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Aliases for TMBIM6 Gene

Aliases for TMBIM6 Gene

  • Transmembrane BAX Inhibitor Motif Containing 6 2 3
  • TEGT 3 4 6
  • Transmembrane BAX Inhibitor Motif-Containing Protein 6 3 4
  • Testis-Enhanced Gene Transcript Protein 3 4
  • Testis Enhanced Gene Transcript 2 3
  • BI-1 3 4
  • BAX Inhibitor 1 2
  • Bax Inhibitor 1 3
  • BAXI1 3
  • BI1 4

External Ids for TMBIM6 Gene

Previous Symbols for TMBIM6 Gene

  • TEGT

Summaries for TMBIM6 Gene

GeneCards Summary for TMBIM6 Gene

TMBIM6 (Transmembrane BAX Inhibitor Motif Containing 6) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMBIM6 Gene

  • Suppressor of apoptosis. Modulates unfolded protein response signaling. Modulate ER calcium homeostasis by acting as a calcium-leak channel.

Gene Wiki entry for TMBIM6 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMBIM6 Gene

Genomics for TMBIM6 Gene

Genomic Location for TMBIM6 Gene

Start:
49,707,725 bp from pter
End:
49,764,934 bp from pter
Size:
57,210 bases
Orientation:
Plus strand

Genomic View for TMBIM6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMBIM6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMBIM6 Gene

Regulatory Elements for TMBIM6 Gene

Proteins for TMBIM6 Gene

  • Protein details for TMBIM6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55061-BI1_HUMAN
    Recommended name:
    Bax inhibitor 1
    Protein Accession:
    P55061
    Secondary Accessions:
    • B2R5M4
    • F8W034
    • O14938
    • Q643A7
    • Q96J50

    Protein attributes for TMBIM6 Gene

    Size:
    237 amino acids
    Molecular mass:
    26538 Da
    Quaternary structure:
    • Interacts with BCL2 and BCL2L1/BCLX

    Alternative splice isoforms for TMBIM6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMBIM6 Gene

Proteomics data for TMBIM6 Gene at MOPED

Post-translational modifications for TMBIM6 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys7 and Lys15

No data available for DME Specific Peptides for TMBIM6 Gene

Domains for TMBIM6 Gene

Protein Domains for TMBIM6 Gene

UniProtKB/Swiss-Prot:

BI1_HUMAN
Domain:
  • The intra-membrane loop at the C-terminus acts as a calcium pore, mediating calcium leak from the ER into the cytosol:
    • P55061
Family:
  • Belongs to the BI1 family.:
    • P55061
genes like me logo Genes that share domains with TMBIM6: view

No data available for Gene Families for TMBIM6 Gene

Function for TMBIM6 Gene

Molecular function for TMBIM6 Gene

UniProtKB/Swiss-Prot Function: Suppressor of apoptosis. Modulates unfolded protein response signaling. Modulate ER calcium homeostasis by acting as a calcium-leak channel.

Gene Ontology (GO) - Molecular Function for TMBIM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 9660918
GO:0019899 enzyme binding IPI 19328063
GO:0031625 ubiquitin protein ligase binding IPI 21068390
GO:0060698 endoribonuclease inhibitor activity IDA 19328063
genes like me logo Genes that share ontologies with TMBIM6: view

Phenotypes for TMBIM6 Gene

genes like me logo Genes that share phenotypes with TMBIM6: view

miRNA for TMBIM6 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMBIM6 Gene

Localization for TMBIM6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMBIM6 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMBIM6 Gene COMPARTMENTS Subcellular localization image for TMBIM6 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 4
plasma membrane 4
mitochondrion 2

Gene Ontology (GO) - Cellular Components for TMBIM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 8530040
GO:0005737 cytoplasm IDA 9660918
GO:0005783 endoplasmic reticulum IDA 19328063
GO:0005789 endoplasmic reticulum membrane IDA 9660918
GO:0005887 integral component of plasma membrane TAS 10087504
genes like me logo Genes that share ontologies with TMBIM6: view

Pathways for TMBIM6 Gene

SuperPathways for TMBIM6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMBIM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process --
GO:0006986 response to unfolded protein IEA --
GO:0031438 negative regulation of mRNA cleavage IDA 19328063
GO:0032091 negative regulation of protein binding IDA 19328063
GO:0032469 endoplasmic reticulum calcium ion homeostasis IEA --
genes like me logo Genes that share ontologies with TMBIM6: view

No data available for Pathways by source for TMBIM6 Gene

Compounds for TMBIM6 Gene

(1) Novoseek inferred chemical compound relationships for TMBIM6 Gene

Compound -log(P) Hits PubMed IDs
calcium 0 2
genes like me logo Genes that share compounds with TMBIM6: view

