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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMBIM6 Gene

protein-coding   GIFtS: 49
GCID: GC12P050101

Transmembrane BAX Inhibitor Motif Containing 6

(Previous name: testis enhanced gene transcript)
(Previous symbol: TEGT)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transmembrane BAX Inhibitor Motif Containing 61 2     Transmembrane BAX Inhibitor Motif-Containing Protein 62 3
TEGT1 2 3 5     BI-12 3
Testis Enhanced Gene Transcript1 2     BAXI12
BAX Inhibitor 11 2     BI13
Testis-Enhanced Gene Transcript Protein2 3     

External Ids:    HGNC: 117231   Entrez Gene: 70092   Ensembl: ENSG000001396447   OMIM: 6007485   UniProtKB: P550613   

Export aliases for TMBIM6 gene to outside databases

Previous GC identifers: GC12P048422 GC12P050135 GC12P047166


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TMBIM6 Gene: 
TMBIM6 (transmembrane BAX inhibitor motif containing 6) is a protein-coding gene. Diseases associated with TMBIM6 include inclusion conjunctivitis, and lymphogranuloma venereum.

UniProtKB/Swiss-Prot: BI1_HUMAN, P55061
Function: Suppressor of apoptosis. Modulates unfolded protein response signaling. Modulate ER calcium homeostasis
by acting as a calcium-leak channel

Gene Wiki entry for TMBIM6 (TEGT) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMBIM6 gene promoter:
         HOXA9   CHOP-10   FOXD1   ATF6   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 10): TMBIM6 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMBIM6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMBIM6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q12-q13   Ensembl cytogenetic band:  12q13.12   HGNC cytogenetic band: 12q12-q13

TMBIM6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMBIM6 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P050101:  view genomic region     (about GC identifiers)

Start:
50,101,508 bp from pter      End:
50,158,717 bp from pter
Size:
57,210 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BI1_HUMAN, P55061 (See protein sequence)
Recommended Name: Bax inhibitor 1  
Size: 237 amino acids; 26538 Da
Subunit: Interacts with BCL2 and BCL2L1/BCLX
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Sequence caution: Sequence=AAH36203.2; Type=Erroneous initiation;
Secondary accessions: B2R5M4 O14938 Q643A7 Q96J50

Explore the universe of human proteins at neXtProt for TMBIM6: NX_P55061

Explore proteomics data for TMBIM6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P55061

  • TMBIM6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TMBIM6 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001092046.1  NP_003208.2  

    ENSEMBL proteins: 
     ENSP00000449000   ENSP00000450417   ENSP00000450159   ENSP00000446668   ENSP00000448269  
     ENSP00000447400   ENSP00000447074   ENSP00000448612   ENSP00000450050   ENSP00000446734  
     ENSP00000267115   ENSP00000449904   ENSP00000449421   ENSP00000448036   ENSP00000447888  
     ENSP00000450265   ENSP00000449907   ENSP00000450305   ENSP00000450158   ENSP00000378454  
     ENSP00000447030   ENSP00000389277  

    Human Recombinant Protein Products for TMBIM6: 
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    Novus Biologicals TMBIM6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS8530040
    GO:0005783endoplasmic reticulum TAS10087504
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005887integral to plasma membrane TAS10087504
    GO:0016021integral to membrane ----

    TMBIM6 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR006214 Bax_inhibitor_1-related
     IPR006213 Bax_inhbtr1_CS

    Graphical View of Domain Structure for InterPro Entry P55061

    ProtoNet protein and cluster: P55061

    1 Blocks protein domain: IPB006213 Bax inhibitor 1

    UniProtKB/Swiss-Prot: BI1_HUMAN, P55061
    Domain: The intra-membrane loop at the C-terminus acts as a calcium pore, mediating calcium leak from the ER into
    the cytosol
    Similarity: Belongs to the BI1 family


    TMBIM6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BI1_HUMAN, P55061
    Function: Suppressor of apoptosis. Modulates unfolded protein response signaling. Modulate ER calcium homeostasis
    by acting as a calcium-leak channel

