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TMBIM4 Gene

protein-coding   GIFtS: 48
GCID: GC12M066518

Transmembrane BAX Inhibitor Motif Containing 4

  See TMBIM4-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane BAX Inhibitor Motif Containing 41 2     Golgi Anti-Apoptotic Protein2 3
Transmembrane BAX Inhibitor Motif-Containing Protein 42 3     S1R2
GAAP2 3     ZPRO2
LFG42 3     Protein Lifeguard 42
Z-protein2 3     Protein S1R3

External Ids:    HGNC: 242571   Entrez Gene: 516432   Ensembl: ENSG000001559577   UniProtKB: Q9HC243   

Export aliases for TMBIM4 gene to outside databases

Previous GC identifers: GC12M064818 GC12M066531 GC12M063581


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMBIM4 Gene:
TMBIM4 (transmembrane BAX inhibitor motif containing 4) is a protein-coding gene. Diseases associated with TMBIM4 include venezuelan hemorrhagic fever, and argentine hemorrhagic fever. An important paralog of this gene is TMBIM1.

UniProtKB/Swiss-Prot: LFG4_HUMAN, Q9HC24
Function: Anti-apoptotic protein which can inhibit apoptosis induced by intrinsic and extrinsic apoptotic stimuli.
Can modulate both capacitative Ca2+ entry and inositol 1,4,5-trisphosphate (IP3)-mediated Ca2+ release

Gene Wiki entry for TMBIM4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMBIM4 gene promoter:
         AP-1   NCX/Ncx   ATF-2   Nkx2-5   NF-AT   PPAR-gamma1   PPAR-gamma2   c-Jun   NF-kappaB1   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMBIM4 promoter sequence
   Search Chromatin IP Primers for TMBIM4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMBIM4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q14.3   Ensembl cytogenetic band:  12q14.3   HGNC cytogenetic band: 12q14.3

TMBIM4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMBIM4 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M066518:  view genomic region     (about GC identifiers)

Start:
66,517,709 bp from pter      End:
66,563,852 bp from pter
Size:
46,144 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LFG4_HUMAN, Q9HC24 (See protein sequence)
Recommended Name: Protein lifeguard 4  
Size: 238 amino acids; 26971 Da
Subunit: Interacts with ITPR3
Sequence caution: Sequence=AAD34114.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q542Z6 Q9UHY5 Q9Y3C2

Explore the universe of human proteins at neXtProt for TMBIM4: NX_Q9HC24

Explore proteomics data for TMBIM4 at MOPED


See TMBIM4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (4 alternative transcripts): 
NP_001269535.1  NP_001269538.1  NP_001269539.1  NP_057140.2  

ENSEMBL proteins: 
 ENSP00000350965   ENSP00000444639   ENSP00000286424   ENSP00000381114   ENSP00000441291  
 ENSP00000440964   ENSP00000438957   ENSP00000439310   ENSP00000451688  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR006214 Bax_inhibitor_1-related

Graphical View of Domain Structure for InterPro Entry Q9HC24

ProtoNet protein and cluster: Q9HC24

UniProtKB/Swiss-Prot: LFG4_HUMAN, Q9HC24
Similarity: Belongs to the BI1 family. LFG subfamily


Find genes that share domains with TMBIM4           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: LFG4_HUMAN, Q9HC24
Function: Anti-apoptotic protein which can inhibit apoptosis induced by intrinsic and extrinsic apoptotic stimuli.
Can modulate both capacitative Ca2+ entry and inositol 1,4,5-trisphosphate (IP3)-mediated Ca2+ release

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding IPI19553469
     
Find genes that share ontologies with TMBIM4           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for TMBIM4:
 Increased gamma-H2AX phosphory 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMBIM4
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   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMBIM4
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMBIM4

miRNA
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6 qRT-PCR Assays for microRNAs that regulate TMBIM4:
hsa-miR-200c hsa-miR-429 hsa-miR-3143 hsa-miR-200b hsa-miR-556-3p hsa-miR-551b*
SwitchGear 3'UTR luciferase reporter plasmidTMBIM4 3' UTR sequence
Inhib. RNA
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OriGene RNAi products in human, mouse, rat for TMBIM4
Predesigned siRNA for gene silencing in human, mouse, rat TMBIM4

Gene Editing
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Clone
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OriGene ORF clones in mouse, rat for TMBIM4
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GenScript: all cDNA clones in your preferred vector: TMBIM4 (NM_016056)
Sino Biological Human cDNA Clone for TMBIM4
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMBIM4

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMBIM4


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
LFG4_HUMAN, Q9HC24: Golgi apparatus membrane; Multi-pass membrane protein
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
golgi apparatus5
plasma membrane3
cytosol1
endoplasmic reticulum1
nucleus1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000139Golgi membrane IEA--
GO:0005795Golgi stack IDA17319741
GO:0016021integral component of membrane IEA--

Find genes that share ontologies with TMBIM4           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMBIM4
Interactions:

