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Aliases for TMBIM4 Gene

Aliases for TMBIM4 Gene

  • Transmembrane BAX Inhibitor Motif Containing 4 2 3
  • Transmembrane BAX Inhibitor Motif-Containing Protein 4 3 4
  • Golgi Anti-Apoptotic Protein 3 4
  • Z-Protein 3 4
  • GAAP 3 4
  • LFG4 3 4
  • Protein Lifeguard 4 3
  • Protein S1R 4
  • CGI-119 3
  • ZPRO 3
  • S1R 3

External Ids for TMBIM4 Gene

Summaries for TMBIM4 Gene

GeneCards Summary for TMBIM4 Gene

TMBIM4 (Transmembrane BAX Inhibitor Motif Containing 4) is a Protein Coding gene. Diseases associated with TMBIM4 include argentine hemorrhagic fever and venezuelan hemorrhagic fever. An important paralog of this gene is FAIM2.

UniProtKB/Swiss-Prot for TMBIM4 Gene

  • Anti-apoptotic protein which can inhibit apoptosis induced by intrinsic and extrinsic apoptotic stimuli. Can modulate both capacitative Ca2+ entry and inositol 1,4,5-trisphosphate (IP3)-mediated Ca2+ release.

Gene Wiki entry for TMBIM4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMBIM4 Gene

Genomics for TMBIM4 Gene

Genomic Location for TMBIM4 Gene

Start:
66,135,846 bp from pter
End:
66,170,072 bp from pter
Size:
34,227 bases
Orientation:
Minus strand

Genomic View for TMBIM4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMBIM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMBIM4 Gene

Regulatory Elements for TMBIM4 Gene

Proteins for TMBIM4 Gene

  • Protein details for TMBIM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HC24-LFG4_HUMAN
    Recommended name:
    Protein lifeguard 4
    Protein Accession:
    Q9HC24
    Secondary Accessions:
    • Q542Z6
    • Q9UHY5
    • Q9Y3C2

    Protein attributes for TMBIM4 Gene

    Size:
    238 amino acids
    Molecular mass:
    26971 Da
    Quaternary structure:
    • Interacts with ITPR3.
    SequenceCaution:
    • Sequence=AAD34114.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for TMBIM4 Gene

Proteomics data for TMBIM4 Gene at MOPED

Post-translational modifications for TMBIM4 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TMBIM4 Gene

Domains for TMBIM4 Gene

Protein Domains for TMBIM4 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

LFG4_HUMAN
Family:
  • Belongs to the BI1 family. LFG subfamily.:
    • Q9HC24
genes like me logo Genes that share domains with TMBIM4: view

No data available for Gene Families for TMBIM4 Gene

Function for TMBIM4 Gene

Molecular function for TMBIM4 Gene

UniProtKB/Swiss-Prot Function: Anti-apoptotic protein which can inhibit apoptosis induced by intrinsic and extrinsic apoptotic stimuli. Can modulate both capacitative Ca2+ entry and inositol 1,4,5-trisphosphate (IP3)-mediated Ca2+ release.

Gene Ontology (GO) - Molecular Function for TMBIM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19553469
genes like me logo Genes that share ontologies with TMBIM4: view

Phenotypes for TMBIM4 Gene

GenomeRNAi human phenotypes for TMBIM4:
genes like me logo Genes that share phenotypes with TMBIM4: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TMBIM4 Gene

Localization for TMBIM4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMBIM4 Gene

Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMBIM4 Gene COMPARTMENTS Subcellular localization image for TMBIM4 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 3
cytosol 1
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TMBIM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005795 Golgi stack IDA 17319741
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMBIM4: view

Pathways for TMBIM4 Gene

SuperPathways for TMBIM4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMBIM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0043066 negative regulation of apoptotic process IMP 17319741
GO:0050848 regulation of calcium-mediated signaling IDA 19553469
genes like me logo Genes that share ontologies with TMBIM4: view

No data available for Pathways by source for TMBIM4 Gene

Compounds for TMBIM4 Gene

(3) Novoseek inferred chemical compound relationships for TMBIM4 Gene

Compound -log(P) Hits PubMed IDs
phospholipid 37.1 2
serine 16.2 1
calcium 0 1
genes like me logo Genes that share compounds with TMBIM4: view

