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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMBIM6 Gene

protein-coding   GIFtS: 49
GCID: GC12P050101

transmembrane BAX inhibitor motif containing 6

(Previous name: testis enhanced gene transcript )
(Previous symbol: TEGT)
 Explore 14 diseases affiliated with
TMBIM6 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TMBIM6    

Aliases
for TMBIM6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Transmembrane BAX Inhibitor Motif Containing 61 2     Testis-Enhanced Gene Transcript Protein2 3
TEGT1 2 3 5     Transmembrane BAX Inhibitor Motif-Containing Protein 62 3
BI-11 2 3     Bax Inhibitor 12
BAXI11 2     BI13
Testis Enhanced Gene Transcript1 2     

External Ids:    HGNC: 117231   Entrez Gene: 70092   Ensembl: ENSG000001396447   OMIM: 6007485   UniProtKB: P550613   

Export aliases for TMBIM6 gene to outside databases

Previous GC identifers: GC12P048422 GC12P050135 GC12P047166


Summaries
for TMBIM6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: BI1_HUMAN, P55061
Function: Suppressor of apoptosis. Modulates unfolded protein response signaling. Modulate ER calcium homeostasis by
acting as a calcium-leak channel

Gene Wiki entry for TMBIM6 (TEGT)


Genomic Views
for TMBIM6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMBIM6 gene promoter:
         HOXA9   CHOP-10   FOXD1   ATF6   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 10): TMBIM6 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMBIM6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMBIM6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q12-q13   Ensembl cytogenetic band:  12q13.12   HGNC cytogenetic band: 12q12-q13

TMBIM6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMBIM6 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P050101:  view genomic region     (about GC identifiers)

Start:
 50,101,508 bp from pter      End:
 50,158,717 bp from pter
Size:
 57,210 bases      Orientation:
 plus strand

Proteins
for TMBIM6 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: BI1_HUMAN, P55061 (See protein sequence)
Recommended Name: Bax inhibitor 1  
Size: 237 amino acids; 26538 Da
Subunit: Interacts with BCL2 and BCL2L1/BCLX
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Sequence caution: Sequence=AAH36203.2; Type=Erroneous initiation;
Secondary accessions: B2R5M4 O14938 Q643A7 Q96J50

Explore the universe of human proteins at neXtProt for TMBIM6: NX_P55061

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P55061

    • TMBIM6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001092046.1  NP_003208.2  

    ENSEMBL proteins: 
     ENSP00000449000   ENSP00000450417   ENSP00000450159   ENSP00000446668   ENSP00000448269  
     ENSP00000447400   ENSP00000447074   ENSP00000448612   ENSP00000450050   ENSP00000446734  
     ENSP00000267115   ENSP00000449904   ENSP00000449421   ENSP00000448036   ENSP00000447888  
     ENSP00000450265   ENSP00000449907   ENSP00000450305   ENSP00000450158   ENSP00000378454  
     ENSP00000447030   ENSP00000389277   ENSP00000445903   ENSP00000440808  

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    Novus Biologicals TMBIM6 Protein
    Novus Biologicals TMBIM6 Lysates
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    Uscn Proteins for TMBIM6

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005626insoluble fraction ----
    GO:0005634nucleus TAS8530040
    GO:0005783endoplasmic reticulum TAS10087504
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005887integral to plasma membrane TAS10087504


    TMBIM6 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for TMBIM6 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TMBIM6 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR006214 Bax_inhibitor_1-related
     IPR006213 Bax_inhbtr1_CS

    Graphical View of Domain Structure for InterPro Entry P55061

    ProtoNet protein and cluster: P55061

    1 Blocks protein family: IPB006213 Bax inhibitor 1

    UniProtKB/Swiss-Prot: BI1_HUMAN, P55061
    Domain: The intra-membrane loop at the C-terminus acts as a calcium pore, mediating calcium leak from the ER into the
    cytosol
    Similarity: Belongs to the BI1 family


    Function
    for TMBIM6 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: BI1_HUMAN, P55061
    Function: Suppressor of apoptosis. Modulates unfolded protein response signaling. Modulate ER calcium homeostasis by
    acting as a calcium-leak channel

    miRNA
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    hsa-miR-1914* hsa-miR-106a hsa-miR-128 hsa-miR-1258 hsa-miR-519a hsa-miR-208b hsa-miR-93 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmid: TMBIM6 3' UTR sequence
    Inhib. RNA
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    Clone
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    Animal Models:
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Tmbim6):
     homeostasis/metabolism  nervous system 