Transcripts for TMBIM6 Gene

Unigene Clusters for TMBIM6 Gene

Transmembrane BAX inhibitor motif containing 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMBIM6 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14
SP1: - - - - - - - -
SP2: - -
SP3: - - - -
SP4: - - - - -
SP5: - - - -
SP6:
SP7:
SP8: - -

Relevant External Links for TMBIM6 Gene

GeneLoc Exon Structure for
TMBIM6
ECgene alternative splicing isoforms for
TMBIM6

Expression for TMBIM6 Gene

mRNA expression in normal human tissues for TMBIM6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMBIM6 Gene

SOURCE GeneReport for Unigene cluster for TMBIM6 Gene Hs.743965

mRNA Expression by UniProt/SwissProt for TMBIM6 Gene

P55061-BI1_HUMAN
Tissue specificity: Highly abundant in testis
genes like me logo Genes that share expressions with TMBIM6: view

Orthologs for TMBIM6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TMBIM6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMBIM6 36
  • 99.58 (n)
  • 99.58 (a)
TMBIM6 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMBIM6 36
  • 90.25 (n)
  • 92.58 (a)
TMBIM6 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMBIM6 36
  • 91.96 (n)
  • 93.86 (a)
TMBIM6 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmbim6 36
  • 86.26 (n)
  • 93.42 (a)
Tmbim6 16
Tmbim6 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 66 (a)
OneToMany
-- 37
  • 56 (a)
OneToMany
-- 37
  • 87 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tmbim6 36
  • 85.67 (n)
  • 91.23 (a)
lizard
(Anolis carolinensis)
Reptilia TMBIM6 37
  • 74 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia tegt-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7178 36
tmbim6 36
  • 72.22 (n)
  • 74.12 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9990 36
zebrafish
(Danio rerio)
Actinopterygii -- 36
tegt 36
  • 67.4 (n)
  • 67.4 (a)
tegt 37
  • 68 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005775 36
  • 51.2 (n)
  • 46.41 (a)
fruit fly
(Drosophila melanogaster)
Insecta BI-1 36
  • 48.2 (n)
  • 38.24 (a)
BI-1 37
  • 35 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons BI1 36
  • 51.29 (n)
  • 44.75 (a)
rice
(Oryza sativa)
Liliopsida Os02g0125300 36
  • 49.92 (n)
  • 41.86 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11346 37
  • 56 (a)
OneToOne
Species with no ortholog for TMBIM6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMBIM6 Gene

ENSEMBL:
Gene Tree for TMBIM6 (if available)
TreeFam:
Gene Tree for TMBIM6 (if available)

Paralogs for TMBIM6 Gene

No data available for Paralogs for TMBIM6 Gene

Variants for TMBIM6 Gene

Sequence variations from dbSNP and Humsavar for TMBIM6 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs4563 -- 49,758,410(+) GGCAC(A/G)GCAAT synonymous-codon, reference
rs7688 -- 49,763,288(+) CTCAT(C/T)GTTGT utr-variant-3-prime
rs717135 -- 49,762,715(+) AGGAT(A/G)TGGTT intron-variant
rs897056 -- 49,743,498(-) TAGCA(A/T)TTTGG intron-variant
rs1012874 -- 49,753,167(+) CCCTG(C/T)TCCTC intron-variant

Relevant External Links for TMBIM6 Gene

HapMap Linkage Disequilibrium report
TMBIM6

No data available for Structural Variations from Database of Genomic Variants (DGV) for TMBIM6 Gene

Disorders for TMBIM6 Gene

(1) Novoseek inferred disease relationships for TMBIM6 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 4

Relevant External Links for TMBIM6

Genetic Association Database (GAD)
TMBIM6
Human Genome Epidemiology (HuGE) Navigator
TMBIM6
genes like me logo Genes that share disorders with TMBIM6: view

No data available for UniProtKB/Swiss-Prot for TMBIM6 Gene

Publications for TMBIM6 Gene

  1. Identification of a novel conserved human gene, TEGT. (PMID: 8530040) Walter L. … Guenther E. (Genomics 1995) 2 3 4
  2. Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast. (PMID: 9660918) Xu Q. … Reed J.C. (Mol. Biol. Cell 1998) 2 3 4
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 49
  4. Bax inhibitor-1 down-regulation in the progression of chronic liver diseases. (PMID: 20359348) Kotsafti A. … Bortolami M. (BMC Gastroenterol 2010) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for TMBIM6 Gene

Sources for TMBIM6 Gene

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