TMA16 Gene
protein-coding GIFtS: 38
GCID: GC04P164416
|
|
translation machinery associated 16 homolog (S. cerevisiae)(Previous name: chromosome 4 open reading frame 43 )
(Previous symbol: C4orf43)
| |
Aliases
for TMA16 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Translation Machinery Associated 16 Homolog (S. Cerevisiae)1 2 | | C4orf431 2 3 | | FLJ111841 | | Chromosome 4 Open Reading Frame 431 | | Translation Machinery-Associated Protein 162 | | UPF0534 Protein C4orf432 |
Export aliases for TMA16 gene to outside databases |
Summaries
for TMA16 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TMA16 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for TMA16
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMA16
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMA16 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q32.2 Ensembl cytogenetic band: 4q32.2 HGNC cytogenetic band: 4q32.3TMA16 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P164416: view genomic region
(about GC identifiers)
Start:
|
164,415,594 bp from pter |
End:
|
164,441,691 bp from pter |
Size:
|
26,098 bases |
Orientation:
|
plus strand |
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Proteins
for TMA16 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TMA16_HUMAN, Q96EY4 (See
protein sequence)Recommended Name: Translation machinery-associated protein 16 Size: 203 amino acids; 23864 Da
Secondary accessions: Q0P6E4 Q0P6J1 Q9NUR7Explore the universe of human proteins at neXtProt for TMA16: NX_Q96EY4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96EY4
TMA16 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060822.2
ENSEMBL proteins: ENSP00000425347 ENSP00000351380 ENSP00000426933 ENSP00000423901 ENSP00000423375
Human Recombinant Protein Products for TMA16:
TMA16 Antibody Products:
Assay Products for TMA16: |
Protein
Domains /
Families
for TMA16 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMA16 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96EY4ProtoNet protein and cluster: Q96EY4 UniProtKB/Swiss-Prot: TMA16_HUMAN, Q96EY4Similarity: Belongs to the UPF0534 family |
Function
for TMA16 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Phenotypes:
1 GenomeRNAi human phenotype for TMA16:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMA16 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMA16
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for TMA16 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMA16 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMA16 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMA16 |
|
Pathways & Interactions
for TMA16 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMA16
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
5/9 Interacting proteins for TMA16 (Q96EY43 ENSP000003513804) via UniProtKB, MINT, STRING, and/or I2D (see all 9)About this table
|
Drugs & Compounds
for TMA16 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMA16
Search CenterWatch for drugs/clinical trials and news about TMA16
|
Transcripts
for TMA16 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMA16 gene: NM_018352.2 Unigene Cluster for TMA16: Translation machinery associated 16 homolog (S. cerevisiae) Hs.267446 [show with all ESTs]Unigene Representative Sequence: NM_0183529 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000509657 ENST00000358572(uc003iqq.4) ENST00000513272 ENST00000508652
ENST00000511562 ENST00000513134 ENST00000508268 ENST00000506214 ENST00000503148
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMA16 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMA16
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for TMA16 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMA16 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMA16 |
Additional cDNA sequence: AK002046.1 AK298235.1 BC005204.1 BC011842.2 BC017418.1 6 DOTS entries: DT.450257 DT.91757835 DT.95270724 DT.100789622 DT.91757839 DT.99946993 24/140 AceView cDNA sequences (see all 140): BX370094 CR605828 CR612293 AI367124 BQ433290 AA708672 CR602863 AA976852 BM472398 AI285136 AW072372 BU195558 AA909754 CR608348 BU159489 CR595986 CR620535 BU521127 AI381993 AI122657 BG615901 AA812581 AW591527 AW190341
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for TMA16 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b |
|---|
|
| SP1: | | | | | | | | | | | |
| SP2: | | | - | | | | | | | |
ECgene alternative splicing isoforms for TMA16
|
Expression
for TMA16 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMA16 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCAAAGCAC
About this image
See TMA16 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMA16
SOURCE GeneReport for Unigene cluster: Hs.267446
SABiosciences Custom PCR Arrays for TMA16
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMA16
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat TMA16 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMA16 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMA16 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMA16 |
Orthologs
for TMA16 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TMA16 gene from 6/20 species (see all 20) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Tma161 , 5 |
RIKEN cDNA 1810029B16 gene5
translation machinery associated 16 homolog (S. cerevisiae)1 |
83.5(n)1
77.72(a)1 |
|
8 (33.14 cM)5
662821 NM_025465.21 NP_079741.11
664743305 |
chicken
(Gallus gallus) |
Aves |
TMA161 |
translation machinery associated 16 homolog (S. cerevisiae) |
69.46(n)
72.46(a) |
|
770087 XM_001233404.2 XP_001233405.2 |
lizard
(Anolis carolinensis) |
Reptilia |
C4orf436 |
-- |
72(a) |
1 ↔ 1 |
5(126024168-126047772) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.116912 |
Xenopus laevis transcribed sequence with weak similarity more |
76.36(n) |
|
BX843702.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.176692 |
Transcribed sequence with weak similarity to protein more |
72.64(n) |
|
BQ074502.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG150271 |
CG15027 |
47.46(n)
35.1(a) |
|
32440 NM_132771.1 NP_572999.1 |
ENSEMBL Gene Tree for TMA16 (if available)
TreeFam Gene Tree for TMA16 (if available) |
Paralogs
for TMA16 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TMA16 gene
TMA16 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for TMA16
PGOHUM00000242305 PGOHUM00000244004
|
Genomic Variants
for TMA16 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 4 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMA16 (164415594 - 164441691 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TMA16: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMA16 |
|
Disorders
/ Diseases
for TMA16 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for TMA16 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMA16 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with TMA16) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Expanding the substantial interactome of NEMO using p rotein microarrays. (PubMed id 20098747)1 Fenner B.J....Prehn J.H. (2010)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PubMed id 19953087)1 Persaud A....Rotin D. (2009)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
|
External Searches for TMA16 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMA16 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMA16 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMA16 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMA16 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMA16 gene:
Search GeneIP for patents involving TMA16
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMA16 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TMA16 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMA16 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMA16 | | | OriGene Protein Over-expression Lysate for TMA16 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMA16 | | OriGene 3'-UTR Clone for TMA16 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMA16 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMA16 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMA16 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMA16 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMA16 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMA16 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMA16 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMA16 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for TMA16 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | TMA16 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMA16 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for TMA16 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMA16 |
| |  | |
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