    TMBIM6 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TMBIM6 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TMBIM6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/15 Interacting proteins for TMBIM6 (P550613 ENSP000003892774) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BCL2P104153, ENSP000003296234I2D: score=4 STRING: ENSP00000329623
    BADQ929343, ENSP000003091034I2D: score=1 STRING: ENSP00000309103
    BCL2L1Q078173, ENSP000003025644I2D: score=2 STRING: ENSP00000302564
    C1orf123Q9NWV43I2D: score=3 
    STAT6P422263I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0006986response to unfolded protein IEA--
    GO:0043066negative regulation of apoptotic process IEA--


    TMBIM6 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TMBIM6 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TMBIM6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMBIM6
    1 Novoseek chemical compound relationship for TMBIM6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 0 2 20193962 (2)

    Search CenterWatch for drugs/clinical trials and news about TMBIM6 / BI1 

    Transcripts
    for TMBIM6 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TMBIM6 gene (2 alternative transcripts): 
    NM_001098576.1  NM_003217.2  

    Unigene Cluster for TMBIM6:

    Transmembrane BAX inhibitor motif containing 6
    Hs.743965  [show with all ESTs]
    Unigene Representative Sequence: NM_001098576
    18/30 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 30):
    ENST00000548809 ENST00000548589 ENST00000551154 ENST00000546796 ENST00000549966
    ENST00000547832 ENST00000547187 ENST00000548894 ENST00000546914 ENST00000552635
    ENST00000552699 ENST00000267115(uc001rux.2 uc010sml.1) ENST00000549445
    ENST00000546885 ENST00000550951 ENST00000549385 ENST00000548713 ENST00000548201


    miRNA
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    8/74 QIAGEN miScript miRNA Assays for microRNAs that regulate TMBIM6 (see all 74):
    hsa-miR-1914* hsa-miR-106a hsa-miR-128 hsa-miR-1258 hsa-miR-519a hsa-miR-208b hsa-miR-93 hsa-miR-3613-3p
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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AF033095.1 AK026605.1 AK124849.1 AK130050.1 AK130462.1 AK225804.1 AK299587.1 AK304577.1 
    AK312238.1 AY736129.1 BC000916.1 BC036203.1 X75861.1 

    24/76 DOTS entries (see all 76):

    DT.100696479  DT.95156134  DT.91777584  DT.100696481  DT.95156204  DT.92413456  DT.100696501  DT.95156212 
    DT.121155648  DT.100870982  DT.100696505  DT.121155607  DT.97851577  DT.450807  DT.100696486  DT.95156116 
    DT.121155733  DT.100696498  DT.121155455  DT.100849067  DT.91775956  DT.121155632  DT.121155682  DT.95156106 

    24/2090 AceView cDNA sequences (see all 2090):

    CA446171 AI802037 AI760273 T08698 W37645 BF149378 BQ681274 BU164342 
    AA365964 AI818150 AA314089 BU176183 BQ217957 AI133352 BM852924 CB161117 
    AI682774 BQ672043 CR624817 AI095637 AA190412 BG739823 BM548855 BM770515 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TMBIM6 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14
    SP1:              -     -     -     -     -     -     -                                               -                                 
    SP2:                                                  -                                               -                                 
    SP3:                                      -     -     -                                               -                                 
    SP4:              -     -           -     -     -                                                                                       
    SP5:                                -     -     -     -                                                                                 


    ECgene alternative splicing isoforms for TMBIM6

    Expression
    for TMBIM6 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMBIM6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCACCCCGAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TMBIM6 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbLimb BudLimb
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TMBIM6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMBIM6

    SOURCE GeneReport for Unigene cluster: Hs.743965

    UniProtKB/Swiss-Prot: BI1_HUMAN, P55061
    Tissue specificity: Highly abundant in testis

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    In Situ
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    Orthologs
    for TMBIM6 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TMBIM6 gene from 7/26 species (see all 26)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Tmbim61 , 5 transmembrane BAX inhibitor motif containing 61, 5 86.22(n)1
    93.67(a)1    		   15 (56.13 cM)5
    1102131  NM_001171034.11  NP_001164505.11 
     993928825 
    lizard
    (Anolis carolinensis)    		 Reptilia TMBIM66
    		 --
    		 75(a)
    		 1 ↔ 1
    		 2(94667803-94675342)
    African clawed frog
    (Xenopus laevis)    		 Amphibia tegt-prov2 testis enhanced gene transcript 76.56(n)    BC047131.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii 570598322   -- 73.1(n)   373123  57059832 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG71881 CG7188 47.84(n)
    37.5(a)    		   38936  NM_139948.3  NP_648205.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons BI11 BAX inhibitor 1 51.54(n)
    44.93(a)    		   834758  NM_124083.2  NP_199523.1 
    rice
    (Oryza sativa)    		 Liliopsida Os02g01253001 hypothetical protein 49.7(n)
    42.41(a)    		   4328149  NM_001052280.1  NP_001045745.1 


