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TMA7 Gene

protein-coding   GIFtS: 33
GCID: GC03P048481

Translation Machinery Associated 7 Homolog (S. Cerevisiae)

(Previous name: coiled-coil domain containing 72)
(Previous symbol: CCDC72)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Translation Machinery Associated 7 Homolog (S. Cerevisiae)1 2
CCDC721 2 3
Coiled-Coil Domain Containing 721 2
Coiled-Coil Domain-Containing Protein 722 3
Translation Machinery-Associated Protein 72
Translational Machinery Associated 7 Homolog2

External Ids:    HGNC: 269321   Entrez Gene: 513722   Ensembl: ENSG000002321127   UniProtKB: Q9Y2S63   
ORGUL members:         

Export aliases for TMA7 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMA7 Gene:
TMA7 (translation machinery associated 7 homolog (S. cerevisiae)) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_022517.19  
Regulatory elements:
   Search for regulatory transcription factor binding sites for TMA7
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMA7 promoter sequence
   Search Chromatin IP Primers for TMA7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMA7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.31

TMA7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMA7 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P048481:  view genomic region     (about GC identifiers)

Start:
48,481,667 bp from pter      End:
48,485,616 bp from pter
Size:
3,950 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
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UniProtKB/Swiss-Prot: TMA7_HUMAN, Q9Y2S6 (See protein sequence)
Recommended Name: Translation machinery-associated protein 7  
Size: 64 amino acids; 7066 Da
Secondary accessions: Q9P052

Explore the universe of human proteins at neXtProt for TMA7: NX_Q9Y2S6

Explore proteomics data for TMA7 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TMA7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057017.1  
    ENSEMBL proteins: 
     ENSP00000397843  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR015157 TMA7

    Graphical View of Domain Structure for InterPro Entry Q9Y2S6

    ProtoNet protein and cluster: Q9Y2S6

    UniProtKB/Swiss-Prot: TMA7_HUMAN, Q9Y2S6
    Similarity: Belongs to the TMA7 family


    Find genes that share domains with TMA7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 GenomeRNAi human phenotype for TMA7:
     Increased HPV18 LCR reporter a 

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMA7
    Interactions:

        Search GeneGlobe Interaction Network for TMA7

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMA7



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TMA7 gene: 
    NM_015933.4  

    Unigene Cluster for TMA7:

    Translation machinery associated 7 homolog (S. cerevisiae)
    Hs.356440  [show with all ESTs]
    Unigene Representative Sequence: AK126594
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000479126 ENST00000438607(uc003cte.1) ENST00000477624
    miRNA
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    Additional mRNA sequence: 

    AF077202.1 AF161448.1 AK126594.1 AY508979.1 AY794023.1 BC001102.2 BC066333.1 BC080531.1 

    Selected DOTS entries (see all 31):

    DT.100045541  DT.91650308  DT.91974849  DT.100043654  DT.91785034  DT.100045538  DT.92003573  DT.95255324 
    DT.95334529  DT.446693  DT.100691720  DT.120906331  DT.101985407  DT.95334556  DT.91785042  DT.91993133 
    DT.95334552  DT.95328318  DT.120906198  DT.91747562  DT.100045537  DT.100691715  DT.100691737  DT.101986259 

    Selected AceView cDNA sequences (see all 519):

    AW895930 F28809 BG319566 AW674436 CD251734 AI709253 AI090805 AI143585 
    AI342191 AI745179 BP429087 AA361058 AI339191 BE774614 AW615491 AW028529 
    AI420748 F30411 AI187137 AW161829 AI422705 AV653388 AI333234 BE774571 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMA7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TMA7 Expression
    About this image

    TMA7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMA7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.356440
        Custom PCR Arrays for TMA7
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TMA7 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tma71 , 5 coiled-coil domain containing 725
    translational machinery associated 7 homolog (S. cerevisiae)1
    94.27(n)1
    100(a)1
      9 (59.63 cM)5
    661671  NM_183250.21  NP_899073.11 
     1090779885 
    lizard
    (Anolis carolinensis)
    Reptilia TMA76
    translation machinery associated 7 homolog (S. cer...
    91(a)
    1 ↔ 1
    2(190373468-190379602)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.62962 Transcribed sequence with moderate similarity to protein more 74.54(n)    137697214 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.133342 Transcribed sequence with moderate similarity to protein more 79.01(n)    AL729673.1 


    ENSEMBL Gene Tree for TMA7 (if available)
    TreeFam Gene Tree for TMA7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMA7 (see all 52)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1912288501,2
    --48483555(+) GCCTCA/GCTTAA 1 -- int10--------
    rs1815770841,2
    --48483604(+) GAGTTC/GAGGCT 1 -- int10--------
    rs1396752501,2
    --48483627(+) GATTGC/TGCCAC 1 -- int10--------
    rs1498581661,2
    --48483637(+) CTGTAC/TTCCAG 1 -- int10--------
    rs23624411,2
    C,A--48483682(+) aaaaaG/Aaaaaa 1 -- int11Minor allele frequency- A:0.50NA 2
    rs1998298951,2
    --48483682(+) AAAAA-/GAAAAA 1 -- int10--------
    rs1857011291,2
    C--48483728(+) TATAGA/GGGAAA 1 -- int10--------
    rs1899725281,2
    --48483785(+) TCATCG/TGATTT 1 -- int10--------
    rs1821348431,2
    --48483892(+) GTCTCA/TCTCTG 1 -- int10--------
    rs1879730411,2
    --48483949(+) TCCGCC/TTCCCA 1 -- int10--------

    HapMap Linkage Disequilibrium report for TMA7 (48481667 - 48485616 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TMA7: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TMA7
    DNA2.0 Custom Variant and Variant Library Synthesis for TMA7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMA7 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with TMA7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    2. Apoptosis of the dermal papilla cells of hair follicle associated with the expression of gene HSPCO16 in vitro. (PubMed id 15740594)1, 3, 9 Yang W.B....Ni B. (Exp. Dermatol. 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 protein. (PubMed id 23940030)1 Teixeira F.R....Gomes M.D. (J. Biol. Chem. 2013)
    5. Effect of HSPC016 gene expression on the aggregative growth of dermal papillae cells. (PubMed id 22571579)1 Song Z....Hao F. (Australas. J. Dermatol. 2012)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    9. Identification of differentially expressed genes HSPC016 in dermal papilla cells with aggregative behavior. (PubMed id 16096800)1 Zhiqiang S....Chunlan L. (Arch. Dermatol. Res. 2005)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51372 HGNC: 26932 AceView: HSPC016 Ensembl:ENSG00000232112 euGenes: HUgn51372
    ECgene: TMA7 H-InvDB: TMA7

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TMA7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMA7 gene:
    Search GeneIP for patents involving TMA7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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