Transcripts for TMBIM4 Gene

Unigene Clusters for TMBIM4 Gene

Transmembrane BAX inhibitor motif containing 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMBIM4 Gene

No ASD Table

Relevant External Links for TMBIM4 Gene

GeneLoc Exon Structure for
TMBIM4
ECgene alternative splicing isoforms for
TMBIM4

Expression for TMBIM4 Gene

mRNA expression in normal human tissues for TMBIM4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TMBIM4 Gene

SOURCE GeneReport for Unigene cluster for TMBIM4 Gene Hs.505934

genes like me logo Genes that share expressions with TMBIM4: view

Orthologs for TMBIM4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TMBIM4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 82 (a)
OneToMany
TMBIM4 36
  • 99.44 (n)
  • 98.32 (a)
cow
(Bos Taurus)
Mammalia CGI-119 37
  • 86 (a)
OneToMany
TMBIM4 36
  • 88.66 (n)
  • 85.71 (a)
dog
(Canis familiaris)
Mammalia -- 37
  • 89 (a)
OneToMany
TMBIM4 36
  • 89.22 (n)
  • 88.66 (a)
mouse
(Mus musculus)
Mammalia Tmbim4 36
  • 82.07 (n)
  • 84.03 (a)
Tmbim4 16
Tmbim4 37
  • 84 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 75 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 82 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tmbim4 36
  • 82.77 (n)
  • 84.03 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 77 (a)
OneToMany
TMBIM4 36
  • 75.46 (n)
  • 77.45 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 77 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.6302 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11131 36
tmbim4 36
  • 68.23 (n)
  • 70.21 (a)
zebrafish
(Danio rerio)
Actinopterygii tmbim4 36
  • 64.23 (n)
  • 65.67 (a)
tmbim4 37
  • 65 (a)
OneToMany
zgc66343 36
fruit fly
(Drosophila melanogaster)
Insecta CG30379 37
  • 23 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea tmbi-4 36
  • 46.96 (n)
  • 35.11 (a)
tmbi-4 37
  • 29 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BXI1 37
  • 27 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G15470 36
  • 50.24 (n)
  • 41.15 (a)
rice
(Oryza sativa)
Liliopsida Os05g0402300 36
  • 46.79 (n)
  • 36.06 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02463 36
  • 47.39 (n)
  • 42.61 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes bxi1 36
  • 50.86 (n)
  • 39.66 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4667 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8799 37
  • 48 (a)
OneToMany
Species with no ortholog for TMBIM4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMBIM4 Gene

ENSEMBL:
Gene Tree for TMBIM4 (if available)
TreeFam:
Gene Tree for TMBIM4 (if available)

Paralogs for TMBIM4 Gene

Paralogs for TMBIM4 Gene

genes like me logo Genes that share paralogs with TMBIM4: view

Variants for TMBIM4 Gene

Sequence variations from dbSNP and Humsavar for TMBIM4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs8793 - 66,152,320(-) GTTGA(C/T)TTTAA missense, reference
rs737614 -- 66,169,426(+) AACGC(A/G)AAACC intron-variant
rs1168742 -- 66,169,034(-) AGATA(G/T)TTCTG intron-variant
rs1168743 -- 66,168,943(-) TTTTT(A/T)AAAAA intron-variant
rs1168744 -- 66,165,656(-) taaac(A/G)ataag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMBIM4 Gene

Variant ID Type Subtype PubMed ID
nsv899214 CNV Loss 21882294
nsv526076 CNV Loss 19592680
nsv899215 CNV Loss 21882294

Relevant External Links for TMBIM4 Gene

HapMap Linkage Disequilibrium report
TMBIM4

Disorders for TMBIM4 Gene

genes like me logo Genes that share disorders with TMBIM4: view

No data available for UniProtKB/Swiss-Prot for TMBIM4 Gene

Publications for TMBIM4 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4
  2. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4

Products for TMBIM4 Gene

  • antibodies-online peptides for TMBIM4
  • antibodies-online antibodies for TMBIM4
  • antibodies-online kits for TMBIM4

Sources for TMBIM4 Gene

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