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TMBIM6 Gene

protein-coding   GIFtS: 48
GCID: GC12P050101

Transmembrane BAX Inhibitor Motif Containing 6

(Previous name: testis enhanced gene transcript)
(Previous symbol: TEGT)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane BAX Inhibitor Motif Containing 61 2     Transmembrane BAX Inhibitor Motif-Containing Protein 62 3
TEGT1 2 3 5     BI-12 3
Testis Enhanced Gene Transcript1 2     BAXI12
BAX Inhibitor 11 2     BI13
Testis-Enhanced Gene Transcript Protein2 3     

External Ids:    HGNC: 117231   Entrez Gene: 70092   Ensembl: ENSG000001396447   OMIM: 6007485   UniProtKB: P550613   

Export aliases for TMBIM6 gene to outside databases

Previous GC identifers: GC12P048422 GC12P050135 GC12P047166


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMBIM6 Gene:
TMBIM6 (transmembrane BAX inhibitor motif containing 6) is a protein-coding gene. Diseases associated with TMBIM6 include inclusion conjunctivitis, and lymphogranuloma venereum.

UniProtKB/Swiss-Prot: BI1_HUMAN, P55061
Function: Suppressor of apoptosis. Modulates unfolded protein response signaling. Modulate ER calcium homeostasis
by acting as a calcium-leak channel

Gene Wiki entry for TMBIM6 (TEGT) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the TMBIM6 gene promoter:
         HOXA9   CHOP-10   FOXD1   ATF6   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 10): TMBIM6 promoter sequence
   Search Chromatin IP Primers for TMBIM6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMBIM6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.12   Ensembl cytogenetic band:  12q13.12   HGNC cytogenetic band: 12q13.12

TMBIM6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMBIM6 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P050101:  view genomic region     (about GC identifiers)

Start:
50,101,508 bp from pter      End:
50,158,717 bp from pter
Size:
57,210 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: BI1_HUMAN, P55061 (See protein sequence)
Recommended Name: Bax inhibitor 1  
Size: 237 amino acids; 26538 Da
Subunit: Interacts with BCL2 and BCL2L1/BCLX
Sequence caution: Sequence=AAH36203.2; Type=Erroneous initiation;
Secondary accessions: B2R5M4 O14938 Q643A7 Q96J50

Explore the universe of human proteins at neXtProt for TMBIM6: NX_P55061

Explore proteomics data for TMBIM6 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys7, Lys15
  • Modification sites at PhosphoSitePlus

  • See TMBIM6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001092046.1  NP_003208.2  

    ENSEMBL proteins: 
     ENSP00000449000   ENSP00000450417   ENSP00000450159   ENSP00000446668   ENSP00000448269  
     ENSP00000447400   ENSP00000447074   ENSP00000448612   ENSP00000450050   ENSP00000446734  
     ENSP00000267115   ENSP00000449904   ENSP00000449421   ENSP00000448036   ENSP00000447888  
     ENSP00000450265   ENSP00000449907   ENSP00000450305   ENSP00000450158   ENSP00000378454  
     ENSP00000447030   ENSP00000389277  

    TMBIM6 Human Recombinant Protein Products:

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    Novus Biologicals TMBIM6 Protein
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

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    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    ThermoFisher Antibodies for TMBIM6
    LSBio Antibodies in human, mouse, rat for TMBIM6

    TMBIM6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR006214 Bax_inhibitor_1-related
     IPR006213 Bax_inhbtr1_CS

    Graphical View of Domain Structure for InterPro Entry P55061

    ProtoNet protein and cluster: P55061

    1 Blocks protein domain: IPB006213 Bax inhibitor 1

    UniProtKB/Swiss-Prot: BI1_HUMAN, P55061
    Domain: The intra-membrane loop at the C-terminus acts as a calcium pore, mediating calcium leak from the ER into
    the cytosol
    Similarity: Belongs to the BI1 family


    TMBIM6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BI1_HUMAN, P55061
    Function: Suppressor of apoptosis. Modulates unfolded protein response signaling. Modulate ER calcium homeostasis
    by acting as a calcium-leak channel

    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tmbim6):

     homeostasis/metabolism  nervous system 

    TMBIM6 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMBIM6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TMBIM6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMBIM6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMBIM6

    miRNA
    Products:
        
    miRTarBase miRNAs that target TMBIM6:
    hsa-mir-16-5p (MIRT031401), hsa-mir-186-5p (MIRT045127), hsa-mir-155-5p (MIRT020530), hsa-mir-19b-3p (MIRT050638), hsa-mir-484 (MIRT042252)

