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Aliases for TMBIM4 Gene

Aliases for TMBIM4 Gene

  • Transmembrane BAX Inhibitor Motif Containing 4 5 2 3
  • Transmembrane BAX Inhibitor Motif-Containing Protein 4 3 4
  • Golgi Anti-Apoptotic Protein 3 4
  • Z-Protein 3 4
  • GAAP 3 4
  • LFG4 3 4
  • Protein S1R 4
  • CGI-119 3
  • ZPRO 3
  • S1R 3

External Ids for TMBIM4 Gene

Previous GeneCards Identifiers for TMBIM4 Gene

  • GC12M064818
  • GC12M066531
  • GC12M063581
  • GC12M066518

Summaries for TMBIM4 Gene

GeneCards Summary for TMBIM4 Gene

TMBIM4 (Transmembrane BAX Inhibitor Motif Containing 4) is a Protein Coding gene. Diseases associated with TMBIM4 include Lassa Fever and Venezuelan Hemorrhagic Fever. An important paralog of this gene is FAIM2.

UniProtKB/Swiss-Prot for TMBIM4 Gene

  • Anti-apoptotic protein which can inhibit apoptosis induced by intrinsic and extrinsic apoptotic stimuli. Can modulate both capacitative Ca2+ entry and inositol 1,4,5-trisphosphate (IP3)-mediated Ca2+ release.

Gene Wiki entry for TMBIM4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMBIM4 Gene

Genomics for TMBIM4 Gene

Regulatory Elements for TMBIM4 Gene

Enhancers for TMBIM4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMBIM4 on UCSC Golden Path with GeneCards custom track

Promoters for TMBIM4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMBIM4 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMBIM4 Gene

66,135,846 bp from pter
66,170,072 bp from pter
34,227 bases
Minus strand

Genomic View for TMBIM4 Gene

Genes around TMBIM4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMBIM4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMBIM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMBIM4 Gene

Proteins for TMBIM4 Gene

  • Protein details for TMBIM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein lifeguard 4
    Protein Accession:
    Secondary Accessions:
    • Q542Z6
    • Q9UHY5
    • Q9Y3C2

    Protein attributes for TMBIM4 Gene

    238 amino acids
    Molecular mass:
    26971 Da
    Quaternary structure:
    • Interacts with ITPR3.
    • Sequence=AAD34114.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for TMBIM4 Gene

Proteomics data for TMBIM4 Gene at MOPED

Post-translational modifications for TMBIM4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for TMBIM4

No data available for DME Specific Peptides for TMBIM4 Gene

Domains & Families for TMBIM4 Gene

Gene Families for TMBIM4 Gene

Protein Domains for TMBIM4 Gene


Suggested Antigen Peptide Sequences for TMBIM4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the BI1 family. LFG subfamily.
  • Belongs to the BI1 family. LFG subfamily.
genes like me logo Genes that share domains with TMBIM4: view

Function for TMBIM4 Gene

Molecular function for TMBIM4 Gene

UniProtKB/Swiss-Prot Function:
Anti-apoptotic protein which can inhibit apoptosis induced by intrinsic and extrinsic apoptotic stimuli. Can modulate both capacitative Ca2+ entry and inositol 1,4,5-trisphosphate (IP3)-mediated Ca2+ release.
genes like me logo Genes that share phenotypes with TMBIM4: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMBIM4 Gene

Localization for TMBIM4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMBIM4 Gene

Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMBIM4 Gene COMPARTMENTS Subcellular localization image for TMBIM4 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 4
endoplasmic reticulum 2
cytosol 1
endosome 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TMBIM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005795 Golgi stack IDA 17319741
genes like me logo Genes that share ontologies with TMBIM4: view

Pathways & Interactions for TMBIM4 Gene

SuperPathways for TMBIM4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMBIM4 Gene


No data available for Pathways by source and SIGNOR curated interactions for TMBIM4 Gene

Drugs & Compounds for TMBIM4 Gene

(2) Drugs for TMBIM4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for TMBIM4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TMBIM4: view

Transcripts for TMBIM4 Gene

Unigene Clusters for TMBIM4 Gene

Transmembrane BAX inhibitor motif containing 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMBIM4 Gene

No ASD Table

Relevant External Links for TMBIM4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMBIM4 Gene

mRNA expression in normal human tissues for TMBIM4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMBIM4 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMBIM4 Gene

SOURCE GeneReport for Unigene cluster for TMBIM4 Gene Hs.505934

genes like me logo Genes that share expression patterns with TMBIM4: view

Protein tissue co-expression partners for TMBIM4 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMBIM4 Gene

