency- T:0.10NA EU 6066
    rs1219080731,2
    C,Fpathogenic175193644(+) TACCTC/TGAAGA 2 R * stg10--------
    rs1219080721,2
    Cpathogenic175315233(+) AATTCA/C/GACATC 3 N H D mis10--------
    rs1110334971,2
    Cprobable-non-pathogenic175271499(+) ATTCCA/GTTCTC 2 I V mis10--------
    rs1110334641,2
    Cprobable-non-pathogenic175287541(+) CACAAC/TGAACT 2 T M mis10--------

    HapMap Linkage Disequilibrium report for TMC1 (75136717 - 75386717 bp, first 250kb of TMC1)

    Structural Variations
         Database of Genomic Variants (DGV) 10/18 variations for TMC1 (see all 18):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2738550CNV Deletion23290073
    esv1000190CNV Insertion20482838
    esv273677CNV Insertion20981092
    esv273406CNV Insertion20981092
    esv270202CNV Insertion20981092
    esv271909CNV Insertion20981092
    nsv416490CNV Insertion16902084
    esv2652527CNV Insertion19546169
    esv268860CNV Insertion20981092
    esv272215CNV Insertion20981092


    Human Gene Mutation Database (HGMD): TMC1

    Locus Specific Mutation Databases (LSDB): TMC1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TMC1
    DNA2.0 Custom Variant and Variant Library Synthesis for TMC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606706   
    OMIM disorders: 600974  606705  
    UniProtKB/Swiss-Prot: TMC1_HUMAN, Q8TDI8
  • Deafness, autosomal dominant, 36 (DFNA36) [MIM:606705]: A form of non-syndromic sensorineural hearing
    loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to
    the brain, or the area of the brain that receives sound information. DFNA36 is a bilateral hearing loss, and
    begins at 5-10 years of age. It progresses to profound deafness within 10-15 years. Note=The disease is caused by
    mutations affecting the gene represented in this entry
  • Deafness, autosomal recessive, 7 (DFNB7) [MIM:600974]: A form of non-syndromic sensorineural hearing
    loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to
    the brain, or the area of the brain that receives sound information. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 12 diseases for TMC1:    About MalaCards
    deafness, autosomal recessive 7    dfnb 7/11 nonsyndromic hearing loss and deafness    deafness, autosomal dominant 36    dfna36 nonsyndromic hearing loss and deafness
    toxic megacolon    megacolon    enlarged vestibular aqueduct    nonsyndromic hearing loss and deafness, autosomal dominant
    epidermodysplasia verruciformis    nonsyndromic hearing loss and deafness, autosomal recessive    sensorineural hearing loss    nonsyndromic deafness

    4 diseases from the University of Copenhagen DISEASES database for TMC1:
    Nonsyndromic deafness     Sensorineural hearing loss     Hodgkin's lymphoma, nodular sclerosis     Toxic megacolon

    TMC1 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for TMC1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dfna36 99.3 16 17250663 (4), 18616530 (2), 15354000 (1), 19180119 (1) (see all 8)
    dfnb7 98.7 17 17877751 (4), 15605408 (2), 16287143 (2), 18616530 (2) (see all 6)
    hearing loss sensorineural 63.9 2 19187973 (2)

    Genetic Association Database (GAD): TMC1
    Human Genome Epidemiology (HuGE) Navigator: TMC1 (3 documents)

    Export disorders for TMC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMC1 gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with TMC1)
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    1. Dominant and recessive deafness caused by mutations of a novel gene, TMC1, required for cochlear hair-cell function. (PubMed id 11850618)1, 2, 3, 9 Kurima K.... Griffith A.J. (2002)
    2. Novel TMC1 structural and splice variants associated with congenital nonsyndromic deafness in a Sudanese pedigree. (PubMed id 15605408)1, 4, 9 Meyer C.G....Horstmann R.D. (2005)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Beethoven, a mouse model for dominant, progressive hearing loss DFNA36. (PubMed id 11850623)1, 3 Vreugde S....Steel K.P. (2002)
    6. Mutation analysis of TMC1 identifies four new mutations and suggests an additional deafness gene at loci DFNA36 and DFNB7/11. (PubMed id 18616530)1, 9 Hilgert N....Van Camp G. (2008)
    7. Identities, frequencies and origins of TMC1 mutations causing DFNB7/B11 deafness in Pakistan. (PubMed id 17877751)1, 9 Kitajiri S.I....Griffith A.J. (2007)
    8. Four novel TMC1 (DFNB7/DFNB11) mutations in Turkish patients with congenital autosomal recessive nonsyndromic hearing loss. (PubMed id 16287143)1, 9 Kalay E....Kremer H. (2005)
    9. Mutations in TMC1 contribute significantly to nonsyndromic autosomal recessive sensorineural hearing loss: a report of five novel mutations. (PubMed id 19187973)1, 9 Sirmaci A....Tekin M. (2009)
    10. Amino acid 572 in TMC1: hot spot or critical functional residue for dominant mutations causing hearing impairment. (PubMed id 19180119)1, 9 Hilgert N....Van Camp G. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 117531 HGNC: 16513 AceView: TMC1 Ensembl:ENSG00000165091 euGenes: HUgn117531
    ECgene: TMC1 H-InvDB: TMC1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TMC1 gene:
    Search GeneIP for patents involving TMC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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