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Aliases for TMA16 Gene

Aliases for TMA16 Gene

  • Translation Machinery Associated 16 Homolog 2 3 5
  • C4orf43 3 4
  • Translation Machinery Associated 16 Homolog (S. Cerevisiae) 2
  • Translation Machinery-Associated Protein 16 3
  • Chromosome 4 Open Reading Frame 43 2
  • UPF0534 Protein C4orf43 3

External Ids for TMA16 Gene

Previous HGNC Symbols for TMA16 Gene

  • C4orf43

Previous GeneCards Identifiers for TMA16 Gene

  • GC04P164416

Summaries for TMA16 Gene

GeneCards Summary for TMA16 Gene

TMA16 (Translation Machinery Associated 16 Homolog) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMA16 Gene

Genomics for TMA16 Gene

Regulatory Elements for TMA16 Gene

Enhancers for TMA16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around TMA16 on UCSC Golden Path with GeneCards custom track

Promoters for TMA16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for TMA16 Gene

163,494,289 bp from pter
163,520,539 bp from pter
26,251 bases
Plus strand

Genomic View for TMA16 Gene

Genes around TMA16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMA16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMA16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMA16 Gene

Proteins for TMA16 Gene

  • Protein details for TMA16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Translation machinery-associated protein 16
    Protein Accession:
    Secondary Accessions:
    • Q0P6E4
    • Q0P6J1
    • Q9NUR7

    Protein attributes for TMA16 Gene

    203 amino acids
    Molecular mass:
    23864 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMA16 Gene

Post-translational modifications for TMA16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMA16 Gene

No data available for DME Specific Peptides for TMA16 Gene

Domains & Families for TMA16 Gene

Protein Domains for TMA16 Gene


Suggested Antigen Peptide Sequences for TMA16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPF0534 family.
  • Belongs to the UPF0534 family.
genes like me logo Genes that share domains with TMA16: view

No data available for Gene Families for TMA16 Gene

Function for TMA16 Gene

Gene Ontology (GO) - Molecular Function for TMA16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TMA16: view
genes like me logo Genes that share phenotypes with TMA16: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMA16 Gene

Localization for TMA16 Gene

Subcellular locations from

Jensen Localization Image for TMA16 Gene COMPARTMENTS Subcellular localization image for TMA16 gene
Compartment Confidence
nucleus 5
cytosol 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TMA16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with TMA16: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TMA16 Gene

Pathways & Interactions for TMA16 Gene

SuperPathways for TMA16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMA16 Gene


No data available for Pathways by source and SIGNOR curated interactions for TMA16 Gene

Drugs & Compounds for TMA16 Gene

No Compound Related Data Available

Transcripts for TMA16 Gene

Unigene Clusters for TMA16 Gene

Translation machinery associated 16 homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMA16 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b
SP2: -

Relevant External Links for TMA16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMA16 Gene

mRNA expression in normal human tissues for TMA16 Gene

Protein differential expression in normal tissues from HIPED for TMA16 Gene

This gene is overexpressed in Pancreas (16.8), Breast (11.7), and Lung (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMA16 Gene

Protein tissue co-expression partners for TMA16 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMA16 Gene:


SOURCE GeneReport for Unigene cluster for TMA16 Gene:

genes like me logo Genes that share expression patterns with TMA16: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMA16 Gene

Orthologs for TMA16 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMA16 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMA16 34
  • 86.7 (n)
  • 82.76 (a)
TMA16 35
  • 83 (a)
(Canis familiaris)
Mammalia TMA16 34
  • 90.15 (n)
  • 88.18 (a)
TMA16 35
  • 88 (a)
(Mus musculus)
Mammalia Tma16 34
  • 83.5 (n)
  • 77.72 (a)
Tma16 16
Tma16 35
  • 71 (a)
(Pan troglodytes)
Mammalia TMA16 34
  • 99.67 (n)
  • 99.51 (a)
TMA16 35
  • 100 (a)
(Rattus norvegicus)
Mammalia Tma16 34
  • 83 (n)
  • 78.22 (a)
(Monodelphis domestica)
Mammalia TMA16 35
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia TMA16 35
  • 61 (a)
(Gallus gallus)
Aves C4H4ORF43 34
  • 69.46 (n)
  • 72.46 (a)
TMA16 35
  • 65 (a)
(Anolis carolinensis)
Reptilia TMA16 35
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10731 34
tma16 34
  • 66.84 (n)
  • 67.89 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.11691 34
(Danio rerio)
Actinopterygii tma16 34
  • 65.26 (n)
  • 65.26 (a)
tma16 35
  • 61 (a)
Dr.17669 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003543 34
  • 48.61 (n)
  • 38.89 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15027 34
  • 47.56 (n)
  • 35.33 (a)
CG15027 35
  • 31 (a)
Species where no ortholog for TMA16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMA16 Gene

Gene Tree for TMA16 (if available)
Gene Tree for TMA16 (if available)

Paralogs for TMA16 Gene Pseudogenes for TMA16 Gene

genes like me logo Genes that share paralogs with TMA16: view

No data available for Paralogs for TMA16 Gene

Variants for TMA16 Gene

Sequence variations from dbSNP and Humsavar for TMA16 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs2304802 - 163,514,113(-) TTTTT(G/T)GGGGA reference, missense
rs1561736 - 163,519,429(+) AACTA(C/T)TATAA downstream-variant-500B, reference, missense
rs34907234 - 163,507,064(-) TTTCC(C/T)GTCCT reference, missense
rs1074604 -- 163,516,093(-) GGAAA(G/T)AGTGG intron-variant
rs1441721 -- 163,518,938(+) ATTAC(A/G/T)TCTAA intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TMA16 Gene

Variant ID Type Subtype PubMed ID
esv2728665 CNV deletion 23290073
esv3564913 CNV deletion 23714750
nsv1015505 CNV gain 25217958
nsv1028437 CNV gain 25217958
nsv1030184 CNV loss 25217958

Variation tolerance for TMA16 Gene

Residual Variation Intolerance Score: 82.3% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMA16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMA16 Gene

Disorders for TMA16 Gene

Relevant External Links for TMA16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMA16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMA16 Gene

Publications for TMA16 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 65
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 65
  4. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3 65
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 65

Products for TMA16 Gene

Sources for TMA16 Gene

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