    Block miRNA regulation of human, mouse, rat TMBIM6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TMBIM6 (see all 74):
    hsa-miR-1914* hsa-miR-106a hsa-miR-128 hsa-miR-1258 hsa-miR-519a hsa-miR-208b hsa-miR-93 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidTMBIM6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TMBIM6
    Predesigned siRNA for gene silencing in human, mouse, rat TMBIM6

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for TMBIM6 (see all 13)
    OriGene ORF clones in mouse, rat for TMBIM6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TMBIM6 (NM_003217)
    Sino Biological Human cDNA Clone for TMBIM6
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMBIM6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMBIM6

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for TMBIM6
    Browse ESI BIO Cell Lines and PureStem Progenitors for TMBIM6 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMBIM6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BI1_HUMAN, P55061: Endoplasmic reticulum membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    nucleus4
    plasma membrane4
    mitochondrion2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS8530040
    GO:0005783endoplasmic reticulum TAS10087504
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005887integral component of plasma membrane TAS10087504
    GO:0016021integral component of membrane ----

    TMBIM6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMBIM6
    Interactions:

        GeneGlobe Interaction Network for TMBIM6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for TMBIM6 (P550613 ENSP000003892774) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BCL2P104153, ENSP000003296234I2D: score=4 STRING: ENSP00000329623
    BADQ929343, ENSP000003091034I2D: score=1 STRING: ENSP00000309103
    BCL2L1Q078173, ENSP000003025644I2D: score=2 STRING: ENSP00000302564
    C1orf123Q9NWV43I2D: score=3 
    STAT6P422263I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0006986response to unfolded protein IEA--
    GO:0032469endoplasmic reticulum calcium ion homeostasis ----
    GO:0043066negative regulation of apoptotic process IEA--
    GO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ----

    TMBIM6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMBIM6 (BI1)

    1 Novoseek inferred chemical compound relationship for TMBIM6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 0 2 20193962 (2)



    TMBIM6 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TMBIM6 gene (2 alternative transcripts): 
    NM_001098576.1  NM_003217.2  

    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 28):
    ENST00000548809 ENST00000548589 ENST00000551154 ENST00000546796 ENST00000549966
    ENST00000547832 ENST00000547187 ENST00000548894 ENST00000546914 ENST00000552635
    ENST00000552699 ENST00000267115(uc001rux.2 uc010sml.1) ENST00000549445
    ENST00000546885 ENST00000550951 ENST00000549385 ENST00000548713 ENST00000548201

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TMBIM6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TMBIM6 (see all 74):
    hsa-miR-1914* hsa-miR-106a hsa-miR-128 hsa-miR-1258 hsa-miR-519a hsa-miR-208b hsa-miR-93 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidTMBIM6 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TMBIM6
    Predesigned siRNA for gene silencing in human, mouse, rat TMBIM6
    Clone
    Products:
         
    OriGene clones in human, mouse for TMBIM6 (see all 13)
    OriGene ORF clones in mouse, rat for TMBIM6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TMBIM6 (NM_003217)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMBIM6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMBIM6
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TMBIM6
    OriGene qSTAR qPCR primer pairs in human, mouse for TMBIM6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMBIM6
      QuantiTect SYBR Green Assays in human, mouse, rat TMBIM6
      QuantiFast Probe-based Assays in human, mouse, rat TMBIM6

    Selected AceView cDNA sequences (see all 2090):

    CA422265 AU141746 AI262363 AI753302 BU160248 CF125448 BE676801 BE349444 
    AA587467 BE272250 T40128 AI890067 AA305155 AI147798 BM562685 CF140750 
    BM742555 D57282 AA581953 BQ957457 BG163326 CA442881 BU157064 BP383317 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TMBIM6 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14
    SP1:              -     -     -     -     -     -     -                                               -                                 
    SP2:                                                  -                                               -                                 
    SP3:                                      -     -     -                                               -                                 
    SP4:              -     -           -     -     -                                                                                       
    SP5:                                -     -     -     -                                                                                 


    ECgene alternative splicing isoforms for TMBIM6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMBIM6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCACCCCGAA
    TMBIM6 Expression
    About this image


    TMBIM6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
    TMBIM6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMBIM6 Protein Expression

    UniProtKB/Swiss-Prot: BI1_HUMAN, P55061
    Tissue specificity: Highly abundant in testis

        Custom PCR Arrays for TMBIM6
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat TMBIM6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMBIM6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TMBIM6 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmbim61 , 5 transmembrane BAX inhibitor motif containing 61, 5 86.26(n)1
    93.42(a)1
      15 (56.13 cM)5
    1102131  NM_001171035.11  NP_001164506.11 
     993928825 
    lizard
    (Anolis carolinensis)
    Reptilia TMBIM66
    transmembrane BAX inhibitor motif containing 6
    74(a)
    1 ↔ 1
    2(94667792-94675342)
    African clawed frog
    (Xenopus laevis)
    Amphibia tegt-prov2 testis enhanced gene transcript 76.56(n)    BC047131.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570598322   -- 73.1(n)   373123  57059832 
    fruit fly
    (Drosophila melanogaster)
    Insecta BI-11 Bax Inhibitor-1 48.2(n)
    38.24(a)
      38936  NM_139948.4  NP_648205.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons BI11 BI1 51.29(n)
    44.75(a)
      834758  NM_124083.2  NP_199523.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g01253001 Os02g0125300 49.92(n)
    41.86(a)
      4328149  NM_001052280.1  NP_001045745.1 