    Search GeneGlobe Interaction Network for TMBIM4

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for TMBIM4 (Q9HC243 ENSP000003509654) via UniProtKB, MINT, STRING, and/or I2D (see all 67)
InteractantInteraction Details
GeneCardExternal ID(s)
CCDC47Q96A333, ENSP000002257264I2D: score=2 STRING: ENSP00000225726
COX4I1P130733, ENSP000002534524I2D: score=2 STRING: ENSP00000253452
DDOSTP396563, ENSP000003641884I2D: score=2 STRING: ENSP00000364188
PPIBP232843, ENSP000003000264I2D: score=2 STRING: ENSP00000300026
PRPSAP1Q145583, ENSP000004146244I2D: score=2 STRING: ENSP00000414624
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Gene Ontology (GO): 3 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006915apoptotic process IEA--
GO:0043066negative regulation of apoptotic process IMP17319741
GO:0050848regulation of calcium-mediated signaling IDA19553469

Find genes that share ontologies with TMBIM4           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for TMBIM4 (LFG4)

3 Novoseek inferred chemical compound relationships for TMBIM4 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
phospholipid 37.1 3 1872862 (2)
serine 16.2 1 2403355 (1)
calcium 0 1 1872862 (1)



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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for TMBIM4 gene (4 alternative transcripts): 
NM_001282606.1  NM_001282609.1  NM_001282610.1  NM_016056.3  

Unigene Cluster for TMBIM4:

Transmembrane BAX inhibitor motif containing 4
Hs.505934  [show with all ESTs]
Unigene Representative Sequence: AL117550
12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000358230(uc001stc.3 uc001std.3 uc009zqr.3 uc001stf.3 uc009zqs.3)
ENST00000544599 ENST00000538217 ENST00000286424 ENST00000398033 ENST00000542724
ENST00000545407 ENST00000545504 ENST00000534930 ENST00000542072 ENST00000535812
ENST00000556010
miRNA
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6 qRT-PCR Assays for microRNAs that regulate TMBIM4:
hsa-miR-200c hsa-miR-429 hsa-miR-3143 hsa-miR-200b hsa-miR-556-3p hsa-miR-551b*
SwitchGear 3'UTR luciferase reporter plasmidTMBIM4 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for TMBIM4
Predesigned siRNA for gene silencing in human, mouse, rat TMBIM4
Clone
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OriGene ORF clones in mouse, rat for TMBIM4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: TMBIM4 (NM_016056)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMBIM4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMBIM4
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for TMBIM4
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMBIM4
  QuantiTect SYBR Green Assays in human, mouse, rat TMBIM4
  QuantiFast Probe-based Assays in human, mouse, rat TMBIM4

Additional mRNA sequence: 

AF113127.1 AF151877.1 AF161526.1 AF182041.1 AF182414.1 AK075069.1 AK094572.1 AK225158.1 
AL117550.1 BC004401.1 BC020613.1 BC052273.1 BC070366.1 BC094852.1 

22 DOTS entries:

DT.100817619  DT.215990  DT.100037203  DT.95135185  DT.104898  DT.100817616  DT.121123237  DT.100817617 
DT.100037204  DT.92327101  DT.100837616  DT.91959619  DT.97800391  DT.121123223  DT.121123234  DT.121123236 
DT.121123254  DT.91761713  DT.95155632  DT.100817612  DT.75196398  DT.99942723 

Selected AceView cDNA sequences (see all 279):

AA912193 BM564028 BM918824 BU689481 CB988270 BM955680 AI018289 AI472103 
BF434508 BM915191 AW614415 AA887381 BQ271316 AA886637 BQ640642 CR597581 
CR597621 T50287 CD244606 CB266504 BX464235 CB998661 BU538307 AA634291 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TMBIM4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AGAGTCCTGC
TMBIM4 Expression
About this image


TMBIM4 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 
 Inner Cell Mass (Early Embryonic Tissues)
         253G4
TMBIM4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TMBIM4 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.505934
    Custom PCR Arrays for TMBIM4
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMBIM4

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for TMBIM4 gene from Selected species (see all 22)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tmbim41 , 5 transmembrane BAX inhibitor motif containing 41, 5 82.07(n)1
84.03(a)1
  10 (67.94 cM)5
682121  NM_026617.31  NP_080893.11 
 1202015905 
chicken
(Gallus gallus)
Aves TMBIM41 transmembrane BAX inhibitor motif containing 4 75.46(n)
77.45(a)
  771874  XM_001235092.2  XP_001235093.1 
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
77(a)
1 → many
GL343256.1(309287-317160)
African clawed frog
(Xenopus laevis)
Amphibia Xl.63022 Xenopus laevis transcribed sequence with weak similarity more 75.53(n)    48023697 
zebrafish
(Danio rerio)
Actinopterygii zgc663432 Danio rerio cDNA clone MGC64112 IMAGE6795228, complete more 70.25(n)    BC057432.1 
fruit fly
(Drosophila melanogaster)
Insecta CG303796
--
23(a)
many ↔ many
2R(3827461-3829375)
worm
(Caenorhabditis elegans)
Secernentea tmbi-41 tmbi-4 46.96(n)
35.11(a)
  181150  NM_077142.5  NP_509543.2 
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BXI16
Protein involved in apoptosis; variously described...
27(a)
1 → many
XIV(58898-59791) YNL305C
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G154701 AT4G15470 50.24(n)
41.15(a)
  827218  NM_117636.2  NP_567466.1 
rice
(Oryza sativa)
Liliopsida Os05g04023001 Os05g0402300 46.79(n)
36.06(a)
  4338736  NM_001062028.1  NP_001055493.1 


