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Aliases for TMBIM1 Gene

Aliases for TMBIM1 Gene

  • Transmembrane BAX Inhibitor Motif Containing 1 2 3
  • RECS1 3 4 6
  • Transmembrane BAX Inhibitor Motif-Containing Protein 1 3 4
  • LFG3 3 4
  • Protein RECS1 Homolog 4
  • Protein Lifeguard 3 3
  • MSTP100 3
  • MST100 3
  • PP1201 3

External Ids for TMBIM1 Gene

Previous GeneCards Identifiers for TMBIM1 Gene

  • GC02M218965
  • GC02M218847
  • GC02M219139
  • GC02M210992

Summaries for TMBIM1 Gene

GeneCards Summary for TMBIM1 Gene

TMBIM1 (Transmembrane BAX Inhibitor Motif Containing 1) is a Protein Coding gene. An important paralog of this gene is FAIM2.

UniProtKB/Swiss-Prot for TMBIM1 Gene

  • Negatively regulates aortic matrix metalloproteinase-9 (MMP9) production and may play a protective role in vascular remodeling

Gene Wiki entry for TMBIM1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMBIM1 Gene

Genomics for TMBIM1 Gene

Regulatory Elements for TMBIM1 Gene

Genomic Location for TMBIM1 Gene

Start:
218,274,192 bp from pter
End:
218,292,586 bp from pter
Size:
18,395 bases
Orientation:
Minus strand

Genomic View for TMBIM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMBIM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMBIM1 Gene

Proteins for TMBIM1 Gene

  • Protein details for TMBIM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969X1-LFG3_HUMAN
    Recommended name:
    Protein lifeguard 3
    Protein Accession:
    Q969X1
    Secondary Accessions:
    • B3KQY6
    • Q8N1R3
    • Q8TAM3
    • Q96K13

    Protein attributes for TMBIM1 Gene

    Size:
    311 amino acids
    Molecular mass:
    34607 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH26693.1; Type=Frameshift; Positions=6; Evidence={ECO:0000305}; Sequence=BAB55346.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC11636.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for TMBIM1 Gene

Proteomics data for TMBIM1 Gene at MOPED

Post-translational modifications for TMBIM1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMBIM1 Gene

Domains for TMBIM1 Gene

Protein Domains for TMBIM1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q969X1

UniProtKB/Swiss-Prot:

LFG3_HUMAN :
  • Q969X1
Family:
  • Belongs to the BI1 family. LFG subfamily.
genes like me logo Genes that share domains with TMBIM1: view

No data available for Gene Families for TMBIM1 Gene

Function for TMBIM1 Gene

Molecular function for TMBIM1 Gene

UniProtKB/Swiss-Prot Function: Negatively regulates aortic matrix metalloproteinase-9 (MMP9) production and may play a protective role in vascular remodeling

Gene Ontology (GO) - Molecular Function for TMBIM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005123 death receptor binding IDA 21107705
genes like me logo Genes that share ontologies with TMBIM1: view

Phenotypes for TMBIM1 Gene

GenomeRNAi human phenotypes for TMBIM1:
genes like me logo Genes that share phenotypes with TMBIM1: view

Animal Model Products

CRISPR Products

miRNA for TMBIM1 Gene

miRTarBase miRNAs that target TMBIM1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMBIM1 Gene

Localization for TMBIM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMBIM1 Gene

Membrane; Multi-pass membrane protein. Lysosome membrane. Endosome membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMBIM1 Gene COMPARTMENTS Subcellular localization image for TMBIM1 gene
Compartment Confidence
endosome 5
lysosome 5
vacuole 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TMBIM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IDA 16607040
GO:0005794 Golgi apparatus IDA 21107705
GO:0010008 endosome membrane IDA 16607040
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with TMBIM1: view