    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tmbim6):

     homeostasis/metabolism  nervous system 

    TMBIM6 for phenotypes           About GeneDecksing

    Animal Models:
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMBIM6 
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    SwitchGear 3'UTR luciferase reporter plasmidTMBIM6 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TMBIM6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/15 Interacting proteins for TMBIM6 (P550613 ENSP000003892774) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BCL2P104153, ENSP000003296234I2D: score=4 STRING: ENSP00000329623
    BADQ929343, ENSP000003091034I2D: score=1 STRING: ENSP00000309103
    BCL2L1Q078173, ENSP000003025644I2D: score=2 STRING: ENSP00000302564
    C1orf123Q9NWV43I2D: score=3 
    STAT6P422263I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0006986response to unfolded protein IEA--
    GO:0032469endoplasmic reticulum calcium ion homeostasis ----
    GO:0043066negative regulation of apoptotic process IEA--
    GO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ----

    TMBIM6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TMBIM6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMBIM6 (BI1)

    1 Novoseek inferred chemical compound relationship for TMBIM6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 0 2 20193962 (2)

    Search CenterWatch for drugs/clinical trials and news about TMBIM6 / BI1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TMBIM6 gene (2 alternative transcripts): 
    NM_001098576.1  NM_003217.2  

    Unigene Cluster for TMBIM6:

    Transmembrane BAX inhibitor motif containing 6
    Hs.743965  [show with all ESTs]
    Unigene Representative Sequence: NM_001098576
    18/28 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 28):
    ENST00000548809 ENST00000548589 ENST00000551154 ENST00000546796 ENST00000549966
    ENST00000547832 ENST00000547187 ENST00000548894 ENST00000546914 ENST00000552635
    ENST00000552699 ENST00000267115(uc001rux.2 uc010sml.1) ENST00000549445
    ENST00000546885 ENST00000550951 ENST00000549385 ENST00000548713 ENST00000548201

    miRNA
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    8/74 QIAGEN miScript miRNA Assays for microRNAs that regulate TMBIM6 (see all 74):
    hsa-miR-1914* hsa-miR-106a hsa-miR-128 hsa-miR-1258 hsa-miR-519a hsa-miR-208b hsa-miR-93 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidTMBIM6 3' UTR sequence
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    Additional mRNA sequence: 

    AF033095.1 AK026605.1 AK124849.1 AK130050.1 AK130462.1 AK225804.1 AK299587.1 AK304577.1 
    AK312238.1 AY736129.1 BC000916.1 BC036203.1 X75861.1 

    24/75 DOTS entries (see all 75):

    DT.100696479  DT.95156134  DT.91777584  DT.100696481  DT.95156204  DT.92413456  DT.100696501  DT.95156212 
    DT.121155648  DT.100870982  DT.100696505  DT.121155607  DT.97851577  DT.450807  DT.100696486  DT.95156116 
    DT.121155733  DT.100696498  DT.121155455  DT.100849067  DT.91775956  DT.121155632  DT.121155682  DT.95156106 

    24/2090 AceView cDNA sequences (see all 2090):

    AI678019 AW027340 AI699191 AA315412 CB265645 BM697481 AI201260 CB126186 
    AI683484 AU130814 AA552603 BM750944 BM727048 BF058111 BM756934 AL549102 
    BM745127 BM835636 AI811736 AI357320 BQ948462 CB306634 BM794621 AA324791 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TMBIM6 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14
    SP1:              -     -     -     -     -     -     -                                               -                                 
    SP2:                                                  -                                               -                                 
    SP3:                                      -     -     -                                               -                                 
    SP4:              -     -           -     -     -                                                                                       
    SP5:                                -     -     -     -                                                                                 


    ECgene alternative splicing isoforms for TMBIM6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMBIM6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCACCCCGAA
    TMBIM6 Expression
    About this image


    See TMBIM6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMBIM6

    SOURCE GeneReport for Unigene cluster: Hs.743965

    UniProtKB/Swiss-Prot: BI1_HUMAN, P55061
    Tissue specificity: Highly abundant in testis

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TMBIM6 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmbim61 , 5 transmembrane BAX inhibitor motif containing 61, 5 86.22(n)1
    93.67(a)1
      15 (56.13 cM)5
    1102131  NM_001171034.11  NP_001164505.11 
     993928825 
    lizard
    (Anolis carolinensis)
    Reptilia TMBIM66
    Uncharacterized protein
    74(a)
    1 ↔ 1
    2(94667792-94675342)
    African clawed frog
    (Xenopus laevis)
    Amphibia tegt-prov2 testis enhanced gene transcript 76.56(n)    BC047131.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570598322   -- 73.1(n)   373123  57059832 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG71881 CG7188 47.84(n)
    37.5(a)
      38936  NM_139948.3  NP_648205.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons BI11 BAX inhibitor 1 51.54(n)
    44.93(a)
      834758  NM_124083.2  NP_199523.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g01253001 hypothetical protein 49.7(n)
    42.41(a)
      4328149  NM_001052280.1  NP_001045745.1 