    ENSEMBL Gene Tree for TMBIM6 (if available)
    TreeFam Gene Tree for TMBIM6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMBIM6 (see all 676)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1857780701,2
    --50133371(+) TAAGGA/GACAAT 1 -- us2k10--------
    rs569456091,2
    C,F--50133379(+) AATGTG/AACCCC 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1903825281,2
    --50133473(+) TGGATC/TGTCGA 1 -- us2k10--------
    rs1996713031,2
    C--50133528(+) TACCAA/CTTGCT 1 -- us2k10--------
    rs781131121,2
    C--50133554(+) ATCAGA/GGGCAA 1 -- us2k10--------
    rs778712761,2
    C--50133588(+) CATGAC/TGAAAC 1 -- us2k10--------
    rs784492781,2
    C--50133607(+) GTGCCA/TGTACA 2 -- us2k10--------
    rs1136815411,2
    C--50133609(+) GCCTGC/TACAAG 2 -- us2k13Minor allele frequency- T:0.25WA CSA 4
    rs1841097161,2
    --50133658(+) GGTTCC/TCAGTG 2 -- us2k10--------
    rs1450275461,2
    --50133687(+) CTTATA/CATAAA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for TMBIM6 (50101508 - 50158717 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TMBIM6: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TMBIM6
    DNA2.0 Custom Variant and Variant Library Synthesis for TMBIM6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600748    OMIM disorders: --

    15 diseases for TMBIM6:    
    About MalaCards
    inclusion conjunctivitis    lymphogranuloma venereum    conjunctivitis    traumatic brain injury
    fibrosarcoma    brain injury    nasopharyngitis    liver disease
    adenocarcinoma    prostatitis    prostate cancer    alzheimer's disease
    malaria    breast cancer    neuronitis


    TMBIM6 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for TMBIM6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 5 16353209 (3), 12875974 (1)

    Genetic Association Database (GAD): TMBIM6
    Human Genome Epidemiology (HuGE) Navigator: TMBIM6 (4 documents)

    Export disorders for TMBIM6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMBIM6 gene, integrated from 10 sources (see all 60):
    (articles sorted by number of sources associating them with TMBIM6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast. (PubMed id 9660918)1, 2, 3 Xu Q. and Reed J.C. (Mol. Biol. Cell 1998)
    2. Identification of a novel conserved human gene, TEGT. (PubMed id 8530040)1, 2, 3 Walter L.... Guenther E. (Genomics 1995)
    3. Six-transmembrane topology for Golgi anti-apoptotic protein (GAAP) and Bax inhibitor 1 (BI-1) provides model for the transmembrane Bax inhibitor-containing motif (TMBIM) family. (PubMed id 22418439)1, 2 Carrara G.... Smith G.L. (J. Biol. Chem. 2012)
    4. The C terminus of Bax inhibitor-1 forms a Ca2+-permeable channel pore. (PubMed id 22128171)1, 2 Bultynck G.... Methner A. (J. Biol. Chem. 2012)
    5. Endoplasmic reticulum protein BI-1 modulates unfolded protein response signaling and protects against stroke and traumatic brain injury. (PubMed id 21075086)1, 2 Krajewska M.... Reed J.C. (Brain Res. 2011)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. BI-1 regulates endoplasmic reticulum Ca2+ homeostasis downstream of Bcl-2 family proteins. (PubMed id 18299329)1, 9 Xu C....Reed J.C. (J. Biol. Chem. 2008)
    9. Bax inhibitor 1 increases cell adhesion through actin polymerization: involvement of calcium and actin binding. (PubMed id 20123969)1, 9 Lee G.H....Chae H.J. (Mol. Cell. Biol. 2010)
    10. Bax inhibitor-1 is overexpressed in prostate cancer and its specific down-regulation by RNA interference leads to cell death in human prostate carcinoma cells. (PubMed id 12875974)1, 9 Grzmil M....Burfeind P. (Am. J. Pathol. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Disorders
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7009 HGNC: 11723 AceView: TEGT Ensembl:ENSG00000139644 euGenes: HUgn7009
    ECgene: TMBIM6 H-InvDB: TMBIM6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TMBIM6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMBIM6 gene:
    Search GeneIP for patents involving TMBIM6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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