Pathways for TMBIM1 Gene

SuperPathways for TMBIM1 Gene

No Data Available

Interacting Proteins for TMBIM1 Gene

Gene Ontology (GO) - Biological Process for TMBIM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048553 negative regulation of metalloenzyme activity ISS --
GO:0090005 negative regulation of establishment of protein localization to plasma membrane IMP 21107705
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IMP 21107705
GO:1902045 negative regulation of Fas signaling pathway IMP 21107705
GO:2000504 positive regulation of blood vessel remodeling ISS --
genes like me logo Genes that share ontologies with TMBIM1: view

No data available for Pathways by source for TMBIM1 Gene

Transcripts for TMBIM1 Gene

Unigene Clusters for TMBIM1 Gene

Transmembrane BAX inhibitor motif containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMBIM1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMBIM1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1:
SP2: -
SP3: -
SP4: -
SP5: - -

Relevant External Links for TMBIM1 Gene

GeneLoc Exon Structure for
TMBIM1
ECgene alternative splicing isoforms for
TMBIM1

Expression for TMBIM1 Gene

mRNA expression in normal human tissues for TMBIM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMBIM1 Gene

SOURCE GeneReport for Unigene cluster for TMBIM1 Gene Hs.591605

genes like me logo Genes that share expressions with TMBIM1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMBIM1 Gene

Orthologs for TMBIM1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TMBIM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMBIM1 35
  • 99.14 (n)
  • 99.36 (a)
TMBIM1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RECS1 36
  • 86 (a)
OneToOne
TMBIM1 35
  • 87.12 (n)
  • 86.04 (a)
dog
(Canis familiaris)
Mammalia TMBIM1 35
  • 82.86 (n)
  • 83.33 (a)
TMBIM1 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmbim1 35
  • 86.08 (n)
  • 89.32 (a)
Tmbim1 16
Tmbim1 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMBIM1 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmbim1 35
  • 85.76 (n)
  • 88.35 (a)
chicken
(Gallus gallus)
Aves TMBIM1 35
  • 70.59 (n)
  • 71.24 (a)
TMBIM1 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMBIM1 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmbim1 35
  • 65.59 (n)
  • 66.45 (a)
zebrafish
(Danio rerio)
Actinopterygii tmbim1 35
  • 61.97 (n)
  • 58.39 (a)
tmbim1 36
  • 51 (a)
OneToMany
TMBIM1 (2 of 2) 36
  • 46 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG9722 36
  • 33 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea tag-120 36
  • 36 (a)
ManyToMany
xbx-6 36
  • 33 (a)
ManyToMany
Y42H9AR.2 36
  • 34 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BXI1 36
  • 23 (a)
OneToMany
BXI1 38
Species with no ortholog for TMBIM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMBIM1 Gene

ENSEMBL:
Gene Tree for TMBIM1 (if available)
TreeFam:
Gene Tree for TMBIM1 (if available)

Paralogs for TMBIM1 Gene

Paralogs for TMBIM1 Gene

genes like me logo Genes that share paralogs with TMBIM1: view

Variants for TMBIM1 Gene

Sequence variations from dbSNP and Humsavar for TMBIM1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
VAR_017382 -

Structural Variations from Database of Genomic Variants (DGV) for TMBIM1 Gene

Variant ID Type Subtype PubMed ID
nsv875854 CNV Gain 21882294
nsv519829 CNV Loss 19592680

Relevant External Links for TMBIM1 Gene

HapMap Linkage Disequilibrium report
TMBIM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMBIM1 Gene

Disorders for TMBIM1 Gene

No disorders were found for TMBIM1 Gene.

No data available for UniProtKB/Swiss-Prot for TMBIM1 Gene

Publications for TMBIM1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4
  4. RECS1 deficiency in mice induces susceptibility to cystic medial degeneration. (PMID: 16607040) Zhao H. … Nojima H. (Genes Genet. Syst. 2006) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3

Products for TMBIM1 Gene

  • antibodies-online peptides for TMBIM1
  • antibodies-online antibodies for TMBIM1
  • antibodies-online kits for TMBIM1

Sources for TMBIM1 Gene

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