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Aliases for TMBIM4 Gene

Aliases for TMBIM4 Gene

  • Transmembrane BAX Inhibitor Motif Containing 4 2 3 5
  • Transmembrane BAX Inhibitor Motif-Containing Protein 4 3 4
  • Golgi Anti-Apoptotic Protein 3 4
  • Z-Protein 3 4
  • GAAP 3 4
  • LFG4 3 4
  • Protein Lifeguard 4 3
  • Protein S1R 4
  • CGI-119 3
  • ZPRO 3
  • S1R 3

External Ids for TMBIM4 Gene

Previous GeneCards Identifiers for TMBIM4 Gene

  • GC12M064818
  • GC12M066531
  • GC12M063581
  • GC12M066518

Summaries for TMBIM4 Gene

GeneCards Summary for TMBIM4 Gene

TMBIM4 (Transmembrane BAX Inhibitor Motif Containing 4) is a Protein Coding gene. Diseases associated with TMBIM4 include Venezuelan Hemorrhagic Fever. An important paralog of this gene is ENSG00000228144.

UniProtKB/Swiss-Prot for TMBIM4 Gene

  • Anti-apoptotic protein which can inhibit apoptosis induced by intrinsic and extrinsic apoptotic stimuli. Can modulate both capacitative Ca2+ entry and inositol 1,4,5-trisphosphate (IP3)-mediated Ca2+ release.

Gene Wiki entry for TMBIM4 Gene

Additional gene information for TMBIM4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMBIM4 Gene

Genomics for TMBIM4 Gene

GeneHancer (GH) Regulatory Elements for TMBIM4 Gene

Promoters and enhancers for TMBIM4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I066168 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.5 538 2.7 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF263 SP3 ENSG00000228144 TMBIM4 LEMD3 LLPH-AS1 LLPH
GH12I066144 Enhancer 1.2 Ensembl ENCODE dbSUPER 30.8 +24.8 24836 1.3 ELF3 FOXA2 NFIB RAD21 YY1 THAP11 ZNF654 RXRA CEBPB ELF1 TMBIM4 LLPH ENSG00000228144
GH12I065821 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.1 +343.7 343680 10.3 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF213 RPSAP52 HMGA2 GC12M065825 LEMD3 LOC100129940 TMBIM4 ENSG00000250280 ENSG00000256083 ENSG00000277945
GH12I066234 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 14.1 -65.3 -65285 1.7 ATF1 ARNT ZNF76 ZBTB40 RFX5 ZNF335 GLIS2 ATF7 SMARCA5 YY2 RBMS1P1 IRAK3 TMBIM4 ENSG00000228144 HELB ENSG00000256072 LLPH LLPH-AS1 MIR6502
GH12I066129 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 7.1 +38.6 38644 3.5 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 YY1 POLR2B E2F8 ZNF207 ZNF143 LLPH-AS1 LLPH HELB TMBIM4 ENSG00000228144
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMBIM4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMBIM4 gene promoter:

Genomic Locations for TMBIM4 Gene

Genomic Locations for TMBIM4 Gene
34,227 bases
Minus strand

Genomic View for TMBIM4 Gene

Genes around TMBIM4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMBIM4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMBIM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMBIM4 Gene

Proteins for TMBIM4 Gene

  • Protein details for TMBIM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein lifeguard 4
    Protein Accession:
    Secondary Accessions:
    • Q542Z6
    • Q9UHY5
    • Q9Y3C2

    Protein attributes for TMBIM4 Gene

    238 amino acids
    Molecular mass:
    26971 Da
    Quaternary structure:
    • Interacts with ITPR3.
    • Sequence=AAD34114.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for TMBIM4 Gene

Post-translational modifications for TMBIM4 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TMBIM4 Gene

Domains & Families for TMBIM4 Gene

Gene Families for TMBIM4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for TMBIM4 Gene


Suggested Antigen Peptide Sequences for TMBIM4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the BI1 family. LFG subfamily.
  • Belongs to the BI1 family. LFG subfamily.
genes like me logo Genes that share domains with TMBIM4: view

Function for TMBIM4 Gene

Molecular function for TMBIM4 Gene

UniProtKB/Swiss-Prot Function:
Anti-apoptotic protein which can inhibit apoptosis induced by intrinsic and extrinsic apoptotic stimuli. Can modulate both capacitative Ca2+ entry and inositol 1,4,5-trisphosphate (IP3)-mediated Ca2+ release.