Orthologs for TMBIM4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TMBIM4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMBIM4 35
  • 88.66 (n)
  • 85.71 (a)
CGI-119 36
  • 86 (a)
(Canis familiaris)
Mammalia TMBIM4 35
  • 89.22 (n)
  • 88.66 (a)
-- 36
  • 89 (a)
(Mus musculus)
Mammalia Tmbim4 35
  • 82.07 (n)
  • 84.03 (a)
Tmbim4 16
Tmbim4 36
  • 84 (a)
(Pan troglodytes)
Mammalia TMBIM4 35
  • 99.44 (n)
  • 98.32 (a)
-- 36
  • 82 (a)
(Rattus norvegicus)
Mammalia Tmbim4 35
  • 82.77 (n)
  • 84.03 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 82 (a)
(Gallus gallus)
Aves TMBIM4 35
  • 75.46 (n)
  • 77.45 (a)
-- 36
  • 77 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11131 35
tmbim4 35
  • 68.23 (n)
  • 70.21 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6302 35
(Danio rerio)
Actinopterygii tmbim4 35
  • 64.23 (n)
  • 65.67 (a)
zgc66343 35
tmbim4 36
  • 65 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG30379 36
  • 23 (a)
(Caenorhabditis elegans)
Secernentea tmbi-4 35
  • 46.96 (n)
  • 35.11 (a)
tmbi-4 36
  • 29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BXI1 36
  • 27 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G15470 35
  • 50.24 (n)
  • 41.15 (a)
(Oryza sativa)
Liliopsida Os05g0402300 35
  • 46.79 (n)
  • 36.06 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4667 35
bread mold
(Neurospora crassa)
Ascomycetes NCU02463 35
  • 47.39 (n)
  • 42.61 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes bxi1 35
  • 50.86 (n)
  • 39.66 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8799 36
  • 48 (a)
Species with no ortholog for TMBIM4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMBIM4 Gene

Gene Tree for TMBIM4 (if available)
Gene Tree for TMBIM4 (if available)

Paralogs for TMBIM4 Gene

Paralogs for TMBIM4 Gene

genes like me logo Genes that share paralogs with TMBIM4: view

Variants for TMBIM4 Gene

Sequence variations from dbSNP and Humsavar for TMBIM4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs8793 - 66,152,320(-) GTTGA(C/T)TTTAA reference, missense
rs11176070 - 66,169,947(+) GGTCA(A/G)CCATG reference, missense, utr-variant-5-prime
rs1946750 -- 66,141,241(+) AAAAG(A/C)TAATA intron-variant
rs1967338 -- 66,169,323(-) GGATT(A/G)TTGAG intron-variant
rs2043669 -- 66,158,226(-) ttttg(G/T)gagac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMBIM4 Gene

Variant ID Type Subtype PubMed ID
nsv899214 CNV Loss 21882294
nsv526076 CNV Loss 19592680
nsv899215 CNV Loss 21882294

Variation tolerance for TMBIM4 Gene

Residual Variation Intolerance Score: 53.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.54; 86.01% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TMBIM4 Gene

Disorders for TMBIM4 Gene

MalaCards: The human disease database

(4) MalaCards diseases for TMBIM4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lassa fever
  • lf
venezuelan hemorrhagic fever
  • guanarito hemorrhagic fever
lymphocytic choriomeningitis
  • lcm
bolivian hemorrhagic fever
  • machupo hemorrhagic fever
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TMBIM4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TMBIM4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMBIM4 Gene

Publications for TMBIM4 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4 67
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3
  3. The transmembrane Bax inhibitor motif (TMBIM) containing protein family: Tissue expression, intracellular localization and effects on the ER CAA^a8_-filling state. (PMID: 25764978) Lisak D.A. … Methner A. (Biochim. Biophys. Acta 2015) 3
  4. Host cell Golgi anti-apoptotic protein (GAAP) and growth of Chlamydia pneumoniae. (PMID: 23000903) Markkula E. … Puolakkainen M. (Microb. Pathog. 2013) 3
  5. Human and viral Golgi anti-apoptotic proteins (GAAPs) oligomerize via different mechanisms and monomeric GAAP inhibits apoptosis and modulates calcium. (PMID: 23508950) Saraiva N. … Smith G.L. (J. Biol. Chem. 2013) 3

Products for TMBIM4 Gene

Sources for TMBIM4 Gene