ENSEMBL Gene Tree for TMBIM4 (if available)
TreeFam Gene Tree for TMBIM4 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for TMBIM4 gene
TMBIM12  GRINA2  ENSG000002281442  FAIM22  
4 SIMAP similar genes for TMBIM4 using alignment to 10 protein entries:     LFG4_HUMAN (see all proteins):
MDS013    GRINA    TMBIM1    FAIM2

Find genes that share paralogs with TMBIM4           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TMBIM4 (see all 653)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 12 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1395754281,2
C--66367650(+) CTTAAC/TAGCTG 1 -- ds50010--------
rs1894191401,2
--66367722(+) TCCTAA/GTCCCA 1 -- ds50010--------
rs721677561,2
C--66367863(+) CAAGT-/ACAGAGG 1 -- ds50011Minor allele frequency- AC:0.50CSA 2
rs352436931,2
C--66367864(+) AAGTACA/-GAGGG 1 -- ds50011Minor allele frequency- -:0.50NA 2
rs1499979211,2
--66367995(+) AAACAA/CATTTC 1 -- ds50010--------
rs1113168251,2
C--66368082(+) TTTCAC/TTGGTT 1 -- ds50011Minor allele frequency- T:0.50WA 2
rs1816986371,2
--66368097(+) GTACAC/TTGACC 1 -- ds50010--------
rs1452638441,2
--66368136(+) AAACCA/GTAAGA 1 -- ds50010--------
rs1861890441,2
--66368221(+) TAACCA/GCATTA 1 -- ut310--------
rs11687541,2
C,F,A,H--66368227(+) CATTAG/CCATTC 1 -- ut3119Minor allele frequency- C:0.14MN NS EA NA WA CSA 979

HapMap Linkage Disequilibrium report for TMBIM4 (66517709 - 66563852 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for TMBIM4:    About this table    
Variant IDTypeSubtypePubMed ID
nsv899215CNV Loss21882294
nsv526076CNV Loss19592680
nsv899214CNV Loss21882294

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing TMBIM4
DNA2.0 Custom Variant and Variant Library Synthesis for TMBIM4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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5 diseases for TMBIM4:    
About MalaCards
venezuelan hemorrhagic fever    argentine hemorrhagic fever    lassa fever    lymphocytic choriomeningitis
alpha 1-antitrypsin deficiency

4 diseases from the University of Copenhagen DISEASES database for TMBIM4:
Venezuelan hemorrhagic fever     Lassa fever     Alpha 1-antitrypsin deficiency     Argentine hemorrhagic fever

Find genes that share disorders with TMBIM4           About GenesLikeMe


Export disorders for TMBIM4 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TMBIM4 gene, integrated from 10 sources (see all 32):
(articles sorted by number of sources associating them with TMBIM4)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.-H.... Lin W.-C. (Genome Res. 2000)
  2. Six-transmembrane topology for Golgi anti-apoptotic protein (GAAP) and Bax inhibitor 1 (BI-1) provides model for the transmembrane Bax inhibitor-containing motif (TMBIM) family. (PubMed id 22418439)1, 2 Carrara G.... Smith G.L. (J. Biol. Chem. 2012)
  3. Human Golgi antiapoptotic protein modulates intracellular calcium fluxes. (PubMed id 19553469)1, 2 de Mattia F.... van Kuppeveld F.J. (Mol. Biol. Cell 2009)
  4. A new inhibitor of apoptosis from vaccinia virus and eukaryotes. (PubMed id 17319741)1, 2 Gubser C....Smith G.L. (PLoS Pathog. 2007)
  5. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  7. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000)
  8. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 3 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
  9. hGAAP promotes cell adhesion and migration via the stimulation of store-operated Ca2+ entry and calpain 2. (PubMed id 23940116)1 Saraiva N....Smith G.L. (J. Cell Biol. 2013)
  10. Host cell Golgi anti-apoptotic protein (GAAP) and growth of Chlamydia pneumoniae. (PubMed id 23000903)1 Markkula E....Puolakkainen M. (Microb. Pathog. 2013)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 51643 HGNC: 24257 AceView: CGI-119 Ensembl:ENSG00000155957 euGenes: HUgn51643
ECgene: TMBIM4 H-InvDB: TMBIM4

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TMBIM4 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TMBIM4 gene:
Search GeneIP for patents involving TMBIM4

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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