    ENSEMBL Gene Tree for TMBIM6 (if available)
    TreeFam Gene Tree for TMBIM6 (if available) 

    Paralogs
    for TMBIM6 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for TMBIM6 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/537 NCBI SNPs in TMBIM6 are shown (see all 537)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1857780701,2
    		--50133371(+) TAAGGA/GACAAT 1 -- us2k10--------
    rs569456091,2
    		--50133379(+) AATGTG/AACCCC 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1903825281,2
    		--50133473(+) TGGATC/TGTCGA 1 -- us2k10--------
    rs781131121,2
    		C--50133554(+) ATCAGA/GGGCAA 1 -- us2k10--------
    rs2016308811,2
    		--50133573(+) AGATA-/TAGT  
                TAAAG     		1 -- us2k10--------
    rs778712761,2
    		C--50133588(+) CATGAC/TGAAAC 1 -- us2k10--------
    rs784492781,2
    		C--50133607(+) GTGCCA/TGTACA 2 -- us2k10--------
    rs1136815411,2
    		C,--50133609(+) GCCTGC/TACAAG 2 -- us2k13Minor allele frequency- T:0.25WA CSA 4
    rs1841097161,2
    		--50133658(+) GGTTCC/TCAGTG 2 -- us2k10--------
    rs1450275461,2
    		--50133687(+) CTTATA/CATAAA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for TMBIM6 (50101508 - 50158717 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TMBIM6: --

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    Disorders / Diseases
    for TMBIM6 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TMBIM6 for disorders           About GeneDecksing

    OMIM gene information: 600748    OMIM disorders: --

    14 diseases for TMBIM6:    About MalaCards
    lymphogranuloma venereum    inclusion conjunctivitis    conjunctivitis    fibrosarcoma
    liver disease    nasopharyngitis    prostate carcinoma    prostatitis
    prostate cancer    breast cancer    adenocarcinoma    carcinoma
    malaria    neuronitis

    1 Novoseek disease relationship for TMBIM6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 5 16353209 (3), 12875974 (1)

    Human Genome Epidemiology (HuGE) Navigator: TMBIM6 (4 documents)

    Export disorders for TMBIM6 gene to outside databases

    Publications
    for TMBIM6 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMBIM6 gene, integrated from 9 sources (see all 54):
    (articles sorted by number of sources associating them with TMBIM6)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast. (PubMed id 9660918)1, 2, 3 Xu Q. and Reed J.C. (1998)
    2. Identification of a novel conserved human gene, TEGT. (PubMed id 8530040)1, 2, 3 Walter L.... Guenther E. (1995)
    3. Six-transmembrane topology for Golgi anti-apoptotic protein (GAAP) and Bax inhibitor 1 (BI-1) provides model for the transmembrane Bax inhibitor-containing motif (TMBIM) family. (PubMed id 22418439)1, 2 Carrara G.... Smith G.L. (2012)
    4. The C terminus of Bax inhibitor-1 forms a Ca2+-permeable channel pore. (PubMed id 22128171)1, 2 Bultynck G.... Methner A. (2012)
    5. Endoplasmic reticulum protein BI-1 modulates unfolded protein response signaling and protects against stroke and traumatic brain inj ury. (PubMed id 21075086)1, 2 Krajewska M....Reed J.C. (2011)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. BI-1 regulates endoplasmic reticulum Ca2+ homeostasis downstream of Bcl-2 family proteins. (PubMed id 18299329)1, 9 Xu C....Reed J.C. (2008)
    8. Bax inhibitor 1 increases cell adhesion through actin polymerization: involvement of calcium and actin binding. (PubMed id 20123969)1, 9 Lee G.H....Chae H.J. (2010)
    9. Bax inhibitor-1 is overexpressed in prostate cancer and its specific down-regulation by RNA interference leads to cell death in human prostate carcinoma cells. (PubMed id 12875974)1, 9 Grzmil M....Burfeind P. (2003)
    10. Bax inhibitor-1 down-regulation in the progression of chronic liver diseases. (PubMed id 20359348)1, 9 Kotsafti A....Bortolami M. (2010)

    External Searches for TMBIM6 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TMBIM6 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7009 HGNC: 11723 AceView: TEGT Ensembl:ENSG00000139644 euGenes: HUgn7009
    ECgene: TMBIM6 H-InvDB: TMBIM6

    Other Databases showing TMBIM6 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TMBIM6 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMBIM6 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TMBIM6 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TMBIM6 gene:
    Search GeneIP for patents involving TMBIM6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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