Phenotypes From GWAS Catalog for TMBIM4 Gene

Gene Ontology (GO) - Molecular Function for TMBIM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19553469
genes like me logo Genes that share ontologies with TMBIM4: view
genes like me logo Genes that share phenotypes with TMBIM4: view

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMBIM4 Gene

Localization for TMBIM4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMBIM4 Gene

Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMBIM4 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 4
endoplasmic reticulum 2
cytosol 2
mitochondrion 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMBIM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus IDA --
GO:0005795 Golgi stack IDA 17319741
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMBIM4: view

Pathways & Interactions for TMBIM4 Gene

SuperPathways for TMBIM4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMBIM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0043066 negative regulation of apoptotic process IMP 17319741
GO:0050848 regulation of calcium-mediated signaling IDA 19553469
genes like me logo Genes that share ontologies with TMBIM4: view

No data available for Pathways by source and SIGNOR curated interactions for TMBIM4 Gene

Drugs & Compounds for TMBIM4 Gene

(2) Drugs for TMBIM4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for TMBIM4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TMBIM4: view

Transcripts for TMBIM4 Gene

Unigene Clusters for TMBIM4 Gene

Transmembrane BAX inhibitor motif containing 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMBIM4 Gene

No ASD Table

Relevant External Links for TMBIM4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMBIM4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMBIM4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMBIM4 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMBIM4 Gene

Protein tissue co-expression partners for TMBIM4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMBIM4 Gene:


SOURCE GeneReport for Unigene cluster for TMBIM4 Gene:


Evidence on tissue expression from TISSUES for TMBIM4 Gene

  • Adrenal gland(4.4)
  • Nervous system(3.5)
  • Liver(2.9)
  • Kidney(2.4)
  • Intestine(2.3)
  • Lung(2.2)
  • Muscle(2.1)
  • Skin(2.1)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with TMBIM4: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMBIM4 Gene

Orthologs for TMBIM4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TMBIM4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMBIM4 33
  • 99.44 (n)
-- 34
  • 82 (a)
(Canis familiaris)
Mammalia TMBIM4 33
  • 89.22 (n)
-- 34
  • 89 (a)
(Bos Taurus)
Mammalia TMBIM4 33
  • 88.66 (n)
CGI-119 34
  • 86 (a)
(Rattus norvegicus)
Mammalia Tmbim4 33
  • 82.77 (n)
(Mus musculus)
Mammalia Tmbim4 33 16 34
  • 82.07 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 82 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 75 (a)
(Gallus gallus)
Aves -- 34
  • 77 (a)
  • 75.46 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmbim4 33
  • 68.23 (n)
Str.11131 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.6302 33
(Danio rerio)
Actinopterygii tmbim4 33 34
  • 64.23 (n)
zgc66343 33
fruit fly
(Drosophila melanogaster)
Insecta CG30379 34
  • 23 (a)
(Caenorhabditis elegans)
Secernentea tmbi-4 33 34
  • 46.96 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BXI1 34
  • 27 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G15470 33
  • 50.24 (n)
(Oryza sativa)
Liliopsida Os05g0402300 33
  • 46.79 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes bxi1 33
  • 50.86 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8799 34
  • 48 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02463 33
  • 47.39 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4667 33
Species where no ortholog for TMBIM4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMBIM4 Gene

Gene Tree for TMBIM4 (if available)
Gene Tree for TMBIM4 (if available)

Paralogs for TMBIM4 Gene

Paralogs for TMBIM4 Gene

genes like me logo Genes that share paralogs with TMBIM4: view

Variants for TMBIM4 Gene

Sequence variations from dbSNP and Humsavar for TMBIM4 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000082605 -- 66,147,570(-) A/G intron_variant
rs1000147157 -- 66,149,259(-) A/G intron_variant
rs1000286727 -- 66,167,609(-) A/C intron_variant
rs1000430720 -- 66,138,604(-) T/C intron_variant
rs1000431831 -- 66,147,164(-) AGAGA/AGA intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMBIM4 Gene

Variant ID Type Subtype PubMed ID
esv3629796 CNV loss 21293372
nsv526076 CNV loss 19592680
nsv976636 CNV duplication 23825009

Variation tolerance for TMBIM4 Gene

Residual Variation Intolerance Score: 53.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.54; 86.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMBIM4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMBIM4 Gene

Disorders for TMBIM4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMBIM4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
venezuelan hemorrhagic fever
  • guanarito hemorrhagic fever
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TMBIM4

genes like me logo Genes that share disorders with TMBIM4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMBIM4 Gene

Publications for TMBIM4 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 2 3 4 58
  2. Six-transmembrane topology for Golgi anti-apoptotic protein (GAAP) and Bax inhibitor 1 (BI-1) provides model for the transmembrane Bax inhibitor-containing motif (TMBIM) family. (PMID: 22418439) Carrara G … Smith GL (The Journal of biological chemistry 2012) 3 4 58
  3. Human Golgi antiapoptotic protein modulates intracellular calcium fluxes. (PMID: 19553469) de Mattia F … van Kuppeveld FJ (Molecular biology of the cell 2009) 3 4 58
  4. A new inhibitor of apoptosis from vaccinia virus and eukaryotes. (PMID: 17319741) Gubser C … Smith GL (PLoS pathogens 2007) 3 4 58
  5. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 58

Products for TMBIM4 Gene

Sources for TMBIM4 Gene

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