    ENSEMBL Gene Tree for TMBIM6 (if available)
    TreeFam Gene Tree for TMBIM6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/676 SNPs in TMBIM6 are shown (see all 676)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1857780701,2
    --50133371(+) TAAGGA/GACAAT 1 -- us2k10--------
    rs569456091,2
    C,F--50133379(+) AATGTG/AACCCC 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1903825281,2
    --50133473(+) TGGATC/TGTCGA 1 -- us2k10--------
    rs1996713031,2
    C--50133528(+) TACCAA/CTTGCT 1 -- us2k10--------
    rs781131121,2
    C--50133554(+) ATCAGA/GGGCAA 1 -- us2k10--------
    rs778712761,2
    C--50133588(+) CATGAC/TGAAAC 1 -- us2k10--------
    rs784492781,2
    C--50133607(+) GTGCCA/TGTACA 2 -- us2k10--------
    rs1136815411,2
    C--50133609(+) GCCTGC/TACAAG 2 -- us2k13Minor allele frequency- T:0.25WA CSA 4
    rs1841097161,2
    --50133658(+) GGTTCC/TCAGTG 2 -- us2k10--------
    rs1450275461,2
    --50133687(+) CTTATA/CATAAA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for TMBIM6 (50101508 - 50158717 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TMBIM6: --
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600748    OMIM disorders: --

    12 diseases for TMBIM6:    About MalaCards
    inclusion conjunctivitis    lymphogranuloma venereum    conjunctivitis    fibrosarcoma
    cytochrome p450    nasopharyngitis    liver disease    prostatitis
    adenocarcinoma    prostate cancer    breast cancer    neuronitis


    TMBIM6 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for TMBIM6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 5 16353209 (3), 12875974 (1)

    Genetic Association Database (GAD): TMBIM6
    Human Genome Epidemiology (HuGE) Navigator: TMBIM6 (4 documents)

    Export disorders for TMBIM6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMBIM6 gene, integrated from 9 sources (see all 58):
    (articles sorted by number of sources associating them with TMBIM6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast. (PubMed id 9660918)1, 2, 3 Xu Q. and Reed J.C. (1998)
    2. Identification of a novel conserved human gene, TEGT. (PubMed id 8530040)1, 2, 3 Walter L.... Guenther E. (1995)
    3. Six-transmembrane topology for Golgi anti-apoptotic protein (GAAP) and Bax inhibitor 1 (BI-1) provides model for the transmembrane Bax inhibitor-containing motif (TMBIM) family. (PubMed id 22418439)1, 2 Carrara G.... Smith G.L. (2012)
    4. The C terminus of Bax inhibitor-1 forms a Ca2+-permeable channel pore. (PubMed id 22128171)1, 2 Bultynck G.... Methner A. (2012)
    5. Endoplasmic reticulum protein BI-1 modulates unfolded protein response signaling and protects against stroke and traumatic brain inj ury. (PubMed id 21075086)1, 2 Krajewska M....Reed J.C. (2011)
    6. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. BI-1 regulates endoplasmic reticulum Ca2+ homeostasis downstream of Bcl-2 family proteins. (PubMed id 18299329)1, 9 Xu C....Reed J.C. (2008)
    9. Bax inhibitor 1 increases cell adhesion through actin polymerization: involvement of calcium and actin binding. (PubMed id 20123969)1, 9 Lee G.H....Chae H.J. (2010)
    10. Bax inhibitor-1 is overexpressed in prostate cancer and its specific down-regulation by RNA interference leads to cell death in human prostate carcinoma cells. (PubMed id 12875974)1, 9 Grzmil M....Burfeind P. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7009 HGNC: 11723 AceView: TEGT Ensembl:ENSG00000139644 euGenes: HUgn7009
    ECgene: TMBIM6 H-InvDB: TMBIM6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMBIM6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TMBIM6 gene:
    Search GeneIP for patents involving TMBIM6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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